locus-tag	class	description
Tbon_RS00015	COG0569	domain protein
Tbon_RS00025	COG0077	Prephenate dehydratase
Tbon_RS00025	COG1605	Chorismate mutase
Tbon_RS00050	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Tbon_RS00050	COG3608	succinylglutamate desuccinylase aspartoacylase
Tbon_RS00055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tbon_RS00080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tbon_RS00085	COG1024	Enoyl-CoA hydratase
Tbon_RS00095	COG0596	Alpha beta hydrolase
Tbon_RS00100	COG0596	Alpha beta hydrolase
Tbon_RS00120	COG0583	DNA-binding transcription factor activity
Tbon_RS00130	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tbon_RS00135	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tbon_RS00135	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tbon_RS00140	COG0516	GMP reductase activity
Tbon_RS00140	COG0517	IMP dehydrogenase activity
Tbon_RS00175	COG0606	chelatase, subunit chli
Tbon_RS00180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tbon_RS00185	COG0124	histidyl-tRNA synthetase
Tbon_RS00190	COG0484	heat shock protein binding
Tbon_RS00210	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tbon_RS00215	COG0835	chemotaxis
Tbon_RS00220	COG0643	Histidine kinase
Tbon_RS00220	COG2198	Histidine kinase
Tbon_RS00230	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Tbon_RS00235	COG2201	protein-glutamate methylesterase activity
Tbon_RS00240	COG2201	protein-glutamate methylesterase activity
Tbon_RS00245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tbon_RS00260	COG0427	acetyl-CoA hydrolase
Tbon_RS00265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS00270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS00275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tbon_RS00280	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS00330	COG2267	carboxylic ester hydrolase activity
Tbon_RS00340	COG1193	negative regulation of DNA recombination
Tbon_RS00345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tbon_RS00375	COG0237	dephospho-CoA kinase activity
Tbon_RS00410	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Tbon_RS00415	COG1022	Amp-dependent synthetase and ligase
Tbon_RS00420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_RS00425	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS00430	COG1215	transferase activity, transferring glycosyl groups
Tbon_RS00455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tbon_RS00465	COG1051	belongs to the nudix hydrolase family
Tbon_RS00480	COG4149	molybdate abc transporter
Tbon_RS00525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tbon_RS00545	COG0148	phosphopyruvate hydratase activity
Tbon_RS00550	COG0242	peptide deformylase activity
Tbon_RS00560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tbon_RS00565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tbon_RS00570	COG1201	RNA secondary structure unwinding
Tbon_RS00580	COG1733	regulation of RNA biosynthetic process
Tbon_RS00585	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Tbon_RS00590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_RS00630	COG1309	transcriptional regulator
Tbon_RS00640	COG1490	D-aminoacyl-tRNA deacylase activity
Tbon_RS00645	COG0442	prolyl-tRNA aminoacylation
Tbon_RS00665	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Tbon_RS00670	COG0538	isocitrate dehydrogenase activity
Tbon_RS00680	COG1199	ATP-dependent helicase activity
Tbon_RS00685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tbon_RS00705	COG1994	Peptidase M50
Tbon_RS00710	COG0287	Prephenate dehydrogenase
Tbon_RS00715	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tbon_RS00725	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS00740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Tbon_RS00780	COG0444	Belongs to the ABC transporter superfamily
Tbon_RS00785	COG4608	Belongs to the ABC transporter superfamily
Tbon_RS00795	COG2815	serine threonine protein kinase
Tbon_RS00795	COG0515	serine threonine protein kinase
Tbon_RS00805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tbon_RS00810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Tbon_RS00815	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Tbon_RS00820	COG1077	Cell shape determining protein MreB Mrl
Tbon_RS00825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tbon_RS00830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tbon_RS00835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tbon_RS00840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tbon_RS00845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tbon_RS00850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tbon_RS00855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tbon_RS00860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tbon_RS00865	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tbon_RS00870	COG0356	it plays a direct role in the translocation of protons across the membrane
Tbon_RS00895	COG0284	orotidine-5'-phosphate decarboxylase activity
Tbon_RS00900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tbon_RS00905	COG2045	Belongs to the ComB family
Tbon_RS00920	COG0714	Associated with various cellular activities
Tbon_RS00950	COG2096	Adenosyltransferase
Tbon_RS00955	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS00965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tbon_RS00970	COG0484	heat shock protein binding
Tbon_RS00980	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tbon_RS00985	COG0540	Belongs to the ATCase OTCase family
Tbon_RS00990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tbon_RS00995	COG0505	Belongs to the CarA family
Tbon_RS01005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tbon_RS01010	COG0543	2 iron, 2 sulfur cluster binding
Tbon_RS01015	COG1058	Belongs to the CinA family
Tbon_RS01015	COG1546	Belongs to the CinA family
Tbon_RS01020	COG0384	phenazine biosynthesis protein PhzF
Tbon_RS01030	COG0318	PFAM AMP-dependent synthetase and ligase
Tbon_RS01035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Tbon_RS01040	COG0569	domain protein
Tbon_RS01060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tbon_RS01085	COG0668	transmembrane transport
Tbon_RS01095	COG0129	dihydroxy-acid dehydratase activity
Tbon_RS01105	COG4770	biotin carboxylase activity
Tbon_RS01135	COG0489	protein tyrosine kinase activity
Tbon_RS01165	COG1846	Transcriptional regulator
Tbon_RS01180	COG0667	Aldo Keto reductase
Tbon_RS01190	COG0166	Belongs to the GPI family
Tbon_RS01205	COG2897	thiosulfate sulfurtransferase activity
Tbon_RS01210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tbon_RS01215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tbon_RS01235	COG4797	methyltransferase
Tbon_RS01235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tbon_RS01240	COG0436	Aminotransferase
Tbon_RS01255	COG0045	succinate-CoA ligase (ADP-forming) activity
Tbon_RS01255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tbon_RS01255	COG1042	CoA-binding domain protein
Tbon_RS01265	COG2197	response regulator
Tbon_RS01270	COG0424	maF-like protein
Tbon_RS01275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tbon_RS01300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tbon_RS01310	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS01315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS01320	COG2226	methyltransferase
Tbon_RS01335	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Tbon_RS01350	COG0321	lipoyl(octanoyl) transferase activity
Tbon_RS01355	COG0217	transcriptional regulatory protein
Tbon_RS01390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tbon_RS01395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tbon_RS01405	COG0250	Participates in transcription elongation, termination and antitermination
Tbon_RS01415	COG0601	transmembrane transport
Tbon_RS01425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tbon_RS01430	COG0081	regulation of translation
Tbon_RS01465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tbon_RS01470	COG0644	oxidoreductase
Tbon_RS01480	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS01485	COG0328	RNA-DNA hybrid ribonuclease activity
Tbon_RS01495	COG0497	DNA recombination
Tbon_RS01500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tbon_RS01505	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Tbon_RS01510	COG0028	Belongs to the TPP enzyme family
Tbon_RS01515	COG0339	signal peptide processing
