locus-tag	class	description
TEPIRE1_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TEPIRE1_RS00010	COG0592	DNA-directed DNA polymerase activity
TEPIRE1_RS00015	COG2501	S4 domain
TEPIRE1_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TEPIRE1_RS00035	COG0187	DNA topoisomerase II activity
TEPIRE1_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TEPIRE1_RS00045	COG1982	Orn Lys Arg decarboxylase major
TEPIRE1_RS00050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TEPIRE1_RS00055	COG3870	Protein conserved in bacteria
TEPIRE1_RS00060	COG1728	Protein conserved in bacteria
TEPIRE1_RS00070	COG1774	PSP1 C-terminal conserved region
TEPIRE1_RS00075	COG2738	Putative neutral zinc metallopeptidase
TEPIRE1_RS00080	COG3290	protein histidine kinase activity
TEPIRE1_RS00080	COG3829	transcription factor binding
TEPIRE1_RS00090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TEPIRE1_RS00100	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TEPIRE1_RS00105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TEPIRE1_RS00165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TEPIRE1_RS00170	COG2002	toxin-antitoxin pair type II binding
TEPIRE1_RS00185	COG1396	sequence-specific DNA binding
TEPIRE1_RS00190	COG0006	proline dipeptidase activity
TEPIRE1_RS00195	COG4166	transmembrane transport
TEPIRE1_RS00200	COG0601	transmembrane transport
TEPIRE1_RS00205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TEPIRE1_RS00210	COG0444	Belongs to the ABC transporter superfamily
TEPIRE1_RS00215	COG4608	Belongs to the ABC transporter superfamily
TEPIRE1_RS00230	COG1012	belongs to the aldehyde dehydrogenase family
TEPIRE1_RS00245	COG2610	gluconate transmembrane transporter activity
TEPIRE1_RS00260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TEPIRE1_RS00260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TEPIRE1_RS00265	COG2723	6-phospho-beta-galactosidase activity
TEPIRE1_RS00290	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
TEPIRE1_RS00295	COG1473	amidohydrolase
TEPIRE1_RS00300	COG1473	amidohydrolase
TEPIRE1_RS00335	COG1053	succinate dehydrogenase
TEPIRE1_RS00350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TEPIRE1_RS00350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TEPIRE1_RS00365	COG0084	hydrolase, TatD family'
TEPIRE1_RS00375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TEPIRE1_RS00380	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TEPIRE1_RS00395	COG2385	sporulation resulting in formation of a cellular spore
TEPIRE1_RS00400	COG4466	Protein conserved in bacteria
TEPIRE1_RS00410	COG2340	Cysteine-rich secretory protein family
TEPIRE1_RS00425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TEPIRE1_RS00430	COG1802	Transcriptional regulator
TEPIRE1_RS00435	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TEPIRE1_RS00440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TEPIRE1_RS00445	COG2088	sporulation resulting in formation of a cellular spore
TEPIRE1_RS00450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TEPIRE1_RS00455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TEPIRE1_RS00465	COG0193	aminoacyl-tRNA hydrolase activity
TEPIRE1_RS00480	COG2081	HI0933 family
TEPIRE1_RS00485	COG1396	sequence-specific DNA binding
TEPIRE1_RS00500	COG0803	Belongs to the bacterial solute-binding protein 9 family
TEPIRE1_RS00500	COG3443	Belongs to the bacterial solute-binding protein 9 family
TEPIRE1_RS00505	COG1121	(ABC) transporter
TEPIRE1_RS00510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TEPIRE1_RS00515	COG0735	belongs to the Fur family
TEPIRE1_RS00550	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TEPIRE1_RS00570	COG4865	methylaspartate mutase activity
TEPIRE1_RS00595	COG1181	Belongs to the D-alanine--D-alanine ligase family
TEPIRE1_RS00670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TEPIRE1_RS00675	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TEPIRE1_RS00675	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TEPIRE1_RS00680	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TEPIRE1_RS00680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TEPIRE1_RS00715	COG3829	transcription factor binding
TEPIRE1_RS00735	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TEPIRE1_RS00745	COG2183	response to ionizing radiation
TEPIRE1_RS00760	COG0789	Transcriptional regulator
TEPIRE1_RS00765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TEPIRE1_RS00770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TEPIRE1_RS00775	COG0473	3-isopropylmalate dehydrogenase activity
TEPIRE1_RS00780	COG2302	S4 RNA-binding domain
TEPIRE1_RS00800	COG0251	oxidation-reduction process
TEPIRE1_RS00805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TEPIRE1_RS00810	COG0561	phosphatase activity
TEPIRE1_RS00815	COG0534	Mate efflux family protein
TEPIRE1_RS00830	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TEPIRE1_RS00840	COG2002	toxin-antitoxin pair type II binding
TEPIRE1_RS00845	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TEPIRE1_RS00850	COG2244	polysaccharide biosynthetic process
TEPIRE1_RS00855	COG3956	TIGRFAM MazG family protein
TEPIRE1_RS00870	COG2385	sporulation resulting in formation of a cellular spore
TEPIRE1_RS00890	COG1098	S1 RNA binding domain
TEPIRE1_RS00900	COG0085	RNA polymerase activity
TEPIRE1_RS00910	COG1358	cellular component organization or biogenesis
TEPIRE1_RS00915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TEPIRE1_RS00920	COG0049	tRNA binding
TEPIRE1_RS00925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TEPIRE1_RS00930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TEPIRE1_RS00935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TEPIRE1_RS00945	COG0089	rRNA binding
TEPIRE1_RS00950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TEPIRE1_RS00955	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TEPIRE1_RS00960	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TEPIRE1_RS00965	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TEPIRE1_RS00980	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TEPIRE1_RS00985	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TEPIRE1_RS00990	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TEPIRE1_RS01000	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TEPIRE1_RS01005	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TEPIRE1_RS01010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TEPIRE1_RS01015	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TEPIRE1_RS01020	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TEPIRE1_RS01025	COG0200	Binds to the 23S rRNA
TEPIRE1_RS01030	COG0201	protein transport
TEPIRE1_RS01040	COG0024	Methionine aminopeptidase
TEPIRE1_RS01050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TEPIRE1_RS01055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TEPIRE1_RS01065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TEPIRE1_RS01070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TEPIRE1_RS01075	COG0202	RNA polymerase activity
TEPIRE1_RS01080	COG0203	ribosomal protein L17
TEPIRE1_RS01085	COG1122	ATPase activity
TEPIRE1_RS01095	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TEPIRE1_RS01105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TEPIRE1_RS01110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TEPIRE1_RS01115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TEPIRE1_RS01120	COG1160	GTP binding
TEPIRE1_RS01125	COG0534	Mate efflux family protein
TEPIRE1_RS01140	COG0492	ferredoxin-NADP+ reductase activity
TEPIRE1_RS01155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TEPIRE1_RS01160	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TEPIRE1_RS01200	COG0309	Hydrogenase expression formation protein (HypE)
TEPIRE1_RS01215	COG3069	C4-dicarboxylate transmembrane transporter activity
TEPIRE1_RS01230	COG0489	protein tyrosine kinase activity
TEPIRE1_RS01235	COG2894	cell division
TEPIRE1_RS01235	COG2894	cell division
TEPIRE1_RS01240	COG1342	Belongs to the UPF0251 family
TEPIRE1_RS01270	COG1472	Belongs to the glycosyl hydrolase 3 family
TEPIRE1_RS01315	COG1361	Conserved repeat domain
TEPIRE1_RS01345	COG0191	fructose-bisphosphate aldolase activity
TEPIRE1_RS01350	COG1063	alcohol dehydrogenase
TEPIRE1_RS01355	COG3716	PTS system mannose fructose sorbose family IID component
TEPIRE1_RS01360	COG3715	PTS system
TEPIRE1_RS01365	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TEPIRE1_RS01400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TEPIRE1_RS01405	COG4978	Transcriptional regulator
TEPIRE1_RS01405	COG0789	Transcriptional regulator
TEPIRE1_RS01410	COG1238	metal cluster binding
TEPIRE1_RS01435	COG1361	Conserved repeat domain
TEPIRE1_RS01455	COG5012	cobalamin binding
TEPIRE1_RS01470	COG5012	cobalamin binding
TEPIRE1_RS01500	COG5012	cobalamin binding
TEPIRE1_RS01515	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TEPIRE1_RS01520	COG3404	Formiminotransferase-cyclodeaminase
TEPIRE1_RS01525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TEPIRE1_RS01540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TEPIRE1_RS01545	COG0509	glycine decarboxylation via glycine cleavage system
TEPIRE1_RS01550	COG5012	cobalamin binding
TEPIRE1_RS01560	COG2188	Transcriptional regulator
TEPIRE1_RS01565	COG1361	Conserved repeat domain
TEPIRE1_RS01565	COG3266	domain, Protein
TEPIRE1_RS01565	COG2911	Protein conserved in bacteria
TEPIRE1_RS01570	COG1404	Belongs to the peptidase S8 family
TEPIRE1_RS01580	COG5002	protein histidine kinase activity
TEPIRE1_RS01590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TEPIRE1_RS01600	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TEPIRE1_RS01605	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TEPIRE1_RS01620	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TEPIRE1_RS01630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TEPIRE1_RS01635	COG0569	domain protein
TEPIRE1_RS01640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TEPIRE1_RS01650	COG2226	methyltransferase
TEPIRE1_RS01650	COG1073	alpha beta
TEPIRE1_RS01660	COG0747	negative chemotaxis
TEPIRE1_RS01665	COG0601	transmembrane transport
TEPIRE1_RS01670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TEPIRE1_RS01675	COG4172	Belongs to the ABC transporter superfamily
