locus-tag	class	description
BW730_RS00010	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BW730_RS00025	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BW730_RS00035	COG1082	Xylose isomerase domain protein TIM barrel
BW730_RS00040	COG0506	proline dehydrogenase activity
BW730_RS00055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BW730_RS00070	COG1648	precorrin-2 dehydrogenase activity
BW730_RS00070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BW730_RS00075	COG0406	alpha-ribazole phosphatase activity
BW730_RS00080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW730_RS00085	COG0785	Cytochrome C biogenesis protein
BW730_RS00090	COG1333	cytochrome c biogenesis protein
BW730_RS00095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BW730_RS00105	COG0300	oxidoreductase activity
BW730_RS00125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BW730_RS00145	COG0406	alpha-ribazole phosphatase activity
BW730_RS00145	COG0494	nUDIX hydrolase
BW730_RS00150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BW730_RS00155	COG0745	RESPONSE REGULATOR receiver
BW730_RS00165	COG1490	D-aminoacyl-tRNA deacylase activity
BW730_RS00170	COG3485	protocatechuate 3,4-dioxygenase
BW730_RS00175	COG0354	folic acid binding
BW730_RS00190	COG1454	alcohol dehydrogenase
BW730_RS00210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BW730_RS00250	COG1609	Transcriptional regulator
BW730_RS00260	COG1175	transmembrane transport
BW730_RS00280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BW730_RS00280	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BW730_RS00280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW730_RS00285	COG1461	Dihydroxyacetone kinase
BW730_RS00290	COG2376	Dihydroxyacetone kinase
BW730_RS00295	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BW730_RS00305	COG2318	DinB family
BW730_RS00365	COG1028	Short-chain dehydrogenase reductase Sdr
BW730_RS00390	COG1846	Transcriptional regulator
BW730_RS00400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BW730_RS00415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BW730_RS00440	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BW730_RS00450	COG0765	amino acid transport
BW730_RS00455	COG0765	amino acid transport
BW730_RS00460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW730_RS00465	COG1126	abc transporter atp-binding protein
BW730_RS00495	COG1648	precorrin-2 dehydrogenase activity
BW730_RS00495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BW730_RS00505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BW730_RS00510	COG1609	Transcriptional regulator
BW730_RS00515	COG1609	Transcriptional regulator
BW730_RS00525	COG1129	ABC transporter
BW730_RS00530	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS00535	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS00565	COG2094	Belongs to the DNA glycosylase MPG family
BW730_RS00575	COG0436	Aminotransferase
BW730_RS00580	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BW730_RS00585	COG0047	phosphoribosylformylglycinamidine synthase activity
BW730_RS00615	COG0673	inositol 2-dehydrogenase activity
BW730_RS00645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BW730_RS00655	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BW730_RS00660	COG1027	Aspartate ammonia-lyase
BW730_RS00665	COG2234	aminopeptidase activity
BW730_RS00685	COG1609	Transcriptional regulator
BW730_RS00690	COG2182	Extracellular solute-binding protein
BW730_RS00700	COG3833	ABC-type maltose transport systems, permease component
BW730_RS00705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BW730_RS00760	COG3420	alginic acid biosynthetic process
BW730_RS00810	COG1140	nitrate reductase beta subunit
BW730_RS00815	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BW730_RS00835	COG0314	molybdopterin synthase activity
BW730_RS00840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BW730_RS00850	COG0315	cyclic pyranopterin monophosphate synthase activity
BW730_RS00855	COG2378	regulation of single-species biofilm formation
BW730_RS00885	COG0521	Mo-molybdopterin cofactor biosynthetic process
BW730_RS00885	COG0315	cyclic pyranopterin monophosphate synthase activity
BW730_RS00920	COG0577	efflux transmembrane transporter activity
BW730_RS00920	COG1136	(ABC) transporter
BW730_RS00940	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BW730_RS00955	COG0395	ABC-type sugar transport system, permease component
BW730_RS00960	COG0442	prolyl-tRNA aminoacylation
BW730_RS00990	COG5398	heme oxygenase
BW730_RS01000	COG2838	Isocitrate dehydrogenase
BW730_RS01040	COG1333	cytochrome c biogenesis protein
