locus-tag	class	description
GZ22_RS00040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZ22_RS00045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_RS00050	COG0572	uridine kinase
GZ22_RS00055	COG0446	pyridine nucleotide-disulphide oxidoreductase
GZ22_RS00060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GZ22_RS00065	COG0640	Transcriptional regulator
GZ22_RS00080	COG4412	M6 family metalloprotease domain protein
GZ22_RS00080	COG1404	Belongs to the peptidase S8 family
GZ22_RS00090	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_RS00150	COG0477	Major facilitator Superfamily
GZ22_RS00160	COG1595	DNA-templated transcription, initiation
GZ22_RS00165	COG5662	AntiSigma factor
GZ22_RS00170	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GZ22_RS00175	COG4856	YbbR-like protein
GZ22_RS00180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZ22_RS00185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GZ22_RS00200	COG4585	Histidine kinase
GZ22_RS00205	COG2197	response regulator
GZ22_RS00210	COG1131	(ABC) transporter
GZ22_RS00230	COG3507	Belongs to the glycosyl hydrolase 43 family
GZ22_RS00235	COG5646	InterPro IPR014922
GZ22_RS00240	COG2807	transmembrane transport
GZ22_RS00270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_RS00275	COG2814	Major facilitator Superfamily
GZ22_RS00280	COG0640	Transcriptional regulator
GZ22_RS00285	COG2814	Major facilitator Superfamily
GZ22_RS00310	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS00325	COG0431	NADPH-dependent FMN reductase
GZ22_RS00335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZ22_RS00345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_RS00350	COG0747	negative chemotaxis
GZ22_RS00355	COG0196	riboflavin kinase activity
GZ22_RS00360	COG2873	o-acetylhomoserine
GZ22_RS00370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_RS00375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_RS00380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_RS00385	COG0456	acetyltransferase
GZ22_RS00390	COG0589	response to stress
GZ22_RS00395	COG0659	secondary active sulfate transmembrane transporter activity
GZ22_RS00410	COG1131	(ABC) transporter
GZ22_RS00425	COG0656	L-ascorbic acid biosynthetic process
GZ22_RS00430	COG0656	L-ascorbic acid biosynthetic process
GZ22_RS00455	COG0789	Transcriptional regulator
GZ22_RS00465	COG1929	Belongs to the glycerate kinase type-1 family
GZ22_RS00475	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GZ22_RS00490	COG2112	serine threonine protein kinase
GZ22_RS00505	COG1253	flavin adenine dinucleotide binding
GZ22_RS00510	COG2169	Transcriptional regulator
GZ22_RS00515	COG0673	inositol 2-dehydrogenase activity
GZ22_RS00545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GZ22_RS00570	COG1252	NADH dehydrogenase
GZ22_RS00585	COG1309	transcriptional regulator
GZ22_RS00590	COG0477	Major facilitator Superfamily
GZ22_RS00600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZ22_RS00620	COG3226	Transcriptional regulator
GZ22_RS00630	COG0281	malic enzyme
GZ22_RS00635	COG3711	transcriptional antiterminator
GZ22_RS00640	COG1263	PTS System
GZ22_RS00640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_RS00640	COG2190	(PTS) system
GZ22_RS00645	COG2723	6-phospho-beta-galactosidase activity
GZ22_RS00650	COG4221	oxidoreductase activity
GZ22_RS00660	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_RS00665	COG0702	epimerase
GZ22_RS00675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_RS00680	COG0778	Nitroreductase
GZ22_RS00700	COG5577	PFAM Coat F domain
GZ22_RS00705	COG1063	alcohol dehydrogenase
GZ22_RS00710	COG1737	Transcriptional regulator
GZ22_RS00715	COG1486	melibiose metabolic process
GZ22_RS00720	COG1263	PTS System
GZ22_RS00720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_RS00720	COG2190	(PTS) system
GZ22_RS00735	COG4894	glucomannan catabolic process
GZ22_RS00740	COG0702	epimerase
GZ22_RS00745	COG1289	transmembrane transporter activity
GZ22_RS00755	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GZ22_RS00760	COG1346	cytolysis
GZ22_RS00765	COG1380	Effector of murein hydrolase LrgA
GZ22_RS00770	COG0583	DNA-binding transcription factor activity
GZ22_RS00780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZ22_RS00785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZ22_RS00790	COG1522	sequence-specific DNA binding
GZ22_RS00795	COG0436	Aminotransferase
GZ22_RS00800	COG3711	transcriptional antiterminator
GZ22_RS00805	COG2190	(PTS) system
GZ22_RS00805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_RS00805	COG1263	PTS System
GZ22_RS00810	COG2723	6-phospho-beta-galactosidase activity
GZ22_RS00820	COG1902	pentaerythritol trinitrate reductase activity
GZ22_RS00830	COG3711	transcriptional antiterminator
GZ22_RS00835	COG1263	PTS System
GZ22_RS00835	COG2190	(PTS) system
GZ22_RS00835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_RS00840	COG1733	regulation of RNA biosynthetic process
GZ22_RS00845	COG2814	Major facilitator Superfamily
GZ22_RS00850	COG0656	L-ascorbic acid biosynthetic process
GZ22_RS00865	COG1725	Transcriptional regulator
GZ22_RS00870	COG1131	(ABC) transporter
GZ22_RS00905	COG1177	transmembrane transport
GZ22_RS00910	COG3842	ATPase activity
GZ22_RS00915	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GZ22_RS00920	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS00925	COG0596	Alpha beta hydrolase
GZ22_RS00940	COG0840	transmembrane signaling receptor activity
GZ22_RS00945	COG0840	transmembrane signaling receptor activity
GZ22_RS00950	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS00965	COG1876	peptidase activity
GZ22_RS00970	COG1418	mRNA catabolic process
GZ22_RS00980	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS00985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GZ22_RS00990	COG1970	mechanosensitive ion channel activity
GZ22_RS00995	COG2211	Major facilitator Superfamily
GZ22_RS01005	COG1227	inorganic diphosphatase activity
GZ22_RS01010	COG0667	Aldo Keto reductase
GZ22_RS01015	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GZ22_RS01020	COG1442	glycosyl transferase family 8
GZ22_RS01025	COG1827	regulation of RNA biosynthetic process
GZ22_RS01035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GZ22_RS01040	COG5506	Protein of unknown function (DUF1694)
GZ22_RS01045	COG3842	ATPase activity
GZ22_RS01060	COG2814	Major facilitator Superfamily
GZ22_RS01065	COG0561	phosphatase activity
GZ22_RS01070	COG1132	(ABC) transporter
GZ22_RS01075	COG1473	amidohydrolase
GZ22_RS01080	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GZ22_RS01090	COG0679	Auxin Efflux Carrier
GZ22_RS01095	COG0281	malic enzyme
GZ22_RS01110	COG1733	regulation of RNA biosynthetic process
GZ22_RS01115	COG0590	tRNA wobble adenosine to inosine editing
GZ22_RS01125	COG0492	ferredoxin-NADP+ reductase activity
GZ22_RS01130	COG0561	phosphatase activity
GZ22_RS01135	COG0463	Glycosyl transferase, family 2
GZ22_RS01145	COG4485	Bacterial membrane protein, YfhO
GZ22_RS01150	COG0741	lytic transglycosylase activity
GZ22_RS01160	COG1072	(Pantothenic acid kinase))
GZ22_RS01165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_RS01165	COG1263	PTS System
GZ22_RS01170	COG0366	Alpha amylase catalytic
GZ22_RS01175	COG2188	Transcriptional regulator
GZ22_RS01180	COG1247	-acetyltransferase
GZ22_RS01195	COG2814	Major facilitator Superfamily
GZ22_RS01215	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS01220	COG3871	stress protein (general stress protein 26)
GZ22_RS01225	COG1834	amidinotransferase
GZ22_RS01230	COG1979	alcohol dehydrogenase
GZ22_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS01250	COG1725	Transcriptional regulator
GZ22_RS01255	COG1131	(ABC) transporter
GZ22_RS01260	COG1131	(ABC) transporter
GZ22_RS01265	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GZ22_RS01270	COG1764	response to oxidative stress
GZ22_RS01295	COG1131	(ABC) transporter
GZ22_RS01300	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GZ22_RS01325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GZ22_RS01335	COG0716	FMN binding
GZ22_RS01340	COG0432	Pfam Uncharacterised protein family UPF0047
GZ22_RS01345	COG4251	negative regulation of phosphorylation
GZ22_RS01345	COG3706	GGDEF domain
GZ22_RS01345	COG2203	Gaf domain
GZ22_RS01345	COG5001	Diguanylate cyclase
GZ22_RS01350	COG0840	transmembrane signaling receptor activity
GZ22_RS01360	COG1533	DNA photolyase activity
GZ22_RS01365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GZ22_RS01375	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GZ22_RS01385	COG0352	thiamine-phosphate diphosphorylase activity
GZ22_RS01425	COG0463	Glycosyl transferase, family 2
GZ22_RS01425	COG0457	Tetratricopeptide repeat
GZ22_RS01435	COG2814	Major facilitator Superfamily
GZ22_RS01440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZ22_RS01445	COG0371	Dehydrogenase
GZ22_RS01450	COG0436	Aminotransferase
GZ22_RS01455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZ22_RS01455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZ22_RS01470	COG1181	Belongs to the D-alanine--D-alanine ligase family
GZ22_RS01480	COG0720	synthase
GZ22_RS01485	COG0602	queuosine metabolic process
GZ22_RS01490	COG0137	argininosuccinate synthase activity
GZ22_RS01495	COG0165	Argininosuccinate lyase
GZ22_RS01500	COG0505	Belongs to the CarA family
GZ22_RS01505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GZ22_RS01510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GZ22_RS01530	COG0307	riboflavin synthase, alpha
GZ22_RS01535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZ22_RS01535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZ22_RS01540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GZ22_RS01545	COG0596	Alpha beta hydrolase
GZ22_RS01570	COG0300	oxidoreductase activity
GZ22_RS01580	COG0386	Belongs to the glutathione peroxidase family
GZ22_RS01590	COG1054	Belongs to the UPF0176 family
GZ22_RS01610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZ22_RS01620	COG2084	Dehydrogenase
GZ22_RS01625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZ22_RS01635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GZ22_RS01645	COG0463	Glycosyl transferase, family 2
GZ22_RS01655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZ22_RS01660	COG0745	RESPONSE REGULATOR receiver
GZ22_RS01665	COG3850	Histidine kinase
GZ22_RS01665	COG5002	protein histidine kinase activity
GZ22_RS01670	COG1217	gtp-binding protein TYPA
GZ22_RS01685	COG0577	efflux transmembrane transporter activity
GZ22_RS01690	COG1136	(ABC) transporter
GZ22_RS01695	COG0018	arginyl-trna synthetase
GZ22_RS01710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZ22_RS01715	COG1914	H( )-stimulated, divalent metal cation uptake system
GZ22_RS01720	COG1597	lipid kinase activity
GZ22_RS01725	COG0488	(ABC) transporter
GZ22_RS01730	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS01745	COG0596	Alpha beta hydrolase
GZ22_RS01750	COG0513	Belongs to the DEAD box helicase family
GZ22_RS01755	COG3402	PFAM membrane-flanked domain
GZ22_RS01760	COG3428	Bacterial PH domain
GZ22_RS01765	COG0705	Rhomboid family
GZ22_RS01770	COG0736	holo-[acyl-carrier-protein] synthase activity
GZ22_RS01775	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GZ22_RS01775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GZ22_RS01780	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GZ22_RS01785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GZ22_RS01790	COG0864	Transcriptional regulator
GZ22_RS01795	COG2337	Toxic component of a toxin-antitoxin (TA) module
GZ22_RS01800	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS01805	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS01810	COG2172	sigma factor antagonist activity
GZ22_RS01815	COG2208	phosphoserine phosphatase activity
GZ22_RS01820	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS01825	COG2172	sigma factor antagonist activity
GZ22_RS01830	COG1191	sigma factor activity
GZ22_RS01835	COG2208	phosphoserine phosphatase activity
GZ22_RS01840	COG2183	response to ionizing radiation
GZ22_RS01845	COG3091	SprT-like family
GZ22_RS01935	COG0802	atpase or kinase
GZ22_RS01940	COG1214	PFAM Peptidase M22, glycoprotease
GZ22_RS01945	COG0456	acetyltransferase
GZ22_RS01950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GZ22_RS01955	COG0488	(ABC) transporter
GZ22_RS01960	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GZ22_RS01965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZ22_RS01970	COG0390	transport system, permease component
GZ22_RS01980	COG0589	response to stress
GZ22_RS01985	COG2814	Major facilitator Superfamily
GZ22_RS02000	COG1733	regulation of RNA biosynthetic process
GZ22_RS02010	COG0583	DNA-binding transcription factor activity
GZ22_RS02015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZ22_RS02030	COG1609	Transcriptional regulator
GZ22_RS02035	COG1811	Na channel or pump
GZ22_RS02050	COG0789	Transcriptional regulator
GZ22_RS02065	COG1620	l-lactate permease
GZ22_RS02070	COG0039	L-malate dehydrogenase activity
GZ22_RS02075	COG2368	4-hydroxyphenylacetate
GZ22_RS02090	COG1396	sequence-specific DNA binding
GZ22_RS02100	COG1476	TRANSCRIPTIONal
GZ22_RS02110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GZ22_RS02115	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZ22_RS02115	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZ22_RS02120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZ22_RS02120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZ22_RS02140	COG0833	amino acid
GZ22_RS02145	COG1307	EDD domain protein, DegV family
GZ22_RS02175	COG1115	amino acid carrier protein
GZ22_RS02215	COG0456	acetyltransferase
GZ22_RS02225	COG1266	CAAX protease self-immunity
GZ22_RS02230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GZ22_RS02235	COG0459	protein refolding
GZ22_RS02245	COG2268	Band 7 protein
GZ22_RS02250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GZ22_RS02260	COG4336	lyase activity
GZ22_RS02285	COG2807	transmembrane transport
GZ22_RS02295	COG1486	melibiose metabolic process
GZ22_RS02300	COG1653	transport
GZ22_RS02305	COG1175	transmembrane transport
GZ22_RS02310	COG0395	ABC-type sugar transport system, permease component
GZ22_RS02315	COG3708	Transcriptional regulator
GZ22_RS02315	COG2207	Transcriptional regulator
GZ22_RS02325	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GZ22_RS02330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZ22_RS02340	COG0745	RESPONSE REGULATOR receiver
GZ22_RS02345	COG2814	Major facilitator Superfamily
GZ22_RS02355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_RS02365	COG0431	NADPH-dependent FMN reductase
GZ22_RS02370	COG0730	response to heat
GZ22_RS02375	COG1335	isochorismatase
GZ22_RS02395	COG3959	Transketolase, thiamine diphosphate binding domain
GZ22_RS02400	COG3958	Transketolase
GZ22_RS02405	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS02415	COG2186	Transcriptional regulator
GZ22_RS02425	COG1116	anion transmembrane transporter activity
GZ22_RS02435	COG1263	PTS System
GZ22_RS02435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_RS02435	COG2190	(PTS) system
GZ22_RS02440	COG2723	6-phospho-beta-galactosidase activity
GZ22_RS02455	COG0693	protein deglycase activity
GZ22_RS02460	COG1473	amidohydrolase
GZ22_RS02475	COG1069	ribulokinase activity
GZ22_RS02485	COG1011	Hydrolase
GZ22_RS02500	COG1609	Transcriptional regulator
