locus-tag	class	description
HYP10_gp006	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYP10_gp025	COG0563	adenylate kinase activity
HYP10_gp187	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYP10_gp191	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HYP10_gp194	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYP10_gp194	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYP10_gp210	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYP10_gp229	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HYP10_gp264	COG4474	Belongs to the UPF0398 family
HYP10_gp276	COG0187	DNA topoisomerase II activity
HYP10_gp295	COG3118	belongs to the thioredoxin family