locus-tag	class	description
H5715_RS00005	COG1012	belongs to the aldehyde dehydrogenase family
H5715_RS00005	COG1454	alcohol dehydrogenase
H5715_RS00010	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS00035	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H5715_RS00050	COG0632	four-way junction helicase activity
H5715_RS00055	COG2255	four-way junction helicase activity
H5715_RS00060	COG0824	Thioesterase
H5715_RS00080	COG0823	Involved in the tonB-independent uptake of proteins
H5715_RS00090	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H5715_RS00095	COG0602	queuosine metabolic process
H5715_RS00100	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H5715_RS00110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H5715_RS00115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5715_RS00125	COG0456	acetyltransferase
H5715_RS00135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H5715_RS00145	COG0628	permease
H5715_RS00175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5715_RS00190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5715_RS00195	COG0848	biopolymer transport protein
H5715_RS00200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5715_RS00200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5715_RS00210	COG0494	nUDIX hydrolase
H5715_RS00230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H5715_RS00235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5715_RS00240	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H5715_RS00250	COG1115	amino acid carrier protein
H5715_RS00330	COG3661	Belongs to the glycosyl hydrolase 67 family
H5715_RS00335	COG1472	Belongs to the glycosyl hydrolase 3 family
H5715_RS00355	COG2223	nitrite transmembrane transporter activity
H5715_RS00360	COG0840	transmembrane signaling receptor activity
H5715_RS00365	COG0737	Belongs to the 5'-nucleotidase family
H5715_RS00455	COG1196	nuclear chromosome segregation
H5715_RS00460	COG2304	oxidoreductase activity
H5715_RS00465	COG3507	Belongs to the glycosyl hydrolase 43 family
H5715_RS00470	COG2755	lipolytic protein G-D-S-L family
H5715_RS00505	COG0210	DNA helicase
H5715_RS00515	COG2304	oxidoreductase activity
H5715_RS00525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5715_RS00550	COG0667	Aldo Keto reductase
H5715_RS00555	COG3693	PFAM glycoside hydrolase, family 10
H5715_RS00570	COG2307	Protein conserved in bacteria
H5715_RS00570	COG2308	Evidence 4 Homologs of previously reported genes of
H5715_RS00585	COG2308	Evidence 4 Homologs of previously reported genes of
H5715_RS00635	COG4772	TonB-dependent receptor
H5715_RS00650	COG3842	ATPase activity
H5715_RS00655	COG1178	ABC-type Fe3 transport system permease component
H5715_RS00660	COG1840	ABC-type Fe3 transport system, periplasmic component
H5715_RS00665	COG2815	serine threonine protein kinase
H5715_RS00665	COG0515	serine threonine protein kinase
H5715_RS00670	COG2205	protein histidine kinase activity
H5715_RS00670	COG0784	Response regulator, receiver
H5715_RS00675	COG2906	2 iron, 2 sulfur cluster binding
H5715_RS00680	COG0450	alkyl hydroperoxide reductase
H5715_RS00690	COG0442	prolyl-tRNA aminoacylation
H5715_RS00700	COG0776	regulation of translation
H5715_RS00710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H5715_RS00715	COG0217	transcriptional regulatory protein
H5715_RS00720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5715_RS00725	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H5715_RS00725	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H5715_RS00730	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H5715_RS00775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H5715_RS00780	COG0081	regulation of translation
H5715_RS00785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H5715_RS00790	COG0222	ribosome binding
H5715_RS00795	COG0085	RNA polymerase activity
H5715_RS00800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H5715_RS00805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H5715_RS00810	COG0049	tRNA binding
H5715_RS00815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H5715_RS00820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H5715_RS00830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H5715_RS00840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5715_RS00845	COG2186	Transcriptional regulator
H5715_RS00850	COG0800	Aldolase
H5715_RS00855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5715_RS00860	COG0246	Mannitol dehydrogenase
H5715_RS00915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5715_RS00920	COG1757	Na H antiporter
H5715_RS00935	COG1472	Belongs to the glycosyl hydrolase 3 family
H5715_RS00940	COG0513	Belongs to the DEAD box helicase family
H5715_RS00945	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS00980	COG0051	transcription antitermination factor activity, RNA binding
H5715_RS00985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H5715_RS00990	COG0088	Forms part of the polypeptide exit tunnel
H5715_RS00995	COG0089	rRNA binding
H5715_RS01000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H5715_RS01005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H5715_RS01010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H5715_RS01015	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H5715_RS01020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H5715_RS01025	COG0255	Belongs to the universal ribosomal protein uL29 family
H5715_RS01030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H5715_RS01035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H5715_RS01040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H5715_RS01045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H5715_RS01050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H5715_RS01055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H5715_RS01060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H5715_RS01065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H5715_RS01070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H5715_RS01075	COG1841	ribosomal large subunit assembly
H5715_RS01080	COG0200	Binds to the 23S rRNA
H5715_RS01090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H5715_RS01095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H5715_RS01100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H5715_RS01105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H5715_RS01110	COG0202	RNA polymerase activity
H5715_RS01115	COG0203	ribosomal protein L17
H5715_RS01120	COG1640	4-alpha-glucanotransferase
H5715_RS01125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H5715_RS01135	COG0058	SHG alpha-glucan phosphorylase activity
H5715_RS01140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H5715_RS01145	COG0297	glycogen (starch) synthase activity
H5715_RS01155	COG2197	response regulator
H5715_RS01160	COG2814	Major facilitator Superfamily
H5715_RS01180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5715_RS01195	COG2259	Doxx family
H5715_RS01205	COG3220	belongs to the UPF0276 family
H5715_RS01215	COG2197	response regulator
H5715_RS01325	COG0166	Belongs to the GPI family
H5715_RS01330	COG0142	geranyltranstransferase activity
H5715_RS01340	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H5715_RS01345	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H5715_RS01350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H5715_RS01355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H5715_RS01360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H5715_RS01365	COG0268	Binds directly to 16S ribosomal RNA
H5715_RS01375	COG0745	RESPONSE REGULATOR receiver
H5715_RS01390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5715_RS01395	COG1131	(ABC) transporter
H5715_RS01400	COG0842	Transport permease protein
H5715_RS01405	COG3122	Protein conserved in bacteria
H5715_RS01410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS01430	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H5715_RS01435	COG0667	Aldo Keto reductase
H5715_RS01440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5715_RS01450	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H5715_RS01475	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H5715_RS01490	COG1355	regulation of microtubule-based process
H5715_RS01500	COG1278	Cold shock
H5715_RS01525	COG1904	glucuronate isomerase
H5715_RS01530	COG2721	sulfolactate sulfo-lyase activity
H5715_RS01550	COG0151	Belongs to the GarS family
H5715_RS01555	COG0138	bifunctional purine biosynthesis protein purh
H5715_RS01575	COG2264	protein methyltransferase activity
H5715_RS01585	COG0511	ligase activity, forming carbon-carbon bonds
H5715_RS01590	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H5715_RS01595	COG4232	protein-disulfide reductase activity
H5715_RS01615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5715_RS01630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H5715_RS01640	COG1981	membrane
H5715_RS01650	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H5715_RS01665	COG0316	Belongs to the HesB IscA family
H5715_RS01680	COG0784	Response regulator, receiver
H5715_RS01680	COG2205	protein histidine kinase activity
H5715_RS01680	COG5002	protein histidine kinase activity
H5715_RS01685	COG2001	Belongs to the MraZ family
H5715_RS01690	COG0275	rRNA processing
H5715_RS01705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H5715_RS01710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H5715_RS01715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H5715_RS01720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H5715_RS01725	COG0772	Belongs to the SEDS family
H5715_RS01735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5715_RS01740	COG1181	Belongs to the D-alanine--D-alanine ligase family
H5715_RS01745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H5715_RS01760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H5715_RS01765	COG0739	heme binding
H5715_RS01770	COG0653	protein targeting
H5715_RS01775	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H5715_RS01780	COG0494	nUDIX hydrolase
H5715_RS01790	COG0237	dephospho-CoA kinase activity
H5715_RS01795	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H5715_RS01835	COG0463	Glycosyl transferase, family 2
H5715_RS01845	COG0297	glycogen (starch) synthase activity
H5715_RS01855	COG3577	Aspartyl protease
H5715_RS01875	COG2211	Major facilitator Superfamily
H5715_RS01880	COG3030	protein affecting phage T7 exclusion by the F plasmid
H5715_RS01885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H5715_RS01890	COG0459	protein refolding
H5715_RS01895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H5715_RS01930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H5715_RS01935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H5715_RS01945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H5715_RS01950	COG0616	signal peptide processing
H5715_RS01965	COG1393	Belongs to the ArsC family
H5715_RS01970	COG1295	ribonuclease BN
H5715_RS01975	COG3437	response regulator, receiver
H5715_RS01980	COG3977	Valine--pyruvate aminotransferase
H5715_RS01985	COG3265	gluconokinase activity
H5715_RS01990	COG1609	Transcriptional regulator
H5715_RS01995	COG2211	Major facilitator Superfamily
H5715_RS02000	COG3459	Glycosyltransferase 36 associated
H5715_RS02015	COG0463	Glycosyl transferase, family 2
H5715_RS02030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5715_RS02035	COG0418	dihydroorotase activity
H5715_RS02045	COG0390	transport system, permease component
H5715_RS02050	COG0137	argininosuccinate synthase activity