GZ22_RS02505	COG1653	transport
GZ22_RS02515	COG1175	transmembrane transport
GZ22_RS02520	COG0395	ABC-type sugar transport system, permease component
GZ22_RS02530	COG3534	alpha-L-arabinofuranosidase
GZ22_RS02535	COG0371	Dehydrogenase
GZ22_RS02540	COG0647	UMP catabolic process
GZ22_RS02545	COG3940	Belongs to the glycosyl hydrolase 43 family
GZ22_RS02595	COG1280	lysine exporter protein (LysE YggA)
GZ22_RS02615	COG1733	regulation of RNA biosynthetic process
GZ22_RS02620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_RS02625	COG0431	NADPH-dependent FMN reductase
GZ22_RS02650	COG1113	amino acid transport
GZ22_RS02655	COG1113	amino acid transport
GZ22_RS02670	COG3290	protein histidine kinase activity
GZ22_RS02675	COG4565	transcriptional regulatory protein
GZ22_RS02680	COG2851	Citrate transporter
GZ22_RS02685	COG0693	protein deglycase activity
GZ22_RS02690	COG2910	NAD(P)H-binding
GZ22_RS02695	COG1959	2 iron, 2 sulfur cluster binding
GZ22_RS02705	COG1959	2 iron, 2 sulfur cluster binding
GZ22_RS02715	COG5002	protein histidine kinase activity
GZ22_RS02720	COG0745	RESPONSE REGULATOR receiver
GZ22_RS02730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GZ22_RS02735	COG1696	Membrane protein involved in D-alanine export
GZ22_RS02740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZ22_RS02745	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GZ22_RS02755	COG2153	protein acetylation
GZ22_RS02760	COG2364	Membrane
GZ22_RS02765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZ22_RS02770	COG4989	oxidoreductase activity
GZ22_RS02780	COG2814	Major facilitator Superfamily
GZ22_RS02785	COG3402	PFAM membrane-flanked domain
GZ22_RS02820	COG0840	transmembrane signaling receptor activity
GZ22_RS02830	COG2247	cell wall binding repeat
GZ22_RS02830	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZ22_RS02835	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZ22_RS02850	COG0490	domain, Protein
GZ22_RS02855	COG0475	glutathione-regulated potassium exporter activity
GZ22_RS02860	COG0714	Associated with various cellular activities
GZ22_RS02870	COG1305	Transglutaminase-like
GZ22_RS02875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GZ22_RS02875	COG0519	Catalyzes the synthesis of GMP from XMP
GZ22_RS02880	COG4129	membrane
GZ22_RS02890	COG2252	PERMEase
GZ22_RS02900	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GZ22_RS02910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GZ22_RS02915	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GZ22_RS02920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GZ22_RS02925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GZ22_RS02930	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GZ22_RS02935	COG0047	phosphoribosylformylglycinamidine synthase activity
GZ22_RS02940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GZ22_RS02945	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GZ22_RS02950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GZ22_RS02955	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GZ22_RS02960	COG0138	bifunctional purine biosynthesis protein purh
GZ22_RS02965	COG0151	Belongs to the GarS family
GZ22_RS02975	COG4496	protein, YerC YecD
GZ22_RS02980	COG0673	inositol 2-dehydrogenase activity
GZ22_RS02985	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GZ22_RS02990	COG0210	DNA helicase
GZ22_RS02995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GZ22_RS03000	COG4851	CamS sex pheromone cAM373 precursor
GZ22_RS03010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZ22_RS03015	COG0154	amidase activity
GZ22_RS03020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZ22_RS03030	COG4122	O-methyltransferase activity
GZ22_RS03035	COG1597	lipid kinase activity
GZ22_RS03040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GZ22_RS03070	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GZ22_RS03075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZ22_RS03080	COG5658	integral membrane protein
GZ22_RS03090	COG0534	Mate efflux family protein
GZ22_RS03095	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GZ22_RS03100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GZ22_RS03110	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS03115	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GZ22_RS03120	COG0583	DNA-binding transcription factor activity
GZ22_RS03125	COG0114	fumarate hydratase activity
GZ22_RS03130	COG2188	Transcriptional regulator
GZ22_RS03140	COG2723	6-phospho-beta-galactosidase activity
GZ22_RS03165	COG3842	ATPase activity
GZ22_RS03185	COG0596	Alpha beta hydrolase
GZ22_RS03195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_RS03205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GZ22_RS03210	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GZ22_RS03215	COG0456	acetyltransferase
GZ22_RS03220	COG0505	Belongs to the CarA family
GZ22_RS03235	COG1757	Na H antiporter
GZ22_RS03240	COG1653	transport
GZ22_RS03245	COG1175	transmembrane transport
GZ22_RS03250	COG3833	ABC-type maltose transport systems, permease component
GZ22_RS03270	COG2226	methyltransferase
GZ22_RS03275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GZ22_RS03290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_RS03305	COG0840	transmembrane signaling receptor activity
GZ22_RS03310	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_RS03315	COG0662	Cupin 2, conserved barrel domain protein
GZ22_RS03320	COG3401	FG-GAP repeat protein
GZ22_RS03325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZ22_RS03360	COG3250	beta-galactosidase activity
GZ22_RS03375	COG1228	amidohydrolase
GZ22_RS03380	COG0471	metal ion transport
GZ22_RS03395	COG0598	Magnesium transport protein CorA
GZ22_RS03405	COG2188	Transcriptional regulator
GZ22_RS03410	COG1486	melibiose metabolic process
GZ22_RS03415	COG3394	polysaccharide catabolic process
GZ22_RS03420	COG1263	PTS System
GZ22_RS03420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_RS03445	COG1077	Cell shape determining protein MreB Mrl
GZ22_RS03450	COG2340	Cysteine-rich secretory protein family
GZ22_RS03465	COG1619	proteins homologs of microcin C7 resistance protein MccF
GZ22_RS03470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GZ22_RS03480	COG1295	ribonuclease BN
GZ22_RS03485	COG2217	Heavy metal translocating P-type atpase
GZ22_RS03490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZ22_RS03495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZ22_RS03500	COG0765	amino acid transport
GZ22_RS03505	COG0477	Major facilitator Superfamily
GZ22_RS03525	COG0583	DNA-binding transcription factor activity
GZ22_RS03530	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GZ22_RS03535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZ22_RS03540	COG0542	response to heat
GZ22_RS03550	COG1131	(ABC) transporter
GZ22_RS03555	COG1725	Transcriptional regulator
GZ22_RS03565	COG1442	glycosyl transferase family 8
GZ22_RS03570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_RS03595	COG1115	amino acid carrier protein
GZ22_RS03605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GZ22_RS03625	COG1335	isochorismatase
GZ22_RS03630	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GZ22_RS03635	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GZ22_RS03640	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GZ22_RS03660	COG1132	(ABC) transporter
GZ22_RS03670	COG1368	sulfuric ester hydrolase activity
GZ22_RS03680	COG1063	alcohol dehydrogenase
GZ22_RS03685	COG0628	permease
GZ22_RS03690	COG1090	epimerase
GZ22_RS03695	COG2137	regulation of response to DNA damage stimulus
GZ22_RS03710	COG1988	membrane-bound metal-dependent
GZ22_RS03715	COG1194	a g-specific adenine glycosylase
GZ22_RS03725	COG3557	Belongs to the UPF0374 family
GZ22_RS03730	COG1132	(ABC) transporter
GZ22_RS03735	COG4129	membrane
GZ22_RS03750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GZ22_RS03765	COG2096	Adenosyltransferase
GZ22_RS03770	COG0735	belongs to the Fur family
GZ22_RS03865	COG0745	RESPONSE REGULATOR receiver
GZ22_RS03870	COG2205	protein histidine kinase activity
GZ22_RS03875	COG1136	(ABC) transporter
GZ22_RS03880	COG0577	efflux transmembrane transporter activity
GZ22_RS03890	COG0604	alcohol dehydrogenase
GZ22_RS03895	COG1966	Carbon starvation protein
GZ22_RS03900	COG0667	Aldo Keto reductase
GZ22_RS03920	COG0737	Belongs to the 5'-nucleotidase family
GZ22_RS03935	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZ22_RS03950	COG3443	Belongs to the bacterial solute-binding protein 9 family
GZ22_RS03955	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZ22_RS03960	COG1121	(ABC) transporter
GZ22_RS03965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZ22_RS03980	COG2070	2-Nitropropane dioxygenase
GZ22_RS03985	COG1051	belongs to the nudix hydrolase family
GZ22_RS04010	COG4608	Belongs to the ABC transporter superfamily
GZ22_RS04015	COG0444	Belongs to the ABC transporter superfamily
GZ22_RS04030	COG0747	negative chemotaxis
GZ22_RS04035	COG1473	amidohydrolase
GZ22_RS04040	COG0626	cystathionine gamma-synthase activity
GZ22_RS04045	COG0626	cystathionine gamma-synthase activity
GZ22_RS04050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GZ22_RS04055	COG0110	maltose O-acetyltransferase activity
GZ22_RS04060	COG0697	spore germination
GZ22_RS04065	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_RS04070	COG1454	alcohol dehydrogenase
GZ22_RS04075	COG1253	flavin adenine dinucleotide binding
GZ22_RS04090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GZ22_RS04095	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_RS04110	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GZ22_RS04115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZ22_RS04130	COG0667	Aldo Keto reductase
GZ22_RS04135	COG2207	Transcriptional regulator
GZ22_RS04145	COG2409	Drug exporters of the RND superfamily
GZ22_RS04150	COG2357	RelA SpoT domain protein
GZ22_RS04155	COG1764	response to oxidative stress
GZ22_RS04160	COG1846	Transcriptional regulator
GZ22_RS04165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZ22_RS04185	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS04190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZ22_RS04195	COG0604	alcohol dehydrogenase
GZ22_RS04200	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS04210	COG0596	Alpha beta hydrolase
GZ22_RS04230	COG1271	oxidase subunit
GZ22_RS04235	COG1294	oxidase, subunit
GZ22_RS04240	COG4988	ABC transporter
GZ22_RS04245	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GZ22_RS04255	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS04265	COG0622	Phosphoesterase
GZ22_RS04275	COG0398	Pfam SNARE associated Golgi protein
GZ22_RS04280	COG0714	Associated with various cellular activities
GZ22_RS04305	COG0840	transmembrane signaling receptor activity
GZ22_RS04310	COG0778	Nitroreductase
GZ22_RS04335	COG2766	serine protein kinase
GZ22_RS04340	COG0730	response to heat
GZ22_RS04345	COG0583	DNA-binding transcription factor activity
GZ22_RS04350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GZ22_RS04355	COG0567	Dehydrogenase, E1 component
GZ22_RS04360	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZ22_RS04365	COG0697	spore germination
GZ22_RS04370	COG0531	amino acid
GZ22_RS04380	COG2718	Belongs to the UPF0229 family
GZ22_RS04385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GZ22_RS04390	COG0288	reversible hydration of carbon dioxide
GZ22_RS04395	COG1132	(ABC) transporter
GZ22_RS04400	COG1132	(ABC) transporter
GZ22_RS04405	COG1191	sigma factor activity
GZ22_RS04415	COG3153	acetyltransferase
GZ22_RS04415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZ22_RS04435	COG2226	methyltransferase
GZ22_RS04440	COG1854	S-ribosylhomocysteine lyase activity
GZ22_RS04445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZ22_RS04450	COG0626	cystathionine gamma-synthase activity
GZ22_RS04465	COG2719	SpoVR family
GZ22_RS04495	COG2226	methyltransferase
GZ22_RS04500	COG4990	cell redox homeostasis
GZ22_RS04505	COG3663	DNA glycosylase
GZ22_RS04510	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS04520	COG1131	(ABC) transporter
GZ22_RS04525	COG3223	Belongs to the PsiE family
GZ22_RS04530	COG0024	Methionine aminopeptidase
GZ22_RS04535	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GZ22_RS04545	COG2814	Major facilitator Superfamily
GZ22_RS04555	COG1876	peptidase activity
GZ22_RS04560	COG0114	fumarate hydratase activity
GZ22_RS04570	COG2508	Transcriptional regulator
GZ22_RS04580	COG3679	Belongs to the UPF0342 family
GZ22_RS04585	COG0420	3'-5' exonuclease activity
GZ22_RS04595	COG1510	regulation of RNA biosynthetic process
GZ22_RS04600	COG3481	metal-dependent phosphohydrolase, HD sub domain
GZ22_RS04615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZ22_RS04635	COG0517	IMP dehydrogenase activity
GZ22_RS04635	COG4175	Glycine betaine
GZ22_RS04645	COG2113	Glycine betaine
GZ22_RS04650	COG1510	regulation of RNA biosynthetic process
GZ22_RS04670	COG1595	DNA-templated transcription, initiation
GZ22_RS04690	COG4980	gas vesicle protein
GZ22_RS04695	COG0537	adenosine 5'-monophosphoramidase activity
GZ22_RS04700	COG1131	(ABC) transporter
GZ22_RS04705	COG4473	ABC transporter
GZ22_RS04715	COG1473	amidohydrolase
GZ22_RS04730	COG2329	Antibiotic biosynthesis monooxygenase
GZ22_RS04735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZ22_RS04740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GZ22_RS04745	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GZ22_RS04750	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GZ22_RS04760	COG1234	tRNA 3'-trailer cleavage
GZ22_RS04765	COG0095	Lipoate-protein ligase
GZ22_RS04770	COG0501	Belongs to the peptidase M48B family
GZ22_RS04775	COG4903	ComK protein
GZ22_RS04785	COG0398	Pfam SNARE associated Golgi protein
GZ22_RS04795	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GZ22_RS04800	COG1074	ATP-dependent DNA helicase activity
GZ22_RS04820	COG2311	Membrane
GZ22_RS04830	COG0367	asparagine synthase
GZ22_RS04835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZ22_RS04850	COG2203	Gaf domain
GZ22_RS04850	COG2199	diguanylate cyclase activity
GZ22_RS04855	COG0745	RESPONSE REGULATOR receiver
GZ22_RS04865	COG0561	phosphatase activity
GZ22_RS04870	COG1073	alpha beta
GZ22_RS04875	COG2151	metal-sulfur cluster biosynthetic enzyme
GZ22_RS04900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZ22_RS04910	COG0180	Tryptophanyl-tRNA synthetase
GZ22_RS04920	COG4166	transmembrane transport
GZ22_RS04925	COG0601	transmembrane transport
GZ22_RS04930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZ22_RS04935	COG0444	Belongs to the ABC transporter superfamily
GZ22_RS04940	COG4608	Belongs to the ABC transporter superfamily
GZ22_RS04950	COG0456	acetyltransferase
GZ22_RS04955	COG1393	Belongs to the ArsC family
GZ22_RS04960	COG4862	establishment of competence for transformation
GZ22_RS04970	COG1164	Oligoendopeptidase f
GZ22_RS04985	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GZ22_RS04990	COG2346	COG2346, Truncated hemoglobins
GZ22_RS04995	COG4116	CYTH
GZ22_RS05000	COG2357	RelA SpoT domain protein
GZ22_RS05005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GZ22_RS05010	COG0564	pseudouridine synthase activity
GZ22_RS05015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GZ22_RS05020	COG0772	Belongs to the SEDS family
GZ22_RS05025	COG2239	Acts as a magnesium transporter
GZ22_RS05050	COG2323	membrane
