locus-tag	class	description
LPB136_RS00030	COG1595	DNA-templated transcription, initiation
LPB136_RS00035	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LPB136_RS00060	COG2884	Cell division ATP-binding protein ftsE
LPB136_RS00090	COG3530	Putative quorum-sensing-regulated virulence factor
LPB136_RS00105	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LPB136_RS00110	COG2885	chlorophyll binding
LPB136_RS00110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LPB136_RS00115	COG2234	aminopeptidase activity
LPB136_RS00120	COG1404	Belongs to the peptidase S8 family
LPB136_RS00140	COG4206	TonB-dependent receptor
LPB136_RS00140	COG1629	transport
LPB136_RS00145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPB136_RS00160	COG0569	domain protein
LPB136_RS00165	COG2003	Belongs to the UPF0758 family
LPB136_RS00185	COG0438	transferase activity, transferring glycosyl groups
LPB136_RS00190	COG1011	Hydrolase
LPB136_RS00200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPB136_RS00210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPB136_RS00225	COG4771	TonB-dependent receptor
LPB136_RS00235	COG1629	transport
LPB136_RS00250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LPB136_RS00255	COG0049	tRNA binding
LPB136_RS00260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LPB136_RS00265	COG0051	transcription antitermination factor activity, RNA binding
LPB136_RS00270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LPB136_RS00275	COG0088	Forms part of the polypeptide exit tunnel
LPB136_RS00280	COG0089	rRNA binding
LPB136_RS00285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LPB136_RS00290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LPB136_RS00295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LPB136_RS00300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LPB136_RS00305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LPB136_RS00310	COG0255	Belongs to the universal ribosomal protein uL29 family
LPB136_RS00315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LPB136_RS00320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LPB136_RS00325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LPB136_RS00330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LPB136_RS00335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LPB136_RS00340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LPB136_RS00345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LPB136_RS00350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LPB136_RS00355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LPB136_RS00360	COG1841	ribosomal large subunit assembly
LPB136_RS00365	COG0200	Binds to the 23S rRNA
LPB136_RS00370	COG0201	protein transport
LPB136_RS00375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LPB136_RS00380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LPB136_RS00385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LPB136_RS00390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LPB136_RS00395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LPB136_RS00400	COG0202	RNA polymerase activity
LPB136_RS00405	COG0203	ribosomal protein L17
LPB136_RS00410	COG0505	Belongs to the CarA family
LPB136_RS00415	COG0148	phosphopyruvate hydratase activity
LPB136_RS00435	COG2339	peptidase activity
LPB136_RS00465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPB136_RS00490	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LPB136_RS00490	COG0662	Cupin 2, conserved barrel domain protein
LPB136_RS00495	COG3091	SprT-like family
LPB136_RS00510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPB136_RS00525	COG0254	rRNA binding
LPB136_RS00530	COG0069	glutamate synthase activity
LPB136_RS00535	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPB136_RS00535	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPB136_RS00545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPB136_RS00550	COG3844	kynureninase activity
LPB136_RS00555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPB136_RS00590	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_RS00595	COG0662	Cupin 2, conserved barrel domain protein
LPB136_RS00620	COG4589	Belongs to the CDS family
LPB136_RS00630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPB136_RS00635	COG0799	negative regulation of ribosome biogenesis
LPB136_RS00640	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LPB136_RS00640	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LPB136_RS00650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LPB136_RS00655	COG1051	belongs to the nudix hydrolase family
LPB136_RS00660	COG0443	Heat shock 70 kDa protein
LPB136_RS00670	COG1252	NADH dehydrogenase
LPB136_RS00695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPB136_RS00705	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LPB136_RS00705	COG3608	succinylglutamate desuccinylase aspartoacylase
LPB136_RS00715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LPB136_RS00745	COG0386	Belongs to the glutathione peroxidase family
LPB136_RS00760	COG0492	ferredoxin-NADP+ reductase activity
LPB136_RS00770	COG0484	heat shock protein binding
LPB136_RS00775	COG1960	acyl-CoA dehydrogenase activity
LPB136_RS00780	COG0183	Belongs to the thiolase family
LPB136_RS00785	COG1024	Enoyl-CoA hydratase
LPB136_RS00785	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPB136_RS00795	COG4152	abc transporter atp-binding protein
LPB136_RS00800	COG1668	transmembrane transport
LPB136_RS00805	COG3264	Mechanosensitive ion channel
LPB136_RS00805	COG1196	nuclear chromosome segregation
LPB136_RS00825	COG0450	alkyl hydroperoxide reductase
LPB136_RS00830	COG3118	belongs to the thioredoxin family
LPB136_RS00840	COG0189	ligase activity
LPB136_RS00850	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LPB136_RS00900	COG0655	NAD(P)H dehydrogenase (quinone) activity
LPB136_RS00905	COG2326	polyphosphate kinase activity
LPB136_RS00920	COG1472	Belongs to the glycosyl hydrolase 3 family
LPB136_RS00940	COG0662	Cupin 2, conserved barrel domain protein
LPB136_RS00940	COG2207	Transcriptional regulator
LPB136_RS01000	COG0681	Belongs to the peptidase S26 family
LPB136_RS01005	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPB136_RS01015	COG1475	DNA binding
LPB136_RS01020	COG1192	Involved in chromosome partitioning
LPB136_RS01025	COG2195	Cleaves the N-terminal amino acid of tripeptides
LPB136_RS01060	COG1611	Belongs to the LOG family
LPB136_RS01085	COG1115	amino acid carrier protein
LPB136_RS01095	COG1960	acyl-CoA dehydrogenase activity
LPB136_RS01100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LPB136_RS01110	COG1187	pseudouridine synthase activity
LPB136_RS01115	COG0343	queuine tRNA-ribosyltransferase activity
LPB136_RS01125	COG0697	spore germination
LPB136_RS01130	COG0825	malonyl-CoA metabolic process
LPB136_RS01140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB136_RS01145	COG2986	histidine ammonia-lyase
LPB136_RS01155	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LPB136_RS01155	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LPB136_RS01160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LPB136_RS01180	COG1090	epimerase
LPB136_RS01235	COG0326	Molecular chaperone. Has ATPase activity
LPB136_RS01250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPB136_RS01280	COG1234	tRNA 3'-trailer cleavage
LPB136_RS01295	COG0540	Belongs to the ATCase OTCase family
LPB136_RS01300	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LPB136_RS01305	COG0659	secondary active sulfate transmembrane transporter activity
LPB136_RS01335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LPB136_RS01340	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPB136_RS01350	COG0564	pseudouridine synthase activity
LPB136_RS01360	COG0542	response to heat
LPB136_RS01375	COG0791	NLP P60 protein
LPB136_RS01380	COG0183	Belongs to the thiolase family
LPB136_RS01430	COG0653	protein targeting
