locus-tag	class	description
IZ6_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IZ6_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IZ6_RS00030	COG0475	glutathione-regulated potassium exporter activity
IZ6_RS00030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IZ6_RS00035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IZ6_RS00045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IZ6_RS00050	COG1185	polyribonucleotide nucleotidyltransferase activity
IZ6_RS00055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IZ6_RS00060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IZ6_RS00065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IZ6_RS00070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IZ6_RS00080	COG0195	Participates in both transcription termination and antitermination
IZ6_RS00080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IZ6_RS00085	COG0779	Required for maturation of 30S ribosomal subunits
IZ6_RS00090	COG3585	molybdate ion transport
IZ6_RS00105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IZ6_RS00110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IZ6_RS00115	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IZ6_RS00120	COG1253	flavin adenine dinucleotide binding
IZ6_RS00125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IZ6_RS00130	COG1702	phosphate starvation-inducible protein PhoH
IZ6_RS00135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IZ6_RS00150	COG0456	acetyltransferase
IZ6_RS00160	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IZ6_RS00165	COG0180	Tryptophanyl-tRNA synthetase
IZ6_RS00175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IZ6_RS00190	COG0495	leucyl-tRNA aminoacylation
IZ6_RS00215	COG0357	Ribosomal RNA small subunit methyltransferase G
IZ6_RS00220	COG0445	tRNA wobble uridine modification
IZ6_RS00225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IZ6_RS00230	COG1331	Highly conserved protein containing a thioredoxin domain
IZ6_RS00240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IZ6_RS00245	COG1981	membrane
IZ6_RS00250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IZ6_RS00255	COG0424	maF-like protein
IZ6_RS00260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IZ6_RS00265	COG0237	dephospho-CoA kinase activity
IZ6_RS00275	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IZ6_RS00285	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IZ6_RS00315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IZ6_RS00320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IZ6_RS00325	COG0107	imidazoleglycerol-phosphate synthase activity
IZ6_RS00330	COG0140	phosphoribosyl-ATP diphosphatase activity
IZ6_RS00335	COG1072	(Pantothenic acid kinase))
IZ6_RS00370	COG1674	ftsk spoiiie
IZ6_RS00375	COG0004	ammonium transporteR
IZ6_RS00380	COG0347	Belongs to the P(II) protein family
IZ6_RS00385	COG1946	Acyl-CoA thioesterase
IZ6_RS00390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IZ6_RS00395	COG2835	tetraacyldisaccharide 4'-kinase activity
IZ6_RS00400	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IZ6_RS00405	COG3118	belongs to the thioredoxin family
IZ6_RS00415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IZ6_RS00420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IZ6_RS00425	COG1872	DUF167
IZ6_RS00450	COG2200	EAL domain
IZ6_RS00460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IZ6_RS00465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IZ6_RS00475	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IZ6_RS00485	COG0837	glucose binding
IZ6_RS00490	COG0564	pseudouridine synthase activity
IZ6_RS00495	COG1597	lipid kinase activity
IZ6_RS00515	COG0784	Response regulator, receiver
IZ6_RS00530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IZ6_RS00540	COG3045	CreA protein
IZ6_RS00555	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IZ6_RS00560	COG1238	metal cluster binding
IZ6_RS00595	COG0477	Major facilitator Superfamily
IZ6_RS00620	COG2271	Major facilitator Superfamily
IZ6_RS00630	COG0840	transmembrane signaling receptor activity
IZ6_RS00635	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IZ6_RS00640	COG0140	phosphoribosyl-ATP diphosphatase activity
IZ6_RS00645	COG1253	flavin adenine dinucleotide binding
IZ6_RS00650	COG2308	Evidence 4 Homologs of previously reported genes of
IZ6_RS00660	COG1305	Transglutaminase-like
IZ6_RS00670	COG1902	pentaerythritol trinitrate reductase activity
IZ6_RS00680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IZ6_RS00705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IZ6_RS00710	COG1360	Flagellar Motor Protein
IZ6_RS00730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IZ6_RS00740	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IZ6_RS00745	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IZ6_RS00750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IZ6_RS00755	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IZ6_RS00760	COG0799	negative regulation of ribosome biogenesis
IZ6_RS00765	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IZ6_RS00775	COG0793	Belongs to the peptidase S41A family
IZ6_RS00785	COG0494	nUDIX hydrolase
IZ6_RS00790	COG0494	nUDIX hydrolase
IZ6_RS00795	COG0351	phosphomethylpyrimidine kinase
IZ6_RS00795	COG0352	thiamine-phosphate diphosphorylase activity
IZ6_RS00795	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IZ6_RS00800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IZ6_RS00810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IZ6_RS00815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IZ6_RS00820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IZ6_RS00825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IZ6_RS00840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IZ6_RS00845	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IZ6_RS00855	COG1253	flavin adenine dinucleotide binding
IZ6_RS00860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IZ6_RS00870	COG0508	dehydrogenase complex catalyzes the overall conversion of
IZ6_RS00875	COG0567	Dehydrogenase, E1 component
IZ6_RS00880	COG0039	L-malate dehydrogenase activity
IZ6_RS00885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IZ6_RS00910	COG1053	succinate dehydrogenase
IZ6_RS00930	COG0288	reversible hydration of carbon dioxide
IZ6_RS00935	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IZ6_RS00945	COG0473	3-isopropylmalate dehydrogenase activity
IZ6_RS00965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IZ6_RS00970	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IZ6_RS00975	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
IZ6_RS00980	COG0066	3-isopropylmalate dehydratase activity
IZ6_RS00995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IZ6_RS01000	COG0335	large ribosomal subunit rRNA binding
IZ6_RS01010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IZ6_RS01015	COG0228	four-way junction DNA binding
IZ6_RS01020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IZ6_RS01035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IZ6_RS01040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IZ6_RS01045	COG0552	protein localization to endoplasmic reticulum
IZ6_RS01050	COG2917	probably involved in intracellular septation
IZ6_RS01055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IZ6_RS01065	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IZ6_RS01070	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IZ6_RS01075	COG4133	protoheme IX ABC transporter activity
IZ6_RS01080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IZ6_RS01105	COG0670	Belongs to the BI1 family
IZ6_RS01110	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IZ6_RS01115	COG4181	ATPase activity
IZ6_RS01125	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IZ6_RS01130	COG2154	pterin-4-alpha-carbinolamine dehydratase
IZ6_RS01145	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IZ6_RS01155	COG1704	LemA family
IZ6_RS01160	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IZ6_RS01170	COG2902	Dehydrogenase
IZ6_RS01185	COG0138	bifunctional purine biosynthesis protein purh
IZ6_RS01200	COG0501	Belongs to the peptidase M48B family
IZ6_RS01215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IZ6_RS01220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IZ6_RS01230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IZ6_RS01235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IZ6_RS01240	COG0181	hydroxymethylbilane synthase activity
IZ6_RS01255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IZ6_RS01280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IZ6_RS01285	COG2084	Dehydrogenase
IZ6_RS01290	COG3622	Belongs to the hyi family
IZ6_RS01295	COG3960	tartronate-semialdehyde synthase activity
IZ6_RS01320	COG1802	Transcriptional regulator
IZ6_RS01335	COG0179	Fumarylacetoacetate (FAA) hydrolase
IZ6_RS01340	COG0469	pyruvate kinase activity
IZ6_RS01375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IZ6_RS01400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IZ6_RS01400	COG2813	Specifically methylates the guanine in position
IZ6_RS01405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IZ6_RS01415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IZ6_RS01420	COG0287	Prephenate dehydrogenase
IZ6_RS01430	COG2153	protein acetylation
IZ6_RS01450	COG2884	Cell division ATP-binding protein ftsE
IZ6_RS01460	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IZ6_RS01465	COG2204	response regulator
IZ6_RS01475	COG0019	diaminopimelate decarboxylase activity
IZ6_RS01485	COG0165	Argininosuccinate lyase
IZ6_RS01490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IZ6_RS01515	COG1250	3-hydroxyacyl-CoA dehydrogenase
IZ6_RS01565	COG0271	Belongs to the BolA IbaG family
IZ6_RS01590	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IZ6_RS01595	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IZ6_RS01645	COG0492	ferredoxin-NADP+ reductase activity