BW730_RS01045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BW730_RS01120	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BW730_RS01130	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BW730_RS01145	COG0667	Aldo Keto reductase
BW730_RS01150	COG1794	racemase activity, acting on amino acids and derivatives
BW730_RS01175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BW730_RS01200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BW730_RS01205	COG1461	Dihydroxyacetone kinase
BW730_RS01225	COG4948	Mandelate Racemase Muconate Lactonizing
BW730_RS01230	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BW730_RS01240	COG2226	methyltransferase
BW730_RS01245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BW730_RS01255	COG1169	isochorismate synthase
BW730_RS01260	COG0644	oxidoreductase
BW730_RS01270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW730_RS01275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW730_RS01280	COG0649	NAD binding
BW730_RS01290	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BW730_RS01300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BW730_RS01305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW730_RS01330	COG1007	ATP synthesis coupled electron transport
BW730_RS01345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BW730_RS01350	COG2197	response regulator
BW730_RS01355	COG2909	trisaccharide binding
BW730_RS01365	COG0471	metal ion transport
BW730_RS01365	COG0490	domain, Protein
BW730_RS01390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BW730_RS01390	COG0674	pyruvate-flavodoxin oxidoreductase activity
BW730_RS01395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BW730_RS01405	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW730_RS01415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW730_RS01435	COG1666	GTP binding
BW730_RS01445	COG0813	purine-nucleoside phosphorylase activity
BW730_RS01465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BW730_RS01480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BW730_RS01490	COG1473	amidohydrolase
BW730_RS01495	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BW730_RS01510	COG1672	PFAM Archaeal ATPase
BW730_RS01510	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
BW730_RS01520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BW730_RS01535	COG0395	ABC-type sugar transport system, permease component
BW730_RS01580	COG1739	Uncharacterized protein family UPF0029
BW730_RS01600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW730_RS01610	COG2205	protein histidine kinase activity
BW730_RS01615	COG0745	RESPONSE REGULATOR receiver
BW730_RS01650	COG1064	alcohol dehydrogenase
BW730_RS01765	COG1321	iron dependent repressor
BW730_RS01790	COG2132	Multicopper oxidase
BW730_RS01830	COG0785	Cytochrome C biogenesis protein
BW730_RS01850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BW730_RS01850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BW730_RS01890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BW730_RS01985	COG1196	nuclear chromosome segregation
BW730_RS01985	COG0741	lytic transglycosylase activity
BW730_RS01985	COG0739	heme binding
BW730_RS02040	COG0629	single-stranded DNA binding
BW730_RS02120	COG1595	DNA-templated transcription, initiation
BW730_RS02125	COG0247	lactate metabolic process
BW730_RS02125	COG0277	FAD linked oxidase domain protein
BW730_RS02145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BW730_RS02190	COG0395	ABC-type sugar transport system, permease component
BW730_RS02195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BW730_RS02200	COG0540	Belongs to the ATCase OTCase family
BW730_RS02205	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BW730_RS02285	COG1175	transmembrane transport
BW730_RS02290	COG0395	ABC-type sugar transport system, permease component
BW730_RS02295	COG1472	Belongs to the glycosyl hydrolase 3 family
BW730_RS02310	COG3654	unkown
BW730_RS02330	COG0544	peptidyl-prolyl cis-trans isomerase activity
BW730_RS02335	COG0628	permease
BW730_RS02340	COG0740	serine-type endopeptidase activity
BW730_RS02345	COG0740	serine-type endopeptidase activity
BW730_RS02355	COG4946	Tricorn protease homolog
BW730_RS02355	COG0793	Belongs to the peptidase S41A family
BW730_RS02375	COG1175	transmembrane transport
BW730_RS02385	COG1472	Belongs to the glycosyl hydrolase 3 family
BW730_RS02390	COG3250	beta-galactosidase activity
BW730_RS02395	COG0395	ABC-type sugar transport system, permease component
BW730_RS02400	COG1175	transmembrane transport
BW730_RS02415	COG0525	valine-tRNA ligase activity
