locus-tag	class	description
ACIPR4_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACIPR4_RS00025	COG1193	negative regulation of DNA recombination
ACIPR4_RS00030	COG0667	Aldo Keto reductase
ACIPR4_RS00040	COG0113	porphobilinogen synthase activity
ACIPR4_RS00060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIPR4_RS00065	COG1733	regulation of RNA biosynthetic process
ACIPR4_RS00090	COG0702	epimerase
ACIPR4_RS00095	COG1733	regulation of RNA biosynthetic process
ACIPR4_RS00130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACIPR4_RS00135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACIPR4_RS00145	COG0656	L-ascorbic acid biosynthetic process
ACIPR4_RS00160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIPR4_RS00170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACIPR4_RS00200	COG2140	Oxalate decarboxylase
ACIPR4_RS00205	COG0386	Belongs to the glutathione peroxidase family
ACIPR4_RS00210	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACIPR4_RS00225	COG0667	Aldo Keto reductase
ACIPR4_RS00240	COG0577	efflux transmembrane transporter activity
ACIPR4_RS00245	COG0577	efflux transmembrane transporter activity
ACIPR4_RS00290	COG0583	DNA-binding transcription factor activity
ACIPR4_RS00325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIPR4_RS00350	COG1082	Xylose isomerase domain protein TIM barrel
ACIPR4_RS00370	COG0321	lipoyl(octanoyl) transferase activity
ACIPR4_RS00375	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACIPR4_RS00400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACIPR4_RS00405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACIPR4_RS00410	COG2826	transposase and inactivated derivatives, IS30 family
ACIPR4_RS00515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACIPR4_RS00525	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS00540	COG2197	response regulator
ACIPR4_RS00620	COG0582	viral genome integration into host DNA
ACIPR4_RS00655	COG0316	Belongs to the HesB IscA family
ACIPR4_RS00660	COG0577	efflux transmembrane transporter activity
ACIPR4_RS00660	COG1136	(ABC) transporter
ACIPR4_RS00665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIPR4_RS00675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACIPR4_RS00685	COG0443	Heat shock 70 kDa protein
ACIPR4_RS00700	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACIPR4_RS00705	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ACIPR4_RS00715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACIPR4_RS00735	COG2814	Major facilitator Superfamily
ACIPR4_RS00745	COG1764	response to oxidative stress
ACIPR4_RS00765	COG0612	Peptidase, M16
ACIPR4_RS00810	COG2081	HI0933 family
ACIPR4_RS00855	COG4302	ethanolamine ammonia-lyase activity
ACIPR4_RS00860	COG4303	Ethanolamine ammonia lyase large subunit
ACIPR4_RS00875	COG3511	phospholipase C
ACIPR4_RS00885	COG2223	nitrite transmembrane transporter activity
ACIPR4_RS00920	COG0640	Transcriptional regulator
ACIPR4_RS01015	COG1278	Cold shock
ACIPR4_RS01050	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACIPR4_RS01055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACIPR4_RS01060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACIPR4_RS01065	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACIPR4_RS01080	COG0477	Major facilitator Superfamily
ACIPR4_RS01120	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS01155	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ACIPR4_RS01160	COG0405	Gamma-glutamyltransferase
ACIPR4_RS01180	COG0017	Asparaginyl-tRNA synthetase
ACIPR4_RS01235	COG0012	GTP binding
ACIPR4_RS01260	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACIPR4_RS01275	COG2134	cdp-diacylglycerol pyrophosphatase
ACIPR4_RS01285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACIPR4_RS01310	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACIPR4_RS01320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACIPR4_RS01335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACIPR4_RS01340	COG0540	Belongs to the ATCase OTCase family
ACIPR4_RS01350	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ACIPR4_RS01370	COG0789	Transcriptional regulator
ACIPR4_RS01380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACIPR4_RS01395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACIPR4_RS01400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACIPR4_RS01455	COG4251	negative regulation of phosphorylation
ACIPR4_RS01460	COG0784	Response regulator, receiver
ACIPR4_RS01465	COG4191	Histidine kinase
ACIPR4_RS01535	COG0429	hydrolase of the alpha beta-hydrolase fold
ACIPR4_RS01560	COG3706	GGDEF domain
ACIPR4_RS01565	COG2814	Major facilitator Superfamily
ACIPR4_RS01575	COG0416	fatty acid biosynthetic process
ACIPR4_RS01605	COG0537	adenosine 5'-monophosphoramidase activity
ACIPR4_RS01610	COG0501	Belongs to the peptidase M48B family
ACIPR4_RS01655	COG3387	PFAM Glycoside hydrolase 15-related
ACIPR4_RS01675	COG0784	Response regulator, receiver
ACIPR4_RS01680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACIPR4_RS01700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ACIPR4_RS01715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACIPR4_RS01740	COG0124	histidyl-tRNA synthetase
ACIPR4_RS01770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIPR4_RS01780	COG0546	phosphoglycolate phosphatase activity
ACIPR4_RS01780	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACIPR4_RS01785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACIPR4_RS01795	COG0531	amino acid
ACIPR4_RS01800	COG0165	Argininosuccinate lyase
ACIPR4_RS01810	COG1940	carbohydrate kinase activity
ACIPR4_RS01825	COG3383	formate dehydrogenase (NAD+) activity
ACIPR4_RS01845	COG0564	pseudouridine synthase activity
ACIPR4_RS01850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACIPR4_RS01855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACIPR4_RS01860	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ACIPR4_RS01895	COG0081	regulation of translation
ACIPR4_RS01900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACIPR4_RS01905	COG0222	ribosome binding
ACIPR4_RS01915	COG0085	RNA polymerase activity
ACIPR4_RS01920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACIPR4_RS01940	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ACIPR4_RS01955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACIPR4_RS02015	COG1472	Belongs to the glycosyl hydrolase 3 family
ACIPR4_RS02030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACIPR4_RS02030	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ACIPR4_RS02035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACIPR4_RS02065	COG3537	Alpha-1,2-mannosidase
ACIPR4_RS02075	COG0562	UDP-galactopyranose mutase
ACIPR4_RS02110	COG1131	(ABC) transporter
ACIPR4_RS02120	COG1505	serine-type exopeptidase activity
ACIPR4_RS02130	COG0251	oxidation-reduction process
ACIPR4_RS02140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACIPR4_RS02150	COG1335	isochorismatase
ACIPR4_RS02170	COG3547	Transposase (IS116 IS110 IS902 family)
ACIPR4_RS02180	COG0577	efflux transmembrane transporter activity
ACIPR4_RS02180	COG1136	(ABC) transporter
ACIPR4_RS02185	COG0251	oxidation-reduction process
ACIPR4_RS02230	COG1595	DNA-templated transcription, initiation
ACIPR4_RS02240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACIPR4_RS02245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACIPR4_RS02265	COG0667	Aldo Keto reductase
ACIPR4_RS02295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACIPR4_RS02330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACIPR4_RS02345	COG3733	amine oxidase
ACIPR4_RS02355	COG2814	Major facilitator Superfamily
ACIPR4_RS02375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACIPR4_RS02380	COG2211	Major facilitator Superfamily
ACIPR4_RS02385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ACIPR4_RS02410	COG0058	SHG alpha-glucan phosphorylase activity
ACIPR4_RS02415	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ACIPR4_RS02420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACIPR4_RS02445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACIPR4_RS02475	COG0577	efflux transmembrane transporter activity
ACIPR4_RS02485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACIPR4_RS02490	COG0237	dephospho-CoA kinase activity
ACIPR4_RS02495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACIPR4_RS02500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACIPR4_RS02505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACIPR4_RS02510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACIPR4_RS02515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACIPR4_RS02530	COG0698	ribose 5-phosphate isomerase
ACIPR4_RS02535	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS02545	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ACIPR4_RS02550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACIPR4_RS02555	COG0363	glucosamine-6-phosphate deaminase activity
ACIPR4_RS02560	COG0837	glucose binding
ACIPR4_RS02565	COG0308	aminopeptidase N
ACIPR4_RS02570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACIPR4_RS02575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACIPR4_RS02585	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACIPR4_RS02605	COG0525	valine-tRNA ligase activity
ACIPR4_RS02615	COG2382	esterase
ACIPR4_RS02615	COG3693	PFAM glycoside hydrolase, family 10
ACIPR4_RS02625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACIPR4_RS02630	COG0322	excinuclease ABC activity
ACIPR4_RS02635	COG0312	modulator of DNA gyrase
ACIPR4_RS02640	COG0312	modulator of DNA gyrase
ACIPR4_RS02645	COG2318	DinB family
ACIPR4_RS02660	COG0254	rRNA binding
ACIPR4_RS02670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACIPR4_RS02685	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACIPR4_RS02705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACIPR4_RS02710	COG0754	glutathionylspermidine amidase activity
ACIPR4_RS02720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACIPR4_RS02760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACIPR4_RS02765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACIPR4_RS02770	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACIPR4_RS02780	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS02785	COG1309	transcriptional regulator
ACIPR4_RS02795	COG0784	Response regulator, receiver
ACIPR4_RS02795	COG2205	protein histidine kinase activity
ACIPR4_RS02800	COG0577	efflux transmembrane transporter activity
ACIPR4_RS02800	COG1136	(ABC) transporter
ACIPR4_RS02805	COG0667	Aldo Keto reductase
ACIPR4_RS02810	COG1309	transcriptional regulator
ACIPR4_RS02840	COG1216	Glycosyl transferase, family 2
ACIPR4_RS02840	COG0463	Glycosyl transferase, family 2
ACIPR4_RS02845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACIPR4_RS02855	COG2204	response regulator
ACIPR4_RS02860	COG2204	response regulator
ACIPR4_RS02865	COG0438	transferase activity, transferring glycosyl groups
ACIPR4_RS02865	COG0297	glycogen (starch) synthase activity
ACIPR4_RS02880	COG0438	transferase activity, transferring glycosyl groups
ACIPR4_RS02885	COG1215	transferase activity, transferring glycosyl groups
ACIPR4_RS02890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACIPR4_RS02895	COG0489	protein tyrosine kinase activity
ACIPR4_RS02900	COG3409	Peptidoglycan-binding domain 1 protein
ACIPR4_RS02900	COG3267	Type II secretory pathway component ExeA
ACIPR4_RS02905	COG3206	protein involved in exopolysaccharide biosynthesis
ACIPR4_RS02905	COG0489	protein tyrosine kinase activity
ACIPR4_RS02915	COG1596	polysaccharide export
ACIPR4_RS02960	COG0793	Belongs to the peptidase S41A family
ACIPR4_RS02965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIPR4_RS02970	COG3481	metal-dependent phosphohydrolase, HD sub domain
ACIPR4_RS02985	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACIPR4_RS02990	COG0242	peptide deformylase activity