TEPIRE1_RS01695	COG2217	Heavy metal translocating P-type atpase
TEPIRE1_RS01700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TEPIRE1_RS01725	COG0673	inositol 2-dehydrogenase activity
TEPIRE1_RS01730	COG0534	Mate efflux family protein
TEPIRE1_RS01735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TEPIRE1_RS01740	COG0509	glycine decarboxylation via glycine cleavage system
TEPIRE1_RS01745	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TEPIRE1_RS01750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TEPIRE1_RS01765	COG1489	DNA binding
TEPIRE1_RS01785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TEPIRE1_RS01790	COG1773	rubredoxin
TEPIRE1_RS01795	COG1592	Rubrerythrin
TEPIRE1_RS01795	COG1773	rubredoxin
TEPIRE1_RS01825	COG2050	protein possibly involved in aromatic compounds catabolism
TEPIRE1_RS01860	COG3858	chitin binding
TEPIRE1_RS01875	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TEPIRE1_RS01875	COG0493	'glutamate synthase
TEPIRE1_RS01890	COG1924	4 iron, 4 sulfur cluster binding
TEPIRE1_RS01895	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TEPIRE1_RS01900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TEPIRE1_RS01930	COG0768	penicillin binding
TEPIRE1_RS01940	COG0410	ABC transporter
TEPIRE1_RS01970	COG0459	protein refolding
TEPIRE1_RS01990	COG0482	sulfurtransferase activity
TEPIRE1_RS02010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TEPIRE1_RS02015	COG0066	3-isopropylmalate dehydratase activity
TEPIRE1_RS02040	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TEPIRE1_RS02055	COG1053	succinate dehydrogenase
TEPIRE1_RS02095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TEPIRE1_RS02100	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TEPIRE1_RS02105	COG3608	succinylglutamate desuccinylase aspartoacylase
TEPIRE1_RS02105	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TEPIRE1_RS02110	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TEPIRE1_RS02110	COG3608	succinylglutamate desuccinylase aspartoacylase
TEPIRE1_RS02125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TEPIRE1_RS02130	COG1120	ATPase activity
TEPIRE1_RS02135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TEPIRE1_RS02140	COG0709	Synthesizes selenophosphate from selenide and ATP
TEPIRE1_RS02145	COG0425	Belongs to the sulfur carrier protein TusA family
TEPIRE1_RS02150	COG1104	cysteine desulfurase activity
TEPIRE1_RS02180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TEPIRE1_RS02190	COG1063	alcohol dehydrogenase
TEPIRE1_RS02195	COG0626	cystathionine gamma-synthase activity
TEPIRE1_RS02200	COG1070	Carbohydrate kinase
TEPIRE1_RS02205	COG0601	transmembrane transport
TEPIRE1_RS02210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TEPIRE1_RS02220	COG0444	Belongs to the ABC transporter superfamily
TEPIRE1_RS02225	COG4608	Belongs to the ABC transporter superfamily
TEPIRE1_RS02230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TEPIRE1_RS02235	COG3681	Belongs to the UPF0597 family
TEPIRE1_RS02240	COG0310	cobalt ion transport
TEPIRE1_RS02245	COG1122	ATPase activity
TEPIRE1_RS02250	COG1797	cobyrinic acid a,c-diamide synthase activity
TEPIRE1_RS02275	COG2242	protein methyltransferase activity
TEPIRE1_RS02300	COG2099	Precorrin-6x reductase
TEPIRE1_RS02305	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TEPIRE1_RS02310	COG0181	hydroxymethylbilane synthase activity
TEPIRE1_RS02320	COG0113	porphobilinogen synthase activity
TEPIRE1_RS02325	COG1648	precorrin-2 dehydrogenase activity
TEPIRE1_RS02325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TEPIRE1_RS02330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TEPIRE1_RS02335	COG0363	glucosamine-6-phosphate deaminase activity
TEPIRE1_RS02350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TEPIRE1_RS02360	COG4753	response regulator
TEPIRE1_RS02360	COG2207	Transcriptional regulator
TEPIRE1_RS02365	COG2972	Histidine kinase
TEPIRE1_RS02370	COG1129	ABC transporter
TEPIRE1_RS02375	COG1129	ABC transporter
TEPIRE1_RS02380	COG1172	Belongs to the binding-protein-dependent transport system permease family
TEPIRE1_RS02400	COG0071	Belongs to the small heat shock protein (HSP20) family
TEPIRE1_RS02405	COG0736	holo-[acyl-carrier-protein] synthase activity
TEPIRE1_RS02410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TEPIRE1_RS02410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TEPIRE1_RS02415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TEPIRE1_RS02420	COG0864	Transcriptional regulator
TEPIRE1_RS02425	COG2337	Toxic component of a toxin-antitoxin (TA) module
TEPIRE1_RS02430	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TEPIRE1_RS02435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TEPIRE1_RS02440	COG2362	D-Aminopeptidase
TEPIRE1_RS02450	COG0802	atpase or kinase
TEPIRE1_RS02455	COG1214	PFAM Peptidase M22, glycoprotease
TEPIRE1_RS02460	COG0456	acetyltransferase
TEPIRE1_RS02465	COG0110	maltose O-acetyltransferase activity
TEPIRE1_RS02470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TEPIRE1_RS02475	COG0488	(ABC) transporter
TEPIRE1_RS02490	COG0281	malic enzyme
TEPIRE1_RS02510	COG1361	Conserved repeat domain
TEPIRE1_RS02515	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TEPIRE1_RS02520	COG1285	pathogenesis
TEPIRE1_RS02525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TEPIRE1_RS02535	COG2252	PERMEase
TEPIRE1_RS02550	COG1269	ATP hydrolysis coupled proton transport
TEPIRE1_RS02580	COG1394	ATPase activity, coupled to movement of substances
TEPIRE1_RS02625	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TEPIRE1_RS02660	COG0758	DNA mediated transformation
TEPIRE1_RS02700	COG2267	carboxylic ester hydrolase activity
TEPIRE1_RS02720	COG0673	inositol 2-dehydrogenase activity
TEPIRE1_RS02725	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TEPIRE1_RS02730	COG1151	hydroxylamine reductase activity
TEPIRE1_RS02740	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TEPIRE1_RS02750	COG3404	Formiminotransferase-cyclodeaminase
TEPIRE1_RS02765	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TEPIRE1_RS02770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TEPIRE1_RS02775	COG1192	Involved in chromosome partitioning
TEPIRE1_RS02800	COG0509	glycine decarboxylation via glycine cleavage system
TEPIRE1_RS02825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TEPIRE1_RS02830	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TEPIRE1_RS02845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TEPIRE1_RS02850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TEPIRE1_RS02855	COG0446	pyridine nucleotide-disulphide oxidoreductase
TEPIRE1_RS02875	COG2376	Dihydroxyacetone kinase
TEPIRE1_RS02885	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
TEPIRE1_RS02895	COG0432	Pfam Uncharacterised protein family UPF0047
TEPIRE1_RS02905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TEPIRE1_RS02910	COG0561	phosphatase activity
TEPIRE1_RS02915	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TEPIRE1_RS02920	COG2084	Dehydrogenase
TEPIRE1_RS02925	COG0662	Cupin 2, conserved barrel domain protein
TEPIRE1_RS02925	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TEPIRE1_RS02930	COG3835	regulator
TEPIRE1_RS02935	COG3842	ATPase activity
TEPIRE1_RS02945	COG0681	Belongs to the peptidase S26 family
TEPIRE1_RS02970	COG0012	GTP binding
TEPIRE1_RS02985	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TEPIRE1_RS02995	COG0860	N-Acetylmuramoyl-L-alanine amidase
TEPIRE1_RS03000	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
TEPIRE1_RS03010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TEPIRE1_RS03015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TEPIRE1_RS03065	COG0740	serine-type endopeptidase activity
TEPIRE1_RS03070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TEPIRE1_RS03075	COG1067	ATP-dependent peptidase activity
TEPIRE1_RS03075	COG0470	DNA polymerase III
TEPIRE1_RS03080	COG3858	chitin binding
TEPIRE1_RS03080	COG1388	LysM domain
TEPIRE1_RS03090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TEPIRE1_RS03095	COG4496	protein, YerC YecD
TEPIRE1_RS03115	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TEPIRE1_RS03115	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TEPIRE1_RS03125	COG3414	Phosphotransferase system galactitol-specific IIB component
TEPIRE1_RS03130	COG3775	system Galactitol-specific IIC component
TEPIRE1_RS03135	COG1063	alcohol dehydrogenase
TEPIRE1_RS03140	COG1063	alcohol dehydrogenase
TEPIRE1_RS03170	COG0489	protein tyrosine kinase activity
TEPIRE1_RS03220	COG2390	Transcriptional regulator
TEPIRE1_RS03235	COG3732	PTS system glucitol sorbitol-specific
TEPIRE1_RS03250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TEPIRE1_RS03255	COG0022	dehydrogenase e1 component
TEPIRE1_RS03260	COG0508	dehydrogenase complex catalyzes the overall conversion of
TEPIRE1_RS03265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TEPIRE1_RS03270	COG1027	Aspartate ammonia-lyase
TEPIRE1_RS03275	COG0423	glycine-tRNA ligase activity
TEPIRE1_RS03280	COG1609	Transcriptional regulator
TEPIRE1_RS03285	COG1879	ABC-type sugar transport system periplasmic component
TEPIRE1_RS03290	COG1129	ABC transporter
TEPIRE1_RS03295	COG1172	Belongs to the binding-protein-dependent transport system permease family
TEPIRE1_RS03305	COG1402	creatininase
TEPIRE1_RS03310	COG0673	inositol 2-dehydrogenase activity
TEPIRE1_RS03315	COG1082	Xylose isomerase domain protein TIM barrel
TEPIRE1_RS03345	COG0124	histidyl-tRNA synthetase
TEPIRE1_RS03350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TEPIRE1_RS03360	COG0131	Imidazoleglycerol-phosphate dehydratase
TEPIRE1_RS03365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TEPIRE1_RS03370	COG0107	imidazoleglycerol-phosphate synthase activity
TEPIRE1_RS03375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TEPIRE1_RS03375	COG0140	phosphoribosyl-ATP diphosphatase activity
TEPIRE1_RS03420	COG4399	Belongs to the UPF0754 family
TEPIRE1_RS03420	COG4399	Belongs to the UPF0754 family