IZ6_RS01670	COG1012	belongs to the aldehyde dehydrogenase family
IZ6_RS01675	COG3181	Tripartite tricarboxylate transporter family receptor
IZ6_RS01690	COG2814	Major facilitator Superfamily
IZ6_RS01705	COG4948	Mandelate Racemase Muconate Lactonizing
IZ6_RS01720	COG0179	Fumarylacetoacetate (FAA) hydrolase
IZ6_RS01740	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS01770	COG2186	Transcriptional regulator
IZ6_RS01780	COG0737	Belongs to the 5'-nucleotidase family
IZ6_RS01790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IZ6_RS01795	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
IZ6_RS01800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IZ6_RS01810	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IZ6_RS01810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IZ6_RS01820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IZ6_RS01835	COG0251	oxidation-reduction process
IZ6_RS01840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IZ6_RS01845	COG0765	amino acid transport
IZ6_RS01850	COG0765	amino acid transport
IZ6_RS01860	COG3665	Urea carboxylase-associated protein
IZ6_RS01870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IZ6_RS01920	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IZ6_RS01925	COG4948	Mandelate Racemase Muconate Lactonizing
IZ6_RS01950	COG0745	RESPONSE REGULATOR receiver
IZ6_RS01955	COG0247	lactate metabolic process
IZ6_RS01955	COG0277	FAD linked oxidase domain protein
IZ6_RS01960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IZ6_RS01965	COG1802	Transcriptional regulator
IZ6_RS01980	COG3181	Tripartite tricarboxylate transporter family receptor
IZ6_RS02005	COG1396	sequence-specific DNA binding
IZ6_RS02015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IZ6_RS02020	COG1116	anion transmembrane transporter activity
IZ6_RS02025	COG4521	taurine ABC transporter
IZ6_RS02030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IZ6_RS02035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IZ6_RS02040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IZ6_RS02060	COG4566	intracellular signal transduction
IZ6_RS02065	COG4191	Histidine kinase
IZ6_RS02070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IZ6_RS02085	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IZ6_RS02095	COG2226	methyltransferase
IZ6_RS02100	COG0110	maltose O-acetyltransferase activity
IZ6_RS02105	COG2188	Transcriptional regulator
IZ6_RS02110	COG3624	Phosphonate C-P lyase system protein PhnG
IZ6_RS02115	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IZ6_RS02120	COG3626	phosphonate metabolism
IZ6_RS02125	COG3627	carbon phosphorus lyase activity
IZ6_RS02130	COG4107	phosphonate C-P lyase system protein PhnK
IZ6_RS02135	COG4778	phosphonate C-P lyase system protein PhnL
IZ6_RS02140	COG3454	Phosphonate metabolism
IZ6_RS02145	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IZ6_RS02155	COG3639	organic phosphonate transmembrane transporter activity
IZ6_RS02160	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IZ6_RS02165	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IZ6_RS02170	COG0366	Alpha amylase catalytic
IZ6_RS02175	COG1959	2 iron, 2 sulfur cluster binding
IZ6_RS02190	COG1196	nuclear chromosome segregation
IZ6_RS02190	COG3264	Mechanosensitive ion channel
IZ6_RS02195	COG2340	Cysteine-rich secretory protein family
IZ6_RS02205	COG0523	cobalamin synthesis protein
IZ6_RS02210	COG0318	PFAM AMP-dependent synthetase and ligase
IZ6_RS02220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IZ6_RS02230	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IZ6_RS02235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IZ6_RS02245	COG4974	Belongs to the 'phage' integrase family
IZ6_RS02250	COG0825	malonyl-CoA metabolic process
IZ6_RS02255	COG3034	peptidoglycan biosynthetic process
IZ6_RS02260	COG0653	protein targeting
IZ6_RS02265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IZ6_RS02270	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IZ6_RS02275	COG0494	nUDIX hydrolase
IZ6_RS02290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IZ6_RS02295	COG1040	competence protein
IZ6_RS02305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IZ6_RS02320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IZ6_RS02325	COG0527	aspartate kinase activity
IZ6_RS02335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IZ6_RS02340	COG2890	protein-(glutamine-N5) methyltransferase activity
IZ6_RS02375	COG0739	heme binding
IZ6_RS02430	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IZ6_RS02475	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IZ6_RS02500	COG1121	(ABC) transporter
IZ6_RS02505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IZ6_RS02515	COG0523	cobalamin synthesis protein
IZ6_RS02540	COG5310	Homospermidine synthase
IZ6_RS02555	COG3153	acetyltransferase
IZ6_RS02575	COG3454	Phosphonate metabolism
IZ6_RS02580	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IZ6_RS02590	COG1914	H( )-stimulated, divalent metal cation uptake system
IZ6_RS02595	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IZ6_RS02625	COG0725	ABC transporter, periplasmic molybdate-binding protein
IZ6_RS02630	COG4149	molybdate abc transporter
IZ6_RS02635	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IZ6_RS02650	COG0483	inositol monophosphate 1-phosphatase activity
IZ6_RS02725	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IZ6_RS02730	COG0067	glutamate synthase
IZ6_RS02730	COG0069	glutamate synthase activity
IZ6_RS02730	COG0070	glutamate synthase
IZ6_RS02750	COG2951	lytic endotransglycosylase activity
IZ6_RS02760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IZ6_RS02770	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IZ6_RS02770	COG0517	IMP dehydrogenase activity
IZ6_RS02775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IZ6_RS02785	COG1585	Membrane protein implicated in regulation of membrane protease activity
IZ6_RS02790	COG0330	HflC and HflK could
IZ6_RS02795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IZ6_RS02800	COG0457	Tetratricopeptide repeat
IZ6_RS02820	COG3750	Belongs to the UPF0335 family
IZ6_RS02825	COG3108	Peptidase M15
IZ6_RS02830	COG2989	Protein conserved in bacteria
IZ6_RS02880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IZ6_RS02900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IZ6_RS02905	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IZ6_RS02920	COG1132	(ABC) transporter
IZ6_RS02925	COG0254	rRNA binding
IZ6_RS02955	COG0483	inositol monophosphate 1-phosphatase activity
IZ6_RS02985	COG1278	Cold shock
IZ6_RS03025	COG0126	phosphoglycerate kinase activity
IZ6_RS03065	COG1692	metallophosphoesterase
IZ6_RS03075	COG0217	transcriptional regulatory protein
IZ6_RS03080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IZ6_RS03085	COG0632	four-way junction helicase activity
IZ6_RS03090	COG2255	four-way junction helicase activity
IZ6_RS03095	COG0824	Thioesterase
IZ6_RS03120	COG1309	transcriptional regulator
IZ6_RS03145	COG0823	Involved in the tonB-independent uptake of proteins
IZ6_RS03150	COG3663	DNA glycosylase
IZ6_RS03155	COG2885	chlorophyll binding
IZ6_RS03170	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IZ6_RS03175	COG0037	tRNA processing
IZ6_RS03180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IZ6_RS03190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IZ6_RS03195	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IZ6_RS03205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IZ6_RS03210	COG0443	Heat shock 70 kDa protein
IZ6_RS03215	COG0697	spore germination
IZ6_RS03220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IZ6_RS03230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IZ6_RS03235	COG0564	pseudouridine synthase activity
IZ6_RS03245	COG1846	Transcriptional regulator
IZ6_RS03250	COG1764	response to oxidative stress
IZ6_RS03270	COG0179	Fumarylacetoacetate (FAA) hydrolase
IZ6_RS03275	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS03325	COG1349	DNA-binding transcription factor activity
IZ6_RS03335	COG1177	transmembrane transport
IZ6_RS03340	COG1177	transmembrane transport
IZ6_RS03345	COG3842	ATPase activity
IZ6_RS03355	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS03360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IZ6_RS03370	COG2267	carboxylic ester hydrolase activity
IZ6_RS03410	COG2188	Transcriptional regulator
IZ6_RS03430	COG1012	belongs to the aldehyde dehydrogenase family
IZ6_RS03450	COG2267	carboxylic ester hydrolase activity
IZ6_RS03465	COG0179	Fumarylacetoacetate (FAA) hydrolase
IZ6_RS03485	COG2188	Transcriptional regulator
IZ6_RS03505	COG1392	Phosphate transport regulator
IZ6_RS03510	COG0306	phosphate transporter
IZ6_RS03520	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IZ6_RS03550	COG2198	Histidine kinase
IZ6_RS03550	COG0784	Response regulator, receiver
IZ6_RS03550	COG0643	Histidine kinase
IZ6_RS03560	COG0745	RESPONSE REGULATOR receiver
IZ6_RS03565	COG2201	protein-glutamate methylesterase activity
IZ6_RS03595	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IZ6_RS03605	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IZ6_RS03610	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IZ6_RS03615	COG3300	MHYT domain
IZ6_RS03615	COG5001	Diguanylate cyclase
IZ6_RS03620	COG2204	response regulator
IZ6_RS03625	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IZ6_RS03635	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IZ6_RS03640	COG1766	The M ring may be actively involved in energy transduction
IZ6_RS03655	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IZ6_RS03660	COG0482	sulfurtransferase activity
IZ6_RS03665	COG2226	methyltransferase
IZ6_RS03675	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IZ6_RS03680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IZ6_RS03725	COG1396	sequence-specific DNA binding