ACIPR4_RS02995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACIPR4_RS03000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACIPR4_RS03000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACIPR4_RS03005	COG0515	serine threonine protein kinase
ACIPR4_RS03005	COG2815	serine threonine protein kinase
ACIPR4_RS03010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACIPR4_RS03015	COG2226	methyltransferase
ACIPR4_RS03020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACIPR4_RS03035	COG0805	protein transport
ACIPR4_RS03040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACIPR4_RS03050	COG1272	protein, Hemolysin III
ACIPR4_RS03055	COG0657	acetylesterase activity
ACIPR4_RS03060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACIPR4_RS03080	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACIPR4_RS03095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACIPR4_RS03100	COG1278	Cold shock
ACIPR4_RS03140	COG3119	arylsulfatase activity
ACIPR4_RS03140	COG3408	Glycogen debranching enzyme
ACIPR4_RS03180	COG2855	membrane
ACIPR4_RS03220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ACIPR4_RS03230	COG0572	uridine kinase
ACIPR4_RS03255	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACIPR4_RS03270	COG1899	peptidyl-lysine modification to peptidyl-hypusine
ACIPR4_RS03275	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ACIPR4_RS03280	COG0295	cytidine deaminase activity
ACIPR4_RS03285	COG1201	RNA secondary structure unwinding
ACIPR4_RS03290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACIPR4_RS03300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACIPR4_RS03305	COG0442	prolyl-tRNA aminoacylation
ACIPR4_RS03320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACIPR4_RS03330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACIPR4_RS03345	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACIPR4_RS03350	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACIPR4_RS03360	COG0037	tRNA processing
ACIPR4_RS03365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACIPR4_RS03380	COG1396	sequence-specific DNA binding
ACIPR4_RS03390	COG3706	GGDEF domain
ACIPR4_RS03390	COG4251	negative regulation of phosphorylation
ACIPR4_RS03390	COG5001	Diguanylate cyclase
ACIPR4_RS03390	COG2203	Gaf domain
ACIPR4_RS03400	COG0577	efflux transmembrane transporter activity
ACIPR4_RS03400	COG1136	(ABC) transporter
ACIPR4_RS03440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACIPR4_RS03475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACIPR4_RS03490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACIPR4_RS03500	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACIPR4_RS03510	COG0793	Belongs to the peptidase S41A family
ACIPR4_RS03515	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACIPR4_RS03520	COG0196	riboflavin kinase activity
ACIPR4_RS03525	COG0321	lipoyl(octanoyl) transferase activity
ACIPR4_RS03525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACIPR4_RS03535	COG0354	folic acid binding
ACIPR4_RS03545	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ACIPR4_RS03560	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACIPR4_RS03565	COG1619	proteins homologs of microcin C7 resistance protein MccF
ACIPR4_RS03570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACIPR4_RS03585	COG0330	HflC and HflK could
ACIPR4_RS03620	COG1063	alcohol dehydrogenase
ACIPR4_RS03625	COG0156	8-amino-7-oxononanoate synthase activity
ACIPR4_RS03645	COG3590	peptidase
ACIPR4_RS03665	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACIPR4_RS03675	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS03735	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS03755	COG0659	secondary active sulfate transmembrane transporter activity
ACIPR4_RS03775	COG3781	membrane
ACIPR4_RS03800	COG1136	(ABC) transporter
ACIPR4_RS03810	COG0736	holo-[acyl-carrier-protein] synthase activity
ACIPR4_RS03825	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ACIPR4_RS03835	COG1187	pseudouridine synthase activity
ACIPR4_RS03850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACIPR4_RS03870	COG1216	Glycosyl transferase, family 2
ACIPR4_RS03875	COG0513	Belongs to the DEAD box helicase family
ACIPR4_RS03910	COG2204	response regulator
ACIPR4_RS03955	COG1285	pathogenesis
ACIPR4_RS03965	COG1607	acyl-coa hydrolase
ACIPR4_RS03970	COG0489	protein tyrosine kinase activity
ACIPR4_RS03980	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACIPR4_RS03985	COG0484	heat shock protein binding
ACIPR4_RS03990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACIPR4_RS03995	COG1760	l-serine dehydratase
ACIPR4_RS04005	COG0606	chelatase, subunit chli
ACIPR4_RS04015	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACIPR4_RS04020	COG2199	diguanylate cyclase activity
ACIPR4_RS04020	COG2202	Pas domain
ACIPR4_RS04020	COG2200	EAL domain
ACIPR4_RS04025	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ACIPR4_RS04040	COG0038	chloride channel
ACIPR4_RS04090	COG1940	carbohydrate kinase activity
ACIPR4_RS04095	COG1472	Belongs to the glycosyl hydrolase 3 family
ACIPR4_RS04110	COG2271	Major facilitator Superfamily
ACIPR4_RS04115	COG4585	Histidine kinase
ACIPR4_RS04120	COG2197	response regulator
ACIPR4_RS04130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACIPR4_RS04150	COG3964	amidohydrolase
ACIPR4_RS04180	COG2197	response regulator
ACIPR4_RS04185	COG2197	response regulator
ACIPR4_RS04190	COG2885	chlorophyll binding
ACIPR4_RS04195	COG4221	oxidoreductase activity
ACIPR4_RS04210	COG1968	undecaprenyl-diphosphatase activity
ACIPR4_RS04230	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ACIPR4_RS04240	COG2171	N-acyltransferase activity
ACIPR4_RS04245	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ACIPR4_RS04265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACIPR4_RS04280	COG2309	aminopeptidase activity
ACIPR4_RS04290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACIPR4_RS04295	COG0527	aspartate kinase activity
ACIPR4_RS04315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACIPR4_RS04325	COG0741	lytic transglycosylase activity
ACIPR4_RS04330	COG0561	phosphatase activity
ACIPR4_RS04335	COG0697	spore germination
ACIPR4_RS04350	COG1792	Involved in formation and maintenance of cell shape
ACIPR4_RS04365	COG5000	phosphorelay sensor kinase activity
ACIPR4_RS04370	COG2204	response regulator
ACIPR4_RS04375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACIPR4_RS04385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACIPR4_RS04405	COG0268	Binds directly to 16S ribosomal RNA
ACIPR4_RS04410	COG0768	penicillin binding
ACIPR4_RS04415	COG0772	Belongs to the SEDS family
ACIPR4_RS04425	COG1530	ribonuclease E activity
ACIPR4_RS04425	COG1530	ribonuclease E activity
ACIPR4_RS04440	COG0006	proline dipeptidase activity
ACIPR4_RS04450	COG0463	Glycosyl transferase, family 2
ACIPR4_RS04455	COG0657	acetylesterase activity
ACIPR4_RS04460	COG0644	oxidoreductase
ACIPR4_RS04480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACIPR4_RS04485	COG0629	single-stranded DNA binding
ACIPR4_RS04500	COG0463	Glycosyl transferase, family 2
ACIPR4_RS04505	COG1496	oxidoreductase activity
ACIPR4_RS04515	COG2322	membrane
ACIPR4_RS04520	COG0109	protoheme IX farnesyltransferase activity
ACIPR4_RS04525	COG0628	permease
ACIPR4_RS04530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACIPR4_RS04540	COG1595	DNA-templated transcription, initiation
ACIPR4_RS04545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACIPR4_RS04550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACIPR4_RS04565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACIPR4_RS04570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACIPR4_RS04575	COG0772	Belongs to the SEDS family
ACIPR4_RS04580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACIPR4_RS04595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACIPR4_RS04600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACIPR4_RS04615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACIPR4_RS04620	COG0768	penicillin binding
ACIPR4_RS04625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACIPR4_RS04625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACIPR4_RS04630	COG0802	atpase or kinase
ACIPR4_RS04635	COG2267	carboxylic ester hydrolase activity
ACIPR4_RS04640	COG4977	sequence-specific DNA binding
ACIPR4_RS04650	COG0783	Belongs to the Dps family
ACIPR4_RS04655	COG0488	(ABC) transporter
ACIPR4_RS04665	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACIPR4_RS04675	COG0667	Aldo Keto reductase
ACIPR4_RS04715	COG0456	acetyltransferase
ACIPR4_RS04720	COG0688	phosphatidylethanolamine metabolic process
ACIPR4_RS04725	COG1183	phosphatidylcholine synthase activity
ACIPR4_RS04750	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACIPR4_RS04760	COG0167	dihydroorotate dehydrogenase activity
ACIPR4_RS04770	COG0138	bifunctional purine biosynthesis protein purh
ACIPR4_RS04775	COG0457	Tetratricopeptide repeat
ACIPR4_RS04780	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACIPR4_RS04810	COG0492	ferredoxin-NADP+ reductase activity
ACIPR4_RS04815	COG3852	Histidine kinase
ACIPR4_RS04850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACIPR4_RS04855	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACIPR4_RS04865	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIPR4_RS04875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACIPR4_RS04885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACIPR4_RS04890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACIPR4_RS04895	COG0740	serine-type endopeptidase activity
ACIPR4_RS04900	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACIPR4_RS04910	COG1573	uracil-dna glycosylase
ACIPR4_RS04920	COG0542	response to heat
ACIPR4_RS04925	COG1136	(ABC) transporter
ACIPR4_RS04935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACIPR4_RS04940	COG0347	Belongs to the P(II) protein family
ACIPR4_RS04945	COG0004	ammonium transporteR
ACIPR4_RS04955	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIPR4_RS04970	COG3250	beta-galactosidase activity
ACIPR4_RS04985	COG0538	isocitrate dehydrogenase activity
ACIPR4_RS04990	COG0579	oxidoreductase
ACIPR4_RS05035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACIPR4_RS05040	COG1053	succinate dehydrogenase
ACIPR4_RS05045	COG2009	succinate dehydrogenase
ACIPR4_RS05060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACIPR4_RS05065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACIPR4_RS05100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIPR4_RS05105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACIPR4_RS05145	COG1846	Transcriptional regulator
ACIPR4_RS05150	COG0346	lactoylglutathione lyase activity
ACIPR4_RS05185	COG3850	Histidine kinase
ACIPR4_RS05185	COG5002	protein histidine kinase activity
ACIPR4_RS05200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIPR4_RS05220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACIPR4_RS05225	COG0667	Aldo Keto reductase
ACIPR4_RS05265	COG4702	Belongs to the UPF0303 family
ACIPR4_RS05270	COG0247	lactate metabolic process
ACIPR4_RS05270	COG0277	FAD linked oxidase domain protein
ACIPR4_RS05275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACIPR4_RS05285	COG2271	Major facilitator Superfamily
ACIPR4_RS05290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACIPR4_RS05295	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS05300	COG1063	alcohol dehydrogenase
ACIPR4_RS05320	COG0302	gtp cyclohydrolase
ACIPR4_RS05325	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACIPR4_RS05335	COG1136	(ABC) transporter
ACIPR4_RS05335	COG0577	efflux transmembrane transporter activity
ACIPR4_RS05340	COG1136	(ABC) transporter
ACIPR4_RS05340	COG0577	efflux transmembrane transporter activity
ACIPR4_RS05345	COG1733	regulation of RNA biosynthetic process
ACIPR4_RS05355	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACIPR4_RS05470	COG0823	Involved in the tonB-independent uptake of proteins
ACIPR4_RS05510	COG0747	negative chemotaxis