LPB136_RS01445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPB136_RS01455	COG0489	protein tyrosine kinase activity
LPB136_RS01460	COG0824	Thioesterase
LPB136_RS01465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LPB136_RS01470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LPB136_RS01475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LPB136_RS01485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPB136_RS01495	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LPB136_RS01500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPB136_RS01515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LPB136_RS01535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LPB136_RS01540	COG1528	Iron-storage protein
LPB136_RS01565	COG0497	DNA recombination
LPB136_RS01575	COG1216	Glycosyl transferase, family 2
LPB136_RS01580	COG1393	Belongs to the ArsC family
LPB136_RS01585	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LPB136_RS01620	COG3275	phosphorelay sensor kinase activity
LPB136_RS01640	COG3279	Response regulator of the LytR AlgR family
LPB136_RS01655	COG0010	Belongs to the arginase family
LPB136_RS01660	COG1228	amidohydrolase
LPB136_RS01670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LPB136_RS01675	COG0590	tRNA wobble adenosine to inosine editing
LPB136_RS01690	COG0706	membrane insertase activity
LPB136_RS01695	COG0504	CTP synthase activity
LPB136_RS01700	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LPB136_RS01705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPB136_RS01715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPB136_RS01720	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_RS01765	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LPB136_RS01800	COG3813	Protein conserved in bacteria
LPB136_RS01810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LPB136_RS01815	COG2890	protein-(glutamine-N5) methyltransferase activity
LPB136_RS01820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPB136_RS01825	COG0456	acetyltransferase
LPB136_RS01835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPB136_RS01835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPB136_RS01840	COG1011	Hydrolase
LPB136_RS01845	COG0697	spore germination
LPB136_RS01850	COG1739	Uncharacterized protein family UPF0029
LPB136_RS01870	COG0539	negative regulation of cytoplasmic translation
LPB136_RS01875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPB136_RS01930	COG1678	Uncharacterized ACR, COG1678
LPB136_RS01940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPB136_RS01945	COG0514	ATP-dependent DNA helicase (RecQ)
LPB136_RS01960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPB136_RS01970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LPB136_RS01975	COG0714	Associated with various cellular activities
LPB136_RS02015	COG2326	polyphosphate kinase activity
LPB136_RS02030	COG1104	cysteine desulfurase activity
LPB136_RS02065	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LPB136_RS02070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPB136_RS02100	COG2270	Major facilitator Superfamily
LPB136_RS02105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPB136_RS02115	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LPB136_RS02125	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LPB136_RS02135	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LPB136_RS02140	COG1011	Hydrolase
LPB136_RS02180	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LPB136_RS02180	COG0321	lipoyl(octanoyl) transferase activity
LPB136_RS02185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LPB136_RS02200	COG4771	TonB-dependent receptor
LPB136_RS02220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPB136_RS02245	COG0482	sulfurtransferase activity
LPB136_RS02285	COG1595	DNA-templated transcription, initiation
LPB136_RS02290	COG0300	oxidoreductase activity
LPB136_RS02295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LPB136_RS02300	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LPB136_RS02305	COG2996	Protein conserved in bacteria
LPB136_RS02320	COG0179	Fumarylacetoacetate (FAA) hydrolase
LPB136_RS02325	COG1546	Belongs to the CinA family
LPB136_RS02325	COG1058	Belongs to the CinA family
LPB136_RS02330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LPB136_RS02335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LPB136_RS02345	COG0552	protein localization to endoplasmic reticulum
LPB136_RS02350	COG0154	amidase activity
LPB136_RS02355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPB136_RS02370	COG1136	(ABC) transporter
LPB136_RS02380	COG0045	succinate-CoA ligase (ADP-forming) activity
LPB136_RS02385	COG0583	DNA-binding transcription factor activity
LPB136_RS02390	COG1280	lysine exporter protein (LysE YggA)
LPB136_RS02405	COG0556	nucleotide-excision repair
LPB136_RS02425	COG1131	(ABC) transporter
LPB136_RS02460	COG1132	(ABC) transporter
LPB136_RS02470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPB136_RS02480	COG1862	Preprotein translocase
LPB136_RS02490	COG0237	dephospho-CoA kinase activity
LPB136_RS02505	COG0009	L-threonylcarbamoyladenylate synthase
LPB136_RS02540	COG2234	aminopeptidase activity
LPB136_RS02545	COG1120	ATPase activity
LPB136_RS02550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LPB136_RS02555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LPB136_RS02570	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LPB136_RS02580	COG0339	signal peptide processing
LPB136_RS02595	COG1295	ribonuclease BN
LPB136_RS02600	COG0124	histidyl-tRNA synthetase
LPB136_RS02605	COG0302	gtp cyclohydrolase
LPB136_RS02610	COG1278	Cold shock
LPB136_RS02615	COG4895	conserved protein (DUF2196)
LPB136_RS02640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPB136_RS02650	COG2329	Antibiotic biosynthesis monooxygenase
LPB136_RS02660	COG4166	transmembrane transport
LPB136_RS02680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LPB136_RS02690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LPB136_RS02700	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPB136_RS02710	COG0583	DNA-binding transcription factor activity
LPB136_RS02720	COG0105	UTP biosynthetic process
LPB136_RS02725	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LPB136_RS02740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPB136_RS02755	COG1703	isobutyryl-CoA mutase activity
LPB136_RS02760	COG1595	DNA-templated transcription, initiation
LPB136_RS02775	COG0215	cysteine-tRNA ligase activity
LPB136_RS02780	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LPB136_RS02785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LPB136_RS02825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LPB136_RS02830	COG0602	queuosine metabolic process
LPB136_RS02835	COG0433	COG0433 Predicted ATPase
LPB136_RS02865	COG0116	Belongs to the methyltransferase superfamily
LPB136_RS02890	COG0047	phosphoribosylformylglycinamidine synthase activity
LPB136_RS02890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPB136_RS02895	COG2356	endonuclease I
LPB136_RS02900	COG4733	cellulase activity
LPB136_RS02900	COG5297	Belongs to the glycosyl hydrolase family 6
LPB136_RS02905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LPB136_RS02905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPB136_RS02910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LPB136_RS02930	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_RS02935	COG3956	TIGRFAM MazG family protein
LPB136_RS02945	COG0242	peptide deformylase activity
LPB136_RS02955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LPB136_RS02965	COG0463	Glycosyl transferase, family 2
LPB136_RS02970	COG0009	L-threonylcarbamoyladenylate synthase
LPB136_RS02975	COG0617	tRNA 3'-terminal CCA addition
LPB136_RS02985	COG1132	(ABC) transporter
LPB136_RS02990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPB136_RS02995	COG0463	Glycosyl transferase, family 2
LPB136_RS03010	COG4974	Belongs to the 'phage' integrase family