IZ6_RS03940	COG3179	chitinase
IZ6_RS03980	COG0583	DNA-binding transcription factor activity
IZ6_RS03985	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IZ6_RS03995	COG3383	formate dehydrogenase (NAD+) activity
IZ6_RS04010	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IZ6_RS04015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IZ6_RS04045	COG0784	Response regulator, receiver
IZ6_RS04050	COG4565	transcriptional regulatory protein
IZ6_RS04065	COG1509	lysine 2,3-aminomutase activity
IZ6_RS04070	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IZ6_RS04075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IZ6_RS04100	COG0494	nUDIX hydrolase
IZ6_RS04115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IZ6_RS04120	COG0435	Glutathione S-transferase
IZ6_RS04150	COG0714	Associated with various cellular activities
IZ6_RS04160	COG0617	tRNA 3'-terminal CCA addition
IZ6_RS04175	COG0408	coproporphyrinogen oxidase activity
IZ6_RS04185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IZ6_RS04185	COG2857	Cytochrome c1
IZ6_RS04190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IZ6_RS04190	COG2857	Cytochrome c1
IZ6_RS04195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IZ6_RS04200	COG1515	deoxyribonuclease V activity
IZ6_RS04205	COG0012	GTP binding
IZ6_RS04210	COG0193	aminoacyl-tRNA hydrolase activity
IZ6_RS04220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IZ6_RS04230	COG1496	oxidoreductase activity
IZ6_RS04240	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IZ6_RS04270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IZ6_RS04280	COG0745	RESPONSE REGULATOR receiver
IZ6_RS04285	COG1846	Transcriptional regulator
IZ6_RS04290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IZ6_RS04310	COG0314	molybdopterin synthase activity
IZ6_RS04320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IZ6_RS04325	COG0322	excinuclease ABC activity
IZ6_RS04345	COG0625	glutathione transferase activity
IZ6_RS04350	COG1278	Cold shock
IZ6_RS04355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IZ6_RS04365	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IZ6_RS04395	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IZ6_RS04425	COG0556	nucleotide-excision repair
IZ6_RS04440	COG1678	Uncharacterized ACR, COG1678
IZ6_RS04450	COG0678	peroxiredoxin activity
IZ6_RS04460	COG0328	RNA-DNA hybrid ribonuclease activity
IZ6_RS04465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IZ6_RS04475	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IZ6_RS04485	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IZ6_RS04490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IZ6_RS04495	COG1194	a g-specific adenine glycosylase
IZ6_RS04505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IZ6_RS04510	COG1196	nuclear chromosome segregation
IZ6_RS04520	COG0356	it plays a direct role in the translocation of protons across the membrane
IZ6_RS04530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IZ6_RS04535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IZ6_RS04590	COG2321	neutral zinc metallopeptidase
IZ6_RS04595	COG1294	oxidase, subunit
IZ6_RS04600	COG1271	oxidase subunit
IZ6_RS04610	COG1573	uracil-dna glycosylase
IZ6_RS04620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IZ6_RS04625	COG0142	geranyltranstransferase activity
IZ6_RS04655	COG0752	glycyl-tRNA synthetase alpha subunit
IZ6_RS04660	COG0751	glycine-tRNA ligase activity
IZ6_RS04695	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IZ6_RS04700	COG0519	Catalyzes the synthesis of GMP from XMP
IZ6_RS04710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IZ6_RS04740	COG1051	belongs to the nudix hydrolase family
IZ6_RS04750	COG0277	FAD linked oxidase domain protein
IZ6_RS04755	COG1280	lysine exporter protein (LysE YggA)
IZ6_RS04760	COG0009	L-threonylcarbamoyladenylate synthase
IZ6_RS04765	COG0123	including yeast histone deacetylase and acetoin utilization protein
IZ6_RS04770	COG1722	exodeoxyribonuclease VII activity
IZ6_RS04775	COG0598	Magnesium transport protein CorA
IZ6_RS04780	COG3300	MHYT domain
IZ6_RS04780	COG5001	Diguanylate cyclase
IZ6_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS04790	COG0259	pyridoxamine-phosphate oxidase activity
IZ6_RS04805	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IZ6_RS04820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IZ6_RS04825	COG0656	L-ascorbic acid biosynthetic process
IZ6_RS04835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IZ6_RS04885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IZ6_RS04890	COG0116	Belongs to the methyltransferase superfamily
IZ6_RS04890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IZ6_RS04895	COG2373	Large extracellular alpha-helical protein
IZ6_RS04900	COG4953	penicillin-binding protein 1C
IZ6_RS04905	COG0604	alcohol dehydrogenase
IZ6_RS04905	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS04905	COG3321	synthase
IZ6_RS04930	COG1802	Transcriptional regulator
IZ6_RS04940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IZ6_RS04945	COG0045	succinate-CoA ligase (ADP-forming) activity
IZ6_RS04950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IZ6_RS04970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IZ6_RS04975	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IZ6_RS04975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IZ6_RS04980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IZ6_RS04990	COG0433	COG0433 Predicted ATPase
IZ6_RS05010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IZ6_RS05020	COG4957	zinc ion binding
IZ6_RS05025	COG2166	iron-sulfur cluster assembly
IZ6_RS05035	COG2205	protein histidine kinase activity
IZ6_RS05070	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IZ6_RS05075	COG2983	Belongs to the UPF0260 family
IZ6_RS05135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IZ6_RS05135	COG0446	pyridine nucleotide-disulphide oxidoreductase
IZ6_RS05145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IZ6_RS05150	COG4235	cytochrome complex assembly
IZ6_RS05155	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IZ6_RS05160	COG1138	Cytochrome C-type biogenesis protein
IZ6_RS05165	COG3088	subunit of a heme lyase
IZ6_RS05175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IZ6_RS05185	COG2205	protein histidine kinase activity
IZ6_RS05190	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IZ6_RS05195	COG2205	protein histidine kinase activity
IZ6_RS05195	COG2202	Pas domain
IZ6_RS05200	COG0308	aminopeptidase N
IZ6_RS05205	COG0628	permease
IZ6_RS05225	COG2205	protein histidine kinase activity
IZ6_RS05225	COG2202	Pas domain
IZ6_RS05230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IZ6_RS05235	COG0489	protein tyrosine kinase activity
IZ6_RS05240	COG1877	trehalose-phosphatase activity
IZ6_RS05245	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IZ6_RS05265	COG1396	sequence-specific DNA binding
IZ6_RS05270	COG0583	DNA-binding transcription factor activity
IZ6_RS05335	COG0730	response to heat
IZ6_RS05385	COG3685	Protein conserved in bacteria
IZ6_RS05405	COG1295	ribonuclease BN
IZ6_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS05590	COG1376	ErfK ybiS ycfS ynhG family protein
IZ6_RS05595	COG0546	phosphoglycolate phosphatase activity
IZ6_RS05605	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IZ6_RS05630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IZ6_RS05635	COG0840	transmembrane signaling receptor activity
IZ6_RS05645	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IZ6_RS05670	COG0215	cysteine-tRNA ligase activity
IZ6_RS05680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IZ6_RS05690	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IZ6_RS05720	COG3842	ATPase activity
IZ6_RS05755	COG5265	(ABC) transporter
IZ6_RS05760	COG0688	phosphatidylethanolamine metabolic process
IZ6_RS05765	COG1183	phosphatidylcholine synthase activity
IZ6_RS05795	COG2010	Cytochrome c
IZ6_RS05805	COG0346	lactoylglutathione lyase activity
IZ6_RS05855	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS05860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IZ6_RS05865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IZ6_RS05875	COG0431	NADPH-dependent FMN reductase
IZ6_RS05915	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS05955	COG0596	Alpha beta hydrolase
IZ6_RS05960	COG2079	MmgE PrpD family protein
IZ6_RS05965	COG0473	3-isopropylmalate dehydrogenase activity
IZ6_RS05970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IZ6_RS05975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IZ6_RS05990	COG1595	DNA-templated transcription, initiation
IZ6_RS06035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IZ6_RS06050	COG0741	lytic transglycosylase activity
IZ6_RS06055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IZ6_RS06060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IZ6_RS06065	COG1573	uracil-dna glycosylase
IZ6_RS06075	COG1758	RNA polymerase activity
IZ6_RS06085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IZ6_RS06095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IZ6_RS06100	COG0736	holo-[acyl-carrier-protein] synthase activity
IZ6_RS06110	COG0571	ribonuclease III activity
IZ6_RS06115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IZ6_RS06120	COG1381	Involved in DNA repair and RecF pathway recombination
IZ6_RS06125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IZ6_RS06145	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IZ6_RS06150	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IZ6_RS06155	COG0154	amidase activity
IZ6_RS06175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IZ6_RS06195	COG0625	glutathione transferase activity
IZ6_RS06245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IZ6_RS06250	COG1127	ABC transporter