ACIPR4_RS05520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACIPR4_RS05550	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACIPR4_RS05555	COG0181	hydroxymethylbilane synthase activity
ACIPR4_RS05565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACIPR4_RS05570	COG3253	May function as heme-dependent peroxidase
ACIPR4_RS05575	COG0586	Pfam SNARE associated Golgi protein
ACIPR4_RS05580	COG0701	Predicted permease
ACIPR4_RS05585	COG1360	Flagellar Motor Protein
ACIPR4_RS05590	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACIPR4_RS05595	COG1582	Flagellar protein (FlbD)
ACIPR4_RS05600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACIPR4_RS05605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ACIPR4_RS05630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACIPR4_RS05640	COG0028	Belongs to the TPP enzyme family
ACIPR4_RS05645	COG0129	dihydroxy-acid dehydratase activity
ACIPR4_RS05655	COG0066	3-isopropylmalate dehydratase activity
ACIPR4_RS05660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACIPR4_RS05670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACIPR4_RS05675	COG0583	DNA-binding transcription factor activity
ACIPR4_RS05710	COG2323	membrane
ACIPR4_RS05720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACIPR4_RS05735	COG1301	dicarboxylic acid transport
ACIPR4_RS05740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACIPR4_RS05750	COG4774	siderophore transport
ACIPR4_RS05755	COG3128	pkhd-type hydroxylase
ACIPR4_RS05770	COG2001	Belongs to the MraZ family
ACIPR4_RS05775	COG0275	rRNA processing
ACIPR4_RS05790	COG0730	response to heat
ACIPR4_RS05795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACIPR4_RS05805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIPR4_RS05820	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACIPR4_RS05835	COG0077	Prephenate dehydratase
ACIPR4_RS05835	COG1605	Chorismate mutase
ACIPR4_RS05840	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACIPR4_RS05850	COG0314	molybdopterin synthase activity
ACIPR4_RS05860	COG0483	inositol monophosphate 1-phosphatase activity
ACIPR4_RS05875	COG1381	Involved in DNA repair and RecF pathway recombination
ACIPR4_RS05880	COG1597	lipid kinase activity
ACIPR4_RS05900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACIPR4_RS05920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACIPR4_RS05925	COG0083	homoserine kinase activity
ACIPR4_RS05930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACIPR4_RS05970	COG3325	Belongs to the glycosyl hydrolase 18 family
ACIPR4_RS05970	COG3469	chitinase activity
ACIPR4_RS06000	COG0667	Aldo Keto reductase
ACIPR4_RS06020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIPR4_RS06080	COG1012	belongs to the aldehyde dehydrogenase family
ACIPR4_RS06090	COG2197	response regulator
ACIPR4_RS06115	COG2885	chlorophyll binding
ACIPR4_RS06190	COG4585	Histidine kinase
ACIPR4_RS06195	COG2197	response regulator
ACIPR4_RS06215	COG3119	arylsulfatase activity
ACIPR4_RS06220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIPR4_RS06225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACIPR4_RS06235	COG0512	Glutamine amidotransferase of anthranilate synthase
ACIPR4_RS06245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACIPR4_RS06250	COG2267	carboxylic ester hydrolase activity
ACIPR4_RS06255	COG1254	Belongs to the acylphosphatase family
ACIPR4_RS06260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACIPR4_RS06265	COG1064	alcohol dehydrogenase
ACIPR4_RS06290	COG1570	exodeoxyribonuclease VII activity
ACIPR4_RS06295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACIPR4_RS06325	COG3706	GGDEF domain
ACIPR4_RS06355	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACIPR4_RS06370	COG0577	efflux transmembrane transporter activity
ACIPR4_RS06370	COG1136	(ABC) transporter
ACIPR4_RS06375	COG1695	Transcriptional regulator
ACIPR4_RS06380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACIPR4_RS06385	COG3507	Belongs to the glycosyl hydrolase 43 family
ACIPR4_RS06395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACIPR4_RS06405	COG2860	membrane
ACIPR4_RS06425	COG1027	Aspartate ammonia-lyase
ACIPR4_RS06445	COG0492	ferredoxin-NADP+ reductase activity
ACIPR4_RS06465	COG1131	(ABC) transporter
ACIPR4_RS06470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIPR4_RS06490	COG3537	Alpha-1,2-mannosidase
ACIPR4_RS06495	COG0752	glycyl-tRNA synthetase alpha subunit
ACIPR4_RS06500	COG0751	glycine-tRNA ligase activity
ACIPR4_RS06520	COG1137	ATPase activity
ACIPR4_RS06535	COG1660	Displays ATPase and GTPase activities
ACIPR4_RS06540	COG1132	(ABC) transporter
ACIPR4_RS06545	COG1561	YicC-like family, N-terminal region
ACIPR4_RS06550	COG0194	GDP metabolic process
ACIPR4_RS06555	COG1758	RNA polymerase activity
ACIPR4_RS06560	COG1573	uracil-dna glycosylase
ACIPR4_RS06565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACIPR4_RS06570	COG0776	regulation of translation
ACIPR4_RS06575	COG0717	Belongs to the dCTP deaminase family
ACIPR4_RS06590	COG1560	Kdo2-lipid A biosynthetic process
ACIPR4_RS06595	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIPR4_RS06610	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ACIPR4_RS06610	COG0646	methionine synthase
ACIPR4_RS06615	COG1722	exodeoxyribonuclease VII activity
ACIPR4_RS06620	COG0142	geranyltranstransferase activity
ACIPR4_RS06625	COG1666	GTP binding
ACIPR4_RS06630	COG0084	hydrolase, TatD family'
ACIPR4_RS06640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACIPR4_RS06640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACIPR4_RS06650	COG5520	Belongs to the glycosyl hydrolase 30 family
ACIPR4_RS06655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACIPR4_RS06670	COG1940	carbohydrate kinase activity
ACIPR4_RS06680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACIPR4_RS06690	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ACIPR4_RS06700	COG0109	protoheme IX farnesyltransferase activity
ACIPR4_RS06700	COG1612	heme a metabolic process
ACIPR4_RS06705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACIPR4_RS06715	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACIPR4_RS06735	COG0681	Belongs to the peptidase S26 family
ACIPR4_RS06745	COG0149	triose-phosphate isomerase activity
ACIPR4_RS06750	COG0126	phosphoglycerate kinase activity
ACIPR4_RS06760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACIPR4_RS06770	COG1125	glycine betaine transport
ACIPR4_RS06770	COG0517	IMP dehydrogenase activity
ACIPR4_RS06810	COG2165	general secretion pathway protein
ACIPR4_RS06815	COG1595	DNA-templated transcription, initiation
ACIPR4_RS06825	COG1054	Belongs to the UPF0176 family
ACIPR4_RS06835	COG1136	(ABC) transporter
ACIPR4_RS06835	COG0577	efflux transmembrane transporter activity
ACIPR4_RS06840	COG2267	carboxylic ester hydrolase activity
ACIPR4_RS06880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACIPR4_RS06915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACIPR4_RS06920	COG1917	Cupin 2, conserved barrel domain protein
ACIPR4_RS06920	COG2207	Transcriptional regulator
ACIPR4_RS06925	COG0612	Peptidase, M16
ACIPR4_RS06930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACIPR4_RS06935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ACIPR4_RS06950	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACIPR4_RS06950	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACIPR4_RS06970	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ACIPR4_RS06975	COG0457	Tetratricopeptide repeat
ACIPR4_RS07000	COG0018	arginyl-trna synthetase
ACIPR4_RS07005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACIPR4_RS07010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACIPR4_RS07015	COG1450	Type ii and iii secretion system protein
ACIPR4_RS07040	COG3956	TIGRFAM MazG family protein
ACIPR4_RS07050	COG4948	Mandelate Racemase Muconate Lactonizing
ACIPR4_RS07075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACIPR4_RS07090	COG1832	CoA-binding protein
ACIPR4_RS07115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACIPR4_RS07120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACIPR4_RS07145	COG1595	DNA-templated transcription, initiation
ACIPR4_RS07150	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ACIPR4_RS07155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACIPR4_RS07165	COG1136	(ABC) transporter
ACIPR4_RS07165	COG0577	efflux transmembrane transporter activity
ACIPR4_RS07175	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS07185	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ACIPR4_RS07190	COG1349	DNA-binding transcription factor activity
ACIPR4_RS07195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACIPR4_RS07215	COG2814	Major facilitator Superfamily
ACIPR4_RS07225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACIPR4_RS07235	COG0577	efflux transmembrane transporter activity
ACIPR4_RS07235	COG1136	(ABC) transporter
ACIPR4_RS07285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACIPR4_RS07290	COG1085	galactose-1-phosphate uridylyltransferase
ACIPR4_RS07300	COG0247	lactate metabolic process
ACIPR4_RS07305	COG1139	Iron-sulfur cluster binding protein
ACIPR4_RS07310	COG1556	Lactate utilization protein
ACIPR4_RS07325	COG1476	TRANSCRIPTIONal
ACIPR4_RS07330	COG4952	isomerase
ACIPR4_RS07340	COG3347	Dehydrogenase
ACIPR4_RS07340	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS07345	COG1070	Carbohydrate kinase
ACIPR4_RS07375	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACIPR4_RS07380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACIPR4_RS07395	COG0463	Glycosyl transferase, family 2
ACIPR4_RS07405	COG0657	acetylesterase activity
ACIPR4_RS07405	COG2755	lipolytic protein G-D-S-L family
ACIPR4_RS07425	COG0501	Belongs to the peptidase M48B family
ACIPR4_RS07465	COG2815	serine threonine protein kinase
ACIPR4_RS07465	COG0515	serine threonine protein kinase
ACIPR4_RS07490	COG0148	phosphopyruvate hydratase activity
ACIPR4_RS07495	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACIPR4_RS07505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACIPR4_RS07510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACIPR4_RS07515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACIPR4_RS07560	COG2514	catechol 2,3-dioxygenase activity
ACIPR4_RS07565	COG0217	transcriptional regulatory protein
ACIPR4_RS07585	COG2826	transposase and inactivated derivatives, IS30 family
ACIPR4_RS07595	COG1595	DNA-templated transcription, initiation
ACIPR4_RS07600	COG1196	nuclear chromosome segregation
ACIPR4_RS07600	COG0739	heme binding
ACIPR4_RS07600	COG0741	lytic transglycosylase activity
ACIPR4_RS07605	COG0577	efflux transmembrane transporter activity
ACIPR4_RS07605	COG1136	(ABC) transporter
ACIPR4_RS07610	COG0577	efflux transmembrane transporter activity
ACIPR4_RS07650	COG2084	Dehydrogenase
ACIPR4_RS07655	COG1620	l-lactate permease
ACIPR4_RS07660	COG2186	Transcriptional regulator
ACIPR4_RS07665	COG0745	RESPONSE REGULATOR receiver
ACIPR4_RS07670	COG0642	Histidine kinase
ACIPR4_RS07725	COG1609	Transcriptional regulator
ACIPR4_RS07730	COG0457	Tetratricopeptide repeat
ACIPR4_RS07735	COG2814	Major facilitator Superfamily
ACIPR4_RS07765	COG3279	Response regulator of the LytR AlgR family
ACIPR4_RS07785	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ACIPR4_RS07800	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACIPR4_RS07805	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACIPR4_RS07810	COG0477	Major facilitator Superfamily
ACIPR4_RS07835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACIPR4_RS07845	COG3119	arylsulfatase activity
ACIPR4_RS07855	COG3119	arylsulfatase activity
ACIPR4_RS07895	COG3275	phosphorelay sensor kinase activity
ACIPR4_RS07900	COG3279	Response regulator of the LytR AlgR family
ACIPR4_RS07930	COG3119	arylsulfatase activity
ACIPR4_RS07945	COG0823	Involved in the tonB-independent uptake of proteins