LPB136_RS03030	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LPB136_RS03045	COG0167	dihydroorotate dehydrogenase activity
LPB136_RS03070	COG1730	sister chromatid segregation
LPB136_RS03090	COG0517	IMP dehydrogenase activity
LPB136_RS03090	COG0516	GMP reductase activity
LPB136_RS03120	COG1794	racemase activity, acting on amino acids and derivatives
LPB136_RS03130	COG0668	transmembrane transport
LPB136_RS03140	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LPB136_RS03145	COG1914	H( )-stimulated, divalent metal cation uptake system
LPB136_RS03150	COG2186	Transcriptional regulator
LPB136_RS03160	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_RS03170	COG4771	TonB-dependent receptor
LPB136_RS03190	COG0210	DNA helicase
LPB136_RS03200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPB136_RS03210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LPB136_RS03215	COG0484	heat shock protein binding
LPB136_RS03250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LPB136_RS03275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LPB136_RS03280	COG0083	homoserine kinase activity
LPB136_RS03285	COG0527	aspartate kinase activity
LPB136_RS03285	COG0460	homoserine dehydrogenase
LPB136_RS03295	COG0686	Belongs to the AlaDH PNT family
LPB136_RS03305	COG2204	response regulator
LPB136_RS03310	COG1078	dGTPase activity
LPB136_RS03315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPB136_RS03320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPB136_RS03320	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LPB136_RS03325	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPB136_RS03330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPB136_RS03340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LPB136_RS03345	COG0612	Peptidase, M16
LPB136_RS03350	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_RS03365	COG1607	acyl-coa hydrolase
LPB136_RS03380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPB136_RS03455	COG1522	sequence-specific DNA binding
LPB136_RS03460	COG0022	dehydrogenase e1 component
LPB136_RS03465	COG2130	NADP-dependent
LPB136_RS03475	COG1132	(ABC) transporter
LPB136_RS03480	COG0564	pseudouridine synthase activity
LPB136_RS03485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB136_RS03490	COG2814	Major facilitator Superfamily
LPB136_RS03505	COG3279	Response regulator of the LytR AlgR family
LPB136_RS03510	COG3275	phosphorelay sensor kinase activity
LPB136_RS03525	COG1136	(ABC) transporter
LPB136_RS03530	COG0577	efflux transmembrane transporter activity
LPB136_RS03530	COG1136	(ABC) transporter
LPB136_RS03545	COG1309	transcriptional regulator
LPB136_RS03560	COG1979	alcohol dehydrogenase
LPB136_RS03590	COG2249	NAD(P)H dehydrogenase (quinone) activity
LPB136_RS03605	COG1733	regulation of RNA biosynthetic process
LPB136_RS03615	COG4181	ATPase activity
LPB136_RS03655	COG0352	thiamine-phosphate diphosphorylase activity
LPB136_RS03665	COG2066	Belongs to the glutaminase family
LPB136_RS03680	COG1388	LysM domain
LPB136_RS03680	COG0791	NLP P60 protein
LPB136_RS03730	COG0012	GTP binding
LPB136_RS03735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LPB136_RS03745	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LPB136_RS03755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LPB136_RS03765	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LPB136_RS03785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPB136_RS03790	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LPB136_RS03820	COG4452	Inner membrane protein CreD
LPB136_RS03825	COG4682	membrane
LPB136_RS03835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LPB136_RS03835	COG0140	phosphoribosyl-ATP diphosphatase activity
LPB136_RS03840	COG0107	imidazoleglycerol-phosphate synthase activity
LPB136_RS03845	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LPB136_RS03855	COG0131	Imidazoleglycerol-phosphate dehydratase
LPB136_RS03860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LPB136_RS03865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LPB136_RS03870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPB136_RS03875	COG0697	spore germination
LPB136_RS03890	COG1217	gtp-binding protein TYPA
LPB136_RS03905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LPB136_RS03910	COG0438	transferase activity, transferring glycosyl groups
LPB136_RS03915	COG3959	Transketolase, thiamine diphosphate binding domain
LPB136_RS03945	COG2195	Cleaves the N-terminal amino acid of tripeptides
LPB136_RS03960	COG0359	binds to the 23S rRNA
LPB136_RS03965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LPB136_RS03970	COG0360	Binds together with S18 to 16S ribosomal RNA
LPB136_RS03980	COG0579	oxidoreductase
LPB136_RS03990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPB136_RS04010	COG4628	conserved protein (DUF2132)
LPB136_RS04015	COG0006	proline dipeptidase activity
LPB136_RS04020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LPB136_RS04035	COG1322	Protein conserved in bacteria
LPB136_RS04040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LPB136_RS04055	COG1899	peptidyl-lysine modification to peptidyl-hypusine
LPB136_RS04060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPB136_RS04060	COG3153	acetyltransferase
LPB136_RS04065	COG0010	Belongs to the arginase family
LPB136_RS04085	COG0598	Magnesium transport protein CorA
LPB136_RS04100	COG0542	response to heat
LPB136_RS04120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LPB136_RS04130	COG0424	maF-like protein
LPB136_RS04135	COG3958	Transketolase
LPB136_RS04150	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LPB136_RS04155	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LPB136_RS04160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LPB136_RS04180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPB136_RS04190	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LPB136_RS04220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LPB136_RS04225	COG1022	Amp-dependent synthetase and ligase
LPB136_RS04230	COG1022	Amp-dependent synthetase and ligase
LPB136_RS04250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPB136_RS04255	COG3263	regulation of cellular component size
LPB136_RS04260	COG4953	penicillin-binding protein 1C
LPB136_RS04265	COG2373	Large extracellular alpha-helical protein
LPB136_RS04270	COG0513	Belongs to the DEAD box helicase family
LPB136_RS04300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LPB136_RS04310	COG4974	Belongs to the 'phage' integrase family
LPB136_RS04410	COG0456	acetyltransferase
LPB136_RS04410	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LPB136_RS04425	COG3279	Response regulator of the LytR AlgR family
LPB136_RS04430	COG3275	phosphorelay sensor kinase activity
LPB136_RS04450	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LPB136_RS04455	COG1690	Belongs to the RtcB family
LPB136_RS04480	COG3012	SEC-C Motif Domain Protein
LPB136_RS04490	COG1131	(ABC) transporter
LPB136_RS04495	COG1363	Peptidase, m42
LPB136_RS04525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPB136_RS04530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LPB136_RS04540	COG2204	response regulator
LPB136_RS04545	COG3852	Histidine kinase
LPB136_RS04555	COG1253	flavin adenine dinucleotide binding
LPB136_RS04560	COG0783	Belongs to the Dps family
LPB136_RS04570	COG0488	(ABC) transporter
LPB136_RS04585	COG0514	ATP-dependent DNA helicase (RecQ)
LPB136_RS04590	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LPB136_RS04590	COG0517	IMP dehydrogenase activity
LPB136_RS04595	COG0805	protein transport
LPB136_RS04605	COG1137	ATPase activity
LPB136_RS04610	COG1183	phosphatidylcholine synthase activity
LPB136_RS04630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LPB136_RS04690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LPB136_RS04700	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LPB136_RS04710	COG0463	Glycosyl transferase, family 2
LPB136_RS04715	COG2089	acid synthase