GZ22_RS05055	COG2153	protein acetylation
GZ22_RS05060	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GZ22_RS05065	COG2382	esterase
GZ22_RS05070	COG0346	lactoylglutathione lyase activity
GZ22_RS05075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZ22_RS05080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZ22_RS05080	COG1321	iron dependent repressor
GZ22_RS05085	COG1121	(ABC) transporter
GZ22_RS05090	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZ22_RS05100	COG0346	lactoylglutathione lyase activity
GZ22_RS05115	COG1215	transferase activity, transferring glycosyl groups
GZ22_RS05120	COG1278	Cold shock
GZ22_RS05130	COG2814	Major facilitator Superfamily
GZ22_RS05135	COG1309	transcriptional regulator
GZ22_RS05165	COG1113	amino acid transport
GZ22_RS05170	COG1846	Transcriptional regulator
GZ22_RS05175	COG0456	acetyltransferase
GZ22_RS05185	COG0561	phosphatase activity
GZ22_RS05190	COG0346	lactoylglutathione lyase activity
GZ22_RS05195	COG0110	maltose O-acetyltransferase activity
GZ22_RS05210	COG1733	regulation of RNA biosynthetic process
GZ22_RS05220	COG0667	Aldo Keto reductase
GZ22_RS05225	COG1960	acyl-CoA dehydrogenase activity
GZ22_RS05235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZ22_RS05240	COG2011	ABC-type metal ion transport system permease component
GZ22_RS05245	COG1464	Belongs to the NlpA lipoprotein family
GZ22_RS05250	COG4585	Histidine kinase
GZ22_RS05255	COG2197	response regulator
GZ22_RS05260	COG2409	Drug exporters of the RND superfamily
GZ22_RS05270	COG0584	glycerophosphoryl diester phosphodiesterase
GZ22_RS05280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZ22_RS05305	COG2828	Protein conserved in bacteria
GZ22_RS05310	COG0583	DNA-binding transcription factor activity
GZ22_RS05315	COG2851	Citrate transporter
GZ22_RS05320	COG4753	response regulator
GZ22_RS05320	COG2207	Transcriptional regulator
GZ22_RS05325	COG2972	Histidine kinase
GZ22_RS05345	COG3250	beta-galactosidase activity
GZ22_RS05385	COG3883	PFAM NLP P60 protein
GZ22_RS05385	COG0791	NLP P60 protein
GZ22_RS05395	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GZ22_RS05405	COG1176	ABC-type spermidine putrescine transport system, permease component I
GZ22_RS05410	COG3842	ATPase activity
GZ22_RS05430	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS05435	COG1846	Transcriptional regulator
GZ22_RS05440	COG0778	Nitroreductase
GZ22_RS05450	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GZ22_RS05455	COG2076	Multidrug Resistance protein
GZ22_RS05460	COG2076	Multidrug Resistance protein
GZ22_RS05530	COG1397	ADP-ribosylglycohydrolase
GZ22_RS05550	COG2135	peptidase activity
GZ22_RS05555	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GZ22_RS05560	COG1122	ATPase activity
GZ22_RS05565	COG4721	ABC-type cobalt transport system, permease component
GZ22_RS05575	COG0598	Magnesium transport protein CorA
GZ22_RS05585	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS05585	COG2202	Pas domain
GZ22_RS05605	COG1714	RDD family
GZ22_RS05620	COG1597	lipid kinase activity
GZ22_RS05625	COG1316	TRANSCRIPTIONal
GZ22_RS05640	COG0515	serine threonine protein kinase
GZ22_RS05655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GZ22_RS05660	COG0066	3-isopropylmalate dehydratase activity
GZ22_RS05665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GZ22_RS05670	COG0473	3-isopropylmalate dehydrogenase activity
GZ22_RS05675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZ22_RS05680	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GZ22_RS05685	COG0440	acetolactate synthase activity
GZ22_RS05690	COG0028	Belongs to the TPP enzyme family
GZ22_RS05695	COG0129	dihydroxy-acid dehydratase activity
GZ22_RS05715	COG0842	Transport permease protein
GZ22_RS05720	COG4585	Histidine kinase
GZ22_RS05725	COG2197	response regulator
GZ22_RS05730	COG3104	oligopeptide transport
GZ22_RS05735	COG3859	Proton-coupled thiamine transporter YuaJ
GZ22_RS05755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZ22_RS05765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZ22_RS05775	COG0436	Aminotransferase
GZ22_RS05790	COG1408	metallophosphoesterase
GZ22_RS05795	COG1272	protein, Hemolysin III
GZ22_RS05800	COG0517	IMP dehydrogenase activity
GZ22_RS05805	COG2171	N-acyltransferase activity
GZ22_RS05810	COG1473	amidohydrolase
GZ22_RS05815	COG0668	transmembrane transport
GZ22_RS05820	COG0450	alkyl hydroperoxide reductase
GZ22_RS05830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GZ22_RS05835	COG1132	(ABC) transporter
GZ22_RS05840	COG1132	(ABC) transporter
GZ22_RS05845	COG1271	oxidase subunit
GZ22_RS05850	COG1294	oxidase, subunit
GZ22_RS05855	COG0569	domain protein
GZ22_RS05860	COG0028	Belongs to the TPP enzyme family
GZ22_RS05865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GZ22_RS05870	COG5503	Protein of unknown function (DUF1447)
GZ22_RS05875	COG0561	phosphatase activity
GZ22_RS05880	COG0242	peptide deformylase activity
GZ22_RS05885	COG0497	DNA recombination
GZ22_RS05895	COG0022	dehydrogenase e1 component
GZ22_RS05900	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZ22_RS05915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GZ22_RS05920	COG0726	polysaccharide deacetylase
GZ22_RS05925	COG1982	Orn Lys Arg decarboxylase major
GZ22_RS05930	COG4476	Belongs to the UPF0223 family
GZ22_RS05935	COG4493	Belongs to the UPF0637 family
GZ22_RS05945	COG0483	inositol monophosphate 1-phosphatase activity
GZ22_RS05955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GZ22_RS05960	COG4838	Belongs to the UPF0358 family
GZ22_RS05965	COG0772	Belongs to the SEDS family
GZ22_RS05970	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GZ22_RS05975	COG1612	heme a metabolic process
GZ22_RS05990	COG2340	Cysteine-rich secretory protein family
GZ22_RS06005	COG3679	Belongs to the UPF0342 family
GZ22_RS06010	COG4471	UPF0298 protein
GZ22_RS06015	COG0742	ribosomal rna small subunit methyltransferase
GZ22_RS06020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GZ22_RS06025	COG3314	Sporulation integral membrane protein YlbJ
GZ22_RS06030	COG3480	Lon protease (S16) C-terminal proteolytic domain
GZ22_RS06035	COG1323	Belongs to the UPF0348 family
GZ22_RS06040	COG1399	metal-binding, possibly nucleic acid-binding protein
GZ22_RS06055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GZ22_RS06065	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GZ22_RS06070	COG2001	Belongs to the MraZ family
GZ22_RS06075	COG0275	rRNA processing
GZ22_RS06080	COG4839	cell division protein FtsL
GZ22_RS06085	COG0768	penicillin binding
GZ22_RS06090	COG0768	penicillin binding
GZ22_RS06100	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GZ22_RS06105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GZ22_RS06110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GZ22_RS06115	COG0772	Belongs to the SEDS family
GZ22_RS06120	COG0431	NADPH-dependent FMN reductase
GZ22_RS06125	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GZ22_RS06130	COG0849	cell division
GZ22_RS06135	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GZ22_RS06145	COG1191	sigma factor activity
GZ22_RS06150	COG1191	sigma factor activity
GZ22_RS06155	COG1873	PFAM PRC-barrel domain
GZ22_RS06165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GZ22_RS06170	COG1799	cell septum assembly
GZ22_RS06175	COG0762	integral membrane protein
GZ22_RS06180	COG2302	S4 RNA-binding domain
GZ22_RS06185	COG3599	regulation of cell shape
GZ22_RS06190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GZ22_RS06195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GZ22_RS06200	COG0564	pseudouridine synthase activity
GZ22_RS06205	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GZ22_RS06215	COG0540	Belongs to the ATCase OTCase family
GZ22_RS06220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GZ22_RS06225	COG0505	Belongs to the CarA family
GZ22_RS06235	COG0543	2 iron, 2 sulfur cluster binding
GZ22_RS06240	COG0167	dihydroorotate dehydrogenase activity
GZ22_RS06245	COG0284	orotidine-5'-phosphate decarboxylase activity
GZ22_RS06250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GZ22_RS06260	COG0028	Belongs to the TPP enzyme family
GZ22_RS06285	COG1266	CAAX protease self-immunity
GZ22_RS06290	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GZ22_RS06295	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GZ22_RS06300	COG1561	YicC-like family, N-terminal region
GZ22_RS06305	COG2052	Domain of unknown function (DUF370)
GZ22_RS06310	COG0194	GDP metabolic process
GZ22_RS06315	COG1758	RNA polymerase activity
GZ22_RS06320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GZ22_RS06325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GZ22_RS06330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GZ22_RS06335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GZ22_RS06335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GZ22_RS06340	COG0631	protein serine/threonine phosphatase activity
GZ22_RS06345	COG2815	serine threonine protein kinase
GZ22_RS06345	COG0515	serine threonine protein kinase
GZ22_RS06350	COG1162	GTPase activity
GZ22_RS06355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GZ22_RS06360	COG1564	THIamine pyrophosphokinase
GZ22_RS06365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GZ22_RS06370	COG1302	Protein conserved in bacteria
GZ22_RS06375	COG1461	Dihydroxyacetone kinase
GZ22_RS06380	COG1760	l-serine dehydratase
GZ22_RS06385	COG1760	l-serine dehydratase
GZ22_RS06390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GZ22_RS06400	COG0416	fatty acid biosynthetic process
GZ22_RS06405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GZ22_RS06410	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS06415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZ22_RS06420	COG0571	ribonuclease III activity
GZ22_RS06425	COG4840	Belongs to the UPF0435 family
GZ22_RS06430	COG1196	nuclear chromosome segregation
GZ22_RS06435	COG0552	protein localization to endoplasmic reticulum
GZ22_RS06440	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GZ22_RS06445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GZ22_RS06450	COG0228	four-way junction DNA binding
GZ22_RS06455	COG1837	Belongs to the UPF0109 family
GZ22_RS06465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GZ22_RS06470	COG0336	Belongs to the RNA methyltransferase TrmD family
GZ22_RS06475	COG0335	large ribosomal subunit rRNA binding
GZ22_RS06485	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GZ22_RS06490	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GZ22_RS06500	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GZ22_RS06505	COG0045	succinate-CoA ligase (ADP-forming) activity
GZ22_RS06510	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GZ22_RS06515	COG0758	DNA mediated transformation
GZ22_RS06520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZ22_RS06525	COG4974	Belongs to the 'phage' integrase family
GZ22_RS06530	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GZ22_RS06535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GZ22_RS06540	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GZ22_RS06545	COG1815	bacterial-type flagellum-dependent cell motility
GZ22_RS06550	COG1558	bacterial-type flagellum-dependent cell motility
GZ22_RS06555	COG1677	Flagellar hook-basal body complex protein FliE
GZ22_RS06560	COG1766	The M ring may be actively involved in energy transduction
GZ22_RS06565	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GZ22_RS06570	COG1317	bacterial-type flagellum organization
GZ22_RS06575	COG1157	protein secretion by the type III secretion system
GZ22_RS06580	COG2882	bacterial-type flagellum organization
GZ22_RS06595	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GZ22_RS06600	COG4786	Flagellar basal body rod
GZ22_RS06605	COG1582	Flagellar protein (FlbD)
GZ22_RS06615	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GZ22_RS06620	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GZ22_RS06620	COG1776	CheC inhibitor of MCP methylation
GZ22_RS06625	COG2201	protein-glutamate methylesterase activity
GZ22_RS06630	COG3190	flagellar
GZ22_RS06635	COG1338	Plays a role in the flagellum-specific transport system
GZ22_RS06640	COG1987	bacterial-type flagellum assembly
GZ22_RS06645	COG1684	flagellar biosynthetic protein fliR
GZ22_RS06650	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GZ22_RS06655	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GZ22_RS06660	COG1419	protein localization to endoplasmic reticulum
GZ22_RS06665	COG0455	bacterial-type flagellum organization
GZ22_RS06670	COG2201	protein-glutamate methylesterase activity
GZ22_RS06675	COG2198	Histidine kinase
GZ22_RS06675	COG0643	Histidine kinase
GZ22_RS06680	COG0835	chemotaxis
GZ22_RS06685	COG1776	CheC inhibitor of MCP methylation
GZ22_RS06690	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GZ22_RS06695	COG1191	sigma factor activity
GZ22_RS06705	COG0052	Belongs to the universal ribosomal protein uS2 family
GZ22_RS06710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GZ22_RS06715	COG0528	UMP kinase activity
GZ22_RS06720	COG0233	cytoplasmic translational termination
GZ22_RS06725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GZ22_RS06730	COG4589	Belongs to the CDS family
GZ22_RS06740	COG0750	zinc metalloprotease
GZ22_RS06745	COG0442	prolyl-tRNA aminoacylation
GZ22_RS06750	COG2176	DNA-directed DNA polymerase activity
GZ22_RS06755	COG0779	Required for maturation of 30S ribosomal subunits
GZ22_RS06760	COG0195	Participates in both transcription termination and antitermination
GZ22_RS06765	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GZ22_RS06770	COG1358	cellular component organization or biogenesis
GZ22_RS06775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GZ22_RS06780	COG1550	Protein conserved in bacteria
GZ22_RS06785	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GZ22_RS06790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GZ22_RS06795	COG0196	riboflavin kinase activity
GZ22_RS06800	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GZ22_RS06805	COG1185	polyribonucleotide nucleotidyltransferase activity
GZ22_RS06810	COG0726	polysaccharide deacetylase
GZ22_RS06815	COG0612	Peptidase, M16
GZ22_RS06820	COG1873	PFAM PRC-barrel domain
GZ22_RS06825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZ22_RS06830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GZ22_RS06835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GZ22_RS06840	COG0527	aspartate kinase activity
GZ22_RS06845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZ22_RS06850	COG0740	serine-type endopeptidase activity
GZ22_RS06860	COG1674	ftsk spoiiie
GZ22_RS06865	COG1744	ABC transporter substrate-binding protein PnrA-like
GZ22_RS06870	COG3845	ABC transporter
GZ22_RS06875	COG4603	Belongs to the binding-protein-dependent transport system permease family
GZ22_RS06880	COG1079	Belongs to the binding-protein-dependent transport system permease family
GZ22_RS06885	COG0612	Peptidase, M16
GZ22_RS06890	COG0612	Peptidase, M16
GZ22_RS06895	COG0300	oxidoreductase activity
GZ22_RS06910	COG1426	Protein conserved in bacteria
GZ22_RS06915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GZ22_RS06920	COG1058	Belongs to the CinA family
GZ22_RS06920	COG1546	Belongs to the CinA family
GZ22_RS06925	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GZ22_RS06930	COG1418	mRNA catabolic process