ACIPR4_RS07955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACIPR4_RS07960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIPR4_RS07970	COG0587	DNA-directed DNA polymerase activity
ACIPR4_RS08045	COG0587	DNA-directed DNA polymerase activity
ACIPR4_RS08095	COG0596	Alpha beta hydrolase
ACIPR4_RS08140	COG0604	alcohol dehydrogenase
ACIPR4_RS08145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIPR4_RS08160	COG0383	alpha-mannosidase activity
ACIPR4_RS08175	COG3537	Alpha-1,2-mannosidase
ACIPR4_RS08210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACIPR4_RS08245	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ACIPR4_RS08250	COG1846	Transcriptional regulator
ACIPR4_RS08260	COG0667	Aldo Keto reductase
ACIPR4_RS08265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ACIPR4_RS08275	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACIPR4_RS08280	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ACIPR4_RS08295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACIPR4_RS08305	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACIPR4_RS08315	COG2201	protein-glutamate methylesterase activity
ACIPR4_RS08330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACIPR4_RS08335	COG1648	precorrin-2 dehydrogenase activity
ACIPR4_RS08335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACIPR4_RS08340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACIPR4_RS08355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACIPR4_RS08375	COG1904	glucuronate isomerase
ACIPR4_RS08380	COG3265	gluconokinase activity
ACIPR4_RS08385	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS08390	COG1691	(AIR) carboxylase
ACIPR4_RS08395	COG0251	oxidation-reduction process
ACIPR4_RS08400	COG1606	tRNA processing
ACIPR4_RS08405	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS08420	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ACIPR4_RS08425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACIPR4_RS08445	COG0383	alpha-mannosidase activity
ACIPR4_RS08450	COG3345	alpha-galactosidase
ACIPR4_RS08475	COG2706	6-phosphogluconolactonase activity
ACIPR4_RS08495	COG0235	Class ii aldolase
ACIPR4_RS08515	COG3940	Belongs to the glycosyl hydrolase 43 family
ACIPR4_RS08530	COG2755	lipolytic protein G-D-S-L family
ACIPR4_RS08540	COG2755	lipolytic protein G-D-S-L family
ACIPR4_RS08625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACIPR4_RS08650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACIPR4_RS08650	COG2857	Cytochrome c1
ACIPR4_RS08665	COG4585	Histidine kinase
ACIPR4_RS08670	COG2197	response regulator
ACIPR4_RS08685	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACIPR4_RS08690	COG0166	Belongs to the GPI family
ACIPR4_RS08720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACIPR4_RS08725	COG1295	ribonuclease BN
ACIPR4_RS08730	COG2208	phosphoserine phosphatase activity
ACIPR4_RS08730	COG2770	Histidine kinase
ACIPR4_RS08740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACIPR4_RS08750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ACIPR4_RS08775	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACIPR4_RS08795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ACIPR4_RS08810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACIPR4_RS08820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACIPR4_RS08840	COG0778	Nitroreductase
ACIPR4_RS08850	COG0163	prenyltransferase activity
ACIPR4_RS08865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACIPR4_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS08905	COG2957	Belongs to the agmatine deiminase family
ACIPR4_RS08920	COG1945	arginine decarboxylase activity
ACIPR4_RS08950	COG0556	nucleotide-excision repair
ACIPR4_RS08955	COG2311	Membrane
ACIPR4_RS08960	COG0477	Major facilitator Superfamily
ACIPR4_RS08965	COG0546	phosphoglycolate phosphatase activity
ACIPR4_RS08975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIPR4_RS08980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACIPR4_RS08985	COG0745	RESPONSE REGULATOR receiver
ACIPR4_RS09000	COG1815	bacterial-type flagellum-dependent cell motility
ACIPR4_RS09005	COG1558	bacterial-type flagellum-dependent cell motility
ACIPR4_RS09010	COG1677	Flagellar hook-basal body complex protein FliE
ACIPR4_RS09020	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACIPR4_RS09045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ACIPR4_RS09050	COG1749	Flagellar hook protein flgE
ACIPR4_RS09080	COG1684	flagellar biosynthetic protein fliR
ACIPR4_RS09085	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACIPR4_RS09090	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACIPR4_RS09095	COG1191	sigma factor activity
ACIPR4_RS09105	COG1776	CheC inhibitor of MCP methylation
ACIPR4_RS09105	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACIPR4_RS09110	COG4786	Flagellar basal body rod
ACIPR4_RS09125	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ACIPR4_RS09130	COG1706	bacterial-type flagellum-dependent cell motility
ACIPR4_RS09150	COG1256	bacterial-type flagellum assembly
ACIPR4_RS09150	COG4786	Flagellar basal body rod
ACIPR4_RS09165	COG2382	esterase
ACIPR4_RS09165	COG3507	Belongs to the glycosyl hydrolase 43 family
ACIPR4_RS09165	COG3693	PFAM glycoside hydrolase, family 10
ACIPR4_RS09175	COG1819	glycosyl
ACIPR4_RS09185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACIPR4_RS09190	COG1185	polyribonucleotide nucleotidyltransferase activity
ACIPR4_RS09200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACIPR4_RS09220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACIPR4_RS09225	COG1063	alcohol dehydrogenase
ACIPR4_RS09230	COG1562	ergosterol biosynthetic process
ACIPR4_RS09235	COG1562	ergosterol biosynthetic process
ACIPR4_RS09240	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ACIPR4_RS09280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIPR4_RS09285	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACIPR4_RS09295	COG3411	Ferredoxin
ACIPR4_RS09315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACIPR4_RS09325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACIPR4_RS09335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACIPR4_RS09345	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACIPR4_RS09350	COG1956	GAF domain-containing protein
ACIPR4_RS09365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ACIPR4_RS09400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACIPR4_RS09405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACIPR4_RS09410	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACIPR4_RS09425	COG0009	L-threonylcarbamoyladenylate synthase
ACIPR4_RS09455	COG0477	Major facilitator Superfamily
ACIPR4_RS09480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACIPR4_RS09485	COG0436	Aminotransferase
ACIPR4_RS09490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACIPR4_RS09495	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACIPR4_RS09530	COG3620	sequence-specific DNA binding
ACIPR4_RS09555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACIPR4_RS09575	COG1136	(ABC) transporter
ACIPR4_RS09575	COG0577	efflux transmembrane transporter activity
ACIPR4_RS09595	COG2818	Glycosylase
ACIPR4_RS09630	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIPR4_RS09655	COG0825	malonyl-CoA metabolic process
ACIPR4_RS09685	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACIPR4_RS09690	COG0351	phosphomethylpyrimidine kinase
ACIPR4_RS09715	COG0438	transferase activity, transferring glycosyl groups
ACIPR4_RS09725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACIPR4_RS09790	COG0438	transferase activity, transferring glycosyl groups
ACIPR4_RS09800	COG0438	transferase activity, transferring glycosyl groups
ACIPR4_RS09805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACIPR4_RS09805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACIPR4_RS09815	COG2080	2 iron, 2 sulfur cluster binding
ACIPR4_RS09820	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ACIPR4_RS09825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACIPR4_RS09830	COG0514	ATP-dependent DNA helicase (RecQ)
ACIPR4_RS09835	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ACIPR4_RS09840	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ACIPR4_RS09845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACIPR4_RS09850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACIPR4_RS09875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACIPR4_RS09880	COG4191	Histidine kinase
ACIPR4_RS09890	COG1063	alcohol dehydrogenase
ACIPR4_RS09905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACIPR4_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS09930	COG1657	PFAM Prenyltransferase squalene oxidase
ACIPR4_RS09935	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACIPR4_RS09940	COG0497	DNA recombination
ACIPR4_RS09960	COG0823	Involved in the tonB-independent uptake of proteins
ACIPR4_RS09965	COG2885	chlorophyll binding
ACIPR4_RS09970	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACIPR4_RS09980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACIPR4_RS09985	COG0505	Belongs to the CarA family
ACIPR4_RS10000	COG2259	Doxx family
ACIPR4_RS10010	COG0022	dehydrogenase e1 component
ACIPR4_RS10025	COG0668	transmembrane transport
ACIPR4_RS10030	COG1331	Highly conserved protein containing a thioredoxin domain
ACIPR4_RS10040	COG0101	tRNA pseudouridine synthase activity
ACIPR4_RS10055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACIPR4_RS10085	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACIPR4_RS10095	COG0534	Mate efflux family protein
ACIPR4_RS10140	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS10145	COG0531	amino acid
ACIPR4_RS10150	COG0531	amino acid
ACIPR4_RS10155	COG0352	thiamine-phosphate diphosphorylase activity
ACIPR4_RS10160	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS10165	COG2070	2-Nitropropane dioxygenase
ACIPR4_RS10170	COG2311	Membrane
ACIPR4_RS10180	COG0439	Biotin carboxylase
ACIPR4_RS10185	COG0511	ligase activity, forming carbon-carbon bonds
ACIPR4_RS10190	COG0006	proline dipeptidase activity
ACIPR4_RS10195	COG1408	metallophosphoesterase
ACIPR4_RS10210	COG2826	transposase and inactivated derivatives, IS30 family
ACIPR4_RS10215	COG0067	glutamate synthase
ACIPR4_RS10215	COG0069	glutamate synthase activity
ACIPR4_RS10215	COG0070	glutamate synthase
ACIPR4_RS10220	COG1438	arginine binding
ACIPR4_RS10225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACIPR4_RS10230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACIPR4_RS10235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACIPR4_RS10240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACIPR4_RS10245	COG0137	argininosuccinate synthase activity
ACIPR4_RS10250	COG0165	Argininosuccinate lyase
ACIPR4_RS10270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACIPR4_RS10275	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS10295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACIPR4_RS10305	COG0028	Belongs to the TPP enzyme family
ACIPR4_RS10340	COG0586	Pfam SNARE associated Golgi protein
ACIPR4_RS10355	COG2183	response to ionizing radiation
ACIPR4_RS10360	COG1595	DNA-templated transcription, initiation
ACIPR4_RS10380	COG0784	Response regulator, receiver
ACIPR4_RS10395	COG5001	Diguanylate cyclase
ACIPR4_RS10405	COG1620	l-lactate permease
ACIPR4_RS10415	COG1410	methionine synthase
ACIPR4_RS10415	COG0646	methionine synthase
ACIPR4_RS10420	COG2197	response regulator
ACIPR4_RS10445	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACIPR4_RS10450	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
ACIPR4_RS10460	COG0535	radical SAM domain protein
ACIPR4_RS10485	COG2205	protein histidine kinase activity
ACIPR4_RS10490	COG0745	RESPONSE REGULATOR receiver
ACIPR4_RS10505	COG4716	Myosin-crossreactive antigen
ACIPR4_RS10515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACIPR4_RS10520	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS10550	COG1136	(ABC) transporter
ACIPR4_RS10565	COG1522	sequence-specific DNA binding