H5715_RS02055	COG3278	Belongs to the heme-copper respiratory oxidase family
H5715_RS02070	COG2010	Cytochrome c
H5715_RS02085	COG2217	Heavy metal translocating P-type atpase
H5715_RS02100	COG0693	protein deglycase activity
H5715_RS02135	COG0346	lactoylglutathione lyase activity
H5715_RS02140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5715_RS02140	COG0512	Glutamine amidotransferase of anthranilate synthase
H5715_RS02150	COG4660	Part of a membrane complex involved in electron transport
H5715_RS02155	COG4659	FMN binding
H5715_RS02160	COG4658	electron transport chain
H5715_RS02165	COG4656	Part of a membrane complex involved in electron transport
H5715_RS02170	COG2878	Part of a membrane complex involved in electron transport
H5715_RS02175	COG4657	Part of a membrane complex involved in electron transport
H5715_RS02180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5715_RS02180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5715_RS02185	COG0489	protein tyrosine kinase activity
H5715_RS02190	COG0717	Belongs to the dCTP deaminase family
H5715_RS02195	COG0288	reversible hydration of carbon dioxide
H5715_RS02200	COG2925	Exonuclease
H5715_RS02210	COG0540	Belongs to the ATCase OTCase family
H5715_RS02230	COG1199	ATP-dependent helicase activity
H5715_RS02235	COG3098	single-species biofilm formation
H5715_RS02240	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H5715_RS02245	COG0018	arginyl-trna synthetase
H5715_RS02250	COG1024	Enoyl-CoA hydratase
H5715_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS02270	COG0247	lactate metabolic process
H5715_RS02270	COG0277	FAD linked oxidase domain protein
H5715_RS02285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5715_RS02285	COG1648	precorrin-2 dehydrogenase activity
H5715_RS02290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5715_RS02300	COG0243	molybdopterin cofactor binding
H5715_RS02305	COG0437	4 iron, 4 sulfur cluster binding
H5715_RS02315	COG2205	protein histidine kinase activity
H5715_RS02315	COG2202	Pas domain
H5715_RS02320	COG0784	Response regulator, receiver
H5715_RS02335	COG3639	organic phosphonate transmembrane transporter activity
H5715_RS02340	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H5715_RS02345	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H5715_RS02350	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H5715_RS02370	COG0243	molybdopterin cofactor binding
H5715_RS02375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5715_RS02380	COG2205	protein histidine kinase activity
H5715_RS02385	COG0745	RESPONSE REGULATOR receiver
H5715_RS02390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5715_RS02395	COG0640	Transcriptional regulator
H5715_RS02400	COG0840	transmembrane signaling receptor activity
H5715_RS02410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5715_RS02420	COG0837	glucose binding
H5715_RS02425	COG1472	Belongs to the glycosyl hydrolase 3 family
H5715_RS02430	COG0587	DNA-directed DNA polymerase activity
H5715_RS02475	COG3344	reverse transcriptase
H5715_RS02510	COG1136	(ABC) transporter
H5715_RS02515	COG0577	efflux transmembrane transporter activity
H5715_RS02545	COG1215	transferase activity, transferring glycosyl groups
H5715_RS02545	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H5715_RS02575	COG1132	(ABC) transporter
H5715_RS02630	COG2200	EAL domain
H5715_RS02655	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H5715_RS02660	COG1940	carbohydrate kinase activity
H5715_RS02670	COG0671	phosphoesterase, PA-phosphatase related
H5715_RS02680	COG2885	chlorophyll binding
H5715_RS02680	COG3047	cAMP biosynthetic process
H5715_RS02685	COG2274	protein secretion by the type I secretion system
H5715_RS02695	COG2197	response regulator
H5715_RS02830	COG3034	peptidoglycan biosynthetic process
H5715_RS02950	COG0515	serine threonine protein kinase
H5715_RS02950	COG2815	serine threonine protein kinase
H5715_RS02955	COG2223	nitrite transmembrane transporter activity
H5715_RS02965	COG3706	GGDEF domain
H5715_RS02970	COG0640	Transcriptional regulator
H5715_RS02990	COG4771	TonB-dependent receptor
H5715_RS02995	COG2207	Transcriptional regulator
H5715_RS03005	COG5297	Belongs to the glycosyl hydrolase family 6
H5715_RS03015	COG5297	Belongs to the glycosyl hydrolase family 6
H5715_RS03020	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS03025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS03040	COG2354	Protein conserved in bacteria
H5715_RS03075	COG0259	pyridoxamine-phosphate oxidase activity
H5715_RS03085	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H5715_RS03090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H5715_RS03095	COG1522	sequence-specific DNA binding
H5715_RS03100	COG1448	Aminotransferase
H5715_RS03115	COG0419	ATPase involved in DNA repair
H5715_RS03120	COG0420	3'-5' exonuclease activity
H5715_RS03130	COG0037	tRNA processing
H5715_RS03135	COG0504	CTP synthase activity
H5715_RS03140	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H5715_RS03145	COG0148	phosphopyruvate hydratase activity
H5715_RS03170	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H5715_RS03175	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS03190	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H5715_RS03195	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H5715_RS03200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H5715_RS03205	COG0585	pseudouridine synthase activity
H5715_RS03210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H5715_RS03230	COG0708	Exodeoxyribonuclease III
H5715_RS03235	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H5715_RS03240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H5715_RS03245	COG3706	GGDEF domain
H5715_RS03255	COG1546	Belongs to the CinA family
H5715_RS03260	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H5715_RS03265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H5715_RS03290	COG2137	regulation of response to DNA damage stimulus
H5715_RS03350	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5715_RS03360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5715_RS03360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5715_RS03425	COG2217	Heavy metal translocating P-type atpase
H5715_RS03465	COG0058	SHG alpha-glucan phosphorylase activity
H5715_RS03475	COG0723	plastoquinol--plastocyanin reductase activity
H5715_RS03500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5715_RS03505	COG1252	NADH dehydrogenase
H5715_RS03520	COG0697	spore germination
H5715_RS03545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5715_RS03545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5715_RS03630	COG0789	Transcriptional regulator
H5715_RS03700	COG4124	Belongs to the glycosyl hydrolase 26 family
H5715_RS03710	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS03750	COG2835	tetraacyldisaccharide 4'-kinase activity
H5715_RS03755	COG0537	adenosine 5'-monophosphoramidase activity
H5715_RS03760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H5715_RS03765	COG0527	aspartate kinase activity
H5715_RS03770	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H5715_RS03835	COG0754	glutathionylspermidine amidase activity
H5715_RS03840	COG5463	Belongs to the UPF0441 family
H5715_RS03860	COG1842	Phage shock protein A
H5715_RS03905	COG3509	depolymerase
H5715_RS03930	COG1803	Methylglyoxal synthase
H5715_RS03935	COG0405	Gamma-glutamyltransferase
H5715_RS03950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5715_RS03955	COG3630	sodium ion export across plasma membrane
H5715_RS03960	COG5016	pyruvate
H5715_RS03960	COG0511	ligase activity, forming carbon-carbon bonds
H5715_RS03965	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H5715_RS03970	COG0469	pyruvate kinase activity
H5715_RS03980	COG0271	Belongs to the BolA IbaG family
H5715_RS03985	COG1739	Uncharacterized protein family UPF0029
H5715_RS04000	COG1842	Phage shock protein A
H5715_RS04010	COG1983	PspC domain protein
H5715_RS04020	COG1011	Hydrolase
H5715_RS04040	COG2211	Major facilitator Superfamily
H5715_RS04050	COG3459	Glycosyltransferase 36 associated
H5715_RS04065	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS04070	COG3243	poly(R)-hydroxyalkanoic acid synthase
H5715_RS04075	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H5715_RS04090	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS04095	COG3118	belongs to the thioredoxin family
H5715_RS04105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5715_RS04120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H5715_RS04125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H5715_RS04135	COG3100	YcgL domain-containing protein
H5715_RS04140	COG2983	Belongs to the UPF0260 family
H5715_RS04145	COG2900	Belongs to the SlyX family
H5715_RS04170	COG1242	4 iron, 4 sulfur cluster binding
H5715_RS04375	COG0515	serine threonine protein kinase
H5715_RS04415	COG0488	(ABC) transporter
H5715_RS04420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H5715_RS04430	COG0326	Molecular chaperone. Has ATPase activity
H5715_RS04435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H5715_RS04445	COG2062	phosphohistidine phosphatase, SixA
H5715_RS04460	COG0302	gtp cyclohydrolase
H5715_RS04470	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H5715_RS04475	COG2814	Major facilitator Superfamily
H5715_RS04495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H5715_RS04500	COG0066	3-isopropylmalate dehydratase activity
H5715_RS04505	COG0473	3-isopropylmalate dehydrogenase activity
H5715_RS04535	COG0159	tryptophan synthase activity
H5715_RS04540	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H5715_RS04545	COG0285	dihydrofolate synthase activity
H5715_RS04565	COG1286	toxin biosynthetic process
H5715_RS04585	COG0714	Associated with various cellular activities
H5715_RS04600	COG0004	ammonium transporteR
H5715_RS04610	COG1584	GPR1 FUN34 yaaH family protein
H5715_RS04615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5715_RS04620	COG0516	GMP reductase activity
H5715_RS04620	COG0517	IMP dehydrogenase activity
H5715_RS04625	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H5715_RS04630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5715_RS04640	COG2350	Protein conserved in bacteria
H5715_RS04650	COG0613	PHP domain protein
H5715_RS04655	COG0009	L-threonylcarbamoyladenylate synthase
H5715_RS04665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H5715_RS04690	COG0500	methyltransferase
H5715_RS04695	COG4106	trans-aconitate 2-methyltransferase activity
H5715_RS04705	COG5002	protein histidine kinase activity
H5715_RS04730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H5715_RS04735	COG0542	response to heat
H5715_RS04740	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H5715_RS04745	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H5715_RS04750	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H5715_RS04755	COG0492	ferredoxin-NADP+ reductase activity
H5715_RS04765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H5715_RS04770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H5715_RS04775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H5715_RS04780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H5715_RS04785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5715_RS04785	COG1648	precorrin-2 dehydrogenase activity
H5715_RS04810	COG3318	Belongs to the UPF0149 family
H5715_RS04810	COG3012	SEC-C Motif Domain Protein
H5715_RS04815	COG0656	L-ascorbic acid biosynthetic process
H5715_RS04835	COG3693	PFAM glycoside hydrolase, family 10