GZ22_RS06935	COG1692	metallophosphoesterase
GZ22_RS06940	COG2359	stage V sporulation protein S
GZ22_RS06945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZ22_RS06950	COG4550	Control of competence regulator ComK, YlbF/YmcA
GZ22_RS06960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GZ22_RS06965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GZ22_RS06975	COG0783	Belongs to the Dps family
GZ22_RS06980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GZ22_RS06985	COG1923	regulation of RNA biosynthetic process
GZ22_RS06990	COG0464	growth
GZ22_RS06995	COG0697	spore germination
GZ22_RS07000	COG0531	amino acid
GZ22_RS07010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GZ22_RS07015	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GZ22_RS07020	COG0789	Transcriptional regulator
GZ22_RS07025	COG0174	glutamine synthetase
GZ22_RS07050	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS07065	COG0628	permease
GZ22_RS07070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GZ22_RS07075	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GZ22_RS07080	COG4224	UPF0291 protein
GZ22_RS07095	COG3763	UPF0154 protein
GZ22_RS07105	COG1971	Probably functions as a manganese efflux pump
GZ22_RS07120	COG0785	Cytochrome C biogenesis protein
GZ22_RS07125	COG2111	Na H antiporter
GZ22_RS07130	COG2201	protein-glutamate methylesterase activity
GZ22_RS07135	COG4846	Membrane protein involved in cytochrome C biogenesis
GZ22_RS07140	COG4191	Histidine kinase
GZ22_RS07145	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GZ22_RS07155	COG0464	growth
GZ22_RS07160	COG0824	Thioesterase
GZ22_RS07170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GZ22_RS07175	COG1469	GTP cyclohydrolase I activity
GZ22_RS07180	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GZ22_RS07185	COG1125	glycine betaine transport
GZ22_RS07185	COG0517	IMP dehydrogenase activity
GZ22_RS07190	COG1174	glycine betaine transport
GZ22_RS07195	COG1832	CoA-binding protein
GZ22_RS07200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GZ22_RS07205	COG0187	DNA topoisomerase II activity
GZ22_RS07210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GZ22_RS07220	COG0745	RESPONSE REGULATOR receiver
GZ22_RS07225	COG3850	Histidine kinase
GZ22_RS07225	COG5002	protein histidine kinase activity
GZ22_RS07250	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GZ22_RS07255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZ22_RS07255	COG0723	plastoquinol--plastocyanin reductase activity
GZ22_RS07275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZ22_RS07280	COG0583	DNA-binding transcription factor activity
GZ22_RS07285	COG2814	Major facilitator Superfamily
GZ22_RS07295	COG1309	transcriptional regulator
GZ22_RS07300	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GZ22_RS07305	COG0656	L-ascorbic acid biosynthetic process
GZ22_RS07315	COG0656	L-ascorbic acid biosynthetic process
GZ22_RS07325	COG2076	Multidrug Resistance protein
GZ22_RS07330	COG2076	Multidrug Resistance protein
GZ22_RS07335	COG0753	catalase activity
GZ22_RS07340	COG2223	nitrite transmembrane transporter activity
GZ22_RS07360	COG1846	Transcriptional regulator
GZ22_RS07360	COG0456	acetyltransferase
GZ22_RS07370	COG0840	transmembrane signaling receptor activity
GZ22_RS07375	COG0840	transmembrane signaling receptor activity
GZ22_RS07380	COG1063	alcohol dehydrogenase
GZ22_RS07390	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS07395	COG0110	maltose O-acetyltransferase activity
GZ22_RS07410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GZ22_RS07420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GZ22_RS07425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GZ22_RS07430	COG0131	Imidazoleglycerol-phosphate dehydratase
GZ22_RS07440	COG0107	imidazoleglycerol-phosphate synthase activity
GZ22_RS07455	COG0626	cystathionine gamma-synthase activity
GZ22_RS07480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_RS07485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZ22_RS07490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZ22_RS07495	COG0583	DNA-binding transcription factor activity
GZ22_RS07500	COG0067	glutamate synthase
GZ22_RS07500	COG0070	glutamate synthase
GZ22_RS07500	COG0069	glutamate synthase activity
GZ22_RS07505	COG0493	'glutamate synthase
GZ22_RS07510	COG0840	transmembrane signaling receptor activity
GZ22_RS07520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GZ22_RS07530	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS07535	COG1657	PFAM Prenyltransferase squalene oxidase
GZ22_RS07540	COG3321	synthase
GZ22_RS07540	COG0604	alcohol dehydrogenase
GZ22_RS07540	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS07545	COG0708	Exodeoxyribonuclease III
GZ22_RS07550	COG2027	D-alanyl-D-alanine carboxypeptidase
GZ22_RS07570	COG0346	lactoylglutathione lyase activity
GZ22_RS07575	COG0516	GMP reductase activity
GZ22_RS07575	COG0517	IMP dehydrogenase activity
GZ22_RS07595	COG1472	Belongs to the glycosyl hydrolase 3 family
GZ22_RS07600	COG1114	Component of the transport system for branched-chain amino acids
GZ22_RS07605	COG2404	hydrolase activity, acting on ester bonds
GZ22_RS07610	COG2244	polysaccharide biosynthetic process
GZ22_RS07630	COG1473	amidohydrolase
GZ22_RS07635	COG0488	(ABC) transporter
GZ22_RS07640	COG1472	Belongs to the glycosyl hydrolase 3 family
GZ22_RS07645	COG3876	Protein conserved in bacteria
GZ22_RS07650	COG0583	DNA-binding transcription factor activity
GZ22_RS07655	COG0604	alcohol dehydrogenase
GZ22_RS07655	COG3321	synthase
GZ22_RS07655	COG4221	oxidoreductase activity
GZ22_RS07655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GZ22_RS07660	COG0438	transferase activity, transferring glycosyl groups
GZ22_RS07670	COG0723	plastoquinol--plastocyanin reductase activity
GZ22_RS07670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZ22_RS07675	COG1254	Belongs to the acylphosphatase family
GZ22_RS07680	COG0723	plastoquinol--plastocyanin reductase activity
GZ22_RS07680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZ22_RS07705	COG3180	Ammonia monooxygenase
GZ22_RS07710	COG0861	Integral membrane protein TerC family
GZ22_RS07715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZ22_RS07715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZ22_RS07730	COG0419	ATPase involved in DNA repair
GZ22_RS07735	COG0420	3'-5' exonuclease activity
GZ22_RS07740	COG3403	YqcI/YcgG family
GZ22_RS07760	COG1368	sulfuric ester hydrolase activity
GZ22_RS07770	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GZ22_RS07775	COG4479	Belongs to the UPF0346 family
GZ22_RS07790	COG1418	mRNA catabolic process
GZ22_RS07795	COG1801	Protein of unknown function DUF72
GZ22_RS07805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GZ22_RS07810	COG0328	RNA-DNA hybrid ribonuclease activity
GZ22_RS07825	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GZ22_RS07830	COG0116	Belongs to the methyltransferase superfamily
GZ22_RS07840	COG4474	Belongs to the UPF0398 family
GZ22_RS07850	COG1304	FMN binding
GZ22_RS07875	COG1562	ergosterol biosynthetic process
GZ22_RS07890	COG0295	cytidine deaminase activity
GZ22_RS07910	COG3331	DNA recombination
GZ22_RS07915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZ22_RS07915	COG4499	WXG100 protein secretion system (Wss), protein YukC
GZ22_RS07920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GZ22_RS07925	COG3935	DnaD domain protein
GZ22_RS07930	COG0017	Asparaginyl-tRNA synthetase
GZ22_RS07940	COG1199	ATP-dependent helicase activity
GZ22_RS07940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GZ22_RS07945	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GZ22_RS07950	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GZ22_RS07965	COG0617	tRNA 3'-terminal CCA addition
GZ22_RS07970	COG0438	transferase activity, transferring glycosyl groups
GZ22_RS07975	COG1803	Methylglyoxal synthase
GZ22_RS07980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GZ22_RS07985	COG1694	Mazg nucleotide pyrophosphohydrolase
GZ22_RS07990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZ22_RS07995	COG0693	protein deglycase activity
GZ22_RS08000	COG2738	Putative neutral zinc metallopeptidase
GZ22_RS08010	COG4347	Protein of unknown function (DUF1405)
GZ22_RS08020	COG0457	Tetratricopeptide repeat
GZ22_RS08025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GZ22_RS08030	COG0287	Prephenate dehydrogenase
GZ22_RS08040	COG4401	Chorismate mutase type I
GZ22_RS08045	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GZ22_RS08050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GZ22_RS08065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GZ22_RS08070	COG0105	UTP biosynthetic process
GZ22_RS08075	COG0142	geranyltranstransferase activity
GZ22_RS08080	COG2226	methyltransferase
GZ22_RS08090	COG0776	regulation of translation
GZ22_RS08095	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GZ22_RS08105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GZ22_RS08110	COG1160	GTP binding
GZ22_RS08120	COG0539	negative regulation of cytoplasmic translation
GZ22_RS08130	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GZ22_RS08140	COG2959	enzyme of heme biosynthesis
GZ22_RS08145	COG3409	Peptidoglycan-binding domain 1 protein
GZ22_RS08145	COG3773	Cell wall hydrolase
GZ22_RS08150	COG2339	peptidase activity
GZ22_RS08160	COG0492	ferredoxin-NADP+ reductase activity
GZ22_RS08165	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GZ22_RS08170	COG4862	establishment of competence for transformation
GZ22_RS08180	COG0514	ATP-dependent DNA helicase (RecQ)
GZ22_RS08190	COG1141	Ferredoxin
GZ22_RS08205	COG5002	protein histidine kinase activity
GZ22_RS08210	COG0745	RESPONSE REGULATOR receiver
GZ22_RS08215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GZ22_RS08220	COG1333	cytochrome c biogenesis protein
GZ22_RS08225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZ22_RS08230	COG1187	pseudouridine synthase activity
GZ22_RS08235	COG0700	Nucleoside recognition
GZ22_RS08240	COG2715	membrane protein required for spore maturation
GZ22_RS08245	COG1686	Belongs to the peptidase S11 family
GZ22_RS08250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GZ22_RS08255	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GZ22_RS08260	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GZ22_RS08275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GZ22_RS08280	COG0019	diaminopimelate decarboxylase activity
GZ22_RS08285	COG0697	spore germination
GZ22_RS08300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZ22_RS08325	COG2172	sigma factor antagonist activity
GZ22_RS08335	COG1686	Belongs to the peptidase S11 family
GZ22_RS08350	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GZ22_RS08355	COG4974	Belongs to the 'phage' integrase family
GZ22_RS08365	COG0735	belongs to the Fur family
GZ22_RS08370	COG1300	Membrane
GZ22_RS08375	COG0494	nUDIX hydrolase
GZ22_RS08380	COG0667	Aldo Keto reductase
GZ22_RS08390	COG0300	oxidoreductase activity
GZ22_RS08395	COG4187	Peptidase family M20/M25/M40
GZ22_RS08400	COG0584	glycerophosphoryl diester phosphodiesterase
GZ22_RS08405	COG1902	pentaerythritol trinitrate reductase activity
GZ22_RS08410	COG1234	tRNA 3'-trailer cleavage
GZ22_RS08415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZ22_RS08420	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZ22_RS08425	COG1376	ErfK ybiS ycfS ynhG family protein
GZ22_RS08430	COG4129	membrane
GZ22_RS08440	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZ22_RS08445	COG0022	dehydrogenase e1 component
GZ22_RS08450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GZ22_RS08455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZ22_RS08470	COG0280	phosphate acetyltransferase
GZ22_RS08475	COG3290	protein histidine kinase activity
GZ22_RS08475	COG3829	transcription factor binding
GZ22_RS08480	COG0527	aspartate kinase activity
GZ22_RS08485	COG2160	L-arabinose isomerase activity
GZ22_RS08495	COG1879	ABC-type sugar transport system periplasmic component
GZ22_RS08500	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZ22_RS08505	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZ22_RS08510	COG1129	ABC transporter
GZ22_RS08515	COG2207	Transcriptional regulator
GZ22_RS08515	COG4753	response regulator
GZ22_RS08520	COG2972	Histidine kinase
GZ22_RS08530	COG1349	DNA-binding transcription factor activity
GZ22_RS08535	COG4806	L-rhamnose isomerase
GZ22_RS08540	COG3254	rhamnose metabolic process
GZ22_RS08545	COG1070	Carbohydrate kinase
GZ22_RS08550	COG3347	Dehydrogenase
GZ22_RS08550	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS08555	COG2814	Major facilitator Superfamily
GZ22_RS08570	COG0750	zinc metalloprotease
GZ22_RS08575	COG0497	DNA recombination
GZ22_RS08580	COG1438	arginine binding
GZ22_RS08585	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GZ22_RS08590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GZ22_RS08595	COG0142	geranyltranstransferase activity
GZ22_RS08600	COG1722	exodeoxyribonuclease VII activity
GZ22_RS08605	COG1570	exodeoxyribonuclease VII activity
GZ22_RS08610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GZ22_RS08615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GZ22_RS08620	COG1302	Protein conserved in bacteria
GZ22_RS08625	COG0439	Biotin carboxylase
GZ22_RS08630	COG0511	ligase activity, forming carbon-carbon bonds
GZ22_RS08635	COG1132	(ABC) transporter
GZ22_RS08640	COG1132	(ABC) transporter
GZ22_RS08680	COG3854	ATPases associated with a variety of cellular activities
GZ22_RS08685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GZ22_RS08690	COG0006	proline dipeptidase activity
GZ22_RS08705	COG3872	metal-dependent enzyme
GZ22_RS08715	COG1752	Esterase of the alpha-beta hydrolase superfamily
GZ22_RS08720	COG1321	iron dependent repressor
GZ22_RS08725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZ22_RS08730	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GZ22_RS08735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GZ22_RS08740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GZ22_RS08745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZ22_RS08755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GZ22_RS08760	COG1459	type II secretion system
GZ22_RS08765	COG4537	Required for transformation and DNA binding
GZ22_RS08795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZ22_RS08805	COG1368	sulfuric ester hydrolase activity
GZ22_RS08810	COG1940	carbohydrate kinase activity
GZ22_RS08820	COG1363	Peptidase, m42
GZ22_RS08830	COG0457	Tetratricopeptide repeat
GZ22_RS08830	COG0705	Rhomboid family
GZ22_RS08840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GZ22_RS08860	COG0704	Plays a role in the regulation of phosphate uptake
GZ22_RS08865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZ22_RS08870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZ22_RS08875	COG0581	inorganic phosphate transmembrane transporter activity
GZ22_RS08880	COG0573	inorganic phosphate transmembrane transporter activity
GZ22_RS08885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GZ22_RS08890	COG0768	penicillin binding
GZ22_RS08895	COG0477	Major facilitator Superfamily
GZ22_RS08900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GZ22_RS08935	COG1283	sodium-dependent phosphate transmembrane transporter activity
GZ22_RS08945	COG1388	LysM domain
GZ22_RS08950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GZ22_RS08955	COG4709	membrane