TEPIRE1_RS03425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TEPIRE1_RS03430	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TEPIRE1_RS03435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TEPIRE1_RS03440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TEPIRE1_RS03445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TEPIRE1_RS03450	COG0569	domain protein
TEPIRE1_RS03455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TEPIRE1_RS03460	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TEPIRE1_RS03465	COG0072	phenylalanine-tRNA ligase activity
TEPIRE1_RS03465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TEPIRE1_RS03470	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TEPIRE1_RS03475	COG1796	DNA polymerase
TEPIRE1_RS03475	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TEPIRE1_RS03480	COG1193	negative regulation of DNA recombination
TEPIRE1_RS03495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TEPIRE1_RS03510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TEPIRE1_RS03515	COG3481	metal-dependent phosphohydrolase, HD sub domain
TEPIRE1_RS03520	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TEPIRE1_RS03525	COG2222	sugar isomerase
TEPIRE1_RS03530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TEPIRE1_RS03545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TEPIRE1_RS03570	COG2239	Acts as a magnesium transporter
TEPIRE1_RS03575	COG2239	Acts as a magnesium transporter
TEPIRE1_RS03580	COG3679	Belongs to the UPF0342 family
TEPIRE1_RS03585	COG1660	Displays ATPase and GTPase activities
TEPIRE1_RS03590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TEPIRE1_RS03595	COG1481	regulation of sporulation
TEPIRE1_RS03600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TEPIRE1_RS03605	COG4109	DRTGG domain
TEPIRE1_RS03620	COG0205	6-phosphofructokinase activity
TEPIRE1_RS03630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TEPIRE1_RS03640	COG1307	EDD domain protein, DegV family
TEPIRE1_RS03660	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TEPIRE1_RS03670	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TEPIRE1_RS03670	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TEPIRE1_RS03680	COG1129	ABC transporter
TEPIRE1_RS03685	COG1172	Belongs to the binding-protein-dependent transport system permease family
TEPIRE1_RS03690	COG0673	inositol 2-dehydrogenase activity
TEPIRE1_RS03695	COG1082	Xylose isomerase domain protein TIM barrel
TEPIRE1_RS03700	COG1940	carbohydrate kinase activity
TEPIRE1_RS03705	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TEPIRE1_RS03735	COG1827	regulation of RNA biosynthetic process
TEPIRE1_RS03755	COG0697	spore germination
TEPIRE1_RS03765	COG0095	Lipoate-protein ligase
TEPIRE1_RS03770	COG1321	iron dependent repressor
TEPIRE1_RS03780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TEPIRE1_RS03785	COG1940	carbohydrate kinase activity
TEPIRE1_RS03790	COG1940	carbohydrate kinase activity
TEPIRE1_RS03800	COG2222	sugar isomerase
TEPIRE1_RS03810	COG1879	ABC-type sugar transport system periplasmic component
TEPIRE1_RS03820	COG4211	Belongs to the binding-protein-dependent transport system permease family
TEPIRE1_RS03830	COG3693	PFAM glycoside hydrolase, family 10
TEPIRE1_RS03845	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TEPIRE1_RS03905	COG0745	RESPONSE REGULATOR receiver
TEPIRE1_RS03910	COG2770	Histidine kinase
TEPIRE1_RS03910	COG2205	protein histidine kinase activity
TEPIRE1_RS03915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TEPIRE1_RS03925	COG2986	histidine ammonia-lyase
TEPIRE1_RS03930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TEPIRE1_RS03935	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TEPIRE1_RS03945	COG1228	amidohydrolase
TEPIRE1_RS03950	COG3404	Formiminotransferase-cyclodeaminase
TEPIRE1_RS03960	COG4166	transmembrane transport
TEPIRE1_RS03965	COG0601	transmembrane transport
TEPIRE1_RS03970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TEPIRE1_RS03975	COG0444	Belongs to the ABC transporter superfamily
TEPIRE1_RS03980	COG4608	Belongs to the ABC transporter superfamily
TEPIRE1_RS04010	COG0438	transferase activity, transferring glycosyl groups
TEPIRE1_RS04050	COG1971	Probably functions as a manganese efflux pump
TEPIRE1_RS04055	COG4191	Histidine kinase
TEPIRE1_RS04060	COG0784	Response regulator, receiver
TEPIRE1_RS04075	COG2358	TRAP transporter, solute receptor (TAXI family
TEPIRE1_RS04080	COG1704	LemA family
TEPIRE1_RS04090	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TEPIRE1_RS04095	COG1278	Cold shock
TEPIRE1_RS04145	COG0653	protein targeting
TEPIRE1_RS04150	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TEPIRE1_RS04155	COG0428	transporter
TEPIRE1_RS04160	COG1040	competence protein
TEPIRE1_RS04180	COG4786	Flagellar basal body rod
TEPIRE1_RS04180	COG1256	bacterial-type flagellum assembly
TEPIRE1_RS04185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TEPIRE1_RS04195	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TEPIRE1_RS04200	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TEPIRE1_RS04230	COG1598	PFAM Uncharacterised protein family UPF0150
TEPIRE1_RS04290	COG0012	GTP binding
TEPIRE1_RS04330	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TEPIRE1_RS04335	COG1516	flagellar protein fliS
TEPIRE1_RS04360	COG1757	Na H antiporter
TEPIRE1_RS04365	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TEPIRE1_RS04375	COG0840	transmembrane signaling receptor activity
TEPIRE1_RS04410	COG1162	GTPase activity
TEPIRE1_RS04490	COG3708	Transcriptional regulator
TEPIRE1_RS04490	COG2207	Transcriptional regulator
TEPIRE1_RS04510	COG3843	relaxase mobilization nuclease domain protein
TEPIRE1_RS04535	COG0745	RESPONSE REGULATOR receiver
TEPIRE1_RS04545	COG1131	(ABC) transporter
TEPIRE1_RS04565	COG0488	(ABC) transporter
TEPIRE1_RS04595	COG3290	protein histidine kinase activity
TEPIRE1_RS04605	COG3279	Response regulator of the LytR AlgR family
TEPIRE1_RS04630	COG3328	transposase activity
TEPIRE1_RS04665	COG0840	transmembrane signaling receptor activity
TEPIRE1_RS04745	COG1396	sequence-specific DNA binding
TEPIRE1_RS04750	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TEPIRE1_RS04770	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TEPIRE1_RS04790	COG0745	RESPONSE REGULATOR receiver
TEPIRE1_RS04795	COG2205	protein histidine kinase activity
TEPIRE1_RS04815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TEPIRE1_RS04820	COG0534	Mate efflux family protein
TEPIRE1_RS04825	COG3584	3D domain protein
TEPIRE1_RS04825	COG3583	domain protein
TEPIRE1_RS04830	COG1686	Belongs to the peptidase S11 family
TEPIRE1_RS04840	COG2323	membrane
TEPIRE1_RS04850	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TEPIRE1_RS04865	COG1111	helicase
TEPIRE1_RS04865	COG1205	dead DEAH box helicase
TEPIRE1_RS04870	COG3359	exonuclease
TEPIRE1_RS04880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TEPIRE1_RS04885	COG0573	inorganic phosphate transmembrane transporter activity
TEPIRE1_RS04890	COG0581	inorganic phosphate transmembrane transporter activity
TEPIRE1_RS04895	COG0745	RESPONSE REGULATOR receiver
TEPIRE1_RS04900	COG5002	protein histidine kinase activity
TEPIRE1_RS04905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TEPIRE1_RS04910	COG0704	Plays a role in the regulation of phosphate uptake
TEPIRE1_RS04915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TEPIRE1_RS04935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TEPIRE1_RS04955	COG1131	(ABC) transporter
TEPIRE1_RS04965	COG1757	Na H antiporter
TEPIRE1_RS04975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TEPIRE1_RS04980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TEPIRE1_RS04995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TEPIRE1_RS05005	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TEPIRE1_RS05010	COG0406	alpha-ribazole phosphatase activity
TEPIRE1_RS05015	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TEPIRE1_RS05035	COG1595	DNA-templated transcription, initiation
TEPIRE1_RS05060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TEPIRE1_RS05065	COG0860	N-Acetylmuramoyl-L-alanine amidase
TEPIRE1_RS05065	COG1388	LysM domain
TEPIRE1_RS05070	COG0557	exoribonuclease II activity
TEPIRE1_RS05090	COG1396	sequence-specific DNA binding
TEPIRE1_RS05130	COG0305	Participates in initiation and elongation during chromosome replication
TEPIRE1_RS05145	COG2052	Domain of unknown function (DUF370)
TEPIRE1_RS05150	COG0629	single-stranded DNA binding
TEPIRE1_RS05190	COG5484	DNA packaging
TEPIRE1_RS05195	COG1783	phage Terminase large subunit
TEPIRE1_RS05300	COG0116	Belongs to the methyltransferase superfamily
TEPIRE1_RS05315	COG0671	phosphoesterase, PA-phosphatase related
TEPIRE1_RS05320	COG0436	Aminotransferase
TEPIRE1_RS05325	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TEPIRE1_RS05330	COG0047	phosphoribosylformylglycinamidine synthase activity
TEPIRE1_RS05335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TEPIRE1_RS05340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TEPIRE1_RS05345	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TEPIRE1_RS05350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TEPIRE1_RS05355	COG0138	bifunctional purine biosynthesis protein purh
TEPIRE1_RS05360	COG0151	Belongs to the GarS family
TEPIRE1_RS05365	COG1592	Rubrerythrin
TEPIRE1_RS05370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TEPIRE1_RS05380	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TEPIRE1_RS05385	COG0658	competence protein
TEPIRE1_RS05385	COG2333	competence protein COMEC
TEPIRE1_RS05390	COG1466	dna polymerase III delta subunit
TEPIRE1_RS05395	COG0268	Binds directly to 16S ribosomal RNA
TEPIRE1_RS05405	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TEPIRE1_RS05420	COG0481	GTPase activity
TEPIRE1_RS05425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TEPIRE1_RS05430	COG1420	regulation of RNA biosynthetic process
TEPIRE1_RS05435	COG0459	protein refolding
TEPIRE1_RS05440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TEPIRE1_RS05450	COG0484	heat shock protein binding
TEPIRE1_RS05455	COG2264	protein methyltransferase activity
TEPIRE1_RS05460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TEPIRE1_RS05465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TEPIRE1_RS05470	COG0537	adenosine 5'-monophosphoramidase activity