H5715_RS04845	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS04875	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H5715_RS04910	COG0714	Associated with various cellular activities
H5715_RS04920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H5715_RS04925	COG0513	Belongs to the DEAD box helicase family
H5715_RS04945	COG1131	(ABC) transporter
H5715_RS04965	COG1053	succinate dehydrogenase
H5715_RS04990	COG0045	succinate-CoA ligase (ADP-forming) activity
H5715_RS05010	COG3104	oligopeptide transport
H5715_RS05015	COG4172	Belongs to the ABC transporter superfamily
H5715_RS05020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5715_RS05025	COG0601	transmembrane transport
H5715_RS05045	COG1388	LysM domain
H5715_RS05045	COG0741	lytic transglycosylase activity
H5715_RS05050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5715_RS05055	COG2226	methyltransferase
H5715_RS05065	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5715_RS05075	COG2816	NAD+ diphosphatase activity
H5715_RS05085	COG0616	signal peptide processing
H5715_RS05090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5715_RS05090	COG0475	glutathione-regulated potassium exporter activity
H5715_RS05100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5715_RS05120	COG0316	Belongs to the HesB IscA family
H5715_RS05120	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H5715_RS05130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5715_RS05180	COG0708	Exodeoxyribonuclease III
H5715_RS05195	COG1309	transcriptional regulator
H5715_RS05205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5715_RS05330	COG4115	mRNA cleavage
H5715_RS05410	COG3034	peptidoglycan biosynthetic process
H5715_RS05445	COG3547	Transposase (IS116 IS110 IS902 family)
H5715_RS05465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5715_RS05485	COG0300	oxidoreductase activity
H5715_RS05485	COG4221	oxidoreductase activity
H5715_RS05485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5715_RS05485	COG3321	synthase
H5715_RS05490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5715_RS05495	COG0156	8-amino-7-oxononanoate synthase activity
H5715_RS05505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H5715_RS05535	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5715_RS05555	COG4615	Cyclic peptide transporter
H5715_RS05565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5715_RS05620	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H5715_RS05640	COG0545	Peptidyl-prolyl cis-trans isomerase
H5715_RS05645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H5715_RS05665	COG4974	Belongs to the 'phage' integrase family
H5715_RS05775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5715_RS05780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5715_RS05780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H5715_RS05850	COG0556	nucleotide-excision repair
H5715_RS05855	COG0116	Belongs to the methyltransferase superfamily
H5715_RS05855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H5715_RS05860	COG3130	regulation of translation
H5715_RS05865	COG0167	dihydroorotate dehydrogenase activity
H5715_RS05880	COG0714	Associated with various cellular activities
H5715_RS05910	COG2353	YceI-like domain
H5715_RS05920	COG0308	aminopeptidase N
H5715_RS05935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H5715_RS05940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H5715_RS05975	COG3852	Histidine kinase
H5715_RS05980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5715_RS06005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H5715_RS06010	COG1187	pseudouridine synthase activity
H5715_RS06015	COG2813	Specifically methylates the guanine in position
H5715_RS06035	COG0564	pseudouridine synthase activity
H5715_RS06055	COG0300	oxidoreductase activity
H5715_RS06065	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H5715_RS06075	COG0784	Response regulator, receiver
H5715_RS06075	COG2205	protein histidine kinase activity
H5715_RS06080	COG0484	heat shock protein binding
H5715_RS06095	COG0215	cysteine-tRNA ligase activity
H5715_RS06100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5715_RS06110	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5715_RS06120	COG2205	protein histidine kinase activity
H5715_RS06120	COG2202	Pas domain
H5715_RS06185	COG0330	HflC and HflK could
H5715_RS06190	COG0318	PFAM AMP-dependent synthetase and ligase
H5715_RS06195	COG1960	acyl-CoA dehydrogenase activity
H5715_RS06225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H5715_RS06230	COG3115	cell septum assembly
H5715_RS06275	COG3509	depolymerase
H5715_RS06275	COG3693	PFAM glycoside hydrolase, family 10
H5715_RS06305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5715_RS06345	COG1309	transcriptional regulator
H5715_RS06360	COG3214	Protein conserved in bacteria
H5715_RS06410	COG4771	TonB-dependent receptor
H5715_RS06535	COG0322	excinuclease ABC activity
H5715_RS06560	COG0842	Transport permease protein
H5715_RS06560	COG1131	(ABC) transporter
H5715_RS06560	COG1716	ATPase activity
H5715_RS06575	COG0463	Glycosyl transferase, family 2
H5715_RS06580	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H5715_RS06585	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H5715_RS06590	COG0671	phosphoesterase, PA-phosphatase related
H5715_RS06595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5715_RS06600	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H5715_RS06605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5715_RS06610	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H5715_RS06655	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H5715_RS06670	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5715_RS06675	COG4133	protoheme IX ABC transporter activity
H5715_RS06690	COG3123	guanosine phosphorylase activity
H5715_RS06695	COG2205	protein histidine kinase activity
H5715_RS06695	COG2202	Pas domain
H5715_RS06715	COG3345	alpha-galactosidase
H5715_RS06740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5715_RS06765	COG1472	Belongs to the glycosyl hydrolase 3 family
H5715_RS06770	COG3250	beta-galactosidase activity
H5715_RS06810	COG2832	Protein of unknown function (DUF454)
H5715_RS06820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H5715_RS06845	COG0795	lipopolysaccharide-transporting ATPase activity
H5715_RS06850	COG0795	lipopolysaccharide-transporting ATPase activity
H5715_RS06855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H5715_RS06870	COG0525	valine-tRNA ligase activity
H5715_RS06895	COG2897	thiosulfate sulfurtransferase activity
H5715_RS06910	COG1278	Cold shock
H5715_RS06915	COG0529	Catalyzes the synthesis of activated sulfate
H5715_RS06930	COG2703	oxygen carrier activity
H5715_RS06940	COG0826	peptidase U32
H5715_RS06945	COG0826	peptidase U32
H5715_RS06960	COG4771	TonB-dependent receptor
H5715_RS06965	COG0477	Major facilitator Superfamily
H5715_RS06970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5715_RS06975	COG3251	PFAM MbtH domain protein
H5715_RS06980	COG2382	esterase
H5715_RS06985	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS06990	COG3433	isochorismatase activity
H5715_RS06990	COG1535	isochorismatase
H5715_RS06995	COG1021	2,3-dihydroxybenzoate-AMP ligase
H5715_RS07000	COG1169	isochorismate synthase
H5715_RS07030	COG1472	Belongs to the glycosyl hydrolase 3 family
H5715_RS07075	COG2211	Major facilitator Superfamily
H5715_RS07085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H5715_RS07085	COG0678	peroxiredoxin activity
H5715_RS07090	COG4221	oxidoreductase activity
H5715_RS07095	COG3706	GGDEF domain
H5715_RS07100	COG2050	protein possibly involved in aromatic compounds catabolism
H5715_RS07105	COG0318	PFAM AMP-dependent synthetase and ligase
H5715_RS07115	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H5715_RS07125	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H5715_RS07130	COG1169	isochorismate synthase
H5715_RS07225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5715_RS07310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5715_RS07315	COG0778	Nitroreductase
H5715_RS07325	COG0783	Belongs to the Dps family
H5715_RS07330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5715_RS07335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5715_RS07365	COG0667	Aldo Keto reductase
H5715_RS07375	COG3706	GGDEF domain
H5715_RS07390	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H5715_RS07400	COG2226	methyltransferase
H5715_RS07410	COG0716	FMN binding
H5715_RS07415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5715_RS07415	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H5715_RS07430	COG0826	peptidase U32
H5715_RS07445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5715_RS07470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H5715_RS07470	COG0519	Catalyzes the synthesis of GMP from XMP
H5715_RS07480	COG1570	exodeoxyribonuclease VII activity
H5715_RS07490	COG0384	phenazine biosynthesis protein PhzF
H5715_RS07495	COG0730	response to heat
H5715_RS07505	COG1160	GTP binding
H5715_RS07515	COG2976	Protein conserved in bacteria
H5715_RS07520	COG0124	histidyl-tRNA synthetase
H5715_RS07525	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H5715_RS07540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H5715_RS07545	COG0105	UTP biosynthetic process
H5715_RS07555	COG2166	iron-sulfur cluster assembly
H5715_RS07560	COG2151	metal-sulfur cluster biosynthetic enzyme
H5715_RS07565	COG0316	Belongs to the HesB IscA family
H5715_RS07570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H5715_RS07575	COG0719	Fe-S assembly protein
H5715_RS07580	COG0396	ATPase activity
H5715_RS07585	COG0719	Fe-S assembly protein
H5715_RS07610	COG2198	Histidine kinase
H5715_RS07610	COG2205	protein histidine kinase activity
H5715_RS07610	COG0784	Response regulator, receiver
H5715_RS07610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5715_RS07615	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5715_RS07625	COG0343	queuine tRNA-ribosyltransferase activity
H5715_RS07630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H5715_RS07640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5715_RS07650	COG1477	protein flavinylation
H5715_RS07655	COG2871	sodium ion transport
H5715_RS07660	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H5715_RS07675	COG1805	sodium ion transport
H5715_RS07680	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H5715_RS07685	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H5715_RS07695	COG1278	Cold shock
H5715_RS07705	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H5715_RS07710	COG0668	transmembrane transport
H5715_RS07715	COG1472	Belongs to the glycosyl hydrolase 3 family
H5715_RS07735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5715_RS07770	COG0589	response to stress
H5715_RS07775	COG0488	(ABC) transporter
H5715_RS07780	COG0741	lytic transglycosylase activity
H5715_RS07790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H5715_RS07795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H5715_RS07800	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H5715_RS07805	COG1663	tetraacyldisaccharide 4'-kinase activity
H5715_RS07810	COG0848	biopolymer transport protein
H5715_RS07815	COG0811	peptide transport
H5715_RS07820	COG2333	competence protein COMEC
H5715_RS07820	COG0658	competence protein
H5715_RS07835	COG4591	ABC-type transport system involved in lipoprotein release permease component
H5715_RS07840	COG1136	(ABC) transporter
H5715_RS07865	COG0482	sulfurtransferase activity