Tbon_RS01545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tbon_RS01550	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tbon_RS01555	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Tbon_RS01560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tbon_RS01570	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tbon_RS01575	COG1194	a g-specific adenine glycosylase
Tbon_RS01590	COG1228	amidohydrolase
Tbon_RS01605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tbon_RS01625	COG1136	(ABC) transporter
Tbon_RS01625	COG4591	ABC-type transport system involved in lipoprotein release permease component
Tbon_RS01630	COG1136	(ABC) transporter
Tbon_RS01630	COG0577	efflux transmembrane transporter activity
Tbon_RS01655	COG0196	riboflavin kinase activity
Tbon_RS01660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tbon_RS01695	COG0243	molybdopterin cofactor binding
Tbon_RS01725	COG1397	ADP-ribosylglycohydrolase
Tbon_RS01730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tbon_RS01740	COG4770	biotin carboxylase activity
Tbon_RS01785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Tbon_RS01790	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS01800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tbon_RS01805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tbon_RS01810	COG0805	protein transport
Tbon_RS01820	COG1573	uracil-dna glycosylase
Tbon_RS01825	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Tbon_RS01830	COG1674	ftsk spoiiie
Tbon_RS01835	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Tbon_RS01835	COG0825	malonyl-CoA metabolic process
Tbon_RS01840	COG0730	response to heat
Tbon_RS01850	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Tbon_RS01865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tbon_RS01870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tbon_RS01880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tbon_RS01905	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tbon_RS01915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Tbon_RS01920	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tbon_RS01925	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tbon_RS01930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tbon_RS01935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tbon_RS01940	COG0772	Belongs to the SEDS family
Tbon_RS01950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tbon_RS01955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tbon_RS01960	COG0768	penicillin binding
Tbon_RS01970	COG0275	rRNA processing
Tbon_RS01975	COG2001	Belongs to the MraZ family
Tbon_RS01980	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tbon_RS01985	COG0336	Belongs to the RNA methyltransferase TrmD family
Tbon_RS02000	COG0577	efflux transmembrane transporter activity
Tbon_RS02005	COG1136	(ABC) transporter
Tbon_RS02010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tbon_RS02020	COG1959	2 iron, 2 sulfur cluster binding
Tbon_RS02020	COG1295	ribonuclease BN
Tbon_RS02030	COG0396	ATPase activity
Tbon_RS02035	COG0719	Fe-S assembly protein
Tbon_RS02040	COG0719	Fe-S assembly protein
Tbon_RS02050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tbon_RS02055	COG0822	iron-sulfur transferase activity
Tbon_RS02060	COG2151	metal-sulfur cluster biosynthetic enzyme
Tbon_RS02065	COG1024	Enoyl-CoA hydratase
Tbon_RS02085	COG1024	Enoyl-CoA hydratase
Tbon_RS02090	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Tbon_RS02090	COG0517	IMP dehydrogenase activity
Tbon_RS02105	COG0582	viral genome integration into host DNA
Tbon_RS02110	COG1525	nuclease
Tbon_RS02160	COG1484	DNA-dependent DNA replication
Tbon_RS02275	COG0739	heme binding
Tbon_RS02325	COG0493	'glutamate synthase
Tbon_RS02325	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tbon_RS02345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_RS02365	COG1024	Enoyl-CoA hydratase
Tbon_RS02370	COG1560	Kdo2-lipid A biosynthetic process
Tbon_RS02380	COG0613	PHP domain protein
Tbon_RS02385	COG0438	transferase activity, transferring glycosyl groups
Tbon_RS02390	COG1213	nucleotidyl transferase
Tbon_RS02390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tbon_RS02410	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS02415	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Tbon_RS02425	COG0673	inositol 2-dehydrogenase activity
Tbon_RS02445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tbon_RS02450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tbon_RS02470	COG0085	RNA polymerase activity
Tbon_RS02500	COG0542	response to heat
Tbon_RS02505	COG0539	negative regulation of cytoplasmic translation
Tbon_RS02525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tbon_RS02530	COG0193	aminoacyl-tRNA hydrolase activity
Tbon_RS02550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tbon_RS02560	COG2084	Dehydrogenase
Tbon_RS02565	COG3706	GGDEF domain
Tbon_RS02565	COG0745	RESPONSE REGULATOR receiver
Tbon_RS02570	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS02585	COG2723	6-phospho-beta-galactosidase activity
Tbon_RS02590	COG0386	Belongs to the glutathione peroxidase family
Tbon_RS02600	COG1940	carbohydrate kinase activity
Tbon_RS02605	COG0412	Dienelactone hydrolase
Tbon_RS02615	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Tbon_RS02625	COG1678	Uncharacterized ACR, COG1678
Tbon_RS02635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS02650	COG1187	pseudouridine synthase activity
Tbon_RS02665	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tbon_RS02675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tbon_RS02720	COG0183	Belongs to the thiolase family
Tbon_RS02730	COG0628	permease
Tbon_RS02740	COG0440	acetolactate synthase activity
Tbon_RS02745	COG0028	Belongs to the TPP enzyme family
Tbon_RS02755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tbon_RS02760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tbon_RS02775	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tbon_RS02785	COG0159	tryptophan synthase activity
Tbon_RS02800	COG0133	tryptophan synthase activity
Tbon_RS02810	COG0134	indole-3-glycerol-phosphate synthase activity
Tbon_RS02815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tbon_RS02820	COG0512	Glutamine amidotransferase of anthranilate synthase
Tbon_RS02830	COG0546	phosphoglycolate phosphatase activity
Tbon_RS02850	COG0180	Tryptophanyl-tRNA synthetase
Tbon_RS02865	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Tbon_RS02880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Tbon_RS02890	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tbon_RS02890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tbon_RS02895	COG0372	Belongs to the citrate synthase family
Tbon_RS02910	COG0802	atpase or kinase
Tbon_RS02915	COG1214	PFAM Peptidase M22, glycoprotease
Tbon_RS02920	COG0105	UTP biosynthetic process
Tbon_RS02930	COG1473	amidohydrolase
Tbon_RS02965	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tbon_RS02975	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS02995	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Tbon_RS03005	COG0747	negative chemotaxis
Tbon_RS03015	COG1305	Transglutaminase-like
Tbon_RS03025	COG0714	Associated with various cellular activities
Tbon_RS03030	COG1309	transcriptional regulator
Tbon_RS03035	COG2409	Drug exporters of the RND superfamily
Tbon_RS03040	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS03075	COG0456	acetyltransferase
Tbon_RS03090	COG0789	Transcriptional regulator
Tbon_RS03095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tbon_RS03115	COG0673	inositol 2-dehydrogenase activity
Tbon_RS03120	COG0546	phosphoglycolate phosphatase activity
Tbon_RS03130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS03150	COG0778	Nitroreductase
Tbon_RS03165	COG0012	GTP binding
Tbon_RS03190	COG0747	negative chemotaxis
Tbon_RS03195	COG0601	transmembrane transport
Tbon_RS03200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tbon_RS03225	COG2030	dehydratase
Tbon_RS03235	COG2124	cytochrome p450
Tbon_RS03240	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tbon_RS03245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tbon_RS03255	COG2132	Multicopper oxidase
Tbon_RS03275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tbon_RS03350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tbon_RS03355	COG0066	3-isopropylmalate dehydratase activity
Tbon_RS03365	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Tbon_RS03375	COG0473	3-isopropylmalate dehydrogenase activity
Tbon_RS03380	COG1063	alcohol dehydrogenase