LPB136_RS04720	COG1083	cytidylyl-transferase
LPB136_RS04735	COG1216	Glycosyl transferase, family 2
LPB136_RS04770	COG2885	chlorophyll binding
LPB136_RS04800	COG1418	mRNA catabolic process
LPB136_RS04835	COG1047	Peptidyl-prolyl cis-trans
LPB136_RS04840	COG0156	8-amino-7-oxononanoate synthase activity
LPB136_RS04865	COG4977	sequence-specific DNA binding
LPB136_RS04885	COG0783	Belongs to the Dps family
LPB136_RS04890	COG0668	transmembrane transport
LPB136_RS04910	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LPB136_RS04930	COG0714	Associated with various cellular activities
LPB136_RS04960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LPB136_RS04965	COG0668	transmembrane transport
LPB136_RS05005	COG0813	purine-nucleoside phosphorylase activity
LPB136_RS05025	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LPB136_RS05045	COG0534	Mate efflux family protein
LPB136_RS05050	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LPB136_RS05060	COG1674	ftsk spoiiie
LPB136_RS05075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LPB136_RS05075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LPB136_RS05080	COG3340	Belongs to the peptidase S51 family
LPB136_RS05130	COG2318	DinB family
LPB136_RS05140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB136_RS05140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB136_RS05150	COG0401	homolog of Blt101
LPB136_RS05165	COG0277	FAD linked oxidase domain protein
LPB136_RS05165	COG0247	lactate metabolic process
LPB136_RS05175	COG0525	valine-tRNA ligase activity
LPB136_RS05190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPB136_RS05195	COG0436	Aminotransferase
LPB136_RS05200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPB136_RS05205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPB136_RS05215	COG1215	transferase activity, transferring glycosyl groups
LPB136_RS05230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LPB136_RS05260	COG3876	Protein conserved in bacteria
LPB136_RS05290	COG0018	arginyl-trna synthetase
LPB136_RS05300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPB136_RS05345	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LPB136_RS05355	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
LPB136_RS05365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPB136_RS05385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPB136_RS05390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPB136_RS05395	COG1595	DNA-templated transcription, initiation
LPB136_RS05410	COG4771	TonB-dependent receptor
LPB136_RS05455	COG3275	phosphorelay sensor kinase activity
LPB136_RS05460	COG1408	metallophosphoesterase
LPB136_RS05465	COG3279	Response regulator of the LytR AlgR family
LPB136_RS05475	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LPB136_RS05480	COG0626	cystathionine gamma-synthase activity
LPB136_RS05505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPB136_RS05510	COG0673	inositol 2-dehydrogenase activity
LPB136_RS05515	COG1250	3-hydroxyacyl-CoA dehydrogenase
LPB136_RS05530	COG1136	(ABC) transporter
LPB136_RS05530	COG0577	efflux transmembrane transporter activity
LPB136_RS05535	COG1136	(ABC) transporter
LPB136_RS05535	COG0577	efflux transmembrane transporter activity
LPB136_RS05540	COG1136	(ABC) transporter
LPB136_RS05545	COG3011	Protein conserved in bacteria
LPB136_RS05565	COG2897	thiosulfate sulfurtransferase activity
LPB136_RS05570	COG0189	ligase activity
LPB136_RS05575	COG1301	dicarboxylic acid transport
LPB136_RS05610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LPB136_RS05615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LPB136_RS05620	COG1702	phosphate starvation-inducible protein PhoH
LPB136_RS05650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPB136_RS05655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LPB136_RS05710	COG0592	DNA-directed DNA polymerase activity
LPB136_RS05725	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
LPB136_RS05730	COG0405	Gamma-glutamyltransferase
LPB136_RS05745	COG0564	pseudouridine synthase activity
LPB136_RS05750	COG0336	Belongs to the RNA methyltransferase TrmD family
LPB136_RS05755	COG0335	large ribosomal subunit rRNA binding
LPB136_RS05765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LPB136_RS05805	COG2197	response regulator
LPB136_RS05825	COG0488	(ABC) transporter
LPB136_RS05845	COG0446	pyridine nucleotide-disulphide oxidoreductase
LPB136_RS05845	COG1902	pentaerythritol trinitrate reductase activity
LPB136_RS05855	COG1846	Transcriptional regulator
LPB136_RS05930	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LPB136_RS05940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LPB136_RS05950	COG0217	transcriptional regulatory protein
LPB136_RS05975	COG4948	Mandelate Racemase Muconate Lactonizing
LPB136_RS05990	COG1575	Belongs to the MenA family. Type 1 subfamily
LPB136_RS05995	COG2181	nitrate reductase activity
LPB136_RS05995	COG0247	lactate metabolic process
LPB136_RS06000	COG0247	lactate metabolic process
LPB136_RS06000	COG2181	nitrate reductase activity
LPB136_RS06010	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPB136_RS06015	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LPB136_RS06025	COG1803	Methylglyoxal synthase
LPB136_RS06035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPB136_RS06040	COG0205	6-phosphofructokinase activity
LPB136_RS06045	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPB136_RS06055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LPB136_RS06070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB136_RS06150	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LPB136_RS06155	COG0085	RNA polymerase activity
LPB136_RS06160	COG0222	ribosome binding
LPB136_RS06165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LPB136_RS06170	COG0081	regulation of translation
LPB136_RS06175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LPB136_RS06225	COG4974	Belongs to the 'phage' integrase family
LPB136_RS06230	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LPB136_RS06290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LPB136_RS06295	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPB136_RS06310	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPB136_RS06315	COG0408	coproporphyrinogen oxidase activity
LPB136_RS06330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LPB136_RS06335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LPB136_RS06345	COG0113	porphobilinogen synthase activity
LPB136_RS06355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LPB136_RS06370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LPB136_RS06375	COG1981	membrane
LPB136_RS06380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LPB136_RS06385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPB136_RS06390	COG1902	pentaerythritol trinitrate reductase activity
LPB136_RS06400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPB136_RS06405	COG0259	pyridoxamine-phosphate oxidase activity
LPB136_RS06430	COG1663	tetraacyldisaccharide 4'-kinase activity
LPB136_RS06435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LPB136_RS06450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPB136_RS06475	COG1760	l-serine dehydratase
LPB136_RS06480	COG3022	response to hydroperoxide
LPB136_RS06490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LPB136_RS06490	COG1333	cytochrome c biogenesis protein
LPB136_RS06505	COG4464	protein tyrosine phosphatase activity
LPB136_RS06515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPB136_RS06520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LPB136_RS06535	COG0295	cytidine deaminase activity
LPB136_RS06545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPB136_RS06550	COG0519	Catalyzes the synthesis of GMP from XMP
LPB136_RS06550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPB136_RS06555	COG1388	LysM domain