GZ22_RS08965	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GZ22_RS08970	COG0513	Belongs to the DEAD box helicase family
GZ22_RS08975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GZ22_RS08980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GZ22_RS08985	COG2384	SAM-dependent methyltransferase
GZ22_RS08990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GZ22_RS08995	COG0358	DNA primase activity
GZ22_RS09000	COG1671	Belongs to the UPF0178 family
GZ22_RS09010	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GZ22_RS09015	COG0517	IMP dehydrogenase activity
GZ22_RS09020	COG0751	glycine-tRNA ligase activity
GZ22_RS09025	COG0752	glycyl-tRNA synthetase alpha subunit
GZ22_RS09030	COG1381	Involved in DNA repair and RecF pathway recombination
GZ22_RS09035	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GZ22_RS09045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GZ22_RS09050	COG1480	7TM receptor with intracellular HD hydrolase
GZ22_RS09055	COG1702	phosphate starvation-inducible protein PhoH
GZ22_RS09075	COG4864	UPF0365 protein
GZ22_RS09080	COG1030	water channel activity
GZ22_RS09085	COG1610	YqeY-like protein
GZ22_RS09090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GZ22_RS09095	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GZ22_RS09100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZ22_RS09105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GZ22_RS09110	COG2264	protein methyltransferase activity
GZ22_RS09115	COG0484	heat shock protein binding
GZ22_RS09125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GZ22_RS09130	COG1420	regulation of RNA biosynthetic process
GZ22_RS09135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GZ22_RS09140	COG0481	GTPase activity
GZ22_RS09150	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZ22_RS09155	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GZ22_RS09160	COG0268	Binds directly to 16S ribosomal RNA
GZ22_RS09165	COG1466	dna polymerase III delta subunit
GZ22_RS09170	COG0658	competence protein
GZ22_RS09170	COG2333	competence protein COMEC
GZ22_RS09175	COG2131	deaminase
GZ22_RS09180	COG1555	photosystem II stabilization
GZ22_RS09180	COG1596	polysaccharide export
GZ22_RS09185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GZ22_RS09190	COG2226	methyltransferase
GZ22_RS09195	COG0799	negative regulation of ribosome biogenesis
GZ22_RS09200	COG1713	HD superfamily hydrolase involved in NAD metabolism
GZ22_RS09205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GZ22_RS09210	COG1534	Rna-binding protein
GZ22_RS09215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GZ22_RS09220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GZ22_RS09225	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GZ22_RS09235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GZ22_RS09235	COG2111	Na H antiporter
GZ22_RS09240	COG1006	Multisubunit Na H antiporter MnhC subunit
GZ22_RS09245	COG0651	ATP synthesis coupled electron transport
GZ22_RS09250	COG1863	multisubunit Na H antiporter MnhE subunit
GZ22_RS09255	COG2212	antiporter activity
GZ22_RS09260	COG1320	monovalent cation:proton antiporter activity
GZ22_RS09275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GZ22_RS09290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZ22_RS09300	COG4122	O-methyltransferase activity
GZ22_RS09305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GZ22_RS09310	COG3906	Belongs to the UPF0473 family
GZ22_RS09315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GZ22_RS09320	COG4472	Bacterial protein of unknown function (DUF965)
GZ22_RS09330	COG0628	permease
GZ22_RS09340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GZ22_RS09350	COG0482	sulfurtransferase activity
GZ22_RS09355	COG1104	cysteine desulfurase activity
GZ22_RS09360	COG1959	2 iron, 2 sulfur cluster binding
GZ22_RS09365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GZ22_RS09375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GZ22_RS09380	COG0124	histidyl-tRNA synthetase
GZ22_RS09390	COG1490	D-aminoacyl-tRNA deacylase activity
GZ22_RS09395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GZ22_RS09400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZ22_RS09405	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GZ22_RS09405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GZ22_RS09410	COG5416	Lipopolysaccharide assembly protein A domain
GZ22_RS09415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZ22_RS09415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZ22_RS09425	COG2244	polysaccharide biosynthetic process
GZ22_RS09430	COG2323	membrane
GZ22_RS09440	COG1862	Preprotein translocase
GZ22_RS09445	COG0343	queuine tRNA-ribosyltransferase activity
GZ22_RS09450	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GZ22_RS09460	COG2255	four-way junction helicase activity
GZ22_RS09465	COG0632	four-way junction helicase activity
GZ22_RS09485	COG0077	Prephenate dehydratase
GZ22_RS09490	COG4492	Belongs to the UPF0735 family
GZ22_RS09495	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GZ22_RS09500	COG3290	protein histidine kinase activity
GZ22_RS09505	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GZ22_RS09510	COG2868	ribosomal protein
GZ22_RS09515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GZ22_RS09520	COG1530	ribonuclease E activity
GZ22_RS09525	COG1994	Peptidase M50
GZ22_RS09540	COG2860	membrane
GZ22_RS09545	COG2894	cell division
GZ22_RS09550	COG0850	regulation of cytokinetic process
GZ22_RS09565	COG1077	Cell shape determining protein MreB Mrl
GZ22_RS09570	COG2003	Belongs to the UPF0758 family
GZ22_RS09580	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GZ22_RS09590	COG3706	GGDEF domain
GZ22_RS09595	COG0285	dihydrofolate synthase activity
GZ22_RS09600	COG0189	ligase activity
GZ22_RS09605	COG0189	ligase activity
GZ22_RS09615	COG1119	ATPase activity
GZ22_RS09625	COG2197	response regulator
GZ22_RS09630	COG4585	Histidine kinase
GZ22_RS09670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GZ22_RS09680	COG2076	Multidrug Resistance protein
GZ22_RS09685	COG2076	Multidrug Resistance protein
GZ22_RS09700	COG2226	methyltransferase
GZ22_RS09730	COG1064	alcohol dehydrogenase
GZ22_RS09735	COG0789	Transcriptional regulator
GZ22_RS09740	COG2207	Transcriptional regulator
GZ22_RS09745	COG0667	Aldo Keto reductase
GZ22_RS09750	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS09760	COG0738	Major facilitator superfamily
GZ22_RS09770	COG0697	spore germination
GZ22_RS09775	COG1917	Cupin 2, conserved barrel domain protein
GZ22_RS09775	COG2207	Transcriptional regulator
GZ22_RS09780	COG1120	ATPase activity
GZ22_RS09785	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_RS09790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_RS09800	COG1113	amino acid transport
GZ22_RS09815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_RS09820	COG0525	valine-tRNA ligase activity
GZ22_RS09835	COG1388	LysM domain
GZ22_RS09835	COG1388	LysM domain
GZ22_RS09845	COG0113	porphobilinogen synthase activity
GZ22_RS09855	COG0181	hydroxymethylbilane synthase activity
GZ22_RS09860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GZ22_RS09875	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GZ22_RS09880	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GZ22_RS09885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GZ22_RS09890	COG0544	peptidyl-prolyl cis-trans isomerase activity
GZ22_RS09920	COG3773	Cell wall hydrolase
GZ22_RS09935	COG2207	Transcriptional regulator
GZ22_RS09935	COG4753	response regulator
GZ22_RS09940	COG2972	Histidine kinase
GZ22_RS09950	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS09955	COG0673	inositol 2-dehydrogenase activity
GZ22_RS09960	COG5578	integral membrane protein
GZ22_RS09965	COG0395	ABC-type sugar transport system, permease component
GZ22_RS09970	COG1175	transmembrane transport
GZ22_RS09975	COG1653	transport
GZ22_RS09980	COG2814	Major facilitator Superfamily
GZ22_RS09985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GZ22_RS09995	COG2814	Major facilitator Superfamily
GZ22_RS10000	COG1609	Transcriptional regulator
GZ22_RS10015	COG2322	membrane
GZ22_RS10020	COG0622	Phosphoesterase
GZ22_RS10025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GZ22_RS10030	COG5401	PFAM Sporulation and spore germination
GZ22_RS10035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GZ22_RS10040	COG1846	Transcriptional regulator
GZ22_RS10045	COG3263	regulation of cellular component size
GZ22_RS10080	COG2197	response regulator
GZ22_RS10090	COG1247	-acetyltransferase
GZ22_RS10115	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS10125	COG1525	nuclease
GZ22_RS10135	COG2318	DinB family
GZ22_RS10150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZ22_RS10155	COG1309	transcriptional regulator
GZ22_RS10160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GZ22_RS10165	COG1053	succinate dehydrogenase
GZ22_RS10170	COG2009	succinate dehydrogenase
GZ22_RS10175	COG1719	4-vinyl reductase, 4VR
GZ22_RS10200	COG0322	excinuclease ABC activity
GZ22_RS10205	COG3118	belongs to the thioredoxin family
GZ22_RS10210	COG3766	membrane
GZ22_RS10215	COG1193	negative regulation of DNA recombination
GZ22_RS10220	COG1796	DNA polymerase
GZ22_RS10220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GZ22_RS10225	COG1286	toxin biosynthetic process
GZ22_RS10230	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GZ22_RS10235	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GZ22_RS10240	COG1403	HNH endonuclease
GZ22_RS10250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZ22_RS10250	COG0072	phenylalanine-tRNA ligase activity
GZ22_RS10255	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GZ22_RS10260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZ22_RS10270	COG0741	lytic transglycosylase activity
GZ22_RS10275	COG1363	Peptidase, m42
GZ22_RS10290	COG0398	Pfam SNARE associated Golgi protein
GZ22_RS10295	COG3326	Membrane
GZ22_RS10300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GZ22_RS10305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GZ22_RS10310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GZ22_RS10325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZ22_RS10335	COG1484	DNA-dependent DNA replication
GZ22_RS10340	COG3611	Membrane attachment protein
GZ22_RS10345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GZ22_RS10350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZ22_RS10355	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GZ22_RS10360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GZ22_RS10365	COG0237	dephospho-CoA kinase activity
GZ22_RS10370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GZ22_RS10375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZ22_RS10375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZ22_RS10380	COG5002	protein histidine kinase activity
GZ22_RS10385	COG0745	RESPONSE REGULATOR receiver
GZ22_RS10390	COG0039	L-malate dehydrogenase activity
GZ22_RS10395	COG0538	isocitrate dehydrogenase activity
GZ22_RS10400	COG0372	Belongs to the citrate synthase family
GZ22_RS10410	COG0628	permease
GZ22_RS10415	COG3030	protein affecting phage T7 exclusion by the F plasmid
GZ22_RS10430	COG0825	malonyl-CoA metabolic process
GZ22_RS10435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GZ22_RS10440	COG0281	malic enzyme
GZ22_RS10445	COG0587	DNA-directed DNA polymerase activity
GZ22_RS10460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GZ22_RS10465	COG4109	DRTGG domain
GZ22_RS10470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GZ22_RS10475	COG0006	proline dipeptidase activity
GZ22_RS10485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GZ22_RS10490	COG0827	DNA restriction-modification system
GZ22_RS10495	COG3493	citrate carrier protein
GZ22_RS10500	COG0604	alcohol dehydrogenase
GZ22_RS10505	COG4565	transcriptional regulatory protein
GZ22_RS10510	COG3290	protein histidine kinase activity
GZ22_RS10515	COG3874	Sporulation protein YtfJ
GZ22_RS10530	COG0301	tRNA thio-modification
GZ22_RS10535	COG1104	cysteine desulfurase activity
GZ22_RS10540	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GZ22_RS10545	COG1309	transcriptional regulator
GZ22_RS10550	COG1956	GAF domain-containing protein
GZ22_RS10555	COG2203	Gaf domain
GZ22_RS10555	COG2199	diguanylate cyclase activity
GZ22_RS10560	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GZ22_RS10570	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS10585	COG1063	alcohol dehydrogenase
GZ22_RS10590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GZ22_RS10595	COG1063	alcohol dehydrogenase
GZ22_RS10600	COG3775	system Galactitol-specific IIC component
GZ22_RS10605	COG3414	Phosphotransferase system galactitol-specific IIB component
GZ22_RS10615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_RS10625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GZ22_RS10640	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GZ22_RS10640	COG1605	Chorismate mutase
GZ22_RS10655	COG3118	belongs to the thioredoxin family
GZ22_RS10670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GZ22_RS10675	COG1674	ftsk spoiiie
GZ22_RS10680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZ22_RS10685	COG4848	Belongs to the UPF0354 family
GZ22_RS10690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZ22_RS10695	COG0840	transmembrane signaling receptor activity
GZ22_RS10700	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GZ22_RS10705	COG1363	Peptidase, m42
GZ22_RS10715	COG1486	melibiose metabolic process
GZ22_RS10720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GZ22_RS10730	COG0510	thiamine kinase activity
GZ22_RS10740	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GZ22_RS10750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZ22_RS10755	COG1349	DNA-binding transcription factor activity
GZ22_RS10760	COG1187	pseudouridine synthase activity
GZ22_RS10765	COG2244	polysaccharide biosynthetic process
GZ22_RS10770	COG2081	HI0933 family
GZ22_RS10795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GZ22_RS10800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZ22_RS10805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GZ22_RS10810	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GZ22_RS10815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GZ22_RS10820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZ22_RS10825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GZ22_RS10830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZ22_RS10835	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GZ22_RS10840	COG0037	tRNA processing
GZ22_RS10845	COG0515	serine threonine protein kinase
GZ22_RS10850	COG2304	oxidoreductase activity
GZ22_RS10855	COG2208	phosphoserine phosphatase activity
GZ22_RS10865	COG2814	Major facilitator Superfamily
GZ22_RS10870	COG0406	alpha-ribazole phosphatase activity
GZ22_RS10880	COG1098	S1 RNA binding domain
GZ22_RS10900	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GZ22_RS10905	COG3956	TIGRFAM MazG family protein
GZ22_RS10910	COG2244	polysaccharide biosynthetic process
GZ22_RS10925	COG2002	toxin-antitoxin pair type II binding
GZ22_RS10930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GZ22_RS10950	COG1131	(ABC) transporter
GZ22_RS10970	COG1595	DNA-templated transcription, initiation