Tbon_RS03400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tbon_RS03405	COG0717	Belongs to the dCTP deaminase family
Tbon_RS03410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tbon_RS03415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_RS03425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS03440	COG1862	Preprotein translocase
Tbon_RS03445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tbon_RS03450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tbon_RS03475	COG1122	ATPase activity
Tbon_RS03500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tbon_RS03530	COG0681	Belongs to the peptidase S26 family
Tbon_RS03535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tbon_RS03590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS03605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tbon_RS03615	COG0438	transferase activity, transferring glycosyl groups
Tbon_RS03640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tbon_RS03645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tbon_RS03670	COG0367	asparagine synthase
Tbon_RS03675	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS03690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tbon_RS03695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Tbon_RS03700	COG1116	anion transmembrane transporter activity
Tbon_RS03715	COG4106	trans-aconitate 2-methyltransferase activity
Tbon_RS03730	COG0277	FAD linked oxidase domain protein
Tbon_RS03735	COG0277	FAD linked oxidase domain protein
Tbon_RS03740	COG0247	lactate metabolic process
Tbon_RS03745	COG3706	GGDEF domain
Tbon_RS03765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tbon_RS03765	COG5549	protein import
Tbon_RS03770	COG0686	Belongs to the AlaDH PNT family
Tbon_RS03785	COG2111	Na H antiporter
Tbon_RS03800	COG1863	multisubunit Na H antiporter MnhE subunit
Tbon_RS03805	COG2212	antiporter activity
Tbon_RS03810	COG1320	monovalent cation:proton antiporter activity
Tbon_RS03830	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS03835	COG1024	Enoyl-CoA hydratase
Tbon_RS03840	COG2226	methyltransferase
Tbon_RS03845	COG0416	fatty acid biosynthetic process
Tbon_RS03880	COG1597	lipid kinase activity
Tbon_RS03885	COG0183	Belongs to the thiolase family
Tbon_RS03890	COG2072	flavoprotein involved in K transport
Tbon_RS03945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tbon_RS03970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tbon_RS03985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Tbon_RS04005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tbon_RS04010	COG0357	Ribosomal RNA small subunit methyltransferase G
Tbon_RS04040	COG1104	cysteine desulfurase activity
Tbon_RS04065	COG1494	fructose-1,6-bisphosphatase
Tbon_RS04080	COG1120	ATPase activity
Tbon_RS04085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tbon_RS04110	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS04120	COG4691	Plasmid stability protein
Tbon_RS04130	COG1024	Enoyl-CoA hydratase
Tbon_RS04135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Tbon_RS04140	COG1256	bacterial-type flagellum assembly
Tbon_RS04140	COG4786	Flagellar basal body rod
Tbon_RS04160	COG4786	Flagellar basal body rod
Tbon_RS04175	COG1191	sigma factor activity
Tbon_RS04195	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tbon_RS04200	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tbon_RS04205	COG1684	flagellar biosynthetic protein fliR
Tbon_RS04210	COG1987	bacterial-type flagellum assembly
Tbon_RS04215	COG1338	Plays a role in the flagellum-specific transport system
Tbon_RS04225	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tbon_RS04225	COG1776	CheC inhibitor of MCP methylation
Tbon_RS04240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Tbon_RS04265	COG4552	Acetyltransferase involved in intracellular survival and related
Tbon_RS04270	COG0612	Peptidase, M16
Tbon_RS04280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tbon_RS04295	COG1595	DNA-templated transcription, initiation
Tbon_RS04305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Tbon_RS04345	COG0517	IMP dehydrogenase activity
Tbon_RS04345	COG1994	Peptidase M50
Tbon_RS04350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tbon_RS04355	COG3608	succinylglutamate desuccinylase aspartoacylase
Tbon_RS04355	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Tbon_RS04360	COG0588	phosphoglycerate mutase activity
Tbon_RS04375	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS04385	COG1024	Enoyl-CoA hydratase
Tbon_RS04395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_RS04405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tbon_RS04425	COG1253	flavin adenine dinucleotide binding
Tbon_RS04430	COG1132	(ABC) transporter
Tbon_RS04435	COG1132	(ABC) transporter
Tbon_RS04445	COG0500	methyltransferase
Tbon_RS04450	COG0187	DNA topoisomerase II activity
Tbon_RS04460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tbon_RS04490	COG2326	polyphosphate kinase activity
Tbon_RS04495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tbon_RS04505	COG0460	homoserine dehydrogenase
Tbon_RS04515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tbon_RS04525	COG0360	Binds together with S18 to 16S ribosomal RNA
Tbon_RS04530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tbon_RS04550	COG1024	Enoyl-CoA hydratase
Tbon_RS04555	COG2353	YceI-like domain
Tbon_RS04570	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS04580	COG1024	Enoyl-CoA hydratase
Tbon_RS04610	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tbon_RS04640	COG2267	carboxylic ester hydrolase activity
Tbon_RS04650	COG0681	Belongs to the peptidase S26 family
Tbon_RS04655	COG1024	Enoyl-CoA hydratase
Tbon_RS04660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tbon_RS04665	COG0222	ribosome binding
Tbon_RS04670	COG4651	solute:proton antiporter activity
Tbon_RS04670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Tbon_RS04675	COG1063	alcohol dehydrogenase
Tbon_RS04680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tbon_RS04690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Tbon_RS04700	COG2204	response regulator
Tbon_RS04705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tbon_RS04720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tbon_RS04735	COG1595	DNA-templated transcription, initiation
Tbon_RS04740	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tbon_RS04785	COG0616	signal peptide processing
Tbon_RS04820	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Tbon_RS04825	COG0318	PFAM AMP-dependent synthetase and ligase
Tbon_RS04830	COG1024	Enoyl-CoA hydratase
Tbon_RS04845	COG4867	von Willebrand factor, type A
Tbon_RS04850	COG2197	response regulator
Tbon_RS04870	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tbon_RS04875	COG0473	3-isopropylmalate dehydrogenase activity
Tbon_RS04895	COG0792	nuclease activity
Tbon_RS04900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tbon_RS04905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tbon_RS04925	COG2267	carboxylic ester hydrolase activity
Tbon_RS04955	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS04960	COG0484	heat shock protein binding
Tbon_RS04965	COG2264	protein methyltransferase activity
Tbon_RS04980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tbon_RS04985	COG0174	glutamine synthetase
Tbon_RS05005	COG0492	ferredoxin-NADP+ reductase activity
Tbon_RS05010	COG3118	belongs to the thioredoxin family
Tbon_RS05015	COG1937	Protein conserved in bacteria
Tbon_RS05020	COG1929	Belongs to the glycerate kinase type-1 family
Tbon_RS05045	COG2414	aldehyde ferredoxin oxidoreductase
Tbon_RS05055	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Tbon_RS05070	COG3852	Histidine kinase
Tbon_RS05085	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tbon_RS05090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_RS05100	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Tbon_RS05115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_RS05120	COG1410	methionine synthase
Tbon_RS05120	COG0646	methionine synthase
Tbon_RS05145	COG0456	acetyltransferase
Tbon_RS05145	COG1214	PFAM Peptidase M22, glycoprotease
Tbon_RS05155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tbon_RS05160	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tbon_RS05175	COG2945	thiolester hydrolase activity
Tbon_RS05175	COG0596	Alpha beta hydrolase
Tbon_RS05180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tbon_RS05205	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tbon_RS05210	COG1518	maintenance of DNA repeat elements
