locus-tag	class	description
H5647_RS00045	COG1560	Kdo2-lipid A biosynthetic process
H5647_RS00050	COG0438	transferase activity, transferring glycosyl groups
H5647_RS00060	COG0463	Glycosyl transferase, family 2
H5647_RS00080	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H5647_RS00145	COG4771	TonB-dependent receptor
H5647_RS00165	COG2977	Belongs to the P-Pant transferase superfamily
H5647_RS00175	COG1028	Short-chain dehydrogenase reductase Sdr
H5647_RS00180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5647_RS00185	COG1535	isochorismatase
H5647_RS00185	COG3433	isochorismatase activity
H5647_RS00190	COG1021	2,3-dihydroxybenzoate-AMP ligase
H5647_RS00195	COG1169	isochorismate synthase
H5647_RS00220	COG3128	pkhd-type hydroxylase
H5647_RS00230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H5647_RS00235	COG0739	heme binding
H5647_RS00240	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H5647_RS00260	COG3693	PFAM glycoside hydrolase, family 10
H5647_RS00275	COG1032	radical SAM domain protein
H5647_RS00280	COG1802	Transcriptional regulator
H5647_RS00305	COG2192	nodulation
H5647_RS00320	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H5647_RS00325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H5647_RS00350	COG1509	lysine 2,3-aminomutase activity
H5647_RS00370	COG3830	Belongs to the UPF0237 family
H5647_RS00370	COG0560	Phosphoserine phosphatase
H5647_RS00400	COG1611	Belongs to the LOG family
H5647_RS00405	COG1047	Peptidyl-prolyl cis-trans
H5647_RS00410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5647_RS00415	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H5647_RS00420	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H5647_RS00425	COG0305	Participates in initiation and elongation during chromosome replication
H5647_RS00430	COG0359	binds to the 23S rRNA
H5647_RS00440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H5647_RS00450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5647_RS00455	COG0557	exoribonuclease II activity
H5647_RS00465	COG0582	viral genome integration into host DNA
H5647_RS00475	COG1959	2 iron, 2 sulfur cluster binding
H5647_RS00485	COG3177	Filamentation induced by cAMP protein fic
H5647_RS00515	COG0545	Peptidyl-prolyl cis-trans isomerase
H5647_RS00520	COG2974	May be involved in recombination
H5647_RS00555	COG1960	acyl-CoA dehydrogenase activity
H5647_RS00575	COG3693	PFAM glycoside hydrolase, family 10
H5647_RS00600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H5647_RS00605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5647_RS00605	COG2226	methyltransferase
H5647_RS00605	COG0596	Alpha beta hydrolase
H5647_RS00610	COG0156	8-amino-7-oxononanoate synthase activity
H5647_RS00615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H5647_RS00620	COG1040	competence protein
H5647_RS00625	COG3706	GGDEF domain
H5647_RS00635	COG2315	Protein conserved in bacteria
H5647_RS00640	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H5647_RS00655	COG0625	glutathione transferase activity
H5647_RS00660	COG0840	transmembrane signaling receptor activity
H5647_RS00665	COG0358	DNA primase activity
H5647_RS00670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H5647_RS00680	COG1121	(ABC) transporter
H5647_RS00690	COG1472	Belongs to the glycosyl hydrolase 3 family
H5647_RS00710	COG1690	Belongs to the RtcB family
H5647_RS00715	COG0668	transmembrane transport
H5647_RS00790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5647_RS00835	COG1132	(ABC) transporter
H5647_RS00850	COG1595	DNA-templated transcription, initiation
H5647_RS00855	COG4774	siderophore transport
H5647_RS00865	COG1307	EDD domain protein, DegV family
H5647_RS00905	COG3250	beta-galactosidase activity
H5647_RS00910	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H5647_RS00915	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H5647_RS00925	COG4585	Histidine kinase
H5647_RS00930	COG2197	response regulator
H5647_RS00945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H5647_RS00960	COG1858	cytochrome C peroxidase
H5647_RS01030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5647_RS01030	COG1116	anion transmembrane transporter activity
H5647_RS01040	COG1116	anion transmembrane transporter activity
H5647_RS01040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5647_RS01050	COG2373	Large extracellular alpha-helical protein
H5647_RS01055	COG4953	penicillin-binding protein 1C
H5647_RS01065	COG0069	glutamate synthase activity
H5647_RS01070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H5647_RS01075	COG2501	S4 domain
H5647_RS01080	COG0084	hydrolase, TatD family'
H5647_RS01110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H5647_RS01125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H5647_RS01150	COG1595	DNA-templated transcription, initiation
H5647_RS01160	COG3272	Protein of unknown function (DUF1722)
H5647_RS01165	COG2205	protein histidine kinase activity
H5647_RS01165	COG5002	protein histidine kinase activity
H5647_RS01165	COG0784	Response regulator, receiver
H5647_RS01185	COG0823	Involved in the tonB-independent uptake of proteins
H5647_RS01195	COG0243	molybdopterin cofactor binding
H5647_RS01205	COG2205	protein histidine kinase activity
H5647_RS01205	COG0745	RESPONSE REGULATOR receiver
H5647_RS01205	COG3292	Two component regulator propeller
H5647_RS01210	COG0205	6-phosphofructokinase activity
H5647_RS01250	COG0298	carbon dioxide binding
H5647_RS01270	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H5647_RS01275	COG0309	Hydrogenase expression formation protein (HypE)
H5647_RS01285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5647_RS01295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H5647_RS01300	COG0321	lipoyl(octanoyl) transferase activity
H5647_RS01310	COG1686	Belongs to the peptidase S11 family
H5647_RS01315	COG3291	Pkd domain containing protein
H5647_RS01330	COG2951	lytic endotransglycosylase activity
H5647_RS01335	COG0772	Belongs to the SEDS family
H5647_RS01340	COG0768	penicillin binding
H5647_RS01345	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H5647_RS01355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H5647_RS01360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H5647_RS01375	COG4067	protein conserved in archaea
H5647_RS01375	COG0189	ligase activity
H5647_RS01380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5647_RS01410	COG2409	Drug exporters of the RND superfamily
H5647_RS01420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5647_RS01430	COG0784	Response regulator, receiver
H5647_RS01430	COG2205	protein histidine kinase activity
H5647_RS01430	COG5002	protein histidine kinase activity
H5647_RS01435	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H5647_RS01440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H5647_RS01455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5647_RS01460	COG1876	peptidase activity
H5647_RS01475	COG1489	DNA binding
H5647_RS01480	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H5647_RS01485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5647_RS01495	COG3852	Histidine kinase
H5647_RS01500	COG2204	response regulator
H5647_RS01505	COG0617	tRNA 3'-terminal CCA addition
H5647_RS01515	COG1428	Deoxynucleoside kinase
H5647_RS01520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H5647_RS01525	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H5647_RS01530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H5647_RS01540	COG3300	MHYT domain
H5647_RS01540	COG5001	Diguanylate cyclase
H5647_RS01545	COG1785	Belongs to the alkaline phosphatase family
H5647_RS01560	COG0726	polysaccharide deacetylase
H5647_RS01565	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H5647_RS01575	COG2319	Wd-40 repeat
H5647_RS01575	COG4249	Peptidase C14 caspase catalytic subunit p20
H5647_RS01580	COG0534	Mate efflux family protein
H5647_RS01590	COG1047	Peptidyl-prolyl cis-trans
H5647_RS01595	COG0534	Mate efflux family protein
H5647_RS01610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5647_RS01640	COG4221	oxidoreductase activity
H5647_RS01660	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H5647_RS01665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5647_RS01680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H5647_RS01730	COG4989	oxidoreductase activity
H5647_RS01735	COG0514	ATP-dependent DNA helicase (RecQ)
H5647_RS01750	COG3034	peptidoglycan biosynthetic process
H5647_RS01770	COG1217	gtp-binding protein TYPA
H5647_RS01800	COG2203	Gaf domain
H5647_RS01800	COG4251	negative regulation of phosphorylation
H5647_RS01800	COG5001	Diguanylate cyclase
H5647_RS01800	COG3706	GGDEF domain
H5647_RS01805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5647_RS01820	COG2942	2-epimerase
H5647_RS01825	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
H5647_RS01830	COG1609	Transcriptional regulator
H5647_RS01850	COG0301	tRNA thio-modification
H5647_RS01850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5647_RS01865	COG3852	Histidine kinase
H5647_RS01880	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H5647_RS01890	COG0588	phosphoglycerate mutase activity
H5647_RS01895	COG4942	peptidase
H5647_RS01900	COG0793	Belongs to the peptidase S41A family
H5647_RS01905	COG2861	carbohydrate metabolic process
H5647_RS01920	COG0745	RESPONSE REGULATOR receiver
H5647_RS01925	COG2205	protein histidine kinase activity
H5647_RS01930	COG0107	imidazoleglycerol-phosphate synthase activity
H5647_RS01935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H5647_RS01940	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H5647_RS01945	COG0131	Imidazoleglycerol-phosphate dehydratase
H5647_RS01955	COG0438	transferase activity, transferring glycosyl groups
H5647_RS01960	COG2226	methyltransferase
H5647_RS01985	COG3008	intermembrane lipid transfer
H5647_RS01985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5647_RS01990	COG2995	paraquat-inducible protein a
H5647_RS01995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5647_RS02000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5647_RS02005	COG0006	proline dipeptidase activity
H5647_RS02030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H5647_RS02045	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H5647_RS02050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5647_RS02055	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H5647_RS02060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5647_RS02075	COG0126	phosphoglycerate kinase activity
H5647_RS02080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H5647_RS02085	COG0640	Transcriptional regulator
H5647_RS02090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H5647_RS02095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H5647_RS02100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H5647_RS02105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H5647_RS02115	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H5647_RS02130	COG1882	Formate acetyltransferase
H5647_RS02135	COG0431	NADPH-dependent FMN reductase
H5647_RS02140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5647_RS02155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H5647_RS02155	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H5647_RS02160	COG0745	RESPONSE REGULATOR receiver