TEPIRE1_RS05475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TEPIRE1_RS05480	COG1610	YqeY-like protein
TEPIRE1_RS05485	COG1030	water channel activity
TEPIRE1_RS05510	COG1702	phosphate starvation-inducible protein PhoH
TEPIRE1_RS05515	COG1480	7TM receptor with intracellular HD hydrolase
TEPIRE1_RS05525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TEPIRE1_RS05530	COG1470	cell adhesion involved in biofilm formation
TEPIRE1_RS05535	COG1381	Involved in DNA repair and RecF pathway recombination
TEPIRE1_RS05540	COG0517	IMP dehydrogenase activity
TEPIRE1_RS05545	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TEPIRE1_RS05550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TEPIRE1_RS05550	COG0574	Belongs to the PEP-utilizing enzyme family
TEPIRE1_RS05555	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TEPIRE1_RS05560	COG0358	DNA primase activity
TEPIRE1_RS05565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TEPIRE1_RS05575	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TEPIRE1_RS05585	COG0328	RNA-DNA hybrid ribonuclease activity
TEPIRE1_RS05590	COG2703	oxygen carrier activity
TEPIRE1_RS05605	COG0612	Peptidase, M16
TEPIRE1_RS05610	COG0612	Peptidase, M16
TEPIRE1_RS05615	COG2001	Belongs to the MraZ family
TEPIRE1_RS05620	COG0275	rRNA processing
TEPIRE1_RS05625	COG3116	cell division
TEPIRE1_RS05630	COG0768	penicillin binding
TEPIRE1_RS05640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TEPIRE1_RS05645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TEPIRE1_RS05655	COG0772	Belongs to the SEDS family
TEPIRE1_RS05660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TEPIRE1_RS05665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TEPIRE1_RS05670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TEPIRE1_RS05685	COG3856	small basic protein
TEPIRE1_RS05695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TEPIRE1_RS05705	COG1191	sigma factor activity
TEPIRE1_RS05710	COG1191	sigma factor activity
TEPIRE1_RS05720	COG1873	PFAM PRC-barrel domain
TEPIRE1_RS05725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TEPIRE1_RS05730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TEPIRE1_RS05755	COG1160	GTP binding
TEPIRE1_RS05760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TEPIRE1_RS05765	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TEPIRE1_RS05770	COG1254	Belongs to the acylphosphatase family
TEPIRE1_RS05775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TEPIRE1_RS05780	COG2201	protein-glutamate methylesterase activity
TEPIRE1_RS05785	COG3191	aminopeptidase activity
TEPIRE1_RS05830	COG1739	Uncharacterized protein family UPF0029
TEPIRE1_RS05835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TEPIRE1_RS05840	COG0217	transcriptional regulatory protein
TEPIRE1_RS05850	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TEPIRE1_RS05855	COG0632	four-way junction helicase activity
TEPIRE1_RS05860	COG2255	four-way junction helicase activity
TEPIRE1_RS05865	COG2385	sporulation resulting in formation of a cellular spore
TEPIRE1_RS05870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TEPIRE1_RS05880	COG0343	queuine tRNA-ribosyltransferase activity
TEPIRE1_RS05885	COG1862	Preprotein translocase
TEPIRE1_RS05895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TEPIRE1_RS05900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TEPIRE1_RS05910	COG2030	dehydratase
TEPIRE1_RS05920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TEPIRE1_RS05930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TEPIRE1_RS05935	COG1028	Short-chain dehydrogenase reductase Sdr
TEPIRE1_RS05940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TEPIRE1_RS05945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TEPIRE1_RS05950	COG0571	ribonuclease III activity
TEPIRE1_RS05955	COG2359	stage V sporulation protein S
TEPIRE1_RS05960	COG1196	nuclear chromosome segregation
TEPIRE1_RS05965	COG0552	protein localization to endoplasmic reticulum
TEPIRE1_RS05970	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
TEPIRE1_RS05975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TEPIRE1_RS05980	COG0228	four-way junction DNA binding
TEPIRE1_RS05990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TEPIRE1_RS05995	COG0336	Belongs to the RNA methyltransferase TrmD family
TEPIRE1_RS06000	COG0335	large ribosomal subunit rRNA binding
TEPIRE1_RS06010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TEPIRE1_RS06015	COG0792	nuclease activity
TEPIRE1_RS06020	COG0606	chelatase, subunit chli
TEPIRE1_RS06025	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TEPIRE1_RS06030	COG0758	DNA mediated transformation
TEPIRE1_RS06035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TEPIRE1_RS06040	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TEPIRE1_RS06045	COG4974	Belongs to the 'phage' integrase family
TEPIRE1_RS06050	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TEPIRE1_RS06055	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TEPIRE1_RS06065	COG1815	bacterial-type flagellum-dependent cell motility
TEPIRE1_RS06075	COG1677	Flagellar hook-basal body complex protein FliE
TEPIRE1_RS06080	COG1766	The M ring may be actively involved in energy transduction
TEPIRE1_RS06085	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TEPIRE1_RS06095	COG1157	protein secretion by the type III secretion system
TEPIRE1_RS06115	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TEPIRE1_RS06150	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TEPIRE1_RS06155	COG1776	CheC inhibitor of MCP methylation
TEPIRE1_RS06155	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TEPIRE1_RS06160	COG2201	protein-glutamate methylesterase activity
TEPIRE1_RS06170	COG1338	Plays a role in the flagellum-specific transport system
TEPIRE1_RS06175	COG1987	bacterial-type flagellum assembly
TEPIRE1_RS06180	COG1684	flagellar biosynthetic protein fliR
TEPIRE1_RS06185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TEPIRE1_RS06190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TEPIRE1_RS06195	COG1419	protein localization to endoplasmic reticulum
TEPIRE1_RS06210	COG2198	Histidine kinase
TEPIRE1_RS06210	COG0643	Histidine kinase
TEPIRE1_RS06215	COG0835	chemotaxis
TEPIRE1_RS06220	COG1776	CheC inhibitor of MCP methylation
TEPIRE1_RS06225	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TEPIRE1_RS06230	COG1191	sigma factor activity
TEPIRE1_RS06250	COG0628	permease
TEPIRE1_RS06255	COG0052	Belongs to the universal ribosomal protein uS2 family
TEPIRE1_RS06260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TEPIRE1_RS06265	COG0528	UMP kinase activity
TEPIRE1_RS06270	COG0233	cytoplasmic translational termination
TEPIRE1_RS06280	COG4589	Belongs to the CDS family
TEPIRE1_RS06285	COG0628	permease
TEPIRE1_RS06290	COG0750	zinc metalloprotease
TEPIRE1_RS06295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TEPIRE1_RS06300	COG0442	prolyl-tRNA aminoacylation
TEPIRE1_RS06310	COG2176	DNA-directed DNA polymerase activity
TEPIRE1_RS06315	COG0779	Required for maturation of 30S ribosomal subunits
TEPIRE1_RS06320	COG0195	Participates in both transcription termination and antitermination
TEPIRE1_RS06325	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TEPIRE1_RS06330	COG1358	cellular component organization or biogenesis
TEPIRE1_RS06335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TEPIRE1_RS06340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TEPIRE1_RS06345	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TEPIRE1_RS06350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TEPIRE1_RS06355	COG0196	riboflavin kinase activity
TEPIRE1_RS06360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TEPIRE1_RS06365	COG1185	polyribonucleotide nucleotidyltransferase activity
TEPIRE1_RS06370	COG0726	polysaccharide deacetylase
TEPIRE1_RS06375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TEPIRE1_RS06385	COG1873	PFAM PRC-barrel domain
TEPIRE1_RS06390	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TEPIRE1_RS06395	COG0740	serine-type endopeptidase activity
TEPIRE1_RS06405	COG1674	ftsk spoiiie
TEPIRE1_RS06410	COG1426	Protein conserved in bacteria
TEPIRE1_RS06415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TEPIRE1_RS06425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TEPIRE1_RS06430	COG1546	Belongs to the CinA family
TEPIRE1_RS06430	COG1058	Belongs to the CinA family
TEPIRE1_RS06435	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TEPIRE1_RS06440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TEPIRE1_RS06450	COG1196	nuclear chromosome segregation
TEPIRE1_RS06470	COG1692	metallophosphoesterase
TEPIRE1_RS06475	COG2359	stage V sporulation protein S
TEPIRE1_RS06480	COG0613	PHP domain protein
TEPIRE1_RS06490	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TEPIRE1_RS06490	COG0674	pyruvate-flavodoxin oxidoreductase activity
TEPIRE1_RS06495	COG1013	pyruvate-flavodoxin oxidoreductase activity
TEPIRE1_RS06510	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TEPIRE1_RS06510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TEPIRE1_RS06515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TEPIRE1_RS06515	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TEPIRE1_RS06520	COG1703	isobutyryl-CoA mutase activity
TEPIRE1_RS06525	COG0346	lactoylglutathione lyase activity
TEPIRE1_RS06530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TEPIRE1_RS06540	COG4770	biotin carboxylase activity
TEPIRE1_RS06545	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TEPIRE1_RS06560	COG2720	vancomycin resistance protein
TEPIRE1_RS06575	COG1573	uracil-dna glycosylase
TEPIRE1_RS06580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TEPIRE1_RS06585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TEPIRE1_RS06590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TEPIRE1_RS06595	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TEPIRE1_RS06600	COG1923	regulation of RNA biosynthetic process
TEPIRE1_RS06605	COG0464	growth
TEPIRE1_RS06610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TEPIRE1_RS06625	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TEPIRE1_RS06630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TEPIRE1_RS06650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TEPIRE1_RS06700	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TEPIRE1_RS06705	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TEPIRE1_RS06710	COG1304	FMN binding