Tbon_RS05210	COG1468	defense response to virus
Tbon_RS05315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Tbon_RS05335	COG2124	cytochrome p450
Tbon_RS05380	COG0270	DNA (cytosine-5-)-methyltransferase activity
Tbon_RS05400	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS05405	COG0561	phosphatase activity
Tbon_RS05435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_RS05445	COG1132	(ABC) transporter
Tbon_RS05450	COG1132	(ABC) transporter
Tbon_RS05455	COG1333	cytochrome c biogenesis protein
Tbon_RS05460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tbon_RS05470	COG1205	dead DEAH box helicase
Tbon_RS05470	COG1111	helicase
Tbon_RS05485	COG0138	bifunctional purine biosynthesis protein purh
Tbon_RS05490	COG0494	nUDIX hydrolase
Tbon_RS05510	COG1309	transcriptional regulator
Tbon_RS05515	COG0183	Belongs to the thiolase family
Tbon_RS05525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tbon_RS05530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tbon_RS05535	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Tbon_RS05545	COG0747	negative chemotaxis
Tbon_RS05565	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Tbon_RS05570	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS05575	COG0483	inositol monophosphate 1-phosphatase activity
Tbon_RS05580	COG3386	PFAM SMP-30 Gluconolaconase
Tbon_RS05585	COG0443	Heat shock 70 kDa protein
Tbon_RS05590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tbon_RS05595	COG1420	regulation of RNA biosynthetic process
Tbon_RS05615	COG0071	Belongs to the small heat shock protein (HSP20) family
Tbon_RS05640	COG1999	signal sequence binding
Tbon_RS05655	COG0300	oxidoreductase activity
Tbon_RS05660	COG0588	phosphoglycerate mutase activity
Tbon_RS05665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tbon_RS05670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tbon_RS05675	COG0601	transmembrane transport
Tbon_RS05680	COG0747	negative chemotaxis
Tbon_RS05710	COG3852	Histidine kinase
Tbon_RS05715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tbon_RS05745	COG1104	cysteine desulfurase activity
Tbon_RS05750	COG0527	aspartate kinase activity
Tbon_RS05765	COG2124	cytochrome p450
Tbon_RS05770	COG0135	phosphoribosylanthranilate isomerase activity
Tbon_RS05775	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Tbon_RS05780	COG0484	heat shock protein binding
Tbon_RS05800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tbon_RS05810	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Tbon_RS05830	COG0745	RESPONSE REGULATOR receiver
Tbon_RS05835	COG5002	protein histidine kinase activity
Tbon_RS05855	COG0459	protein refolding
Tbon_RS05860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tbon_RS05880	COG1024	Enoyl-CoA hydratase
Tbon_RS05900	COG0598	Magnesium transport protein CorA
Tbon_RS05910	COG1595	DNA-templated transcription, initiation
Tbon_RS05945	COG1045	serine acetyltransferase
Tbon_RS05950	COG0019	diaminopimelate decarboxylase activity
Tbon_RS05955	COG0745	RESPONSE REGULATOR receiver
Tbon_RS05965	COG1797	cobyrinic acid a,c-diamide synthase activity
Tbon_RS05985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tbon_RS05990	COG0724	RNA recognition motif
Tbon_RS05995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Tbon_RS06000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tbon_RS06005	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Tbon_RS06015	COG0215	cysteine-tRNA ligase activity
Tbon_RS06035	COG2119	membrane
Tbon_RS06070	COG0488	(ABC) transporter
Tbon_RS06075	COG0277	FAD linked oxidase domain protein
Tbon_RS06085	COG1597	lipid kinase activity
Tbon_RS06085	COG1803	Methylglyoxal synthase
Tbon_RS06100	COG3706	GGDEF domain
Tbon_RS06100	COG0745	RESPONSE REGULATOR receiver
Tbon_RS06125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tbon_RS06170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tbon_RS06185	COG0500	methyltransferase
Tbon_RS06205	COG1024	Enoyl-CoA hydratase
Tbon_RS06220	COG3842	ATPase activity
Tbon_RS06225	COG1178	ABC-type Fe3 transport system permease component
Tbon_RS06235	COG0592	DNA-directed DNA polymerase activity
Tbon_RS06245	COG1881	PFAM PEBP family protein
Tbon_RS06260	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Tbon_RS06280	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Tbon_RS06300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tbon_RS06335	COG0411	ABC transporter
Tbon_RS06365	COG1575	Belongs to the MenA family. Type 1 subfamily
Tbon_RS06370	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tbon_RS06385	COG0556	nucleotide-excision repair
Tbon_RS06395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Tbon_RS06410	COG1024	Enoyl-CoA hydratase
Tbon_RS06415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tbon_RS06420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tbon_RS06430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tbon_RS06430	COG0574	Belongs to the PEP-utilizing enzyme family
Tbon_RS06450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tbon_RS06465	COG1404	Belongs to the peptidase S8 family
Tbon_RS06480	COG2894	cell division
Tbon_RS06485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tbon_RS06490	COG0741	lytic transglycosylase activity
Tbon_RS06490	COG1196	nuclear chromosome segregation
Tbon_RS06490	COG0739	heme binding
Tbon_RS06495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Tbon_RS06505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tbon_RS06520	COG1847	R3H domain protein
Tbon_RS06520	COG1847	R3H domain protein
Tbon_RS06530	COG1192	Involved in chromosome partitioning
Tbon_RS06535	COG1475	DNA binding
Tbon_RS06545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tbon_RS06550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tbon_RS06550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tbon_RS06565	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS06605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_RS06635	COG3845	ABC transporter
Tbon_RS06650	COG1595	DNA-templated transcription, initiation
Tbon_RS06655	COG1215	transferase activity, transferring glycosyl groups
Tbon_RS06715	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tbon_RS06740	COG0281	malic enzyme
Tbon_RS06755	COG1832	CoA-binding protein
Tbon_RS06760	COG0183	Belongs to the thiolase family
Tbon_RS06770	COG2003	Belongs to the UPF0758 family
Tbon_RS06775	COG3591	Belongs to the peptidase S1B family
Tbon_RS06790	COG3103	Sh3 type 3 domain protein
Tbon_RS06790	COG0791	NLP P60 protein
Tbon_RS06790	COG1388	LysM domain
Tbon_RS06795	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Tbon_RS06810	COG2814	Major facilitator Superfamily
Tbon_RS06825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tbon_RS06830	COG3854	ATPases associated with a variety of cellular activities
Tbon_RS06840	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Tbon_RS06845	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Tbon_RS06890	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tbon_RS06940	COG0617	tRNA 3'-terminal CCA addition
Tbon_RS06945	COG1231	oxidoreductase activity
Tbon_RS06955	COG0347	Belongs to the P(II) protein family
Tbon_RS06960	COG0004	ammonium transporteR
Tbon_RS06965	COG2086	electron transfer activity
Tbon_RS06970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Tbon_RS06985	COG1703	isobutyryl-CoA mutase activity
Tbon_RS06990	COG0438	transferase activity, transferring glycosyl groups
Tbon_RS07000	COG0659	secondary active sulfate transmembrane transporter activity
Tbon_RS07010	COG3706	GGDEF domain
Tbon_RS07040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tbon_RS07045	COG1774	PSP1 C-terminal conserved region
Tbon_RS07065	COG0667	Aldo Keto reductase
Tbon_RS07080	COG1575	Belongs to the MenA family. Type 1 subfamily
Tbon_RS07085	COG2226	methyltransferase
Tbon_RS07090	COG1215	transferase activity, transferring glycosyl groups
Tbon_RS07125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tbon_RS07130	COG1610	YqeY-like protein
Tbon_RS07135	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Tbon_RS07140	COG1480	7TM receptor with intracellular HD hydrolase
Tbon_RS07145	COG0047	phosphoribosylformylglycinamidine synthase activity
Tbon_RS07155	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tbon_RS07160	COG1994	Peptidase M50
Tbon_RS07160	COG0517	IMP dehydrogenase activity
Tbon_RS07170	COG0768	penicillin binding
Tbon_RS07175	COG1024	Enoyl-CoA hydratase