H5647_RS02165	COG0129	dihydroxy-acid dehydratase activity
H5647_RS02180	COG0848	biopolymer transport protein
H5647_RS02185	COG0811	peptide transport
H5647_RS02190	COG0811	peptide transport
H5647_RS02205	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H5647_RS02210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H5647_RS02215	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
H5647_RS02220	COG1051	belongs to the nudix hydrolase family
H5647_RS02240	COG0840	transmembrane signaling receptor activity
H5647_RS02255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H5647_RS02265	COG0509	glycine decarboxylation via glycine cleavage system
H5647_RS02275	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H5647_RS02290	COG3693	PFAM glycoside hydrolase, family 10
H5647_RS02300	COG3038	cytochrome b561
H5647_RS02305	COG3279	Response regulator of the LytR AlgR family
H5647_RS02315	COG3064	Membrane
H5647_RS02355	COG0494	nUDIX hydrolase
H5647_RS02360	COG1011	Hydrolase
H5647_RS02365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H5647_RS02370	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H5647_RS02380	COG2201	protein-glutamate methylesterase activity
H5647_RS02385	COG0784	Response regulator, receiver
H5647_RS02385	COG2198	Histidine kinase
H5647_RS02385	COG0643	Histidine kinase
H5647_RS02425	COG1678	Uncharacterized ACR, COG1678
H5647_RS02430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H5647_RS02465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5647_RS02470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5647_RS02470	COG2813	Specifically methylates the guanine in position
H5647_RS02480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H5647_RS02505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5647_RS02510	COG0784	Response regulator, receiver
H5647_RS02510	COG2205	protein histidine kinase activity
H5647_RS02510	COG5002	protein histidine kinase activity
H5647_RS02535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H5647_RS02560	COG2959	enzyme of heme biosynthesis
H5647_RS02570	COG0181	hydroxymethylbilane synthase activity
H5647_RS02580	COG3275	phosphorelay sensor kinase activity
H5647_RS02585	COG0165	Argininosuccinate lyase
H5647_RS02590	COG0708	Exodeoxyribonuclease III
H5647_RS02595	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H5647_RS02605	COG1309	transcriptional regulator
H5647_RS02610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H5647_RS02620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H5647_RS02625	COG2003	Belongs to the UPF0758 family
H5647_RS02630	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS02635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H5647_RS02640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H5647_RS02645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H5647_RS02655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H5647_RS02660	COG1561	YicC-like family, N-terminal region
H5647_RS02665	COG0194	GDP metabolic process
H5647_RS02670	COG1758	RNA polymerase activity
H5647_RS02675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5647_RS02685	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5647_RS02690	COG2045	Belongs to the ComB family
H5647_RS02700	COG0778	Nitroreductase
H5647_RS02700	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
H5647_RS02715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H5647_RS02725	COG3738	Protein conserved in bacteria
H5647_RS02755	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H5647_RS02765	COG1301	dicarboxylic acid transport
H5647_RS02795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H5647_RS02820	COG0745	RESPONSE REGULATOR receiver
H5647_RS02825	COG3022	response to hydroperoxide
H5647_RS02835	COG0501	Belongs to the peptidase M48B family
H5647_RS02855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5647_RS02865	COG0573	inorganic phosphate transmembrane transporter activity
H5647_RS02880	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H5647_RS02890	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H5647_RS02895	COG0210	DNA helicase
H5647_RS02910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H5647_RS02945	COG2017	converts alpha-aldose to the beta-anomer
H5647_RS02960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5647_RS02970	COG1136	(ABC) transporter
H5647_RS02970	COG0577	efflux transmembrane transporter activity
H5647_RS02975	COG1136	(ABC) transporter
H5647_RS02990	COG3693	PFAM glycoside hydrolase, family 10
H5647_RS03005	COG4948	Mandelate Racemase Muconate Lactonizing
H5647_RS03045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H5647_RS03045	COG0517	IMP dehydrogenase activity
H5647_RS03055	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5647_RS03065	COG2205	protein histidine kinase activity
H5647_RS03065	COG2198	Histidine kinase
H5647_RS03065	COG0784	Response regulator, receiver
H5647_RS03070	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H5647_RS03090	COG2193	ferroxidase activity
H5647_RS03115	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS03255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H5647_RS03260	COG1349	DNA-binding transcription factor activity
H5647_RS03270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H5647_RS03310	COG4771	TonB-dependent receptor
H5647_RS03320	COG0438	transferase activity, transferring glycosyl groups
H5647_RS03375	COG3250	beta-galactosidase activity
H5647_RS03380	COG2721	sulfolactate sulfo-lyase activity
H5647_RS03520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H5647_RS03525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H5647_RS03530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H5647_RS03535	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H5647_RS03540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H5647_RS03545	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H5647_RS03555	COG0356	it plays a direct role in the translocation of protons across the membrane
H5647_RS03570	COG0625	glutathione transferase activity
H5647_RS03575	COG1475	DNA binding
H5647_RS03580	COG1192	Involved in chromosome partitioning
H5647_RS03585	COG0357	Ribosomal RNA small subunit methyltransferase G
H5647_RS03590	COG3279	Response regulator of the LytR AlgR family
H5647_RS03595	COG3275	phosphorelay sensor kinase activity
H5647_RS03615	COG0445	tRNA wobble uridine modification
H5647_RS03620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H5647_RS03625	COG0706	membrane insertase activity
H5647_RS03630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H5647_RS03635	COG0594	ribonuclease P activity
H5647_RS03640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H5647_RS03645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H5647_RS03650	COG0592	DNA-directed DNA polymerase activity
H5647_RS03655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5647_RS03685	COG2824	Alkylphosphonate utilization operon protein PhnA
H5647_RS03695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5647_RS03750	COG0751	glycine-tRNA ligase activity
H5647_RS03755	COG0752	glycyl-tRNA synthetase alpha subunit
H5647_RS03770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5647_RS03775	COG0569	domain protein
H5647_RS03790	COG0242	peptide deformylase activity
H5647_RS03810	COG0009	L-threonylcarbamoyladenylate synthase
H5647_RS03815	COG0408	coproporphyrinogen oxidase activity
H5647_RS03820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H5647_RS03835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5647_RS03840	COG1121	(ABC) transporter
H5647_RS03845	COG0735	belongs to the Fur family
H5647_RS03850	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H5647_RS03860	COG2885	chlorophyll binding
H5647_RS03860	COG3047	cAMP biosynthetic process
H5647_RS03870	COG1278	Cold shock
H5647_RS03885	COG0534	Mate efflux family protein
H5647_RS03895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5647_RS03905	COG1845	cytochrome c oxidase, subunit III
H5647_RS03915	COG3346	SURF1 family
H5647_RS03925	COG1612	heme a metabolic process
H5647_RS03930	COG0109	protoheme IX farnesyltransferase activity
H5647_RS03960	COG1312	Catalyzes the dehydration of D-mannonate
H5647_RS03965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H5647_RS03980	COG2706	6-phosphogluconolactonase activity
H5647_RS03985	COG0667	Aldo Keto reductase
H5647_RS03995	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H5647_RS04020	COG0784	Response regulator, receiver
H5647_RS04020	COG5002	protein histidine kinase activity
H5647_RS04020	COG2205	protein histidine kinase activity
H5647_RS04035	COG2081	HI0933 family
H5647_RS04070	COG2801	Transposase and inactivated derivatives
H5647_RS04105	COG2819	hydrolase of the alpha beta superfamily
H5647_RS04255	COG4372	Transposase
H5647_RS04305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5647_RS04390	COG0513	Belongs to the DEAD box helicase family
H5647_RS04420	COG2962	Rard protein
H5647_RS04425	COG2827	Endonuclease containing a URI domain
H5647_RS04430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H5647_RS04435	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS04445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5647_RS04460	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H5647_RS04470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H5647_RS04480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5647_RS04505	COG1215	transferase activity, transferring glycosyl groups
H5647_RS04510	COG0438	transferase activity, transferring glycosyl groups
H5647_RS04530	COG1216	Glycosyl transferase, family 2
H5647_RS04535	COG2244	polysaccharide biosynthetic process
H5647_RS04540	COG1215	transferase activity, transferring glycosyl groups
H5647_RS04560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H5647_RS04580	COG0726	polysaccharide deacetylase
H5647_RS04590	COG0367	asparagine synthase
H5647_RS04595	COG0297	glycogen (starch) synthase activity
H5647_RS04650	COG0210	DNA helicase
H5647_RS04655	COG0606	chelatase, subunit chli
H5647_RS04665	COG0829	nickel cation binding
H5647_RS04670	COG0831	urea catabolic process
H5647_RS04675	COG0832	Belongs to the urease beta subunit family
H5647_RS04680	COG0804	urea catabolic process
H5647_RS04685	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H5647_RS04690	COG0830	nickel cation binding
H5647_RS04695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H5647_RS04720	COG0411	ABC transporter
H5647_RS04970	COG2801	Transposase and inactivated derivatives
H5647_RS04985	COG2801	Transposase and inactivated derivatives
H5647_RS04995	COG2801	Transposase and inactivated derivatives
H5647_RS05025	COG2801	Transposase and inactivated derivatives
H5647_RS05095	COG2197	response regulator
H5647_RS05100	COG4585	Histidine kinase
H5647_RS05130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS05140	COG0347	Belongs to the P(II) protein family
H5647_RS05145	COG0004	ammonium transporteR
H5647_RS05150	COG0347	Belongs to the P(II) protein family
H5647_RS05165	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H5647_RS05185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H5647_RS05190	COG0742	ribosomal rna small subunit methyltransferase