TEPIRE1_RS06715	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TEPIRE1_RS06715	COG0539	negative regulation of cytoplasmic translation
TEPIRE1_RS06730	COG2081	HI0933 family
TEPIRE1_RS06740	COG1120	ATPase activity
TEPIRE1_RS06745	COG0010	Belongs to the arginase family
TEPIRE1_RS06760	COG1187	pseudouridine synthase activity
TEPIRE1_RS06775	COG5012	cobalamin binding
TEPIRE1_RS06790	COG0445	tRNA wobble uridine modification
TEPIRE1_RS06795	COG1921	L-seryl-tRNASec selenium transferase activity
TEPIRE1_RS06810	COG3874	Sporulation protein YtfJ
TEPIRE1_RS06820	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TEPIRE1_RS06830	COG0180	Tryptophanyl-tRNA synthetase
TEPIRE1_RS06835	COG1994	Peptidase M50
TEPIRE1_RS06840	COG0019	diaminopimelate decarboxylase activity
TEPIRE1_RS06845	COG1924	4 iron, 4 sulfur cluster binding
TEPIRE1_RS06870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TEPIRE1_RS06880	COG3360	Dodecin
TEPIRE1_RS06885	COG1191	sigma factor activity
TEPIRE1_RS06895	COG1366	Belongs to the anti-sigma-factor antagonist family
TEPIRE1_RS06900	COG1686	Belongs to the peptidase S11 family
TEPIRE1_RS06905	COG4974	Belongs to the 'phage' integrase family
TEPIRE1_RS06910	COG1300	Membrane
TEPIRE1_RS06915	COG1379	DNA repair
TEPIRE1_RS06930	COG0750	zinc metalloprotease
TEPIRE1_RS06935	COG0497	DNA recombination
TEPIRE1_RS06940	COG1438	arginine binding
TEPIRE1_RS06945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TEPIRE1_RS06955	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TEPIRE1_RS06970	COG1722	exodeoxyribonuclease VII activity
TEPIRE1_RS06975	COG1570	exodeoxyribonuclease VII activity
TEPIRE1_RS06980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TEPIRE1_RS06995	COG1302	Protein conserved in bacteria
TEPIRE1_RS07035	COG3854	ATPases associated with a variety of cellular activities
TEPIRE1_RS07045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TEPIRE1_RS07050	COG0006	proline dipeptidase activity
TEPIRE1_RS07090	COG1459	type II secretion system
TEPIRE1_RS07095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TEPIRE1_RS07100	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TEPIRE1_RS07110	COG0768	penicillin binding
TEPIRE1_RS07115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TEPIRE1_RS07130	COG0735	belongs to the Fur family
TEPIRE1_RS07135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TEPIRE1_RS07140	COG3906	Belongs to the UPF0473 family
TEPIRE1_RS07145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TEPIRE1_RS07150	COG0667	Aldo Keto reductase
TEPIRE1_RS07155	COG4472	Bacterial protein of unknown function (DUF965)
TEPIRE1_RS07160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TEPIRE1_RS07170	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TEPIRE1_RS07175	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TEPIRE1_RS07180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TEPIRE1_RS07190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TEPIRE1_RS07195	COG1490	D-aminoacyl-tRNA deacylase activity
TEPIRE1_RS07200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TEPIRE1_RS07205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TEPIRE1_RS07210	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TEPIRE1_RS07210	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TEPIRE1_RS07225	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TEPIRE1_RS07240	COG0280	phosphate acetyltransferase
TEPIRE1_RS07250	COG3480	Lon protease (S16) C-terminal proteolytic domain
TEPIRE1_RS07255	COG3314	Sporulation integral membrane protein YlbJ
TEPIRE1_RS07270	COG0742	ribosomal rna small subunit methyltransferase
TEPIRE1_RS07280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TEPIRE1_RS07285	COG1461	Dihydroxyacetone kinase
TEPIRE1_RS07290	COG1302	Protein conserved in bacteria
TEPIRE1_RS07305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TEPIRE1_RS07310	COG0515	serine threonine protein kinase
TEPIRE1_RS07310	COG2815	serine threonine protein kinase
TEPIRE1_RS07315	COG0631	protein serine/threonine phosphatase activity
TEPIRE1_RS07325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TEPIRE1_RS07325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TEPIRE1_RS07335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TEPIRE1_RS07345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TEPIRE1_RS07350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TEPIRE1_RS07355	COG1758	RNA polymerase activity
TEPIRE1_RS07360	COG0194	GDP metabolic process
TEPIRE1_RS07370	COG1561	YicC-like family, N-terminal region
TEPIRE1_RS07380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TEPIRE1_RS07385	COG0564	pseudouridine synthase activity
TEPIRE1_RS07390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TEPIRE1_RS07405	COG3599	regulation of cell shape
TEPIRE1_RS07415	COG1799	cell septum assembly
TEPIRE1_RS07420	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TEPIRE1_RS07435	COG0083	homoserine kinase activity
TEPIRE1_RS07440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TEPIRE1_RS07445	COG0460	homoserine dehydrogenase
TEPIRE1_RS07450	COG4492	Belongs to the UPF0735 family
TEPIRE1_RS07455	COG4347	Protein of unknown function (DUF1405)
TEPIRE1_RS07460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TEPIRE1_RS07465	COG3409	Peptidoglycan-binding domain 1 protein
TEPIRE1_RS07465	COG0793	Belongs to the peptidase S41A family
TEPIRE1_RS07470	COG2070	2-Nitropropane dioxygenase
TEPIRE1_RS07480	COG1136	(ABC) transporter
TEPIRE1_RS07490	COG1136	(ABC) transporter
TEPIRE1_RS07490	COG0577	efflux transmembrane transporter activity
TEPIRE1_RS07505	COG0525	valine-tRNA ligase activity
TEPIRE1_RS07520	COG1555	photosystem II stabilization
TEPIRE1_RS07530	COG0719	Fe-S assembly protein
TEPIRE1_RS07535	COG1137	ATPase activity
TEPIRE1_RS07540	COG0495	leucyl-tRNA aminoacylation
TEPIRE1_RS07550	COG1316	TRANSCRIPTIONal
TEPIRE1_RS07555	COG1713	HD superfamily hydrolase involved in NAD metabolism
TEPIRE1_RS07560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TEPIRE1_RS07565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TEPIRE1_RS07575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TEPIRE1_RS07580	COG2868	ribosomal protein
TEPIRE1_RS07585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TEPIRE1_RS07595	COG2959	enzyme of heme biosynthesis
TEPIRE1_RS07620	COG1530	ribonuclease E activity
TEPIRE1_RS07645	COG0772	Belongs to the SEDS family
TEPIRE1_RS07655	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TEPIRE1_RS07660	COG2894	cell division
TEPIRE1_RS07665	COG0850	regulation of cytokinetic process
TEPIRE1_RS07670	COG0768	penicillin binding
TEPIRE1_RS07685	COG1077	Cell shape determining protein MreB Mrl
TEPIRE1_RS07690	COG2003	Belongs to the UPF0758 family
TEPIRE1_RS07695	COG0424	maF-like protein
TEPIRE1_RS07715	COG1595	DNA-templated transcription, initiation
TEPIRE1_RS07740	COG1063	alcohol dehydrogenase
TEPIRE1_RS07760	COG1063	alcohol dehydrogenase
TEPIRE1_RS07775	COG3290	protein histidine kinase activity
TEPIRE1_RS07775	COG3829	transcription factor binding
TEPIRE1_RS07790	COG0840	transmembrane signaling receptor activity
TEPIRE1_RS07795	COG0700	Nucleoside recognition
TEPIRE1_RS07800	COG2715	membrane protein required for spore maturation
TEPIRE1_RS07805	COG0322	excinuclease ABC activity
TEPIRE1_RS07815	COG0686	Belongs to the AlaDH PNT family
TEPIRE1_RS07825	COG5002	protein histidine kinase activity
TEPIRE1_RS07830	COG0745	RESPONSE REGULATOR receiver
TEPIRE1_RS07850	COG1283	sodium-dependent phosphate transmembrane transporter activity
TEPIRE1_RS07855	COG1283	sodium-dependent phosphate transmembrane transporter activity
TEPIRE1_RS07875	COG4120	Belongs to the binding-protein-dependent transport system permease family
TEPIRE1_RS07880	COG3842	ATPase activity
TEPIRE1_RS07885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TEPIRE1_RS07895	COG2721	sulfolactate sulfo-lyase activity
TEPIRE1_RS07900	COG0246	Mannitol dehydrogenase
TEPIRE1_RS07905	COG3718	enzyme involved in inositol metabolism
TEPIRE1_RS07925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TEPIRE1_RS07955	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TEPIRE1_RS07970	COG0301	tRNA thio-modification
TEPIRE1_RS07985	COG5577	PFAM Coat F domain
TEPIRE1_RS08020	COG0747	negative chemotaxis
TEPIRE1_RS08030	COG2707	UPF0756 membrane protein
TEPIRE1_RS08035	COG0741	lytic transglycosylase activity
TEPIRE1_RS08040	COG0237	dephospho-CoA kinase activity
TEPIRE1_RS08050	COG5662	AntiSigma factor
TEPIRE1_RS08055	COG1595	DNA-templated transcription, initiation
TEPIRE1_RS08075	COG0559	Belongs to the binding-protein-dependent transport system permease family
TEPIRE1_RS08090	COG0428	transporter
TEPIRE1_RS08095	COG0159	tryptophan synthase activity
TEPIRE1_RS08100	COG0133	tryptophan synthase activity
TEPIRE1_RS08115	COG0134	indole-3-glycerol-phosphate synthase activity
TEPIRE1_RS08125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TEPIRE1_RS08125	COG0512	Glutamine amidotransferase of anthranilate synthase
TEPIRE1_RS08130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TEPIRE1_RS08135	COG2723	6-phospho-beta-galactosidase activity
TEPIRE1_RS08140	COG2059	Chromate
TEPIRE1_RS08145	COG2059	Chromate
TEPIRE1_RS08150	COG1940	carbohydrate kinase activity
TEPIRE1_RS08155	COG0641	radical SAM
TEPIRE1_RS08160	COG3408	Glycogen debranching enzyme
TEPIRE1_RS08160	COG3119	arylsulfatase activity
TEPIRE1_RS08165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TEPIRE1_RS08175	COG1447	Phosphotransferase system cellobiose-specific component IIA
TEPIRE1_RS08190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TEPIRE1_RS08200	COG1447	Phosphotransferase system cellobiose-specific component IIA
TEPIRE1_RS08205	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TEPIRE1_RS08205	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TEPIRE1_RS08210	COG0840	transmembrane signaling receptor activity
TEPIRE1_RS08215	COG3773	Cell wall hydrolase
TEPIRE1_RS08215	COG3409	Peptidoglycan-binding domain 1 protein