GZ22_RS10975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GZ22_RS10980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GZ22_RS10995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZ22_RS11000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GZ22_RS11010	COG4466	Protein conserved in bacteria
GZ22_RS11020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GZ22_RS11030	COG0084	hydrolase, TatD family'
GZ22_RS11040	COG2002	toxin-antitoxin pair type II binding
GZ22_RS11045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GZ22_RS11050	COG2827	Endonuclease containing a URI domain
GZ22_RS11055	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GZ22_RS11060	COG4467	Involved in initiation control of chromosome replication
GZ22_RS11065	COG1774	PSP1 C-terminal conserved region
GZ22_RS11070	COG0470	DNA polymerase III
GZ22_RS11075	COG1728	Protein conserved in bacteria
GZ22_RS11080	COG3870	Protein conserved in bacteria
GZ22_RS11085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GZ22_RS11090	COG1982	Orn Lys Arg decarboxylase major
GZ22_RS11150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GZ22_RS11155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GZ22_RS11160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GZ22_RS11165	COG0590	tRNA wobble adenosine to inosine editing
GZ22_RS11170	COG1335	isochorismatase
GZ22_RS11175	COG1388	LysM domain
GZ22_RS11175	COG3858	chitin binding
GZ22_RS11185	COG0693	protein deglycase activity
GZ22_RS11190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZ22_RS11195	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_RS11210	COG0697	spore germination
GZ22_RS11230	COG1428	Deoxynucleoside kinase
GZ22_RS11235	COG1428	Deoxynucleoside kinase
GZ22_RS11255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GZ22_RS11265	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GZ22_RS11280	COG2358	TRAP transporter, solute receptor (TAXI family
GZ22_RS11285	COG0516	GMP reductase activity
GZ22_RS11285	COG0517	IMP dehydrogenase activity
GZ22_RS11300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GZ22_RS11305	COG0187	DNA topoisomerase II activity
GZ22_RS11315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GZ22_RS11320	COG2501	S4 domain
GZ22_RS11325	COG0592	DNA-directed DNA polymerase activity
GZ22_RS11330	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GZ22_RS11335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GZ22_RS11340	COG0594	ribonuclease P activity
GZ22_RS11345	COG0706	membrane insertase activity
GZ22_RS11350	COG1847	R3H domain protein
GZ22_RS11355	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GZ22_RS11360	COG0445	tRNA wobble uridine modification
GZ22_RS11365	COG0357	Ribosomal RNA small subunit methyltransferase G
GZ22_RS11370	COG1475	DNA binding
GZ22_RS11375	COG1192	Involved in chromosome partitioning
GZ22_RS11380	COG1475	DNA binding
GZ22_RS11390	COG3949	Membrane
GZ22_RS11395	COG0668	transmembrane transport
GZ22_RS11400	COG4481	Protein conserved in bacteria
GZ22_RS11405	COG0012	GTP binding
GZ22_RS11410	COG0360	Binds together with S18 to 16S ribosomal RNA
GZ22_RS11415	COG0629	single-stranded DNA binding
GZ22_RS11420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GZ22_RS11425	COG2814	Major facilitator Superfamily
GZ22_RS11430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GZ22_RS11440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZ22_RS11445	COG0531	amino acid
GZ22_RS11455	COG4241	membrane
GZ22_RS11460	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GZ22_RS11465	COG0359	binds to the 23S rRNA
GZ22_RS11470	COG0305	Participates in initiation and elongation during chromosome replication
GZ22_RS11475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GZ22_RS11480	COG0745	RESPONSE REGULATOR receiver
GZ22_RS11485	COG5002	protein histidine kinase activity
GZ22_RS11490	COG4863	YycH protein
GZ22_RS11495	COG4853	Protein conserved in bacteria
GZ22_RS11500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GZ22_RS11505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZ22_RS11510	COG1511	domain protein
GZ22_RS11515	COG1309	transcriptional regulator
GZ22_RS11520	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS11520	COG2202	Pas domain
GZ22_RS11525	COG1482	cell wall glycoprotein biosynthetic process
GZ22_RS11530	COG0768	penicillin binding
GZ22_RS11540	COG0833	amino acid
GZ22_RS11545	COG0154	amidase activity
GZ22_RS11555	COG1113	amino acid transport
GZ22_RS11560	COG1136	(ABC) transporter
GZ22_RS11565	COG0577	efflux transmembrane transporter activity
GZ22_RS11570	COG0745	RESPONSE REGULATOR receiver
GZ22_RS11575	COG5002	protein histidine kinase activity
GZ22_RS11610	COG1609	Transcriptional regulator
GZ22_RS11615	COG1486	melibiose metabolic process
GZ22_RS11620	COG1609	Transcriptional regulator
GZ22_RS11625	COG0561	phosphatase activity
GZ22_RS11630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZ22_RS11635	COG0534	Mate efflux family protein
GZ22_RS11640	COG0772	Belongs to the SEDS family
GZ22_RS11660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GZ22_RS11665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GZ22_RS11670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZ22_RS11675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_RS11680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_RS11685	COG2819	hydrolase of the alpha beta superfamily
GZ22_RS11730	COG1174	glycine betaine transport
GZ22_RS11735	COG1732	Glycine betaine
GZ22_RS11745	COG0517	IMP dehydrogenase activity
GZ22_RS11745	COG1125	glycine betaine transport
GZ22_RS11785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GZ22_RS11795	COG0640	Transcriptional regulator
GZ22_RS11800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GZ22_RS11805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZ22_RS11815	COG2723	6-phospho-beta-galactosidase activity
GZ22_RS11820	COG1447	Phosphotransferase system cellobiose-specific component IIA
GZ22_RS11840	COG0745	RESPONSE REGULATOR receiver
GZ22_RS11845	COG2205	protein histidine kinase activity
GZ22_RS11850	COG1136	(ABC) transporter
GZ22_RS11855	COG0577	efflux transmembrane transporter activity
GZ22_RS11860	COG1388	LysM domain
GZ22_RS11870	COG0601	transmembrane transport
GZ22_RS11880	COG0444	Belongs to the ABC transporter superfamily
GZ22_RS11885	COG4608	Belongs to the ABC transporter superfamily
GZ22_RS11890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZ22_RS11915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_RS11920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_RS11935	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS11940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZ22_RS11945	COG0586	Pfam SNARE associated Golgi protein
GZ22_RS11955	COG3619	membrane
GZ22_RS11960	COG1316	TRANSCRIPTIONal
GZ22_RS11970	COG1309	transcriptional regulator
GZ22_RS11985	COG3011	Protein conserved in bacteria
GZ22_RS11990	COG3420	alginic acid biosynthetic process
GZ22_RS12010	COG1280	lysine exporter protein (LysE YggA)
GZ22_RS12015	COG4335	DNA alkylation repair
GZ22_RS12030	COG2207	Transcriptional regulator
GZ22_RS12040	COG1660	Displays ATPase and GTPase activities
GZ22_RS12045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GZ22_RS12055	COG0475	glutathione-regulated potassium exporter activity
GZ22_RS12065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_RS12070	COG2223	nitrite transmembrane transporter activity
GZ22_RS12075	COG3279	Response regulator of the LytR AlgR family
GZ22_RS12080	COG3275	phosphorelay sensor kinase activity
GZ22_RS12085	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GZ22_RS12090	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS12100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZ22_RS12105	COG1414	Transcriptional regulator
GZ22_RS12110	COG0800	Aldolase
GZ22_RS12135	COG4221	oxidoreductase activity
GZ22_RS12145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GZ22_RS12160	COG2205	protein histidine kinase activity
GZ22_RS12180	COG1051	belongs to the nudix hydrolase family
GZ22_RS12185	COG2318	DinB family
GZ22_RS12190	COG0716	FMN binding
GZ22_RS12195	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZ22_RS12200	COG3711	transcriptional antiterminator
GZ22_RS12225	COG2076	Multidrug Resistance protein
GZ22_RS12230	COG2076	Multidrug Resistance protein
GZ22_RS12235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_RS12240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_RS12245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZ22_RS12250	COG0492	ferredoxin-NADP+ reductase activity
GZ22_RS12260	COG0473	3-isopropylmalate dehydrogenase activity
GZ22_RS12265	COG1253	flavin adenine dinucleotide binding
GZ22_RS12270	COG1349	DNA-binding transcription factor activity
GZ22_RS12275	COG3395	kinase activity
GZ22_RS12280	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GZ22_RS12295	COG0772	Belongs to the SEDS family
GZ22_RS12300	COG0772	Belongs to the SEDS family
GZ22_RS12305	COG1522	sequence-specific DNA binding
GZ22_RS12310	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GZ22_RS12315	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS12320	COG0366	Alpha amylase catalytic
GZ22_RS12335	COG5386	Cell surface protein
GZ22_RS12340	COG5386	Cell surface protein
GZ22_RS12355	COG1120	ATPase activity
GZ22_RS12360	COG4509	Sortase family
GZ22_RS12370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_RS12375	COG1120	ATPase activity
GZ22_RS12395	COG0477	Major facilitator Superfamily
GZ22_RS12400	COG2030	dehydratase
GZ22_RS12450	COG0778	Nitroreductase
GZ22_RS12455	COG0346	lactoylglutathione lyase activity
GZ22_RS12460	COG0346	lactoylglutathione lyase activity
GZ22_RS12465	COG0400	carboxylic ester hydrolase activity
GZ22_RS12470	COG0655	NAD(P)H dehydrogenase (quinone) activity
GZ22_RS12485	COG0673	inositol 2-dehydrogenase activity
GZ22_RS12490	COG0457	Tetratricopeptide repeat
GZ22_RS12500	COG1215	transferase activity, transferring glycosyl groups
GZ22_RS12510	COG0768	penicillin binding
GZ22_RS12525	COG3715	PTS system
GZ22_RS12530	COG3716	PTS system mannose fructose sorbose family IID component
GZ22_RS12535	COG0673	inositol 2-dehydrogenase activity
GZ22_RS12550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_RS12550	COG2190	(PTS) system
GZ22_RS12550	COG1263	PTS System
GZ22_RS12555	COG2723	6-phospho-beta-galactosidase activity
GZ22_RS12560	COG3711	transcriptional antiterminator
GZ22_RS12575	COG1879	ABC-type sugar transport system periplasmic component
GZ22_RS12580	COG1129	ABC transporter
GZ22_RS12585	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZ22_RS12595	COG1802	Transcriptional regulator
GZ22_RS12600	COG3395	kinase activity
GZ22_RS12625	COG4585	Histidine kinase
GZ22_RS12630	COG2197	response regulator
GZ22_RS12640	COG3142	Participates in the control of copper homeostasis
GZ22_RS12645	COG0733	neurotransmitter:sodium symporter activity
GZ22_RS12650	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GZ22_RS12655	COG0823	Involved in the tonB-independent uptake of proteins
GZ22_RS12655	COG1506	peptidase
GZ22_RS12655	COG4946	Tricorn protease homolog
GZ22_RS12660	COG1228	amidohydrolase
GZ22_RS12665	COG0601	transmembrane transport
GZ22_RS12670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZ22_RS12675	COG0444	Belongs to the ABC transporter superfamily
GZ22_RS12680	COG4608	Belongs to the ABC transporter superfamily
GZ22_RS12685	COG4166	transmembrane transport
GZ22_RS12695	COG1695	Transcriptional regulator
GZ22_RS12705	COG1612	heme a metabolic process
GZ22_RS12710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GZ22_RS12725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GZ22_RS12760	COG0385	Bile acid
GZ22_RS12770	COG5002	protein histidine kinase activity
GZ22_RS12775	COG5002	protein histidine kinase activity
GZ22_RS12780	COG2226	methyltransferase
GZ22_RS12785	COG5504	Zn-dependent protease
GZ22_RS12795	COG1113	amino acid transport
GZ22_RS12815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZ22_RS12835	COG3290	protein histidine kinase activity
GZ22_RS12835	COG0840	transmembrane signaling receptor activity
GZ22_RS12840	COG0745	RESPONSE REGULATOR receiver
GZ22_RS12845	COG2205	protein histidine kinase activity
GZ22_RS12850	COG1131	(ABC) transporter
GZ22_RS12860	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GZ22_RS12865	COG0402	S-adenosylhomocysteine deaminase activity
GZ22_RS12935	COG0670	Belongs to the BI1 family
GZ22_RS12945	COG3588	fructose-bisphosphate aldolase
GZ22_RS12950	COG2972	Histidine kinase
GZ22_RS12955	COG4753	response regulator
GZ22_RS12955	COG2207	Transcriptional regulator
GZ22_RS12960	COG2182	Extracellular solute-binding protein
GZ22_RS12965	COG1621	beta-fructofuranosidase activity
GZ22_RS12970	COG1621	beta-fructofuranosidase activity
GZ22_RS12975	COG1914	H( )-stimulated, divalent metal cation uptake system
GZ22_RS12980	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GZ22_RS12985	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GZ22_RS12990	COG1984	allophanate hydrolase subunit 2
GZ22_RS13000	COG3634	alkyl hydroperoxide reductase activity
GZ22_RS13005	COG0450	alkyl hydroperoxide reductase
GZ22_RS13010	COG0840	transmembrane signaling receptor activity
GZ22_RS13015	COG1785	Belongs to the alkaline phosphatase family
GZ22_RS13020	COG3858	chitin binding
GZ22_RS13030	COG0697	spore germination
GZ22_RS13040	COG4509	Sortase family
GZ22_RS13055	COG1917	Cupin 2, conserved barrel domain protein
GZ22_RS13055	COG2207	Transcriptional regulator
GZ22_RS13065	COG3546	catalase activity
GZ22_RS13075	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GZ22_RS13080	COG1757	Na H antiporter
GZ22_RS13085	COG2323	membrane
GZ22_RS13100	COG5039	Polysaccharide pyruvyl transferase
GZ22_RS13105	COG1288	antiporter activity
GZ22_RS13110	COG1473	amidohydrolase
GZ22_RS13115	COG0492	ferredoxin-NADP+ reductase activity
GZ22_RS13120	COG1959	2 iron, 2 sulfur cluster binding
GZ22_RS13130	COG0583	DNA-binding transcription factor activity
GZ22_RS13150	COG2186	Transcriptional regulator
GZ22_RS13155	COG0247	lactate metabolic process
GZ22_RS13160	COG1139	Iron-sulfur cluster binding protein
GZ22_RS13165	COG1556	Lactate utilization protein
GZ22_RS13195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZ22_RS13200	COG2011	ABC-type metal ion transport system permease component
GZ22_RS13220	COG1279	arginine transmembrane transporter activity
GZ22_RS13230	COG1114	Component of the transport system for branched-chain amino acids
GZ22_RS13250	COG0457	Tetratricopeptide repeat
GZ22_RS13265	COG0110	maltose O-acetyltransferase activity
GZ22_RS13290	COG2017	converts alpha-aldose to the beta-anomer
GZ22_RS13300	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GZ22_RS13305	COG1609	Transcriptional regulator
GZ22_RS13310	COG2182	Extracellular solute-binding protein
GZ22_RS13315	COG1175	transmembrane transport
GZ22_RS13320	COG3833	ABC-type maltose transport systems, permease component
GZ22_RS13325	COG1874	Beta-galactosidase
GZ22_RS13330	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS13345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZ22_RS13350	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_RS13355	COG2271	Major facilitator Superfamily
GZ22_RS13360	COG4948	Mandelate Racemase Muconate Lactonizing
GZ22_RS13365	COG2186	Transcriptional regulator
GZ22_RS13375	COG0657	acetylesterase activity
GZ22_RS13380	COG3069	C4-dicarboxylate transmembrane transporter activity