H5647_RS05195	COG0552	protein localization to endoplasmic reticulum
H5647_RS05200	COG2884	Cell division ATP-binding protein ftsE
H5647_RS05205	COG2177	Part of the ABC transporter FtsEX involved in
H5647_RS05220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H5647_RS05260	COG2918	glutathione biosynthetic process
H5647_RS05270	COG3031	protein transport across the cell outer membrane
H5647_RS05305	COG4795	General secretion pathway protein
H5647_RS05310	COG3156	type II secretion system protein K
H5647_RS05315	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H5647_RS05365	COG0811	peptide transport
H5647_RS05400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5647_RS05435	COG1846	Transcriptional regulator
H5647_RS05450	COG2183	response to ionizing radiation
H5647_RS05455	COG1538	Outer membrane efflux protein
H5647_RS05460	COG0494	nUDIX hydrolase
H5647_RS05470	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H5647_RS05475	COG3150	esterase
H5647_RS05485	COG2217	Heavy metal translocating P-type atpase
H5647_RS05510	COG1879	ABC-type sugar transport system periplasmic component
H5647_RS05515	COG1129	ABC transporter
H5647_RS05520	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5647_RS05525	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5647_RS05530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5647_RS05550	COG2160	L-arabinose isomerase activity
H5647_RS05555	COG2186	Transcriptional regulator
H5647_RS05565	COG1671	Belongs to the UPF0178 family
H5647_RS05575	COG0589	response to stress
H5647_RS05580	COG0659	secondary active sulfate transmembrane transporter activity
H5647_RS05595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5647_RS05605	COG1519	Transferase
H5647_RS05610	COG1132	(ABC) transporter
H5647_RS05620	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H5647_RS05625	COG0840	transmembrane signaling receptor activity
H5647_RS05630	COG3706	GGDEF domain
H5647_RS05640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5647_RS05650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5647_RS05685	COG2304	oxidoreductase activity
H5647_RS05700	COG2022	thiamine diphosphate biosynthetic process
H5647_RS05720	COG3012	SEC-C Motif Domain Protein
H5647_RS05725	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H5647_RS05730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H5647_RS05740	COG4452	Inner membrane protein CreD
H5647_RS05755	COG1714	RDD family
H5647_RS05805	COG1136	(ABC) transporter
H5647_RS05820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5647_RS05835	COG0488	(ABC) transporter
H5647_RS05845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5647_RS05850	COG4067	protein conserved in archaea
H5647_RS05850	COG0189	ligase activity
H5647_RS05855	COG0598	Magnesium transport protein CorA
H5647_RS05860	COG3264	Mechanosensitive ion channel
H5647_RS05860	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H5647_RS05870	COG0189	ligase activity
H5647_RS05880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H5647_RS05885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5647_RS05885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5647_RS05900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H5647_RS05905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5647_RS05915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H5647_RS05925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5647_RS05945	COG0745	RESPONSE REGULATOR receiver
H5647_RS05950	COG5002	protein histidine kinase activity
H5647_RS05955	COG5002	protein histidine kinase activity
H5647_RS05970	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H5647_RS05975	COG0281	malic enzyme
H5647_RS05990	COG0583	DNA-binding transcription factor activity
H5647_RS06010	COG5265	(ABC) transporter
H5647_RS06040	COG0432	Pfam Uncharacterised protein family UPF0047
H5647_RS06045	COG1132	(ABC) transporter
H5647_RS06055	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5647_RS06055	COG1024	Enoyl-CoA hydratase
H5647_RS06080	COG0840	transmembrane signaling receptor activity
H5647_RS06080	COG2203	Gaf domain
H5647_RS06085	COG2198	Histidine kinase
H5647_RS06085	COG0643	Histidine kinase
H5647_RS06110	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H5647_RS06115	COG2972	Histidine kinase
H5647_RS06140	COG1466	dna polymerase III delta subunit
H5647_RS06150	COG0495	leucyl-tRNA aminoacylation
H5647_RS06160	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H5647_RS06170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H5647_RS06180	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H5647_RS06185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5647_RS06190	COG1492	cobalamin metabolic process
H5647_RS06215	COG2010	Cytochrome c
H5647_RS06220	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H5647_RS06230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H5647_RS06235	COG1702	phosphate starvation-inducible protein PhoH
H5647_RS06240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5647_RS06250	COG0596	Alpha beta hydrolase
H5647_RS06265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5647_RS06270	COG2119	membrane
H5647_RS06315	COG1596	polysaccharide export
H5647_RS06345	COG0463	Glycosyl transferase, family 2
H5647_RS06345	COG1216	Glycosyl transferase, family 2
H5647_RS06350	COG4191	Histidine kinase
H5647_RS06380	COG0193	aminoacyl-tRNA hydrolase activity
H5647_RS06385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H5647_RS06390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5647_RS06400	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H5647_RS06415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H5647_RS06420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H5647_RS06440	COG4774	siderophore transport
H5647_RS06455	COG0513	Belongs to the DEAD box helicase family
H5647_RS06460	COG0745	RESPONSE REGULATOR receiver
H5647_RS06480	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5647_RS06485	COG0154	amidase activity
H5647_RS06490	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5647_RS06495	COG1077	Cell shape determining protein MreB Mrl
H5647_RS06500	COG1792	Involved in formation and maintenance of cell shape
H5647_RS06510	COG0424	maF-like protein
H5647_RS06525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5647_RS06605	COG0358	DNA primase activity
H5647_RS06620	COG3028	Belongs to the UPF0307 family
H5647_RS06625	COG2239	Acts as a magnesium transporter
H5647_RS06635	COG1660	Displays ATPase and GTPase activities
H5647_RS06650	COG1137	ATPase activity
H5647_RS06665	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H5647_RS06685	COG0271	Belongs to the BolA IbaG family
H5647_RS06690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H5647_RS06695	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H5647_RS06700	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H5647_RS06705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H5647_RS06730	COG1053	succinate dehydrogenase
H5647_RS06735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5647_RS06750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5647_RS06760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H5647_RS06770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H5647_RS06775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H5647_RS06780	COG0723	plastoquinol--plastocyanin reductase activity
H5647_RS06785	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H5647_RS06790	COG0625	glutathione transferase activity
H5647_RS06795	COG2969	positive regulation of protein catabolic process
H5647_RS06810	COG0501	Belongs to the peptidase M48B family
H5647_RS06815	COG1704	LemA family
H5647_RS06820	COG0183	Belongs to the thiolase family
H5647_RS06825	COG2823	Periplasmic or secreted lipoprotein
H5647_RS06830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H5647_RS06860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5647_RS06870	COG2226	methyltransferase
H5647_RS06880	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H5647_RS06885	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H5647_RS06900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H5647_RS06905	COG0254	rRNA binding
H5647_RS06945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H5647_RS06950	COG3266	domain, Protein
H5647_RS06955	COG0067	glutamate synthase
H5647_RS06955	COG0070	glutamate synthase
H5647_RS06955	COG0069	glutamate synthase activity
H5647_RS06960	COG0493	'glutamate synthase
H5647_RS06965	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H5647_RS06970	COG0784	Response regulator, receiver
H5647_RS06970	COG3437	response regulator, receiver
H5647_RS06980	COG0688	phosphatidylethanolamine metabolic process
H5647_RS06990	COG1162	GTPase activity
H5647_RS06995	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H5647_RS07015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H5647_RS07015	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H5647_RS07020	COG0802	atpase or kinase
H5647_RS07025	COG0860	N-Acetylmuramoyl-L-alanine amidase
H5647_RS07030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H5647_RS07035	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H5647_RS07040	COG1923	regulation of RNA biosynthetic process
H5647_RS07045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5647_RS07050	COG0330	HflC and HflK could
H5647_RS07055	COG0330	HflC and HflK could
H5647_RS07065	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H5647_RS07070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H5647_RS07075	COG2205	protein histidine kinase activity
H5647_RS07075	COG2202	Pas domain
H5647_RS07090	COG0527	aspartate kinase activity
H5647_RS07105	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H5647_RS07110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H5647_RS07115	COG1607	acyl-coa hydrolase
H5647_RS07130	COG3530	Putative quorum-sensing-regulated virulence factor
H5647_RS07145	COG1392	Phosphate transport regulator
H5647_RS07150	COG0306	phosphate transporter
H5647_RS07175	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H5647_RS07190	COG1254	Belongs to the acylphosphatase family
H5647_RS07225	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H5647_RS07235	COG3148	PFAM DTW domain containing protein
H5647_RS07240	COG1643	Atp-dependent helicase
H5647_RS07285	COG3291	Pkd domain containing protein
H5647_RS07295	COG3634	alkyl hydroperoxide reductase activity
H5647_RS07305	COG3290	protein histidine kinase activity
H5647_RS07310	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H5647_RS07320	COG0798	PFAM Bile acid sodium symporter
H5647_RS07330	COG0640	Transcriptional regulator
H5647_RS07335	COG1309	transcriptional regulator
H5647_RS07350	COG3693	PFAM glycoside hydrolase, family 10
H5647_RS07385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H5647_RS07390	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H5647_RS07450	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H5647_RS07510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5647_RS07515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5647_RS07540	COG0318	PFAM AMP-dependent synthetase and ligase