TEPIRE1_RS08220	COG0546	phosphoglycolate phosphatase activity
TEPIRE1_RS08225	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TEPIRE1_RS08250	COG0556	nucleotide-excision repair
TEPIRE1_RS08260	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TEPIRE1_RS08265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TEPIRE1_RS08270	COG0793	Belongs to the peptidase S41A family
TEPIRE1_RS08275	COG1196	nuclear chromosome segregation
TEPIRE1_RS08275	COG0739	heme binding
TEPIRE1_RS08275	COG0741	lytic transglycosylase activity
TEPIRE1_RS08280	COG2177	Part of the ABC transporter FtsEX involved in
TEPIRE1_RS08285	COG2884	Cell division ATP-binding protein ftsE
TEPIRE1_RS08290	COG0733	neurotransmitter:sodium symporter activity
TEPIRE1_RS08295	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TEPIRE1_RS08335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TEPIRE1_RS08340	COG3959	Transketolase, thiamine diphosphate binding domain
TEPIRE1_RS08345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TEPIRE1_RS08360	COG0438	transferase activity, transferring glycosyl groups
TEPIRE1_RS08375	COG0297	glycogen (starch) synthase activity
TEPIRE1_RS08390	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TEPIRE1_RS08400	COG0363	glucosamine-6-phosphate deaminase activity
TEPIRE1_RS08405	COG0191	fructose-bisphosphate aldolase activity
TEPIRE1_RS08415	COG1376	ErfK ybiS ycfS ynhG family protein
TEPIRE1_RS08420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TEPIRE1_RS08425	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TEPIRE1_RS08430	COG1691	(AIR) carboxylase
TEPIRE1_RS08435	COG1606	tRNA processing
TEPIRE1_RS08440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TEPIRE1_RS08445	COG3858	chitin binding
TEPIRE1_RS08460	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TEPIRE1_RS08465	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TEPIRE1_RS08470	COG3716	PTS system mannose fructose sorbose family IID component
TEPIRE1_RS08475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TEPIRE1_RS08485	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TEPIRE1_RS08490	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TEPIRE1_RS08490	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TEPIRE1_RS08495	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TEPIRE1_RS08495	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TEPIRE1_RS08510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TEPIRE1_RS08525	COG1980	fructose-bisphosphate aldolase activity
TEPIRE1_RS08545	COG2184	nucleotidyltransferase activity
TEPIRE1_RS08565	COG0519	Catalyzes the synthesis of GMP from XMP
TEPIRE1_RS08565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TEPIRE1_RS08570	COG0577	efflux transmembrane transporter activity
TEPIRE1_RS08575	COG1136	(ABC) transporter
TEPIRE1_RS08580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TEPIRE1_RS08590	COG1131	(ABC) transporter
TEPIRE1_RS08595	COG1725	Transcriptional regulator
TEPIRE1_RS08600	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TEPIRE1_RS08605	COG0456	acetyltransferase
TEPIRE1_RS08620	COG3715	PTS system
TEPIRE1_RS08635	COG1737	Transcriptional regulator
TEPIRE1_RS08655	COG3829	transcription factor binding
TEPIRE1_RS08655	COG3290	protein histidine kinase activity
TEPIRE1_RS08660	COG2190	(PTS) system
TEPIRE1_RS08660	COG1263	PTS System
TEPIRE1_RS08660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TEPIRE1_RS08665	COG3711	transcriptional antiterminator
TEPIRE1_RS08670	COG1263	PTS System
TEPIRE1_RS08670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TEPIRE1_RS08670	COG2190	(PTS) system
TEPIRE1_RS08675	COG1802	Transcriptional regulator
TEPIRE1_RS08680	COG3718	enzyme involved in inositol metabolism
TEPIRE1_RS08690	COG1063	alcohol dehydrogenase
TEPIRE1_RS08695	COG0673	inositol 2-dehydrogenase activity
TEPIRE1_RS08725	COG1028	Short-chain dehydrogenase reductase Sdr
TEPIRE1_RS08730	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TEPIRE1_RS08740	COG1070	Carbohydrate kinase
TEPIRE1_RS08745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TEPIRE1_RS08750	COG0246	Mannitol dehydrogenase
TEPIRE1_RS08755	COG3447	MASE1 domain protein
TEPIRE1_RS08755	COG5001	Diguanylate cyclase
TEPIRE1_RS08755	COG5002	protein histidine kinase activity
TEPIRE1_RS08770	COG0728	peptidoglycan biosynthetic process
TEPIRE1_RS08800	COG0438	transferase activity, transferring glycosyl groups
TEPIRE1_RS08830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TEPIRE1_RS08835	COG0736	holo-[acyl-carrier-protein] synthase activity
TEPIRE1_RS08850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TEPIRE1_RS08860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TEPIRE1_RS08865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TEPIRE1_RS08905	COG0542	response to heat
TEPIRE1_RS08910	COG1803	Methylglyoxal synthase
TEPIRE1_RS08920	COG0577	efflux transmembrane transporter activity
TEPIRE1_RS08920	COG1136	(ABC) transporter
TEPIRE1_RS08925	COG1136	(ABC) transporter
TEPIRE1_RS08935	COG0585	pseudouridine synthase activity
TEPIRE1_RS08950	COG0726	polysaccharide deacetylase
TEPIRE1_RS08955	COG1187	pseudouridine synthase activity
TEPIRE1_RS08970	COG1028	Short-chain dehydrogenase reductase Sdr
TEPIRE1_RS08990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TEPIRE1_RS08995	COG0281	malic enzyme
TEPIRE1_RS09005	COG0179	Fumarylacetoacetate (FAA) hydrolase
TEPIRE1_RS09010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TEPIRE1_RS09015	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TEPIRE1_RS09045	COG1609	Transcriptional regulator
TEPIRE1_RS09055	COG0745	RESPONSE REGULATOR receiver
TEPIRE1_RS09070	COG0577	efflux transmembrane transporter activity
TEPIRE1_RS09070	COG1136	(ABC) transporter
TEPIRE1_RS09080	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TEPIRE1_RS09085	COG1063	alcohol dehydrogenase
TEPIRE1_RS09095	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TEPIRE1_RS09100	COG1024	Enoyl-CoA hydratase
TEPIRE1_RS09110	COG2030	dehydratase
TEPIRE1_RS09115	COG1082	Xylose isomerase domain protein TIM barrel
TEPIRE1_RS09125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TEPIRE1_RS09130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TEPIRE1_RS09135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TEPIRE1_RS09150	COG0800	Aldolase
TEPIRE1_RS09160	COG4211	Belongs to the binding-protein-dependent transport system permease family
TEPIRE1_RS09170	COG1879	ABC-type sugar transport system periplasmic component
TEPIRE1_RS09175	COG4213	ABC transporter substrate-binding protein
TEPIRE1_RS09180	COG2197	response regulator
TEPIRE1_RS09185	COG3275	phosphorelay sensor kinase activity
TEPIRE1_RS09205	COG0840	transmembrane signaling receptor activity
TEPIRE1_RS09215	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TEPIRE1_RS09220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TEPIRE1_RS09220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TEPIRE1_RS09230	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TEPIRE1_RS09230	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TEPIRE1_RS09245	COG3732	PTS system glucitol sorbitol-specific
TEPIRE1_RS09260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TEPIRE1_RS09270	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TEPIRE1_RS09285	COG3829	transcription factor binding
TEPIRE1_RS09290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TEPIRE1_RS09300	COG1447	Phosphotransferase system cellobiose-specific component IIA
TEPIRE1_RS09310	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TEPIRE1_RS09310	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TEPIRE1_RS09350	COG1757	Na H antiporter
TEPIRE1_RS09355	COG3033	Beta-eliminating lyase
TEPIRE1_RS09370	COG3546	catalase activity
TEPIRE1_RS09375	COG2878	Part of a membrane complex involved in electron transport
TEPIRE1_RS09375	COG1245	4Fe-4S binding domain
TEPIRE1_RS09380	COG4657	Part of a membrane complex involved in electron transport
TEPIRE1_RS09385	COG4660	Part of a membrane complex involved in electron transport
TEPIRE1_RS09390	COG4659	FMN binding
TEPIRE1_RS09395	COG4658	electron transport chain
TEPIRE1_RS09400	COG4656	Part of a membrane complex involved in electron transport
TEPIRE1_RS09405	COG2116	formate transmembrane transporter activity
TEPIRE1_RS09425	COG4191	Histidine kinase
TEPIRE1_RS09450	COG2172	sigma factor antagonist activity
TEPIRE1_RS09455	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TEPIRE1_RS09470	COG4608	Belongs to the ABC transporter superfamily
TEPIRE1_RS09475	COG0444	Belongs to the ABC transporter superfamily
TEPIRE1_RS09480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TEPIRE1_RS09485	COG0601	transmembrane transport
TEPIRE1_RS09490	COG0747	negative chemotaxis
TEPIRE1_RS09495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TEPIRE1_RS09500	COG0154	amidase activity
TEPIRE1_RS09505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TEPIRE1_RS09525	COG1725	Transcriptional regulator
TEPIRE1_RS09540	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TEPIRE1_RS09540	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TEPIRE1_RS09555	COG1217	gtp-binding protein TYPA
TEPIRE1_RS09570	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TEPIRE1_RS09575	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TEPIRE1_RS09590	COG1301	dicarboxylic acid transport
TEPIRE1_RS09595	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TEPIRE1_RS09600	COG0402	S-adenosylhomocysteine deaminase activity
TEPIRE1_RS09625	COG1215	transferase activity, transferring glycosyl groups
TEPIRE1_RS09640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TEPIRE1_RS09645	COG0028	Belongs to the TPP enzyme family
TEPIRE1_RS09650	COG0473	3-isopropylmalate dehydrogenase activity
TEPIRE1_RS09655	COG0066	3-isopropylmalate dehydratase activity
TEPIRE1_RS09660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TEPIRE1_RS09665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TEPIRE1_RS09670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TEPIRE1_RS09675	COG0440	acetolactate synthase activity
TEPIRE1_RS09680	COG0028	Belongs to the TPP enzyme family
TEPIRE1_RS09705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TEPIRE1_RS09710	COG1473	amidohydrolase