BW730_RS02435	COG0285	dihydrofolate synthase activity
BW730_RS02445	COG0105	UTP biosynthetic process
BW730_RS02470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BW730_RS02475	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW730_RS02475	COG0596	Alpha beta hydrolase
BW730_RS02480	COG4868	Belongs to the UPF0371 family
BW730_RS02485	COG2807	transmembrane transport
BW730_RS02500	COG3250	beta-galactosidase activity
BW730_RS02505	COG0395	ABC-type sugar transport system, permease component
BW730_RS02510	COG1175	transmembrane transport
BW730_RS02525	COG1940	carbohydrate kinase activity
BW730_RS02535	COG1530	ribonuclease E activity
BW730_RS02540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BW730_RS02545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BW730_RS02555	COG2197	response regulator
BW730_RS02560	COG4585	Histidine kinase
BW730_RS02570	COG1131	(ABC) transporter
BW730_RS02585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BW730_RS02605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BW730_RS02610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BW730_RS02655	COG0616	signal peptide processing
BW730_RS02665	COG0228	four-way junction DNA binding
BW730_RS02670	COG1837	Belongs to the UPF0109 family
BW730_RS02675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BW730_RS02680	COG0336	Belongs to the RNA methyltransferase TrmD family
BW730_RS02690	COG1053	succinate dehydrogenase
BW730_RS02695	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BW730_RS02700	COG0335	large ribosomal subunit rRNA binding
BW730_RS02715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BW730_RS02725	COG0792	nuclease activity
BW730_RS02750	COG0577	efflux transmembrane transporter activity
BW730_RS02755	COG1136	(ABC) transporter
BW730_RS02755	COG0577	efflux transmembrane transporter activity
BW730_RS02765	COG0577	efflux transmembrane transporter activity
BW730_RS02765	COG1136	(ABC) transporter
BW730_RS02785	COG2226	methyltransferase
BW730_RS02830	COG0395	ABC-type sugar transport system, permease component
BW730_RS02835	COG1175	transmembrane transport
BW730_RS02845	COG1609	Transcriptional regulator
BW730_RS02860	COG1129	ABC transporter
BW730_RS02865	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS02870	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS02905	COG0667	Aldo Keto reductase
BW730_RS02910	COG1968	undecaprenyl-diphosphatase activity
BW730_RS02930	COG0215	cysteine-tRNA ligase activity
BW730_RS02935	COG0140	phosphoribosyl-ATP diphosphatase activity
BW730_RS02940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BW730_RS02965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BW730_RS02970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BW730_RS02975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BW730_RS02985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BW730_RS02990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW730_RS02990	COG0072	phenylalanine-tRNA ligase activity
BW730_RS02995	COG2827	Endonuclease containing a URI domain
BW730_RS03050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BW730_RS03055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BW730_RS03060	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BW730_RS03075	COG0165	Argininosuccinate lyase
BW730_RS03080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BW730_RS03130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BW730_RS03155	COG4552	Acetyltransferase involved in intracellular survival and related
BW730_RS03175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BW730_RS03195	COG2378	regulation of single-species biofilm formation
BW730_RS03210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BW730_RS03215	COG0805	protein transport
BW730_RS03230	COG4581	dead DEAH box helicase
BW730_RS03235	COG0107	imidazoleglycerol-phosphate synthase activity
BW730_RS03240	COG0537	adenosine 5'-monophosphoramidase activity
BW730_RS03255	COG0440	acetolactate synthase activity
BW730_RS03270	COG1063	alcohol dehydrogenase
BW730_RS03275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BW730_RS03280	COG1349	DNA-binding transcription factor activity
BW730_RS03300	COG1595	DNA-templated transcription, initiation
BW730_RS03305	COG2239	Acts as a magnesium transporter
BW730_RS03315	COG0473	3-isopropylmalate dehydrogenase activity
BW730_RS03320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BW730_RS03330	COG1266	CAAX protease self-immunity
BW730_RS03345	COG2375	cellular response to nickel ion
BW730_RS03350	COG1414	Transcriptional regulator