H5647_RS07560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H5647_RS07570	COG0069	glutamate synthase activity
H5647_RS07570	COG0067	glutamate synthase
H5647_RS07570	COG0070	glutamate synthase
H5647_RS07575	COG0493	'glutamate synthase
H5647_RS07590	COG3321	synthase
H5647_RS07590	COG1028	Short-chain dehydrogenase reductase Sdr
H5647_RS07590	COG0604	alcohol dehydrogenase
H5647_RS07655	COG0084	hydrolase, TatD family'
H5647_RS07675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H5647_RS07740	COG3250	beta-galactosidase activity
H5647_RS07745	COG3775	system Galactitol-specific IIC component
H5647_RS07755	COG1785	Belongs to the alkaline phosphatase family
H5647_RS07760	COG1785	Belongs to the alkaline phosphatase family
H5647_RS07795	COG1278	Cold shock
H5647_RS07800	COG4628	conserved protein (DUF2132)
H5647_RS07815	COG0604	alcohol dehydrogenase
H5647_RS07820	COG3250	beta-galactosidase activity
H5647_RS07850	COG0534	Mate efflux family protein
H5647_RS07860	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS07870	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS07900	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H5647_RS07920	COG0318	PFAM AMP-dependent synthetase and ligase
H5647_RS07965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5647_RS07970	COG0318	PFAM AMP-dependent synthetase and ligase
H5647_RS07985	COG0562	UDP-galactopyranose mutase
H5647_RS08010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5647_RS08015	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5647_RS08025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5647_RS08030	COG1116	anion transmembrane transporter activity
H5647_RS08045	COG0439	Biotin carboxylase
H5647_RS08110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H5647_RS08115	COG0720	synthase
H5647_RS08180	COG0582	viral genome integration into host DNA
H5647_RS08195	COG1131	(ABC) transporter
H5647_RS08215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H5647_RS08225	COG0071	Belongs to the small heat shock protein (HSP20) family
H5647_RS08235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5647_RS08250	COG2203	Gaf domain
H5647_RS08250	COG2199	diguanylate cyclase activity
H5647_RS08280	COG1401	restriction endodeoxyribonuclease activity
H5647_RS08285	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H5647_RS08300	COG0732	type I restriction modification DNA specificity domain
H5647_RS08305	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H5647_RS08320	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H5647_RS08325	COG0733	neurotransmitter:sodium symporter activity
H5647_RS08330	COG2867	negative regulation of translational initiation
H5647_RS08335	COG2914	Belongs to the UPF0125 (RnfH) family
H5647_RS08340	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5647_RS08350	COG0497	DNA recombination
H5647_RS08355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H5647_RS08360	COG0443	Heat shock 70 kDa protein
H5647_RS08365	COG0484	heat shock protein binding
H5647_RS08370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H5647_RS08380	COG0505	Belongs to the CarA family
H5647_RS08385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H5647_RS08390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5647_RS08395	COG0745	RESPONSE REGULATOR receiver
H5647_RS08400	COG2205	protein histidine kinase activity
H5647_RS08410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H5647_RS08415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5647_RS08420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H5647_RS08425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5647_RS08430	COG0149	triose-phosphate isomerase activity
H5647_RS08435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H5647_RS08450	COG0779	Required for maturation of 30S ribosomal subunits
H5647_RS08455	COG2251	uridine kinase activity
H5647_RS08455	COG0195	Participates in both transcription termination and antitermination
H5647_RS08460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H5647_RS08465	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H5647_RS08470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H5647_RS08475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H5647_RS08480	COG1185	polyribonucleotide nucleotidyltransferase activity
H5647_RS08490	COG3132	Protein of unknown function, DUF480
H5647_RS08505	COG2755	lipolytic protein G-D-S-L family
H5647_RS08515	COG4191	Histidine kinase
H5647_RS08525	COG1984	allophanate hydrolase subunit 2
H5647_RS08530	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H5647_RS08535	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H5647_RS08545	COG1490	D-aminoacyl-tRNA deacylase activity
H5647_RS08560	COG0745	RESPONSE REGULATOR receiver
H5647_RS08565	COG2205	protein histidine kinase activity
H5647_RS08570	COG0596	Alpha beta hydrolase
H5647_RS08575	COG2818	Glycosylase
H5647_RS08585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5647_RS08590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5647_RS08595	COG0140	phosphoribosyl-ATP diphosphatase activity
H5647_RS08600	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H5647_RS08605	COG0142	geranyltranstransferase activity
H5647_RS08615	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H5647_RS08630	COG0583	DNA-binding transcription factor activity
H5647_RS08645	COG0501	Belongs to the peptidase M48B family
H5647_RS08655	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5647_RS08670	COG4555	ABC transporter
H5647_RS08685	COG2223	nitrite transmembrane transporter activity
H5647_RS08690	COG2223	nitrite transmembrane transporter activity
H5647_RS08695	COG2815	serine threonine protein kinase
H5647_RS08695	COG0515	serine threonine protein kinase
H5647_RS08705	COG2197	response regulator
H5647_RS08710	COG2223	nitrite transmembrane transporter activity
H5647_RS08715	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
H5647_RS08725	COG3850	Histidine kinase
H5647_RS08730	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H5647_RS08735	COG1140	nitrate reductase beta subunit
H5647_RS08740	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H5647_RS08745	COG2181	nitrate reductase activity
H5647_RS08800	COG2954	triphosphatase activity
H5647_RS08985	COG2801	Transposase and inactivated derivatives
H5647_RS09220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5647_RS09235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H5647_RS09250	COG1215	transferase activity, transferring glycosyl groups
H5647_RS09265	COG1610	YqeY-like protein
H5647_RS09270	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H5647_RS09275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5647_RS09280	COG1620	l-lactate permease
H5647_RS09285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H5647_RS09295	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H5647_RS09310	COG0617	tRNA 3'-terminal CCA addition
H5647_RS09320	COG2719	SpoVR family
H5647_RS09325	COG2718	Belongs to the UPF0229 family
H5647_RS09330	COG2766	serine protein kinase
H5647_RS09335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5647_RS09340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H5647_RS09345	COG2967	ApaG domain
H5647_RS09350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H5647_RS09355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H5647_RS09360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5647_RS09365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H5647_RS09370	COG3178	'Phosphotransferase
H5647_RS09375	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H5647_RS09385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H5647_RS09400	COG2204	response regulator
H5647_RS09405	COG2198	Histidine kinase
H5647_RS09405	COG2205	protein histidine kinase activity
H5647_RS09405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5647_RS09405	COG0784	Response regulator, receiver
H5647_RS09415	COG0512	Glutamine amidotransferase of anthranilate synthase
H5647_RS09420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H5647_RS09425	COG0134	indole-3-glycerol-phosphate synthase activity
H5647_RS09435	COG1765	OsmC-like protein
H5647_RS09450	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H5647_RS09455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5647_RS09460	COG0668	transmembrane transport
H5647_RS09475	COG1203	CRISPR-associated helicase, Cas3
H5647_RS09520	COG0138	bifunctional purine biosynthesis protein purh
H5647_RS09525	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H5647_RS09540	COG2264	protein methyltransferase activity
H5647_RS09550	COG0511	ligase activity, forming carbon-carbon bonds
H5647_RS09555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H5647_RS09560	COG4232	protein-disulfide reductase activity
H5647_RS09585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5647_RS09600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H5647_RS09610	COG1981	membrane
H5647_RS09620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H5647_RS09635	COG0316	Belongs to the HesB IscA family
H5647_RS09650	COG2205	protein histidine kinase activity
H5647_RS09650	COG2202	Pas domain
H5647_RS09655	COG4771	TonB-dependent receptor
H5647_RS09660	COG2001	Belongs to the MraZ family
H5647_RS09665	COG0275	rRNA processing
H5647_RS09680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H5647_RS09685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H5647_RS09690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H5647_RS09695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H5647_RS09700	COG0772	Belongs to the SEDS family
H5647_RS09705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H5647_RS09710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5647_RS09715	COG1181	Belongs to the D-alanine--D-alanine ligase family
H5647_RS09720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H5647_RS09735	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H5647_RS09740	COG0739	heme binding
H5647_RS09745	COG0653	protein targeting
H5647_RS09750	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H5647_RS09755	COG0494	nUDIX hydrolase
H5647_RS09765	COG0237	dephospho-CoA kinase activity
H5647_RS09770	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H5647_RS09820	COG3577	Aspartyl protease
H5647_RS09830	COG3023	N-Acetylmuramoyl-L-alanine amidase
H5647_RS09840	COG2211	Major facilitator Superfamily
H5647_RS09845	COG3030	protein affecting phage T7 exclusion by the F plasmid
H5647_RS09850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H5647_RS09855	COG0459	protein refolding
H5647_RS09880	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H5647_RS09880	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H5647_RS09885	COG2154	pterin-4-alpha-carbinolamine dehydratase
H5647_RS09905	COG1309	transcriptional regulator
H5647_RS09910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H5647_RS09915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H5647_RS09925	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H5647_RS09945	COG0616	signal peptide processing
H5647_RS09960	COG1393	Belongs to the ArsC family
H5647_RS09965	COG1295	ribonuclease BN
H5647_RS09970	COG3437	response regulator, receiver
H5647_RS09975	COG3977	Valine--pyruvate aminotransferase
H5647_RS09980	COG3265	gluconokinase activity