TEPIRE1_RS09715	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TEPIRE1_RS09725	COG0129	dihydroxy-acid dehydratase activity
TEPIRE1_RS09730	COG1250	3-hydroxyacyl-CoA dehydrogenase
TEPIRE1_RS09735	COG2186	Transcriptional regulator
TEPIRE1_RS09740	COG3958	Transketolase
TEPIRE1_RS09745	COG3959	Transketolase, thiamine diphosphate binding domain
TEPIRE1_RS09755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TEPIRE1_RS09755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TEPIRE1_RS09765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TEPIRE1_RS09790	COG2972	Histidine kinase
TEPIRE1_RS09795	COG1126	abc transporter atp-binding protein
TEPIRE1_RS09800	COG0765	amino acid transport
TEPIRE1_RS09805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TEPIRE1_RS09810	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TEPIRE1_RS09815	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TEPIRE1_RS09820	COG1074	ATP-dependent DNA helicase activity
TEPIRE1_RS09830	COG0148	phosphopyruvate hydratase activity
TEPIRE1_RS09840	COG0149	triose-phosphate isomerase activity
TEPIRE1_RS09845	COG0126	phosphoglycerate kinase activity
TEPIRE1_RS09850	COG2390	Transcriptional regulator
TEPIRE1_RS09860	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TEPIRE1_RS09880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TEPIRE1_RS09885	COG0527	aspartate kinase activity
TEPIRE1_RS09890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TEPIRE1_RS09895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TEPIRE1_RS09910	COG1013	pyruvate-flavodoxin oxidoreductase activity
TEPIRE1_RS09910	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TEPIRE1_RS09910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TEPIRE1_RS09910	COG0674	pyruvate-flavodoxin oxidoreductase activity
TEPIRE1_RS09915	COG1307	EDD domain protein, DegV family
TEPIRE1_RS09925	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TEPIRE1_RS09935	COG0295	cytidine deaminase activity
TEPIRE1_RS09940	COG2188	Transcriptional regulator
TEPIRE1_RS09950	COG1079	Belongs to the binding-protein-dependent transport system permease family
TEPIRE1_RS09955	COG4603	Belongs to the binding-protein-dependent transport system permease family
TEPIRE1_RS09960	COG3845	ABC transporter
TEPIRE1_RS09965	COG1744	ABC transporter substrate-binding protein PnrA-like
TEPIRE1_RS09970	COG0673	inositol 2-dehydrogenase activity
TEPIRE1_RS09985	COG3290	protein histidine kinase activity
TEPIRE1_RS09995	COG3279	Response regulator of the LytR AlgR family
TEPIRE1_RS10015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TEPIRE1_RS10020	COG4279	zinc finger
TEPIRE1_RS10030	COG4821	SIS domain
TEPIRE1_RS10045	COG3037	sugar-specific permease SgaT UlaA
TEPIRE1_RS10055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TEPIRE1_RS10060	COG3875	lactate racemase activity
TEPIRE1_RS10075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TEPIRE1_RS10080	COG0693	protein deglycase activity
TEPIRE1_RS10090	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TEPIRE1_RS10095	COG3457	Alanine racemase
TEPIRE1_RS10100	COG0626	cystathionine gamma-synthase activity
TEPIRE1_RS10105	COG1735	metal-dependent hydrolase with the TIM-barrel fold
TEPIRE1_RS10120	COG3711	transcriptional antiterminator
TEPIRE1_RS10125	COG2188	Transcriptional regulator
TEPIRE1_RS10130	COG0561	phosphatase activity
TEPIRE1_RS10160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TEPIRE1_RS10165	COG1757	Na H antiporter
TEPIRE1_RS10170	COG5002	protein histidine kinase activity
TEPIRE1_RS10170	COG3850	Histidine kinase
TEPIRE1_RS10175	COG0745	RESPONSE REGULATOR receiver
TEPIRE1_RS10205	COG0346	lactoylglutathione lyase activity
TEPIRE1_RS10210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TEPIRE1_RS10215	COG1070	Carbohydrate kinase
TEPIRE1_RS10220	COG0667	Aldo Keto reductase
TEPIRE1_RS10225	COG1172	Belongs to the binding-protein-dependent transport system permease family
TEPIRE1_RS10230	COG1129	ABC transporter
TEPIRE1_RS10235	COG1879	ABC-type sugar transport system periplasmic component
TEPIRE1_RS10250	COG0306	phosphate transporter
TEPIRE1_RS10255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TEPIRE1_RS10275	COG5416	Lipopolysaccharide assembly protein A domain
TEPIRE1_RS10280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TEPIRE1_RS10295	COG4786	Flagellar basal body rod
TEPIRE1_RS10300	COG1077	Cell shape determining protein MreB Mrl
TEPIRE1_RS10305	COG1609	Transcriptional regulator
TEPIRE1_RS10315	COG2385	sporulation resulting in formation of a cellular spore
TEPIRE1_RS10320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TEPIRE1_RS10345	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TEPIRE1_RS10350	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TEPIRE1_RS10365	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TEPIRE1_RS10370	COG1269	ATP hydrolysis coupled proton transport
TEPIRE1_RS10390	COG4447	cellulose binding
TEPIRE1_RS10395	COG1191	sigma factor activity
TEPIRE1_RS10400	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TEPIRE1_RS10405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TEPIRE1_RS10415	COG3959	Transketolase, thiamine diphosphate binding domain
TEPIRE1_RS10430	COG1653	transport
TEPIRE1_RS10435	COG2186	Transcriptional regulator
TEPIRE1_RS10455	COG2131	deaminase
TEPIRE1_RS10470	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
TEPIRE1_RS10480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TEPIRE1_RS10490	COG0673	inositol 2-dehydrogenase activity
TEPIRE1_RS10500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TEPIRE1_RS10505	COG0698	ribose 5-phosphate isomerase
TEPIRE1_RS10515	COG0009	L-threonylcarbamoyladenylate synthase
TEPIRE1_RS10525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TEPIRE1_RS10530	COG3872	metal-dependent enzyme
TEPIRE1_RS10535	COG0254	rRNA binding
TEPIRE1_RS10545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TEPIRE1_RS10555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TEPIRE1_RS10565	COG3885	ferrous iron binding
TEPIRE1_RS10565	COG2078	PFAM AMMECR1 domain protein
TEPIRE1_RS10575	COG5322	oxidoreductase activity
TEPIRE1_RS10575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TEPIRE1_RS10595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TEPIRE1_RS10620	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TEPIRE1_RS10630	COG3835	regulator
TEPIRE1_RS10635	COG0840	transmembrane signaling receptor activity
TEPIRE1_RS10650	COG1929	Belongs to the glycerate kinase type-1 family
TEPIRE1_RS10655	COG1070	Carbohydrate kinase
TEPIRE1_RS10660	COG2610	gluconate transmembrane transporter activity
TEPIRE1_RS10670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TEPIRE1_RS10675	COG1737	Transcriptional regulator
TEPIRE1_RS10680	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TEPIRE1_RS10685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TEPIRE1_RS10690	COG1028	Short-chain dehydrogenase reductase Sdr
TEPIRE1_RS10695	COG0037	tRNA processing
TEPIRE1_RS10735	COG0463	Glycosyl transferase, family 2
TEPIRE1_RS10740	COG0071	Belongs to the small heat shock protein (HSP20) family
TEPIRE1_RS10745	COG0222	ribosome binding
TEPIRE1_RS10750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TEPIRE1_RS10765	COG0250	Participates in transcription elongation, termination and antitermination
TEPIRE1_RS10770	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TEPIRE1_RS10775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TEPIRE1_RS10785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TEPIRE1_RS10815	COG3688	RNA-binding protein containing a PIN domain
TEPIRE1_RS10820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TEPIRE1_RS10830	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
TEPIRE1_RS10840	COG1045	serine acetyltransferase
TEPIRE1_RS10845	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TEPIRE1_RS10850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TEPIRE1_RS10855	COG4956	integral membrane protein (PIN domain superfamily)
TEPIRE1_RS10860	COG1329	Transcriptional regulator
TEPIRE1_RS10870	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TEPIRE1_RS10875	COG0542	response to heat
TEPIRE1_RS10880	COG3869	Catalyzes the specific phosphorylation of arginine residues in
TEPIRE1_RS10885	COG3880	PFAM UvrB UvrC protein
TEPIRE1_RS10900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TEPIRE1_RS10905	COG0516	GMP reductase activity
TEPIRE1_RS10905	COG0517	IMP dehydrogenase activity
TEPIRE1_RS10915	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TEPIRE1_RS10915	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TEPIRE1_RS10920	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TEPIRE1_RS10925	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TEPIRE1_RS10940	COG1486	melibiose metabolic process
TEPIRE1_RS10945	COG1435	thymidine kinase activity
TEPIRE1_RS10965	COG1752	Esterase of the alpha-beta hydrolase superfamily
TEPIRE1_RS10970	COG1013	pyruvate-flavodoxin oxidoreductase activity
TEPIRE1_RS10975	COG0674	pyruvate-flavodoxin oxidoreductase activity
TEPIRE1_RS10980	COG1144	Oxidoreductase
TEPIRE1_RS10985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TEPIRE1_RS11020	COG1850	ribulose-bisphosphate carboxylase activity
TEPIRE1_RS11030	COG1070	Carbohydrate kinase
TEPIRE1_RS11035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TEPIRE1_RS11045	COG0446	pyridine nucleotide-disulphide oxidoreductase
TEPIRE1_RS11050	COG0579	oxidoreductase
TEPIRE1_RS11060	COG0698	ribose 5-phosphate isomerase
TEPIRE1_RS11065	COG1349	DNA-binding transcription factor activity
TEPIRE1_RS11070	COG1461	Dihydroxyacetone kinase
TEPIRE1_RS11075	COG2376	Dihydroxyacetone kinase
TEPIRE1_RS11080	COG0517	IMP dehydrogenase activity
TEPIRE1_RS11080	COG0516	GMP reductase activity
TEPIRE1_RS11095	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TEPIRE1_RS11100	COG2814	Major facilitator Superfamily
TEPIRE1_RS11105	COG3426	butyrate kinase activity
TEPIRE1_RS11110	COG0280	phosphate acetyltransferase
TEPIRE1_RS11145	COG0655	NAD(P)H dehydrogenase (quinone) activity
TEPIRE1_RS11160	COG1131	(ABC) transporter
TEPIRE1_RS11165	COG0640	Transcriptional regulator