Tbon_RS07180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Tbon_RS07185	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tbon_RS07190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tbon_RS07190	COG1213	nucleotidyl transferase
Tbon_RS07240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tbon_RS07245	COG2181	nitrate reductase activity
Tbon_RS07245	COG0247	lactate metabolic process
Tbon_RS07250	COG0318	PFAM AMP-dependent synthetase and ligase
Tbon_RS07290	COG1735	metal-dependent hydrolase with the TIM-barrel fold
Tbon_RS07315	COG2267	carboxylic ester hydrolase activity
Tbon_RS07320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tbon_RS07335	COG2814	Major facilitator Superfamily
Tbon_RS07345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tbon_RS07355	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tbon_RS07360	COG0724	RNA recognition motif
Tbon_RS07370	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tbon_RS07380	COG2226	methyltransferase
Tbon_RS07395	COG1053	succinate dehydrogenase
Tbon_RS07410	COG0482	sulfurtransferase activity
Tbon_RS07415	COG0799	negative regulation of ribosome biogenesis
Tbon_RS07420	COG1024	Enoyl-CoA hydratase
Tbon_RS07435	COG1234	tRNA 3'-trailer cleavage
Tbon_RS07445	COG0745	RESPONSE REGULATOR receiver
Tbon_RS07450	COG1733	regulation of RNA biosynthetic process
Tbon_RS07455	COG1388	LysM domain
Tbon_RS07460	COG0701	Predicted permease
Tbon_RS07470	COG0823	Involved in the tonB-independent uptake of proteins
Tbon_RS07495	COG0739	heme binding
Tbon_RS07495	COG0741	lytic transglycosylase activity
Tbon_RS07495	COG1196	nuclear chromosome segregation
Tbon_RS07505	COG0438	transferase activity, transferring glycosyl groups
Tbon_RS07515	COG0702	epimerase
Tbon_RS07540	COG2226	methyltransferase
Tbon_RS07555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tbon_RS07565	COG3191	aminopeptidase activity
Tbon_RS07570	COG0588	phosphoglycerate mutase activity
Tbon_RS07585	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Tbon_RS07600	COG2267	carboxylic ester hydrolase activity
Tbon_RS07605	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tbon_RS07620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_RS07630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tbon_RS07630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tbon_RS07645	COG0601	transmembrane transport
Tbon_RS07655	COG2124	cytochrome p450
Tbon_RS07660	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS07670	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS07680	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS07690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tbon_RS07695	COG0022	dehydrogenase e1 component
Tbon_RS07700	COG3199	ATP-NAD kinase
Tbon_RS07705	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tbon_RS07720	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS07755	COG0427	acetyl-CoA hydrolase
Tbon_RS07765	COG2897	thiosulfate sulfurtransferase activity
Tbon_RS07775	COG0504	CTP synthase activity
Tbon_RS07785	COG0672	)-iron permease
Tbon_RS07815	COG0612	Peptidase, M16
Tbon_RS07820	COG0174	glutamine synthetase
Tbon_RS07830	COG2272	Belongs to the type-B carboxylesterase lipase family
Tbon_RS07865	COG1271	oxidase subunit
Tbon_RS07875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_RS07890	COG2267	carboxylic ester hydrolase activity
Tbon_RS07895	COG0739	heme binding
Tbon_RS07910	COG0300	oxidoreductase activity
Tbon_RS07915	COG0268	Binds directly to 16S ribosomal RNA
Tbon_RS07920	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_RS07925	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_RS07930	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_RS07935	COG0649	NAD binding
Tbon_RS07940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tbon_RS07945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_RS07955	COG0713	ATP synthesis coupled electron transport
Tbon_RS07960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tbon_RS07965	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_RS07970	COG1007	ATP synthesis coupled electron transport
Tbon_RS07980	COG0653	protein targeting
Tbon_RS08040	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Tbon_RS08050	COG0602	queuosine metabolic process
Tbon_RS08055	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Tbon_RS08065	COG1959	2 iron, 2 sulfur cluster binding
Tbon_RS08100	COG1528	Iron-storage protein
Tbon_RS08105	COG1024	Enoyl-CoA hydratase
Tbon_RS08135	COG1234	tRNA 3'-trailer cleavage
Tbon_RS08170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tbon_RS08190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tbon_RS08205	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS08245	COG1950	PFAM Membrane protein of
Tbon_RS08250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_RS08270	COG0542	response to heat
Tbon_RS08275	COG0789	Transcriptional regulator
Tbon_RS08280	COG0484	heat shock protein binding
Tbon_RS08285	COG0071	Belongs to the small heat shock protein (HSP20) family
Tbon_RS08295	COG2835	tetraacyldisaccharide 4'-kinase activity
Tbon_RS08300	COG1286	toxin biosynthetic process
Tbon_RS08325	COG0601	transmembrane transport
Tbon_RS08345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_RS08355	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Tbon_RS08380	COG0525	valine-tRNA ligase activity
Tbon_RS08400	COG0513	Belongs to the DEAD box helicase family
Tbon_RS08405	COG1024	Enoyl-CoA hydratase
Tbon_RS08420	COG0739	heme binding
Tbon_RS08420	COG0741	lytic transglycosylase activity
Tbon_RS08420	COG1196	nuclear chromosome segregation
Tbon_RS08430	COG0315	cyclic pyranopterin monophosphate synthase activity
Tbon_RS08435	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tbon_RS08440	COG0459	protein refolding
Tbon_RS08450	COG1254	Belongs to the acylphosphatase family
Tbon_RS08460	COG0778	Nitroreductase
Tbon_RS08485	COG2318	DinB family
Tbon_RS08495	COG0473	3-isopropylmalate dehydrogenase activity
Tbon_RS08500	COG2814	Major facilitator Superfamily
Tbon_RS08505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_RS08510	COG1024	Enoyl-CoA hydratase
Tbon_RS08515	COG2271	Major facilitator Superfamily
Tbon_RS08535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tbon_RS08575	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tbon_RS08580	COG1185	polyribonucleotide nucleotidyltransferase activity
Tbon_RS08605	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS08610	COG3706	GGDEF domain
Tbon_RS08625	COG0469	pyruvate kinase activity
Tbon_RS08635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS08640	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS08650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tbon_RS08660	COG0667	Aldo Keto reductase
Tbon_RS08675	COG1648	precorrin-2 dehydrogenase activity
Tbon_RS08675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tbon_RS08685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tbon_RS08690	COG0181	hydroxymethylbilane synthase activity
Tbon_RS08695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tbon_RS08705	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Tbon_RS08705	COG0392	lysyltransferase activity
Tbon_RS08715	COG2226	methyltransferase
Tbon_RS08725	COG0427	acetyl-CoA hydrolase
Tbon_RS08730	COG1024	Enoyl-CoA hydratase
Tbon_RS08760	COG0427	acetyl-CoA hydrolase
Tbon_RS08765	COG0415	Belongs to the DNA photolyase family
Tbon_RS08770	COG2239	Acts as a magnesium transporter
Tbon_RS08795	COG0704	Plays a role in the regulation of phosphate uptake
Tbon_RS08800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tbon_RS08805	COG0581	inorganic phosphate transmembrane transporter activity
Tbon_RS08810	COG0573	inorganic phosphate transmembrane transporter activity
Tbon_RS08815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tbon_RS08820	COG0745	RESPONSE REGULATOR receiver
Tbon_RS08825	COG5002	protein histidine kinase activity
Tbon_RS08850	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tbon_RS08865	COG1045	serine acetyltransferase
Tbon_RS08880	COG1030	water channel activity
Tbon_RS08900	COG2255	four-way junction helicase activity
Tbon_RS08910	COG0531	amino acid
Tbon_RS08925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_RS08950	COG0359	binds to the 23S rRNA
Tbon_RS08955	COG0305	Participates in initiation and elongation during chromosome replication
Tbon_RS08980	COG0314	molybdopterin synthase activity
Tbon_RS08985	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Tbon_RS08990	COG0714	Associated with various cellular activities
Tbon_RS09025	COG1666	GTP binding