H5647_RS09985	COG1609	Transcriptional regulator
H5647_RS09990	COG2211	Major facilitator Superfamily
H5647_RS09995	COG3459	Glycosyltransferase 36 associated
H5647_RS10010	COG0463	Glycosyl transferase, family 2
H5647_RS10035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5647_RS10040	COG0418	dihydroorotase activity
H5647_RS10050	COG0390	transport system, permease component
H5647_RS10055	COG0137	argininosuccinate synthase activity
H5647_RS10060	COG3278	Belongs to the heme-copper respiratory oxidase family
H5647_RS10075	COG2010	Cytochrome c
H5647_RS10090	COG2217	Heavy metal translocating P-type atpase
H5647_RS10115	COG0346	lactoylglutathione lyase activity
H5647_RS10120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5647_RS10120	COG0512	Glutamine amidotransferase of anthranilate synthase
H5647_RS10130	COG4660	Part of a membrane complex involved in electron transport
H5647_RS10135	COG4659	FMN binding
H5647_RS10140	COG4658	electron transport chain
H5647_RS10145	COG4656	Part of a membrane complex involved in electron transport
H5647_RS10150	COG2878	Part of a membrane complex involved in electron transport
H5647_RS10155	COG4657	Part of a membrane complex involved in electron transport
H5647_RS10160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5647_RS10160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5647_RS10165	COG0489	protein tyrosine kinase activity
H5647_RS10170	COG0717	Belongs to the dCTP deaminase family
H5647_RS10260	COG0288	reversible hydration of carbon dioxide
H5647_RS10265	COG2925	Exonuclease
H5647_RS10275	COG0540	Belongs to the ATCase OTCase family
H5647_RS10295	COG1199	ATP-dependent helicase activity
H5647_RS10300	COG3098	single-species biofilm formation
H5647_RS10310	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H5647_RS10315	COG0018	arginyl-trna synthetase
H5647_RS10320	COG1024	Enoyl-CoA hydratase
H5647_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
H5647_RS10335	COG0247	lactate metabolic process
H5647_RS10335	COG0277	FAD linked oxidase domain protein
H5647_RS10355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5647_RS10355	COG1648	precorrin-2 dehydrogenase activity
H5647_RS10360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5647_RS10370	COG0243	molybdopterin cofactor binding
H5647_RS10375	COG0437	4 iron, 4 sulfur cluster binding
H5647_RS10395	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H5647_RS10400	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H5647_RS10405	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H5647_RS10410	COG0709	Synthesizes selenophosphate from selenide and ATP
H5647_RS10420	COG0243	molybdopterin cofactor binding
H5647_RS10425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5647_RS10435	COG0745	RESPONSE REGULATOR receiver
H5647_RS10445	COG0640	Transcriptional regulator
H5647_RS10450	COG0840	transmembrane signaling receptor activity
H5647_RS10460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5647_RS10470	COG0837	glucose binding
H5647_RS10480	COG1472	Belongs to the glycosyl hydrolase 3 family
H5647_RS10485	COG0587	DNA-directed DNA polymerase activity
H5647_RS10495	COG4447	cellulose binding
H5647_RS10495	COG5520	Belongs to the glycosyl hydrolase 30 family
H5647_RS10495	COG3291	Pkd domain containing protein
H5647_RS10530	COG1940	carbohydrate kinase activity
H5647_RS10550	COG2815	serine threonine protein kinase
H5647_RS10550	COG0515	serine threonine protein kinase
H5647_RS10555	COG2223	nitrite transmembrane transporter activity
H5647_RS10565	COG0515	serine threonine protein kinase
H5647_RS10570	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H5647_RS10575	COG2116	formate transmembrane transporter activity
H5647_RS10590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5647_RS10595	COG4771	TonB-dependent receptor
H5647_RS10610	COG5297	Belongs to the glycosyl hydrolase family 6
H5647_RS10615	COG5297	Belongs to the glycosyl hydrolase family 6
H5647_RS10620	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS10625	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS10630	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS10660	COG0746	molybdenum cofactor guanylyltransferase activity
H5647_RS10665	COG0259	pyridoxamine-phosphate oxidase activity
H5647_RS10670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H5647_RS10675	COG1522	sequence-specific DNA binding
H5647_RS10690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5647_RS10700	COG0037	tRNA processing
H5647_RS10705	COG0504	CTP synthase activity
H5647_RS10715	COG0148	phosphopyruvate hydratase activity
H5647_RS10720	COG0653	protein targeting
H5647_RS10735	COG3710	Transcriptional regulator
H5647_RS10760	COG0435	Glutathione S-transferase
H5647_RS10765	COG2259	Doxx family
H5647_RS10770	COG0583	DNA-binding transcription factor activity
H5647_RS10780	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H5647_RS10790	COG0415	Belongs to the DNA photolyase family
H5647_RS10810	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H5647_RS10820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H5647_RS10825	COG0585	pseudouridine synthase activity
H5647_RS10830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H5647_RS10860	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H5647_RS10875	COG2204	response regulator
H5647_RS10885	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H5647_RS10890	COG4804	nuclease activity
H5647_RS10900	COG0732	type I restriction modification DNA specificity domain
H5647_RS10910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H5647_RS10925	COG3279	Response regulator of the LytR AlgR family
H5647_RS10940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H5647_RS10960	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H5647_RS10970	COG1716	ATPase activity
H5647_RS11010	COG1546	Belongs to the CinA family
H5647_RS11015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H5647_RS11030	COG0739	heme binding
H5647_RS11035	COG2835	tetraacyldisaccharide 4'-kinase activity
H5647_RS11040	COG0537	adenosine 5'-monophosphoramidase activity
H5647_RS11045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H5647_RS11055	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H5647_RS11090	COG1476	TRANSCRIPTIONal
H5647_RS11435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5647_RS11460	COG2801	Transposase and inactivated derivatives
H5647_RS11520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5647_RS11540	COG2801	Transposase and inactivated derivatives
H5647_RS11570	COG2801	Transposase and inactivated derivatives
H5647_RS11625	COG2801	Transposase and inactivated derivatives
H5647_RS11680	COG2801	Transposase and inactivated derivatives
H5647_RS11735	COG4372	Transposase
H5647_RS11790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5647_RS11830	COG1803	Methylglyoxal synthase
H5647_RS11835	COG0405	Gamma-glutamyltransferase
H5647_RS11860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5647_RS11865	COG3630	sodium ion export across plasma membrane
H5647_RS11870	COG0511	ligase activity, forming carbon-carbon bonds
H5647_RS11870	COG5016	pyruvate
H5647_RS11875	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H5647_RS11895	COG0271	Belongs to the BolA IbaG family
H5647_RS11900	COG1054	Belongs to the UPF0176 family
H5647_RS11905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5647_RS11915	COG1739	Uncharacterized protein family UPF0029
H5647_RS11930	COG1842	Phage shock protein A
H5647_RS11940	COG1983	PspC domain protein
H5647_RS11970	COG2211	Major facilitator Superfamily
H5647_RS11975	COG3459	Glycosyltransferase 36 associated
H5647_RS11985	COG1028	Short-chain dehydrogenase reductase Sdr
H5647_RS11990	COG3243	poly(R)-hydroxyalkanoic acid synthase
H5647_RS12010	COG1028	Short-chain dehydrogenase reductase Sdr
H5647_RS12015	COG3118	belongs to the thioredoxin family
H5647_RS12025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5647_RS12125	COG2801	Transposase and inactivated derivatives
H5647_RS12175	COG2801	Transposase and inactivated derivatives
H5647_RS12195	COG2801	Transposase and inactivated derivatives
H5647_RS12270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS12285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H5647_RS12290	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H5647_RS12295	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H5647_RS12305	COG3100	YcgL domain-containing protein
H5647_RS12310	COG2983	Belongs to the UPF0260 family
H5647_RS12315	COG2900	Belongs to the SlyX family
H5647_RS12335	COG1169	isochorismate synthase
H5647_RS12340	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H5647_RS12355	COG1441	menaquinone biosynthetic process
H5647_RS12360	COG0318	PFAM AMP-dependent synthetase and ligase
H5647_RS12365	COG2050	protein possibly involved in aromatic compounds catabolism
H5647_RS12370	COG4221	oxidoreductase activity
H5647_RS12375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H5647_RS12375	COG0678	peroxiredoxin activity
H5647_RS12385	COG2211	Major facilitator Superfamily
H5647_RS12405	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H5647_RS12420	COG1472	Belongs to the glycosyl hydrolase 3 family
H5647_RS12440	COG0784	Response regulator, receiver
H5647_RS12450	COG4251	negative regulation of phosphorylation
H5647_RS12465	COG0513	Belongs to the DEAD box helicase family
H5647_RS12485	COG0840	transmembrane signaling receptor activity
H5647_RS12525	COG0525	valine-tRNA ligase activity
H5647_RS12545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H5647_RS12550	COG0795	lipopolysaccharide-transporting ATPase activity
H5647_RS12555	COG0795	lipopolysaccharide-transporting ATPase activity
H5647_RS12580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H5647_RS12585	COG0800	Aldolase
H5647_RS12600	COG2832	Protein of unknown function (DUF454)
H5647_RS12620	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS12625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5647_RS12630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5647_RS12635	COG3291	Pkd domain containing protein
H5647_RS12635	COG5520	Belongs to the glycosyl hydrolase 30 family
H5647_RS12635	COG4447	cellulose binding
H5647_RS12640	COG0826	peptidase U32
H5647_RS12645	COG0826	peptidase U32
H5647_RS12650	COG3154	lipid carrier protein
H5647_RS12665	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H5647_RS12670	COG0343	queuine tRNA-ribosyltransferase activity
H5647_RS12680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5647_RS12690	COG2205	protein histidine kinase activity
H5647_RS12690	COG2198	Histidine kinase
H5647_RS12690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5647_RS12690	COG0784	Response regulator, receiver
H5647_RS12725	COG0719	Fe-S assembly protein
H5647_RS12730	COG0396	ATPase activity
H5647_RS12735	COG0719	Fe-S assembly protein
H5647_RS12740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H5647_RS12745	COG0316	Belongs to the HesB IscA family
H5647_RS12755	COG2166	iron-sulfur cluster assembly
H5647_RS12765	COG0105	UTP biosynthetic process
H5647_RS12770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H5647_RS12785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H5647_RS12790	COG0124	histidyl-tRNA synthetase