LPB136_RS06555	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPB136_RS06560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LPB136_RS06570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LPB136_RS06590	COG0673	inositol 2-dehydrogenase activity
LPB136_RS06625	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LPB136_RS06630	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LPB136_RS06635	COG1482	cell wall glycoprotein biosynthetic process
LPB136_RS06655	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LPB136_RS06660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LPB136_RS06665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPB136_RS06680	COG0285	dihydrofolate synthase activity
LPB136_RS06690	COG0848	biopolymer transport protein
LPB136_RS06700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LPB136_RS06715	COG1960	acyl-CoA dehydrogenase activity
LPB136_RS06720	COG0101	tRNA pseudouridine synthase activity
LPB136_RS06775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LPB136_RS06780	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LPB136_RS06785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LPB136_RS06790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LPB136_RS06810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LPB136_RS06830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPB136_RS06865	COG0174	glutamine synthetase
LPB136_RS06955	COG2010	Cytochrome c
LPB136_RS06975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPB136_RS06980	COG2217	Heavy metal translocating P-type atpase
LPB136_RS07000	COG2264	protein methyltransferase activity
LPB136_RS07005	COG0149	triose-phosphate isomerase activity
LPB136_RS07010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB136_RS07015	COG0601	transmembrane transport
LPB136_RS07025	COG0284	orotidine-5'-phosphate decarboxylase activity
LPB136_RS07030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LPB136_RS07050	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LPB136_RS07060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LPB136_RS07060	COG1703	isobutyryl-CoA mutase activity
LPB136_RS07060	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LPB136_RS07090	COG0159	tryptophan synthase activity
LPB136_RS07095	COG0133	tryptophan synthase activity
LPB136_RS07100	COG0135	phosphoribosylanthranilate isomerase activity
LPB136_RS07105	COG0134	indole-3-glycerol-phosphate synthase activity
LPB136_RS07115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPB136_RS07120	COG0512	Glutamine amidotransferase of anthranilate synthase
LPB136_RS07125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPB136_RS07155	COG1397	ADP-ribosylglycohydrolase
LPB136_RS07160	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPB136_RS07165	COG0154	amidase activity
LPB136_RS07175	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LPB136_RS07180	COG0187	DNA topoisomerase II activity
LPB136_RS07200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPB136_RS07205	COG0563	adenylate kinase activity
LPB136_RS07210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPB136_RS07245	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LPB136_RS07250	COG2814	Major facilitator Superfamily
LPB136_RS07275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LPB136_RS07295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPB136_RS07300	COG0848	biopolymer transport protein
LPB136_RS07305	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LPB136_RS07315	COG1132	(ABC) transporter
LPB136_RS07320	COG0101	tRNA pseudouridine synthase activity
LPB136_RS07340	COG2197	response regulator
LPB136_RS07360	COG1253	flavin adenine dinucleotide binding
LPB136_RS07385	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LPB136_RS07400	COG0589	response to stress
LPB136_RS07425	COG0668	transmembrane transport
LPB136_RS07440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LPB136_RS07450	COG3279	Response regulator of the LytR AlgR family
LPB136_RS07455	COG3275	phosphorelay sensor kinase activity
LPB136_RS07460	COG1629	transport
LPB136_RS07460	COG4206	TonB-dependent receptor
LPB136_RS07475	COG1705	Flagellar rod assembly protein muramidase FlgJ
LPB136_RS07480	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LPB136_RS07490	COG0488	(ABC) transporter
LPB136_RS07520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LPB136_RS07535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LPB136_RS07565	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LPB136_RS07570	COG0459	protein refolding
LPB136_RS07615	COG0138	bifunctional purine biosynthesis protein purh
LPB136_RS07620	COG1077	Cell shape determining protein MreB Mrl
LPB136_RS07635	COG0768	penicillin binding
LPB136_RS07640	COG0772	Belongs to the SEDS family
LPB136_RS07645	COG0268	Binds directly to 16S ribosomal RNA
LPB136_RS07655	COG0442	prolyl-tRNA aminoacylation
LPB136_RS07670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LPB136_RS07675	COG2226	methyltransferase
LPB136_RS07695	COG1595	DNA-templated transcription, initiation
LPB136_RS07700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPB136_RS07705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LPB136_RS07720	COG1271	oxidase subunit
LPB136_RS07725	COG1294	oxidase, subunit
LPB136_RS07755	COG1610	YqeY-like protein
LPB136_RS07760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LPB136_RS07775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPB136_RS07780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LPB136_RS07790	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LPB136_RS07795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPB136_RS07800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LPB136_RS07805	COG0768	penicillin binding
LPB136_RS07815	COG0275	rRNA processing
LPB136_RS07820	COG2001	Belongs to the MraZ family
LPB136_RS07830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LPB136_RS07835	COG0564	pseudouridine synthase activity
LPB136_RS07840	COG1012	belongs to the aldehyde dehydrogenase family
LPB136_RS07865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LPB136_RS07875	COG0612	Peptidase, M16
LPB136_RS07880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LPB136_RS07905	COG1054	Belongs to the UPF0176 family
LPB136_RS07920	COG2226	methyltransferase
LPB136_RS07930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LPB136_RS07975	COG2824	Alkylphosphonate utilization operon protein PhnA
LPB136_RS08000	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LPB136_RS08005	COG2363	Small membrane protein
LPB136_RS08015	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LPB136_RS08040	COG1757	Na H antiporter
LPB136_RS08050	COG1490	D-aminoacyl-tRNA deacylase activity
LPB136_RS08075	COG1522	sequence-specific DNA binding
LPB136_RS08080	COG0626	cystathionine gamma-synthase activity
LPB136_RS08085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LPB136_RS08090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LPB136_RS08095	COG0228	four-way junction DNA binding
LPB136_RS08115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPB136_RS08120	COG1131	(ABC) transporter
LPB136_RS08130	COG0321	lipoyl(octanoyl) transferase activity
LPB136_RS08145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPB136_RS08155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LPB136_RS08165	COG0463	Glycosyl transferase, family 2
LPB136_RS08175	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LPB136_RS08175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPB136_RS08185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPB136_RS08200	COG2081	HI0933 family
LPB136_RS08220	COG0823	Involved in the tonB-independent uptake of proteins
LPB136_RS08220	COG1506	peptidase
LPB136_RS08225	COG3104	oligopeptide transport
LPB136_RS08230	COG4232	protein-disulfide reductase activity
LPB136_RS08235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPB136_RS08240	COG2333	competence protein COMEC
LPB136_RS08240	COG0658	competence protein
LPB136_RS08245	COG0791	NLP P60 protein