IZ6_RS06255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IZ6_RS06255	COG3218	ABC-type transport auxiliary lipoprotein component
IZ6_RS06265	COG2186	Transcriptional regulator
IZ6_RS06275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IZ6_RS06280	COG1116	anion transmembrane transporter activity
IZ6_RS06285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IZ6_RS06295	COG0473	3-isopropylmalate dehydrogenase activity
IZ6_RS06305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IZ6_RS06315	COG5002	protein histidine kinase activity
IZ6_RS06330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IZ6_RS06340	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS06360	COG0010	Belongs to the arginase family
IZ6_RS06395	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IZ6_RS06455	COG2205	protein histidine kinase activity
IZ6_RS06460	COG0625	glutathione transferase activity
IZ6_RS06470	COG4566	intracellular signal transduction
IZ6_RS06475	COG4566	intracellular signal transduction
IZ6_RS06480	COG4566	intracellular signal transduction
IZ6_RS06485	COG4191	Histidine kinase
IZ6_RS06540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IZ6_RS06570	COG4771	TonB-dependent receptor
IZ6_RS06585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IZ6_RS06590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IZ6_RS06595	COG1120	ATPase activity
IZ6_RS06610	COG0784	Response regulator, receiver
IZ6_RS06610	COG2198	Histidine kinase
IZ6_RS06610	COG5002	protein histidine kinase activity
IZ6_RS06630	COG1129	ABC transporter
IZ6_RS06665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IZ6_RS06695	COG0584	glycerophosphoryl diester phosphodiesterase
IZ6_RS06720	COG0436	Aminotransferase
IZ6_RS06725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IZ6_RS06730	COG0463	Glycosyl transferase, family 2
IZ6_RS06740	COG0113	porphobilinogen synthase activity
IZ6_RS06750	COG1846	Transcriptional regulator
IZ6_RS06755	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS06760	COG4221	oxidoreductase activity
IZ6_RS06765	COG2207	Transcriptional regulator
IZ6_RS06815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IZ6_RS06820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IZ6_RS06825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IZ6_RS06825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IZ6_RS06835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IZ6_RS06840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IZ6_RS06845	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IZ6_RS06855	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IZ6_RS06860	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IZ6_RS06880	COG0416	fatty acid biosynthetic process
IZ6_RS06885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IZ6_RS06915	COG0625	glutathione transferase activity
IZ6_RS06930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IZ6_RS06935	COG4948	Mandelate Racemase Muconate Lactonizing
IZ6_RS06960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IZ6_RS06965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IZ6_RS06970	COG2368	4-hydroxyphenylacetate
IZ6_RS06975	COG0583	DNA-binding transcription factor activity
IZ6_RS06980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IZ6_RS06990	COG1937	Protein conserved in bacteria
IZ6_RS07010	COG0728	peptidoglycan biosynthetic process
IZ6_RS07030	COG0297	glycogen (starch) synthase activity
IZ6_RS07055	COG1612	heme a metabolic process
IZ6_RS07110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IZ6_RS07125	COG0525	valine-tRNA ligase activity
IZ6_RS07135	COG1280	lysine exporter protein (LysE YggA)
IZ6_RS07175	COG0129	dihydroxy-acid dehydratase activity
IZ6_RS07200	COG0316	Belongs to the HesB IscA family
IZ6_RS07205	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IZ6_RS07210	COG0018	arginyl-trna synthetase
IZ6_RS07220	COG1472	Belongs to the glycosyl hydrolase 3 family
IZ6_RS07225	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IZ6_RS07230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IZ6_RS07235	COG3842	ATPase activity
IZ6_RS07240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IZ6_RS07245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IZ6_RS07250	COG0805	protein transport
IZ6_RS07255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IZ6_RS07260	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IZ6_RS07265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IZ6_RS07285	COG0316	Belongs to the HesB IscA family
IZ6_RS07295	COG0513	Belongs to the DEAD box helicase family
IZ6_RS07310	COG0187	DNA topoisomerase II activity
IZ6_RS07320	COG0174	glutamine synthetase
IZ6_RS07325	COG0347	Belongs to the P(II) protein family
IZ6_RS07335	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IZ6_RS07335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IZ6_RS07340	COG2132	Multicopper oxidase
IZ6_RS07350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IZ6_RS07360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IZ6_RS07360	COG2169	Transcriptional regulator
IZ6_RS07375	COG0544	peptidyl-prolyl cis-trans isomerase activity
IZ6_RS07380	COG0740	serine-type endopeptidase activity
IZ6_RS07385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IZ6_RS07390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IZ6_RS07395	COG0776	regulation of translation
IZ6_RS07425	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IZ6_RS07430	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IZ6_RS07435	COG0649	NAD binding
IZ6_RS07445	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IZ6_RS07455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IZ6_RS07460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IZ6_RS07470	COG0713	ATP synthesis coupled electron transport
IZ6_RS07485	COG1007	ATP synthesis coupled electron transport
IZ6_RS07510	COG0442	prolyl-tRNA aminoacylation
IZ6_RS07520	COG1136	(ABC) transporter
IZ6_RS07540	COG0052	Belongs to the universal ribosomal protein uS2 family
IZ6_RS07545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IZ6_RS07550	COG0528	UMP kinase activity
IZ6_RS07560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IZ6_RS07570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IZ6_RS07575	COG0750	zinc metalloprotease
IZ6_RS07585	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IZ6_RS07590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IZ6_RS07595	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IZ6_RS07600	COG3494	Protein of unknown function (DUF1009)
IZ6_RS07605	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IZ6_RS07615	COG0372	Belongs to the citrate synthase family
IZ6_RS07620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IZ6_RS07630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IZ6_RS07645	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IZ6_RS07650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IZ6_RS07665	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
IZ6_RS07680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IZ6_RS07690	COG0629	single-stranded DNA binding
IZ6_RS07700	COG0626	cystathionine gamma-synthase activity
IZ6_RS07705	COG0628	permease
IZ6_RS07710	COG2897	thiosulfate sulfurtransferase activity
IZ6_RS07720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IZ6_RS07725	COG1278	Cold shock
IZ6_RS07740	COG2201	protein-glutamate methylesterase activity
IZ6_RS07750	COG1393	Belongs to the ArsC family
IZ6_RS07770	COG2169	Transcriptional regulator
IZ6_RS07770	COG1917	Cupin 2, conserved barrel domain protein
IZ6_RS07775	COG4106	trans-aconitate 2-methyltransferase activity
IZ6_RS07780	COG0519	Catalyzes the synthesis of GMP from XMP
IZ6_RS07780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IZ6_RS07785	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IZ6_RS07810	COG0477	Major facilitator Superfamily
IZ6_RS07820	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IZ6_RS07825	COG0248	Ppx GppA phosphatase
IZ6_RS07850	COG1160	GTP binding
IZ6_RS07855	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS07860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IZ6_RS07885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IZ6_RS07890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IZ6_RS07895	COG0305	Participates in initiation and elongation during chromosome replication
IZ6_RS07900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IZ6_RS07905	COG0359	binds to the 23S rRNA
IZ6_RS07915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IZ6_RS07920	COG0360	Binds together with S18 to 16S ribosomal RNA
IZ6_RS07950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IZ6_RS07955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IZ6_RS07960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IZ6_RS07965	COG1561	YicC-like family, N-terminal region
IZ6_RS07970	COG0194	GDP metabolic process
IZ6_RS07975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IZ6_RS08000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IZ6_RS08020	COG0488	(ABC) transporter
IZ6_RS08030	COG0105	UTP biosynthetic process
IZ6_RS08035	COG0861	Integral membrane protein TerC family
IZ6_RS08045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IZ6_RS08050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IZ6_RS08065	COG0628	permease
IZ6_RS08075	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IZ6_RS08080	COG0248	Ppx GppA phosphatase
IZ6_RS08090	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IZ6_RS08095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IZ6_RS08100	COG0280	phosphate acetyltransferase
IZ6_RS08100	COG0281	malic enzyme
IZ6_RS08105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IZ6_RS08110	COG2200	EAL domain
IZ6_RS08110	COG2771	luxR family
IZ6_RS08120	COG1832	CoA-binding protein
IZ6_RS08135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IZ6_RS08140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IZ6_RS08145	COG0010	Belongs to the arginase family