BW730_RS03355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BW730_RS03360	COG0066	3-isopropylmalate dehydratase activity
BW730_RS03375	COG1505	serine-type exopeptidase activity
BW730_RS03385	COG0740	serine-type endopeptidase activity
BW730_RS03390	COG0740	serine-type endopeptidase activity
BW730_RS03405	COG1181	Belongs to the D-alanine--D-alanine ligase family
BW730_RS03420	COG1674	ftsk spoiiie
BW730_RS03425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW730_RS03435	COG1058	Belongs to the CinA family
BW730_RS03435	COG1546	Belongs to the CinA family
BW730_RS03440	COG1396	sequence-specific DNA binding
BW730_RS03445	COG1349	DNA-binding transcription factor activity
BW730_RS03460	COG2137	regulation of response to DNA damage stimulus
BW730_RS03465	COG1418	mRNA catabolic process
BW730_RS03470	COG2017	converts alpha-aldose to the beta-anomer
BW730_RS03475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW730_RS03485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BW730_RS03490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BW730_RS03495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BW730_RS03505	COG0366	Alpha amylase catalytic
BW730_RS03515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BW730_RS03520	COG2226	methyltransferase
BW730_RS03540	COG1028	Short-chain dehydrogenase reductase Sdr
BW730_RS03550	COG1063	alcohol dehydrogenase
BW730_RS03555	COG0656	L-ascorbic acid biosynthetic process
BW730_RS03565	COG1119	ATPase activity
BW730_RS03585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BW730_RS03585	COG0512	Glutamine amidotransferase of anthranilate synthase
BW730_RS03595	COG0242	peptide deformylase activity
BW730_RS03600	COG4974	Belongs to the 'phage' integrase family
BW730_RS03605	COG0739	heme binding
BW730_RS03605	COG0741	lytic transglycosylase activity
BW730_RS03605	COG1196	nuclear chromosome segregation
BW730_RS03610	COG0052	Belongs to the universal ribosomal protein uS2 family
BW730_RS03615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BW730_RS03620	COG0528	UMP kinase activity
BW730_RS03625	COG0233	cytoplasmic translational termination
BW730_RS03630	COG0575	Belongs to the CDS family
BW730_RS03635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BW730_RS03640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BW730_RS03655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BW730_RS03660	COG0750	zinc metalloprotease
BW730_RS03665	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BW730_RS03680	COG0442	prolyl-tRNA aminoacylation
BW730_RS03685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW730_RS03690	COG0800	Aldolase
BW730_RS03700	COG2964	Protein conserved in bacteria
BW730_RS03715	COG1653	transport
BW730_RS03720	COG1175	transmembrane transport
BW730_RS03740	COG0779	Required for maturation of 30S ribosomal subunits
BW730_RS03765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BW730_RS03770	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BW730_RS03775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BW730_RS03790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BW730_RS03795	COG1879	ABC-type sugar transport system periplasmic component
BW730_RS03805	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS03810	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS03820	COG1185	polyribonucleotide nucleotidyltransferase activity
BW730_RS03825	COG2197	response regulator
BW730_RS03840	COG1879	ABC-type sugar transport system periplasmic component
BW730_RS03845	COG1129	ABC transporter
BW730_RS03850	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS03855	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BW730_RS03890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BW730_RS03895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BW730_RS03900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BW730_RS03905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BW730_RS03910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BW730_RS03920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BW730_RS03925	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BW730_RS03935	COG0406	alpha-ribazole phosphatase activity
BW730_RS03945	COG3253	May function as heme-dependent peroxidase
BW730_RS03945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BW730_RS03950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BW730_RS03955	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BW730_RS03970	COG0181	hydroxymethylbilane synthase activity
BW730_RS03980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BW730_RS03985	COG0181	hydroxymethylbilane synthase activity