GZ22_RS13385	COG1263	PTS System
GZ22_RS13385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_RS13385	COG2190	(PTS) system
GZ22_RS13390	COG2723	6-phospho-beta-galactosidase activity
GZ22_RS13405	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GZ22_RS13410	COG1177	transmembrane transport
GZ22_RS13415	COG1176	ABC-type spermidine putrescine transport system, permease component I
GZ22_RS13450	COG1216	Glycosyl transferase, family 2
GZ22_RS13450	COG0463	Glycosyl transferase, family 2
GZ22_RS13455	COG0438	transferase activity, transferring glycosyl groups
GZ22_RS13465	COG1086	Polysaccharide biosynthesis protein
GZ22_RS13485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZ22_RS13505	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GZ22_RS13515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZ22_RS13515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZ22_RS13525	COG0561	phosphatase activity
GZ22_RS13540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZ22_RS13545	COG2514	catechol 2,3-dioxygenase activity
GZ22_RS13555	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZ22_RS13560	COG0463	Glycosyl transferase, family 2
GZ22_RS13570	COG3706	GGDEF domain
GZ22_RS13570	COG2203	Gaf domain
GZ22_RS13570	COG5001	Diguanylate cyclase
GZ22_RS13570	COG4251	negative regulation of phosphorylation
GZ22_RS13615	COG2721	sulfolactate sulfo-lyase activity
GZ22_RS13620	COG0477	Major facilitator Superfamily
GZ22_RS13625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZ22_RS13630	COG0765	amino acid transport
GZ22_RS13635	COG1126	abc transporter atp-binding protein
GZ22_RS13645	COG0583	DNA-binding transcription factor activity
GZ22_RS13650	COG1063	alcohol dehydrogenase
GZ22_RS13655	COG0667	Aldo Keto reductase
GZ22_RS13670	COG1073	alpha beta
GZ22_RS13675	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_RS13680	COG0400	carboxylic ester hydrolase activity
GZ22_RS13685	COG1846	Transcriptional regulator
GZ22_RS13690	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZ22_RS13695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZ22_RS13705	COG2211	Major facilitator Superfamily
GZ22_RS13720	COG0640	Transcriptional regulator
GZ22_RS13725	COG0659	secondary active sulfate transmembrane transporter activity
GZ22_RS13740	COG4294	response to UV
GZ22_RS13750	COG1842	Phage shock protein A
GZ22_RS13760	COG3766	membrane
GZ22_RS13765	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GZ22_RS13770	COG1522	sequence-specific DNA binding
GZ22_RS13775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZ22_RS13795	COG1742	UPF0060 membrane protein
GZ22_RS13805	COG1174	glycine betaine transport
GZ22_RS13820	COG1979	alcohol dehydrogenase
GZ22_RS13830	COG0385	Bile acid
GZ22_RS13840	COG1653	transport
GZ22_RS13850	COG1175	transmembrane transport
GZ22_RS13855	COG3842	ATPase activity
GZ22_RS13865	COG0584	glycerophosphoryl diester phosphodiesterase
GZ22_RS13870	COG0789	Transcriptional regulator
GZ22_RS13875	COG0415	Belongs to the DNA photolyase family
GZ22_RS13880	COG1464	Belongs to the NlpA lipoprotein family
GZ22_RS13885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZ22_RS13890	COG2011	ABC-type metal ion transport system permease component
GZ22_RS13895	COG0306	phosphate transporter
GZ22_RS13900	COG1392	Phosphate transport regulator
GZ22_RS13905	COG4841	protein insertion into membrane
GZ22_RS13920	COG0765	amino acid transport
GZ22_RS13930	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GZ22_RS13935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZ22_RS13940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GZ22_RS13955	COG3842	ATPase activity
GZ22_RS13960	COG2318	DinB family
GZ22_RS13965	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS13980	COG0246	Mannitol dehydrogenase
GZ22_RS13985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_RS13990	COG3711	transcriptional antiterminator
GZ22_RS14000	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GZ22_RS14005	COG1360	Flagellar Motor Protein
GZ22_RS14015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GZ22_RS14025	COG0179	Fumarylacetoacetate (FAA) hydrolase
GZ22_RS14040	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GZ22_RS14045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GZ22_RS14050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZ22_RS14055	COG0788	formyltetrahydrofolate deformylase activity
GZ22_RS14060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZ22_RS14065	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GZ22_RS14070	COG2130	NADP-dependent
GZ22_RS14075	COG4876	unkown
GZ22_RS14085	COG0251	oxidation-reduction process
GZ22_RS14090	COG2814	Major facilitator Superfamily
GZ22_RS14095	COG3973	AAA domain
GZ22_RS14100	COG0471	metal ion transport
GZ22_RS14105	COG2084	Dehydrogenase
GZ22_RS14110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_RS14115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZ22_RS14125	COG2309	aminopeptidase activity
GZ22_RS14150	COG0346	lactoylglutathione lyase activity
GZ22_RS14155	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GZ22_RS14160	COG2056	Na+-H+ antiporter family
GZ22_RS14170	COG1525	nuclease
GZ22_RS14170	COG0737	Belongs to the 5'-nucleotidase family
GZ22_RS14170	COG4085	toxin activity
GZ22_RS14175	COG1757	Na H antiporter
GZ22_RS14180	COG1027	Aspartate ammonia-lyase
GZ22_RS14185	COG0252	asparaginase activity
GZ22_RS14190	COG1396	sequence-specific DNA binding
GZ22_RS14195	COG1120	ATPase activity
GZ22_RS14200	COG0778	Nitroreductase
GZ22_RS14210	COG3639	organic phosphonate transmembrane transporter activity
GZ22_RS14225	COG0737	Belongs to the 5'-nucleotidase family
GZ22_RS14230	COG1388	LysM domain
GZ22_RS14230	COG3584	3D domain protein
GZ22_RS14240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GZ22_RS14245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GZ22_RS14245	COG0512	Glutamine amidotransferase of anthranilate synthase
GZ22_RS14250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GZ22_RS14270	COG0159	tryptophan synthase activity
GZ22_RS14275	COG4152	abc transporter atp-binding protein
GZ22_RS14280	COG1668	transmembrane transport
GZ22_RS14290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZ22_RS14300	COG0488	(ABC) transporter
GZ22_RS14315	COG2124	cytochrome p450
GZ22_RS14355	COG2197	response regulator
GZ22_RS14365	COG2755	lipolytic protein G-D-S-L family
GZ22_RS14380	COG2962	Rard protein
GZ22_RS14385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GZ22_RS14390	COG1607	acyl-coa hydrolase
GZ22_RS14395	COG0840	transmembrane signaling receptor activity
GZ22_RS14405	COG0351	phosphomethylpyrimidine kinase
GZ22_RS14410	COG0488	(ABC) transporter
GZ22_RS14420	COG0514	ATP-dependent DNA helicase (RecQ)
GZ22_RS14425	COG1253	flavin adenine dinucleotide binding
GZ22_RS14440	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GZ22_RS14440	COG1605	Chorismate mutase
GZ22_RS14445	COG2814	Major facilitator Superfamily
GZ22_RS14450	COG0628	permease
GZ22_RS14455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZ22_RS14460	COG0861	Integral membrane protein TerC family
GZ22_RS14465	COG1764	response to oxidative stress
GZ22_RS14475	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZ22_RS14475	COG3443	Belongs to the bacterial solute-binding protein 9 family
GZ22_RS14485	COG1793	dna ligase
GZ22_RS14485	COG3285	dna ligase
GZ22_RS14490	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GZ22_RS14495	COG3594	Acyltransferase
GZ22_RS14505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GZ22_RS14520	COG2363	Small membrane protein
GZ22_RS14530	COG3253	May function as heme-dependent peroxidase
GZ22_RS14535	COG0280	phosphate acetyltransferase
GZ22_RS14540	COG2202	Pas domain
GZ22_RS14540	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS14545	COG0095	Lipoate-protein ligase
GZ22_RS14550	COG1078	dGTPase activity
GZ22_RS14555	COG3465	dGTPase activity
GZ22_RS14575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZ22_RS14580	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GZ22_RS14595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GZ22_RS14605	COG3343	RNA polymerase activity
GZ22_RS14610	COG0504	CTP synthase activity
GZ22_RS14615	COG2204	response regulator
GZ22_RS14620	COG0191	fructose-bisphosphate aldolase activity
GZ22_RS14625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GZ22_RS14630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZ22_RS14635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GZ22_RS14640	COG0254	rRNA binding
GZ22_RS14645	COG1435	thymidine kinase activity
GZ22_RS14655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GZ22_RS14660	COG2890	protein-(glutamine-N5) methyltransferase activity
GZ22_RS14675	COG0009	L-threonylcarbamoyladenylate synthase
GZ22_RS14685	COG0840	transmembrane signaling receptor activity
GZ22_RS14690	COG0698	ribose 5-phosphate isomerase
GZ22_RS14695	COG4475	Protein of unknown function (DUF436)
GZ22_RS14700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GZ22_RS14705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GZ22_RS14710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GZ22_RS14715	COG1404	Belongs to the peptidase S8 family
GZ22_RS14725	COG0356	it plays a direct role in the translocation of protons across the membrane
GZ22_RS14735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GZ22_RS14740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZ22_RS14745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GZ22_RS14750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GZ22_RS14755	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GZ22_RS14760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GZ22_RS14765	COG4836	Membrane
GZ22_RS14775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZ22_RS14780	COG2362	D-Aminopeptidase
GZ22_RS14785	COG0601	transmembrane transport
GZ22_RS14790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZ22_RS14795	COG0444	Belongs to the ABC transporter superfamily
GZ22_RS14800	COG4166	transmembrane transport
GZ22_RS14805	COG1619	proteins homologs of microcin C7 resistance protein MccF
GZ22_RS14810	COG4948	Mandelate Racemase Muconate Lactonizing
GZ22_RS14815	COG0791	NLP P60 protein
GZ22_RS14820	COG2385	sporulation resulting in formation of a cellular spore
GZ22_RS14825	COG0739	heme binding
GZ22_RS14835	COG1609	Transcriptional regulator
GZ22_RS14840	COG1077	Cell shape determining protein MreB Mrl
GZ22_RS14845	COG4786	Flagellar basal body rod
GZ22_RS14850	COG4786	Flagellar basal body rod
GZ22_RS14860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GZ22_RS14890	COG0438	transferase activity, transferring glycosyl groups
GZ22_RS14900	COG2002	toxin-antitoxin pair type II binding
GZ22_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS14935	COG0728	peptidoglycan biosynthetic process
GZ22_RS14955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GZ22_RS14960	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZ22_RS14965	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GZ22_RS14970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZ22_RS15010	COG1682	transport, permease protein
GZ22_RS15015	COG1316	TRANSCRIPTIONal
GZ22_RS15040	COG2851	Citrate transporter
GZ22_RS15055	COG1940	carbohydrate kinase activity
GZ22_RS15065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GZ22_RS15070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZ22_RS15075	COG3386	PFAM SMP-30 Gluconolaconase
GZ22_RS15080	COG0457	Tetratricopeptide repeat
GZ22_RS15085	COG0534	Mate efflux family protein
GZ22_RS15100	COG2172	sigma factor antagonist activity
GZ22_RS15105	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GZ22_RS15110	COG1388	LysM domain
GZ22_RS15110	COG0791	NLP P60 protein
GZ22_RS15115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GZ22_RS15120	COG3944	biosynthesis protein
GZ22_RS15125	COG0489	protein tyrosine kinase activity
GZ22_RS15130	COG4464	protein tyrosine phosphatase activity
GZ22_RS15135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GZ22_RS15145	COG0438	transferase activity, transferring glycosyl groups
GZ22_RS15150	COG0662	Cupin 2, conserved barrel domain protein
GZ22_RS15150	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GZ22_RS15170	COG4464	protein tyrosine phosphatase activity
GZ22_RS15205	COG1113	amino acid transport
GZ22_RS15210	COG1280	lysine exporter protein (LysE YggA)
GZ22_RS15220	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GZ22_RS15235	COG2723	6-phospho-beta-galactosidase activity
GZ22_RS15245	COG0346	lactoylglutathione lyase activity
GZ22_RS15255	COG0248	Ppx GppA phosphatase
GZ22_RS15295	COG1215	transferase activity, transferring glycosyl groups
GZ22_RS15305	COG0506	proline dehydrogenase activity
GZ22_RS15310	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_RS15320	COG0523	cobalamin synthesis protein
GZ22_RS15325	COG0523	cobalamin synthesis protein
GZ22_RS15330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GZ22_RS15335	COG0523	cobalamin synthesis protein
GZ22_RS15345	COG0840	transmembrane signaling receptor activity
GZ22_RS15350	COG2508	Transcriptional regulator
GZ22_RS15365	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZ22_RS15370	COG1447	Phosphotransferase system cellobiose-specific component IIA
GZ22_RS15375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZ22_RS15380	COG2723	6-phospho-beta-galactosidase activity
GZ22_RS15385	COG2188	Transcriptional regulator
GZ22_RS15390	COG1737	Transcriptional regulator
GZ22_RS15395	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GZ22_RS15415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZ22_RS15425	COG1917	Cupin 2, conserved barrel domain protein
GZ22_RS15425	COG4977	sequence-specific DNA binding
GZ22_RS15485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZ22_RS15490	COG1309	transcriptional regulator
GZ22_RS15495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZ22_RS15500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZ22_RS15505	COG1447	Phosphotransferase system cellobiose-specific component IIA
GZ22_RS15510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_RS15510	COG3711	transcriptional antiterminator
GZ22_RS15530	COG1472	Belongs to the glycosyl hydrolase 3 family
GZ22_RS15535	COG1846	Transcriptional regulator
GZ22_RS15540	COG2409	Drug exporters of the RND superfamily
GZ22_RS15540	COG1033	growth of symbiont in host cell
GZ22_RS15555	COG2267	carboxylic ester hydrolase activity
GZ22_RS15575	COG1011	Hydrolase
GZ22_RS15580	COG0561	phosphatase activity
GZ22_RS15590	COG2059	Chromate
GZ22_RS15595	COG2059	Chromate
GZ22_RS15610	COG0205	6-phosphofructokinase activity
GZ22_RS15630	COG0673	inositol 2-dehydrogenase activity
GZ22_RS15635	COG1082	Xylose isomerase domain protein TIM barrel
GZ22_RS15645	COG0559	Belongs to the binding-protein-dependent transport system permease family
GZ22_RS15665	COG1737	Transcriptional regulator
GZ22_RS15670	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GZ22_RS15675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZ22_RS15675	COG1263	PTS System
GZ22_RS15685	COG1301	dicarboxylic acid transport
GZ22_RS15695	COG2186	Transcriptional regulator
GZ22_RS15700	COG3764	Sortase (surface protein transpeptidase)
GZ22_RS15710	COG2188	Transcriptional regulator
GZ22_RS15715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GZ22_RS15720	COG0363	glucosamine-6-phosphate deaminase activity