IZ6_RS08160	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IZ6_RS08165	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IZ6_RS08170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IZ6_RS08195	COG0436	Aminotransferase
IZ6_RS08205	COG1494	fructose-1,6-bisphosphatase
IZ6_RS08210	COG1960	acyl-CoA dehydrogenase activity
IZ6_RS08215	COG0183	Belongs to the thiolase family
IZ6_RS08225	COG0427	acetyl-CoA hydrolase
IZ6_RS08230	COG0492	ferredoxin-NADP+ reductase activity
IZ6_RS08235	COG0488	(ABC) transporter
IZ6_RS08270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IZ6_RS08280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IZ6_RS08305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IZ6_RS08310	COG0343	queuine tRNA-ribosyltransferase activity
IZ6_RS08315	COG1802	Transcriptional regulator
IZ6_RS08320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IZ6_RS08325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IZ6_RS08345	COG0492	ferredoxin-NADP+ reductase activity
IZ6_RS08350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IZ6_RS08355	COG0573	inorganic phosphate transmembrane transporter activity
IZ6_RS08360	COG0573	inorganic phosphate transmembrane transporter activity
IZ6_RS08365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IZ6_RS08370	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IZ6_RS08375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IZ6_RS08380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IZ6_RS08385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IZ6_RS08420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IZ6_RS08425	COG1280	lysine exporter protein (LysE YggA)
IZ6_RS08430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IZ6_RS08435	COG1280	lysine exporter protein (LysE YggA)
IZ6_RS08445	COG2832	Protein of unknown function (DUF454)
IZ6_RS08455	COG1404	Belongs to the peptidase S8 family
IZ6_RS08475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IZ6_RS08485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IZ6_RS08495	COG4166	transmembrane transport
IZ6_RS08510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IZ6_RS08515	COG1183	phosphatidylcholine synthase activity
IZ6_RS08525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IZ6_RS08535	COG3685	Protein conserved in bacteria
IZ6_RS08540	COG0784	Response regulator, receiver
IZ6_RS08540	COG4191	Histidine kinase
IZ6_RS08545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IZ6_RS08570	COG0745	RESPONSE REGULATOR receiver
IZ6_RS08575	COG0642	Histidine kinase
IZ6_RS08580	COG2226	methyltransferase
IZ6_RS08595	COG0628	permease
IZ6_RS08605	COG2235	arginine
IZ6_RS08610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IZ6_RS08615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IZ6_RS08665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IZ6_RS08690	COG0786	glutamate:sodium symporter activity
IZ6_RS08710	COG3300	MHYT domain
IZ6_RS08710	COG5001	Diguanylate cyclase
IZ6_RS08725	COG1686	Belongs to the peptidase S11 family
IZ6_RS08730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IZ6_RS08745	COG0084	hydrolase, TatD family'
IZ6_RS08750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IZ6_RS08750	COG0321	lipoyl(octanoyl) transferase activity
IZ6_RS08765	COG2514	catechol 2,3-dioxygenase activity
IZ6_RS08775	COG2258	MOSC domain
IZ6_RS08785	COG0463	Glycosyl transferase, family 2
IZ6_RS08790	COG3956	TIGRFAM MazG family protein
IZ6_RS08795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IZ6_RS08800	COG1923	regulation of RNA biosynthetic process
IZ6_RS08805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IZ6_RS08810	COG0569	domain protein
IZ6_RS08815	COG2204	response regulator
IZ6_RS08820	COG5000	phosphorelay sensor kinase activity
IZ6_RS08825	COG2204	response regulator
IZ6_RS08840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IZ6_RS08840	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IZ6_RS08845	COG1058	Belongs to the CinA family
IZ6_RS08845	COG1546	Belongs to the CinA family
IZ6_RS08860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IZ6_RS08880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IZ6_RS08885	COG0508	dehydrogenase complex catalyzes the overall conversion of
IZ6_RS08890	COG0022	dehydrogenase e1 component
IZ6_RS08890	COG0508	dehydrogenase complex catalyzes the overall conversion of
IZ6_RS08895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IZ6_RS08910	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IZ6_RS08920	COG0148	phosphopyruvate hydratase activity
IZ6_RS08940	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IZ6_RS08955	COG0149	triose-phosphate isomerase activity
IZ6_RS08960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IZ6_RS08965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IZ6_RS08970	COG3214	Protein conserved in bacteria
IZ6_RS08980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IZ6_RS08995	COG0134	indole-3-glycerol-phosphate synthase activity
IZ6_RS09000	COG0315	cyclic pyranopterin monophosphate synthase activity
IZ6_RS09005	COG0303	'Molybdopterin
IZ6_RS09010	COG0352	thiamine-phosphate diphosphorylase activity
IZ6_RS09015	COG2022	thiamine diphosphate biosynthetic process
IZ6_RS09025	COG2022	thiamine diphosphate biosynthetic process
IZ6_RS09025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IZ6_RS09035	COG3737	Protein of unknown function (DUF498/DUF598)
IZ6_RS09045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IZ6_RS09050	COG1862	Preprotein translocase
IZ6_RS09090	COG2151	metal-sulfur cluster biosynthetic enzyme
IZ6_RS09095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IZ6_RS09100	COG0719	Fe-S assembly protein
IZ6_RS09105	COG0396	ATPase activity
IZ6_RS09110	COG0719	Fe-S assembly protein
IZ6_RS09115	COG1104	cysteine desulfurase activity
IZ6_RS09120	COG2945	thiolester hydrolase activity
IZ6_RS09130	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IZ6_RS09135	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IZ6_RS09140	COG2852	Protein conserved in bacteria
IZ6_RS09145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IZ6_RS09155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IZ6_RS09160	COG0739	heme binding
IZ6_RS09180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IZ6_RS09185	COG0860	N-Acetylmuramoyl-L-alanine amidase
IZ6_RS09190	COG1530	ribonuclease E activity
IZ6_RS09195	COG0436	Aminotransferase
IZ6_RS09210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IZ6_RS09215	COG0511	ligase activity, forming carbon-carbon bonds
IZ6_RS09220	COG0439	Biotin carboxylase
IZ6_RS09225	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IZ6_RS09230	COG3706	GGDEF domain
IZ6_RS09260	COG0784	Response regulator, receiver
IZ6_RS09260	COG4191	Histidine kinase
IZ6_RS09270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IZ6_RS09275	COG0640	Transcriptional regulator
IZ6_RS09280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IZ6_RS09285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IZ6_RS09305	COG0540	Belongs to the ATCase OTCase family
IZ6_RS09320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IZ6_RS09320	COG0758	DNA mediated transformation
IZ6_RS09330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IZ6_RS09335	COG0557	exoribonuclease II activity
IZ6_RS09350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IZ6_RS09360	COG0784	Response regulator, receiver
IZ6_RS09370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IZ6_RS09390	COG0537	adenosine 5'-monophosphoramidase activity
IZ6_RS09395	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS09405	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IZ6_RS09420	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IZ6_RS09460	COG3158	transport of potassium into the cell
IZ6_RS09465	COG2239	Acts as a magnesium transporter
IZ6_RS09490	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IZ6_RS09530	COG2197	response regulator
IZ6_RS09535	COG1254	Belongs to the acylphosphatase family
IZ6_RS09540	COG0321	lipoyl(octanoyl) transferase activity
IZ6_RS09570	COG0546	phosphoglycolate phosphatase activity
IZ6_RS09575	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IZ6_RS09580	COG0583	DNA-binding transcription factor activity
IZ6_RS09590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IZ6_RS09605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IZ6_RS09610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IZ6_RS09615	COG1704	LemA family
IZ6_RS09620	COG0501	Belongs to the peptidase M48B family
IZ6_RS09635	COG0203	ribosomal protein L17
IZ6_RS09640	COG0202	RNA polymerase activity
IZ6_RS09645	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IZ6_RS09650	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IZ6_RS09655	COG0563	adenylate kinase activity
IZ6_RS09665	COG0200	Binds to the 23S rRNA
IZ6_RS09670	COG1841	ribosomal large subunit assembly
IZ6_RS09675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IZ6_RS09680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IZ6_RS09685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IZ6_RS09690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IZ6_RS09695	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IZ6_RS09700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IZ6_RS09705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IZ6_RS09710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IZ6_RS09715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IZ6_RS09725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IZ6_RS09730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IZ6_RS09735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IZ6_RS09740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IZ6_RS09745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IZ6_RS09750	COG0089	rRNA binding