BW730_RS04020	COG0601	transmembrane transport
BW730_RS04030	COG0747	negative chemotaxis
BW730_RS04035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BW730_RS04045	COG0444	Belongs to the ABC transporter superfamily
BW730_RS04060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW730_RS04065	COG0446	pyridine nucleotide-disulphide oxidoreductase
BW730_RS04070	COG1937	Protein conserved in bacteria
BW730_RS04090	COG2070	2-Nitropropane dioxygenase
BW730_RS04100	COG0659	secondary active sulfate transmembrane transporter activity
BW730_RS04115	COG1733	regulation of RNA biosynthetic process
BW730_RS04120	COG2910	NAD(P)H-binding
BW730_RS04135	COG0025	NhaP-type Na H and K H
BW730_RS04140	COG2855	membrane
BW730_RS04190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW730_RS04195	COG0495	leucyl-tRNA aminoacylation
BW730_RS04210	COG5290	Psort location Cytoplasmic, score
BW730_RS04220	COG1596	polysaccharide export
BW730_RS04220	COG1555	photosystem II stabilization
BW730_RS04225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW730_RS04260	COG0673	inositol 2-dehydrogenase activity
BW730_RS04270	COG1595	DNA-templated transcription, initiation
BW730_RS04285	COG0268	Binds directly to 16S ribosomal RNA
BW730_RS04290	COG0481	GTPase activity
BW730_RS04295	COG1643	Atp-dependent helicase
BW730_RS04300	COG0395	ABC-type sugar transport system, permease component
BW730_RS04305	COG1175	transmembrane transport
BW730_RS04325	COG1725	Transcriptional regulator
BW730_RS04330	COG1131	(ABC) transporter
BW730_RS04350	COG1609	Transcriptional regulator
BW730_RS04375	COG0395	ABC-type sugar transport system, permease component
BW730_RS04380	COG3507	Belongs to the glycosyl hydrolase 43 family
BW730_RS04390	COG1609	Transcriptional regulator
BW730_RS04400	COG2160	L-arabinose isomerase activity
BW730_RS04415	COG3534	alpha-L-arabinofuranosidase
BW730_RS04425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW730_RS04430	COG1420	regulation of RNA biosynthetic process
BW730_RS04435	COG0484	heat shock protein binding
BW730_RS04445	COG0343	queuine tRNA-ribosyltransferase activity
BW730_RS04465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BW730_RS04480	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BW730_RS04490	COG1175	transmembrane transport
BW730_RS04495	COG0395	ABC-type sugar transport system, permease component
BW730_RS04500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BW730_RS04505	COG1408	metallophosphoesterase
BW730_RS04520	COG2826	transposase and inactivated derivatives, IS30 family
BW730_RS04525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BW730_RS04530	COG1381	Involved in DNA repair and RecF pathway recombination
BW730_RS04540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BW730_RS04545	COG1121	(ABC) transporter
BW730_RS04550	COG0803	Belongs to the bacterial solute-binding protein 9 family
BW730_RS04575	COG0277	FAD linked oxidase domain protein
BW730_RS04615	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BW730_RS04635	COG3655	Transcriptional regulator
BW730_RS04640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BW730_RS04670	COG0714	Associated with various cellular activities
BW730_RS04680	COG2304	oxidoreductase activity
BW730_RS04685	COG2304	oxidoreductase activity
BW730_RS04690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BW730_RS04710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BW730_RS04715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BW730_RS04720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BW730_RS04740	COG1115	amino acid carrier protein
BW730_RS04750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BW730_RS04750	COG1648	precorrin-2 dehydrogenase activity
BW730_RS04755	COG1796	DNA polymerase
BW730_RS04755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BW730_RS04760	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BW730_RS04780	COG3848	Pyruvate phosphate dikinase
BW730_RS04780	COG0574	Belongs to the PEP-utilizing enzyme family
BW730_RS04835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BW730_RS04840	COG2884	Cell division ATP-binding protein ftsE
BW730_RS04850	COG1196	nuclear chromosome segregation
BW730_RS04850	COG0741	lytic transglycosylase activity
BW730_RS04850	COG0739	heme binding
BW730_RS04855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BW730_RS04870	COG1678	Uncharacterized ACR, COG1678
BW730_RS04890	COG0745	RESPONSE REGULATOR receiver
BW730_RS04895	COG5002	protein histidine kinase activity
BW730_RS04905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BW730_RS04910	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BW730_RS04915	COG0653	protein targeting