H5647_RS12795	COG2976	Protein conserved in bacteria
H5647_RS12805	COG1160	GTP binding
H5647_RS12815	COG1119	ATPase activity
H5647_RS12820	COG0384	phenazine biosynthesis protein PhzF
H5647_RS12830	COG1570	exodeoxyribonuclease VII activity
H5647_RS12840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H5647_RS12840	COG0519	Catalyzes the synthesis of GMP from XMP
H5647_RS12850	COG3094	Invasion gene expression up-regulator, SirB
H5647_RS12860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5647_RS12870	COG0676	glucose-6-phosphate 1-epimerase activity
H5647_RS12875	COG0826	peptidase U32
H5647_RS12890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5647_RS12890	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H5647_RS12915	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H5647_RS12930	COG0667	Aldo Keto reductase
H5647_RS12955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5647_RS12960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5647_RS13030	COG2801	Transposase and inactivated derivatives
H5647_RS13080	COG2819	hydrolase of the alpha beta superfamily
H5647_RS13105	COG3344	reverse transcriptase
H5647_RS13160	COG2815	serine threonine protein kinase
H5647_RS13160	COG0515	serine threonine protein kinase
H5647_RS13230	COG0668	transmembrane transport
H5647_RS13245	COG3040	lipid binding
H5647_RS13315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H5647_RS13355	COG0714	Associated with various cellular activities
H5647_RS13380	COG1131	(ABC) transporter
H5647_RS13390	COG2009	succinate dehydrogenase
H5647_RS13400	COG1053	succinate dehydrogenase
H5647_RS13425	COG0045	succinate-CoA ligase (ADP-forming) activity
H5647_RS13440	COG0326	Molecular chaperone. Has ATPase activity
H5647_RS13445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H5647_RS13455	COG2062	phosphohistidine phosphatase, SixA
H5647_RS13470	COG0302	gtp cyclohydrolase
H5647_RS13480	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H5647_RS13505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H5647_RS13510	COG0066	3-isopropylmalate dehydratase activity
H5647_RS13515	COG0473	3-isopropylmalate dehydrogenase activity
H5647_RS13535	COG0135	phosphoribosylanthranilate isomerase activity
H5647_RS13545	COG0159	tryptophan synthase activity
H5647_RS13550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H5647_RS13555	COG0285	dihydrofolate synthase activity
H5647_RS13575	COG1286	toxin biosynthetic process
H5647_RS13595	COG0714	Associated with various cellular activities
H5647_RS13610	COG0004	ammonium transporteR
H5647_RS13620	COG1584	GPR1 FUN34 yaaH family protein
H5647_RS13625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5647_RS13630	COG0517	IMP dehydrogenase activity
H5647_RS13630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H5647_RS13630	COG0617	tRNA 3'-terminal CCA addition
H5647_RS13640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5647_RS13650	COG2350	Protein conserved in bacteria
H5647_RS13660	COG0613	PHP domain protein
H5647_RS13665	COG0009	L-threonylcarbamoyladenylate synthase
H5647_RS13700	COG0488	(ABC) transporter
H5647_RS13710	COG3706	GGDEF domain
H5647_RS13715	COG0716	FMN binding
H5647_RS13720	COG0500	methyltransferase
H5647_RS13725	COG4106	trans-aconitate 2-methyltransferase activity
H5647_RS13750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5647_RS13770	COG3345	alpha-galactosidase
H5647_RS13845	COG0513	Belongs to the DEAD box helicase family
H5647_RS13875	COG0557	exoribonuclease II activity
H5647_RS13880	COG1278	Cold shock
H5647_RS13905	COG1917	Cupin 2, conserved barrel domain protein
H5647_RS13910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5647_RS13940	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H5647_RS13955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H5647_RS13960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H5647_RS13965	COG0705	Rhomboid family
H5647_RS13975	COG0308	aminopeptidase N
H5647_RS13980	COG3038	cytochrome b561
H5647_RS13995	COG2304	oxidoreductase activity
H5647_RS14000	COG2304	oxidoreductase activity
H5647_RS14015	COG0714	Associated with various cellular activities
H5647_RS14035	COG0784	Response regulator, receiver
H5647_RS14040	COG4251	negative regulation of phosphorylation
H5647_RS14045	COG0167	dihydroorotate dehydrogenase activity
H5647_RS14050	COG3130	regulation of translation
H5647_RS14055	COG0116	Belongs to the methyltransferase superfamily
H5647_RS14055	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H5647_RS14060	COG0556	nucleotide-excision repair
H5647_RS14065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H5647_RS14070	COG0583	DNA-binding transcription factor activity
H5647_RS14085	COG1012	belongs to the aldehyde dehydrogenase family
H5647_RS14085	COG2030	dehydratase
H5647_RS14090	COG0318	PFAM AMP-dependent synthetase and ligase
H5647_RS14115	COG0604	alcohol dehydrogenase
H5647_RS14115	COG3321	synthase
H5647_RS14220	COG2843	Capsule synthesis protein
H5647_RS14225	COG1773	rubredoxin
H5647_RS14235	COG1959	2 iron, 2 sulfur cluster binding
H5647_RS14270	COG0318	PFAM AMP-dependent synthetase and ligase
H5647_RS14275	COG1960	acyl-CoA dehydrogenase activity
H5647_RS14305	COG4771	TonB-dependent receptor
H5647_RS14330	COG0653	protein targeting
H5647_RS14335	COG0523	cobalamin synthesis protein
H5647_RS14530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H5647_RS14535	COG1187	pseudouridine synthase activity
H5647_RS14540	COG2813	Specifically methylates the guanine in position
H5647_RS14560	COG0564	pseudouridine synthase activity
H5647_RS14575	COG0300	oxidoreductase activity
H5647_RS14585	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H5647_RS14590	COG2205	protein histidine kinase activity
H5647_RS14610	COG0215	cysteine-tRNA ligase activity
H5647_RS14615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5647_RS14625	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5647_RS14640	COG4999	Histidine kinase
H5647_RS14640	COG3850	Histidine kinase
H5647_RS14640	COG3437	response regulator, receiver
H5647_RS14640	COG2205	protein histidine kinase activity
H5647_RS14695	COG0330	HflC and HflK could
H5647_RS14700	COG0318	PFAM AMP-dependent synthetase and ligase
H5647_RS14705	COG1960	acyl-CoA dehydrogenase activity
H5647_RS14735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H5647_RS14740	COG3115	cell septum assembly
H5647_RS14745	COG1196	nuclear chromosome segregation
H5647_RS14775	COG0708	Exodeoxyribonuclease III
H5647_RS14815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5647_RS14825	COG1074	ATP-dependent DNA helicase activity
H5647_RS14830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5647_RS14840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H5647_RS14840	COG0316	Belongs to the HesB IscA family
H5647_RS14860	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5647_RS14875	COG0616	signal peptide processing
H5647_RS14885	COG2816	NAD+ diphosphatase activity
H5647_RS14895	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5647_RS14900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5647_RS14905	COG0328	RNA-DNA hybrid ribonuclease activity
H5647_RS14910	COG2226	methyltransferase
H5647_RS14920	COG1388	LysM domain
H5647_RS14920	COG0741	lytic transglycosylase activity
H5647_RS14940	COG0601	transmembrane transport
H5647_RS14945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5647_RS14955	COG3104	oligopeptide transport
H5647_RS14975	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS15045	COG1476	TRANSCRIPTIONal
H5647_RS15060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5647_RS15095	COG0582	viral genome integration into host DNA
H5647_RS15115	COG0322	excinuclease ABC activity
H5647_RS15155	COG0463	Glycosyl transferase, family 2
H5647_RS15160	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H5647_RS15165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H5647_RS15175	COG2202	Pas domain
H5647_RS15175	COG2205	protein histidine kinase activity
H5647_RS15195	COG2957	Belongs to the agmatine deiminase family
H5647_RS15205	COG1138	Cytochrome C-type biogenesis protein
H5647_RS15210	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H5647_RS15225	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5647_RS15230	COG4133	protoheme IX ABC transporter activity
H5647_RS15245	COG3123	guanosine phosphorylase activity
H5647_RS15250	COG0784	Response regulator, receiver
H5647_RS15250	COG5002	protein histidine kinase activity
H5647_RS15250	COG2198	Histidine kinase
H5647_RS15270	COG0443	Heat shock 70 kDa protein
H5647_RS15275	COG4676	Protein conserved in bacteria
H5647_RS15290	COG3693	PFAM glycoside hydrolase, family 10
H5647_RS15295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5647_RS15320	COG2186	Transcriptional regulator
H5647_RS15330	COG0783	Belongs to the Dps family
H5647_RS15340	COG1696	Membrane protein involved in D-alanine export
H5647_RS15355	COG2010	Cytochrome c
H5647_RS15510	COG4372	Transposase
H5647_RS15590	COG3012	SEC-C Motif Domain Protein
H5647_RS15675	COG1648	precorrin-2 dehydrogenase activity
H5647_RS15675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5647_RS15680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H5647_RS15685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H5647_RS15690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H5647_RS15700	COG1674	ftsk spoiiie
H5647_RS15705	COG0492	ferredoxin-NADP+ reductase activity
H5647_RS15710	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H5647_RS15715	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H5647_RS15720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H5647_RS15725	COG0542	response to heat
H5647_RS15730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H5647_RS15735	COG1278	Cold shock
H5647_RS15755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5647_RS15765	COG1477	protein flavinylation
H5647_RS15770	COG2871	sodium ion transport
H5647_RS15775	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H5647_RS15790	COG1805	sodium ion transport
H5647_RS15795	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H5647_RS15800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H5647_RS15810	COG1278	Cold shock
H5647_RS15815	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H5647_RS15820	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H5647_RS15825	COG0668	transmembrane transport
H5647_RS15830	COG1472	Belongs to the glycosyl hydrolase 3 family
H5647_RS15855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5647_RS15890	COG0589	response to stress
H5647_RS15895	COG0488	(ABC) transporter
H5647_RS15900	COG0741	lytic transglycosylase activity
H5647_RS15910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H5647_RS15915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H5647_RS15920	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H5647_RS15925	COG1663	tetraacyldisaccharide 4'-kinase activity
H5647_RS15935	COG0811	peptide transport
H5647_RS15940	COG0658	competence protein
H5647_RS15940	COG2333	competence protein COMEC
H5647_RS15955	COG1136	(ABC) transporter
H5647_RS15980	COG0482	sulfurtransferase activity
H5647_RS15985	COG2915	High frequency lysogenization protein hflD homolog