IZ6_RS09755	COG0088	Forms part of the polypeptide exit tunnel
IZ6_RS09760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IZ6_RS09765	COG0051	transcription antitermination factor activity, RNA binding
IZ6_RS09770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IZ6_RS09775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IZ6_RS09780	COG0049	tRNA binding
IZ6_RS09785	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IZ6_RS09795	COG0667	Aldo Keto reductase
IZ6_RS09800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IZ6_RS09805	COG0085	RNA polymerase activity
IZ6_RS09810	COG0222	ribosome binding
IZ6_RS09815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IZ6_RS09820	COG0081	regulation of translation
IZ6_RS09835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IZ6_RS09850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IZ6_RS09865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IZ6_RS09875	COG0477	Major facilitator Superfamily
IZ6_RS09905	COG2079	MmgE PrpD family protein
IZ6_RS09930	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IZ6_RS09935	COG2086	electron transfer activity
IZ6_RS09945	COG1053	succinate dehydrogenase
IZ6_RS09955	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IZ6_RS10000	COG0861	Integral membrane protein TerC family
IZ6_RS10010	COG4566	intracellular signal transduction
IZ6_RS10015	COG0745	RESPONSE REGULATOR receiver
IZ6_RS10015	COG2205	protein histidine kinase activity
IZ6_RS10015	COG4191	Histidine kinase
IZ6_RS10020	COG1802	Transcriptional regulator
IZ6_RS10045	COG1238	metal cluster binding
IZ6_RS10075	COG1324	tolerance protein
IZ6_RS10080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IZ6_RS10120	COG0778	Nitroreductase
IZ6_RS10130	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IZ6_RS10135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IZ6_RS10145	COG0302	gtp cyclohydrolase
IZ6_RS10150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IZ6_RS10210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IZ6_RS10215	COG0513	Belongs to the DEAD box helicase family
IZ6_RS10220	COG0544	peptidyl-prolyl cis-trans isomerase activity
IZ6_RS10235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IZ6_RS10250	COG1058	Belongs to the CinA family
IZ6_RS10250	COG1546	Belongs to the CinA family
IZ6_RS10300	COG2900	Belongs to the SlyX family
IZ6_RS10305	COG1129	ABC transporter
IZ6_RS10305	COG0842	Transport permease protein
IZ6_RS10310	COG1131	(ABC) transporter
IZ6_RS10320	COG1309	transcriptional regulator
IZ6_RS10325	COG0745	RESPONSE REGULATOR receiver
IZ6_RS10330	COG2814	Major facilitator Superfamily
IZ6_RS10340	COG4251	negative regulation of phosphorylation
IZ6_RS10345	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IZ6_RS10355	COG1126	abc transporter atp-binding protein
IZ6_RS10360	COG0765	amino acid transport
IZ6_RS10365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IZ6_RS10370	COG1215	transferase activity, transferring glycosyl groups
IZ6_RS10375	COG1215	transferase activity, transferring glycosyl groups
IZ6_RS10380	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IZ6_RS10385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IZ6_RS10385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IZ6_RS10400	COG3768	UPF0283 membrane protein
IZ6_RS10415	COG3106	COG3106 Predicted ATPase
IZ6_RS10430	COG0633	Ferredoxin
IZ6_RS10435	COG0492	ferredoxin-NADP+ reductase activity
IZ6_RS10445	COG4948	Mandelate Racemase Muconate Lactonizing
IZ6_RS10455	COG0438	transferase activity, transferring glycosyl groups
IZ6_RS10465	COG0351	phosphomethylpyrimidine kinase
IZ6_RS10470	COG0697	spore germination
IZ6_RS10510	COG0850	regulation of cytokinetic process
IZ6_RS10520	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IZ6_RS10550	COG5001	Diguanylate cyclase
IZ6_RS10550	COG3300	MHYT domain
IZ6_RS10555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IZ6_RS10580	COG0384	phenazine biosynthesis protein PhzF
IZ6_RS10585	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IZ6_RS10590	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IZ6_RS10595	COG0440	acetolactate synthase activity
IZ6_RS10600	COG0028	Belongs to the TPP enzyme family
IZ6_RS10630	COG0560	Phosphoserine phosphatase
IZ6_RS10645	COG0330	HflC and HflK could
IZ6_RS10650	COG0330	HflC and HflK could
IZ6_RS10690	COG0114	fumarate hydratase activity
IZ6_RS10720	COG2264	protein methyltransferase activity
IZ6_RS10725	COG0006	proline dipeptidase activity
IZ6_RS10725	COG0006	proline dipeptidase activity
IZ6_RS10745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IZ6_RS10750	COG0497	DNA recombination
IZ6_RS10755	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IZ6_RS10765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IZ6_RS10770	COG0849	cell division
IZ6_RS10775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IZ6_RS10780	COG1181	Belongs to the D-alanine--D-alanine ligase family
IZ6_RS10785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IZ6_RS10790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IZ6_RS10795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IZ6_RS10805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IZ6_RS10810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IZ6_RS10820	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IZ6_RS10840	COG2001	Belongs to the MraZ family
IZ6_RS10860	COG0505	Belongs to the CarA family
IZ6_RS10870	COG0347	Belongs to the P(II) protein family
IZ6_RS10875	COG1309	transcriptional regulator
IZ6_RS10880	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS10895	COG3023	N-Acetylmuramoyl-L-alanine amidase
IZ6_RS10905	COG0697	spore germination
IZ6_RS10935	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS10940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IZ6_RS10945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IZ6_RS10960	COG0492	ferredoxin-NADP+ reductase activity
IZ6_RS10965	COG0583	DNA-binding transcription factor activity
IZ6_RS10970	COG0436	Aminotransferase
IZ6_RS10975	COG0625	glutathione transferase activity
IZ6_RS10980	COG0024	Methionine aminopeptidase
IZ6_RS10985	COG2003	Belongs to the UPF0758 family
IZ6_RS11000	COG1802	Transcriptional regulator
IZ6_RS11015	COG2084	Dehydrogenase
IZ6_RS11020	COG3932	Exopolysaccharide synthesis, ExoD
IZ6_RS11030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IZ6_RS11075	COG0785	Cytochrome C biogenesis protein
IZ6_RS11085	COG1132	(ABC) transporter
IZ6_RS11090	COG0488	(ABC) transporter
IZ6_RS11105	COG2226	methyltransferase
IZ6_RS11120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IZ6_RS11130	COG0183	Belongs to the thiolase family
IZ6_RS11135	COG0318	PFAM AMP-dependent synthetase and ligase
IZ6_RS11140	COG1268	BioY protein
IZ6_RS11145	COG1268	BioY protein
IZ6_RS11150	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IZ6_RS11155	COG1122	ATPase activity
IZ6_RS11165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IZ6_RS11190	COG0363	glucosamine-6-phosphate deaminase activity
IZ6_RS11195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IZ6_RS11200	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IZ6_RS11220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IZ6_RS11255	COG1012	belongs to the aldehyde dehydrogenase family
IZ6_RS11260	COG0174	glutamine synthetase
IZ6_RS11265	COG0531	amino acid
IZ6_RS11290	COG2132	Multicopper oxidase
IZ6_RS11325	COG0829	nickel cation binding
IZ6_RS11330	COG0831	urea catabolic process
IZ6_RS11330	COG0832	Belongs to the urease beta subunit family
IZ6_RS11340	COG0804	urea catabolic process
IZ6_RS11345	COG0783	Belongs to the Dps family
IZ6_RS11355	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IZ6_RS11360	COG0830	nickel cation binding
IZ6_RS11370	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IZ6_RS11405	COG2972	Histidine kinase
IZ6_RS11405	COG0840	transmembrane signaling receptor activity
IZ6_RS11415	COG2972	Histidine kinase
IZ6_RS11415	COG0840	transmembrane signaling receptor activity
IZ6_RS11420	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IZ6_RS11440	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IZ6_RS11445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IZ6_RS11450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IZ6_RS11470	COG0500	methyltransferase
IZ6_RS11495	COG3739	integral membrane protein
IZ6_RS11510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IZ6_RS11530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IZ6_RS11540	COG1278	Cold shock
IZ6_RS11560	COG3706	GGDEF domain
IZ6_RS11565	COG3237	CsbD-like
IZ6_RS11595	COG3300	MHYT domain
IZ6_RS11595	COG5001	Diguanylate cyclase
IZ6_RS11610	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IZ6_RS11620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IZ6_RS11630	COG0047	phosphoribosylformylglycinamidine synthase activity
IZ6_RS11635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IZ6_RS11640	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IZ6_RS11655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IZ6_RS11670	COG0538	isocitrate dehydrogenase activity
IZ6_RS11690	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IZ6_RS11705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IZ6_RS11710	COG1684	flagellar biosynthetic protein fliR
IZ6_RS11715	COG1987	bacterial-type flagellum assembly
IZ6_RS11720	COG1677	Flagellar hook-basal body complex protein FliE
IZ6_RS11725	COG1558	bacterial-type flagellum-dependent cell motility
IZ6_RS11730	COG1815	bacterial-type flagellum-dependent cell motility
IZ6_RS11740	COG1338	Plays a role in the flagellum-specific transport system
IZ6_RS11745	COG0546	phosphoglycolate phosphatase activity
IZ6_RS11780	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IZ6_RS11790	COG4786	Flagellar basal body rod
IZ6_RS11795	COG4786	Flagellar basal body rod
IZ6_RS11845	COG1706	bacterial-type flagellum-dependent cell motility