H5715_RS07870	COG2915	High frequency lysogenization protein hflD homolog
H5715_RS07880	COG2850	peptidyl-arginine hydroxylation
H5715_RS07885	COG2153	protein acetylation
H5715_RS07915	COG0730	response to heat
H5715_RS07925	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H5715_RS07930	COG1862	Preprotein translocase
H5715_RS07940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H5715_RS07945	COG0039	L-malate dehydrogenase activity
H5715_RS07955	COG0084	hydrolase, TatD family'
H5715_RS07970	COG0564	pseudouridine synthase activity
H5715_RS07975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H5715_RS07980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H5715_RS07990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5715_RS07995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5715_RS08010	COG0416	fatty acid biosynthetic process
H5715_RS08015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H5715_RS08025	COG0424	maF-like protein
H5715_RS08030	COG0488	(ABC) transporter
H5715_RS08040	COG0546	phosphoglycolate phosphatase activity
H5715_RS08050	COG1530	ribonuclease E activity
H5715_RS08065	COG4181	ATPase activity
H5715_RS08070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H5715_RS08080	COG0471	metal ion transport
H5715_RS08095	COG0668	transmembrane transport
H5715_RS08125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5715_RS08135	COG1322	Protein conserved in bacteria
H5715_RS08140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5715_RS08155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H5715_RS08160	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H5715_RS08165	COG0740	serine-type endopeptidase activity
H5715_RS08170	COG0544	peptidyl-prolyl cis-trans isomerase activity
H5715_RS08180	COG0183	Belongs to the thiolase family
H5715_RS08185	COG1024	Enoyl-CoA hydratase
H5715_RS08185	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5715_RS08190	COG1396	sequence-specific DNA binding
H5715_RS08190	COG1917	Cupin 2, conserved barrel domain protein
H5715_RS08210	COG0071	Belongs to the small heat shock protein (HSP20) family
H5715_RS08215	COG1090	epimerase
H5715_RS08225	COG1166	arginine decarboxylase activity
H5715_RS08250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5715_RS08285	COG4591	ABC-type transport system involved in lipoprotein release permease component
H5715_RS08295	COG4124	Belongs to the glycosyl hydrolase 26 family
H5715_RS08310	COG0328	RNA-DNA hybrid ribonuclease activity
H5715_RS08325	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS08330	COG3227	Zinc metalloprotease (Elastase)
H5715_RS08345	COG1733	regulation of RNA biosynthetic process
H5715_RS08350	COG1902	pentaerythritol trinitrate reductase activity
H5715_RS08410	COG0776	regulation of translation
H5715_RS08415	COG0072	phenylalanine-tRNA ligase activity
H5715_RS08420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H5715_RS08425	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H5715_RS08430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H5715_RS08435	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H5715_RS08440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H5715_RS08445	COG1088	dTDP-glucose 4,6-dehydratase activity
H5715_RS08510	COG2801	Transposase and inactivated derivatives
H5715_RS08535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5715_RS08555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5715_RS08555	COG0300	oxidoreductase activity
H5715_RS08555	COG3321	synthase
H5715_RS08555	COG4221	oxidoreductase activity
H5715_RS08560	COG4221	oxidoreductase activity
H5715_RS08560	COG3321	synthase
H5715_RS08560	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS08560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5715_RS08565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5715_RS08565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5715_RS08565	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H5715_RS08565	COG3321	synthase
H5715_RS08615	COG3321	synthase
H5715_RS08620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H5715_RS08625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5715_RS08630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5715_RS08635	COG1024	Enoyl-CoA hydratase
H5715_RS08640	COG1024	Enoyl-CoA hydratase
H5715_RS08645	COG3425	synthase
H5715_RS08655	COG3385	transposase activity
H5715_RS08660	COG3321	synthase
H5715_RS08660	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS08660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5715_RS08660	COG4221	oxidoreductase activity
H5715_RS08710	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H5715_RS08730	COG2831	hemolysin activation secretion protein
H5715_RS08760	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H5715_RS08780	COG0438	transferase activity, transferring glycosyl groups
H5715_RS08785	COG0438	transferase activity, transferring glycosyl groups
H5715_RS08795	COG0438	transferase activity, transferring glycosyl groups
H5715_RS08800	COG0438	transferase activity, transferring glycosyl groups
H5715_RS08830	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H5715_RS08850	COG0776	regulation of translation
H5715_RS08860	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H5715_RS08870	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H5715_RS08875	COG0284	orotidine-5'-phosphate decarboxylase activity
H5715_RS08905	COG2895	sulfate adenylyltransferase (ATP) activity
H5715_RS08910	COG0175	sulfate reduction
H5715_RS08915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H5715_RS08920	COG0529	Catalyzes the synthesis of activated sulfate
H5715_RS08935	COG0402	S-adenosylhomocysteine deaminase activity
H5715_RS08940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5715_RS08945	COG0546	phosphoglycolate phosphatase activity
H5715_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS08965	COG0835	chemotaxis
H5715_RS08975	COG1192	Involved in chromosome partitioning
H5715_RS08985	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H5715_RS08990	COG2201	protein-glutamate methylesterase activity
H5715_RS08995	COG2198	Histidine kinase
H5715_RS08995	COG0643	Histidine kinase
H5715_RS08995	COG0784	Response regulator, receiver
H5715_RS09000	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H5715_RS09035	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H5715_RS09045	COG1987	bacterial-type flagellum assembly
H5715_RS09085	COG0745	RESPONSE REGULATOR receiver
H5715_RS09095	COG2201	protein-glutamate methylesterase activity
H5715_RS09100	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H5715_RS09105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H5715_RS09115	COG0835	chemotaxis
H5715_RS09120	COG0643	Histidine kinase
H5715_RS09120	COG2198	Histidine kinase
H5715_RS09125	COG0745	RESPONSE REGULATOR receiver
H5715_RS09170	COG1677	Flagellar hook-basal body complex protein FliE
H5715_RS09190	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H5715_RS09245	COG1256	bacterial-type flagellum assembly
H5715_RS09250	COG1705	Flagellar rod assembly protein muramidase FlgJ
H5715_RS09250	COG3951	Flagellar rod assembly protein muramidase FlgJ
H5715_RS09255	COG1706	bacterial-type flagellum-dependent cell motility
H5715_RS09260	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H5715_RS09270	COG4787	bacterial-type flagellum-dependent cell motility
H5715_RS09280	COG1749	Flagellar hook protein flgE
H5715_RS09285	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H5715_RS09295	COG1815	bacterial-type flagellum-dependent cell motility
H5715_RS09300	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H5715_RS09305	COG0784	Response regulator, receiver
H5715_RS09305	COG0835	chemotaxis
H5715_RS09340	COG0037	tRNA processing
H5715_RS09350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H5715_RS09355	COG2205	protein histidine kinase activity
H5715_RS09355	COG0784	Response regulator, receiver
H5715_RS09375	COG1362	aminopeptidase activity
H5715_RS09380	COG1968	undecaprenyl-diphosphatase activity
H5715_RS09385	COG1214	PFAM Peptidase M22, glycoprotease
H5715_RS09395	COG0563	adenylate kinase activity
H5715_RS09400	COG3956	TIGRFAM MazG family protein
H5715_RS09405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5715_RS09415	COG5002	protein histidine kinase activity
H5715_RS09415	COG2205	protein histidine kinase activity
H5715_RS09415	COG0784	Response regulator, receiver
H5715_RS09420	COG1381	Involved in DNA repair and RecF pathway recombination
H5715_RS09445	COG0481	GTPase activity
H5715_RS09450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5715_RS09485	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H5715_RS09490	COG0354	folic acid binding
H5715_RS09510	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H5715_RS09520	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H5715_RS09540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H5715_RS09560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5715_RS09565	COG0335	large ribosomal subunit rRNA binding
H5715_RS09570	COG0336	Belongs to the RNA methyltransferase TrmD family
H5715_RS09575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H5715_RS09580	COG0228	four-way junction DNA binding
H5715_RS09585	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H5715_RS09595	COG4137	Cytochrome C assembly protein
H5715_RS09600	COG4536	flavin adenine dinucleotide binding
H5715_RS09675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5715_RS09680	COG1595	DNA-templated transcription, initiation
H5715_RS09685	COG1733	regulation of RNA biosynthetic process
H5715_RS09690	COG0604	alcohol dehydrogenase
H5715_RS09740	COG1331	Highly conserved protein containing a thioredoxin domain
H5715_RS09745	COG0686	Belongs to the AlaDH PNT family
H5715_RS09775	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H5715_RS09805	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
H5715_RS09825	COG2914	Belongs to the UPF0125 (RnfH) family
H5715_RS09830	COG4660	Part of a membrane complex involved in electron transport
H5715_RS09845	COG4656	Part of a membrane complex involved in electron transport
H5715_RS09850	COG2878	Part of a membrane complex involved in electron transport
H5715_RS09855	COG4657	Part of a membrane complex involved in electron transport
H5715_RS09870	COG5520	Belongs to the glycosyl hydrolase 30 family
H5715_RS09870	COG3291	Pkd domain containing protein
H5715_RS09870	COG4447	cellulose binding
H5715_RS09910	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H5715_RS09910	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H5715_RS09915	COG0842	Transport permease protein
H5715_RS09920	COG1131	(ABC) transporter
H5715_RS09950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5715_RS09955	COG0436	Aminotransferase
H5715_RS09965	COG5001	Diguanylate cyclase
H5715_RS09965	COG5002	protein histidine kinase activity
H5715_RS09975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5715_RS09980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5715_RS09980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5715_RS09985	COG3101	peptidyl-lysine hydroxylation
H5715_RS10005	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H5715_RS10010	COG3292	Two component regulator propeller
H5715_RS10010	COG2205	protein histidine kinase activity
H5715_RS10010	COG0745	RESPONSE REGULATOR receiver
H5715_RS10015	COG3089	Belongs to the UPF0270 family
H5715_RS10030	COG3409	Peptidoglycan-binding domain 1 protein
H5715_RS10030	COG3267	Type II secretory pathway component ExeA
H5715_RS10065	COG2165	general secretion pathway protein