LPB136_RS08250	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPB136_RS08260	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LPB136_RS08285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LPB136_RS08300	COG1215	transferase activity, transferring glycosyl groups
LPB136_RS08310	COG1609	Transcriptional regulator
LPB136_RS08335	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LPB136_RS08340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LPB136_RS08360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LPB136_RS08400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPB136_RS08410	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LPB136_RS08415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LPB136_RS08420	COG0339	signal peptide processing
LPB136_RS08440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPB136_RS08455	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LPB136_RS08475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LPB136_RS08480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPB136_RS08485	COG0006	proline dipeptidase activity
LPB136_RS08490	COG0006	proline dipeptidase activity
LPB136_RS08495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LPB136_RS08505	COG3938	Belongs to the proline racemase family
LPB136_RS08535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LPB136_RS08540	COG1185	polyribonucleotide nucleotidyltransferase activity
LPB136_RS08545	COG4974	Belongs to the 'phage' integrase family
LPB136_RS08675	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPB136_RS08750	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPB136_RS08795	COG1428	Deoxynucleoside kinase
LPB136_RS08810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LPB136_RS08815	COG0358	DNA primase activity
LPB136_RS08820	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LPB136_RS08830	COG0544	peptidyl-prolyl cis-trans isomerase activity
LPB136_RS08835	COG1950	PFAM Membrane protein of
LPB136_RS08860	COG0596	Alpha beta hydrolase
LPB136_RS08865	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LPB136_RS08875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LPB136_RS08885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LPB136_RS08905	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LPB136_RS08915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPB136_RS08925	COG0745	RESPONSE REGULATOR receiver
LPB136_RS08930	COG5002	protein histidine kinase activity
LPB136_RS08940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPB136_RS08965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPB136_RS08975	COG1160	GTP binding
LPB136_RS08995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPB136_RS09000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPB136_RS09010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LPB136_RS09025	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LPB136_RS09030	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LPB136_RS09045	COG2363	Small membrane protein
LPB136_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_RS09090	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_RS09095	COG1960	acyl-CoA dehydrogenase activity
LPB136_RS09110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPB136_RS09115	COG0415	Belongs to the DNA photolyase family
LPB136_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
LPB136_RS09145	COG0702	epimerase
LPB136_RS09155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LPB136_RS09165	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LPB136_RS09195	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LPB136_RS09225	COG4585	Histidine kinase
LPB136_RS09245	COG0501	Belongs to the peptidase M48B family
LPB136_RS09255	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LPB136_RS09275	COG2226	methyltransferase
LPB136_RS09280	COG1477	protein flavinylation
LPB136_RS09305	COG0513	Belongs to the DEAD box helicase family
LPB136_RS09350	COG0668	transmembrane transport
LPB136_RS09360	COG1214	PFAM Peptidase M22, glycoprotease
LPB136_RS09375	COG2322	membrane
LPB136_RS09380	COG1999	signal sequence binding
LPB136_RS09400	COG1845	cytochrome c oxidase, subunit III
LPB136_RS09405	COG0109	protoheme IX farnesyltransferase activity
LPB136_RS09440	COG0509	glycine decarboxylation via glycine cleavage system
LPB136_RS09450	COG0632	four-way junction helicase activity
LPB136_RS09475	COG2814	Major facilitator Superfamily
LPB136_RS09480	COG0314	molybdopterin synthase activity
LPB136_RS09500	COG0746	molybdenum cofactor guanylyltransferase activity
LPB136_RS09500	COG0315	cyclic pyranopterin monophosphate synthase activity
LPB136_RS09510	COG0303	'Molybdopterin
LPB136_RS09520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LPB136_RS09525	COG0322	excinuclease ABC activity
LPB136_RS09530	COG1752	Esterase of the alpha-beta hydrolase superfamily
LPB136_RS09550	COG1530	ribonuclease E activity
LPB136_RS09555	COG0776	regulation of translation
LPB136_RS09560	COG1194	a g-specific adenine glycosylase
LPB136_RS09565	COG0629	single-stranded DNA binding
LPB136_RS09595	COG0697	spore germination
LPB136_RS09600	COG0612	Peptidase, M16
LPB136_RS09605	COG0612	Peptidase, M16
LPB136_RS09610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LPB136_RS09615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LPB136_RS09640	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LPB136_RS09650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LPB136_RS09655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPB136_RS09665	COG0484	heat shock protein binding
LPB136_RS09675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPB136_RS09695	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LPB136_RS09700	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LPB136_RS09710	COG1805	sodium ion transport
LPB136_RS09725	COG2967	ApaG domain
LPB136_RS09740	COG1012	belongs to the aldehyde dehydrogenase family
LPB136_RS09750	COG0513	Belongs to the DEAD box helicase family
LPB136_RS09755	COG0357	Ribosomal RNA small subunit methyltransferase G
LPB136_RS09760	COG3239	Fatty acid desaturase
LPB136_RS09765	COG0436	Aminotransferase
LPB136_RS09780	COG0084	hydrolase, TatD family'
LPB136_RS09825	COG3119	arylsulfatase activity
LPB136_RS09830	COG1114	Component of the transport system for branched-chain amino acids
LPB136_RS09850	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LPB136_RS09870	COG0719	Fe-S assembly protein
LPB136_RS09880	COG0396	ATPase activity
LPB136_RS09885	COG0719	Fe-S assembly protein
LPB136_RS09890	COG0688	phosphatidylethanolamine metabolic process
LPB136_RS09895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPB136_RS09915	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPB136_RS09940	COG3292	Two component regulator propeller
LPB136_RS09940	COG0745	RESPONSE REGULATOR receiver
LPB136_RS09940	COG2205	protein histidine kinase activity
LPB136_RS09960	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPB136_RS09965	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LPB136_RS09970	COG0193	aminoacyl-tRNA hydrolase activity
LPB136_RS09975	COG0720	synthase
LPB136_RS09985	COG0534	Mate efflux family protein
LPB136_RS10030	COG0166	Belongs to the GPI family
LPB136_RS10050	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LPB136_RS10060	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LPB136_RS10065	COG0633	Ferredoxin
LPB136_RS10075	COG0492	ferredoxin-NADP+ reductase activity
LPB136_RS10085	COG0489	protein tyrosine kinase activity
LPB136_RS10095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPB136_RS10110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LPB136_RS10115	COG1652	LysM domain
LPB136_RS10125	COG1561	YicC-like family, N-terminal region
LPB136_RS10130	COG0194	GDP metabolic process
LPB136_RS10135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LPB136_RS10140	COG4942	peptidase
LPB136_RS10150	COG2258	MOSC domain
LPB136_RS10155	COG1970	mechanosensitive ion channel activity