TEPIRE1_RS11185	COG1447	Phosphotransferase system cellobiose-specific component IIA
TEPIRE1_RS11190	COG1446	asparaginase
TEPIRE1_RS11195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TEPIRE1_RS11205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TEPIRE1_RS11220	COG3711	transcriptional antiterminator
TEPIRE1_RS11225	COG0720	synthase
TEPIRE1_RS11230	COG1469	GTP cyclohydrolase I activity
TEPIRE1_RS11235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TEPIRE1_RS11240	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TEPIRE1_RS11240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TEPIRE1_RS11245	COG2723	6-phospho-beta-galactosidase activity
TEPIRE1_RS11250	COG0446	pyridine nucleotide-disulphide oxidoreductase
TEPIRE1_RS11250	COG1902	pentaerythritol trinitrate reductase activity
TEPIRE1_RS11255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TEPIRE1_RS11270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TEPIRE1_RS11270	COG3711	transcriptional antiterminator
TEPIRE1_RS11325	COG3875	lactate racemase activity
TEPIRE1_RS11340	COG3052	prosthetic group binding
TEPIRE1_RS11350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TEPIRE1_RS11355	COG0473	3-isopropylmalate dehydrogenase activity
TEPIRE1_RS11365	COG2828	Protein conserved in bacteria
TEPIRE1_RS11375	COG0583	DNA-binding transcription factor activity
TEPIRE1_RS11410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TEPIRE1_RS11425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TEPIRE1_RS11430	COG2610	gluconate transmembrane transporter activity
TEPIRE1_RS11435	COG3290	protein histidine kinase activity
TEPIRE1_RS11435	COG3829	transcription factor binding
TEPIRE1_RS11625	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TEPIRE1_RS11630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TEPIRE1_RS11645	COG0590	tRNA wobble adenosine to inosine editing
TEPIRE1_RS11670	COG1247	-acetyltransferase
TEPIRE1_RS11680	COG1550	Protein conserved in bacteria
TEPIRE1_RS11685	COG0765	amino acid transport
TEPIRE1_RS11695	COG0765	amino acid transport
TEPIRE1_RS11700	COG2423	ornithine cyclodeaminase activity
TEPIRE1_RS11715	COG0733	neurotransmitter:sodium symporter activity
TEPIRE1_RS11720	COG3033	Beta-eliminating lyase
TEPIRE1_RS11725	COG3829	transcription factor binding
TEPIRE1_RS11725	COG3290	protein histidine kinase activity
TEPIRE1_RS11750	COG2186	Transcriptional regulator
TEPIRE1_RS11755	COG1620	l-lactate permease
TEPIRE1_RS11760	COG2086	electron transfer activity
TEPIRE1_RS11765	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TEPIRE1_RS11770	COG0277	FAD linked oxidase domain protein
TEPIRE1_RS11785	COG1595	DNA-templated transcription, initiation
TEPIRE1_RS11795	COG4176	ABC-type proline glycine betaine transport system permease component
TEPIRE1_RS11810	COG0726	polysaccharide deacetylase
TEPIRE1_RS11815	COG0531	amino acid
TEPIRE1_RS11820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TEPIRE1_RS11830	COG1917	Cupin 2, conserved barrel domain protein
TEPIRE1_RS11830	COG1396	sequence-specific DNA binding
TEPIRE1_RS11840	COG0840	transmembrane signaling receptor activity
TEPIRE1_RS11940	COG3077	Addiction module antitoxin, RelB DinJ family
TEPIRE1_RS11995	COG5464	transposase or invertase
TEPIRE1_RS12005	COG4974	Belongs to the 'phage' integrase family
TEPIRE1_RS12010	COG0860	N-Acetylmuramoyl-L-alanine amidase
TEPIRE1_RS12015	COG4824	toxin secretion phage lysis holin
TEPIRE1_RS12095	COG0740	serine-type endopeptidase activity
TEPIRE1_RS12105	COG4626	Terminase
TEPIRE1_RS12105	COG1802	Transcriptional regulator
TEPIRE1_RS12140	COG3077	Addiction module antitoxin, RelB DinJ family
TEPIRE1_RS12145	COG3041	Addiction module toxin RelE StbE family
TEPIRE1_RS12185	COG4133	protoheme IX ABC transporter activity
TEPIRE1_RS12205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TEPIRE1_RS12205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TEPIRE1_RS12265	COG1067	ATP-dependent peptidase activity
TEPIRE1_RS12270	COG2348	transferase activity, transferring amino-acyl groups
TEPIRE1_RS12280	COG0504	CTP synthase activity
TEPIRE1_RS12285	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TEPIRE1_RS12290	COG0018	arginyl-trna synthetase
TEPIRE1_RS12300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TEPIRE1_RS12305	COG0284	orotidine-5'-phosphate decarboxylase activity
TEPIRE1_RS12310	COG0167	dihydroorotate dehydrogenase activity
TEPIRE1_RS12315	COG0543	2 iron, 2 sulfur cluster binding
TEPIRE1_RS12325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TEPIRE1_RS12330	COG0540	Belongs to the ATCase OTCase family
TEPIRE1_RS12340	COG1605	Chorismate mutase
TEPIRE1_RS12340	COG0077	Prephenate dehydratase
TEPIRE1_RS12345	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TEPIRE1_RS12350	COG0287	Prephenate dehydrogenase
TEPIRE1_RS12355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TEPIRE1_RS12360	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TEPIRE1_RS12365	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TEPIRE1_RS12375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TEPIRE1_RS12380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TEPIRE1_RS12385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TEPIRE1_RS12390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TEPIRE1_RS12400	COG3409	Peptidoglycan-binding domain 1 protein
TEPIRE1_RS12400	COG3773	Cell wall hydrolase
TEPIRE1_RS12410	COG1982	Orn Lys Arg decarboxylase major
TEPIRE1_RS12470	COG2059	Chromate
TEPIRE1_RS12475	COG2059	Chromate
TEPIRE1_RS12480	COG1115	amino acid carrier protein
TEPIRE1_RS12505	COG0534	Mate efflux family protein
TEPIRE1_RS12510	COG1917	Cupin 2, conserved barrel domain protein
TEPIRE1_RS12510	COG2207	Transcriptional regulator
TEPIRE1_RS12525	COG0514	ATP-dependent DNA helicase (RecQ)
TEPIRE1_RS12545	COG1388	LysM domain
TEPIRE1_RS12595	COG1215	transferase activity, transferring glycosyl groups
TEPIRE1_RS12615	COG0129	dihydroxy-acid dehydratase activity
TEPIRE1_RS12620	COG0440	acetolactate synthase activity
TEPIRE1_RS12625	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TEPIRE1_RS12640	COG2201	protein-glutamate methylesterase activity
TEPIRE1_RS12650	COG2197	response regulator
TEPIRE1_RS12655	COG0784	Response regulator, receiver
TEPIRE1_RS12655	COG0835	chemotaxis
TEPIRE1_RS12670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TEPIRE1_RS12675	COG1802	Transcriptional regulator
TEPIRE1_RS12680	COG0840	transmembrane signaling receptor activity
TEPIRE1_RS12685	COG4251	negative regulation of phosphorylation
TEPIRE1_RS12695	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TEPIRE1_RS12695	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TEPIRE1_RS12700	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TEPIRE1_RS12700	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TEPIRE1_RS12705	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TEPIRE1_RS12710	COG3715	PTS system
TEPIRE1_RS12715	COG3716	PTS system mannose fructose sorbose family IID component
TEPIRE1_RS12720	COG1063	alcohol dehydrogenase
TEPIRE1_RS12735	COG0446	pyridine nucleotide-disulphide oxidoreductase
TEPIRE1_RS12745	COG0840	transmembrane signaling receptor activity
TEPIRE1_RS12760	COG3829	transcription factor binding
TEPIRE1_RS12765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TEPIRE1_RS12770	COG1307	EDD domain protein, DegV family
TEPIRE1_RS12815	COG1671	Belongs to the UPF0178 family
TEPIRE1_RS12830	COG1408	metallophosphoesterase
TEPIRE1_RS12835	COG0708	Exodeoxyribonuclease III
TEPIRE1_RS12850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TEPIRE1_RS12850	COG0425	Belongs to the sulfur carrier protein TusA family
TEPIRE1_RS12855	COG2391	methyltransferase activity
TEPIRE1_RS12860	COG0583	DNA-binding transcription factor activity
TEPIRE1_RS12870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TEPIRE1_RS12870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TEPIRE1_RS12875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TEPIRE1_RS12875	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TEPIRE1_RS12875	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TEPIRE1_RS12880	COG1105	Belongs to the carbohydrate kinase PfkB family
TEPIRE1_RS12885	COG1349	DNA-binding transcription factor activity
TEPIRE1_RS12890	COG1151	hydroxylamine reductase activity
TEPIRE1_RS12905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TEPIRE1_RS12920	COG3177	Filamentation induced by cAMP protein fic
TEPIRE1_RS12935	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TEPIRE1_RS12975	COG0646	methionine synthase
TEPIRE1_RS12975	COG1410	methionine synthase
TEPIRE1_RS12990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TEPIRE1_RS12995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TEPIRE1_RS13020	COG5002	protein histidine kinase activity
TEPIRE1_RS13025	COG0745	RESPONSE REGULATOR receiver
TEPIRE1_RS13065	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TEPIRE1_RS13075	COG0305	Participates in initiation and elongation during chromosome replication
TEPIRE1_RS13080	COG0359	binds to the 23S rRNA
TEPIRE1_RS13085	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TEPIRE1_RS13090	COG4241	membrane
TEPIRE1_RS13095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TEPIRE1_RS13105	COG0360	Binds together with S18 to 16S ribosomal RNA
TEPIRE1_RS13110	COG4481	Protein conserved in bacteria
TEPIRE1_RS13115	COG0668	transmembrane transport
TEPIRE1_RS13130	COG3949	Membrane
TEPIRE1_RS13145	COG0741	lytic transglycosylase activity
TEPIRE1_RS13145	COG0739	heme binding
TEPIRE1_RS13145	COG1196	nuclear chromosome segregation
TEPIRE1_RS13160	COG1943	Transposase
TEPIRE1_RS13165	COG1475	DNA binding
TEPIRE1_RS13170	COG1192	Involved in chromosome partitioning
TEPIRE1_RS13180	COG0357	Ribosomal RNA small subunit methyltransferase G
TEPIRE1_RS13185	COG0445	tRNA wobble uridine modification
TEPIRE1_RS13190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TEPIRE1_RS13195	COG1847	R3H domain protein
TEPIRE1_RS13200	COG0706	membrane insertase activity
TEPIRE1_RS13205	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TEPIRE1_RS13210	COG0594	ribonuclease P activity
TEPIRE1_RS13215	COG0230	Belongs to the bacterial ribosomal protein bL34 family