H5715_RS10075	COG1459	type II secretion system
H5715_RS10080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5715_RS10090	COG3409	Peptidoglycan-binding domain 1 protein
H5715_RS10090	COG3267	Type II secretory pathway component ExeA
H5715_RS10120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H5715_RS10140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5715_RS10140	COG1116	anion transmembrane transporter activity
H5715_RS10150	COG1116	anion transmembrane transporter activity
H5715_RS10160	COG2815	serine threonine protein kinase
H5715_RS10160	COG0515	serine threonine protein kinase
H5715_RS10175	COG2204	response regulator
H5715_RS10185	COG2853	Lipoprotein
H5715_RS10190	COG1643	Atp-dependent helicase
H5715_RS10195	COG0825	malonyl-CoA metabolic process
H5715_RS10200	COG0587	DNA-directed DNA polymerase activity
H5715_RS10250	COG1183	phosphatidylcholine synthase activity
H5715_RS10255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H5715_RS10260	COG0583	DNA-binding transcription factor activity
H5715_RS10280	COG0028	Belongs to the TPP enzyme family
H5715_RS10300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5715_RS10300	COG1042	CoA-binding domain protein
H5715_RS10300	COG0045	succinate-CoA ligase (ADP-forming) activity
H5715_RS10320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5715_RS10320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H5715_RS10370	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H5715_RS10375	COG1047	Peptidyl-prolyl cis-trans
H5715_RS10380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H5715_RS10385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H5715_RS10390	COG0196	riboflavin kinase activity
H5715_RS10395	COG0728	peptidoglycan biosynthetic process
H5715_RS10400	COG2885	chlorophyll binding
H5715_RS10420	COG5520	Belongs to the glycosyl hydrolase 30 family
H5715_RS10420	COG4447	cellulose binding
H5715_RS10420	COG3291	Pkd domain containing protein
H5715_RS10440	COG0425	Belongs to the sulfur carrier protein TusA family
H5715_RS10445	COG4783	chaperone-mediated protein folding
H5715_RS10455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5715_RS10460	COG0023	Translation Initiation Factor
H5715_RS10475	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H5715_RS10480	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5715_RS10485	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5715_RS10490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5715_RS10495	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5715_RS10515	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H5715_RS10520	COG0575	Belongs to the CDS family
H5715_RS10525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H5715_RS10530	COG0233	cytoplasmic translational termination
H5715_RS10535	COG0528	UMP kinase activity
H5715_RS10540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H5715_RS10545	COG0052	Belongs to the universal ribosomal protein uS2 family
H5715_RS10555	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H5715_RS10560	COG0436	Aminotransferase
H5715_RS10565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H5715_RS10570	COG1393	Belongs to the ArsC family
H5715_RS10575	COG2171	N-acyltransferase activity
H5715_RS10580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5715_RS10585	COG0315	cyclic pyranopterin monophosphate synthase activity
H5715_RS10590	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H5715_RS10595	COG0314	molybdopterin synthase activity
H5715_RS10605	COG0742	ribosomal rna small subunit methyltransferase
H5715_RS10610	COG2304	oxidoreductase activity
H5715_RS10690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5715_RS10695	COG0577	efflux transmembrane transporter activity
H5715_RS10695	COG1136	(ABC) transporter
H5715_RS10705	COG3713	MltA-interacting MipA family protein
H5715_RS10750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5715_RS10755	COG1518	maintenance of DNA repeat elements
H5715_RS10790	COG1203	CRISPR-associated helicase, Cas3
H5715_RS10805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5715_RS10810	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H5715_RS10815	COG1765	OsmC-like protein
H5715_RS10825	COG0134	indole-3-glycerol-phosphate synthase activity
H5715_RS10830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H5715_RS10835	COG0512	Glutamine amidotransferase of anthranilate synthase
H5715_RS10845	COG2205	protein histidine kinase activity
H5715_RS10845	COG2198	Histidine kinase
H5715_RS10845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5715_RS10845	COG0784	Response regulator, receiver
H5715_RS10850	COG2204	response regulator
H5715_RS10865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H5715_RS10875	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H5715_RS10880	COG3178	'Phosphotransferase
H5715_RS10885	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H5715_RS10890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5715_RS10895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H5715_RS10900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H5715_RS10905	COG2967	ApaG domain
H5715_RS10910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H5715_RS10920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5715_RS10925	COG2766	serine protein kinase
H5715_RS10930	COG2718	Belongs to the UPF0229 family
H5715_RS10935	COG2719	SpoVR family
H5715_RS10945	COG0617	tRNA 3'-terminal CCA addition
H5715_RS10950	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS10955	COG0071	Belongs to the small heat shock protein (HSP20) family
H5715_RS10970	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H5715_RS10975	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H5715_RS10980	COG1620	l-lactate permease
H5715_RS10985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5715_RS10990	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H5715_RS11005	COG3769	mannosylglycerate metabolic process
H5715_RS11010	COG1215	transferase activity, transferring glycosyl groups
H5715_RS11035	COG1192	Involved in chromosome partitioning
H5715_RS11040	COG2954	triphosphatase activity
H5715_RS11075	COG4969	Belongs to the N-Me-Phe pilin family
H5715_RS11095	COG2181	nitrate reductase activity
H5715_RS11100	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H5715_RS11105	COG1140	nitrate reductase beta subunit
H5715_RS11110	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H5715_RS11115	COG3850	Histidine kinase
H5715_RS11125	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
H5715_RS11130	COG1959	2 iron, 2 sulfur cluster binding
H5715_RS11140	COG0840	transmembrane signaling receptor activity
H5715_RS11145	COG2223	nitrite transmembrane transporter activity
H5715_RS11150	COG2197	response regulator
H5715_RS11165	COG2223	nitrite transmembrane transporter activity
H5715_RS11185	COG4555	ABC transporter
H5715_RS11195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H5715_RS11200	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5715_RS11225	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H5715_RS11235	COG0142	geranyltranstransferase activity
H5715_RS11240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H5715_RS11245	COG0140	phosphoribosyl-ATP diphosphatase activity
H5715_RS11250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5715_RS11255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5715_RS11265	COG2818	Glycosylase
H5715_RS11275	COG2205	protein histidine kinase activity
H5715_RS11280	COG0745	RESPONSE REGULATOR receiver
H5715_RS11295	COG1490	D-aminoacyl-tRNA deacylase activity
H5715_RS11305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H5715_RS11310	COG1984	allophanate hydrolase subunit 2
H5715_RS11320	COG4191	Histidine kinase
H5715_RS11330	COG2755	lipolytic protein G-D-S-L family
H5715_RS11335	COG1472	Belongs to the glycosyl hydrolase 3 family
H5715_RS11365	COG1185	polyribonucleotide nucleotidyltransferase activity
H5715_RS11370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H5715_RS11375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H5715_RS11380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H5715_RS11385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H5715_RS11390	COG0195	Participates in both transcription termination and antitermination
H5715_RS11395	COG0779	Required for maturation of 30S ribosomal subunits
H5715_RS11415	COG0149	triose-phosphate isomerase activity
H5715_RS11420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5715_RS11425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H5715_RS11435	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H5715_RS11445	COG2205	protein histidine kinase activity
H5715_RS11450	COG0745	RESPONSE REGULATOR receiver
H5715_RS11470	COG0505	Belongs to the CarA family
H5715_RS11485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H5715_RS11490	COG0484	heat shock protein binding
H5715_RS11495	COG0443	Heat shock 70 kDa protein
H5715_RS11500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H5715_RS11505	COG0497	DNA recombination
H5715_RS11520	COG2914	Belongs to the UPF0125 (RnfH) family
H5715_RS11525	COG2867	negative regulation of translational initiation
H5715_RS11530	COG0733	neurotransmitter:sodium symporter activity
H5715_RS11535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H5715_RS11570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5715_RS11570	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5715_RS11575	COG0367	asparagine synthase
H5715_RS11640	COG2963	transposase activity
H5715_RS11665	COG2985	domain, Protein
H5715_RS11680	COG0643	Histidine kinase
H5715_RS11680	COG2198	Histidine kinase
H5715_RS11690	COG5002	protein histidine kinase activity
H5715_RS11690	COG0784	Response regulator, receiver
H5715_RS11690	COG2198	Histidine kinase
H5715_RS11755	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5715_RS11760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5715_RS11785	COG3784	Protein of unknown function (DUF1318)
H5715_RS11790	COG0659	secondary active sulfate transmembrane transporter activity
H5715_RS11810	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H5715_RS11835	COG0583	DNA-binding transcription factor activity
H5715_RS11860	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS11890	COG0840	transmembrane signaling receptor activity
H5715_RS11900	COG1785	Belongs to the alkaline phosphatase family
H5715_RS11905	COG1785	Belongs to the alkaline phosphatase family
H5715_RS11920	COG3693	PFAM glycoside hydrolase, family 10
H5715_RS11925	COG3775	system Galactitol-specific IIC component
H5715_RS11955	COG1595	DNA-templated transcription, initiation
H5715_RS11985	COG1283	sodium-dependent phosphate transmembrane transporter activity
H5715_RS12050	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS12055	COG0840	transmembrane signaling receptor activity
H5715_RS12060	COG0493	'glutamate synthase
H5715_RS12065	COG0067	glutamate synthase
H5715_RS12065	COG0069	glutamate synthase activity
H5715_RS12065	COG0070	glutamate synthase
H5715_RS12070	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H5715_RS12090	COG0705	Rhomboid family
H5715_RS12105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H5715_RS12135	COG0133	tryptophan synthase activity
H5715_RS12190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H5715_RS12215	COG4191	Histidine kinase
H5715_RS12230	COG0123	including yeast histone deacetylase and acetoin utilization protein
H5715_RS12240	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS12250	COG0798	PFAM Bile acid sodium symporter