LPB136_RS10160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LPB136_RS10200	COG0626	cystathionine gamma-synthase activity
LPB136_RS10215	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LPB136_RS10225	COG0527	aspartate kinase activity
LPB136_RS10235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LPB136_RS10240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LPB136_RS10250	COG0156	8-amino-7-oxononanoate synthase activity
LPB136_RS10255	COG1074	ATP-dependent DNA helicase activity
LPB136_RS10270	COG4771	TonB-dependent receptor
LPB136_RS10290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LPB136_RS10305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPB136_RS10310	COG0463	Glycosyl transferase, family 2
LPB136_RS10325	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LPB136_RS10340	COG2095	MarC family integral membrane protein
LPB136_RS10350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPB136_RS10360	COG0297	glycogen (starch) synthase activity
LPB136_RS10365	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LPB136_RS10370	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LPB136_RS10390	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LPB136_RS10415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPB136_RS10420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LPB136_RS10420	COG1328	CTP reductase activity
LPB136_RS10425	COG1278	Cold shock
LPB136_RS10430	COG3279	Response regulator of the LytR AlgR family
LPB136_RS10435	COG0745	RESPONSE REGULATOR receiver
LPB136_RS10435	COG2972	Histidine kinase
LPB136_RS10440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LPB136_RS10445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPB136_RS10470	COG1253	flavin adenine dinucleotide binding
LPB136_RS10490	COG2151	metal-sulfur cluster biosynthetic enzyme
LPB136_RS10495	COG2166	iron-sulfur cluster assembly
LPB136_RS10515	COG1388	LysM domain
LPB136_RS10515	COG0741	lytic transglycosylase activity
LPB136_RS10520	COG0708	Exodeoxyribonuclease III
LPB136_RS10535	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LPB136_RS10540	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LPB136_RS10550	COG1774	PSP1 C-terminal conserved region
LPB136_RS10595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPB136_RS10605	COG1505	serine-type exopeptidase activity
LPB136_RS10610	COG2072	flavoprotein involved in K transport
LPB136_RS10615	COG3590	peptidase
LPB136_RS10620	COG3842	ATPase activity
LPB136_RS10655	COG4221	oxidoreductase activity
LPB136_RS10695	COG1012	belongs to the aldehyde dehydrogenase family
LPB136_RS10700	COG1446	asparaginase
LPB136_RS10710	COG0300	oxidoreductase activity
LPB136_RS10725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LPB136_RS10745	COG0756	dUTP diphosphatase activity
LPB136_RS10755	COG2153	protein acetylation
LPB136_RS10760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LPB136_RS10765	COG1187	pseudouridine synthase activity
LPB136_RS10785	COG2153	protein acetylation
LPB136_RS10790	COG0698	ribose 5-phosphate isomerase
LPB136_RS10795	COG1597	lipid kinase activity
LPB136_RS10800	COG0557	exoribonuclease II activity
LPB136_RS10810	COG0393	Putative heavy-metal-binding
LPB136_RS10820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPB136_RS10850	COG0445	tRNA wobble uridine modification
LPB136_RS10855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LPB136_RS10880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPB136_RS10895	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPB136_RS10945	COG0628	permease
LPB136_RS10965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LPB136_RS10985	COG0488	(ABC) transporter
LPB136_RS10995	COG0745	RESPONSE REGULATOR receiver
LPB136_RS11000	COG5002	protein histidine kinase activity
LPB136_RS11005	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LPB136_RS11010	COG0151	Belongs to the GarS family
LPB136_RS11065	COG0793	Belongs to the peptidase S41A family
LPB136_RS11070	COG0594	ribonuclease P activity
LPB136_RS11115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LPB136_RS11120	COG1757	Na H antiporter
LPB136_RS11140	COG1538	Outer membrane efflux protein
LPB136_RS11150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPB136_RS11160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LPB136_RS11190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LPB136_RS11195	COG1053	succinate dehydrogenase
LPB136_RS11205	COG0300	oxidoreductase activity
LPB136_RS11210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPB136_RS11225	COG1040	competence protein
LPB136_RS11235	COG0423	glycine-tRNA ligase activity
LPB136_RS11250	COG0006	proline dipeptidase activity
LPB136_RS11255	COG0513	Belongs to the DEAD box helicase family
LPB136_RS11340	COG2217	Heavy metal translocating P-type atpase
LPB136_RS11375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPB136_RS11385	COG2217	Heavy metal translocating P-type atpase
LPB136_RS11445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LPB136_RS11450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LPB136_RS11455	COG0066	3-isopropylmalate dehydratase activity
LPB136_RS11465	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LPB136_RS11470	COG0004	ammonium transporteR
LPB136_RS11475	COG0347	Belongs to the P(II) protein family
LPB136_RS11485	COG0067	glutamate synthase
LPB136_RS11485	COG0069	glutamate synthase activity
LPB136_RS11485	COG0070	glutamate synthase
LPB136_RS11495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LPB136_RS11500	COG0165	Argininosuccinate lyase
LPB136_RS11510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LPB136_RS11520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LPB136_RS11525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LPB136_RS11530	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LPB136_RS11535	COG0137	argininosuccinate synthase activity
LPB136_RS11545	COG0129	dihydroxy-acid dehydratase activity
LPB136_RS11550	COG0028	Belongs to the TPP enzyme family
LPB136_RS11560	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LPB136_RS11565	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LPB136_RS11570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPB136_RS11590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LPB136_RS11625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPB136_RS11650	COG0356	it plays a direct role in the translocation of protons across the membrane
LPB136_RS11655	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LPB136_RS11660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LPB136_RS11665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LPB136_RS11670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LPB136_RS11675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LPB136_RS11680	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LPB136_RS11705	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LPB136_RS11705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPB136_RS11720	COG1573	uracil-dna glycosylase
LPB136_RS11735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LPB136_RS11740	COG2020	methyltransferase activity
LPB136_RS11765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPB136_RS11775	COG1288	antiporter activity
LPB136_RS11785	COG0584	glycerophosphoryl diester phosphodiesterase
LPB136_RS11795	COG1629	transport
LPB136_RS11800	COG0196	riboflavin kinase activity
LPB136_RS11805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPB136_RS11825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LPB136_RS11830	COG2239	Acts as a magnesium transporter
LPB136_RS11840	COG4585	Histidine kinase
LPB136_RS11850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPB136_RS11855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPB136_RS11875	COG1595	DNA-templated transcription, initiation
LPB136_RS11885	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LPB136_RS11890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LPB136_RS11910	COG1999	signal sequence binding