IZ6_RS11850	COG3951	Flagellar rod assembly protein muramidase FlgJ
IZ6_RS11865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IZ6_RS11870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IZ6_RS11875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IZ6_RS11880	COG5443	negative regulation of bacterial-type flagellum assembly
IZ6_RS11885	COG5442	Flagellar protein FlaF
IZ6_RS11900	COG1749	Flagellar hook protein flgE
IZ6_RS11905	COG2133	pyrroloquinoline quinone binding
IZ6_RS11925	COG4095	Psort location CytoplasmicMembrane, score
IZ6_RS11930	COG2252	PERMEase
IZ6_RS11935	COG5001	Diguanylate cyclase
IZ6_RS11940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IZ6_RS11945	COG0612	Peptidase, M16
IZ6_RS11975	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IZ6_RS11985	COG0109	protoheme IX farnesyltransferase activity
IZ6_RS11990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IZ6_RS11995	COG1565	acr, cog1565
IZ6_RS11995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IZ6_RS12005	COG0742	ribosomal rna small subunit methyltransferase
IZ6_RS12010	COG1187	pseudouridine synthase activity
IZ6_RS12015	COG0590	tRNA wobble adenosine to inosine editing
IZ6_RS12035	COG0166	Belongs to the GPI family
IZ6_RS12040	COG0612	Peptidase, M16
IZ6_RS12045	COG0612	Peptidase, M16
IZ6_RS12055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IZ6_RS12060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IZ6_RS12065	COG0196	riboflavin kinase activity
IZ6_RS12070	COG0745	RESPONSE REGULATOR receiver
IZ6_RS12085	COG1663	tetraacyldisaccharide 4'-kinase activity
IZ6_RS12090	COG1519	Transferase
IZ6_RS12100	COG0483	inositol monophosphate 1-phosphatase activity
IZ6_RS12110	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IZ6_RS12125	COG1376	ErfK ybiS ycfS ynhG family protein
IZ6_RS12140	COG0583	DNA-binding transcription factor activity
IZ6_RS12155	COG0151	Belongs to the GarS family
IZ6_RS12160	COG1570	exodeoxyribonuclease VII activity
IZ6_RS12190	COG0671	phosphoesterase, PA-phosphatase related
IZ6_RS12200	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IZ6_RS12205	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IZ6_RS12210	COG0412	Dienelactone hydrolase
IZ6_RS12215	COG5487	UPF0391 membrane protein
IZ6_RS12225	COG1028	Short-chain dehydrogenase reductase Sdr
IZ6_RS12230	COG0459	protein refolding
IZ6_RS12245	COG1132	(ABC) transporter
IZ6_RS12255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IZ6_RS12265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IZ6_RS12290	COG0352	thiamine-phosphate diphosphorylase activity
IZ6_RS12365	COG3750	Belongs to the UPF0335 family
IZ6_RS12385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IZ6_RS12385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IZ6_RS12475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IZ6_RS12490	COG1702	phosphate starvation-inducible protein PhoH
IZ6_RS12840	COG1690	Belongs to the RtcB family
IZ6_RS12930	COG2205	protein histidine kinase activity
IZ6_RS12945	COG1840	ABC-type Fe3 transport system, periplasmic component
IZ6_RS12950	COG1178	ABC-type Fe3 transport system permease component
IZ6_RS12955	COG1177	transmembrane transport
IZ6_RS12960	COG1176	ABC-type spermidine putrescine transport system, permease component I
IZ6_RS12965	COG3842	ATPase activity
IZ6_RS12975	COG0174	glutamine synthetase
IZ6_RS12980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IZ6_RS12990	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IZ6_RS12995	COG4208	sulfate ABC transporter
IZ6_RS13000	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IZ6_RS13005	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IZ6_RS13010	COG0175	sulfate reduction
IZ6_RS13015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IZ6_RS13015	COG1648	precorrin-2 dehydrogenase activity
IZ6_RS13025	COG1132	(ABC) transporter
IZ6_RS13030	COG3383	formate dehydrogenase (NAD+) activity
IZ6_RS13050	COG1126	abc transporter atp-binding protein
IZ6_RS13065	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IZ6_RS13070	COG0640	Transcriptional regulator
IZ6_RS13085	COG0303	'Molybdopterin
IZ6_RS13105	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IZ6_RS13110	COG0424	maF-like protein
IZ6_RS13120	COG5328	Belongs to the UPF0262 family
IZ6_RS13125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IZ6_RS13145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IZ6_RS13160	COG0156	8-amino-7-oxononanoate synthase activity
IZ6_RS13165	COG1970	mechanosensitive ion channel activity
IZ6_RS13175	COG2198	Histidine kinase
IZ6_RS13175	COG0784	Response regulator, receiver
IZ6_RS13175	COG2205	protein histidine kinase activity
IZ6_RS13185	COG0432	Pfam Uncharacterised protein family UPF0047
IZ6_RS13230	COG1999	signal sequence binding
IZ6_RS13240	COG0463	Glycosyl transferase, family 2
IZ6_RS13245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IZ6_RS13250	COG4597	amino acid ABC transporter
IZ6_RS13255	COG0765	amino acid transport
IZ6_RS13260	COG1126	abc transporter atp-binding protein
IZ6_RS13315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IZ6_RS13350	COG3206	protein involved in exopolysaccharide biosynthesis
IZ6_RS13350	COG0489	protein tyrosine kinase activity
IZ6_RS13360	COG0438	transferase activity, transferring glycosyl groups
IZ6_RS13380	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IZ6_RS13390	COG5039	Polysaccharide pyruvyl transferase
IZ6_RS13400	COG2244	polysaccharide biosynthetic process
IZ6_RS13410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IZ6_RS13420	COG0579	oxidoreductase
IZ6_RS13425	COG0318	PFAM AMP-dependent synthetase and ligase
IZ6_RS13445	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IZ6_RS13450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IZ6_RS13485	COG0717	Belongs to the dCTP deaminase family
IZ6_RS13495	COG2967	ApaG domain
IZ6_RS13500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IZ6_RS13505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IZ6_RS13510	COG1252	NADH dehydrogenase
IZ6_RS13520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IZ6_RS13525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IZ6_RS13540	COG0745	RESPONSE REGULATOR receiver
IZ6_RS13545	COG0704	Plays a role in the regulation of phosphate uptake
IZ6_RS13550	COG5002	protein histidine kinase activity
IZ6_RS13555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IZ6_RS13560	COG3568	Endonuclease Exonuclease Phosphatase
IZ6_RS13565	COG3437	response regulator, receiver
IZ6_RS13565	COG0784	Response regulator, receiver
IZ6_RS13580	COG4191	Histidine kinase
IZ6_RS13585	COG0747	negative chemotaxis
IZ6_RS13590	COG1764	response to oxidative stress
IZ6_RS13615	COG0058	SHG alpha-glucan phosphorylase activity
IZ6_RS13620	COG0142	geranyltranstransferase activity
IZ6_RS13630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IZ6_RS13640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IZ6_RS13655	COG1657	PFAM Prenyltransferase squalene oxidase
IZ6_RS13660	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IZ6_RS13665	COG1562	ergosterol biosynthetic process
IZ6_RS13670	COG1562	ergosterol biosynthetic process
IZ6_RS13680	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IZ6_RS13695	COG5001	Diguanylate cyclase
IZ6_RS13695	COG3300	MHYT domain
IZ6_RS13700	COG0697	spore germination
IZ6_RS13710	COG4191	Histidine kinase
IZ6_RS13715	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IZ6_RS13720	COG0594	ribonuclease P activity
IZ6_RS13725	COG0706	membrane insertase activity
IZ6_RS13735	COG2171	N-acyltransferase activity
IZ6_RS13765	COG0101	tRNA pseudouridine synthase activity
IZ6_RS13770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IZ6_RS13775	COG0242	peptide deformylase activity
IZ6_RS13785	COG2211	Major facilitator Superfamily
IZ6_RS13795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IZ6_RS13800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IZ6_RS13805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IZ6_RS13830	COG0077	Prephenate dehydratase
IZ6_RS13835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IZ6_RS13840	COG3474	cytochrome
IZ6_RS13845	COG4166	transmembrane transport
IZ6_RS13850	COG4166	transmembrane transport
IZ6_RS13855	COG4174	ABC transporter (Permease)
IZ6_RS13860	COG4239	(ABC) transporter, permease
IZ6_RS13865	COG4172	Belongs to the ABC transporter superfamily
IZ6_RS13875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IZ6_RS13910	COG4964	Belongs to the GSP D family
IZ6_RS13965	COG1803	Methylglyoxal synthase
IZ6_RS13970	COG1643	Atp-dependent helicase
IZ6_RS14015	COG0175	sulfate reduction
IZ6_RS14020	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IZ6_RS14035	COG1640	4-alpha-glucanotransferase
IZ6_RS14055	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IZ6_RS14075	COG1968	undecaprenyl-diphosphatase activity
IZ6_RS14090	COG0513	Belongs to the DEAD box helicase family
IZ6_RS14100	COG0339	signal peptide processing
IZ6_RS14105	COG0842	Transport permease protein
IZ6_RS14110	COG1131	(ABC) transporter
IZ6_RS14135	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IZ6_RS14140	COG1137	ATPase activity
IZ6_RS14145	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IZ6_RS14150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IZ6_RS14155	COG2197	response regulator
IZ6_RS14160	COG1136	(ABC) transporter
IZ6_RS14160	COG0577	efflux transmembrane transporter activity
IZ6_RS14165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IZ6_RS14175	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IZ6_RS14190	COG1671	Belongs to the UPF0178 family
IZ6_RS14205	COG1763	Mo-molybdopterin cofactor biosynthetic process
IZ6_RS14210	COG0746	molybdenum cofactor guanylyltransferase activity
IZ6_RS14220	COG1984	allophanate hydrolase subunit 2
IZ6_RS14225	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IZ6_RS14235	COG0741	lytic transglycosylase activity