H5715_RS12275	COG4771	TonB-dependent receptor
H5715_RS12285	COG2205	protein histidine kinase activity
H5715_RS12295	COG3634	alkyl hydroperoxide reductase activity
H5715_RS12350	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H5715_RS12355	COG1643	Atp-dependent helicase
H5715_RS12360	COG3148	PFAM DTW domain containing protein
H5715_RS12370	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H5715_RS12390	COG4773	Receptor
H5715_RS12400	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS12540	COG0753	catalase activity
H5715_RS12550	COG0513	Belongs to the DEAD box helicase family
H5715_RS12580	COG4628	conserved protein (DUF2132)
H5715_RS12600	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS12605	COG1013	pyruvate-flavodoxin oxidoreductase activity
H5715_RS12605	COG0674	pyruvate-flavodoxin oxidoreductase activity
H5715_RS12605	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H5715_RS12605	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H5715_RS12610	COG0493	'glutamate synthase
H5715_RS12615	COG1720	tRNA m6t6A37 methyltransferase activity
H5715_RS12650	COG0306	phosphate transporter
H5715_RS12655	COG1392	Phosphate transport regulator
H5715_RS12670	COG3530	Putative quorum-sensing-regulated virulence factor
H5715_RS12685	COG1607	acyl-coa hydrolase
H5715_RS12690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H5715_RS12695	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H5715_RS12710	COG0527	aspartate kinase activity
H5715_RS12720	COG2205	protein histidine kinase activity
H5715_RS12720	COG2202	Pas domain
H5715_RS12725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H5715_RS12730	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H5715_RS12740	COG0330	HflC and HflK could
H5715_RS12745	COG0330	HflC and HflK could
H5715_RS12750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5715_RS12755	COG1923	regulation of RNA biosynthetic process
H5715_RS12760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H5715_RS12765	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H5715_RS12770	COG0860	N-Acetylmuramoyl-L-alanine amidase
H5715_RS12775	COG0802	atpase or kinase
H5715_RS12780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H5715_RS12780	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H5715_RS12785	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H5715_RS12805	COG1162	GTPase activity
H5715_RS12810	COG0688	phosphatidylethanolamine metabolic process
H5715_RS12820	COG0784	Response regulator, receiver
H5715_RS12820	COG3437	response regulator, receiver
H5715_RS12825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H5715_RS12835	COG0493	'glutamate synthase
H5715_RS12840	COG0069	glutamate synthase activity
H5715_RS12840	COG0067	glutamate synthase
H5715_RS12840	COG0070	glutamate synthase
H5715_RS12850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H5715_RS12890	COG0254	rRNA binding
H5715_RS12895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H5715_RS12910	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H5715_RS12915	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H5715_RS12925	COG2226	methyltransferase
H5715_RS12935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5715_RS12955	COG0792	nuclease activity
H5715_RS12960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H5715_RS12965	COG2823	Periplasmic or secreted lipoprotein
H5715_RS12970	COG0183	Belongs to the thiolase family
H5715_RS12975	COG1704	LemA family
H5715_RS12980	COG0501	Belongs to the peptidase M48B family
H5715_RS12995	COG2969	positive regulation of protein catabolic process
H5715_RS13000	COG0625	glutathione transferase activity
H5715_RS13005	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H5715_RS13010	COG0723	plastoquinol--plastocyanin reductase activity
H5715_RS13015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H5715_RS13020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H5715_RS13025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H5715_RS13035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5715_RS13045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5715_RS13050	COG1053	succinate dehydrogenase
H5715_RS13090	COG1272	protein, Hemolysin III
H5715_RS13100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H5715_RS13105	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H5715_RS13110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H5715_RS13115	COG5007	Belongs to the BolA IbaG family
H5715_RS13135	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H5715_RS13150	COG1137	ATPase activity
H5715_RS13165	COG1660	Displays ATPase and GTPase activities
H5715_RS13175	COG2239	Acts as a magnesium transporter
H5715_RS13180	COG3028	Belongs to the UPF0307 family
H5715_RS13185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5715_RS13190	COG3509	depolymerase
H5715_RS13205	COG0424	maF-like protein
H5715_RS13215	COG1792	Involved in formation and maintenance of cell shape
H5715_RS13220	COG1077	Cell shape determining protein MreB Mrl
H5715_RS13225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5715_RS13230	COG0154	amidase activity
H5715_RS13235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5715_RS13245	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
H5715_RS13255	COG0513	Belongs to the DEAD box helicase family
H5715_RS13270	COG4774	siderophore transport
H5715_RS13280	COG2890	protein-(glutamine-N5) methyltransferase activity
H5715_RS13285	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H5715_RS13290	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H5715_RS13300	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H5715_RS13305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H5715_RS13315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5715_RS13320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H5715_RS13325	COG0193	aminoacyl-tRNA hydrolase activity
H5715_RS13380	COG2201	protein-glutamate methylesterase activity
H5715_RS13385	COG2204	response regulator
H5715_RS13400	COG0463	Glycosyl transferase, family 2
H5715_RS13410	COG2204	response regulator
H5715_RS13425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5715_RS13455	COG1216	Glycosyl transferase, family 2
H5715_RS13470	COG5520	Belongs to the glycosyl hydrolase 30 family
H5715_RS13470	COG4447	cellulose binding
H5715_RS13470	COG3291	Pkd domain containing protein
H5715_RS13505	COG2207	Transcriptional regulator
H5715_RS13505	COG1917	Cupin 2, conserved barrel domain protein
H5715_RS13530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5715_RS13555	COG4124	Belongs to the glycosyl hydrolase 26 family
H5715_RS13575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5715_RS13595	COG4221	oxidoreductase activity
H5715_RS13600	COG2207	Transcriptional regulator
H5715_RS13605	COG0596	Alpha beta hydrolase
H5715_RS13615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5715_RS13620	COG1702	phosphate starvation-inducible protein PhoH
H5715_RS13625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H5715_RS13635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H5715_RS13640	COG2010	Cytochrome c
H5715_RS13665	COG0495	leucyl-tRNA aminoacylation
H5715_RS13675	COG1466	dna polymerase III delta subunit
H5715_RS13720	COG1132	(ABC) transporter
H5715_RS13725	COG0432	Pfam Uncharacterised protein family UPF0047
H5715_RS13745	COG5265	(ABC) transporter
H5715_RS13800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5715_RS13810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H5715_RS13820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5715_RS13825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H5715_RS13840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5715_RS13840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5715_RS13845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H5715_RS13850	COG0189	ligase activity
H5715_RS13870	COG0189	ligase activity
H5715_RS13885	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H5715_RS13885	COG3264	Mechanosensitive ion channel
H5715_RS13890	COG0598	Magnesium transport protein CorA
H5715_RS13900	COG2239	Acts as a magnesium transporter
H5715_RS13910	COG0668	transmembrane transport
H5715_RS13920	COG4067	protein conserved in archaea
H5715_RS13920	COG0189	ligase activity
H5715_RS13925	COG1162	GTPase activity
H5715_RS13940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5715_RS13950	COG0488	(ABC) transporter
H5715_RS13965	COG4452	Inner membrane protein CreD
H5715_RS13975	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H5715_RS13980	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H5715_RS13985	COG3012	SEC-C Motif Domain Protein
H5715_RS13995	COG2304	oxidoreductase activity
H5715_RS14030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5715_RS14040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5715_RS14050	COG3706	GGDEF domain
H5715_RS14055	COG0840	transmembrane signaling receptor activity
H5715_RS14060	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H5715_RS14070	COG1132	(ABC) transporter
H5715_RS14075	COG1519	Transferase
H5715_RS14130	COG0659	secondary active sulfate transmembrane transporter activity
H5715_RS14135	COG0589	response to stress
H5715_RS14140	COG1671	Belongs to the UPF0178 family
H5715_RS14150	COG3345	alpha-galactosidase
H5715_RS14175	COG3150	esterase
H5715_RS14190	COG0494	nUDIX hydrolase
H5715_RS14195	COG1538	Outer membrane efflux protein
H5715_RS14200	COG2183	response to ionizing radiation
H5715_RS14215	COG1846	Transcriptional regulator
H5715_RS14250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5715_RS14270	COG0534	Mate efflux family protein
H5715_RS14300	COG0811	peptide transport
H5715_RS14330	COG1414	Transcriptional regulator
H5715_RS14360	COG3156	type II secretion system protein K
H5715_RS14400	COG3031	protein transport across the cell outer membrane
H5715_RS14410	COG2918	glutathione biosynthetic process
H5715_RS14430	COG0545	Peptidyl-prolyl cis-trans isomerase
H5715_RS14445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H5715_RS14450	COG2363	Small membrane protein
H5715_RS14460	COG2177	Part of the ABC transporter FtsEX involved in
H5715_RS14465	COG2884	Cell division ATP-binding protein ftsE
H5715_RS14470	COG0552	protein localization to endoplasmic reticulum
H5715_RS14475	COG0742	ribosomal rna small subunit methyltransferase
H5715_RS14480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H5715_RS14485	COG3072	Adenylate cyclase
H5715_RS14500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H5715_RS14515	COG0347	Belongs to the P(II) protein family
H5715_RS14520	COG0004	ammonium transporteR
H5715_RS14525	COG0347	Belongs to the P(II) protein family
H5715_RS14535	COG0281	malic enzyme
H5715_RS14545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5715_RS14550	COG2205	protein histidine kinase activity
H5715_RS14550	COG0784	Response regulator, receiver
H5715_RS14550	COG5002	protein histidine kinase activity
H5715_RS14570	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H5715_RS14595	COG3647	Membrane
H5715_RS14605	COG3250	beta-galactosidase activity
H5715_RS14610	COG1942	4-Oxalocrotonate Tautomerase
H5715_RS14615	COG0513	Belongs to the DEAD box helicase family
H5715_RS14625	COG2814	Major facilitator Superfamily
H5715_RS14725	COG3081	Nucleoid-associated protein
H5715_RS14830	COG4115	mRNA cleavage
H5715_RS14885	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS14895	COG2959	enzyme of heme biosynthesis
H5715_RS14905	COG0181	hydroxymethylbilane synthase activity
H5715_RS14915	COG3275	phosphorelay sensor kinase activity