LPB136_RS11930	COG2268	Band 7 protein
LPB136_RS11965	COG0495	leucyl-tRNA aminoacylation
LPB136_RS11975	COG1946	Acyl-CoA thioesterase
LPB136_RS11990	COG1381	Involved in DNA repair and RecF pathway recombination
LPB136_RS12000	COG2954	triphosphatase activity
LPB136_RS12005	COG1272	protein, Hemolysin III
LPB136_RS12025	COG0667	Aldo Keto reductase
LPB136_RS12040	COG0126	phosphoglycerate kinase activity
LPB136_RS12045	COG0470	DNA polymerase III
LPB136_RS12055	COG1024	Enoyl-CoA hydratase
LPB136_RS12080	COG2169	Transcriptional regulator
LPB136_RS12085	COG1418	mRNA catabolic process
LPB136_RS12105	COG3655	Transcriptional regulator
LPB136_RS12140	COG0629	single-stranded DNA binding
LPB136_RS12165	COG1629	transport
LPB136_RS12165	COG4206	TonB-dependent receptor
LPB136_RS12200	COG0469	pyruvate kinase activity
LPB136_RS12210	COG0571	ribonuclease III activity
LPB136_RS12215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPB136_RS12220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LPB136_RS12230	COG3341	Caulimovirus viroplasmin
LPB136_RS12230	COG0328	RNA-DNA hybrid ribonuclease activity
LPB136_RS12270	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LPB136_RS12285	COG2267	carboxylic ester hydrolase activity
LPB136_RS12295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB136_RS12295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPB136_RS12300	COG1619	proteins homologs of microcin C7 resistance protein MccF
LPB136_RS12310	COG0792	nuclease activity
LPB136_RS12325	COG0300	oxidoreductase activity
LPB136_RS12350	COG1061	Type III restriction enzyme res subunit
LPB136_RS12360	COG0288	reversible hydration of carbon dioxide
LPB136_RS12365	COG0659	secondary active sulfate transmembrane transporter activity
LPB136_RS12390	COG2304	oxidoreductase activity
LPB136_RS12395	COG2304	oxidoreductase activity
LPB136_RS12410	COG0714	Associated with various cellular activities
LPB136_RS12415	COG4771	TonB-dependent receptor
LPB136_RS12435	COG0793	Belongs to the peptidase S41A family
LPB136_RS12450	COG1522	sequence-specific DNA binding
LPB136_RS12455	COG0439	Biotin carboxylase
LPB136_RS12460	COG0511	ligase activity, forming carbon-carbon bonds
LPB136_RS12465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPB136_RS12470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LPB136_RS12480	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LPB136_RS12505	COG1309	transcriptional regulator
LPB136_RS12545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPB136_RS12560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPB136_RS12565	COG1968	undecaprenyl-diphosphatase activity
LPB136_RS12575	COG2177	Part of the ABC transporter FtsEX involved in
LPB136_RS12580	COG0346	lactoylglutathione lyase activity
LPB136_RS12605	COG4585	Histidine kinase
LPB136_RS12615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LPB136_RS12620	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPB136_RS12625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPB136_RS12630	COG0481	GTPase activity
LPB136_RS12640	COG0252	asparaginase activity
LPB136_RS12645	COG0811	peptide transport
LPB136_RS12655	COG0848	biopolymer transport protein
LPB136_RS12675	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LPB136_RS12680	COG0017	Asparaginyl-tRNA synthetase
LPB136_RS12690	COG0233	cytoplasmic translational termination
LPB136_RS12695	COG0528	UMP kinase activity
LPB136_RS12700	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LPB136_RS12705	COG0052	Belongs to the universal ribosomal protein uS2 family
LPB136_RS12710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LPB136_RS12715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LPB136_RS12725	COG0564	pseudouridine synthase activity
LPB136_RS12740	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPB136_RS12740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPB136_RS12745	COG1408	metallophosphoesterase
LPB136_RS12775	COG0779	Required for maturation of 30S ribosomal subunits
LPB136_RS12780	COG0195	Participates in both transcription termination and antitermination
LPB136_RS12785	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LPB136_RS12795	COG3474	cytochrome
LPB136_RS12800	COG0437	4 iron, 4 sulfur cluster binding
LPB136_RS12830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LPB136_RS12835	COG2255	four-way junction helicase activity
LPB136_RS12850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPB136_RS12850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPB136_RS12890	COG2226	methyltransferase
LPB136_RS12900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LPB136_RS12920	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
LPB136_RS12940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LPB136_RS12945	COG0563	adenylate kinase activity
LPB136_RS12960	COG0606	chelatase, subunit chli
LPB136_RS12970	COG4232	protein-disulfide reductase activity
LPB136_RS12975	COG0037	tRNA processing
LPB136_RS12985	COG4771	TonB-dependent receptor
LPB136_RS12995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPB136_RS13000	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LPB136_RS13005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LPB136_RS13010	COG4771	TonB-dependent receptor
LPB136_RS13015	COG0022	dehydrogenase e1 component
LPB136_RS13015	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPB136_RS13020	COG2086	electron transfer activity
LPB136_RS13025	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LPB136_RS13035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LPB136_RS13040	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LPB136_RS13050	COG0436	Aminotransferase
LPB136_RS13055	COG0287	Prephenate dehydrogenase
LPB136_RS13060	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LPB136_RS13065	COG1162	GTPase activity
LPB136_RS13070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LPB136_RS13075	COG0191	fructose-bisphosphate aldolase activity
LPB136_RS13085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LPB136_RS13090	COG1428	Deoxynucleoside kinase
LPB136_RS13125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LPB136_RS13135	COG0527	aspartate kinase activity
LPB136_RS13135	COG0460	homoserine dehydrogenase
LPB136_RS13145	COG1959	2 iron, 2 sulfur cluster binding
LPB136_RS13155	COG0175	sulfate reduction
LPB136_RS13160	COG0175	sulfate reduction
LPB136_RS13170	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LPB136_RS13180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LPB136_RS13180	COG1648	precorrin-2 dehydrogenase activity
LPB136_RS13185	COG0492	ferredoxin-NADP+ reductase activity
LPB136_RS13190	COG0633	Ferredoxin
LPB136_RS13195	COG1045	serine acetyltransferase
LPB136_RS13210	COG2329	Antibiotic biosynthesis monooxygenase
LPB136_RS13220	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LPB136_RS13245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LPB136_RS13255	COG0519	Catalyzes the synthesis of GMP from XMP
LPB136_RS13270	COG4221	oxidoreductase activity
LPB136_RS13295	COG3279	Response regulator of the LytR AlgR family
LPB136_RS13320	COG1187	pseudouridine synthase activity
LPB136_RS13340	COG1032	radical SAM domain protein
LPB136_RS13370	COG1595	DNA-templated transcription, initiation
LPB136_RS13375	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LPB136_RS13400	COG2884	Cell division ATP-binding protein ftsE
LPB136_RS13455	COG0270	DNA (cytosine-5-)-methyltransferase activity
LPB136_RS13475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPB136_RS13570	COG0732	type I restriction modification DNA specificity domain
LPB136_RS13600	COG0535	radical SAM domain protein
LPB136_RS13615	COG3530	Putative quorum-sensing-regulated virulence factor
LPB136_RS13630	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LPB136_RS13635	COG2885	chlorophyll binding
LPB136_RS13635	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LPB136_RS13640	COG2234	aminopeptidase activity
LPB136_RS13645	COG1404	Belongs to the peptidase S8 family