IZ6_RS14235	COG1196	nuclear chromosome segregation
IZ6_RS14235	COG0739	heme binding
IZ6_RS14250	COG0745	RESPONSE REGULATOR receiver
IZ6_RS14255	COG0642	Histidine kinase
IZ6_RS14270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IZ6_RS14275	COG4651	solute:proton antiporter activity
IZ6_RS14275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IZ6_RS14285	COG1064	alcohol dehydrogenase
IZ6_RS14300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IZ6_RS14305	COG2205	protein histidine kinase activity
IZ6_RS14310	COG3178	'Phosphotransferase
IZ6_RS14315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IZ6_RS14320	COG2887	Belongs to the helicase family. UvrD subfamily
IZ6_RS14325	COG1074	ATP-dependent DNA helicase activity
IZ6_RS14340	COG0285	dihydrofolate synthase activity
IZ6_RS14345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IZ6_RS14355	COG0133	tryptophan synthase activity
IZ6_RS14360	COG0135	phosphoribosylanthranilate isomerase activity
IZ6_RS14370	COG0776	regulation of translation
IZ6_RS14375	COG0616	signal peptide processing
IZ6_RS14380	COG0539	negative regulation of cytoplasmic translation
IZ6_RS14385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IZ6_RS14390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IZ6_RS14405	COG0463	Glycosyl transferase, family 2
IZ6_RS14415	COG0071	Belongs to the small heat shock protein (HSP20) family
IZ6_RS14425	COG1420	regulation of RNA biosynthetic process
IZ6_RS14430	COG2358	TRAP transporter, solute receptor (TAXI family
IZ6_RS14440	COG0765	amino acid transport
IZ6_RS14445	COG0765	amino acid transport
IZ6_RS14450	COG1126	abc transporter atp-binding protein
IZ6_RS14465	COG4208	sulfate ABC transporter
IZ6_RS14470	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IZ6_RS14475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IZ6_RS14480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IZ6_RS14495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IZ6_RS14500	COG0792	nuclease activity
IZ6_RS14505	COG0189	ligase activity
IZ6_RS14570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IZ6_RS14590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IZ6_RS14595	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IZ6_RS14600	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IZ6_RS14620	COG0481	GTPase activity
IZ6_RS14630	COG2326	polyphosphate kinase activity
IZ6_RS14635	COG1376	ErfK ybiS ycfS ynhG family protein
IZ6_RS14640	COG5001	Diguanylate cyclase
IZ6_RS14650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IZ6_RS14655	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
IZ6_RS14660	COG0438	transferase activity, transferring glycosyl groups
IZ6_RS14670	COG3685	Protein conserved in bacteria
IZ6_RS14685	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IZ6_RS14690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IZ6_RS14725	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IZ6_RS14730	COG1012	belongs to the aldehyde dehydrogenase family
IZ6_RS14750	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IZ6_RS14755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IZ6_RS14760	COG4558	Periplasmic binding protein
IZ6_RS14770	COG4771	TonB-dependent receptor
IZ6_RS14770	COG1629	transport
IZ6_RS14795	COG1216	Glycosyl transferase, family 2
IZ6_RS14800	COG1442	glycosyl transferase family 8
IZ6_RS14805	COG1216	Glycosyl transferase, family 2
IZ6_RS14815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IZ6_RS14830	COG0395	ABC-type sugar transport system, permease component
IZ6_RS14840	COG3842	ATPase activity
IZ6_RS14845	COG3842	ATPase activity
IZ6_RS14860	COG1132	(ABC) transporter
IZ6_RS14870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IZ6_RS14885	COG0395	ABC-type sugar transport system, permease component
IZ6_RS14890	COG1176	ABC-type spermidine putrescine transport system, permease component I
IZ6_RS14900	COG3842	ATPase activity
IZ6_RS14905	COG2186	Transcriptional regulator
IZ6_RS14920	COG3180	Ammonia monooxygenase
IZ6_RS14930	COG3622	Belongs to the hyi family
IZ6_RS14940	COG2205	protein histidine kinase activity
IZ6_RS14945	COG2201	protein-glutamate methylesterase activity
IZ6_RS14955	COG0840	transmembrane signaling receptor activity
IZ6_RS14970	COG0835	chemotaxis
IZ6_RS14975	COG0425	Belongs to the sulfur carrier protein TusA family
IZ6_RS14980	COG0776	regulation of translation
IZ6_RS14985	COG4191	Histidine kinase
IZ6_RS14985	COG0784	Response regulator, receiver
IZ6_RS14990	COG3850	Histidine kinase
IZ6_RS14990	COG4999	Histidine kinase
IZ6_RS14990	COG3437	response regulator, receiver
IZ6_RS14990	COG2205	protein histidine kinase activity
IZ6_RS15005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IZ6_RS15020	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IZ6_RS15025	COG0277	FAD linked oxidase domain protein
IZ6_RS15035	COG0247	lactate metabolic process
IZ6_RS15045	COG1304	FMN binding
IZ6_RS15050	COG2096	Adenosyltransferase
IZ6_RS15055	COG1120	ATPase activity
IZ6_RS15060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IZ6_RS15070	COG4206	TonB-dependent receptor
IZ6_RS15085	COG0243	molybdopterin cofactor binding
IZ6_RS15090	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IZ6_RS15095	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IZ6_RS15100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IZ6_RS15105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IZ6_RS15105	COG1017	nitric oxide dioxygenase activity
IZ6_RS15110	COG1116	anion transmembrane transporter activity
IZ6_RS15115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IZ6_RS15120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IZ6_RS15130	COG3707	response regulator
IZ6_RS15145	COG2217	Heavy metal translocating P-type atpase
IZ6_RS15160	COG2010	Cytochrome c
IZ6_RS15175	COG3278	Belongs to the heme-copper respiratory oxidase family
IZ6_RS15180	COG4566	intracellular signal transduction
IZ6_RS15185	COG4191	Histidine kinase
IZ6_RS15220	COG0069	glutamate synthase activity
IZ6_RS15225	COG2218	PFAM glutamate synthase alpha subunit domain protein
IZ6_RS15230	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IZ6_RS15240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IZ6_RS15250	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IZ6_RS15250	COG0446	pyridine nucleotide-disulphide oxidoreductase
IZ6_RS15270	COG1091	dTDP-4-dehydrorhamnose reductase activity
IZ6_RS15275	COG1088	dTDP-glucose 4,6-dehydratase activity
IZ6_RS15295	COG1335	isochorismatase
IZ6_RS15300	COG3845	ABC transporter
IZ6_RS15305	COG1335	isochorismatase
IZ6_RS15310	COG1079	Belongs to the binding-protein-dependent transport system permease family
IZ6_RS15325	COG0583	DNA-binding transcription factor activity
IZ6_RS15330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IZ6_RS15350	COG1116	anion transmembrane transporter activity
IZ6_RS15355	COG0454	-acetyltransferase
IZ6_RS15365	COG0439	Biotin carboxylase
IZ6_RS15385	COG1201	RNA secondary structure unwinding
IZ6_RS15400	COG1793	dna ligase
IZ6_RS15410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IZ6_RS15425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IZ6_RS15435	COG0561	phosphatase activity
IZ6_RS15440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IZ6_RS15450	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IZ6_RS15455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IZ6_RS15470	COG1733	regulation of RNA biosynthetic process
IZ6_RS15480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IZ6_RS15480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IZ6_RS15495	COG0450	alkyl hydroperoxide reductase
IZ6_RS15500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IZ6_RS15505	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IZ6_RS15515	COG5002	protein histidine kinase activity
IZ6_RS15535	COG0745	RESPONSE REGULATOR receiver
IZ6_RS15540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IZ6_RS15555	COG1215	transferase activity, transferring glycosyl groups
IZ6_RS15615	COG2847	Copper chaperone PCu(A)C
IZ6_RS15625	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IZ6_RS15650	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IZ6_RS15665	COG0443	Heat shock 70 kDa protein
IZ6_RS15670	COG0484	heat shock protein binding
IZ6_RS15675	COG3963	phosphatidate phosphatase activity
IZ6_RS15685	COG0284	orotidine-5'-phosphate decarboxylase activity
IZ6_RS15695	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IZ6_RS15700	COG0588	phosphoglycerate mutase activity
IZ6_RS15735	COG0137	argininosuccinate synthase activity
IZ6_RS15745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IZ6_RS15760	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IZ6_RS15780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IZ6_RS15785	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IZ6_RS15790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IZ6_RS15795	COG0072	phenylalanine-tRNA ligase activity
IZ6_RS15795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IZ6_RS15820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IZ6_RS15840	COG1217	gtp-binding protein TYPA
IZ6_RS15855	COG1959	2 iron, 2 sulfur cluster binding
IZ6_RS15860	COG0756	dUTP diphosphatase activity
IZ6_RS15865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IZ6_RS15870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IZ6_RS15875	COG2226	methyltransferase
IZ6_RS15880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IZ6_RS15885	COG0268	Binds directly to 16S ribosomal RNA
IZ6_RS15905	COG4191	Histidine kinase
IZ6_RS15915	COG5002	protein histidine kinase activity
IZ6_RS15945	COG0671	phosphoesterase, PA-phosphatase related
IZ6_RS15960	COG0318	PFAM AMP-dependent synthetase and ligase
IZ6_RS15965	COG1376	ErfK ybiS ycfS ynhG family protein
IZ6_RS15985	COG1278	Cold shock
IZ6_RS16000	COG1686	Belongs to the peptidase S11 family