Tbon_RS09050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Tbon_RS09055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_RS09065	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS09075	COG2199	diguanylate cyclase activity
Tbon_RS09075	COG2200	EAL domain
Tbon_RS09075	COG3287	FIST C domain
Tbon_RS09090	COG0302	gtp cyclohydrolase
Tbon_RS09115	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Tbon_RS09120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tbon_RS09130	COG3345	alpha-galactosidase
Tbon_RS09150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS09160	COG1733	regulation of RNA biosynthetic process
Tbon_RS09165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tbon_RS09170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tbon_RS09175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tbon_RS09195	COG0537	adenosine 5'-monophosphoramidase activity
Tbon_RS09205	COG1766	The M ring may be actively involved in energy transduction
Tbon_RS09210	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tbon_RS09220	COG1157	protein secretion by the type III secretion system
Tbon_RS09240	COG1677	Flagellar hook-basal body complex protein FliE
Tbon_RS09250	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Tbon_RS09280	COG1024	Enoyl-CoA hydratase
Tbon_RS09310	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tbon_RS09315	COG0022	dehydrogenase e1 component
Tbon_RS09320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tbon_RS09325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tbon_RS09330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tbon_RS09335	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tbon_RS09340	COG1595	DNA-templated transcription, initiation
Tbon_RS09360	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tbon_RS09365	COG0049	tRNA binding
Tbon_RS09370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tbon_RS09375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tbon_RS09380	COG0051	transcription antitermination factor activity, RNA binding
Tbon_RS09385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tbon_RS09390	COG0088	Forms part of the polypeptide exit tunnel
Tbon_RS09395	COG0089	rRNA binding
Tbon_RS09400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tbon_RS09405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tbon_RS09410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tbon_RS09415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tbon_RS09430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tbon_RS09435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tbon_RS09440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tbon_RS09445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tbon_RS09450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tbon_RS09455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tbon_RS09460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tbon_RS09465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tbon_RS09470	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tbon_RS09475	COG1841	ribosomal large subunit assembly
Tbon_RS09480	COG0200	Binds to the 23S rRNA
Tbon_RS09485	COG0201	protein transport
Tbon_RS09490	COG0563	adenylate kinase activity
Tbon_RS09500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tbon_RS09505	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tbon_RS09515	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tbon_RS09520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tbon_RS09525	COG0202	RNA polymerase activity
Tbon_RS09530	COG0203	ribosomal protein L17
Tbon_RS09540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tbon_RS09545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tbon_RS09565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tbon_RS09570	COG2304	oxidoreductase activity
Tbon_RS09580	COG0714	Associated with various cellular activities
Tbon_RS09590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS09665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tbon_RS09670	COG1121	(ABC) transporter
Tbon_RS09690	COG3852	Histidine kinase
Tbon_RS09715	COG0596	Alpha beta hydrolase
Tbon_RS09715	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tbon_RS09720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tbon_RS09720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tbon_RS09745	COG0083	homoserine kinase activity
Tbon_RS09755	COG0765	amino acid transport
Tbon_RS09770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_RS09785	COG0322	excinuclease ABC activity
Tbon_RS09810	COG1388	LysM domain
Tbon_RS09810	COG3942	CHAP domain
Tbon_RS09845	COG0596	Alpha beta hydrolase
Tbon_RS09850	COG2878	Part of a membrane complex involved in electron transport
Tbon_RS09855	COG2154	pterin-4-alpha-carbinolamine dehydratase
Tbon_RS09920	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tbon_RS09925	COG1307	EDD domain protein, DegV family
Tbon_RS09930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tbon_RS09940	COG0772	Belongs to the SEDS family
Tbon_RS09945	COG0768	penicillin binding
Tbon_RS09955	COG1792	Involved in formation and maintenance of cell shape
Tbon_RS09970	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tbon_RS09980	COG0107	imidazoleglycerol-phosphate synthase activity
Tbon_RS09985	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tbon_RS09985	COG0140	phosphoribosyl-ATP diphosphatase activity
Tbon_RS10020	COG0604	alcohol dehydrogenase
Tbon_RS10025	COG0469	pyruvate kinase activity
Tbon_RS10035	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Tbon_RS10060	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Tbon_RS10070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tbon_RS10075	COG0228	four-way junction DNA binding
Tbon_RS10085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tbon_RS10105	COG0583	DNA-binding transcription factor activity
Tbon_RS10110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tbon_RS10120	COG0393	Putative heavy-metal-binding
Tbon_RS10130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tbon_RS10160	COG1846	Transcriptional regulator
Tbon_RS10170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tbon_RS10185	COG0747	negative chemotaxis
Tbon_RS10190	COG0601	transmembrane transport
Tbon_RS10205	COG0740	serine-type endopeptidase activity
Tbon_RS10210	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tbon_RS10230	COG0431	NADPH-dependent FMN reductase
Tbon_RS10235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tbon_RS10250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tbon_RS10255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tbon_RS10255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tbon_RS10280	COG0312	modulator of DNA gyrase
Tbon_RS10285	COG0312	modulator of DNA gyrase
Tbon_RS10295	COG0822	iron-sulfur transferase activity
Tbon_RS10305	COG0442	prolyl-tRNA aminoacylation
Tbon_RS10310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tbon_RS10315	COG0736	holo-[acyl-carrier-protein] synthase activity
Tbon_RS10320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tbon_RS10320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tbon_RS10325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tbon_RS10330	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Tbon_RS10330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Tbon_RS10340	COG4974	Belongs to the 'phage' integrase family
Tbon_RS10345	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS10355	COG0248	Ppx GppA phosphatase
Tbon_RS10360	COG2062	phosphohistidine phosphatase, SixA
Tbon_RS10405	COG1353	crispr-associated protein
Tbon_RS10415	COG0210	DNA helicase
Tbon_RS10415	COG0210	DNA helicase
Tbon_RS10425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tbon_RS10445	COG2199	diguanylate cyclase activity
Tbon_RS10445	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tbon_RS10475	COG0247	lactate metabolic process
Tbon_RS10480	COG1139	Iron-sulfur cluster binding protein
Tbon_RS10490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_RS10495	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS10505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tbon_RS10525	COG0411	ABC transporter
Tbon_RS10545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS10550	COG2267	carboxylic ester hydrolase activity
Tbon_RS10555	COG3383	formate dehydrogenase (NAD+) activity
Tbon_RS10560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_RS10565	COG2814	Major facilitator Superfamily
Tbon_RS10570	COG0039	L-malate dehydrogenase activity
Tbon_RS10575	COG0481	GTPase activity