H5715_RS14920	COG0165	Argininosuccinate lyase
H5715_RS14925	COG0708	Exodeoxyribonuclease III
H5715_RS14930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H5715_RS14940	COG1309	transcriptional regulator
H5715_RS14945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H5715_RS14960	COG2003	Belongs to the UPF0758 family
H5715_RS14970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H5715_RS14975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H5715_RS14980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H5715_RS14990	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H5715_RS14995	COG1561	YicC-like family, N-terminal region
H5715_RS15000	COG0194	GDP metabolic process
H5715_RS15005	COG1758	RNA polymerase activity
H5715_RS15010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5715_RS15020	COG2045	Belongs to the ComB family
H5715_RS15025	COG0583	DNA-binding transcription factor activity
H5715_RS15045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H5715_RS15050	COG0583	DNA-binding transcription factor activity
H5715_RS15055	COG3738	Protein conserved in bacteria
H5715_RS15095	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H5715_RS15105	COG1301	dicarboxylic acid transport
H5715_RS15145	COG3022	response to hydroperoxide
H5715_RS15180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5715_RS15190	COG0573	inorganic phosphate transmembrane transporter activity
H5715_RS15205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H5715_RS15220	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H5715_RS15225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H5715_RS15245	COG2192	nodulation
H5715_RS15250	COG3132	Protein of unknown function, DUF480
H5715_RS15255	COG0210	DNA helicase
H5715_RS15270	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H5715_RS15280	COG2017	converts alpha-aldose to the beta-anomer
H5715_RS15295	COG0477	Major facilitator Superfamily
H5715_RS15305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5715_RS15315	COG0577	efflux transmembrane transporter activity
H5715_RS15315	COG1136	(ABC) transporter
H5715_RS15320	COG1136	(ABC) transporter
H5715_RS15325	COG3507	Belongs to the glycosyl hydrolase 43 family
H5715_RS15355	COG4948	Mandelate Racemase Muconate Lactonizing
H5715_RS15360	COG1904	glucuronate isomerase
H5715_RS15405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5715_RS15415	COG2198	Histidine kinase
H5715_RS15415	COG2205	protein histidine kinase activity
H5715_RS15415	COG0784	Response regulator, receiver
H5715_RS15430	COG3706	GGDEF domain
H5715_RS15445	COG2193	ferroxidase activity
H5715_RS15450	COG0510	thiamine kinase activity
H5715_RS15465	COG4206	TonB-dependent receptor
H5715_RS15470	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS15515	COG4771	TonB-dependent receptor
H5715_RS15520	COG0735	belongs to the Fur family
H5715_RS15525	COG1280	lysine exporter protein (LysE YggA)
H5715_RS15535	COG3706	GGDEF domain
H5715_RS15540	COG2205	protein histidine kinase activity
H5715_RS15545	COG0745	RESPONSE REGULATOR receiver
H5715_RS15565	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5715_RS15570	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H5715_RS15575	COG4988	ABC transporter
H5715_RS15580	COG4890	Cyd operon protein YbgT
H5715_RS15585	COG1294	oxidase, subunit
H5715_RS15680	COG1335	isochorismatase
H5715_RS15705	COG1309	transcriptional regulator
H5715_RS15735	COG0489	protein tyrosine kinase activity
H5715_RS15765	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H5715_RS15870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H5715_RS15875	COG1349	DNA-binding transcription factor activity
H5715_RS15885	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5715_RS15905	COG2255	four-way junction helicase activity
H5715_RS15940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H5715_RS15965	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H5715_RS15970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H5715_RS15975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H5715_RS15980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H5715_RS15985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H5715_RS15990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H5715_RS16000	COG0356	it plays a direct role in the translocation of protons across the membrane
H5715_RS16020	COG1475	DNA binding
H5715_RS16025	COG1192	Involved in chromosome partitioning
H5715_RS16030	COG0357	Ribosomal RNA small subunit methyltransferase G
H5715_RS16035	COG3279	Response regulator of the LytR AlgR family
H5715_RS16040	COG3275	phosphorelay sensor kinase activity
H5715_RS16060	COG0445	tRNA wobble uridine modification
H5715_RS16065	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H5715_RS16070	COG0706	membrane insertase activity
H5715_RS16075	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H5715_RS16080	COG0594	ribonuclease P activity
H5715_RS16085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H5715_RS16090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H5715_RS16100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5715_RS16135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5715_RS16145	COG2095	MarC family integral membrane protein
H5715_RS16165	COG0751	glycine-tRNA ligase activity
H5715_RS16170	COG0752	glycyl-tRNA synthetase alpha subunit
H5715_RS16175	COG1560	Kdo2-lipid A biosynthetic process
H5715_RS16185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5715_RS16190	COG0569	domain protein
H5715_RS16200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5715_RS16205	COG0242	peptide deformylase activity
H5715_RS16215	COG0758	DNA mediated transformation
H5715_RS16225	COG0009	L-threonylcarbamoyladenylate synthase
H5715_RS16230	COG0408	coproporphyrinogen oxidase activity
H5715_RS16235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H5715_RS16255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5715_RS16260	COG1121	(ABC) transporter
H5715_RS16265	COG0735	belongs to the Fur family
H5715_RS16270	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H5715_RS16330	COG1278	Cold shock
H5715_RS16355	COG0534	Mate efflux family protein
H5715_RS16360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5715_RS16365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5715_RS16370	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H5715_RS16375	COG1845	cytochrome c oxidase, subunit III
H5715_RS16385	COG3346	SURF1 family
H5715_RS16395	COG1612	heme a metabolic process
H5715_RS16400	COG0109	protoheme IX farnesyltransferase activity
H5715_RS16440	COG4536	flavin adenine dinucleotide binding
H5715_RS16460	COG1074	ATP-dependent DNA helicase activity
H5715_RS16535	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H5715_RS16540	COG1312	Catalyzes the dehydration of D-mannonate
H5715_RS16545	COG2706	6-phosphogluconolactonase activity
H5715_RS16550	COG0667	Aldo Keto reductase
H5715_RS16555	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H5715_RS16580	COG5002	protein histidine kinase activity
H5715_RS16580	COG0784	Response regulator, receiver
H5715_RS16580	COG2205	protein histidine kinase activity
H5715_RS16590	COG1136	(ABC) transporter
H5715_RS16595	COG0577	efflux transmembrane transporter activity
H5715_RS16600	COG1136	(ABC) transporter
H5715_RS16600	COG0577	efflux transmembrane transporter activity
H5715_RS16625	COG0393	Putative heavy-metal-binding
H5715_RS16650	COG2081	HI0933 family
H5715_RS16655	COG2314	TM2 domain
H5715_RS16680	COG2962	Rard protein
H5715_RS16685	COG2827	Endonuclease containing a URI domain
H5715_RS16690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H5715_RS16695	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5715_RS16700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5715_RS16710	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H5715_RS16720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5715_RS16760	COG0438	transferase activity, transferring glycosyl groups
H5715_RS16765	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H5715_RS16785	COG2244	polysaccharide biosynthetic process
H5715_RS16795	COG0367	asparagine synthase
H5715_RS16805	COG0438	transferase activity, transferring glycosyl groups
H5715_RS16810	COG0438	transferase activity, transferring glycosyl groups
H5715_RS16855	COG3425	synthase
H5715_RS16860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5715_RS16870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H5715_RS16930	COG0210	DNA helicase
H5715_RS16945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5715_RS16945	COG4221	oxidoreductase activity
H5715_RS16945	COG3321	synthase
H5715_RS16945	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS16945	COG3321	synthase
H5715_RS16945	COG4221	oxidoreductase activity
H5715_RS16945	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS16945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5715_RS16960	COG0606	chelatase, subunit chli
H5715_RS16970	COG0829	nickel cation binding
H5715_RS16975	COG0831	urea catabolic process
H5715_RS16980	COG0832	Belongs to the urease beta subunit family
H5715_RS16985	COG0804	urea catabolic process
H5715_RS16990	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H5715_RS16995	COG0830	nickel cation binding
H5715_RS17020	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5715_RS17025	COG0411	ABC transporter
H5715_RS17035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H5715_RS17045	COG2813	Specifically methylates the guanine in position
H5715_RS17045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5715_RS17050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5715_RS17085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H5715_RS17090	COG1678	Uncharacterized ACR, COG1678
H5715_RS17100	COG0189	ligase activity
H5715_RS17130	COG0643	Histidine kinase
H5715_RS17130	COG0784	Response regulator, receiver
H5715_RS17130	COG2198	Histidine kinase
H5715_RS17135	COG2201	protein-glutamate methylesterase activity
H5715_RS17145	COG1609	Transcriptional regulator
H5715_RS17165	COG1640	4-alpha-glucanotransferase
H5715_RS17170	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H5715_RS17175	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H5715_RS17180	COG1011	Hydrolase
H5715_RS17185	COG0494	nUDIX hydrolase
H5715_RS17190	COG1218	3'(2'),5'-bisphosphate nucleotidase
H5715_RS17210	COG3128	pkhd-type hydroxylase
H5715_RS17220	COG4774	siderophore transport
H5715_RS17230	COG0848	biopolymer transport protein
H5715_RS17235	COG0848	biopolymer transport protein
H5715_RS17240	COG0811	peptide transport
H5715_RS17265	COG2873	o-acetylhomoserine
H5715_RS17280	COG0513	Belongs to the DEAD box helicase family
H5715_RS17295	COG2116	formate transmembrane transporter activity
H5715_RS17300	COG0515	serine threonine protein kinase
H5715_RS17300	COG2815	serine threonine protein kinase
H5715_RS17305	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H5715_RS17340	COG1404	Belongs to the peptidase S8 family
H5715_RS17355	COG2977	Belongs to the P-Pant transferase superfamily
H5715_RS17400	COG2801	Transposase and inactivated derivatives
H5715_RS17450	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H5715_RS17455	COG1194	a g-specific adenine glycosylase
H5715_RS17480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5715_RS17485	COG0509	glycine decarboxylation via glycine cleavage system
H5715_RS17525	COG1051	belongs to the nudix hydrolase family
H5715_RS17530	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
H5715_RS17535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H5715_RS17540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H5715_RS17555	COG0811	peptide transport