ACIPR4_RS10570	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACIPR4_RS10575	COG4948	Mandelate Racemase Muconate Lactonizing
ACIPR4_RS10580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACIPR4_RS10595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACIPR4_RS10615	COG4191	Histidine kinase
ACIPR4_RS10620	COG2204	response regulator
ACIPR4_RS10625	COG0406	alpha-ribazole phosphatase activity
ACIPR4_RS10645	COG4106	trans-aconitate 2-methyltransferase activity
ACIPR4_RS10650	COG0326	Molecular chaperone. Has ATPase activity
ACIPR4_RS10655	COG1643	Atp-dependent helicase
ACIPR4_RS10680	COG2819	hydrolase of the alpha beta superfamily
ACIPR4_RS10685	COG0228	four-way junction DNA binding
ACIPR4_RS10690	COG1837	Belongs to the UPF0109 family
ACIPR4_RS10695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACIPR4_RS10705	COG0336	Belongs to the RNA methyltransferase TrmD family
ACIPR4_RS10715	COG0335	large ribosomal subunit rRNA binding
ACIPR4_RS10725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACIPR4_RS10740	COG1414	Transcriptional regulator
ACIPR4_RS10750	COG1696	Membrane protein involved in D-alanine export
ACIPR4_RS10755	COG1482	cell wall glycoprotein biosynthetic process
ACIPR4_RS10765	COG3850	Histidine kinase
ACIPR4_RS10765	COG0642	Histidine kinase
ACIPR4_RS10770	COG0745	RESPONSE REGULATOR receiver
ACIPR4_RS10775	COG0795	lipopolysaccharide-transporting ATPase activity
ACIPR4_RS10780	COG0545	Peptidyl-prolyl cis-trans isomerase
ACIPR4_RS10785	COG1132	(ABC) transporter
ACIPR4_RS10795	COG1566	PFAM secretion protein HlyD family protein
ACIPR4_RS10805	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS10810	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS10815	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACIPR4_RS10835	COG1088	dTDP-glucose 4,6-dehydratase activity
ACIPR4_RS10840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACIPR4_RS10855	COG0745	RESPONSE REGULATOR receiver
ACIPR4_RS10890	COG1136	(ABC) transporter
ACIPR4_RS10890	COG0577	efflux transmembrane transporter activity
ACIPR4_RS10895	COG0577	efflux transmembrane transporter activity
ACIPR4_RS10895	COG1136	(ABC) transporter
ACIPR4_RS10910	COG0047	phosphoribosylformylglycinamidine synthase activity
ACIPR4_RS10915	COG4464	protein tyrosine phosphatase activity
ACIPR4_RS10920	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS10930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACIPR4_RS10935	COG0459	protein refolding
ACIPR4_RS10980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACIPR4_RS10985	COG1132	(ABC) transporter
ACIPR4_RS10990	COG1392	Phosphate transport regulator
ACIPR4_RS10995	COG0306	phosphate transporter
ACIPR4_RS11000	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIPR4_RS11010	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACIPR4_RS11020	COG1640	4-alpha-glucanotransferase
ACIPR4_RS11025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIPR4_RS11065	COG0745	RESPONSE REGULATOR receiver
ACIPR4_RS11070	COG5002	protein histidine kinase activity
ACIPR4_RS11110	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
ACIPR4_RS11130	COG2207	Transcriptional regulator
ACIPR4_RS11140	COG3940	Belongs to the glycosyl hydrolase 43 family
ACIPR4_RS11185	COG3220	belongs to the UPF0276 family
ACIPR4_RS11220	COG0823	Involved in the tonB-independent uptake of proteins
ACIPR4_RS11220	COG1506	peptidase
ACIPR4_RS11235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACIPR4_RS11250	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACIPR4_RS11265	COG1136	(ABC) transporter
ACIPR4_RS11265	COG0577	efflux transmembrane transporter activity
ACIPR4_RS11280	COG2205	protein histidine kinase activity
ACIPR4_RS11300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACIPR4_RS11330	COG2267	carboxylic ester hydrolase activity
ACIPR4_RS11355	COG3604	Transcriptional regulator
ACIPR4_RS11385	COG1309	transcriptional regulator
ACIPR4_RS11400	COG1538	Outer membrane efflux protein
ACIPR4_RS11405	COG1309	transcriptional regulator
ACIPR4_RS11410	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS11435	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS11475	COG1082	Xylose isomerase domain protein TIM barrel
ACIPR4_RS11490	COG1609	Transcriptional regulator
ACIPR4_RS11530	COG2132	Multicopper oxidase
ACIPR4_RS11530	COG2132	Multicopper oxidase
ACIPR4_RS11540	COG0528	UMP kinase activity
ACIPR4_RS11545	COG0528	UMP kinase activity
ACIPR4_RS11590	COG5492	domain, Protein
ACIPR4_RS11590	COG4932	domain protein
ACIPR4_RS11630	COG2311	Membrane
ACIPR4_RS11640	COG3620	sequence-specific DNA binding
ACIPR4_RS11645	COG3550	peptidyl-serine autophosphorylation
ACIPR4_RS11685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACIPR4_RS11700	COG0583	DNA-binding transcription factor activity
ACIPR4_RS11705	COG0582	viral genome integration into host DNA
ACIPR4_RS11730	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS11740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIPR4_RS11740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIPR4_RS11745	COG2207	Transcriptional regulator
ACIPR4_RS11765	COG0667	Aldo Keto reductase
ACIPR4_RS11775	COG1064	alcohol dehydrogenase
ACIPR4_RS11785	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS11790	COG2207	Transcriptional regulator
ACIPR4_RS11795	COG1475	DNA binding
ACIPR4_RS11815	COG1196	nuclear chromosome segregation
ACIPR4_RS11875	COG0629	single-stranded DNA binding
ACIPR4_RS11880	COG4962	Type ii secretion system protein e
ACIPR4_RS11890	COG1396	sequence-specific DNA binding
ACIPR4_RS11975	COG2205	protein histidine kinase activity
ACIPR4_RS11980	COG0745	RESPONSE REGULATOR receiver
ACIPR4_RS12000	COG1953	Uracil, thiamine, allantoin
ACIPR4_RS12010	COG2203	Gaf domain
ACIPR4_RS12010	COG5001	Diguanylate cyclase
ACIPR4_RS12010	COG4251	negative regulation of phosphorylation
ACIPR4_RS12010	COG3706	GGDEF domain
ACIPR4_RS12020	COG0657	acetylesterase activity
ACIPR4_RS12035	COG1501	Belongs to the glycosyl hydrolase 31 family
ACIPR4_RS12065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACIPR4_RS12095	COG0438	transferase activity, transferring glycosyl groups
ACIPR4_RS12135	COG0438	transferase activity, transferring glycosyl groups
ACIPR4_RS12155	COG0626	cystathionine gamma-synthase activity
ACIPR4_RS12165	COG3394	polysaccharide catabolic process
ACIPR4_RS12170	COG3275	phosphorelay sensor kinase activity
ACIPR4_RS12175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACIPR4_RS12190	COG0322	excinuclease ABC activity
ACIPR4_RS12215	COG2321	neutral zinc metallopeptidase
ACIPR4_RS12220	COG3537	Alpha-1,2-mannosidase
ACIPR4_RS12255	COG0531	amino acid
ACIPR4_RS12260	COG0297	glycogen (starch) synthase activity
ACIPR4_RS12265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACIPR4_RS12280	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACIPR4_RS12285	COG2022	thiamine diphosphate biosynthetic process
ACIPR4_RS12305	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ACIPR4_RS12315	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIPR4_RS12320	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIPR4_RS12325	COG0649	NAD binding
ACIPR4_RS12350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACIPR4_RS12360	COG0713	ATP synthesis coupled electron transport
ACIPR4_RS12375	COG1007	ATP synthesis coupled electron transport
ACIPR4_RS12380	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACIPR4_RS12385	COG0356	it plays a direct role in the translocation of protons across the membrane
ACIPR4_RS12405	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACIPR4_RS12410	COG1692	metallophosphoesterase
ACIPR4_RS12420	COG1196	nuclear chromosome segregation
ACIPR4_RS12465	COG2222	sugar isomerase
ACIPR4_RS12470	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS12480	COG1349	DNA-binding transcription factor activity
ACIPR4_RS12540	COG1392	Phosphate transport regulator
ACIPR4_RS12545	COG0306	phosphate transporter
ACIPR4_RS12560	COG0539	negative regulation of cytoplasmic translation
ACIPR4_RS12565	COG1064	alcohol dehydrogenase
ACIPR4_RS12580	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ACIPR4_RS12610	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACIPR4_RS12610	COG2755	lipolytic protein G-D-S-L family
ACIPR4_RS12620	COG1268	BioY protein
ACIPR4_RS12640	COG1136	(ABC) transporter
ACIPR4_RS12640	COG0577	efflux transmembrane transporter activity
ACIPR4_RS12650	COG2204	response regulator
ACIPR4_RS12660	COG1136	(ABC) transporter
ACIPR4_RS12660	COG0577	efflux transmembrane transporter activity
ACIPR4_RS12665	COG0577	efflux transmembrane transporter activity
ACIPR4_RS12665	COG1136	(ABC) transporter
ACIPR4_RS12680	COG0577	efflux transmembrane transporter activity
ACIPR4_RS12680	COG1136	(ABC) transporter
ACIPR4_RS12695	COG2252	PERMEase
ACIPR4_RS12705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACIPR4_RS12705	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACIPR4_RS12715	COG1127	ABC transporter
ACIPR4_RS12730	COG2226	methyltransferase
ACIPR4_RS12740	COG2204	response regulator
ACIPR4_RS12745	COG3852	Histidine kinase
ACIPR4_RS12755	COG0653	protein targeting
ACIPR4_RS12770	COG4974	Belongs to the 'phage' integrase family
ACIPR4_RS12795	COG1253	flavin adenine dinucleotide binding
ACIPR4_RS12810	COG0494	nUDIX hydrolase
ACIPR4_RS12835	COG1704	LemA family
ACIPR4_RS12855	COG1132	(ABC) transporter
ACIPR4_RS12895	COG0463	Glycosyl transferase, family 2
ACIPR4_RS12910	COG1668	transmembrane transport
ACIPR4_RS12915	COG4152	abc transporter atp-binding protein
ACIPR4_RS12925	COG1363	Peptidase, m42
ACIPR4_RS12975	COG0438	transferase activity, transferring glycosyl groups
ACIPR4_RS13005	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACIPR4_RS13005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACIPR4_RS13025	COG1819	glycosyl
ACIPR4_RS13040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACIPR4_RS13045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACIPR4_RS13050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACIPR4_RS13060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACIPR4_RS13075	COG0450	alkyl hydroperoxide reductase
ACIPR4_RS13085	COG1136	(ABC) transporter
ACIPR4_RS13085	COG0577	efflux transmembrane transporter activity
ACIPR4_RS13105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIPR4_RS13110	COG1309	transcriptional regulator
ACIPR4_RS13125	COG4948	Mandelate Racemase Muconate Lactonizing
ACIPR4_RS13130	COG1940	carbohydrate kinase activity
ACIPR4_RS13135	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS13145	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS13150	COG3940	Belongs to the glycosyl hydrolase 43 family
ACIPR4_RS13185	COG2382	esterase
ACIPR4_RS13190	COG0531	amino acid
ACIPR4_RS13200	COG1063	alcohol dehydrogenase
ACIPR4_RS13210	COG3254	rhamnose metabolic process
ACIPR4_RS13230	COG3250	beta-galactosidase activity
ACIPR4_RS13275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIPR4_RS13280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIPR4_RS13320	COG0745	RESPONSE REGULATOR receiver
ACIPR4_RS13340	COG1450	Type ii and iii secretion system protein
ACIPR4_RS13350	COG1837	Belongs to the UPF0109 family
ACIPR4_RS13370	COG3344	reverse transcriptase
ACIPR4_RS13375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACIPR4_RS13380	COG0640	Transcriptional regulator
ACIPR4_RS13385	COG0798	PFAM Bile acid sodium symporter
ACIPR4_RS13390	COG1695	Transcriptional regulator
ACIPR4_RS13410	COG0823	Involved in the tonB-independent uptake of proteins
ACIPR4_RS13470	COG1091	dTDP-4-dehydrorhamnose reductase activity
ACIPR4_RS13475	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ACIPR4_RS13475	COG0662	Cupin 2, conserved barrel domain protein
ACIPR4_RS13485	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ACIPR4_RS13490	COG1609	Transcriptional regulator
ACIPR4_RS13520	COG3250	beta-galactosidase activity
ACIPR4_RS13545	COG1136	(ABC) transporter
ACIPR4_RS13545	COG0577	efflux transmembrane transporter activity