Tbon_RS10585	COG1957	nucleoside hydrolase
Tbon_RS10595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tbon_RS10600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tbon_RS10605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tbon_RS10610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tbon_RS10620	COG1131	(ABC) transporter
Tbon_RS10630	COG0762	integral membrane protein
Tbon_RS10635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Tbon_RS10650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Tbon_RS10680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Tbon_RS10685	COG1053	succinate dehydrogenase
Tbon_RS10695	COG0494	nUDIX hydrolase
Tbon_RS10710	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tbon_RS10725	COG0237	dephospho-CoA kinase activity
Tbon_RS10755	COG2199	diguanylate cyclase activity
Tbon_RS10755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tbon_RS10760	COG1321	iron dependent repressor
Tbon_RS10765	COG1695	Transcriptional regulator
Tbon_RS10795	COG1215	transferase activity, transferring glycosyl groups
Tbon_RS10800	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tbon_RS10830	COG3956	TIGRFAM MazG family protein
Tbon_RS10840	COG0297	glycogen (starch) synthase activity
Tbon_RS10855	COG0546	phosphoglycolate phosphatase activity
Tbon_RS10880	COG1570	exodeoxyribonuclease VII activity
Tbon_RS10885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tbon_RS10890	COG0006	proline dipeptidase activity
Tbon_RS10895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tbon_RS10900	COG4974	Belongs to the 'phage' integrase family
Tbon_RS10905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tbon_RS10910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tbon_RS10910	COG0758	DNA mediated transformation
Tbon_RS10920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tbon_RS10935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tbon_RS10940	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tbon_RS10945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tbon_RS10955	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tbon_RS10960	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tbon_RS10965	COG0343	queuine tRNA-ribosyltransferase activity
Tbon_RS11000	COG1492	cobalamin metabolic process
Tbon_RS11005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tbon_RS11010	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Tbon_RS11020	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tbon_RS11030	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Tbon_RS11040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tbon_RS11045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tbon_RS11050	COG0584	glycerophosphoryl diester phosphodiesterase
Tbon_RS11080	COG0831	urea catabolic process
Tbon_RS11090	COG0804	urea catabolic process
Tbon_RS11095	COG0830	nickel cation binding
Tbon_RS11100	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Tbon_RS11115	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tbon_RS11145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tbon_RS11145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tbon_RS11150	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS11155	COG1131	(ABC) transporter
Tbon_RS11170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS11185	COG3118	belongs to the thioredoxin family
Tbon_RS11190	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tbon_RS11195	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS11210	COG2195	Cleaves the N-terminal amino acid of tripeptides
Tbon_RS11225	COG0746	molybdenum cofactor guanylyltransferase activity
Tbon_RS11250	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tbon_RS11255	COG0022	dehydrogenase e1 component
Tbon_RS11260	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tbon_RS11265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tbon_RS11275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tbon_RS11285	COG0667	Aldo Keto reductase
Tbon_RS11295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tbon_RS11305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tbon_RS11305	COG3064	Membrane
Tbon_RS11310	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Tbon_RS11315	COG0195	Participates in both transcription termination and antitermination
Tbon_RS11325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tbon_RS11330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tbon_RS11335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tbon_RS11340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Tbon_RS11345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tbon_RS11365	COG0708	Exodeoxyribonuclease III
Tbon_RS11370	COG2814	Major facilitator Superfamily
Tbon_RS11405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tbon_RS11410	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Tbon_RS11420	COG1160	GTP binding
Tbon_RS11430	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tbon_RS11455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tbon_RS11460	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tbon_RS11465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tbon_RS11475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Tbon_RS11480	COG0151	Belongs to the GarS family
Tbon_RS11485	COG0519	Catalyzes the synthesis of GMP from XMP
Tbon_RS11485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tbon_RS11495	COG0698	ribose 5-phosphate isomerase
Tbon_RS11500	COG0126	phosphoglycerate kinase activity
Tbon_RS11510	COG0149	triose-phosphate isomerase activity
Tbon_RS11515	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tbon_RS11525	COG0436	Aminotransferase
Tbon_RS11530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tbon_RS11535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS11540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS11550	COG1845	cytochrome c oxidase, subunit III
Tbon_RS11560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Tbon_RS11565	COG0109	protoheme IX farnesyltransferase activity
Tbon_RS11570	COG1612	heme a metabolic process
Tbon_RS11575	COG0739	heme binding
Tbon_RS11575	COG1196	nuclear chromosome segregation
Tbon_RS11575	COG0741	lytic transglycosylase activity
Tbon_RS11585	COG2030	dehydratase
Tbon_RS11615	COG0596	Alpha beta hydrolase
Tbon_RS11630	COG0745	RESPONSE REGULATOR receiver
Tbon_RS11680	COG0406	alpha-ribazole phosphatase activity
Tbon_RS11695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tbon_RS11700	COG0483	inositol monophosphate 1-phosphatase activity
Tbon_RS11710	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Tbon_RS11715	COG1331	Highly conserved protein containing a thioredoxin domain
Tbon_RS11745	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS11755	COG1024	Enoyl-CoA hydratase
Tbon_RS11770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tbon_RS11800	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS11830	COG2897	thiosulfate sulfurtransferase activity
Tbon_RS11835	COG0425	Belongs to the sulfur carrier protein TusA family
Tbon_RS11840	COG2391	methyltransferase activity
Tbon_RS11885	COG1111	helicase
Tbon_RS11885	COG1205	dead DEAH box helicase
Tbon_RS11890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tbon_RS11915	COG0582	viral genome integration into host DNA
Tbon_RS11950	COG1968	undecaprenyl-diphosphatase activity
Tbon_RS11955	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
Tbon_RS11985	COG0745	RESPONSE REGULATOR receiver
Tbon_RS12030	COG0423	glycine-tRNA ligase activity
Tbon_RS12035	COG1872	DUF167
Tbon_RS12040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tbon_RS12050	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS12055	COG0768	penicillin binding
Tbon_RS12075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tbon_RS12080	COG0205	6-phosphofructokinase activity
Tbon_RS12100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tbon_RS12120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tbon_RS12125	COG3872	metal-dependent enzyme
Tbon_RS12135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tbon_RS12140	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tbon_RS12145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tbon_RS12155	COG2267	carboxylic ester hydrolase activity
Tbon_RS12160	COG0778	Nitroreductase
Tbon_RS12160	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Tbon_RS12180	COG0756	dUTP diphosphatase activity
Tbon_RS12185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tbon_RS12190	COG0335	large ribosomal subunit rRNA binding