GZ22_RS15725	COG1739	Uncharacterized protein family UPF0029
GZ22_RS15730	COG4585	Histidine kinase
GZ22_RS15740	COG1307	EDD domain protein, DegV family
GZ22_RS15745	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GZ22_RS15750	COG1040	competence protein
GZ22_RS15760	COG2747	anti-sigma28 factor FlgM
GZ22_RS15770	COG1256	bacterial-type flagellum assembly
GZ22_RS15770	COG4786	Flagellar basal body rod
GZ22_RS15775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GZ22_RS15785	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GZ22_RS15790	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GZ22_RS15795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GZ22_RS15805	COG0438	transferase activity, transferring glycosyl groups
GZ22_RS15815	COG1366	Belongs to the anti-sigma-factor antagonist family
GZ22_RS15820	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS15825	COG1334	flagellar protein FlaG
GZ22_RS15830	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GZ22_RS15835	COG1516	flagellar protein fliS
GZ22_RS15845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GZ22_RS15850	COG0653	protein targeting
GZ22_RS15865	COG2884	Cell division ATP-binding protein ftsE
GZ22_RS15870	COG2177	Part of the ABC transporter FtsEX involved in
GZ22_RS15875	COG0739	heme binding
GZ22_RS15880	COG0793	Belongs to the peptidase S41A family
GZ22_RS15880	COG3409	Peptidoglycan-binding domain 1 protein
GZ22_RS15885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZ22_RS15900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZ22_RS15910	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GZ22_RS15915	COG0556	nucleotide-excision repair
GZ22_RS15920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GZ22_RS15925	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GZ22_RS15935	COG3595	metallopeptidase activity
GZ22_RS15940	COG1950	PFAM Membrane protein of
GZ22_RS15945	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GZ22_RS15950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GZ22_RS15955	COG0546	phosphoglycolate phosphatase activity
GZ22_RS15960	COG0110	maltose O-acetyltransferase activity
GZ22_RS15965	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GZ22_RS15970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GZ22_RS15975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GZ22_RS15980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GZ22_RS15985	COG0457	Tetratricopeptide repeat
GZ22_RS15990	COG0492	ferredoxin-NADP+ reductase activity
GZ22_RS15995	COG1051	belongs to the nudix hydrolase family
GZ22_RS16000	COG1660	Displays ATPase and GTPase activities
GZ22_RS16005	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GZ22_RS16010	COG1481	regulation of sporulation
GZ22_RS16015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_RS16020	COG0616	signal peptide processing
GZ22_RS16025	COG1714	RDD family
GZ22_RS16030	COG0740	serine-type endopeptidase activity
GZ22_RS16035	COG3546	catalase activity
GZ22_RS16065	COG1404	Belongs to the peptidase S8 family
GZ22_RS16090	COG1012	belongs to the aldehyde dehydrogenase family
GZ22_RS16095	COG0028	Belongs to the TPP enzyme family
GZ22_RS16100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GZ22_RS16105	COG2814	Major facilitator Superfamily
GZ22_RS16110	COG3546	catalase activity
GZ22_RS16125	COG0519	Catalyzes the synthesis of GMP from XMP
GZ22_RS16140	COG0347	Belongs to the P(II) protein family
GZ22_RS16145	COG0004	ammonium transporteR
GZ22_RS16150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GZ22_RS16165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZ22_RS16170	COG1116	anion transmembrane transporter activity
GZ22_RS16175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZ22_RS16185	COG2204	response regulator
GZ22_RS16195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GZ22_RS16200	COG0534	Mate efflux family protein
GZ22_RS16210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GZ22_RS16215	COG0126	phosphoglycerate kinase activity
GZ22_RS16220	COG0149	triose-phosphate isomerase activity
GZ22_RS16225	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GZ22_RS16230	COG0148	phosphopyruvate hydratase activity
GZ22_RS16265	COG0300	oxidoreductase activity
GZ22_RS16275	COG1082	Xylose isomerase domain protein TIM barrel
GZ22_RS16280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZ22_RS16285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_RS16290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_RS16290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZ22_RS16290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZ22_RS16295	COG1105	Belongs to the carbohydrate kinase PfkB family
GZ22_RS16300	COG1349	DNA-binding transcription factor activity
GZ22_RS16305	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GZ22_RS16310	COG1647	Serine aminopeptidase, S33
GZ22_RS16315	COG0557	exoribonuclease II activity
GZ22_RS16325	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GZ22_RS16330	COG0024	Methionine aminopeptidase
GZ22_RS16350	COG0753	catalase activity
GZ22_RS16355	COG3706	GGDEF domain
GZ22_RS16365	COG1413	lyase activity
GZ22_RS16370	COG0586	Pfam SNARE associated Golgi protein
GZ22_RS16375	COG1968	undecaprenyl-diphosphatase activity
GZ22_RS16385	COG5577	PFAM Coat F domain
GZ22_RS16400	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZ22_RS16405	COG4605	iron ion homeostasis
GZ22_RS16410	COG4604	ABC transporter, ATP-binding protein
GZ22_RS16415	COG4607	ABC-type enterochelin transport system periplasmic component
GZ22_RS16420	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GZ22_RS16430	COG2814	Major facilitator Superfamily
GZ22_RS16440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GZ22_RS16445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZ22_RS16460	COG1960	acyl-CoA dehydrogenase activity
GZ22_RS16465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZ22_RS16475	COG0659	secondary active sulfate transmembrane transporter activity
GZ22_RS16490	COG1942	4-Oxalocrotonate Tautomerase
GZ22_RS16495	COG0735	belongs to the Fur family
GZ22_RS16500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZ22_RS16505	COG1121	(ABC) transporter
GZ22_RS16510	COG1937	Protein conserved in bacteria
GZ22_RS16515	COG2217	Heavy metal translocating P-type atpase
GZ22_RS16535	COG5577	PFAM Coat F domain
GZ22_RS16545	COG1393	Belongs to the ArsC family
GZ22_RS16550	COG0509	glycine decarboxylation via glycine cleavage system
GZ22_RS16555	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GZ22_RS16560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZ22_RS16570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZ22_RS16575	COG2011	ABC-type metal ion transport system permease component
GZ22_RS16580	COG1464	Belongs to the NlpA lipoprotein family
GZ22_RS16585	COG0396	ATPase activity
GZ22_RS16590	COG0719	Fe-S assembly protein
GZ22_RS16595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GZ22_RS16600	COG0822	iron-sulfur transferase activity
GZ22_RS16605	COG0719	Fe-S assembly protein
GZ22_RS16625	COG3655	Transcriptional regulator
GZ22_RS16630	COG3739	integral membrane protein
GZ22_RS16635	COG1028	Short-chain dehydrogenase reductase Sdr
GZ22_RS16640	COG0730	response to heat
GZ22_RS16645	COG0737	Belongs to the 5'-nucleotidase family
GZ22_RS16650	COG3377	Domain of unknown function (DUF1805)
GZ22_RS16665	COG0739	heme binding
GZ22_RS16670	COG4470	Protein conserved in bacteria
GZ22_RS16675	COG2445	Protein of unknown function DUF86
GZ22_RS16680	COG0647	UMP catabolic process
GZ22_RS16685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GZ22_RS16690	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GZ22_RS16695	COG0460	homoserine dehydrogenase
GZ22_RS16700	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GZ22_RS16705	COG0083	homoserine kinase activity
GZ22_RS16710	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GZ22_RS16715	COG4837	Protein of unknown function (DUF1462)
GZ22_RS16725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GZ22_RS16730	COG0316	Belongs to the HesB IscA family
GZ22_RS16735	COG0346	lactoylglutathione lyase activity
GZ22_RS16745	COG2814	Major facilitator Superfamily
GZ22_RS16750	COG2814	Major facilitator Superfamily
GZ22_RS16755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZ22_RS16765	COG1252	NADH dehydrogenase
GZ22_RS16775	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GZ22_RS16780	COG1268	BioY protein
GZ22_RS16785	COG0813	purine-nucleoside phosphorylase activity
GZ22_RS16790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZ22_RS16805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GZ22_RS16810	COG2267	carboxylic ester hydrolase activity
GZ22_RS16815	COG1098	S1 RNA binding domain
GZ22_RS16820	COG2155	Conserved Protein
GZ22_RS16825	COG0166	Belongs to the GPI family
GZ22_RS16830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GZ22_RS16850	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GZ22_RS16855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GZ22_RS16860	COG2050	protein possibly involved in aromatic compounds catabolism
GZ22_RS16865	COG1575	Belongs to the MenA family. Type 1 subfamily
GZ22_RS16870	COG1169	isochorismate synthase
GZ22_RS16875	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GZ22_RS16880	COG0596	Alpha beta hydrolase
GZ22_RS16885	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GZ22_RS16890	COG0318	PFAM AMP-dependent synthetase and ligase
GZ22_RS16895	COG4948	Mandelate Racemase Muconate Lactonizing
GZ22_RS16915	COG0494	nUDIX hydrolase
GZ22_RS16925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GZ22_RS16930	COG0367	asparagine synthase
GZ22_RS16935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GZ22_RS16945	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GZ22_RS16950	COG1744	ABC transporter substrate-binding protein PnrA-like
GZ22_RS16955	COG0840	transmembrane signaling receptor activity
GZ22_RS16960	COG0495	leucyl-tRNA aminoacylation
GZ22_RS16965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZ22_RS16985	COG1285	pathogenesis
GZ22_RS16995	COG3880	PFAM UvrB UvrC protein
GZ22_RS17000	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GZ22_RS17005	COG0542	response to heat
GZ22_RS17010	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GZ22_RS17015	COG4956	integral membrane protein (PIN domain superfamily)
GZ22_RS17020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GZ22_RS17025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GZ22_RS17030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZ22_RS17040	COG1045	serine acetyltransferase
GZ22_RS17045	COG0215	cysteine-tRNA ligase activity
GZ22_RS17055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZ22_RS17060	COG3688	RNA-binding protein containing a PIN domain
GZ22_RS17070	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GZ22_RS17075	COG0250	Participates in transcription elongation, termination and antitermination
GZ22_RS17080	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GZ22_RS17085	COG0081	regulation of translation
GZ22_RS17090	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GZ22_RS17095	COG0222	ribosome binding
GZ22_RS17100	COG2813	Specifically methylates the guanine in position
GZ22_RS17105	COG0085	RNA polymerase activity
GZ22_RS17110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GZ22_RS17115	COG1358	cellular component organization or biogenesis
GZ22_RS17120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GZ22_RS17125	COG0049	tRNA binding
GZ22_RS17130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GZ22_RS17135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GZ22_RS17145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GZ22_RS17150	COG0088	Forms part of the polypeptide exit tunnel
GZ22_RS17155	COG0089	rRNA binding
GZ22_RS17160	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GZ22_RS17165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GZ22_RS17170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GZ22_RS17175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GZ22_RS17180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GZ22_RS17185	COG0255	Belongs to the universal ribosomal protein uL29 family
GZ22_RS17190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GZ22_RS17195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GZ22_RS17200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GZ22_RS17205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GZ22_RS17210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GZ22_RS17215	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GZ22_RS17220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GZ22_RS17230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GZ22_RS17235	COG1841	ribosomal large subunit assembly
GZ22_RS17240	COG0200	Binds to the 23S rRNA
GZ22_RS17245	COG0201	protein transport
GZ22_RS17250	COG0563	adenylate kinase activity
GZ22_RS17260	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GZ22_RS17265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GZ22_RS17270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GZ22_RS17280	COG0202	RNA polymerase activity
GZ22_RS17285	COG0203	ribosomal protein L17
GZ22_RS17290	COG1122	ATPase activity
GZ22_RS17295	COG1122	ATPase activity
GZ22_RS17300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GZ22_RS17305	COG0101	tRNA pseudouridine synthase activity
GZ22_RS17310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GZ22_RS17315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GZ22_RS17340	COG0584	glycerophosphoryl diester phosphodiesterase
GZ22_RS17375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GZ22_RS17400	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZ22_RS17405	COG0489	protein tyrosine kinase activity
GZ22_RS17420	COG0726	polysaccharide deacetylase
GZ22_RS17425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GZ22_RS17500	COG3402	PFAM membrane-flanked domain
GZ22_RS17550	COG3409	Peptidoglycan-binding domain 1 protein
GZ22_RS17630	COG0741	lytic transglycosylase activity
GZ22_RS17630	COG0791	NLP P60 protein
GZ22_RS17725	COG1396	sequence-specific DNA binding
GZ22_RS17825	COG1192	Involved in chromosome partitioning
GZ22_RS17940	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GZ22_RS17950	COG3706	GGDEF domain
GZ22_RS17970	COG2267	carboxylic ester hydrolase activity
GZ22_RS17975	COG5002	protein histidine kinase activity
GZ22_RS17980	COG4469	Competence protein
GZ22_RS17985	COG3773	Cell wall hydrolase
GZ22_RS18010	COG0142	geranyltranstransferase activity
GZ22_RS18055	COG5444	nuclease activity
GZ22_RS18075	COG1309	transcriptional regulator
GZ22_RS18080	COG1404	Belongs to the peptidase S8 family
GZ22_RS18090	COG4193	domain, Protein
GZ22_RS18100	COG0463	Glycosyl transferase, family 2
GZ22_RS18105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZ22_RS18160	COG2376	Dihydroxyacetone kinase
GZ22_RS18180	COG2197	response regulator
GZ22_RS18195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GZ22_RS18220	COG0626	cystathionine gamma-synthase activity
GZ22_RS18285	COG3279	Response regulator of the LytR AlgR family
GZ22_RS18295	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GZ22_RS18295	COG1918	ferrous iron import across plasma membrane
GZ22_RS18300	COG5444	nuclease activity
GZ22_RS18335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GZ22_RS18350	COG1396	sequence-specific DNA binding