H5715_RS17560	COG0811	peptide transport
H5715_RS17565	COG0848	biopolymer transport protein
H5715_RS17585	COG0129	dihydroxy-acid dehydratase activity
H5715_RS17590	COG0745	RESPONSE REGULATOR receiver
H5715_RS17595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H5715_RS17595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H5715_RS17615	COG1882	Formate acetyltransferase
H5715_RS17625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H5715_RS17635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H5715_RS17645	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H5715_RS17650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H5715_RS17655	COG0640	Transcriptional regulator
H5715_RS17660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H5715_RS17665	COG0126	phosphoglycerate kinase activity
H5715_RS17690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5715_RS17695	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H5715_RS17700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5715_RS17720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H5715_RS17740	COG3079	Belongs to the UPF0149 family
H5715_RS17745	COG0006	proline dipeptidase activity
H5715_RS17750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5715_RS17755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5715_RS17760	COG2995	paraquat-inducible protein a
H5715_RS17765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5715_RS17765	COG3008	intermembrane lipid transfer
H5715_RS17785	COG1846	Transcriptional regulator
H5715_RS17800	COG1917	Cupin 2, conserved barrel domain protein
H5715_RS17805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5715_RS17825	COG0438	transferase activity, transferring glycosyl groups
H5715_RS17835	COG0131	Imidazoleglycerol-phosphate dehydratase
H5715_RS17840	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H5715_RS17845	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H5715_RS17850	COG0107	imidazoleglycerol-phosphate synthase activity
H5715_RS17860	COG0745	RESPONSE REGULATOR receiver
H5715_RS17875	COG2861	carbohydrate metabolic process
H5715_RS17880	COG0793	Belongs to the peptidase S41A family
H5715_RS17885	COG4942	peptidase
H5715_RS17890	COG0588	phosphoglycerate mutase activity
H5715_RS17895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5715_RS17900	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H5715_RS17915	COG3852	Histidine kinase
H5715_RS17920	COG3300	MHYT domain
H5715_RS17920	COG5001	Diguanylate cyclase
H5715_RS17925	COG2205	protein histidine kinase activity
H5715_RS17925	COG0745	RESPONSE REGULATOR receiver
H5715_RS17925	COG3292	Two component regulator propeller
H5715_RS17930	COG0174	glutamine synthetase
H5715_RS17935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5715_RS17935	COG0301	tRNA thio-modification
H5715_RS17955	COG1609	Transcriptional regulator
H5715_RS17960	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
H5715_RS17965	COG2942	2-epimerase
H5715_RS17975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5715_RS17980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5715_RS18000	COG2022	thiamine diphosphate biosynthetic process
H5715_RS18005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H5715_RS18025	COG1217	gtp-binding protein TYPA
H5715_RS18045	COG0346	lactoylglutathione lyase activity
H5715_RS18055	COG0514	ATP-dependent DNA helicase (RecQ)
H5715_RS18060	COG4989	oxidoreductase activity
H5715_RS18080	COG1047	Peptidyl-prolyl cis-trans
H5715_RS18085	COG4628	conserved protein (DUF2132)
H5715_RS18090	COG2501	S4 domain
H5715_RS18095	COG2207	Transcriptional regulator
H5715_RS18100	COG0534	Mate efflux family protein
H5715_RS18110	COG0726	polysaccharide deacetylase
H5715_RS18120	COG1785	Belongs to the alkaline phosphatase family
H5715_RS18135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H5715_RS18140	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H5715_RS18145	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H5715_RS18150	COG1428	Deoxynucleoside kinase
H5715_RS18155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H5715_RS18170	COG3852	Histidine kinase
H5715_RS18180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5715_RS18185	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H5715_RS18190	COG1489	DNA binding
H5715_RS18205	COG1876	peptidase activity
H5715_RS18210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5715_RS18225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H5715_RS18240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5715_RS18280	COG0546	phosphoglycolate phosphatase activity
H5715_RS18300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H5715_RS18305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H5715_RS18315	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H5715_RS18320	COG0768	penicillin binding
H5715_RS18325	COG0772	Belongs to the SEDS family
H5715_RS18330	COG2951	lytic endotransglycosylase activity
H5715_RS18345	COG3291	Pkd domain containing protein
H5715_RS18350	COG1686	Belongs to the peptidase S11 family
H5715_RS18355	COG2921	Belongs to the UPF0250 family
H5715_RS18360	COG0321	lipoyl(octanoyl) transferase activity
H5715_RS18365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H5715_RS18375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5715_RS18470	COG0309	Hydrogenase expression formation protein (HypE)
H5715_RS18475	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H5715_RS18495	COG0298	carbon dioxide binding
H5715_RS18505	COG2871	sodium ion transport
H5715_RS18535	COG0205	6-phosphofructokinase activity
H5715_RS18540	COG0784	Response regulator, receiver
H5715_RS18540	COG2205	protein histidine kinase activity
H5715_RS18540	COG5002	protein histidine kinase activity
H5715_RS18545	COG0243	molybdopterin cofactor binding
H5715_RS18560	COG0823	Involved in the tonB-independent uptake of proteins
H5715_RS18590	COG4206	TonB-dependent receptor
H5715_RS18615	COG0084	hydrolase, TatD family'
H5715_RS18625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H5715_RS18630	COG0069	glutamate synthase activity
H5715_RS18650	COG3706	GGDEF domain
H5715_RS18660	COG4953	penicillin-binding protein 1C
H5715_RS18665	COG2373	Large extracellular alpha-helical protein
H5715_RS18680	COG0655	NAD(P)H dehydrogenase (quinone) activity
H5715_RS18705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H5715_RS18720	COG2972	Histidine kinase
H5715_RS18725	COG3279	Response regulator of the LytR AlgR family
H5715_RS18735	COG2197	response regulator
H5715_RS18740	COG4585	Histidine kinase
H5715_RS18760	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H5715_RS18765	COG3250	beta-galactosidase activity
H5715_RS18790	COG4771	TonB-dependent receptor
H5715_RS18800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H5715_RS18810	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H5715_RS18830	COG2755	lipolytic protein G-D-S-L family
H5715_RS18835	COG1132	(ABC) transporter
H5715_RS18840	COG2226	methyltransferase
H5715_RS18875	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H5715_RS18880	COG4771	TonB-dependent receptor
H5715_RS18890	COG1846	Transcriptional regulator
H5715_RS18895	COG0386	Belongs to the glutathione peroxidase family
H5715_RS18915	COG3228	Belongs to the MtfA family
H5715_RS18925	COG0358	DNA primase activity
H5715_RS18930	COG0784	Response regulator, receiver
H5715_RS18930	COG2205	protein histidine kinase activity
H5715_RS18935	COG5001	Diguanylate cyclase
H5715_RS18935	COG5002	protein histidine kinase activity
H5715_RS18940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5715_RS18955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H5715_RS18965	COG0745	RESPONSE REGULATOR receiver
H5715_RS18985	COG2315	Protein conserved in bacteria
H5715_RS18990	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H5715_RS18995	COG3706	GGDEF domain
H5715_RS19005	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H5715_RS19010	COG0156	8-amino-7-oxononanoate synthase activity
H5715_RS19015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5715_RS19015	COG2226	methyltransferase
H5715_RS19015	COG0596	Alpha beta hydrolase
H5715_RS19020	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H5715_RS19035	COG1960	acyl-CoA dehydrogenase activity
H5715_RS19075	COG2974	May be involved in recombination
H5715_RS19080	COG0545	Peptidyl-prolyl cis-trans isomerase
H5715_RS19110	COG2391	methyltransferase activity
H5715_RS19115	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
H5715_RS19140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5715_RS19155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H5715_RS19155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5715_RS19170	COG0583	DNA-binding transcription factor activity
H5715_RS19175	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H5715_RS19195	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS19200	COG0583	DNA-binding transcription factor activity
H5715_RS19230	COG3693	PFAM glycoside hydrolase, family 10
H5715_RS19245	COG1476	TRANSCRIPTIONal
H5715_RS19255	COG4974	Belongs to the 'phage' integrase family
H5715_RS19275	COG2856	Zn peptidase
H5715_RS19325	COG4584	PFAM Integrase catalytic
H5715_RS19330	COG1484	DNA-dependent DNA replication
H5715_RS19340	COG4974	Belongs to the 'phage' integrase family
H5715_RS19390	COG0439	Biotin carboxylase
H5715_RS19405	COG3842	ATPase activity
H5715_RS19410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5715_RS19445	COG0330	HflC and HflK could
H5715_RS19495	COG0557	exoribonuclease II activity
H5715_RS19500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5715_RS19505	COG0360	Binds together with S18 to 16S ribosomal RNA
H5715_RS19510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H5715_RS19520	COG0359	binds to the 23S rRNA
H5715_RS19525	COG0305	Participates in initiation and elongation during chromosome replication
H5715_RS19530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H5715_RS19535	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H5715_RS19540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5715_RS19545	COG1047	Peptidyl-prolyl cis-trans
H5715_RS19550	COG1611	Belongs to the LOG family
H5715_RS19555	COG2840	Smr protein MutS2
H5715_RS19575	COG3830	Belongs to the UPF0237 family
H5715_RS19575	COG0560	Phosphoserine phosphatase
H5715_RS19590	COG1509	lysine 2,3-aminomutase activity
H5715_RS19600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H5715_RS19630	COG1802	Transcriptional regulator
H5715_RS19640	COG0346	lactoylglutathione lyase activity
H5715_RS19650	COG3693	PFAM glycoside hydrolase, family 10
H5715_RS19685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H5715_RS19690	COG0739	heme binding
H5715_RS19700	COG3706	GGDEF domain
H5715_RS19735	COG1429	ligase activity, forming nitrogen-metal bonds
H5715_RS19765	COG4968	Prepilin-type N-terminal cleavage methylation domain
H5715_RS19800	COG1028	Short-chain dehydrogenase reductase Sdr
H5715_RS19805	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H5715_RS19815	COG4677	pectinesterase activity
H5715_RS19830	COG1595	DNA-templated transcription, initiation
H5715_RS19835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H5715_RS19850	COG0438	transferase activity, transferring glycosyl groups
H5715_RS19855	COG1216	Glycosyl transferase, family 2
H5715_RS19865	COG1560	Kdo2-lipid A biosynthetic process
H5715_RS19870	COG0297	glycogen (starch) synthase activity
H5715_RS19875	COG1216	Glycosyl transferase, family 2