ACIPR4_RS13550	COG0577	efflux transmembrane transporter activity
ACIPR4_RS13570	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS13580	COG2271	Major facilitator Superfamily
ACIPR4_RS13585	COG0363	glucosamine-6-phosphate deaminase activity
ACIPR4_RS13610	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS13625	COG1414	Transcriptional regulator
ACIPR4_RS13645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACIPR4_RS13650	COG0363	glucosamine-6-phosphate deaminase activity
ACIPR4_RS13665	COG1609	Transcriptional regulator
ACIPR4_RS13675	COG1902	pentaerythritol trinitrate reductase activity
ACIPR4_RS13680	COG3118	belongs to the thioredoxin family
ACIPR4_RS13700	COG0366	Alpha amylase catalytic
ACIPR4_RS13770	COG3119	arylsulfatase activity
ACIPR4_RS13780	COG3275	phosphorelay sensor kinase activity
ACIPR4_RS13785	COG3279	Response regulator of the LytR AlgR family
ACIPR4_RS13790	COG2133	pyrroloquinoline quinone binding
ACIPR4_RS13805	COG0745	RESPONSE REGULATOR receiver
ACIPR4_RS13835	COG2115	Belongs to the xylose isomerase family
ACIPR4_RS13860	COG1595	DNA-templated transcription, initiation
ACIPR4_RS13875	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS13890	COG1446	asparaginase
ACIPR4_RS13900	COG2423	ornithine cyclodeaminase activity
ACIPR4_RS13905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACIPR4_RS13910	COG0601	transmembrane transport
ACIPR4_RS13915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACIPR4_RS13920	COG4172	Belongs to the ABC transporter superfamily
ACIPR4_RS13930	COG2828	Protein conserved in bacteria
ACIPR4_RS13935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACIPR4_RS13940	COG4166	transmembrane transport
ACIPR4_RS13955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACIPR4_RS13970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACIPR4_RS14015	COG1454	alcohol dehydrogenase
ACIPR4_RS14025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACIPR4_RS14030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ACIPR4_RS14035	COG3395	kinase activity
ACIPR4_RS14085	COG0300	oxidoreductase activity
ACIPR4_RS14095	COG3710	Transcriptional regulator
ACIPR4_RS14125	COG0492	ferredoxin-NADP+ reductase activity
ACIPR4_RS14130	COG0463	Glycosyl transferase, family 2
ACIPR4_RS14175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACIPR4_RS14195	COG2205	protein histidine kinase activity
ACIPR4_RS14200	COG0745	RESPONSE REGULATOR receiver
ACIPR4_RS14210	COG5002	protein histidine kinase activity
ACIPR4_RS14250	COG3852	Histidine kinase
ACIPR4_RS14350	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ACIPR4_RS14355	COG2169	Transcriptional regulator
ACIPR4_RS14355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACIPR4_RS14365	COG3145	DNA-N1-methyladenine dioxygenase activity
ACIPR4_RS14375	COG3548	integral membrane protein
ACIPR4_RS14380	COG2207	Transcriptional regulator
ACIPR4_RS14390	COG3547	Transposase (IS116 IS110 IS902 family)
ACIPR4_RS14395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACIPR4_RS14395	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ACIPR4_RS14410	COG2442	InterPro IPR007367
ACIPR4_RS14415	COG4634	DNA integration
ACIPR4_RS14420	COG1733	regulation of RNA biosynthetic process
ACIPR4_RS14440	COG2814	Major facilitator Superfamily
ACIPR4_RS14445	COG1566	PFAM secretion protein HlyD family protein
ACIPR4_RS14465	COG2207	Transcriptional regulator
ACIPR4_RS14475	COG1629	transport
ACIPR4_RS14480	COG3128	pkhd-type hydroxylase
ACIPR4_RS14520	COG1475	DNA binding
ACIPR4_RS14585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACIPR4_RS14645	COG4962	Type ii secretion system protein e
ACIPR4_RS14725	COG1595	DNA-templated transcription, initiation
ACIPR4_RS14740	COG0463	Glycosyl transferase, family 2
ACIPR4_RS14750	COG3547	Transposase (IS116 IS110 IS902 family)
ACIPR4_RS14765	COG0824	Thioesterase
ACIPR4_RS14770	COG1335	isochorismatase
ACIPR4_RS14780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACIPR4_RS14795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACIPR4_RS14800	COG0750	zinc metalloprotease
ACIPR4_RS14850	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ACIPR4_RS14855	COG0494	nUDIX hydrolase
ACIPR4_RS14860	COG1278	Cold shock
ACIPR4_RS14865	COG1796	DNA polymerase
ACIPR4_RS14865	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ACIPR4_RS14880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACIPR4_RS14880	COG2022	thiamine diphosphate biosynthetic process
ACIPR4_RS14885	COG0372	Belongs to the citrate synthase family
ACIPR4_RS14890	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS14895	COG1418	mRNA catabolic process
ACIPR4_RS14900	COG4774	siderophore transport
ACIPR4_RS14940	COG0583	DNA-binding transcription factor activity
ACIPR4_RS14945	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS14955	COG0482	sulfurtransferase activity
ACIPR4_RS14995	COG1543	Belongs to the glycosyl hydrolase 57 family
ACIPR4_RS15010	COG2062	phosphohistidine phosphatase, SixA
ACIPR4_RS15015	COG0248	Ppx GppA phosphatase
ACIPR4_RS15020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACIPR4_RS15035	COG0789	Transcriptional regulator
ACIPR4_RS15040	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS15045	COG0484	heat shock protein binding
ACIPR4_RS15065	COG3549	Plasmid maintenance system killer
ACIPR4_RS15070	COG0443	Heat shock 70 kDa protein
ACIPR4_RS15105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACIPR4_RS15115	COG0316	Belongs to the HesB IscA family
ACIPR4_RS15135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACIPR4_RS15135	COG2755	lipolytic protein G-D-S-L family
ACIPR4_RS15140	COG0528	UMP kinase activity
ACIPR4_RS15145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACIPR4_RS15150	COG0052	Belongs to the universal ribosomal protein uS2 family
ACIPR4_RS15155	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACIPR4_RS15160	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACIPR4_RS15175	COG0577	efflux transmembrane transporter activity
ACIPR4_RS15185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACIPR4_RS15205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACIPR4_RS15205	COG2169	Transcriptional regulator
ACIPR4_RS15210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACIPR4_RS15225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACIPR4_RS15230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACIPR4_RS15235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACIPR4_RS15240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACIPR4_RS15245	COG0131	Imidazoleglycerol-phosphate dehydratase
ACIPR4_RS15250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACIPR4_RS15255	COG0107	imidazoleglycerol-phosphate synthase activity
ACIPR4_RS15260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACIPR4_RS15290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACIPR4_RS15300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACIPR4_RS15315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACIPR4_RS15320	COG0509	glycine decarboxylation via glycine cleavage system
ACIPR4_RS15330	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACIPR4_RS15340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACIPR4_RS15380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACIPR4_RS15455	COG0488	(ABC) transporter
ACIPR4_RS15465	COG0330	HflC and HflK could
ACIPR4_RS15470	COG1725	Transcriptional regulator
ACIPR4_RS15480	COG0519	Catalyzes the synthesis of GMP from XMP
ACIPR4_RS15480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACIPR4_RS15490	COG0495	leucyl-tRNA aminoacylation
ACIPR4_RS15500	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACIPR4_RS15515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACIPR4_RS15520	COG0758	DNA mediated transformation
ACIPR4_RS15530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACIPR4_RS15540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACIPR4_RS15555	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACIPR4_RS15575	COG1058	Belongs to the CinA family
ACIPR4_RS15575	COG1546	Belongs to the CinA family
ACIPR4_RS15580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACIPR4_RS15585	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACIPR4_RS15590	COG0552	protein localization to endoplasmic reticulum
ACIPR4_RS15605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIPR4_RS15605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIPR4_RS15610	COG0307	riboflavin synthase, alpha
ACIPR4_RS15615	COG1435	thymidine kinase activity
ACIPR4_RS15625	COG0393	Putative heavy-metal-binding
ACIPR4_RS15630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACIPR4_RS15635	COG0045	succinate-CoA ligase (ADP-forming) activity
ACIPR4_RS15640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ACIPR4_RS15645	COG0105	UTP biosynthetic process
ACIPR4_RS15665	COG1595	DNA-templated transcription, initiation
ACIPR4_RS15670	COG2032	superoxide dismutase activity
ACIPR4_RS15745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACIPR4_RS15755	COG1252	NADH dehydrogenase
ACIPR4_RS15760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACIPR4_RS15765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACIPR4_RS15770	COG1295	ribonuclease BN
ACIPR4_RS15775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACIPR4_RS15795	COG1872	DUF167
ACIPR4_RS15800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACIPR4_RS15835	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACIPR4_RS15840	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACIPR4_RS15870	COG0516	GMP reductase activity
ACIPR4_RS15870	COG0517	IMP dehydrogenase activity
ACIPR4_RS15875	COG2199	diguanylate cyclase activity
ACIPR4_RS15875	COG2200	EAL domain
ACIPR4_RS15875	COG3287	FIST C domain
ACIPR4_RS15885	COG0779	Required for maturation of 30S ribosomal subunits
ACIPR4_RS15890	COG0195	Participates in both transcription termination and antitermination
ACIPR4_RS15895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACIPR4_RS15955	COG0203	ribosomal protein L17
ACIPR4_RS15960	COG0202	RNA polymerase activity
ACIPR4_RS15965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACIPR4_RS15970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACIPR4_RS15975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACIPR4_RS15980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACIPR4_RS15985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACIPR4_RS15995	COG0563	adenylate kinase activity
ACIPR4_RS16005	COG0200	Binds to the 23S rRNA
ACIPR4_RS16010	COG1841	ribosomal large subunit assembly
ACIPR4_RS16015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACIPR4_RS16020	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACIPR4_RS16025	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACIPR4_RS16030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACIPR4_RS16040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACIPR4_RS16045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACIPR4_RS16050	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACIPR4_RS16055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACIPR4_RS16060	COG0255	Belongs to the universal ribosomal protein uL29 family
ACIPR4_RS16065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACIPR4_RS16070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACIPR4_RS16075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACIPR4_RS16080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACIPR4_RS16085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACIPR4_RS16090	COG0089	rRNA binding
ACIPR4_RS16095	COG0088	Forms part of the polypeptide exit tunnel
ACIPR4_RS16100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACIPR4_RS16105	COG0051	transcription antitermination factor activity, RNA binding
ACIPR4_RS16110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACIPR4_RS16115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACIPR4_RS16120	COG0049	tRNA binding
