locus-tag	class	description
IGS63_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IGS63_RS00010	COG1063	alcohol dehydrogenase
IGS63_RS00015	COG0156	8-amino-7-oxononanoate synthase activity
IGS63_RS00020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IGS63_RS00035	COG1309	transcriptional regulator
IGS63_RS00050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IGS63_RS00055	COG0242	peptide deformylase activity
IGS63_RS00060	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IGS63_RS00070	COG0489	protein tyrosine kinase activity
IGS63_RS00080	COG2813	Specifically methylates the guanine in position
IGS63_RS00090	COG1122	ATPase activity
IGS63_RS00105	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IGS63_RS00110	COG2086	electron transfer activity
IGS63_RS00115	COG1960	acyl-CoA dehydrogenase activity
IGS63_RS00145	COG3328	transposase activity
IGS63_RS00170	COG0641	radical SAM
IGS63_RS00205	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IGS63_RS00235	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IGS63_RS00260	COG0084	hydrolase, TatD family'
IGS63_RS00265	COG0561	phosphatase activity
IGS63_RS00280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IGS63_RS00300	COG1131	(ABC) transporter
IGS63_RS00315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IGS63_RS00320	COG0191	fructose-bisphosphate aldolase activity
IGS63_RS00325	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGS63_RS00335	COG0534	Mate efflux family protein
IGS63_RS00340	COG4716	Myosin-crossreactive antigen
IGS63_RS00350	COG0697	spore germination
IGS63_RS00370	COG1278	Cold shock
IGS63_RS00375	COG1278	Cold shock
IGS63_RS00385	COG1706	bacterial-type flagellum-dependent cell motility
IGS63_RS00400	COG4786	Flagellar basal body rod
IGS63_RS00405	COG4786	Flagellar basal body rod
IGS63_RS00410	COG1077	Cell shape determining protein MreB Mrl
IGS63_RS00420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IGS63_RS00430	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IGS63_RS00430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IGS63_RS00435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IGS63_RS00445	COG0628	permease
IGS63_RS00460	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IGS63_RS00480	COG1131	(ABC) transporter
IGS63_RS00485	COG3437	response regulator, receiver
IGS63_RS00500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IGS63_RS00515	COG1802	Transcriptional regulator
IGS63_RS00520	COG1013	pyruvate-flavodoxin oxidoreductase activity
IGS63_RS00525	COG0674	pyruvate-flavodoxin oxidoreductase activity
IGS63_RS00530	COG1144	Oxidoreductase
IGS63_RS00570	COG1518	maintenance of DNA repeat elements
IGS63_RS00575	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IGS63_RS00585	COG0017	Asparaginyl-tRNA synthetase
IGS63_RS00590	COG0174	glutamine synthetase
IGS63_RS00595	COG0138	bifunctional purine biosynthesis protein purh
IGS63_RS00605	COG5002	protein histidine kinase activity
IGS63_RS00605	COG3447	MASE1 domain protein
IGS63_RS00605	COG5001	Diguanylate cyclase
IGS63_RS00615	COG1309	transcriptional regulator
IGS63_RS00625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS63_RS00630	COG4608	Belongs to the ABC transporter superfamily
IGS63_RS00635	COG0444	Belongs to the ABC transporter superfamily
IGS63_RS00640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS63_RS00645	COG0601	transmembrane transport
IGS63_RS00650	COG0747	negative chemotaxis
IGS63_RS00660	COG0564	pseudouridine synthase activity
IGS63_RS00675	COG0436	Aminotransferase
IGS63_RS00715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IGS63_RS00720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS63_RS00725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IGS63_RS00735	COG0402	S-adenosylhomocysteine deaminase activity
IGS63_RS00740	COG0167	dihydroorotate dehydrogenase activity
IGS63_RS00760	COG0733	neurotransmitter:sodium symporter activity
IGS63_RS00770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IGS63_RS00775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IGS63_RS00780	COG1862	Preprotein translocase
IGS63_RS00800	COG0574	Belongs to the PEP-utilizing enzyme family
IGS63_RS00800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IGS63_RS00805	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IGS63_RS00815	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IGS63_RS00815	COG0674	pyruvate-flavodoxin oxidoreductase activity
IGS63_RS00820	COG2199	diguanylate cyclase activity
IGS63_RS00820	COG2203	Gaf domain
IGS63_RS00825	COG2359	stage V sporulation protein S
IGS63_RS00835	COG3872	metal-dependent enzyme
IGS63_RS00840	COG3279	Response regulator of the LytR AlgR family
IGS63_RS00845	COG3275	phosphorelay sensor kinase activity
IGS63_RS00855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IGS63_RS00865	COG0758	DNA mediated transformation
IGS63_RS00865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IGS63_RS00880	COG1847	R3H domain protein
IGS63_RS00885	COG0706	membrane insertase activity
IGS63_RS00890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IGS63_RS00895	COG0594	ribonuclease P activity
IGS63_RS00900	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IGS63_RS00910	COG0737	Belongs to the 5'-nucleotidase family
IGS63_RS00920	COG0840	transmembrane signaling receptor activity
IGS63_RS00930	COG0840	transmembrane signaling receptor activity
IGS63_RS00950	COG0674	pyruvate-flavodoxin oxidoreductase activity
IGS63_RS00965	COG3426	butyrate kinase activity
IGS63_RS00970	COG0280	phosphate acetyltransferase
IGS63_RS00975	COG3426	butyrate kinase activity
IGS63_RS00980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS63_RS00985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGS63_RS00990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IGS63_RS01040	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS63_RS01050	COG1132	(ABC) transporter
IGS63_RS01070	COG3842	ATPase activity
IGS63_RS01080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IGS63_RS01085	COG0535	radical SAM domain protein
IGS63_RS01110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IGS63_RS01115	COG2205	protein histidine kinase activity
IGS63_RS01145	COG1758	RNA polymerase activity
IGS63_RS01150	COG0194	GDP metabolic process
IGS63_RS01155	COG2052	Domain of unknown function (DUF370)
IGS63_RS01160	COG1561	YicC-like family, N-terminal region
IGS63_RS01165	COG1104	cysteine desulfurase activity
IGS63_RS01170	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IGS63_RS01175	COG0509	glycine decarboxylation via glycine cleavage system
IGS63_RS01185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS63_RS01185	COG0072	phenylalanine-tRNA ligase activity
IGS63_RS01190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IGS63_RS01210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IGS63_RS01215	COG0488	(ABC) transporter
IGS63_RS01225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGS63_RS01260	COG1136	(ABC) transporter
IGS63_RS01265	COG5002	protein histidine kinase activity
IGS63_RS01270	COG0745	RESPONSE REGULATOR receiver
IGS63_RS01275	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS63_RS01280	COG0542	response to heat
IGS63_RS01285	COG3864	Putative metallopeptidase domain
IGS63_RS01295	COG1136	(ABC) transporter
IGS63_RS01305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IGS63_RS01310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IGS63_RS01315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IGS63_RS01320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IGS63_RS01325	COG2199	diguanylate cyclase activity
IGS63_RS01325	COG2203	Gaf domain
IGS63_RS01330	COG0653	protein targeting
IGS63_RS01340	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IGS63_RS01350	COG1376	ErfK ybiS ycfS ynhG family protein
IGS63_RS01355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IGS63_RS01360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IGS63_RS01370	COG1137	ATPase activity
IGS63_RS01385	COG1543	Belongs to the glycosyl hydrolase 57 family
IGS63_RS01390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IGS63_RS01395	COG1144	Oxidoreductase
IGS63_RS01400	COG0674	pyruvate-flavodoxin oxidoreductase activity
IGS63_RS01405	COG1013	pyruvate-flavodoxin oxidoreductase activity
IGS63_RS01410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IGS63_RS01420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IGS63_RS01425	COG3328	transposase activity
IGS63_RS01430	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IGS63_RS01435	COG2205	protein histidine kinase activity
IGS63_RS01445	COG0432	Pfam Uncharacterised protein family UPF0047
IGS63_RS01455	COG2894	cell division
IGS63_RS01470	COG1131	(ABC) transporter
IGS63_RS01480	COG3706	GGDEF domain
IGS63_RS01540	COG0343	queuine tRNA-ribosyltransferase activity
IGS63_RS01590	COG0438	transferase activity, transferring glycosyl groups
IGS63_RS01620	COG0438	transferase activity, transferring glycosyl groups
IGS63_RS01630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IGS63_RS01640	COG0776	regulation of translation
IGS63_RS01660	COG0840	transmembrane signaling receptor activity
IGS63_RS01675	COG1307	EDD domain protein, DegV family
IGS63_RS01680	COG3341	Caulimovirus viroplasmin
IGS63_RS01680	COG0328	RNA-DNA hybrid ribonuclease activity
IGS63_RS01690	COG0534	Mate efflux family protein
IGS63_RS01695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IGS63_RS01700	COG1272	protein, Hemolysin III
IGS63_RS01705	COG0071	Belongs to the small heat shock protein (HSP20) family
IGS63_RS01710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IGS63_RS01720	COG0281	malic enzyme
IGS63_RS01725	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IGS63_RS01725	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IGS63_RS01760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IGS63_RS01765	COG1215	transferase activity, transferring glycosyl groups
IGS63_RS01775	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IGS63_RS01780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS63_RS01790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IGS63_RS01800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS63_RS01805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS63_RS01810	COG1216	Glycosyl transferase, family 2
IGS63_RS01810	COG0463	Glycosyl transferase, family 2
IGS63_RS01820	COG0463	Glycosyl transferase, family 2
IGS63_RS01860	COG1215	transferase activity, transferring glycosyl groups
IGS63_RS01870	COG1088	dTDP-glucose 4,6-dehydratase activity
IGS63_RS01915	COG3404	Formiminotransferase-cyclodeaminase
IGS63_RS01930	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IGS63_RS01945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IGS63_RS01955	COG5012	cobalamin binding
IGS63_RS01975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IGS63_RS01980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGS63_RS01990	COG0779	Required for maturation of 30S ribosomal subunits
IGS63_RS01995	COG0195	Participates in both transcription termination and antitermination
IGS63_RS02010	COG0708	Exodeoxyribonuclease III
IGS63_RS02015	COG1966	Carbon starvation protein
IGS63_RS02045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IGS63_RS02050	COG3842	ATPase activity
IGS63_RS02055	COG0546	phosphoglycolate phosphatase activity
IGS63_RS02060	COG0513	Belongs to the DEAD box helicase family
IGS63_RS02080	COG0646	methionine synthase
IGS63_RS02080	COG1410	methionine synthase
IGS63_RS02105	COG0527	aspartate kinase activity
IGS63_RS02110	COG2310	stress, protein
IGS63_RS02115	COG2310	stress, protein
IGS63_RS02120	COG0530	calcium, potassium:sodium antiporter activity
IGS63_RS02125	COG2310	stress, protein
IGS63_RS02135	COG3853	Toxic anion resistance protein (TelA)
IGS63_RS02145	COG3437	response regulator, receiver
IGS63_RS02145	COG0784	Response regulator, receiver
IGS63_RS02150	COG0006	proline dipeptidase activity
IGS63_RS02155	COG1074	ATP-dependent DNA helicase activity
IGS63_RS02165	COG1406	Chemotaxis phosphatase CheX
IGS63_RS02170	COG0549	Belongs to the carbamate kinase family
IGS63_RS02175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IGS63_RS02180	COG2235	arginine
IGS63_RS02185	COG2379	hydroxypyruvate reductase
IGS63_RS02210	COG0395	ABC-type sugar transport system, permease component
IGS63_RS02215	COG1175	transmembrane transport
IGS63_RS02225	COG0438	transferase activity, transferring glycosyl groups
IGS63_RS02255	COG0745	RESPONSE REGULATOR receiver
IGS63_RS02260	COG3850	Histidine kinase
IGS63_RS02260	COG5002	protein histidine kinase activity
IGS63_RS02265	COG1363	Peptidase, m42
IGS63_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
IGS63_RS02305	COG1406	Chemotaxis phosphatase CheX
IGS63_RS02310	COG2226	methyltransferase
IGS63_RS02315	COG0306	phosphate transporter
IGS63_RS02320	COG1392	Phosphate transport regulator
IGS63_RS02325	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IGS63_RS02340	COG3681	Belongs to the UPF0597 family
IGS63_RS02370	COG0792	nuclease activity
IGS63_RS02375	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IGS63_RS02405	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
IGS63_RS02420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IGS63_RS02425	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IGS63_RS02430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IGS63_RS02435	COG3437	response regulator, receiver
IGS63_RS02440	COG0840	transmembrane signaling receptor activity
IGS63_RS02450	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS63_RS02450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IGS63_RS02460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS63_RS02465	COG1012	belongs to the aldehyde dehydrogenase family
IGS63_RS02470	COG1132	(ABC) transporter
IGS63_RS02475	COG1132	(ABC) transporter
IGS63_RS02505	COG0215	cysteine-tRNA ligase activity
IGS63_RS02510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IGS63_RS02530	COG4536	flavin adenine dinucleotide binding
IGS63_RS02535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IGS63_RS02540	COG0484	heat shock protein binding
IGS63_RS02545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IGS63_RS02550	COG1420	regulation of RNA biosynthetic process
IGS63_RS02555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IGS63_RS02560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IGS63_RS02565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGS63_RS02570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IGS63_RS02575	COG0772	Belongs to the SEDS family
IGS63_RS02580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IGS63_RS02585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IGS63_RS02590	COG3328	transposase activity
IGS63_RS02650	COG1355	regulation of microtubule-based process
IGS63_RS02660	COG1461	Dihydroxyacetone kinase
IGS63_RS02665	COG0752	glycyl-tRNA synthetase alpha subunit
IGS63_RS02685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IGS63_RS02690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IGS63_RS02695	COG0840	transmembrane signaling receptor activity
IGS63_RS02695	COG5278	phosphoserine phosphatase activity
IGS63_RS02700	COG1051	belongs to the nudix hydrolase family
IGS63_RS02720	COG3328	transposase activity
IGS63_RS02725	COG3328	transposase activity
IGS63_RS02770	COG1811	Na channel or pump
IGS63_RS02775	COG2195	Cleaves the N-terminal amino acid of tripeptides
IGS63_RS02785	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS63_RS02795	COG3328	transposase activity
IGS63_RS02810	COG1285	pathogenesis
IGS63_RS02815	COG0183	Belongs to the thiolase family
IGS63_RS02820	COG1028	Short-chain dehydrogenase reductase Sdr
IGS63_RS02825	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS63_RS02830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IGS63_RS02835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IGS63_RS02845	COG2030	dehydratase
IGS63_RS02855	COG0604	alcohol dehydrogenase
IGS63_RS02860	COG3246	L-lysine catabolic process to acetate
IGS63_RS02865	COG1607	acyl-coa hydrolase
IGS63_RS02875	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IGS63_RS02880	COG0393	Putative heavy-metal-binding
IGS63_RS02895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IGS63_RS02900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IGS63_RS02905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IGS63_RS02910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IGS63_RS02920	COG1660	Displays ATPase and GTPase activities
IGS63_RS02925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IGS63_RS02945	COG2359	stage V sporulation protein S
IGS63_RS02965	COG4786	Flagellar basal body rod
IGS63_RS02965	COG1256	bacterial-type flagellum assembly
IGS63_RS02965	COG4786	Flagellar basal body rod
IGS63_RS02965	COG1256	bacterial-type flagellum assembly
IGS63_RS02970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IGS63_RS02980	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IGS63_RS02995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IGS63_RS03000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IGS63_RS03005	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IGS63_RS03010	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IGS63_RS03015	COG2137	regulation of response to DNA damage stimulus
IGS63_RS03020	COG1193	negative regulation of DNA recombination
IGS63_RS03020	COG1418	mRNA catabolic process
IGS63_RS03045	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IGS63_RS03050	COG1160	GTP binding
IGS63_RS03055	COG0539	negative regulation of cytoplasmic translation
IGS63_RS03060	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IGS63_RS03065	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IGS63_RS03070	COG1366	Belongs to the anti-sigma-factor antagonist family
IGS63_RS03075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IGS63_RS03085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IGS63_RS03095	COG2205	protein histidine kinase activity
IGS63_RS03095	COG3437	response regulator, receiver
IGS63_RS03095	COG3850	Histidine kinase
IGS63_RS03095	COG4999	Histidine kinase
IGS63_RS03100	COG0193	aminoacyl-tRNA hydrolase activity
IGS63_RS03105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IGS63_RS03110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IGS63_RS03115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IGS63_RS03120	COG0632	four-way junction helicase activity
IGS63_RS03125	COG0285	dihydrofolate synthase activity
IGS63_RS03130	COG0525	valine-tRNA ligase activity
IGS63_RS03145	COG2205	protein histidine kinase activity
IGS63_RS03145	COG3850	Histidine kinase
IGS63_RS03145	COG3437	response regulator, receiver
IGS63_RS03145	COG4999	Histidine kinase
IGS63_RS03160	COG1757	Na H antiporter
IGS63_RS03175	COG4555	ABC transporter
IGS63_RS03185	COG2045	Belongs to the ComB family
IGS63_RS03205	COG3279	Response regulator of the LytR AlgR family
IGS63_RS03210	COG3833	ABC-type maltose transport systems, permease component
IGS63_RS03215	COG1175	transmembrane transport
IGS63_RS03220	COG2182	Extracellular solute-binding protein
IGS63_RS03225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IGS63_RS03230	COG1215	transferase activity, transferring glycosyl groups
IGS63_RS03235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IGS63_RS03240	COG0728	peptidoglycan biosynthetic process
IGS63_RS03250	COG3328	transposase activity
IGS63_RS03255	COG3328	transposase activity
IGS63_RS03265	COG3328	transposase activity
IGS63_RS03295	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IGS63_RS03295	COG0662	Cupin 2, conserved barrel domain protein
IGS63_RS03300	COG1482	cell wall glycoprotein biosynthetic process
IGS63_RS03315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IGS63_RS03330	COG0822	iron-sulfur transferase activity
IGS63_RS03335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IGS63_RS03340	COG0719	Fe-S assembly protein
IGS63_RS03345	COG0719	Fe-S assembly protein
IGS63_RS03350	COG0396	ATPase activity
IGS63_RS03365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS63_RS03370	COG1307	EDD domain protein, DegV family
IGS63_RS03375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IGS63_RS03380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS63_RS03390	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IGS63_RS03420	COG0542	response to heat
IGS63_RS03435	COG2985	domain, Protein
IGS63_RS03435	COG0569	domain protein
IGS63_RS03445	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IGS63_RS03445	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IGS63_RS03450	COG1435	thymidine kinase activity
IGS63_RS03470	COG4443	Transcriptional Coactivator p15 (PC4)
IGS63_RS03485	COG1516	flagellar protein fliS
IGS63_RS03500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGS63_RS03505	COG1086	Polysaccharide biosynthesis protein
IGS63_RS03510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IGS63_RS03520	COG0124	histidyl-tRNA synthetase
IGS63_RS03525	COG1185	polyribonucleotide nucleotidyltransferase activity
IGS63_RS03530	COG0254	rRNA binding
IGS63_RS03545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IGS63_RS03550	COG1584	GPR1 FUN34 yaaH family protein
IGS63_RS03580	COG0477	Major facilitator Superfamily
IGS63_RS03585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IGS63_RS03590	COG0166	Belongs to the GPI family
IGS63_RS03595	COG0237	dephospho-CoA kinase activity
IGS63_RS03610	COG0322	excinuclease ABC activity
IGS63_RS03620	COG2264	protein methyltransferase activity
IGS63_RS03635	COG3337	CRISPR-associated protein (Cas_Cmr5)
IGS63_RS03665	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IGS63_RS03670	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IGS63_RS03705	COG1937	Protein conserved in bacteria
IGS63_RS03710	COG0793	Belongs to the peptidase S41A family
IGS63_RS03750	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IGS63_RS03760	COG0640	Transcriptional regulator
IGS63_RS03790	COG2081	HI0933 family
IGS63_RS03795	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IGS63_RS03800	COG2195	Cleaves the N-terminal amino acid of tripeptides
IGS63_RS03810	COG1358	cellular component organization or biogenesis
IGS63_RS03830	COG0540	Belongs to the ATCase OTCase family
IGS63_RS03830	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IGS63_RS03840	COG2080	2 iron, 2 sulfur cluster binding
IGS63_RS03845	COG2080	2 iron, 2 sulfur cluster binding
IGS63_RS03845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS63_RS03850	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IGS63_RS03860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IGS63_RS03880	COG1979	alcohol dehydrogenase
IGS63_RS03900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IGS63_RS03910	COG0028	Belongs to the TPP enzyme family
IGS63_RS03930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IGS63_RS03935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IGS63_RS03940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IGS63_RS03945	COG0463	Glycosyl transferase, family 2
IGS63_RS03945	COG0457	Tetratricopeptide repeat
IGS63_RS03950	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IGS63_RS03985	COG0101	tRNA pseudouridine synthase activity
IGS63_RS04000	COG2226	methyltransferase
IGS63_RS04025	COG1530	ribonuclease E activity
IGS63_RS04030	COG3706	GGDEF domain
IGS63_RS04040	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IGS63_RS04045	COG0233	cytoplasmic translational termination
IGS63_RS04050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IGS63_RS04055	COG0575	Belongs to the CDS family
IGS63_RS04065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IGS63_RS04090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS63_RS04095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS63_RS04105	COG1085	galactose-1-phosphate uridylyltransferase
IGS63_RS04110	COG0297	glycogen (starch) synthase activity
IGS63_RS04130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IGS63_RS04135	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IGS63_RS04165	COG1131	(ABC) transporter
IGS63_RS04190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IGS63_RS04195	COG0228	four-way junction DNA binding
IGS63_RS04200	COG1837	Belongs to the UPF0109 family
IGS63_RS04205	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IGS63_RS04210	COG0336	Belongs to the RNA methyltransferase TrmD family
IGS63_RS04215	COG4752	Belongs to the RNA methyltransferase TrmD family
IGS63_RS04220	COG0335	large ribosomal subunit rRNA binding
IGS63_RS04225	COG0681	Belongs to the peptidase S26 family
IGS63_RS04235	COG0357	Ribosomal RNA small subunit methyltransferase G
IGS63_RS04240	COG0095	Lipoate-protein ligase
IGS63_RS04245	COG0019	diaminopimelate decarboxylase activity
IGS63_RS04255	COG3290	protein histidine kinase activity
IGS63_RS04255	COG0840	transmembrane signaling receptor activity
IGS63_RS04260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IGS63_RS04265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS63_RS04275	COG3852	Histidine kinase
IGS63_RS04280	COG2204	response regulator
IGS63_RS04285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IGS63_RS04295	COG0776	regulation of translation
IGS63_RS04300	COG0835	chemotaxis
IGS63_RS04315	COG1940	carbohydrate kinase activity
IGS63_RS04320	COG0840	transmembrane signaling receptor activity
IGS63_RS04360	COG0534	Mate efflux family protein
IGS63_RS04365	COG1846	Transcriptional regulator
IGS63_RS04380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IGS63_RS04385	COG0459	protein refolding
IGS63_RS04390	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IGS63_RS04395	COG0840	transmembrane signaling receptor activity
IGS63_RS04405	COG0280	phosphate acetyltransferase
IGS63_RS04435	COG0737	Belongs to the 5'-nucleotidase family
IGS63_RS04480	COG1653	transport
IGS63_RS04485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS63_RS04490	COG0438	transferase activity, transferring glycosyl groups
IGS63_RS04545	COG1136	(ABC) transporter
IGS63_RS04555	COG1141	Ferredoxin
IGS63_RS04560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGS63_RS04565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IGS63_RS04600	COG0579	oxidoreductase
IGS63_RS04605	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IGS63_RS04620	COG2094	Belongs to the DNA glycosylase MPG family
IGS63_RS04625	COG0606	chelatase, subunit chli
IGS63_RS04645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS63_RS04650	COG0617	tRNA 3'-terminal CCA addition
IGS63_RS04650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IGS63_RS04650	COG3620	sequence-specific DNA binding
IGS63_RS04660	COG0366	Alpha amylase catalytic
IGS63_RS04680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS63_RS04685	COG0504	CTP synthase activity
IGS63_RS04710	COG1595	DNA-templated transcription, initiation
IGS63_RS04720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IGS63_RS04775	COG5002	protein histidine kinase activity
IGS63_RS04775	COG5001	Diguanylate cyclase
IGS63_RS04775	COG3447	MASE1 domain protein
IGS63_RS04790	COG0785	Cytochrome C biogenesis protein
IGS63_RS04815	COG0484	heat shock protein binding
IGS63_RS04825	COG1164	Oligoendopeptidase f
IGS63_RS04830	COG2252	PERMEase
IGS63_RS04835	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IGS63_RS04910	COG1805	sodium ion transport
IGS63_RS04915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGS63_RS04925	COG1492	cobalamin metabolic process
IGS63_RS04940	COG1121	(ABC) transporter
IGS63_RS04945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IGS63_RS04950	COG4869	propanediol catabolic process
IGS63_RS04955	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IGS63_RS04960	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IGS63_RS04970	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IGS63_RS04975	COG1418	mRNA catabolic process
IGS63_RS04990	COG4106	trans-aconitate 2-methyltransferase activity
IGS63_RS05005	COG0495	leucyl-tRNA aminoacylation
IGS63_RS05010	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IGS63_RS05025	COG2431	L-lysine efflux transmembrane transporter activity
IGS63_RS05045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IGS63_RS05055	COG1027	Aspartate ammonia-lyase
IGS63_RS05060	COG0840	transmembrane signaling receptor activity
IGS63_RS05065	COG1609	Transcriptional regulator
IGS63_RS05070	COG1129	ABC transporter
IGS63_RS05095	COG0745	RESPONSE REGULATOR receiver
IGS63_RS05100	COG2770	Histidine kinase
IGS63_RS05100	COG2205	protein histidine kinase activity
IGS63_RS05105	COG1473	amidohydrolase
IGS63_RS05110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IGS63_RS05120	COG2171	N-acyltransferase activity
IGS63_RS05125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IGS63_RS05130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS63_RS05140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IGS63_RS05150	COG1937	Protein conserved in bacteria
IGS63_RS05155	COG2217	Heavy metal translocating P-type atpase
IGS63_RS05165	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IGS63_RS05170	COG3706	GGDEF domain
IGS63_RS05180	COG0587	DNA-directed DNA polymerase activity
IGS63_RS05185	COG0564	pseudouridine synthase activity
IGS63_RS05195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IGS63_RS05205	COG0217	transcriptional regulatory protein
IGS63_RS05210	COG2208	phosphoserine phosphatase activity
IGS63_RS05215	COG2201	protein-glutamate methylesterase activity
IGS63_RS05225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS63_RS05240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IGS63_RS05250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IGS63_RS05255	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IGS63_RS05260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IGS63_RS05265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IGS63_RS05270	COG0358	DNA primase activity
IGS63_RS05275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IGS63_RS05285	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IGS63_RS05290	COG0049	tRNA binding
IGS63_RS05295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IGS63_RS05300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IGS63_RS05305	COG0051	transcription antitermination factor activity, RNA binding
IGS63_RS05310	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IGS63_RS05315	COG0088	Forms part of the polypeptide exit tunnel
IGS63_RS05320	COG0089	rRNA binding
IGS63_RS05325	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IGS63_RS05330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IGS63_RS05335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IGS63_RS05340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IGS63_RS05345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IGS63_RS05350	COG0255	Belongs to the universal ribosomal protein uL29 family
IGS63_RS05355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IGS63_RS05360	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IGS63_RS05365	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IGS63_RS05370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IGS63_RS05375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IGS63_RS05380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IGS63_RS05385	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IGS63_RS05390	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IGS63_RS05395	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IGS63_RS05400	COG1841	ribosomal large subunit assembly
IGS63_RS05405	COG0200	Binds to the 23S rRNA
IGS63_RS05410	COG0201	protein transport
IGS63_RS05415	COG0563	adenylate kinase activity
IGS63_RS05425	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IGS63_RS05430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IGS63_RS05435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IGS63_RS05440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IGS63_RS05445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IGS63_RS05450	COG0202	RNA polymerase activity
IGS63_RS05455	COG0203	ribosomal protein L17
IGS63_RS05460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IGS63_RS05465	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IGS63_RS05475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IGS63_RS05485	COG1242	4 iron, 4 sulfur cluster binding
IGS63_RS05495	COG0402	S-adenosylhomocysteine deaminase activity
IGS63_RS05500	COG0235	Class ii aldolase
IGS63_RS05530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IGS63_RS05535	COG0052	Belongs to the universal ribosomal protein uS2 family
IGS63_RS05540	COG0799	negative regulation of ribosome biogenesis
IGS63_RS05545	COG0416	fatty acid biosynthetic process
IGS63_RS05550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IGS63_RS05570	COG0006	proline dipeptidase activity
IGS63_RS05580	COG1307	EDD domain protein, DegV family
IGS63_RS05600	COG1863	multisubunit Na H antiporter MnhE subunit
IGS63_RS05605	COG2212	antiporter activity
IGS63_RS05620	COG2111	Na H antiporter
IGS63_RS05625	COG1006	Multisubunit Na H antiporter MnhC subunit
IGS63_RS05630	COG0651	ATP synthesis coupled electron transport
IGS63_RS05640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IGS63_RS05645	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS63_RS05650	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS63_RS05655	COG0649	NAD binding
IGS63_RS05675	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IGS63_RS05705	COG0534	Mate efflux family protein
IGS63_RS05710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IGS63_RS05735	COG0588	phosphoglycerate mutase activity
IGS63_RS05755	COG0196	riboflavin kinase activity
IGS63_RS05760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IGS63_RS05765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IGS63_RS05775	COG5002	protein histidine kinase activity
IGS63_RS05785	COG2239	Acts as a magnesium transporter
IGS63_RS05790	COG2270	Major facilitator Superfamily
IGS63_RS05800	COG1677	Flagellar hook-basal body complex protein FliE
IGS63_RS05835	COG1744	ABC transporter substrate-binding protein PnrA-like
IGS63_RS05840	COG3845	ABC transporter
IGS63_RS05845	COG4603	Belongs to the binding-protein-dependent transport system permease family
IGS63_RS05850	COG1079	Belongs to the binding-protein-dependent transport system permease family
IGS63_RS05855	COG0667	Aldo Keto reductase
IGS63_RS05860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IGS63_RS05865	COG3956	TIGRFAM MazG family protein
IGS63_RS05880	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS63_RS05885	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IGS63_RS05890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IGS63_RS05895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IGS63_RS05900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IGS63_RS05910	COG0512	Glutamine amidotransferase of anthranilate synthase
IGS63_RS05910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IGS63_RS05915	COG0134	indole-3-glycerol-phosphate synthase activity
IGS63_RS05920	COG0133	tryptophan synthase activity
IGS63_RS05925	COG0159	tryptophan synthase activity
IGS63_RS05930	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS63_RS05950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGS63_RS05960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IGS63_RS05965	COG4112	unkown
IGS63_RS05970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IGS63_RS05975	COG1181	Belongs to the D-alanine--D-alanine ligase family
IGS63_RS05980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IGS63_RS05985	COG3481	metal-dependent phosphohydrolase, HD sub domain
IGS63_RS05990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IGS63_RS06000	COG0312	modulator of DNA gyrase
IGS63_RS06005	COG0312	modulator of DNA gyrase
IGS63_RS06030	COG3328	transposase activity
IGS63_RS06040	COG3328	transposase activity
IGS63_RS06060	COG1132	(ABC) transporter
IGS63_RS06065	COG1132	(ABC) transporter
IGS63_RS06075	COG3300	MHYT domain
IGS63_RS06075	COG5001	Diguanylate cyclase
IGS63_RS06105	COG1968	undecaprenyl-diphosphatase activity
IGS63_RS06110	COG0671	phosphoesterase, PA-phosphatase related
IGS63_RS06120	COG0534	Mate efflux family protein
IGS63_RS06135	COG0366	Alpha amylase catalytic
IGS63_RS06140	COG0488	(ABC) transporter
IGS63_RS06145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IGS63_RS06150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS63_RS06155	COG1120	ATPase activity
IGS63_RS06170	COG0180	Tryptophanyl-tRNA synthetase
IGS63_RS06185	COG1187	pseudouridine synthase activity
IGS63_RS06195	COG2252	PERMEase
IGS63_RS06205	COG1058	Belongs to the CinA family
IGS63_RS06205	COG1546	Belongs to the CinA family
IGS63_RS06250	COG1528	Iron-storage protein
IGS63_RS06265	COG2738	Putative neutral zinc metallopeptidase
IGS63_RS06270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IGS63_RS06270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IGS63_RS06275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IGS63_RS06285	COG1162	GTPase activity
IGS63_RS06290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IGS63_RS06295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IGS63_RS06300	COG0004	ammonium transporteR
IGS63_RS06310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IGS63_RS06335	COG1196	nuclear chromosome segregation
IGS63_RS06340	COG1573	uracil-dna glycosylase
IGS63_RS06355	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IGS63_RS06365	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IGS63_RS06370	COG2255	four-way junction helicase activity
IGS63_RS06375	COG0017	Asparaginyl-tRNA synthetase
IGS63_RS06390	COG0037	tRNA processing
IGS63_RS06395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IGS63_RS06405	COG0745	RESPONSE REGULATOR receiver
IGS63_RS06410	COG5002	protein histidine kinase activity
IGS63_RS06415	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IGS63_RS06425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IGS63_RS06435	COG0697	spore germination
IGS63_RS06445	COG2176	DNA-directed DNA polymerase activity
IGS63_RS06450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IGS63_RS06455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS63_RS06485	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IGS63_RS06515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IGS63_RS06520	COG0629	single-stranded DNA binding
IGS63_RS06525	COG0360	Binds together with S18 to 16S ribosomal RNA
IGS63_RS06530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IGS63_RS06545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IGS63_RS06555	COG0511	ligase activity, forming carbon-carbon bonds
IGS63_RS06570	COG0346	lactoylglutathione lyase activity
IGS63_RS06580	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS63_RS06580	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS63_RS06585	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS63_RS06585	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IGS63_RS06625	COG0411	ABC transporter
IGS63_RS06635	COG0559	Belongs to the binding-protein-dependent transport system permease family
IGS63_RS06645	COG0157	Belongs to the NadC ModD family
IGS63_RS06650	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IGS63_RS06655	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IGS63_RS06660	COG1592	Rubrerythrin
IGS63_RS06665	COG0443	Heat shock 70 kDa protein
IGS63_RS06680	COG0445	tRNA wobble uridine modification
IGS63_RS06775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IGS63_RS06780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IGS63_RS06780	COG0731	radical SAM domain protein
IGS63_RS06800	COG1067	ATP-dependent peptidase activity
IGS63_RS06805	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IGS63_RS06810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS63_RS06810	COG4191	Histidine kinase
IGS63_RS06815	COG3437	response regulator, receiver
IGS63_RS06815	COG0784	Response regulator, receiver
IGS63_RS06820	COG0784	Response regulator, receiver
IGS63_RS06820	COG3437	response regulator, receiver
IGS63_RS06840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IGS63_RS06845	COG0154	amidase activity
IGS63_RS06850	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IGS63_RS06900	COG4989	oxidoreductase activity
IGS63_RS06905	COG1671	Belongs to the UPF0178 family
IGS63_RS06915	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IGS63_RS06920	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IGS63_RS06925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IGS63_RS06930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IGS63_RS06935	COG0047	phosphoribosylformylglycinamidine synthase activity
IGS63_RS06950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IGS63_RS06960	COG0277	FAD linked oxidase domain protein
IGS63_RS06965	COG1070	Carbohydrate kinase
IGS63_RS06975	COG0492	ferredoxin-NADP+ reductase activity
IGS63_RS06985	COG2188	Transcriptional regulator
IGS63_RS07005	COG3852	Histidine kinase
IGS63_RS07030	COG3328	transposase activity
IGS63_RS07055	COG0151	Belongs to the GarS family
IGS63_RS07080	COG0426	domain, Protein
IGS63_RS07090	COG2033	superoxide reductase activity
IGS63_RS07095	COG1592	Rubrerythrin
IGS63_RS07100	COG0300	oxidoreductase activity
IGS63_RS07105	COG1653	transport
IGS63_RS07110	COG1175	transmembrane transport
IGS63_RS07120	COG0419	ATPase involved in DNA repair
IGS63_RS07125	COG0420	3'-5' exonuclease activity
IGS63_RS07130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IGS63_RS07135	COG0402	S-adenosylhomocysteine deaminase activity
IGS63_RS07160	COG0826	peptidase U32
IGS63_RS07180	COG0719	Fe-S assembly protein
IGS63_RS07185	COG1122	ATPase activity
IGS63_RS07190	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IGS63_RS07195	COG0772	Belongs to the SEDS family
IGS63_RS07210	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IGS63_RS07210	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IGS63_RS07215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IGS63_RS07220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IGS63_RS07230	COG1766	The M ring may be actively involved in energy transduction
IGS63_RS07235	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IGS63_RS07245	COG1157	protein secretion by the type III secretion system
IGS63_RS07255	COG0395	ABC-type sugar transport system, permease component
IGS63_RS07265	COG2521	methyltransferase
IGS63_RS07265	COG2136	Putative SAM-dependent methyltransferase
IGS63_RS07270	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IGS63_RS07275	COG1923	regulation of RNA biosynthetic process
IGS63_RS07285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IGS63_RS07295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IGS63_RS07300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IGS63_RS07310	COG1827	regulation of RNA biosynthetic process
IGS63_RS07315	COG2271	Major facilitator Superfamily
IGS63_RS07320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IGS63_RS07325	COG0643	Histidine kinase
IGS63_RS07325	COG2198	Histidine kinase
IGS63_RS07330	COG2201	protein-glutamate methylesterase activity
IGS63_RS07340	COG1338	Plays a role in the flagellum-specific transport system
IGS63_RS07345	COG1987	bacterial-type flagellum assembly
IGS63_RS07350	COG1684	flagellar biosynthetic protein fliR
IGS63_RS07355	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IGS63_RS07360	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IGS63_RS07365	COG1419	protein localization to endoplasmic reticulum
IGS63_RS07385	COG1776	CheC inhibitor of MCP methylation
IGS63_RS07390	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IGS63_RS07395	COG1191	sigma factor activity
IGS63_RS07415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IGS63_RS07420	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IGS63_RS07440	COG2204	response regulator
IGS63_RS07445	COG1739	Uncharacterized protein family UPF0029
IGS63_RS07450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IGS63_RS07465	COG0300	oxidoreductase activity
IGS63_RS07475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGS63_RS07480	COG1496	oxidoreductase activity
IGS63_RS07485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS63_RS07490	COG2183	response to ionizing radiation
IGS63_RS07495	COG0519	Catalyzes the synthesis of GMP from XMP
IGS63_RS07495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IGS63_RS07520	COG0402	S-adenosylhomocysteine deaminase activity
IGS63_RS07535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IGS63_RS07555	COG1268	BioY protein
IGS63_RS07565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IGS63_RS07575	COG0613	PHP domain protein
IGS63_RS07580	COG0584	glycerophosphoryl diester phosphodiesterase
IGS63_RS07590	COG0305	Participates in initiation and elongation during chromosome replication
IGS63_RS07595	COG0557	exoribonuclease II activity
IGS63_RS07600	COG0359	binds to the 23S rRNA
IGS63_RS07605	COG1234	tRNA 3'-trailer cleavage
IGS63_RS07635	COG0517	IMP dehydrogenase activity
IGS63_RS07635	COG0516	GMP reductase activity
IGS63_RS07640	COG1323	Belongs to the UPF0348 family
IGS63_RS07645	COG0012	GTP binding
IGS63_RS07660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IGS63_RS07665	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IGS63_RS07670	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IGS63_RS07680	COG0205	6-phosphofructokinase activity
IGS63_RS07685	COG0469	pyruvate kinase activity
IGS63_RS07690	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IGS63_RS07710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IGS63_RS07720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IGS63_RS07725	COG1490	D-aminoacyl-tRNA deacylase activity
IGS63_RS07740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IGS63_RS07760	COG2199	diguanylate cyclase activity
IGS63_RS07760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IGS63_RS07770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IGS63_RS07775	COG0750	zinc metalloprotease
IGS63_RS07780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IGS63_RS07790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IGS63_RS07795	COG1774	PSP1 C-terminal conserved region
IGS63_RS07805	COG0571	ribonuclease III activity
IGS63_RS07820	COG3829	transcription factor binding
IGS63_RS07820	COG3290	protein histidine kinase activity
IGS63_RS07840	COG0174	glutamine synthetase
IGS63_RS07845	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IGS63_RS07850	COG2342	PFAM TM1410 hypothetical-related protein
IGS63_RS07855	COG0009	L-threonylcarbamoyladenylate synthase
IGS63_RS07860	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IGS63_RS07865	COG1032	radical SAM domain protein
IGS63_RS07885	COG3842	ATPase activity
IGS63_RS07895	COG0205	6-phosphofructokinase activity
IGS63_RS07900	COG2027	D-alanyl-D-alanine carboxypeptidase
IGS63_RS07905	COG0116	Belongs to the methyltransferase superfamily
IGS63_RS07915	COG3437	response regulator, receiver
IGS63_RS07925	COG2022	thiamine diphosphate biosynthetic process
IGS63_RS07930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IGS63_RS07935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IGS63_RS07940	COG0351	phosphomethylpyrimidine kinase
IGS63_RS07940	COG1992	Thiamine-phosphate synthase
IGS63_RS07980	COG1918	ferrous iron import across plasma membrane
IGS63_RS07980	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IGS63_RS08020	COG0582	viral genome integration into host DNA
IGS63_RS08030	COG2313	pseudouridylate synthase activity
IGS63_RS08035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS63_RS08040	COG0583	DNA-binding transcription factor activity
IGS63_RS08045	COG4716	Myosin-crossreactive antigen
IGS63_RS08070	COG0626	cystathionine gamma-synthase activity
IGS63_RS08075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IGS63_RS08085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS63_RS08115	COG0425	Belongs to the sulfur carrier protein TusA family
IGS63_RS08120	COG2391	methyltransferase activity
IGS63_RS08145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGS63_RS08150	COG0509	glycine decarboxylation via glycine cleavage system
IGS63_RS08155	COG0167	dihydroorotate dehydrogenase activity
IGS63_RS08155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IGS63_RS08165	COG0640	Transcriptional regulator
IGS63_RS08190	COG1131	(ABC) transporter
IGS63_RS08205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IGS63_RS08235	COG0493	'glutamate synthase
IGS63_RS08235	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IGS63_RS08240	COG1362	aminopeptidase activity
IGS63_RS08245	COG1363	Peptidase, m42
IGS63_RS08250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IGS63_RS08255	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IGS63_RS08295	COG0406	alpha-ribazole phosphatase activity
IGS63_RS08305	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IGS63_RS08315	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
IGS63_RS08330	COG0747	negative chemotaxis
IGS63_RS08335	COG0601	transmembrane transport
IGS63_RS08340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS63_RS08350	COG0444	Belongs to the ABC transporter superfamily
IGS63_RS08355	COG4608	Belongs to the ABC transporter superfamily
IGS63_RS08370	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS63_RS08375	COG0649	NAD binding
IGS63_RS08380	COG0651	ATP synthesis coupled electron transport
IGS63_RS08390	COG0650	Formate hydrogenlyase subunit 4
IGS63_RS08395	COG0651	ATP synthesis coupled electron transport
IGS63_RS08405	COG1011	Hydrolase
IGS63_RS08410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IGS63_RS08415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGS63_RS08415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGS63_RS08420	COG0307	riboflavin synthase, alpha
IGS63_RS08425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IGS63_RS08425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IGS63_RS08430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IGS63_RS08435	COG1993	acr, cog1993
IGS63_RS08445	COG3708	Transcriptional regulator
IGS63_RS08445	COG2207	Transcriptional regulator
IGS63_RS08460	COG0312	modulator of DNA gyrase
IGS63_RS08470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGS63_RS08475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS63_RS08480	COG1028	Short-chain dehydrogenase reductase Sdr
IGS63_RS08485	COG0427	acetyl-CoA hydrolase
IGS63_RS08490	COG0183	Belongs to the thiolase family
IGS63_RS08515	COG2267	carboxylic ester hydrolase activity
IGS63_RS08520	COG1309	transcriptional regulator
IGS63_RS08540	COG0668	transmembrane transport
IGS63_RS08565	COG1132	(ABC) transporter
IGS63_RS08580	COG1846	Transcriptional regulator
IGS63_RS08585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IGS63_RS08620	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IGS63_RS08640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IGS63_RS08645	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IGS63_RS08650	COG0747	negative chemotaxis
IGS63_RS08660	COG2197	response regulator
IGS63_RS08665	COG4585	Histidine kinase
IGS63_RS08670	COG0326	Molecular chaperone. Has ATPase activity
IGS63_RS08680	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IGS63_RS08690	COG1408	metallophosphoesterase
IGS63_RS08715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGS63_RS08725	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IGS63_RS08725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IGS63_RS08730	COG0251	oxidation-reduction process
IGS63_RS08740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IGS63_RS08755	COG1254	Belongs to the acylphosphatase family
IGS63_RS08770	COG0581	inorganic phosphate transmembrane transporter activity
IGS63_RS08770	COG0573	inorganic phosphate transmembrane transporter activity
IGS63_RS08780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IGS63_RS08785	COG0704	Plays a role in the regulation of phosphate uptake
IGS63_RS08790	COG0745	RESPONSE REGULATOR receiver
IGS63_RS08795	COG5002	protein histidine kinase activity
IGS63_RS08810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS63_RS08815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IGS63_RS08820	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IGS63_RS08825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IGS63_RS08830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IGS63_RS08840	COG2203	Gaf domain
IGS63_RS08840	COG2199	diguanylate cyclase activity
IGS63_RS08845	COG0306	phosphate transporter
IGS63_RS08855	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IGS63_RS08865	COG0012	GTP binding
IGS63_RS08870	COG0802	atpase or kinase
IGS63_RS08890	COG1797	cobyrinic acid a,c-diamide synthase activity
IGS63_RS08900	COG1120	ATPase activity
IGS63_RS08905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS63_RS08980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IGS63_RS08985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IGS63_RS09005	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IGS63_RS09005	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IGS63_RS09025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IGS63_RS09030	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IGS63_RS09035	COG2081	HI0933 family
IGS63_RS09075	COG1136	(ABC) transporter
IGS63_RS09080	COG0105	UTP biosynthetic process
IGS63_RS09085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IGS63_RS09090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IGS63_RS09095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IGS63_RS09115	COG4656	Part of a membrane complex involved in electron transport
IGS63_RS09120	COG4658	electron transport chain
IGS63_RS09130	COG4660	Part of a membrane complex involved in electron transport
IGS63_RS09135	COG4657	Part of a membrane complex involved in electron transport
IGS63_RS09145	COG3706	GGDEF domain
IGS63_RS09150	COG1073	alpha beta
IGS63_RS09155	COG0747	negative chemotaxis
IGS63_RS09160	COG0601	transmembrane transport
IGS63_RS09170	COG0444	Belongs to the ABC transporter superfamily
IGS63_RS09175	COG4608	Belongs to the ABC transporter superfamily
IGS63_RS09180	COG2723	6-phospho-beta-galactosidase activity
IGS63_RS09210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IGS63_RS09220	COG2188	Transcriptional regulator
IGS63_RS09240	COG0395	ABC-type sugar transport system, permease component
IGS63_RS09245	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IGS63_RS09245	COG3291	Pkd domain containing protein
IGS63_RS09250	COG2235	arginine
IGS63_RS09255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IGS63_RS09260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS63_RS09265	COG1288	antiporter activity
IGS63_RS09280	COG2176	DNA-directed DNA polymerase activity
IGS63_RS09290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IGS63_RS09290	COG0617	tRNA 3'-terminal CCA addition
IGS63_RS09290	COG0517	IMP dehydrogenase activity
IGS63_RS09300	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IGS63_RS09320	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IGS63_RS09325	COG1596	polysaccharide export
IGS63_RS09325	COG1555	photosystem II stabilization
IGS63_RS09335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IGS63_RS09345	COG0698	ribose 5-phosphate isomerase
IGS63_RS09355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IGS63_RS09360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IGS63_RS09365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS63_RS09365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS63_RS09370	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IGS63_RS09390	COG0584	glycerophosphoryl diester phosphodiesterase
IGS63_RS09400	COG1979	alcohol dehydrogenase
IGS63_RS09410	COG0793	Belongs to the peptidase S41A family
IGS63_RS09435	COG0512	Glutamine amidotransferase of anthranilate synthase
IGS63_RS09445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IGS63_RS09450	COG0302	gtp cyclohydrolase
IGS63_RS09455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IGS63_RS09460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IGS63_RS09465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IGS63_RS09530	COG4245	von Willebrand factor, type A
IGS63_RS09555	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IGS63_RS09645	COG0085	RNA polymerase activity
IGS63_RS09720	COG1454	alcohol dehydrogenase
IGS63_RS09730	COG3234	Protein of unknown function (DUF1175)
IGS63_RS09735	COG0018	arginyl-trna synthetase
IGS63_RS09740	COG4214	carbohydrate transport
IGS63_RS09750	COG4213	ABC transporter substrate-binding protein
IGS63_RS09755	COG4191	Histidine kinase
IGS63_RS09760	COG2204	response regulator
IGS63_RS09785	COG1131	(ABC) transporter
IGS63_RS09810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IGS63_RS09815	COG3328	transposase activity
IGS63_RS09855	COG1131	(ABC) transporter
IGS63_RS09860	COG0535	radical SAM domain protein
IGS63_RS09865	COG0535	radical SAM domain protein
IGS63_RS09890	COG0823	Involved in the tonB-independent uptake of proteins
IGS63_RS09890	COG1506	peptidase
IGS63_RS09890	COG4946	Tricorn protease homolog
IGS63_RS09905	COG0745	RESPONSE REGULATOR receiver
IGS63_RS09910	COG5002	protein histidine kinase activity
IGS63_RS09935	COG0148	phosphopyruvate hydratase activity
IGS63_RS09940	COG0528	UMP kinase activity
IGS63_RS09945	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IGS63_RS09950	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IGS63_RS09955	COG0482	sulfurtransferase activity
IGS63_RS09960	COG1959	2 iron, 2 sulfur cluster binding
IGS63_RS09965	COG3584	3D domain protein
IGS63_RS09975	COG0552	protein localization to endoplasmic reticulum
IGS63_RS10005	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IGS63_RS10010	COG0544	peptidyl-prolyl cis-trans isomerase activity
IGS63_RS10035	COG0126	phosphoglycerate kinase activity
IGS63_RS10035	COG0149	triose-phosphate isomerase activity
IGS63_RS10045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IGS63_RS10065	COG0497	DNA recombination
IGS63_RS10080	COG3706	GGDEF domain
IGS63_RS10085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGS63_RS10105	COG1610	YqeY-like protein
IGS63_RS10110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IGS63_RS10115	COG0736	holo-[acyl-carrier-protein] synthase activity
IGS63_RS10125	COG1193	negative regulation of DNA recombination
IGS63_RS10135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IGS63_RS10140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IGS63_RS10150	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IGS63_RS10155	COG0740	serine-type endopeptidase activity
IGS63_RS10165	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IGS63_RS10170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IGS63_RS10175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IGS63_RS10185	COG1012	belongs to the aldehyde dehydrogenase family
IGS63_RS10200	COG0768	penicillin binding
IGS63_RS10215	COG1077	Cell shape determining protein MreB Mrl
IGS63_RS10220	COG1396	sequence-specific DNA binding
IGS63_RS10220	COG1917	Cupin 2, conserved barrel domain protein
IGS63_RS10225	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IGS63_RS10230	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IGS63_RS10245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IGS63_RS10245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGS63_RS10250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IGS63_RS10255	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IGS63_RS10265	COG0438	transferase activity, transferring glycosyl groups
IGS63_RS10285	COG1702	phosphate starvation-inducible protein PhoH
IGS63_RS10290	COG1480	7TM receptor with intracellular HD hydrolase
IGS63_RS10295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IGS63_RS10310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IGS63_RS10325	COG1045	serine acetyltransferase
IGS63_RS10350	COG2827	Endonuclease containing a URI domain
IGS63_RS10360	COG0784	Response regulator, receiver
IGS63_RS10360	COG2205	protein histidine kinase activity
IGS63_RS10365	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IGS63_RS10370	COG0275	rRNA processing
IGS63_RS10380	COG0768	penicillin binding
IGS63_RS10395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IGS63_RS10400	COG3586	endonuclease activity
IGS63_RS10420	COG5002	protein histidine kinase activity
IGS63_RS10425	COG1032	radical SAM domain protein
IGS63_RS10445	COG0442	prolyl-tRNA aminoacylation
IGS63_RS10450	COG1132	(ABC) transporter
IGS63_RS10455	COG1132	(ABC) transporter
IGS63_RS10465	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IGS63_RS10485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IGS63_RS10490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IGS63_RS10505	COG0187	DNA topoisomerase II activity
IGS63_RS10515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IGS63_RS10520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IGS63_RS10525	COG0517	IMP dehydrogenase activity
IGS63_RS10525	COG0516	GMP reductase activity
IGS63_RS10530	COG1105	Belongs to the carbohydrate kinase PfkB family
IGS63_RS10540	COG1309	transcriptional regulator
IGS63_RS10550	COG0301	tRNA thio-modification
IGS63_RS10570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IGS63_RS10605	COG1307	EDD domain protein, DegV family
IGS63_RS10610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IGS63_RS10615	COG0742	ribosomal rna small subunit methyltransferase
IGS63_RS10620	COG0640	Transcriptional regulator
IGS63_RS10625	COG2217	Heavy metal translocating P-type atpase
IGS63_RS10630	COG0860	N-Acetylmuramoyl-L-alanine amidase
IGS63_RS10635	COG0739	heme binding
IGS63_RS10640	COG2201	protein-glutamate methylesterase activity
IGS63_RS10645	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IGS63_RS10655	COG1013	pyruvate-flavodoxin oxidoreductase activity
IGS63_RS10660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IGS63_RS10675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGS63_RS10680	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IGS63_RS10715	COG2373	Large extracellular alpha-helical protein
IGS63_RS10720	COG0514	ATP-dependent DNA helicase (RecQ)
IGS63_RS10730	COG1051	belongs to the nudix hydrolase family
IGS63_RS10735	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IGS63_RS10760	COG2986	histidine ammonia-lyase
IGS63_RS10770	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IGS63_RS10810	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IGS63_RS10820	COG0835	chemotaxis
IGS63_RS10840	COG2199	diguanylate cyclase activity
IGS63_RS10840	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IGS63_RS10860	COG0330	HflC and HflK could
IGS63_RS10865	COG0330	HflC and HflK could
IGS63_RS10870	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IGS63_RS10870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IGS63_RS10875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IGS63_RS10880	COG0444	Belongs to the ABC transporter superfamily
IGS63_RS10885	COG4608	Belongs to the ABC transporter superfamily
IGS63_RS10895	COG0601	transmembrane transport
IGS63_RS10900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS63_RS10905	COG0840	transmembrane signaling receptor activity
IGS63_RS10910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGS63_RS10915	COG0543	2 iron, 2 sulfur cluster binding
IGS63_RS10920	COG0167	dihydroorotate dehydrogenase activity
IGS63_RS10925	COG0284	orotidine-5'-phosphate decarboxylase activity
IGS63_RS10930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IGS63_RS10935	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IGS63_RS10955	COG1362	aminopeptidase activity
IGS63_RS10975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IGS63_RS10980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IGS63_RS10985	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IGS63_RS10990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IGS63_RS11000	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IGS63_RS11005	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IGS63_RS11010	COG0356	it plays a direct role in the translocation of protons across the membrane
IGS63_RS11035	COG2078	PFAM AMMECR1 domain protein
IGS63_RS11045	COG1477	protein flavinylation
IGS63_RS11060	COG0424	maF-like protein
IGS63_RS11065	COG2003	Belongs to the UPF0758 family
IGS63_RS11075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IGS63_RS11080	COG4143	(ABC) transporter
IGS63_RS11085	COG1178	ABC-type Fe3 transport system permease component
IGS63_RS11120	COG1528	Iron-storage protein
IGS63_RS11125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IGS63_RS11130	COG0450	alkyl hydroperoxide reductase
IGS63_RS11165	COG1132	(ABC) transporter
IGS63_RS11175	COG1007	ATP synthesis coupled electron transport
IGS63_RS11215	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IGS63_RS11225	COG2199	diguanylate cyclase activity
IGS63_RS11225	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IGS63_RS11230	COG3437	response regulator, receiver
IGS63_RS11235	COG0612	Peptidase, M16
IGS63_RS11240	COG1185	polyribonucleotide nucleotidyltransferase activity
IGS63_RS11245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IGS63_RS11270	COG3706	GGDEF domain
IGS63_RS11285	COG1307	EDD domain protein, DegV family
IGS63_RS11290	COG1924	4 iron, 4 sulfur cluster binding
IGS63_RS11295	COG2226	methyltransferase
IGS63_RS11300	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IGS63_RS11310	COG0436	Aminotransferase
IGS63_RS11320	COG2723	6-phospho-beta-galactosidase activity
IGS63_RS11330	COG0737	Belongs to the 5'-nucleotidase family
IGS63_RS11330	COG1525	nuclease
IGS63_RS11330	COG4085	toxin activity
IGS63_RS11340	COG1760	l-serine dehydratase
IGS63_RS11345	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IGS63_RS11345	COG1215	transferase activity, transferring glycosyl groups
IGS63_RS11350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IGS63_RS11360	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IGS63_RS11365	COG0562	UDP-galactopyranose mutase
IGS63_RS11370	COG1215	transferase activity, transferring glycosyl groups
IGS63_RS11380	COG0438	transferase activity, transferring glycosyl groups
IGS63_RS11385	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IGS63_RS11405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IGS63_RS11420	COG1523	belongs to the glycosyl hydrolase 13 family
IGS63_RS11425	COG0481	GTPase activity
IGS63_RS11435	COG0556	nucleotide-excision repair
IGS63_RS11440	COG1011	Hydrolase
IGS63_RS11445	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IGS63_RS11450	COG0085	RNA polymerase activity
IGS63_RS11455	COG0222	ribosome binding
IGS63_RS11460	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IGS63_RS11465	COG0081	regulation of translation
IGS63_RS11470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IGS63_RS11475	COG0250	Participates in transcription elongation, termination and antitermination
IGS63_RS11480	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IGS63_RS11485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IGS63_RS11505	COG0542	response to heat
IGS63_RS11510	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IGS63_RS11515	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IGS63_RS11520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IGS63_RS11530	COG1187	pseudouridine synthase activity
IGS63_RS11535	COG1846	Transcriptional regulator
IGS63_RS11550	COG1752	Esterase of the alpha-beta hydrolase superfamily
IGS63_RS11565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IGS63_RS11570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IGS63_RS11590	COG1749	Flagellar hook protein flgE
IGS63_RS11615	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IGS63_RS11620	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IGS63_RS11620	COG1776	CheC inhibitor of MCP methylation
IGS63_RS11635	COG1132	(ABC) transporter
IGS63_RS11640	COG1132	(ABC) transporter