H5647_RS15995	COG2850	peptidyl-arginine hydroxylation
H5647_RS16025	COG0583	DNA-binding transcription factor activity
H5647_RS16030	COG0730	response to heat
H5647_RS16040	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H5647_RS16045	COG1862	Preprotein translocase
H5647_RS16055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H5647_RS16060	COG0039	L-malate dehydrogenase activity
H5647_RS16070	COG0084	hydrolase, TatD family'
H5647_RS16090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H5647_RS16095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H5647_RS16105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5647_RS16110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5647_RS16125	COG0416	fatty acid biosynthetic process
H5647_RS16130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H5647_RS16135	COG1399	metal-binding, possibly nucleic acid-binding protein
H5647_RS16140	COG0424	maF-like protein
H5647_RS16145	COG0488	(ABC) transporter
H5647_RS16150	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS16160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS16180	COG0546	phosphoglycolate phosphatase activity
H5647_RS16190	COG1530	ribonuclease E activity
H5647_RS16195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H5647_RS16205	COG0564	pseudouridine synthase activity
H5647_RS16270	COG1215	transferase activity, transferring glycosyl groups
H5647_RS16295	COG1216	Glycosyl transferase, family 2
H5647_RS16295	COG1442	glycosyl transferase family 8
H5647_RS16370	COG2801	Transposase and inactivated derivatives
H5647_RS16640	COG2819	hydrolase of the alpha beta superfamily
H5647_RS16665	COG3550	peptidyl-serine autophosphorylation
H5647_RS16695	COG4181	ATPase activity
H5647_RS16710	COG0471	metal ion transport
H5647_RS16735	COG0670	Belongs to the BI1 family
H5647_RS16755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5647_RS16765	COG1322	Protein conserved in bacteria
H5647_RS16770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5647_RS16775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5647_RS16785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H5647_RS16790	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H5647_RS16795	COG0740	serine-type endopeptidase activity
H5647_RS16800	COG0544	peptidyl-prolyl cis-trans isomerase activity
H5647_RS16810	COG0183	Belongs to the thiolase family
H5647_RS16815	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5647_RS16815	COG1024	Enoyl-CoA hydratase
H5647_RS16820	COG1396	sequence-specific DNA binding
H5647_RS16820	COG1917	Cupin 2, conserved barrel domain protein
H5647_RS16830	COG2207	Transcriptional regulator
H5647_RS16840	COG1090	epimerase
H5647_RS16930	COG1166	arginine decarboxylase activity
H5647_RS16950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5647_RS16985	COG0577	efflux transmembrane transporter activity
H5647_RS16985	COG1136	(ABC) transporter
H5647_RS16990	COG0577	efflux transmembrane transporter activity
H5647_RS16990	COG1136	(ABC) transporter
H5647_RS17015	COG0848	biopolymer transport protein
H5647_RS17020	COG0811	peptide transport
H5647_RS17045	COG2862	Uncharacterized protein family, UPF0114
H5647_RS17050	COG4124	Belongs to the glycosyl hydrolase 26 family
H5647_RS17055	COG4999	Histidine kinase
H5647_RS17055	COG2205	protein histidine kinase activity
H5647_RS17055	COG3437	response regulator, receiver
H5647_RS17055	COG3850	Histidine kinase
H5647_RS17060	COG5002	protein histidine kinase activity
H5647_RS17060	COG5001	Diguanylate cyclase
H5647_RS17075	COG1238	metal cluster binding
H5647_RS17095	COG0456	acetyltransferase
H5647_RS17120	COG1028	Short-chain dehydrogenase reductase Sdr
H5647_RS17240	COG0740	serine-type endopeptidase activity
H5647_RS17430	COG0776	regulation of translation
H5647_RS17435	COG0072	phenylalanine-tRNA ligase activity
H5647_RS17440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H5647_RS17445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H5647_RS17450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H5647_RS17455	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H5647_RS17460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H5647_RS17470	COG1596	polysaccharide export
H5647_RS17515	COG1086	Polysaccharide biosynthesis protein
H5647_RS17545	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H5647_RS17555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5647_RS17570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H5647_RS17580	COG0776	regulation of translation
H5647_RS17590	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H5647_RS17600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H5647_RS17605	COG0284	orotidine-5'-phosphate decarboxylase activity
H5647_RS17610	COG1555	photosystem II stabilization
H5647_RS17615	COG2895	sulfate adenylyltransferase (ATP) activity
H5647_RS17620	COG0175	sulfate reduction
H5647_RS17625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H5647_RS17640	COG0402	S-adenosylhomocysteine deaminase activity
H5647_RS17645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5647_RS17650	COG0546	phosphoglycolate phosphatase activity
H5647_RS17655	COG1028	Short-chain dehydrogenase reductase Sdr
H5647_RS17670	COG0835	chemotaxis
H5647_RS17680	COG1192	Involved in chromosome partitioning
H5647_RS17685	COG1360	Flagellar Motor Protein
H5647_RS17690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H5647_RS17695	COG2201	protein-glutamate methylesterase activity
H5647_RS17700	COG0643	Histidine kinase
H5647_RS17700	COG2198	Histidine kinase
H5647_RS17700	COG0784	Response regulator, receiver
H5647_RS17740	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H5647_RS17750	COG1987	bacterial-type flagellum assembly
H5647_RS17790	COG0745	RESPONSE REGULATOR receiver
H5647_RS17800	COG2201	protein-glutamate methylesterase activity
H5647_RS17805	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H5647_RS17810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H5647_RS17815	COG0840	transmembrane signaling receptor activity
H5647_RS17820	COG0835	chemotaxis
H5647_RS17830	COG0745	RESPONSE REGULATOR receiver
H5647_RS17870	COG1677	Flagellar hook-basal body complex protein FliE
H5647_RS17890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H5647_RS17910	COG1516	flagellar protein fliS
H5647_RS17915	COG1086	Polysaccharide biosynthesis protein
H5647_RS17920	COG2089	acid synthase
H5647_RS17930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H5647_RS17935	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H5647_RS17960	COG1334	flagellar protein FlaG
H5647_RS17980	COG4771	TonB-dependent receptor
H5647_RS18070	COG1706	bacterial-type flagellum-dependent cell motility
H5647_RS18085	COG4787	bacterial-type flagellum-dependent cell motility
H5647_RS18095	COG1749	Flagellar hook protein flgE
H5647_RS18110	COG1815	bacterial-type flagellum-dependent cell motility
H5647_RS18120	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H5647_RS18125	COG0784	Response regulator, receiver
H5647_RS18125	COG0835	chemotaxis
H5647_RS18130	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H5647_RS18160	COG0037	tRNA processing
H5647_RS18170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H5647_RS18175	COG0784	Response regulator, receiver
H5647_RS18175	COG2205	protein histidine kinase activity
H5647_RS18185	COG0840	transmembrane signaling receptor activity
H5647_RS18210	COG1362	aminopeptidase activity
H5647_RS18215	COG1968	undecaprenyl-diphosphatase activity
H5647_RS18220	COG1214	PFAM Peptidase M22, glycoprotease
H5647_RS18230	COG0563	adenylate kinase activity
H5647_RS18240	COG3956	TIGRFAM MazG family protein
H5647_RS18245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5647_RS18255	COG5002	protein histidine kinase activity
H5647_RS18255	COG2205	protein histidine kinase activity
H5647_RS18255	COG0784	Response regulator, receiver
H5647_RS18260	COG1381	Involved in DNA repair and RecF pathway recombination
H5647_RS18265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H5647_RS18270	COG0571	ribonuclease III activity
H5647_RS18285	COG0481	GTPase activity
H5647_RS18290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5647_RS18330	COG0354	folic acid binding
H5647_RS18350	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H5647_RS18360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H5647_RS18380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H5647_RS18400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5647_RS18405	COG0335	large ribosomal subunit rRNA binding
H5647_RS18410	COG0336	Belongs to the RNA methyltransferase TrmD family
H5647_RS18415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H5647_RS18420	COG0228	four-way junction DNA binding
H5647_RS18425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H5647_RS18430	COG4137	Cytochrome C assembly protein
H5647_RS18435	COG4536	flavin adenine dinucleotide binding
H5647_RS18495	COG4651	solute:proton antiporter activity
H5647_RS18495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5647_RS18500	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H5647_RS18505	COG1472	Belongs to the glycosyl hydrolase 3 family
H5647_RS18515	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H5647_RS18520	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H5647_RS18555	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H5647_RS18555	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H5647_RS18560	COG0842	Transport permease protein
H5647_RS18565	COG1131	(ABC) transporter
H5647_RS18595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5647_RS18600	COG0436	Aminotransferase
H5647_RS18610	COG5002	protein histidine kinase activity
H5647_RS18610	COG5001	Diguanylate cyclase
H5647_RS18615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H5647_RS18615	COG0116	Belongs to the methyltransferase superfamily
H5647_RS18620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5647_RS18625	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5647_RS18625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5647_RS18630	COG3101	peptidyl-lysine hydroxylation
H5647_RS18640	COG0425	Belongs to the sulfur carrier protein TusA family
H5647_RS18650	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H5647_RS18655	COG0745	RESPONSE REGULATOR receiver
H5647_RS18655	COG3292	Two component regulator propeller
H5647_RS18655	COG2205	protein histidine kinase activity
H5647_RS18680	COG3267	Type II secretory pathway component ExeA
H5647_RS18680	COG3409	Peptidoglycan-binding domain 1 protein
H5647_RS18725	COG1459	type II secretion system
H5647_RS18730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5647_RS18740	COG3409	Peptidoglycan-binding domain 1 protein
H5647_RS18740	COG3267	Type II secretory pathway component ExeA
H5647_RS18770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H5647_RS18775	COG4124	Belongs to the glycosyl hydrolase 26 family
H5647_RS18815	COG0456	acetyltransferase
H5647_RS18820	COG0346	lactoylglutathione lyase activity
H5647_RS18825	COG1942	4-Oxalocrotonate Tautomerase
H5647_RS18835	COG1716	ATPase activity
H5647_RS18840	COG0515	serine threonine protein kinase
H5647_RS18840	COG2815	serine threonine protein kinase
H5647_RS18870	COG1643	Atp-dependent helicase