ACIPR4_RS16125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACIPR4_RS16140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACIPR4_RS16150	COG0823	Involved in the tonB-independent uptake of proteins
ACIPR4_RS16150	COG1506	peptidase
ACIPR4_RS16150	COG4946	Tricorn protease homolog
ACIPR4_RS16175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACIPR4_RS16185	COG0631	protein serine/threonine phosphatase activity
ACIPR4_RS16205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACIPR4_RS16210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACIPR4_RS16215	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACIPR4_RS16225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACIPR4_RS16230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACIPR4_RS16245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACIPR4_RS16250	COG1923	regulation of RNA biosynthetic process
ACIPR4_RS16265	COG2814	Major facilitator Superfamily
ACIPR4_RS16270	COG1309	transcriptional regulator
ACIPR4_RS16310	COG0180	Tryptophanyl-tRNA synthetase
ACIPR4_RS16315	COG1994	Peptidase M50
ACIPR4_RS16360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACIPR4_RS16380	COG0706	membrane insertase activity
ACIPR4_RS16390	COG0667	Aldo Keto reductase
ACIPR4_RS16400	COG0504	CTP synthase activity
ACIPR4_RS16430	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACIPR4_RS16450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACIPR4_RS16470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACIPR4_RS16475	COG2308	Evidence 4 Homologs of previously reported genes of
ACIPR4_RS16485	COG1305	Transglutaminase-like
ACIPR4_RS16510	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACIPR4_RS16515	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACIPR4_RS16525	COG0187	DNA topoisomerase II activity
ACIPR4_RS16540	COG0154	amidase activity
ACIPR4_RS16545	COG4221	oxidoreductase activity
ACIPR4_RS16555	COG4095	Psort location CytoplasmicMembrane, score
ACIPR4_RS16600	COG0535	radical SAM domain protein
ACIPR4_RS16610	COG1217	gtp-binding protein TYPA
ACIPR4_RS16620	COG1611	Belongs to the LOG family
ACIPR4_RS16625	COG0366	Alpha amylase catalytic
ACIPR4_RS16635	COG0488	(ABC) transporter
ACIPR4_RS16645	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACIPR4_RS16660	COG0738	Major facilitator superfamily
ACIPR4_RS16665	COG3300	MHYT domain
ACIPR4_RS16665	COG5001	Diguanylate cyclase
ACIPR4_RS16670	COG5001	Diguanylate cyclase
ACIPR4_RS16670	COG3300	MHYT domain
ACIPR4_RS16715	COG1802	Transcriptional regulator
ACIPR4_RS16720	COG1012	belongs to the aldehyde dehydrogenase family
ACIPR4_RS16755	COG3179	chitinase
ACIPR4_RS16770	COG0531	amino acid
ACIPR4_RS16775	COG2814	Major facilitator Superfamily
ACIPR4_RS16780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACIPR4_RS16795	COG0438	transferase activity, transferring glycosyl groups
ACIPR4_RS16810	COG1136	(ABC) transporter
ACIPR4_RS16810	COG0577	efflux transmembrane transporter activity
ACIPR4_RS16840	COG3706	GGDEF domain
ACIPR4_RS16840	COG4251	negative regulation of phosphorylation
ACIPR4_RS16840	COG5001	Diguanylate cyclase
ACIPR4_RS16840	COG2203	Gaf domain
ACIPR4_RS16850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACIPR4_RS16875	COG0242	peptide deformylase activity
ACIPR4_RS16900	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ACIPR4_RS16905	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ACIPR4_RS16910	COG0515	serine threonine protein kinase
ACIPR4_RS16910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACIPR4_RS16915	COG0577	efflux transmembrane transporter activity
ACIPR4_RS16920	COG1136	(ABC) transporter
ACIPR4_RS16925	COG1231	oxidoreductase activity
ACIPR4_RS16930	COG1309	transcriptional regulator
ACIPR4_RS16935	COG0300	oxidoreductase activity
ACIPR4_RS16940	COG1040	competence protein
ACIPR4_RS16955	COG0539	negative regulation of cytoplasmic translation
ACIPR4_RS16960	COG0697	spore germination
ACIPR4_RS16970	COG2255	four-way junction helicase activity
ACIPR4_RS16985	COG2826	transposase and inactivated derivatives, IS30 family
ACIPR4_RS17015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACIPR4_RS17025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACIPR4_RS17050	COG0215	cysteine-tRNA ligase activity
ACIPR4_RS17055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACIPR4_RS17060	COG0617	tRNA 3'-terminal CCA addition
ACIPR4_RS17105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACIPR4_RS17125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACIPR4_RS17130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACIPR4_RS17165	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS17175	COG0277	FAD linked oxidase domain protein
ACIPR4_RS17195	COG2723	6-phospho-beta-galactosidase activity
ACIPR4_RS17205	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACIPR4_RS17215	COG0742	ribosomal rna small subunit methyltransferase
ACIPR4_RS17225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACIPR4_RS17265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACIPR4_RS17280	COG0640	Transcriptional regulator
ACIPR4_RS17285	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS17300	COG0590	tRNA wobble adenosine to inosine editing
ACIPR4_RS17305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACIPR4_RS17365	COG0366	Alpha amylase catalytic
ACIPR4_RS17370	COG0366	Alpha amylase catalytic
ACIPR4_RS17385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACIPR4_RS17400	COG0210	DNA helicase
ACIPR4_RS17405	COG0531	amino acid
ACIPR4_RS17435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACIPR4_RS17440	COG0444	Belongs to the ABC transporter superfamily
ACIPR4_RS17450	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACIPR4_RS17455	COG0792	nuclease activity
ACIPR4_RS17485	COG3250	beta-galactosidase activity
ACIPR4_RS17525	COG0859	PFAM glycosyl transferase family 9
ACIPR4_RS17540	COG0438	transferase activity, transferring glycosyl groups
ACIPR4_RS17550	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACIPR4_RS17555	COG0154	amidase activity
ACIPR4_RS17575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACIPR4_RS17585	COG1199	ATP-dependent helicase activity
ACIPR4_RS17605	COG1297	OPT oligopeptide transporter protein
ACIPR4_RS17620	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACIPR4_RS17625	COG0571	ribonuclease III activity
ACIPR4_RS17630	COG0681	Belongs to the peptidase S26 family
ACIPR4_RS17635	COG0681	Belongs to the peptidase S26 family
ACIPR4_RS17640	COG0681	Belongs to the peptidase S26 family
ACIPR4_RS17655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACIPR4_RS17675	COG3279	Response regulator of the LytR AlgR family
ACIPR4_RS17695	COG3961	Belongs to the TPP enzyme family
ACIPR4_RS17710	COG2897	thiosulfate sulfurtransferase activity
ACIPR4_RS17715	COG0450	alkyl hydroperoxide reductase
ACIPR4_RS17740	COG0315	cyclic pyranopterin monophosphate synthase activity
ACIPR4_RS17745	COG0303	'Molybdopterin
ACIPR4_RS17755	COG1136	(ABC) transporter
ACIPR4_RS17755	COG0577	efflux transmembrane transporter activity
ACIPR4_RS17765	COG2318	DinB family
ACIPR4_RS17775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACIPR4_RS17795	COG0788	formyltetrahydrofolate deformylase activity
ACIPR4_RS17800	COG0602	queuosine metabolic process
ACIPR4_RS17805	COG0720	synthase
ACIPR4_RS17825	COG1201	RNA secondary structure unwinding
ACIPR4_RS17855	COG0583	DNA-binding transcription factor activity
ACIPR4_RS17880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIPR4_RS17925	COG3459	Glycosyltransferase 36 associated
ACIPR4_RS17950	COG3403	YqcI/YcgG family
ACIPR4_RS17955	COG4206	TonB-dependent receptor
ACIPR4_RS17960	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACIPR4_RS17990	COG2207	Transcriptional regulator
ACIPR4_RS17990	COG0662	Cupin 2, conserved barrel domain protein
ACIPR4_RS17995	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ACIPR4_RS18000	COG1309	transcriptional regulator
ACIPR4_RS18025	COG1819	glycosyl
ACIPR4_RS18045	COG1595	DNA-templated transcription, initiation
ACIPR4_RS18085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACIPR4_RS18100	COG0584	glycerophosphoryl diester phosphodiesterase
ACIPR4_RS18115	COG0475	glutathione-regulated potassium exporter activity
ACIPR4_RS18120	COG0175	sulfate reduction
ACIPR4_RS18125	COG2895	sulfate adenylyltransferase (ATP) activity
ACIPR4_RS18130	COG0175	sulfate reduction
ACIPR4_RS18140	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACIPR4_RS18145	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACIPR4_RS18150	COG0477	Major facilitator Superfamily
ACIPR4_RS18170	COG1595	DNA-templated transcription, initiation
ACIPR4_RS18205	COG0577	efflux transmembrane transporter activity
ACIPR4_RS18220	COG0577	efflux transmembrane transporter activity
ACIPR4_RS18220	COG1136	(ABC) transporter
ACIPR4_RS18235	COG1215	transferase activity, transferring glycosyl groups
ACIPR4_RS18245	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ACIPR4_RS18270	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS18305	COG0481	GTPase activity
ACIPR4_RS18310	COG3942	CHAP domain
ACIPR4_RS18310	COG1388	LysM domain
ACIPR4_RS18320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACIPR4_RS18345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACIPR4_RS18380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACIPR4_RS18400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACIPR4_RS18410	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACIPR4_RS18440	COG0110	maltose O-acetyltransferase activity
ACIPR4_RS18465	COG2207	Transcriptional regulator
ACIPR4_RS18475	COG2267	carboxylic ester hydrolase activity
ACIPR4_RS18480	COG4804	nuclease activity
ACIPR4_RS18490	COG1902	pentaerythritol trinitrate reductase activity
ACIPR4_RS18530	COG0583	DNA-binding transcription factor activity
ACIPR4_RS18535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACIPR4_RS18540	COG0251	oxidation-reduction process
ACIPR4_RS18545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACIPR4_RS18550	COG0583	DNA-binding transcription factor activity
ACIPR4_RS18570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACIPR4_RS18575	COG2226	methyltransferase
ACIPR4_RS18600	COG0596	Alpha beta hydrolase
ACIPR4_RS18615	COG2094	Belongs to the DNA glycosylase MPG family
ACIPR4_RS18640	COG1475	DNA binding
ACIPR4_RS18700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACIPR4_RS18710	COG0420	3'-5' exonuclease activity
ACIPR4_RS18750	COG4962	Type ii secretion system protein e
ACIPR4_RS18850	COG2826	transposase and inactivated derivatives, IS30 family
ACIPR4_RS18860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACIPR4_RS18865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACIPR4_RS18870	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ACIPR4_RS18875	COG0557	exoribonuclease II activity
ACIPR4_RS18880	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS18890	COG1215	transferase activity, transferring glycosyl groups
ACIPR4_RS18895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACIPR4_RS18900	COG3594	Acyltransferase
ACIPR4_RS18915	COG1506	peptidase
ACIPR4_RS18915	COG0823	Involved in the tonB-independent uptake of proteins
ACIPR4_RS18930	COG0358	DNA primase activity
ACIPR4_RS18945	COG0859	PFAM glycosyl transferase family 9
ACIPR4_RS18955	COG1519	Transferase
ACIPR4_RS18975	COG0756	dUTP diphosphatase activity
ACIPR4_RS18980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACIPR4_RS18985	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
ACIPR4_RS18990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACIPR4_RS19010	COG0151	Belongs to the GarS family
ACIPR4_RS19015	COG1914	H( )-stimulated, divalent metal cation uptake system
ACIPR4_RS19030	COG0251	oxidation-reduction process
ACIPR4_RS19040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACIPR4_RS19060	COG0644	oxidoreductase
ACIPR4_RS19065	COG1309	transcriptional regulator