Tbon_RS12195	COG0477	Major facilitator Superfamily
Tbon_RS12220	COG0564	pseudouridine synthase activity
Tbon_RS12225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tbon_RS12230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Tbon_RS12255	COG2197	response regulator
Tbon_RS12270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tbon_RS12280	COG2267	carboxylic ester hydrolase activity
Tbon_RS12285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tbon_RS12290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Tbon_RS12295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tbon_RS12305	COG0006	proline dipeptidase activity
Tbon_RS12335	COG0398	Pfam SNARE associated Golgi protein
Tbon_RS12340	COG0596	Alpha beta hydrolase
Tbon_RS12345	COG0575	Belongs to the CDS family
Tbon_RS12355	COG0233	cytoplasmic translational termination
Tbon_RS12360	COG0528	UMP kinase activity
Tbon_RS12365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tbon_RS12370	COG0052	Belongs to the universal ribosomal protein uS2 family
Tbon_RS12375	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Tbon_RS12375	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Tbon_RS12380	COG0140	phosphoribosyl-ATP diphosphatase activity
Tbon_RS12385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tbon_RS12395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tbon_RS12400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tbon_RS12405	COG0131	Imidazoleglycerol-phosphate dehydratase
Tbon_RS12420	COG0494	nUDIX hydrolase
Tbon_RS12425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tbon_RS12430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tbon_RS12445	COG2070	2-Nitropropane dioxygenase
Tbon_RS12450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS12460	COG1704	LemA family
Tbon_RS12465	COG0501	Belongs to the peptidase M48B family
Tbon_RS12485	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tbon_RS12495	COG0571	ribonuclease III activity
Tbon_RS12500	COG1196	nuclear chromosome segregation
Tbon_RS12505	COG0552	protein localization to endoplasmic reticulum
Tbon_RS12545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tbon_RS12580	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS12585	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tbon_RS12590	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tbon_RS12595	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_RS12600	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tbon_RS12605	COG0649	NAD binding
Tbon_RS12630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tbon_RS12645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tbon_RS12655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tbon_RS12660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tbon_RS12665	COG1381	Involved in DNA repair and RecF pathway recombination
Tbon_RS12675	COG0142	geranyltranstransferase activity
Tbon_RS12680	COG0084	hydrolase, TatD family'
Tbon_RS12685	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tbon_RS12690	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tbon_RS12695	COG0516	GMP reductase activity
Tbon_RS12705	COG0561	phosphatase activity
Tbon_RS12710	COG2890	protein-(glutamine-N5) methyltransferase activity
Tbon_RS12715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tbon_RS12720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tbon_RS12730	COG1692	metallophosphoesterase
Tbon_RS12735	COG1418	mRNA catabolic process
Tbon_RS12740	COG2860	membrane
Tbon_RS12765	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Tbon_RS12770	COG0596	Alpha beta hydrolase
Tbon_RS12775	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Tbon_RS12785	COG0318	PFAM AMP-dependent synthetase and ligase
Tbon_RS12795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tbon_RS12800	COG0750	zinc metalloprotease
Tbon_RS12820	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tbon_RS12825	COG0439	Biotin carboxylase
Tbon_RS12830	COG5016	pyruvate
Tbon_RS12830	COG0511	ligase activity, forming carbon-carbon bonds
Tbon_RS12840	COG3583	domain protein
Tbon_RS12840	COG3584	3D domain protein
Tbon_RS12845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tbon_RS12850	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tbon_RS12885	COG0114	fumarate hydratase activity
Tbon_RS12895	COG0537	adenosine 5'-monophosphoramidase activity
Tbon_RS12905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tbon_RS12925	COG0489	protein tyrosine kinase activity
Tbon_RS12935	COG0167	dihydroorotate dehydrogenase activity
Tbon_RS12945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tbon_RS12950	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tbon_RS12955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tbon_RS12960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Tbon_RS12965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tbon_RS12975	COG0137	argininosuccinate synthase activity
Tbon_RS12985	COG0366	Alpha amylase catalytic
Tbon_RS12995	COG0495	leucyl-tRNA aminoacylation
Tbon_RS13020	COG0742	ribosomal rna small subunit methyltransferase
Tbon_RS13030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tbon_RS13035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tbon_RS13040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tbon_RS13050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tbon_RS13065	COG0045	succinate-CoA ligase (ADP-forming) activity
Tbon_RS13070	COG0740	serine-type endopeptidase activity
Tbon_RS13090	COG0778	Nitroreductase
Tbon_RS13100	COG4552	Acetyltransferase involved in intracellular survival and related
Tbon_RS13115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tbon_RS13120	COG0070	glutamate synthase
Tbon_RS13120	COG0069	glutamate synthase activity
Tbon_RS13120	COG0067	glutamate synthase
Tbon_RS13140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tbon_RS13145	COG2205	protein histidine kinase activity
Tbon_RS13150	COG0745	RESPONSE REGULATOR receiver
Tbon_RS13155	COG1830	Aldolase
Tbon_RS13160	COG0745	RESPONSE REGULATOR receiver
Tbon_RS13165	COG1191	sigma factor activity
Tbon_RS13175	COG0793	Belongs to the peptidase S41A family
Tbon_RS13175	COG3409	Peptidoglycan-binding domain 1 protein
Tbon_RS13180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tbon_RS13190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tbon_RS13205	COG2217	Heavy metal translocating P-type atpase
Tbon_RS13210	COG2217	Heavy metal translocating P-type atpase
Tbon_RS13220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS13230	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Tbon_RS13240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tbon_RS13250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tbon_RS13260	COG0358	DNA primase activity
Tbon_RS13275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS13280	COG0215	cysteine-tRNA ligase activity
Tbon_RS13305	COG1960	acyl-CoA dehydrogenase activity
Tbon_RS13310	COG1234	tRNA 3'-trailer cleavage
Tbon_RS13335	COG0577	efflux transmembrane transporter activity
Tbon_RS13335	COG1136	(ABC) transporter
Tbon_RS13340	COG1136	(ABC) transporter
Tbon_RS13340	COG0577	efflux transmembrane transporter activity
Tbon_RS13355	COG0018	arginyl-trna synthetase
Tbon_RS13375	COG1058	Belongs to the CinA family
Tbon_RS13375	COG1546	Belongs to the CinA family
Tbon_RS13385	COG0730	response to heat
Tbon_RS13415	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tbon_RS13440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS13450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tbon_RS13470	COG2046	Belongs to the sulfate adenylyltransferase family
Tbon_RS13470	COG0529	Catalyzes the synthesis of activated sulfate
Tbon_RS13475	COG0175	sulfate reduction
Tbon_RS13480	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tbon_RS13490	COG0113	porphobilinogen synthase activity
Tbon_RS13495	COG3383	formate dehydrogenase (NAD+) activity
Tbon_RS13500	COG3383	formate dehydrogenase (NAD+) activity
Tbon_RS13505	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tbon_RS13535	COG0788	formyltetrahydrofolate deformylase activity
Tbon_RS13540	COG4166	transmembrane transport
Tbon_RS13545	COG0601	transmembrane transport
Tbon_RS13550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tbon_RS13565	COG0785	Cytochrome C biogenesis protein
Tbon_RS13590	COG3226	Transcriptional regulator
Tbon_RS13600	COG0383	alpha-mannosidase activity
Tbon_RS13605	COG0728	peptidoglycan biosynthetic process
Tbon_RS13615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate