locus-tag	class	description
E4K71_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4K71_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4K71_RS00025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4K71_RS00045	COG1121	(ABC) transporter
E4K71_RS00050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4K71_RS00060	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4K71_RS00065	COG0124	histidyl-tRNA synthetase
E4K71_RS00070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4K71_RS00080	COG2890	protein-(glutamine-N5) methyltransferase activity
E4K71_RS00095	COG0542	response to heat
E4K71_RS00110	COG0739	heme binding
E4K71_RS00155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4K71_RS00165	COG3852	Histidine kinase
E4K71_RS00195	COG2801	Transposase and inactivated derivatives
E4K71_RS00225	COG0583	DNA-binding transcription factor activity
E4K71_RS00230	COG2801	Transposase and inactivated derivatives
E4K71_RS00345	COG1396	sequence-specific DNA binding
E4K71_RS00435	COG3051	citrate lyase alpha subunit
E4K71_RS00440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4K71_RS00445	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4K71_RS00450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4K71_RS00455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4K71_RS00460	COG0583	DNA-binding transcription factor activity
E4K71_RS00465	COG1960	acyl-CoA dehydrogenase activity
E4K71_RS00470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4K71_RS00475	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
E4K71_RS00480	COG2301	Belongs to the HpcH HpaI aldolase family
E4K71_RS00535	COG0539	negative regulation of cytoplasmic translation
E4K71_RS00540	COG0616	signal peptide processing
E4K71_RS00545	COG0776	regulation of translation
E4K71_RS00590	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4K71_RS00590	COG1918	ferrous iron import across plasma membrane
E4K71_RS00640	COG4818	TM2 domain
E4K71_RS00680	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4K71_RS00685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4K71_RS00685	COG0730	response to heat
E4K71_RS00700	COG1704	LemA family
E4K71_RS00760	COG0668	transmembrane transport
E4K71_RS00770	COG3437	response regulator, receiver
E4K71_RS00775	COG3279	Response regulator of the LytR AlgR family
E4K71_RS00815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4K71_RS00820	COG0642	Histidine kinase
E4K71_RS00825	COG0745	RESPONSE REGULATOR receiver
E4K71_RS00830	COG0840	transmembrane signaling receptor activity
E4K71_RS00865	COG2204	response regulator
E4K71_RS00870	COG0309	Hydrogenase expression formation protein (HypE)
E4K71_RS00875	COG0409	Hydrogenase expression formation protein
E4K71_RS00890	COG0375	protein maturation
E4K71_RS00910	COG1773	rubredoxin
E4K71_RS00940	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4K71_RS00945	COG1879	ABC-type sugar transport system periplasmic component
E4K71_RS00955	COG0745	RESPONSE REGULATOR receiver
E4K71_RS00970	COG2207	Transcriptional regulator
E4K71_RS00970	COG4753	response regulator
E4K71_RS00975	COG0683	leucine binding
E4K71_RS00980	COG4191	Histidine kinase
E4K71_RS00980	COG0784	Response regulator, receiver
E4K71_RS00995	COG1639	'signal transduction protein
E4K71_RS01000	COG2204	response regulator
E4K71_RS01010	COG2205	protein histidine kinase activity
E4K71_RS01010	COG4999	Histidine kinase
E4K71_RS01010	COG3850	Histidine kinase
E4K71_RS01010	COG3437	response regulator, receiver
E4K71_RS01020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4K71_RS01025	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4K71_RS01030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4K71_RS01035	COG2967	ApaG domain
E4K71_RS01055	COG0235	Class ii aldolase
E4K71_RS01065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E4K71_RS01070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4K71_RS01075	COG4597	amino acid ABC transporter
E4K71_RS01080	COG0765	amino acid transport
E4K71_RS01085	COG1126	abc transporter atp-binding protein
E4K71_RS01090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4K71_RS01110	COG2205	protein histidine kinase activity
E4K71_RS01110	COG0784	Response regulator, receiver
E4K71_RS01115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4K71_RS01115	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4K71_RS01125	COG0243	molybdopterin cofactor binding
E4K71_RS01130	COG0437	4 iron, 4 sulfur cluster binding
E4K71_RS01135	COG0348	domain, Protein
E4K71_RS01150	COG0277	FAD linked oxidase domain protein
E4K71_RS01150	COG0247	lactate metabolic process
E4K71_RS01185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4K71_RS01205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4K71_RS01230	COG0697	spore germination
E4K71_RS01250	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E4K71_RS01265	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4K71_RS01270	COG0678	peroxiredoxin activity
E4K71_RS01275	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4K71_RS01285	COG0602	queuosine metabolic process
E4K71_RS01295	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4K71_RS01300	COG0318	PFAM AMP-dependent synthetase and ligase
E4K71_RS01310	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4K71_RS01340	COG0741	lytic transglycosylase activity
E4K71_RS01395	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4K71_RS01410	COG2205	protein histidine kinase activity
E4K71_RS01410	COG0784	Response regulator, receiver
E4K71_RS01410	COG5002	protein histidine kinase activity
E4K71_RS01420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4K71_RS01460	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4K71_RS01490	COG1704	LemA family
E4K71_RS01510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4K71_RS01535	COG1115	amino acid carrier protein
E4K71_RS01540	COG1840	ABC-type Fe3 transport system, periplasmic component
E4K71_RS01545	COG1178	ABC-type Fe3 transport system permease component
E4K71_RS01550	COG3842	ATPase activity
E4K71_RS01570	COG0633	Ferredoxin
E4K71_RS01570	COG0543	2 iron, 2 sulfur cluster binding
E4K71_RS01575	COG1151	hydroxylamine reductase activity
E4K71_RS01630	COG1028	Short-chain dehydrogenase reductase Sdr
E4K71_RS01645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4K71_RS01650	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4K71_RS01665	COG0784	Response regulator, receiver
E4K71_RS01665	COG5002	protein histidine kinase activity
E4K71_RS01670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4K71_RS01680	COG2855	membrane
E4K71_RS01705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4K71_RS01715	COG3128	pkhd-type hydroxylase
E4K71_RS01740	COG5002	protein histidine kinase activity
E4K71_RS01740	COG2198	Histidine kinase
E4K71_RS01740	COG0784	Response regulator, receiver
E4K71_RS01755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4K71_RS01770	COG1127	ABC transporter
E4K71_RS01775	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4K71_RS01785	COG2172	sigma factor antagonist activity
E4K71_RS01805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4K71_RS01830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4K71_RS01835	COG0343	queuine tRNA-ribosyltransferase activity
E4K71_RS01840	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4K71_RS01845	COG0625	glutathione transferase activity
E4K71_RS01855	COG1393	Belongs to the ArsC family
E4K71_RS01860	COG0028	Belongs to the TPP enzyme family
E4K71_RS01895	COG0436	Aminotransferase
E4K71_RS01910	COG0556	nucleotide-excision repair
E4K71_RS01915	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4K71_RS01920	COG1280	lysine exporter protein (LysE YggA)
E4K71_RS01925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4K71_RS01935	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4K71_RS01960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4K71_RS01965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4K71_RS01975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4K71_RS01985	COG4974	Belongs to the 'phage' integrase family
E4K71_RS02000	COG5002	protein histidine kinase activity
E4K71_RS02000	COG2176	DNA-directed DNA polymerase activity
E4K71_RS02010	COG0488	(ABC) transporter
E4K71_RS02015	COG2205	protein histidine kinase activity
E4K71_RS02015	COG2198	Histidine kinase
E4K71_RS02015	COG0784	Response regulator, receiver
E4K71_RS02030	COG0564	pseudouridine synthase activity
E4K71_RS02040	COG2853	Lipoprotein
E4K71_RS02045	COG2226	methyltransferase
E4K71_RS02075	COG3706	GGDEF domain
E4K71_RS02080	COG0038	chloride channel
E4K71_RS02085	COG0210	DNA helicase
E4K71_RS02090	COG2264	protein methyltransferase activity
E4K71_RS02100	COG0840	transmembrane signaling receptor activity
E4K71_RS02130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4K71_RS02135	COG2358	TRAP transporter, solute receptor (TAXI family
E4K71_RS02155	COG5265	(ABC) transporter
E4K71_RS02160	COG0604	alcohol dehydrogenase
E4K71_RS02170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4K71_RS02195	COG0471	metal ion transport
E4K71_RS02195	COG3273	potassium ion transport
E4K71_RS02210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4K71_RS02225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4K71_RS02230	COG1346	cytolysis
E4K71_RS02235	COG1380	Effector of murein hydrolase LrgA
E4K71_RS02260	COG0643	Histidine kinase
E4K71_RS02260	COG0784	Response regulator, receiver
E4K71_RS02260	COG2198	Histidine kinase
E4K71_RS02265	COG0745	RESPONSE REGULATOR receiver
E4K71_RS02275	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4K71_RS02285	COG0745	RESPONSE REGULATOR receiver
E4K71_RS02310	COG0489	protein tyrosine kinase activity
E4K71_RS02320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4K71_RS02325	COG2204	response regulator
E4K71_RS02330	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4K71_RS02335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4K71_RS02345	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4K71_RS02350	COG1766	The M ring may be actively involved in energy transduction
E4K71_RS02355	COG1749	Flagellar hook protein flgE
E4K71_RS02385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4K71_RS02410	COG1086	Polysaccharide biosynthesis protein
E4K71_RS02430	COG2089	acid synthase
E4K71_RS02435	COG0028	Belongs to the TPP enzyme family
E4K71_RS02445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4K71_RS02465	COG1979	alcohol dehydrogenase
E4K71_RS02470	COG1216	Glycosyl transferase, family 2
E4K71_RS02475	COG0300	oxidoreductase activity
E4K71_RS02500	COG0463	Glycosyl transferase, family 2
E4K71_RS02515	COG3547	Transposase (IS116 IS110 IS902 family)
E4K71_RS02545	COG3415	Transposase
E4K71_RS02555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4K71_RS02590	COG2089	acid synthase
E4K71_RS02595	COG0673	inositol 2-dehydrogenase activity
E4K71_RS02605	COG1083	cytidylyl-transferase
E4K71_RS02615	COG1256	bacterial-type flagellum assembly
E4K71_RS02615	COG4786	Flagellar basal body rod
E4K71_RS02635	COG3676	manually curated
E4K71_RS02665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4K71_RS02690	COG2313	pseudouridylate synthase activity
E4K71_RS02695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4K71_RS02705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4K71_RS02710	COG0352	thiamine-phosphate diphosphorylase activity
E4K71_RS02735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4K71_RS02740	COG1692	metallophosphoesterase
E4K71_RS02745	COG0840	transmembrane signaling receptor activity
E4K71_RS02745	COG2972	Histidine kinase
E4K71_RS02750	COG0217	transcriptional regulatory protein
E4K71_RS02755	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4K71_RS02770	COG0824	Thioesterase
E4K71_RS02790	COG0823	Involved in the tonB-independent uptake of proteins
E4K71_RS02795	COG2885	chlorophyll binding
E4K71_RS02805	COG0037	tRNA processing
E4K71_RS02810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4K71_RS02815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4K71_RS02820	COG1739	Uncharacterized protein family UPF0029
E4K71_RS02830	COG0352	thiamine-phosphate diphosphorylase activity
E4K71_RS02830	COG0351	phosphomethylpyrimidine kinase
E4K71_RS02835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4K71_RS02900	COG3474	cytochrome
E4K71_RS02920	COG1132	(ABC) transporter
E4K71_RS02930	COG3005	denitrification pathway
E4K71_RS02945	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E4K71_RS02950	COG0746	molybdenum cofactor guanylyltransferase activity
E4K71_RS02955	COG2186	Transcriptional regulator
E4K71_RS02960	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E4K71_RS02970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4K71_RS02975	COG0247	lactate metabolic process
E4K71_RS02990	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E4K71_RS02995	COG0840	transmembrane signaling receptor activity
E4K71_RS03005	COG1858	cytochrome C peroxidase
E4K71_RS03010	COG2205	protein histidine kinase activity
E4K71_RS03010	COG0784	Response regulator, receiver
E4K71_RS03010	COG5002	protein histidine kinase activity
E4K71_RS03015	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4K71_RS03020	COG1984	allophanate hydrolase subunit 2
E4K71_RS03025	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E4K71_RS03030	COG0840	transmembrane signaling receptor activity
E4K71_RS03035	COG3707	response regulator
E4K71_RS03040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4K71_RS03040	COG1116	anion transmembrane transporter activity
E4K71_RS03045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4K71_RS03050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4K71_RS03055	COG1116	anion transmembrane transporter activity
E4K71_RS03060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4K71_RS03070	COG0243	molybdopterin cofactor binding
E4K71_RS03080	COG5002	protein histidine kinase activity
E4K71_RS03105	COG0347	Belongs to the P(II) protein family
E4K71_RS03155	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4K71_RS03160	COG0473	3-isopropylmalate dehydrogenase activity
E4K71_RS03165	COG3395	kinase activity
E4K71_RS03170	COG0235	Class ii aldolase
E4K71_RS03180	COG0840	transmembrane signaling receptor activity
E4K71_RS03185	COG2202	Pas domain
E4K71_RS03185	COG2205	protein histidine kinase activity
E4K71_RS03190	COG2186	Transcriptional regulator
E4K71_RS03195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4K71_RS03200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4K71_RS03205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4K71_RS03210	COG4948	Mandelate Racemase Muconate Lactonizing
E4K71_RS03215	COG1063	alcohol dehydrogenase
E4K71_RS03220	COG1028	Short-chain dehydrogenase reductase Sdr
E4K71_RS03225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4K71_RS03230	COG0800	Aldolase
E4K71_RS03235	COG0469	pyruvate kinase activity
E4K71_RS03240	COG1803	Methylglyoxal synthase
E4K71_RS03245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4K71_RS03245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4K71_RS03250	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E4K71_RS03255	COG0148	phosphopyruvate hydratase activity
E4K71_RS03270	COG3547	Transposase (IS116 IS110 IS902 family)
E4K71_RS03290	COG0519	Catalyzes the synthesis of GMP from XMP
E4K71_RS03300	COG0730	response to heat
E4K71_RS03305	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4K71_RS03305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4K71_RS03310	COG0517	IMP dehydrogenase activity
E4K71_RS03310	COG0516	GMP reductase activity
E4K71_RS03330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4K71_RS03335	COG0517	IMP dehydrogenase activity
E4K71_RS03335	COG0617	tRNA 3'-terminal CCA addition
E4K71_RS03335	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4K71_RS03360	COG3360	Dodecin
E4K71_RS03365	COG2205	protein histidine kinase activity
E4K71_RS03385	COG0745	RESPONSE REGULATOR receiver
E4K71_RS03390	COG0156	8-amino-7-oxononanoate synthase activity
E4K71_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
E4K71_RS03420	COG2135	peptidase activity
E4K71_RS03430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4K71_RS03435	COG1846	Transcriptional regulator
E4K71_RS03450	COG1652	LysM domain
E4K71_RS03450	COG2823	Periplasmic or secreted lipoprotein
E4K71_RS03460	COG1183	phosphatidylcholine synthase activity
E4K71_RS03480	COG0418	dihydroorotase activity
E4K71_RS03485	COG0730	response to heat
E4K71_RS03490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4K71_RS03495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4K71_RS03500	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4K71_RS03505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4K71_RS03510	COG1230	cation diffusion facilitator family transporter
E4K71_RS03535	COG3660	Nucleoside-diphosphate-sugar epimerase
E4K71_RS03565	COG0277	FAD linked oxidase domain protein
E4K71_RS03575	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4K71_RS03580	COG0154	amidase activity
E4K71_RS03585	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4K71_RS03600	COG0625	glutathione transferase activity
E4K71_RS03655	COG0105	UTP biosynthetic process
E4K71_RS03660	COG0488	(ABC) transporter
E4K71_RS03675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4K71_RS03725	COG0840	transmembrane signaling receptor activity
E4K71_RS03735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4K71_RS03740	COG0306	phosphate transporter
E4K71_RS03745	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4K71_RS03750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4K71_RS03765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4K71_RS03770	COG0628	permease
E4K71_RS03790	COG4566	intracellular signal transduction
E4K71_RS03800	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4K71_RS03830	COG1648	precorrin-2 dehydrogenase activity
E4K71_RS03830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4K71_RS03850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4K71_RS03860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4K71_RS03890	COG1960	acyl-CoA dehydrogenase activity
E4K71_RS03905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4K71_RS03955	COG1940	carbohydrate kinase activity
E4K71_RS03975	COG0640	Transcriptional regulator
E4K71_RS03995	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4K71_RS04005	COG0142	geranyltranstransferase activity
E4K71_RS04010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4K71_RS04015	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E4K71_RS04035	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4K71_RS04055	COG1671	Belongs to the UPF0178 family
E4K71_RS04065	COG0484	heat shock protein binding
E4K71_RS04080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4K71_RS04090	COG0640	Transcriptional regulator
E4K71_RS04110	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4K71_RS04115	COG1473	amidohydrolase
E4K71_RS04130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4K71_RS04135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4K71_RS04145	COG1959	2 iron, 2 sulfur cluster binding
E4K71_RS04155	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4K71_RS04170	COG0348	domain, Protein
E4K71_RS04175	COG1725	Transcriptional regulator
E4K71_RS04195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4K71_RS04200	COG0679	Auxin Efflux Carrier
E4K71_RS04225	COG1024	Enoyl-CoA hydratase
E4K71_RS04230	COG1832	CoA-binding protein
E4K71_RS04235	COG2827	Endonuclease containing a URI domain
E4K71_RS04240	COG2267	carboxylic ester hydrolase activity
E4K71_RS04270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4K71_RS04275	COG3123	guanosine phosphorylase activity
E4K71_RS04280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4K71_RS04290	COG3676	manually curated
E4K71_RS04300	COG0730	response to heat
E4K71_RS04315	COG3328	transposase activity
E4K71_RS04325	COG0469	pyruvate kinase activity
E4K71_RS04330	COG0148	phosphopyruvate hydratase activity
E4K71_RS04350	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E4K71_RS04365	COG4948	Mandelate Racemase Muconate Lactonizing
E4K71_RS04375	COG0436	Aminotransferase
E4K71_RS04430	COG0187	DNA topoisomerase II activity
E4K71_RS04440	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4K71_RS04465	COG3547	Transposase (IS116 IS110 IS902 family)
E4K71_RS04470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4K71_RS04480	COG0629	single-stranded DNA binding
E4K71_RS04490	COG2832	Protein of unknown function (DUF454)
E4K71_RS04500	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4K71_RS04515	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4K71_RS04520	COG2205	protein histidine kinase activity
E4K71_RS04520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4K71_RS04525	COG0242	peptide deformylase activity
E4K71_RS04540	COG2814	Major facilitator Superfamily
E4K71_RS04545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4K71_RS04550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4K71_RS04565	COG0205	6-phosphofructokinase activity
E4K71_RS04575	COG0840	transmembrane signaling receptor activity
E4K71_RS04580	COG0318	PFAM AMP-dependent synthetase and ligase
E4K71_RS04595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4K71_RS04630	COG4964	Belongs to the GSP D family
E4K71_RS04700	COG2414	aldehyde ferredoxin oxidoreductase
E4K71_RS04715	COG3012	SEC-C Motif Domain Protein
E4K71_RS04735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4K71_RS04740	COG0745	RESPONSE REGULATOR receiver
E4K71_RS04750	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4K71_RS04755	COG0248	Ppx GppA phosphatase
E4K71_RS04775	COG0469	pyruvate kinase activity
E4K71_RS04795	COG1022	Amp-dependent synthetase and ligase
E4K71_RS04815	COG5001	Diguanylate cyclase
E4K71_RS04815	COG3300	MHYT domain
E4K71_RS04825	COG3437	response regulator, receiver
E4K71_RS04830	COG2205	protein histidine kinase activity
E4K71_RS04830	COG0784	Response regulator, receiver
E4K71_RS04870	COG3850	Histidine kinase
E4K71_RS04870	COG2205	protein histidine kinase activity
E4K71_RS04870	COG3437	response regulator, receiver
E4K71_RS04870	COG4999	Histidine kinase
E4K71_RS04930	COG3668	Plasmid stabilization system
E4K71_RS04970	COG3676	manually curated
E4K71_RS05000	COG0443	Heat shock 70 kDa protein
E4K71_RS05040	COG2801	Transposase and inactivated derivatives
E4K71_RS05045	COG2801	Transposase and inactivated derivatives
E4K71_RS05105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4K71_RS05120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4K71_RS05135	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4K71_RS05140	COG0250	Participates in transcription elongation, termination and antitermination
E4K71_RS05145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4K71_RS05155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4K71_RS05160	COG0222	ribosome binding
E4K71_RS05170	COG0085	RNA polymerase activity
E4K71_RS05175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4K71_RS05225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4K71_RS05240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4K71_RS05245	COG0088	Forms part of the polypeptide exit tunnel
E4K71_RS05260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4K71_RS05265	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4K71_RS05270	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4K71_RS05275	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4K71_RS05280	COG0255	Belongs to the universal ribosomal protein uL29 family
E4K71_RS05285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4K71_RS05290	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4K71_RS05295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4K71_RS05300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4K71_RS05305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4K71_RS05310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4K71_RS05315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4K71_RS05320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4K71_RS05325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4K71_RS05330	COG1841	ribosomal large subunit assembly
E4K71_RS05335	COG0200	Binds to the 23S rRNA
E4K71_RS05340	COG0201	protein transport
E4K71_RS05345	COG0563	adenylate kinase activity
E4K71_RS05350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4K71_RS05365	COG0203	ribosomal protein L17
E4K71_RS05370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4K71_RS05375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4K71_RS05385	COG0745	RESPONSE REGULATOR receiver
E4K71_RS05390	COG2202	Pas domain
E4K71_RS05390	COG2205	protein histidine kinase activity
E4K71_RS05405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4K71_RS05415	COG1254	Belongs to the acylphosphatase family
E4K71_RS05425	COG4770	biotin carboxylase activity
E4K71_RS05430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4K71_RS05450	COG0546	phosphoglycolate phosphatase activity
E4K71_RS05460	COG0321	lipoyl(octanoyl) transferase activity
E4K71_RS05470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4K71_RS05475	COG2274	protein secretion by the type I secretion system
E4K71_RS05495	COG0280	phosphate acetyltransferase
E4K71_RS05495	COG0281	malic enzyme
E4K71_RS05500	COG2239	Acts as a magnesium transporter
E4K71_RS05505	COG0789	Transcriptional regulator
E4K71_RS05530	COG1960	acyl-CoA dehydrogenase activity
E4K71_RS05535	COG0183	Belongs to the thiolase family
E4K71_RS05540	COG1960	acyl-CoA dehydrogenase activity
E4K71_RS05550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4K71_RS05555	COG1024	Enoyl-CoA hydratase
E4K71_RS05560	COG4770	biotin carboxylase activity
E4K71_RS05590	COG1522	sequence-specific DNA binding
E4K71_RS05600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4K71_RS05645	COG0243	molybdopterin cofactor binding
E4K71_RS05670	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E4K71_RS05680	COG2197	response regulator
E4K71_RS05685	COG1686	Belongs to the peptidase S11 family
E4K71_RS05710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4K71_RS05730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4K71_RS05735	COG5001	Diguanylate cyclase
E4K71_RS05735	COG4251	negative regulation of phosphorylation
E4K71_RS05735	COG3706	GGDEF domain
E4K71_RS05735	COG2203	Gaf domain
E4K71_RS05760	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4K71_RS05765	COG0439	Biotin carboxylase
E4K71_RS05770	COG0511	ligase activity, forming carbon-carbon bonds
E4K71_RS05775	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4K71_RS05790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4K71_RS05790	COG0519	Catalyzes the synthesis of GMP from XMP
E4K71_RS05795	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4K71_RS05800	COG2951	lytic endotransglycosylase activity
E4K71_RS05810	COG1686	Belongs to the peptidase S11 family
E4K71_RS05815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4K71_RS05825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4K71_RS05830	COG0084	hydrolase, TatD family'
E4K71_RS05835	COG0321	lipoyl(octanoyl) transferase activity
E4K71_RS05835	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4K71_RS05935	COG3956	TIGRFAM MazG family protein
E4K71_RS05940	COG2084	Dehydrogenase
E4K71_RS05945	COG0514	ATP-dependent DNA helicase (RecQ)
E4K71_RS05950	COG0483	inositol monophosphate 1-phosphatase activity
E4K71_RS05970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4K71_RS05975	COG1923	regulation of RNA biosynthetic process
E4K71_RS05980	COG0546	phosphoglycolate phosphatase activity
E4K71_RS05990	COG0569	domain protein
E4K71_RS05995	COG2204	response regulator
E4K71_RS06050	COG0778	Nitroreductase
E4K71_RS06055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4K71_RS06060	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4K71_RS06065	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4K71_RS06065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4K71_RS06080	COG3676	manually curated
E4K71_RS06090	COG3909	cytochrome
E4K71_RS06100	COG4191	Histidine kinase
E4K71_RS06100	COG0784	Response regulator, receiver
E4K71_RS06140	COG3609	addiction module antidote protein, CC2985 family
E4K71_RS06200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4K71_RS06205	COG0416	fatty acid biosynthetic process
E4K71_RS06210	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4K71_RS06235	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4K71_RS06240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4K71_RS06250	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4K71_RS06250	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4K71_RS06260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4K71_RS06260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4K71_RS06265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4K71_RS06270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4K71_RS06275	COG0698	ribose 5-phosphate isomerase
E4K71_RS06285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4K71_RS06285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4K71_RS06290	COG1703	isobutyryl-CoA mutase activity
E4K71_RS06290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4K71_RS06290	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4K71_RS06300	COG0113	porphobilinogen synthase activity
E4K71_RS06305	COG0835	chemotaxis
E4K71_RS06315	COG1024	Enoyl-CoA hydratase
E4K71_RS06330	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E4K71_RS06335	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E4K71_RS06345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4K71_RS06355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4K71_RS06360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4K71_RS06365	COG1381	Involved in DNA repair and RecF pathway recombination
E4K71_RS06385	COG0571	ribonuclease III activity
E4K71_RS06390	COG0681	Belongs to the peptidase S26 family
E4K71_RS06395	COG0736	holo-[acyl-carrier-protein] synthase activity
E4K71_RS06400	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4K71_RS06415	COG1758	RNA polymerase activity
E4K71_RS06420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4K71_RS06430	COG1573	uracil-dna glycosylase
E4K71_RS06435	COG0560	Phosphoserine phosphatase
E4K71_RS06460	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4K71_RS06465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4K71_RS06495	COG0739	heme binding
E4K71_RS06500	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4K71_RS06505	COG1058	Belongs to the CinA family
E4K71_RS06505	COG1546	Belongs to the CinA family
E4K71_RS06510	COG2867	negative regulation of translational initiation
E4K71_RS06515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4K71_RS06520	COG2226	methyltransferase
E4K71_RS06525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4K71_RS06530	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4K71_RS06535	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4K71_RS06535	COG0022	dehydrogenase e1 component
E4K71_RS06540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4K71_RS06545	COG2329	Antibiotic biosynthesis monooxygenase
E4K71_RS06550	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4K71_RS06555	COG0148	phosphopyruvate hydratase activity
E4K71_RS06580	COG0149	triose-phosphate isomerase activity
E4K71_RS06590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4K71_RS06600	COG2861	carbohydrate metabolic process
E4K71_RS06610	COG2217	Heavy metal translocating P-type atpase
E4K71_RS06620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4K71_RS06630	COG0315	cyclic pyranopterin monophosphate synthase activity
E4K71_RS06645	COG2333	competence protein COMEC
E4K71_RS06645	COG0658	competence protein
E4K71_RS06655	COG0372	Belongs to the citrate synthase family
E4K71_RS06675	COG0346	lactoylglutathione lyase activity
E4K71_RS06680	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4K71_RS06685	COG3494	Protein of unknown function (DUF1009)
E4K71_RS06710	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4K71_RS06715	COG0750	zinc metalloprotease
E4K71_RS06720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4K71_RS06730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4K71_RS06740	COG0528	UMP kinase activity
E4K71_RS06765	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4K71_RS06785	COG0517	IMP dehydrogenase activity
E4K71_RS06785	COG1125	glycine betaine transport
E4K71_RS06790	COG1136	(ABC) transporter
E4K71_RS06800	COG0442	prolyl-tRNA aminoacylation
E4K71_RS06810	COG0519	Catalyzes the synthesis of GMP from XMP
E4K71_RS06820	COG0346	lactoylglutathione lyase activity
E4K71_RS06840	COG1007	ATP synthesis coupled electron transport
E4K71_RS06855	COG0713	ATP synthesis coupled electron transport
E4K71_RS06870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E4K71_RS06875	COG1034	ATP synthesis coupled electron transport
E4K71_RS06880	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E4K71_RS06885	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E4K71_RS06905	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4K71_RS06925	COG0776	regulation of translation
E4K71_RS06955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4K71_RS06955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4K71_RS06970	COG0494	nUDIX hydrolase
E4K71_RS06975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4K71_RS06980	COG2897	thiosulfate sulfurtransferase activity
E4K71_RS06985	COG0626	cystathionine gamma-synthase activity
E4K71_RS06995	COG0745	RESPONSE REGULATOR receiver
E4K71_RS07030	COG1863	multisubunit Na H antiporter MnhE subunit
E4K71_RS07040	COG1320	monovalent cation:proton antiporter activity
E4K71_RS07055	COG1006	Multisubunit Na H antiporter MnhC subunit
E4K71_RS07060	COG0651	ATP synthesis coupled electron transport
E4K71_RS07065	COG0651	ATP synthesis coupled electron transport
E4K71_RS07075	COG2111	Na H antiporter
E4K71_RS07075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4K71_RS07100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4K71_RS07110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4K71_RS07120	COG1562	ergosterol biosynthetic process
E4K71_RS07125	COG1562	ergosterol biosynthetic process
E4K71_RS07130	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E4K71_RS07135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4K71_RS07140	COG3737	Protein of unknown function (DUF498/DUF598)
E4K71_RS07155	COG1862	Preprotein translocase
E4K71_RS07180	COG0316	Belongs to the HesB IscA family
E4K71_RS07185	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4K71_RS07200	COG1472	Belongs to the glycosyl hydrolase 3 family
E4K71_RS07205	COG1994	Peptidase M50
E4K71_RS07210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4K71_RS07215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4K71_RS07220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4K71_RS07225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4K71_RS07230	COG0805	protein transport
E4K71_RS07260	COG0129	dihydroxy-acid dehydratase activity
E4K71_RS07275	COG0525	valine-tRNA ligase activity
E4K71_RS07285	COG1538	Outer membrane efflux protein
E4K71_RS07290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4K71_RS07310	COG1396	sequence-specific DNA binding
E4K71_RS07315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4K71_RS07320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4K71_RS07320	COG1042	CoA-binding domain protein
E4K71_RS07320	COG0045	succinate-CoA ligase (ADP-forming) activity
E4K71_RS07345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4K71_RS07350	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4K71_RS07370	COG1234	tRNA 3'-trailer cleavage
E4K71_RS07390	COG0745	RESPONSE REGULATOR receiver
E4K71_RS07405	COG0581	inorganic phosphate transmembrane transporter activity
E4K71_RS07410	COG0573	inorganic phosphate transmembrane transporter activity
E4K71_RS07420	COG5002	protein histidine kinase activity
E4K71_RS07430	COG0745	RESPONSE REGULATOR receiver
E4K71_RS07435	COG2197	response regulator
E4K71_RS07445	COG4106	trans-aconitate 2-methyltransferase activity
E4K71_RS07445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4K71_RS07455	COG0156	8-amino-7-oxononanoate synthase activity
E4K71_RS07460	COG0596	Alpha beta hydrolase
E4K71_RS07480	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4K71_RS07480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4K71_RS07520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4K71_RS07525	COG2322	membrane
E4K71_RS07530	COG1612	heme a metabolic process
E4K71_RS07545	COG0745	RESPONSE REGULATOR receiver
E4K71_RS07565	COG0745	RESPONSE REGULATOR receiver
E4K71_RS07575	COG2201	protein-glutamate methylesterase activity
E4K71_RS07580	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E4K71_RS07590	COG0840	transmembrane signaling receptor activity
E4K71_RS07600	COG2198	Histidine kinase
E4K71_RS07600	COG0643	Histidine kinase
E4K71_RS07640	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4K71_RS07645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4K71_RS07650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4K71_RS07650	COG0301	tRNA thio-modification
E4K71_RS07660	COG1760	l-serine dehydratase
E4K71_RS07710	COG4974	Belongs to the 'phage' integrase family
E4K71_RS07765	COG0840	transmembrane signaling receptor activity
E4K71_RS07790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4K71_RS07825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4K71_RS07830	COG2274	protein secretion by the type I secretion system
E4K71_RS07835	COG2274	protein secretion by the type I secretion system
E4K71_RS07845	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4K71_RS07850	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4K71_RS07880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4K71_RS07920	COG0436	Aminotransferase
E4K71_RS07930	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4K71_RS07935	COG2267	carboxylic ester hydrolase activity
E4K71_RS07945	COG0513	Belongs to the DEAD box helicase family
E4K71_RS07950	COG0019	diaminopimelate decarboxylase activity
E4K71_RS07990	COG1278	Cold shock
E4K71_RS08040	COG2719	SpoVR family
E4K71_RS08045	COG2718	Belongs to the UPF0229 family
E4K71_RS08050	COG2766	serine protein kinase
E4K71_RS08060	COG1960	acyl-CoA dehydrogenase activity
E4K71_RS08065	COG1024	Enoyl-CoA hydratase
E4K71_RS08065	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4K71_RS08070	COG0183	Belongs to the thiolase family
E4K71_RS08075	COG0789	Transcriptional regulator
E4K71_RS08080	COG0318	PFAM AMP-dependent synthetase and ligase
E4K71_RS08105	COG0519	Catalyzes the synthesis of GMP from XMP
E4K71_RS08105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4K71_RS08110	COG0010	Belongs to the arginase family
E4K71_RS08115	COG1177	transmembrane transport
E4K71_RS08120	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4K71_RS08125	COG3842	ATPase activity
E4K71_RS08130	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4K71_RS08135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4K71_RS08140	COG0174	glutamine synthetase
E4K71_RS08150	COG1012	belongs to the aldehyde dehydrogenase family
E4K71_RS08155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4K71_RS08170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4K71_RS08280	COG4974	Belongs to the 'phage' integrase family
E4K71_RS08295	COG3328	transposase activity
E4K71_RS08300	COG3547	Transposase (IS116 IS110 IS902 family)
E4K71_RS08330	COG3676	manually curated
E4K71_RS08350	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
E4K71_RS08375	COG4974	Belongs to the 'phage' integrase family
E4K71_RS08400	COG4120	Belongs to the binding-protein-dependent transport system permease family
E4K71_RS08405	COG1132	(ABC) transporter
E4K71_RS08610	COG0482	sulfurtransferase activity
E4K71_RS08630	COG0443	Heat shock 70 kDa protein
E4K71_RS08635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4K71_RS08640	COG0316	Belongs to the HesB IscA family
E4K71_RS08645	COG0822	iron-sulfur transferase activity
E4K71_RS08650	COG1104	cysteine desulfurase activity
E4K71_RS08655	COG1104	cysteine desulfurase activity
E4K71_RS08660	COG1959	2 iron, 2 sulfur cluster binding
E4K71_RS08665	COG1045	serine acetyltransferase
E4K71_RS08670	COG2945	thiolester hydrolase activity
E4K71_RS08680	COG2095	MarC family integral membrane protein
E4K71_RS08695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4K71_RS08700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4K71_RS08710	COG2833	Protein of unknown function (DUF455)
E4K71_RS08715	COG0840	transmembrane signaling receptor activity
E4K71_RS08735	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4K71_RS08740	COG1530	ribonuclease E activity
E4K71_RS08745	COG0436	Aminotransferase
E4K71_RS08765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4K71_RS08765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4K71_RS08785	COG2183	response to ionizing radiation
E4K71_RS08790	COG0175	sulfate reduction
E4K71_RS08795	COG0400	carboxylic ester hydrolase activity
E4K71_RS08800	COG1366	Belongs to the anti-sigma-factor antagonist family
E4K71_RS08810	COG0784	Response regulator, receiver
E4K71_RS08815	COG0668	transmembrane transport
E4K71_RS08830	COG0745	RESPONSE REGULATOR receiver
E4K71_RS08840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4K71_RS08845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4K71_RS08895	COG0564	pseudouridine synthase activity
E4K71_RS08920	COG1054	Belongs to the UPF0176 family
E4K71_RS08930	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4K71_RS08935	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4K71_RS08950	COG2197	response regulator
E4K71_RS08955	COG0784	Response regulator, receiver
E4K71_RS08955	COG2205	protein histidine kinase activity
E4K71_RS08960	COG0793	Belongs to the peptidase S41A family
E4K71_RS08970	COG0730	response to heat
E4K71_RS08985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4K71_RS08985	COG0116	Belongs to the methyltransferase superfamily
E4K71_RS09000	COG1131	(ABC) transporter
E4K71_RS09055	COG0438	transferase activity, transferring glycosyl groups
E4K71_RS09120	COG1215	transferase activity, transferring glycosyl groups
E4K71_RS09125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4K71_RS09145	COG1596	polysaccharide export
E4K71_RS09155	COG2204	response regulator
E4K71_RS09170	COG2198	Histidine kinase
E4K71_RS09170	COG0784	Response regulator, receiver
E4K71_RS09170	COG5002	protein histidine kinase activity
E4K71_RS09175	COG0745	RESPONSE REGULATOR receiver
E4K71_RS09185	COG2205	protein histidine kinase activity
E4K71_RS09205	COG2414	aldehyde ferredoxin oxidoreductase
E4K71_RS09240	COG2205	protein histidine kinase activity
E4K71_RS09240	COG2198	Histidine kinase
E4K71_RS09240	COG0784	Response regulator, receiver
E4K71_RS09250	COG0535	radical SAM domain protein
E4K71_RS09265	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
E4K71_RS09285	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E4K71_RS09295	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
E4K71_RS09300	COG3259	Nickel-dependent hydrogenase
E4K71_RS09315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4K71_RS09320	COG0583	DNA-binding transcription factor activity
E4K71_RS09325	COG3676	manually curated
E4K71_RS09335	COG0642	Histidine kinase
E4K71_RS09360	COG2828	Protein conserved in bacteria
E4K71_RS09365	COG3180	Ammonia monooxygenase
E4K71_RS09375	COG1053	succinate dehydrogenase
E4K71_RS09380	COG1802	Transcriptional regulator
E4K71_RS09385	COG0604	alcohol dehydrogenase
E4K71_RS09385	COG3321	synthase
E4K71_RS09390	COG3958	Transketolase
E4K71_RS09395	COG3959	Transketolase, thiamine diphosphate binding domain
E4K71_RS09400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4K71_RS09410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E4K71_RS09415	COG0583	DNA-binding transcription factor activity
E4K71_RS09420	COG3959	Transketolase, thiamine diphosphate binding domain
E4K71_RS09425	COG3958	Transketolase
E4K71_RS09430	COG2084	Dehydrogenase
E4K71_RS09435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4K71_RS09455	COG0469	pyruvate kinase activity
E4K71_RS09490	COG0437	4 iron, 4 sulfur cluster binding
E4K71_RS09500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4K71_RS09505	COG2205	protein histidine kinase activity
E4K71_RS09505	COG0784	Response regulator, receiver
E4K71_RS09520	COG0745	RESPONSE REGULATOR receiver
E4K71_RS09555	COG4191	Histidine kinase
E4K71_RS09590	COG2703	oxygen carrier activity
E4K71_RS09605	COG2205	protein histidine kinase activity
E4K71_RS09605	COG0784	Response regulator, receiver
E4K71_RS09615	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4K71_RS09620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4K71_RS09625	COG0367	asparagine synthase
E4K71_RS09630	COG0438	transferase activity, transferring glycosyl groups
E4K71_RS09650	COG0354	folic acid binding
E4K71_RS09660	COG0733	neurotransmitter:sodium symporter activity
E4K71_RS09670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4K71_RS09670	COG0574	Belongs to the PEP-utilizing enzyme family
E4K71_RS09680	COG0752	glycyl-tRNA synthetase alpha subunit
E4K71_RS09710	COG0142	geranyltranstransferase activity
E4K71_RS09765	COG1396	sequence-specific DNA binding
E4K71_RS09780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4K71_RS09785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4K71_RS09790	COG0745	RESPONSE REGULATOR receiver
E4K71_RS09805	COG1744	ABC transporter substrate-binding protein PnrA-like
E4K71_RS09815	COG2132	Multicopper oxidase
E4K71_RS09845	COG5002	protein histidine kinase activity
E4K71_RS09845	COG2205	protein histidine kinase activity
E4K71_RS09845	COG0784	Response regulator, receiver
E4K71_RS09860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4K71_RS09865	COG0793	Belongs to the peptidase S41A family
E4K71_RS09870	COG0557	exoribonuclease II activity
E4K71_RS09875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4K71_RS09880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4K71_RS09880	COG0758	DNA mediated transformation
E4K71_RS09890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4K71_RS09895	COG0540	Belongs to the ATCase OTCase family
E4K71_RS09910	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4K71_RS09940	COG1561	YicC-like family, N-terminal region
E4K71_RS09965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4K71_RS09970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4K71_RS09985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4K71_RS09995	COG0640	Transcriptional regulator
E4K71_RS10000	COG0390	transport system, permease component
E4K71_RS10005	COG1116	anion transmembrane transporter activity
E4K71_RS10015	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4K71_RS10025	COG0359	binds to the 23S rRNA
E4K71_RS10035	COG0305	Participates in initiation and elongation during chromosome replication
E4K71_RS10040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4K71_RS10045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4K71_RS10050	COG1127	ABC transporter
E4K71_RS10065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4K71_RS10070	COG1028	Short-chain dehydrogenase reductase Sdr
E4K71_RS10090	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E4K71_RS10095	COG0745	RESPONSE REGULATOR receiver
E4K71_RS10125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4K71_RS10145	COG1355	regulation of microtubule-based process
E4K71_RS10150	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4K71_RS10160	COG3154	lipid carrier protein
E4K71_RS10165	COG0826	peptidase U32
E4K71_RS10175	COG0009	L-threonylcarbamoyladenylate synthase
E4K71_RS10180	COG0405	Gamma-glutamyltransferase
E4K71_RS10190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4K71_RS10250	COG3676	manually curated
E4K71_RS10275	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4K71_RS10280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4K71_RS10330	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4K71_RS10340	COG1012	belongs to the aldehyde dehydrogenase family
E4K71_RS10360	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4K71_RS10375	COG0410	ABC transporter
E4K71_RS10390	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4K71_RS10405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4K71_RS10440	COG0271	Belongs to the BolA IbaG family
E4K71_RS10455	COG2239	Acts as a magnesium transporter
E4K71_RS10460	COG4536	flavin adenine dinucleotide binding
E4K71_RS10465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4K71_RS10485	COG2301	Belongs to the HpcH HpaI aldolase family
E4K71_RS10490	COG3706	GGDEF domain
E4K71_RS10495	COG0659	secondary active sulfate transmembrane transporter activity
E4K71_RS10510	COG0167	dihydroorotate dehydrogenase activity
E4K71_RS10530	COG1160	GTP binding
E4K71_RS10535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4K71_RS10565	COG2207	Transcriptional regulator
E4K71_RS10595	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4K71_RS10600	COG1684	flagellar biosynthetic protein fliR
E4K71_RS10610	COG1677	Flagellar hook-basal body complex protein FliE
E4K71_RS10615	COG1558	bacterial-type flagellum-dependent cell motility
E4K71_RS10620	COG1815	bacterial-type flagellum-dependent cell motility
E4K71_RS10625	COG2257	FlhB HrpN YscU SpaS Family
E4K71_RS10640	COG1338	Plays a role in the flagellum-specific transport system
E4K71_RS10645	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E4K71_RS10650	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E4K71_RS10660	COG1360	Flagellar Motor Protein
E4K71_RS10715	COG4786	Flagellar basal body rod
E4K71_RS10720	COG4786	Flagellar basal body rod
E4K71_RS10725	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4K71_RS10730	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4K71_RS10735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4K71_RS10740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4K71_RS10750	COG4948	Mandelate Racemase Muconate Lactonizing
E4K71_RS10805	COG3210	domain, Protein
E4K71_RS10810	COG2831	hemolysin activation secretion protein
E4K71_RS10910	COG3676	manually curated
E4K71_RS10925	COG0071	Belongs to the small heat shock protein (HSP20) family
E4K71_RS10935	COG0254	rRNA binding
E4K71_RS10970	COG0483	inositol monophosphate 1-phosphatase activity
E4K71_RS10985	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E4K71_RS10990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4K71_RS11005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4K71_RS11030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4K71_RS11060	COG1530	ribonuclease E activity
E4K71_RS11065	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4K71_RS11130	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4K71_RS11145	COG1805	sodium ion transport
E4K71_RS11150	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4K71_RS11160	COG1477	protein flavinylation
E4K71_RS11195	COG2198	Histidine kinase
E4K71_RS11195	COG0643	Histidine kinase
E4K71_RS11205	COG0784	Response regulator, receiver
E4K71_RS11205	COG5002	protein histidine kinase activity
E4K71_RS11220	COG0688	phosphatidylethanolamine metabolic process
E4K71_RS11230	COG0784	Response regulator, receiver
E4K71_RS11230	COG2205	protein histidine kinase activity
E4K71_RS11250	COG2201	protein-glutamate methylesterase activity
E4K71_RS11260	COG0643	Histidine kinase
E4K71_RS11260	COG2198	Histidine kinase
E4K71_RS11270	COG2201	protein-glutamate methylesterase activity
E4K71_RS11300	COG4251	negative regulation of phosphorylation
E4K71_RS11300	COG3706	GGDEF domain
E4K71_RS11300	COG5001	Diguanylate cyclase
E4K71_RS11300	COG2203	Gaf domain
E4K71_RS11315	COG5002	protein histidine kinase activity
E4K71_RS11320	COG3706	GGDEF domain
E4K71_RS11320	COG4251	negative regulation of phosphorylation
E4K71_RS11320	COG5001	Diguanylate cyclase
E4K71_RS11320	COG2203	Gaf domain
E4K71_RS11360	COG0310	cobalt ion transport
E4K71_RS11395	COG0778	Nitroreductase
E4K71_RS11415	COG0625	glutathione transferase activity
E4K71_RS11430	COG0716	FMN binding
E4K71_RS11440	COG1024	Enoyl-CoA hydratase
E4K71_RS11445	COG1024	Enoyl-CoA hydratase
E4K71_RS11450	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4K71_RS11455	COG2050	protein possibly involved in aromatic compounds catabolism
E4K71_RS11460	COG0183	Belongs to the thiolase family
E4K71_RS11465	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E4K71_RS11500	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4K71_RS11520	COG3327	negative regulation of DNA-templated transcription, initiation
E4K71_RS11525	COG0493	'glutamate synthase
E4K71_RS11535	COG5002	protein histidine kinase activity
E4K71_RS11550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4K71_RS11565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4K71_RS11565	COG2813	Specifically methylates the guanine in position
E4K71_RS11570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4K71_RS11585	COG0287	Prephenate dehydrogenase
E4K71_RS11600	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4K71_RS11605	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4K71_RS11615	COG2900	Belongs to the SlyX family
E4K71_RS11625	COG2363	Small membrane protein
E4K71_RS11640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4K71_RS11640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4K71_RS11655	COG1131	(ABC) transporter
E4K71_RS11670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4K71_RS11710	COG1137	ATPase activity
E4K71_RS11715	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4K71_RS11720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4K71_RS11725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4K71_RS11740	COG2962	Rard protein
E4K71_RS11745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4K71_RS11750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4K71_RS11760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4K71_RS11785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4K71_RS11935	COG2204	response regulator
E4K71_RS11985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4K71_RS11990	COG0583	DNA-binding transcription factor activity
E4K71_RS11995	COG0492	ferredoxin-NADP+ reductase activity
E4K71_RS12000	COG0450	alkyl hydroperoxide reductase
E4K71_RS12005	COG1522	sequence-specific DNA binding
E4K71_RS12010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4K71_RS12015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4K71_RS12025	COG0505	Belongs to the CarA family
E4K71_RS12030	COG1610	YqeY-like protein
E4K71_RS12040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4K71_RS12075	COG3448	diguanylate cyclase activity
E4K71_RS12075	COG4175	Glycine betaine
E4K71_RS12080	COG4176	ABC-type proline glycine betaine transport system permease component
E4K71_RS12115	COG0785	Cytochrome C biogenesis protein
E4K71_RS12140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4K71_RS12150	COG3258	Cytochrome c
E4K71_RS12180	COG3005	denitrification pathway
E4K71_RS12185	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4K71_RS12190	COG2863	cytochrome
E4K71_RS12195	COG2202	Pas domain
E4K71_RS12195	COG2205	protein histidine kinase activity
E4K71_RS12200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4K71_RS12200	COG1199	ATP-dependent helicase activity
E4K71_RS12225	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4K71_RS12230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4K71_RS12235	COG0745	RESPONSE REGULATOR receiver
E4K71_RS12240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4K71_RS12280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4K71_RS12305	COG0071	Belongs to the small heat shock protein (HSP20) family
E4K71_RS12330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4K71_RS12335	COG0047	phosphoribosylformylglycinamidine synthase activity
E4K71_RS12340	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4K71_RS12345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4K71_RS12355	COG2801	Transposase and inactivated derivatives
E4K71_RS12365	COG3547	Transposase (IS116 IS110 IS902 family)
E4K71_RS12370	COG3328	transposase activity
E4K71_RS12380	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
E4K71_RS12385	COG2070	2-Nitropropane dioxygenase
E4K71_RS12390	COG0527	aspartate kinase activity
E4K71_RS12395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4K71_RS12410	COG3707	response regulator
E4K71_RS12420	COG4783	chaperone-mediated protein folding
E4K71_RS12425	COG2201	protein-glutamate methylesterase activity
E4K71_RS12430	COG0784	Response regulator, receiver
E4K71_RS12430	COG2198	Histidine kinase
E4K71_RS12430	COG0643	Histidine kinase
E4K71_RS12435	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4K71_RS12440	COG0004	ammonium transporteR
E4K71_RS12450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4K71_RS12465	COG2208	phosphoserine phosphatase activity
E4K71_RS12470	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4K71_RS12480	COG3676	manually curated
E4K71_RS12505	COG5642	Protein of unknown function (DUF2384)
E4K71_RS12510	COG3177	Filamentation induced by cAMP protein fic
E4K71_RS12540	COG3676	manually curated
E4K71_RS12555	COG2856	Zn peptidase
E4K71_RS12575	COG0583	DNA-binding transcription factor activity
E4K71_RS12580	COG0582	viral genome integration into host DNA
E4K71_RS12585	COG5642	Protein of unknown function (DUF2384)
E4K71_RS12590	COG3177	Filamentation induced by cAMP protein fic
E4K71_RS12605	COG3646	Phage regulatory protein
E4K71_RS12675	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4K71_RS12695	COG1051	belongs to the nudix hydrolase family
E4K71_RS12705	COG0793	Belongs to the peptidase S41A family
E4K71_RS12715	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4K71_RS12725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E4K71_RS12730	COG0799	negative regulation of ribosome biogenesis
E4K71_RS12740	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4K71_RS12745	COG2814	Major facilitator Superfamily
E4K71_RS12755	COG1216	Glycosyl transferase, family 2
E4K71_RS12775	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4K71_RS12780	COG0840	transmembrane signaling receptor activity
E4K71_RS12800	COG1032	radical SAM domain protein
E4K71_RS12815	COG0754	glutathionylspermidine amidase activity
E4K71_RS12855	COG1238	metal cluster binding
E4K71_RS12860	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4K71_RS12865	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E4K71_RS12880	COG0583	DNA-binding transcription factor activity
E4K71_RS12900	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4K71_RS12915	COG1028	Short-chain dehydrogenase reductase Sdr
E4K71_RS12920	COG2001	Belongs to the MraZ family
E4K71_RS12940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4K71_RS12970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4K71_RS12975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4K71_RS12980	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4K71_RS12985	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4K71_RS12990	COG0849	cell division
E4K71_RS12995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4K71_RS13005	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4K71_RS13010	COG0497	DNA recombination
E4K71_RS13015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4K71_RS13025	COG0519	Catalyzes the synthesis of GMP from XMP
E4K71_RS13045	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4K71_RS13065	COG2003	Belongs to the UPF0758 family
E4K71_RS13075	COG0840	transmembrane signaling receptor activity
E4K71_RS13080	COG0024	Methionine aminopeptidase
E4K71_RS13100	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4K71_RS13110	COG1196	nuclear chromosome segregation
E4K71_RS13115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4K71_RS13140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4K71_RS13145	COG0534	Mate efflux family protein
E4K71_RS13160	COG0308	aminopeptidase N
E4K71_RS13205	COG1067	ATP-dependent peptidase activity
E4K71_RS13210	COG2154	pterin-4-alpha-carbinolamine dehydratase
E4K71_RS13230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4K71_RS13235	COG1872	DUF167
E4K71_RS13250	COG1702	phosphate starvation-inducible protein PhoH
E4K71_RS13265	COG1703	isobutyryl-CoA mutase activity
E4K71_RS13275	COG0500	methyltransferase
E4K71_RS13280	COG3706	GGDEF domain
E4K71_RS13290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4K71_RS13290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4K71_RS13300	COG1643	Atp-dependent helicase
E4K71_RS13305	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4K71_RS13315	COG2197	response regulator
E4K71_RS13325	COG2081	HI0933 family
E4K71_RS13335	COG0686	Belongs to the AlaDH PNT family
E4K71_RS13340	COG1522	sequence-specific DNA binding
E4K71_RS13350	COG3383	formate dehydrogenase (NAD+) activity
E4K71_RS13360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4K71_RS13365	COG1960	acyl-CoA dehydrogenase activity
E4K71_RS13370	COG0583	DNA-binding transcription factor activity
E4K71_RS13375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4K71_RS13380	COG1846	Transcriptional regulator
E4K71_RS13385	COG0745	RESPONSE REGULATOR receiver
E4K71_RS13400	COG2099	Precorrin-6x reductase
E4K71_RS13405	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4K71_RS13420	COG1999	signal sequence binding
E4K71_RS13425	COG1797	cobyrinic acid a,c-diamide synthase activity
E4K71_RS13435	COG0617	tRNA 3'-terminal CCA addition
E4K71_RS13455	COG0714	Associated with various cellular activities
E4K71_RS13475	COG0583	DNA-binding transcription factor activity
E4K71_RS13480	COG0435	Glutathione S-transferase
E4K71_RS13485	COG3022	response to hydroperoxide
E4K71_RS13495	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E4K71_RS13515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4K71_RS13520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4K71_RS13525	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4K71_RS13525	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4K71_RS13535	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4K71_RS13540	COG2205	protein histidine kinase activity
E4K71_RS13545	COG0745	RESPONSE REGULATOR receiver
E4K71_RS13555	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E4K71_RS13565	COG2205	protein histidine kinase activity
E4K71_RS13585	COG1794	racemase activity, acting on amino acids and derivatives
E4K71_RS13590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4K71_RS13610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4K71_RS13615	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4K71_RS13620	COG0303	'Molybdopterin
E4K71_RS13625	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4K71_RS13630	COG0314	molybdopterin synthase activity
E4K71_RS13635	COG3676	manually curated
E4K71_RS13645	COG2119	membrane
E4K71_RS13665	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4K71_RS13670	COG1032	radical SAM domain protein
E4K71_RS13675	COG0546	phosphoglycolate phosphatase activity
E4K71_RS13685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4K71_RS13685	COG2205	protein histidine kinase activity
E4K71_RS13695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4K71_RS13760	COG3549	Plasmid maintenance system killer
E4K71_RS13780	COG3609	addiction module antidote protein, CC2985 family
E4K71_RS13850	COG0358	DNA primase activity
E4K71_RS13905	COG5002	protein histidine kinase activity
E4K71_RS13915	COG0772	Belongs to the SEDS family
E4K71_RS13920	COG0768	penicillin binding
E4K71_RS13950	COG0440	acetolactate synthase activity
E4K71_RS13955	COG0028	Belongs to the TPP enzyme family
E4K71_RS13960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4K71_RS13965	COG0560	Phosphoserine phosphatase
E4K71_RS13970	COG0288	reversible hydration of carbon dioxide
E4K71_RS13975	COG0242	peptide deformylase activity
E4K71_RS13980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4K71_RS13990	COG0101	tRNA pseudouridine synthase activity
E4K71_RS14005	COG0826	peptidase U32
E4K71_RS14010	COG3384	dioxygenase
E4K71_RS14020	COG1846	Transcriptional regulator
E4K71_RS14025	COG0432	Pfam Uncharacterised protein family UPF0047
E4K71_RS14035	COG0604	alcohol dehydrogenase
E4K71_RS14055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4K71_RS14070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4K71_RS14080	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4K71_RS14085	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4K71_RS14085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4K71_RS14160	COG4191	Histidine kinase
E4K71_RS14160	COG0784	Response regulator, receiver
E4K71_RS14175	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4K71_RS14180	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E4K71_RS14195	COG0589	response to stress
E4K71_RS14200	COG1051	belongs to the nudix hydrolase family
E4K71_RS14205	COG2954	triphosphatase activity
E4K71_RS14215	COG0840	transmembrane signaling receptor activity
E4K71_RS14215	COG3290	protein histidine kinase activity
E4K71_RS14220	COG0012	GTP binding
E4K71_RS14225	COG0193	aminoacyl-tRNA hydrolase activity
E4K71_RS14230	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4K71_RS14240	COG1674	ftsk spoiiie
E4K71_RS14270	COG1216	Glycosyl transferase, family 2
E4K71_RS14295	COG2902	Dehydrogenase
E4K71_RS14300	COG0454	-acetyltransferase
E4K71_RS14305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4K71_RS14325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4K71_RS14330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4K71_RS14360	COG1280	lysine exporter protein (LysE YggA)
E4K71_RS14370	COG0583	DNA-binding transcription factor activity
E4K71_RS14380	COG2391	methyltransferase activity
E4K71_RS14395	COG4235	cytochrome complex assembly
E4K71_RS14400	COG3088	subunit of a heme lyase
E4K71_RS14405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4K71_RS14410	COG1138	Cytochrome C-type biogenesis protein
E4K71_RS14415	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4K71_RS14425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4K71_RS14435	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4K71_RS14440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4K71_RS14480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4K71_RS14485	COG1396	sequence-specific DNA binding
E4K71_RS14490	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4K71_RS14495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4K71_RS14525	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4K71_RS14530	COG2301	Belongs to the HpcH HpaI aldolase family
E4K71_RS14545	COG4166	transmembrane transport
E4K71_RS14555	COG1678	Uncharacterized ACR, COG1678
E4K71_RS14565	COG0328	RNA-DNA hybrid ribonuclease activity
E4K71_RS14575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4K71_RS14595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4K71_RS14600	COG0509	glycine decarboxylation via glycine cleavage system
E4K71_RS14605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4K71_RS14610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4K71_RS14665	COG0735	belongs to the Fur family
E4K71_RS14690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4K71_RS14705	COG0277	FAD linked oxidase domain protein
E4K71_RS14710	COG1234	tRNA 3'-trailer cleavage
E4K71_RS14715	COG0488	(ABC) transporter
E4K71_RS14730	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4K71_RS14745	COG2030	dehydratase
E4K71_RS14755	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4K71_RS14760	COG0612	Peptidase, M16
E4K71_RS14765	COG0612	Peptidase, M16
E4K71_RS14775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4K71_RS14780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4K71_RS14785	COG0196	riboflavin kinase activity
E4K71_RS14790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4K71_RS14795	COG0302	gtp cyclohydrolase
E4K71_RS14815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4K71_RS14820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4K71_RS14825	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E4K71_RS14870	COG0285	dihydrofolate synthase activity
E4K71_RS14875	COG2918	glutathione biosynthetic process
E4K71_RS14875	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4K71_RS14880	COG0285	dihydrofolate synthase activity
E4K71_RS14885	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4K71_RS14895	COG0133	tryptophan synthase activity
E4K71_RS14920	COG0659	secondary active sulfate transmembrane transporter activity
E4K71_RS14925	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4K71_RS14950	COG4172	Belongs to the ABC transporter superfamily
E4K71_RS14955	COG4239	(ABC) transporter, permease
E4K71_RS14960	COG4174	ABC transporter (Permease)
E4K71_RS14990	COG0840	transmembrane signaling receptor activity
E4K71_RS14995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4K71_RS15005	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4K71_RS15025	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
E4K71_RS15030	COG1393	Belongs to the ArsC family
E4K71_RS15045	COG0019	diaminopimelate decarboxylase activity
E4K71_RS15050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E4K71_RS15065	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4K71_RS15065	COG0506	proline dehydrogenase activity
E4K71_RS15065	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4K71_RS15075	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4K71_RS15100	COG0697	spore germination
E4K71_RS15105	COG0477	Major facilitator Superfamily
E4K71_RS15120	COG0330	HflC and HflK could
E4K71_RS15125	COG0330	HflC and HflK could
E4K71_RS15130	COG0489	protein tyrosine kinase activity
E4K71_RS15140	COG0436	Aminotransferase
E4K71_RS15150	COG0745	RESPONSE REGULATOR receiver
E4K71_RS15155	COG2030	dehydratase
E4K71_RS15160	COG1192	Involved in chromosome partitioning
E4K71_RS15170	COG0708	Exodeoxyribonuclease III
E4K71_RS15180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4K71_RS15185	COG0137	argininosuccinate synthase activity
E4K71_RS15190	COG3300	MHYT domain
E4K71_RS15190	COG5001	Diguanylate cyclase
E4K71_RS15200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E4K71_RS15205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4K71_RS15215	COG0442	prolyl-tRNA aminoacylation
E4K71_RS15220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4K71_RS15220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4K71_RS15225	COG0604	alcohol dehydrogenase
E4K71_RS15235	COG2096	Adenosyltransferase
E4K71_RS15250	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4K71_RS15255	COG3676	manually curated
E4K71_RS15260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4K71_RS15290	COG2992	FlgJ-related protein
E4K71_RS15315	COG0280	phosphate acetyltransferase
E4K71_RS15315	COG0281	malic enzyme
E4K71_RS15325	COG0552	protein localization to endoplasmic reticulum
E4K71_RS15330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4K71_RS15335	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4K71_RS15385	COG2010	Cytochrome c
E4K71_RS15405	COG0405	Gamma-glutamyltransferase
E4K71_RS15410	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4K71_RS15415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4K71_RS15435	COG0398	Pfam SNARE associated Golgi protein
E4K71_RS15450	COG3118	belongs to the thioredoxin family
E4K71_RS15455	COG0842	Transport permease protein
E4K71_RS15460	COG2137	regulation of response to DNA damage stimulus
E4K71_RS15470	COG0006	proline dipeptidase activity
E4K71_RS15485	COG0583	DNA-binding transcription factor activity
E4K71_RS15510	COG1968	undecaprenyl-diphosphatase activity
E4K71_RS15530	COG1024	Enoyl-CoA hydratase
E4K71_RS15535	COG0606	chelatase, subunit chli
E4K71_RS15540	COG0513	Belongs to the DEAD box helicase family
E4K71_RS15570	COG2884	Cell division ATP-binding protein ftsE
E4K71_RS15600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4K71_RS15610	COG0697	spore germination
E4K71_RS15630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4K71_RS15645	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4K71_RS15650	COG0792	nuclease activity
E4K71_RS15665	COG0189	ligase activity
E4K71_RS15690	COG2211	Major facilitator Superfamily
E4K71_RS15695	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4K71_RS15705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4K71_RS15755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4K71_RS15780	COG3447	MASE1 domain protein
E4K71_RS15780	COG5002	protein histidine kinase activity
E4K71_RS15780	COG5001	Diguanylate cyclase
E4K71_RS15785	COG0443	Heat shock 70 kDa protein
E4K71_RS15795	COG0667	Aldo Keto reductase
E4K71_RS15800	COG0583	DNA-binding transcription factor activity
E4K71_RS15860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4K71_RS15875	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4K71_RS15895	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4K71_RS15900	COG1733	regulation of RNA biosynthetic process
E4K71_RS15905	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4K71_RS15910	COG0625	glutathione transferase activity
E4K71_RS15920	COG0745	RESPONSE REGULATOR receiver
E4K71_RS15940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4K71_RS15985	COG0583	DNA-binding transcription factor activity
E4K71_RS16025	COG1331	Highly conserved protein containing a thioredoxin domain
E4K71_RS16030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4K71_RS16040	COG1741	Belongs to the pirin family
E4K71_RS16050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4K71_RS16060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4K71_RS16070	COG1981	membrane
E4K71_RS16075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4K71_RS16090	COG0424	maF-like protein
E4K71_RS16100	COG0237	dephospho-CoA kinase activity
E4K71_RS16115	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E4K71_RS16120	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4K71_RS16130	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4K71_RS16150	COG0726	polysaccharide deacetylase
E4K71_RS16150	COG1649	PFAM Uncharacterised BCR, COG1649
E4K71_RS16160	COG1573	uracil-dna glycosylase
E4K71_RS16170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4K71_RS16180	COG3706	GGDEF domain
E4K71_RS16185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4K71_RS16195	COG1217	gtp-binding protein TYPA
E4K71_RS16220	COG1139	Iron-sulfur cluster binding protein
E4K71_RS16225	COG1556	Lactate utilization protein
E4K71_RS16235	COG1396	sequence-specific DNA binding
E4K71_RS16265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4K71_RS16275	COG1088	dTDP-glucose 4,6-dehydratase activity
E4K71_RS16280	COG1091	dTDP-4-dehydrorhamnose reductase activity
E4K71_RS16290	COG3415	Transposase
E4K71_RS16295	COG2826	transposase and inactivated derivatives, IS30 family
E4K71_RS16300	COG3676	manually curated
E4K71_RS16330	COG1083	cytidylyl-transferase
E4K71_RS16335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4K71_RS16345	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E4K71_RS16350	COG2089	acid synthase
E4K71_RS16355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4K71_RS16370	COG3415	Transposase
E4K71_RS16385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4K71_RS16385	COG0546	phosphoglycolate phosphatase activity
E4K71_RS16390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4K71_RS16395	COG0131	Imidazoleglycerol-phosphate dehydratase
E4K71_RS16400	COG0625	glutathione transferase activity
E4K71_RS16415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4K71_RS16420	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4K71_RS16450	COG0367	asparagine synthase
E4K71_RS16455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4K71_RS16470	COG2264	protein methyltransferase activity
E4K71_RS16475	COG0347	Belongs to the P(II) protein family
E4K71_RS16480	COG0004	ammonium transporteR
E4K71_RS16485	COG0004	ammonium transporteR
E4K71_RS16490	COG0175	sulfate reduction
E4K71_RS16515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4K71_RS16525	COG1088	dTDP-glucose 4,6-dehydratase activity
E4K71_RS16530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4K71_RS16555	COG1509	lysine 2,3-aminomutase activity
E4K71_RS16575	COG4310	Domain of unknown function (DUF2172)
E4K71_RS16595	COG2826	transposase and inactivated derivatives, IS30 family
E4K71_RS16605	COG2089	acid synthase
E4K71_RS16615	COG0438	transferase activity, transferring glycosyl groups
E4K71_RS16625	COG0367	asparagine synthase
E4K71_RS16640	COG1083	cytidylyl-transferase
E4K71_RS16655	COG2089	acid synthase
E4K71_RS16680	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4K71_RS16690	COG1086	Polysaccharide biosynthesis protein
E4K71_RS16710	COG1132	(ABC) transporter
E4K71_RS16720	COG1083	cytidylyl-transferase
E4K71_RS16730	COG0107	imidazoleglycerol-phosphate synthase activity
E4K71_RS16770	COG0438	transferase activity, transferring glycosyl groups
E4K71_RS16775	COG3307	-O-antigen
E4K71_RS16810	COG0501	Belongs to the peptidase M48B family
E4K71_RS16815	COG3453	Protein conserved in bacteria
E4K71_RS16815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4K71_RS16825	COG0438	transferase activity, transferring glycosyl groups
E4K71_RS16840	COG0138	bifunctional purine biosynthesis protein purh
E4K71_RS16855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4K71_RS16875	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4K71_RS16880	COG2192	nodulation
E4K71_RS16890	COG1696	Membrane protein involved in D-alanine export
E4K71_RS16905	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
E4K71_RS16925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4K71_RS16930	COG0181	hydroxymethylbilane synthase activity
E4K71_RS16950	COG3845	ABC transporter
E4K71_RS16960	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4K71_RS16995	COG0745	RESPONSE REGULATOR receiver
E4K71_RS17010	COG0670	Belongs to the BI1 family
E4K71_RS17015	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4K71_RS17020	COG4181	ATPase activity
E4K71_RS17030	COG0667	Aldo Keto reductase
E4K71_RS17035	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E4K71_RS17045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4K71_RS17050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4K71_RS17070	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E4K71_RS17115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4K71_RS17120	COG1253	flavin adenine dinucleotide binding
E4K71_RS17130	COG0728	peptidoglycan biosynthetic process
E4K71_RS17135	COG0840	transmembrane signaling receptor activity
E4K71_RS17140	COG0180	Tryptophanyl-tRNA synthetase
E4K71_RS17155	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4K71_RS17170	COG0312	modulator of DNA gyrase
E4K71_RS17175	COG1132	(ABC) transporter
E4K71_RS17185	COG1519	Transferase
E4K71_RS17210	COG1570	exodeoxyribonuclease VII activity
E4K71_RS17230	COG0463	Glycosyl transferase, family 2
E4K71_RS17240	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4K71_RS17245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4K71_RS17275	COG0612	Peptidase, M16
E4K71_RS17285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4K71_RS17290	COG2171	N-acyltransferase activity
E4K71_RS17295	COG0840	transmembrane signaling receptor activity
E4K71_RS17305	COG1047	Peptidyl-prolyl cis-trans
E4K71_RS17340	COG2835	tetraacyldisaccharide 4'-kinase activity
E4K71_RS17355	COG0697	spore germination
E4K71_RS17360	COG2983	Belongs to the UPF0260 family
E4K71_RS17370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4K71_RS17380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4K71_RS17385	COG0706	membrane insertase activity
E4K71_RS17390	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4K71_RS17395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4K71_RS17410	COG0741	lytic transglycosylase activity
E4K71_RS17415	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4K71_RS17435	COG4221	oxidoreductase activity
E4K71_RS17445	COG0473	3-isopropylmalate dehydrogenase activity
E4K71_RS17455	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4K71_RS17465	COG2932	Transcriptional regulator
E4K71_RS17480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4K71_RS17485	COG0228	four-way junction DNA binding
E4K71_RS17490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4K71_RS17515	COG1396	sequence-specific DNA binding
E4K71_RS17520	COG1396	sequence-specific DNA binding
E4K71_RS17530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4K71_RS17550	COG0312	modulator of DNA gyrase
E4K71_RS17580	COG2200	EAL domain
E4K71_RS17590	COG0742	ribosomal rna small subunit methyltransferase
E4K71_RS17595	COG1187	pseudouridine synthase activity
E4K71_RS17600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4K71_RS17605	COG0590	tRNA wobble adenosine to inosine editing
E4K71_RS17630	COG0840	transmembrane signaling receptor activity
E4K71_RS17635	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4K71_RS17640	COG0039	L-malate dehydrogenase activity
E4K71_RS17645	COG0045	succinate-CoA ligase (ADP-forming) activity
E4K71_RS17660	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4K71_RS17665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4K71_RS17675	COG0745	RESPONSE REGULATOR receiver
E4K71_RS17715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4K71_RS17740	COG0745	RESPONSE REGULATOR receiver
E4K71_RS17745	COG4251	negative regulation of phosphorylation
E4K71_RS17760	COG2814	Major facilitator Superfamily
E4K71_RS17775	COG0166	Belongs to the GPI family
E4K71_RS17780	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4K71_RS17790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4K71_RS17795	COG2010	Cytochrome c
E4K71_RS17800	COG0784	Response regulator, receiver
E4K71_RS17800	COG2205	protein histidine kinase activity
E4K71_RS17835	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4K71_RS17850	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4K71_RS17850	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4K71_RS17870	COG0427	acetyl-CoA hydrolase
E4K71_RS17905	COG3676	manually curated
E4K71_RS17915	COG2824	Alkylphosphonate utilization operon protein PhnA
E4K71_RS17965	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4K71_RS17995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4K71_RS17995	COG4797	methyltransferase
E4K71_RS18020	COG2205	protein histidine kinase activity
E4K71_RS18020	COG0784	Response regulator, receiver
E4K71_RS18030	COG2814	Major facilitator Superfamily
E4K71_RS18040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4K71_RS18045	COG0840	transmembrane signaling receptor activity
E4K71_RS18045	COG0840	transmembrane signaling receptor activity
E4K71_RS18055	COG1959	2 iron, 2 sulfur cluster binding
E4K71_RS18060	COG0756	dUTP diphosphatase activity
E4K71_RS18065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4K71_RS18070	COG1028	Short-chain dehydrogenase reductase Sdr
E4K71_RS18075	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4K71_RS18080	COG2226	methyltransferase
E4K71_RS18085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4K71_RS18095	COG1024	Enoyl-CoA hydratase
E4K71_RS18100	COG0268	Binds directly to 16S ribosomal RNA