ACIPR4_RS19075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACIPR4_RS19080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACIPR4_RS19095	COG1501	Belongs to the glycosyl hydrolase 31 family
ACIPR4_RS19120	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS19170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACIPR4_RS19190	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACIPR4_RS19195	COG2197	response regulator
ACIPR4_RS19210	COG1131	(ABC) transporter
ACIPR4_RS19230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACIPR4_RS19240	COG2814	Major facilitator Superfamily
ACIPR4_RS19250	COG0412	Dienelactone hydrolase
ACIPR4_RS19255	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ACIPR4_RS19265	COG0159	tryptophan synthase activity
ACIPR4_RS19270	COG0133	tryptophan synthase activity
ACIPR4_RS19290	COG3474	cytochrome
ACIPR4_RS19315	COG0135	phosphoribosylanthranilate isomerase activity
ACIPR4_RS19320	COG0134	indole-3-glycerol-phosphate synthase activity
ACIPR4_RS19335	COG0745	RESPONSE REGULATOR receiver
ACIPR4_RS19360	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACIPR4_RS19365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACIPR4_RS19370	COG3706	GGDEF domain
ACIPR4_RS19420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACIPR4_RS19430	COG2226	methyltransferase
ACIPR4_RS19445	COG0577	efflux transmembrane transporter activity
ACIPR4_RS19445	COG1136	(ABC) transporter
ACIPR4_RS19480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACIPR4_RS19485	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ACIPR4_RS19490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACIPR4_RS19495	COG0386	Belongs to the glutathione peroxidase family
ACIPR4_RS19505	COG1278	Cold shock
ACIPR4_RS19510	COG3132	Protein of unknown function, DUF480
ACIPR4_RS19540	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS19565	COG0577	efflux transmembrane transporter activity
ACIPR4_RS19565	COG1136	(ABC) transporter
ACIPR4_RS19580	COG3108	Peptidase M15
ACIPR4_RS19645	COG0753	catalase activity
ACIPR4_RS19650	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS19655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACIPR4_RS19655	COG4221	oxidoreductase activity
ACIPR4_RS19655	COG3321	synthase
ACIPR4_RS19655	COG0604	alcohol dehydrogenase
ACIPR4_RS19665	COG0359	binds to the 23S rRNA
ACIPR4_RS19675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACIPR4_RS19680	COG0360	Binds together with S18 to 16S ribosomal RNA
ACIPR4_RS19685	COG0193	aminoacyl-tRNA hydrolase activity
ACIPR4_RS19690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACIPR4_RS19695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACIPR4_RS19705	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACIPR4_RS19720	COG0542	response to heat
ACIPR4_RS19750	COG2890	protein-(glutamine-N5) methyltransferase activity
ACIPR4_RS19755	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACIPR4_RS19770	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS19780	COG1793	dna ligase
ACIPR4_RS19785	COG0531	amino acid
ACIPR4_RS19790	COG4206	TonB-dependent receptor
ACIPR4_RS19795	COG0667	Aldo Keto reductase
ACIPR4_RS19810	COG0633	Ferredoxin
ACIPR4_RS19830	COG2826	transposase and inactivated derivatives, IS30 family
ACIPR4_RS19855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACIPR4_RS19880	COG0233	cytoplasmic translational termination
ACIPR4_RS19900	COG0243	molybdopterin cofactor binding
ACIPR4_RS19905	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACIPR4_RS19915	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACIPR4_RS20000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACIPR4_RS20005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACIPR4_RS20010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACIPR4_RS20025	COG0676	glucose-6-phosphate 1-epimerase activity
ACIPR4_RS20030	COG0424	maF-like protein
ACIPR4_RS20065	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACIPR4_RS20085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACIPR4_RS20100	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACIPR4_RS20110	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACIPR4_RS20125	COG0343	queuine tRNA-ribosyltransferase activity
ACIPR4_RS20140	COG1862	Preprotein translocase
ACIPR4_RS20145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACIPR4_RS20150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACIPR4_RS20160	COG1845	cytochrome c oxidase, subunit III
ACIPR4_RS20165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACIPR4_RS20170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACIPR4_RS20205	COG0437	4 iron, 4 sulfur cluster binding
ACIPR4_RS20215	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACIPR4_RS20235	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ACIPR4_RS20245	COG1136	(ABC) transporter
ACIPR4_RS20245	COG0577	efflux transmembrane transporter activity
ACIPR4_RS20250	COG1136	(ABC) transporter
ACIPR4_RS20250	COG0577	efflux transmembrane transporter activity
ACIPR4_RS20310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIPR4_RS20315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACIPR4_RS20325	COG2070	2-Nitropropane dioxygenase
ACIPR4_RS20340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACIPR4_RS20345	COG2378	regulation of single-species biofilm formation
ACIPR4_RS20360	COG0305	Participates in initiation and elongation during chromosome replication
ACIPR4_RS20370	COG0445	tRNA wobble uridine modification
ACIPR4_RS20385	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS20415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACIPR4_RS20420	COG1733	regulation of RNA biosynthetic process
ACIPR4_RS20440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACIPR4_RS20445	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACIPR4_RS20480	COG0583	DNA-binding transcription factor activity
ACIPR4_RS20490	COG0799	negative regulation of ribosome biogenesis
ACIPR4_RS20505	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ACIPR4_RS20515	COG2124	cytochrome p450
ACIPR4_RS20520	COG2124	cytochrome p450
ACIPR4_RS20530	COG2814	Major facilitator Superfamily
ACIPR4_RS20580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACIPR4_RS20600	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACIPR4_RS20615	COG4221	oxidoreductase activity
ACIPR4_RS20630	COG0564	pseudouridine synthase activity
ACIPR4_RS20645	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS20655	COG0583	DNA-binding transcription factor activity
ACIPR4_RS20690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACIPR4_RS20695	COG0357	Ribosomal RNA small subunit methyltransferase G
ACIPR4_RS20700	COG1192	Involved in chromosome partitioning
ACIPR4_RS20705	COG1475	DNA binding
ACIPR4_RS20735	COG1136	(ABC) transporter
ACIPR4_RS20735	COG0577	efflux transmembrane transporter activity
ACIPR4_RS20745	COG0776	regulation of translation
ACIPR4_RS20755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACIPR4_RS20755	COG2755	lipolytic protein G-D-S-L family
ACIPR4_RS20760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACIPR4_RS20765	COG0583	DNA-binding transcription factor activity
ACIPR4_RS20770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIPR4_RS20775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIPR4_RS20795	COG3240	lipase activity
ACIPR4_RS20805	COG0432	Pfam Uncharacterised protein family UPF0047
ACIPR4_RS20815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACIPR4_RS20850	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ACIPR4_RS20855	COG4191	Histidine kinase
ACIPR4_RS20900	COG3706	GGDEF domain
ACIPR4_RS20910	COG4191	Histidine kinase
ACIPR4_RS20915	COG1063	alcohol dehydrogenase
ACIPR4_RS20925	COG0673	inositol 2-dehydrogenase activity
ACIPR4_RS20950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACIPR4_RS20970	COG0546	phosphoglycolate phosphatase activity
ACIPR4_RS20985	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACIPR4_RS21000	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS21005	COG2207	Transcriptional regulator
ACIPR4_RS21010	COG0793	Belongs to the peptidase S41A family
ACIPR4_RS21020	COG0577	efflux transmembrane transporter activity
ACIPR4_RS21030	COG1309	transcriptional regulator
ACIPR4_RS21085	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
ACIPR4_RS21095	COG2271	Major facilitator Superfamily
ACIPR4_RS21100	COG0632	four-way junction helicase activity
ACIPR4_RS21115	COG0366	Alpha amylase catalytic
ACIPR4_RS21120	COG1070	Carbohydrate kinase
ACIPR4_RS21145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACIPR4_RS21165	COG2814	Major facilitator Superfamily
ACIPR4_RS21170	COG0583	DNA-binding transcription factor activity
ACIPR4_RS21185	COG1538	Outer membrane efflux protein
ACIPR4_RS21195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACIPR4_RS21200	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACIPR4_RS21205	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ACIPR4_RS21215	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ACIPR4_RS21230	COG2205	protein histidine kinase activity
ACIPR4_RS21235	COG2205	protein histidine kinase activity
ACIPR4_RS21285	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACIPR4_RS21300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACIPR4_RS21305	COG0594	ribonuclease P activity
ACIPR4_RS21310	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACIPR4_RS21345	COG2203	Gaf domain
ACIPR4_RS21345	COG5001	Diguanylate cyclase
ACIPR4_RS21345	COG3706	GGDEF domain
ACIPR4_RS21345	COG4251	negative regulation of phosphorylation
ACIPR4_RS21350	COG2010	Cytochrome c
ACIPR4_RS21420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACIPR4_RS21425	COG0438	transferase activity, transferring glycosyl groups
ACIPR4_RS21440	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACIPR4_RS21445	COG1214	PFAM Peptidase M22, glycoprotease
ACIPR4_RS21470	COG2207	Transcriptional regulator
ACIPR4_RS21475	COG0515	serine threonine protein kinase
ACIPR4_RS21475	COG2815	serine threonine protein kinase
ACIPR4_RS21500	COG2207	Transcriptional regulator
ACIPR4_RS21525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACIPR4_RS21530	COG4251	negative regulation of phosphorylation
ACIPR4_RS21530	COG5001	Diguanylate cyclase
ACIPR4_RS21530	COG3706	GGDEF domain
ACIPR4_RS21530	COG2203	Gaf domain
ACIPR4_RS21540	COG4191	Histidine kinase
ACIPR4_RS21550	COG3275	phosphorelay sensor kinase activity
ACIPR4_RS21560	COG1858	cytochrome C peroxidase
ACIPR4_RS21585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACIPR4_RS21600	COG0617	tRNA 3'-terminal CCA addition
ACIPR4_RS21610	COG4251	negative regulation of phosphorylation
ACIPR4_RS21620	COG4251	negative regulation of phosphorylation
ACIPR4_RS21620	COG2203	Gaf domain
ACIPR4_RS21620	COG3706	GGDEF domain
ACIPR4_RS21620	COG5001	Diguanylate cyclase
ACIPR4_RS21625	COG1917	Cupin 2, conserved barrel domain protein
ACIPR4_RS21625	COG2207	Transcriptional regulator
ACIPR4_RS21635	COG4372	Transposase
ACIPR4_RS21670	COG4771	TonB-dependent receptor
ACIPR4_RS21690	COG0577	efflux transmembrane transporter activity
ACIPR4_RS21690	COG1136	(ABC) transporter
ACIPR4_RS21695	COG0746	molybdenum cofactor guanylyltransferase activity
ACIPR4_RS21710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACIPR4_RS21725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACIPR4_RS21735	COG3706	GGDEF domain
ACIPR4_RS21750	COG0515	serine threonine protein kinase
ACIPR4_RS21765	COG1309	transcriptional regulator
ACIPR4_RS21770	COG2186	Transcriptional regulator
ACIPR4_RS21775	COG4191	Histidine kinase
ACIPR4_RS21825	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS21830	COG1028	Short-chain dehydrogenase reductase Sdr
ACIPR4_RS21835	COG4251	negative regulation of phosphorylation
ACIPR4_RS21845	COG4191	Histidine kinase
ACIPR4_RS21880	COG1309	transcriptional regulator
ACIPR4_RS21885	COG1191	sigma factor activity
ACIPR4_RS21890	COG5001	Diguanylate cyclase
ACIPR4_RS21890	COG3300	MHYT domain
ACIPR4_RS21925	COG4585	Histidine kinase