H5647_RS18880	COG0825	malonyl-CoA metabolic process
H5647_RS18885	COG0587	DNA-directed DNA polymerase activity
H5647_RS18920	COG1183	phosphatidylcholine synthase activity
H5647_RS18925	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H5647_RS18930	COG0583	DNA-binding transcription factor activity
H5647_RS18955	COG2198	Histidine kinase
H5647_RS18955	COG0784	Response regulator, receiver
H5647_RS18955	COG5002	protein histidine kinase activity
H5647_RS18965	COG0028	Belongs to the TPP enzyme family
H5647_RS19000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H5647_RS19000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5647_RS19020	COG2165	general secretion pathway protein
H5647_RS19045	COG4969	Belongs to the N-Me-Phe pilin family
H5647_RS19050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H5647_RS19055	COG1047	Peptidyl-prolyl cis-trans
H5647_RS19060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H5647_RS19065	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H5647_RS19070	COG0196	riboflavin kinase activity
H5647_RS19075	COG0728	peptidoglycan biosynthetic process
H5647_RS19100	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5647_RS19115	COG0425	Belongs to the sulfur carrier protein TusA family
H5647_RS19130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5647_RS19135	COG0023	Translation Initiation Factor
H5647_RS19140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H5647_RS19165	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H5647_RS19170	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5647_RS19175	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5647_RS19180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5647_RS19185	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5647_RS19205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H5647_RS19215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H5647_RS19220	COG0233	cytoplasmic translational termination
H5647_RS19225	COG0528	UMP kinase activity
H5647_RS19230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H5647_RS19235	COG0052	Belongs to the universal ribosomal protein uS2 family
H5647_RS19245	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H5647_RS19250	COG0436	Aminotransferase
H5647_RS19255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H5647_RS19260	COG1393	Belongs to the ArsC family
H5647_RS19270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5647_RS19275	COG0315	cyclic pyranopterin monophosphate synthase activity
H5647_RS19280	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H5647_RS19285	COG0314	molybdopterin synthase activity
H5647_RS19290	COG0742	ribosomal rna small subunit methyltransferase
H5647_RS19295	COG0848	biopolymer transport protein
H5647_RS19330	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H5647_RS19340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5647_RS19345	COG0667	Aldo Keto reductase
H5647_RS19350	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H5647_RS19375	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H5647_RS19380	COG3122	Protein conserved in bacteria
H5647_RS19400	COG0745	RESPONSE REGULATOR receiver
H5647_RS19405	COG2205	protein histidine kinase activity
H5647_RS19410	COG0268	Binds directly to 16S ribosomal RNA
H5647_RS19415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H5647_RS19420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H5647_RS19425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H5647_RS19430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H5647_RS19435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H5647_RS19470	COG0142	geranyltranstransferase activity
H5647_RS19475	COG0166	Belongs to the GPI family
H5647_RS19485	COG3220	belongs to the UPF0276 family
H5647_RS19510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5647_RS19530	COG2814	Major facilitator Superfamily
H5647_RS19535	COG2197	response regulator
H5647_RS19545	COG0297	glycogen (starch) synthase activity
H5647_RS19550	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H5647_RS19555	COG0058	SHG alpha-glucan phosphorylase activity
H5647_RS19565	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H5647_RS19570	COG1640	4-alpha-glucanotransferase
H5647_RS19575	COG0203	ribosomal protein L17
H5647_RS19580	COG0202	RNA polymerase activity
H5647_RS19585	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H5647_RS19590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H5647_RS19595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H5647_RS19600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H5647_RS19610	COG0200	Binds to the 23S rRNA
H5647_RS19615	COG1841	ribosomal large subunit assembly
H5647_RS19620	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H5647_RS19625	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H5647_RS19630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H5647_RS19635	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H5647_RS19640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H5647_RS19645	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H5647_RS19650	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H5647_RS19655	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H5647_RS19660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H5647_RS19665	COG0255	Belongs to the universal ribosomal protein uL29 family
H5647_RS19670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H5647_RS19675	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H5647_RS19680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H5647_RS19685	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H5647_RS19690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H5647_RS19695	COG0089	rRNA binding
H5647_RS19700	COG0088	Forms part of the polypeptide exit tunnel
H5647_RS19705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H5647_RS19710	COG0051	transcription antitermination factor activity, RNA binding
H5647_RS19760	COG0513	Belongs to the DEAD box helicase family
H5647_RS19800	COG0246	Mannitol dehydrogenase
H5647_RS19805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5647_RS19815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H5647_RS19825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H5647_RS19830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H5647_RS19835	COG0049	tRNA binding
H5647_RS19840	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H5647_RS19845	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H5647_RS19850	COG0085	RNA polymerase activity
H5647_RS19855	COG0222	ribosome binding
H5647_RS19860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H5647_RS19865	COG0081	regulation of translation
H5647_RS19870	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H5647_RS19915	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H5647_RS19925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5647_RS19935	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H5647_RS19955	COG0442	prolyl-tRNA aminoacylation
H5647_RS19965	COG0450	alkyl hydroperoxide reductase
H5647_RS19970	COG2906	2 iron, 2 sulfur cluster binding
H5647_RS19980	COG0515	serine threonine protein kinase
H5647_RS19980	COG2815	serine threonine protein kinase
H5647_RS19985	COG1840	ABC-type Fe3 transport system, periplasmic component
H5647_RS19990	COG1178	ABC-type Fe3 transport system permease component
H5647_RS20000	COG4772	TonB-dependent receptor
H5647_RS20030	COG0741	lytic transglycosylase activity
H5647_RS20040	COG3706	GGDEF domain
H5647_RS20050	COG2223	nitrite transmembrane transporter activity
H5647_RS20055	COG3706	GGDEF domain
H5647_RS20060	COG1472	Belongs to the glycosyl hydrolase 3 family
H5647_RS20065	COG3661	Belongs to the glycosyl hydrolase 67 family
H5647_RS20135	COG1115	amino acid carrier protein
H5647_RS20150	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H5647_RS20155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5647_RS20160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H5647_RS20175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5647_RS20205	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5647_RS20205	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5647_RS20225	COG0848	biopolymer transport protein
H5647_RS20230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5647_RS20250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5647_RS20265	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H5647_RS20270	COG0745	RESPONSE REGULATOR receiver
H5647_RS20285	COG0628	permease
H5647_RS20295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H5647_RS20340	COG2308	Evidence 4 Homologs of previously reported genes of
H5647_RS20340	COG2307	Protein conserved in bacteria
H5647_RS20355	COG2308	Evidence 4 Homologs of previously reported genes of
H5647_RS20435	COG1360	Flagellar Motor Protein
H5647_RS20440	COG0189	ligase activity
H5647_RS20440	COG4067	protein conserved in archaea
H5647_RS20445	COG0189	ligase activity
H5647_RS20460	COG0475	glutathione-regulated potassium exporter activity
H5647_RS20470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H5647_RS20485	COG3264	Mechanosensitive ion channel
H5647_RS20485	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H5647_RS20490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5647_RS20505	COG0668	transmembrane transport
H5647_RS20525	COG2239	Acts as a magnesium transporter
H5647_RS20580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5647_RS20585	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H5647_RS20595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H5647_RS20605	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H5647_RS20615	COG0823	Involved in the tonB-independent uptake of proteins
H5647_RS20635	COG2255	four-way junction helicase activity
H5647_RS20640	COG0632	four-way junction helicase activity
H5647_RS20645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H5647_RS20770	COG1475	DNA binding
H5647_RS20775	COG3089	Belongs to the UPF0270 family
H5647_RS20835	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H5647_RS20900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5647_RS20900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H5647_RS20905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5647_RS20975	COG1074	ATP-dependent DNA helicase activity
H5647_RS21055	COG0210	DNA helicase
H5647_RS21125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H5647_RS21155	COG4999	Histidine kinase
H5647_RS21155	COG2205	protein histidine kinase activity
H5647_RS21155	COG3850	Histidine kinase
H5647_RS21155	COG3437	response regulator, receiver
H5647_RS21250	COG0084	hydrolase, TatD family'
H5647_RS21270	COG0750	zinc metalloprotease
H5647_RS21350	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5647_RS21415	COG1201	RNA secondary structure unwinding
H5647_RS21570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5647_RS21690	COG1192	Involved in chromosome partitioning
H5647_RS21700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H5647_RS21700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5647_RS21705	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5647_RS21800	COG3177	Filamentation induced by cAMP protein fic
H5647_RS22010	COG1525	nuclease