BW730_RS04930	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BW730_RS04950	COG0613	PHP domain protein
BW730_RS04980	COG1793	dna ligase
BW730_RS04980	COG3285	dna ligase
BW730_RS04995	COG0210	DNA helicase
BW730_RS05010	COG0187	DNA topoisomerase II activity
BW730_RS05015	COG1556	Lactate utilization protein
BW730_RS05020	COG1139	Iron-sulfur cluster binding protein
BW730_RS05025	COG0247	lactate metabolic process
BW730_RS05030	COG1620	l-lactate permease
BW730_RS05035	COG1802	Transcriptional regulator
BW730_RS05045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BW730_RS05075	COG1435	thymidine kinase activity
BW730_RS05100	COG0756	dUTP diphosphatase activity
BW730_RS05120	COG0569	domain protein
BW730_RS05125	COG0531	amino acid
BW730_RS05130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BW730_RS05140	COG0477	Major facilitator Superfamily
BW730_RS05150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BW730_RS05155	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BW730_RS05160	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BW730_RS05170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW730_RS05230	COG5006	permease, DMT superfamily
BW730_RS05235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BW730_RS05250	COG1024	Enoyl-CoA hydratase
BW730_RS05255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BW730_RS05270	COG0438	transferase activity, transferring glycosyl groups
BW730_RS05315	COG1295	ribonuclease BN
BW730_RS05335	COG0656	L-ascorbic acid biosynthetic process
BW730_RS05340	COG0009	L-threonylcarbamoyladenylate synthase
BW730_RS05355	COG0318	PFAM AMP-dependent synthetase and ligase
BW730_RS05370	COG1263	PTS System
BW730_RS05370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW730_RS05370	COG2190	(PTS) system
BW730_RS05380	COG0667	Aldo Keto reductase
BW730_RS05400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BW730_RS05405	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BW730_RS05420	COG3030	protein affecting phage T7 exclusion by the F plasmid
BW730_RS05425	COG1216	Glycosyl transferase, family 2
BW730_RS05430	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BW730_RS05435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BW730_RS05440	COG2813	Specifically methylates the guanine in position
BW730_RS05440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BW730_RS05445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BW730_RS05465	COG2873	o-acetylhomoserine
BW730_RS05470	COG0395	ABC-type sugar transport system, permease component
BW730_RS05475	COG1175	transmembrane transport
BW730_RS05480	COG1653	transport
BW730_RS05485	COG0647	UMP catabolic process
BW730_RS05520	COG2409	Drug exporters of the RND superfamily
BW730_RS05525	COG4585	Histidine kinase
BW730_RS05530	COG2197	response regulator
BW730_RS05550	COG0545	Peptidyl-prolyl cis-trans isomerase
BW730_RS05555	COG1621	beta-fructofuranosidase activity
BW730_RS05560	COG0395	ABC-type sugar transport system, permease component
BW730_RS05565	COG1175	transmembrane transport
BW730_RS05575	COG1609	Transcriptional regulator
BW730_RS05630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BW730_RS05705	COG4977	sequence-specific DNA binding
BW730_RS05705	COG1917	Cupin 2, conserved barrel domain protein
BW730_RS05755	COG0739	heme binding
BW730_RS05755	COG0741	lytic transglycosylase activity
BW730_RS05755	COG1196	nuclear chromosome segregation
BW730_RS05820	COG4974	Belongs to the 'phage' integrase family
BW730_RS05830	COG0500	methyltransferase
BW730_RS05845	COG1160	GTP binding
BW730_RS05855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BW730_RS05865	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BW730_RS05870	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BW730_RS05885	COG0646	methionine synthase
BW730_RS05885	COG1410	methionine synthase
BW730_RS05895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BW730_RS05900	COG3415	Transposase
BW730_RS05900	COG2801	Transposase and inactivated derivatives
BW730_RS05915	COG3189	MarR family transcriptional regulator
BW730_RS05930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BW730_RS05940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BW730_RS05945	COG1758	RNA polymerase activity
BW730_RS05950	COG0194	GDP metabolic process
BW730_RS05960	COG0284	orotidine-5'-phosphate decarboxylase activity
BW730_RS05965	COG0167	dihydroorotate dehydrogenase activity
BW730_RS05970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BW730_RS05975	COG0505	Belongs to the CarA family
BW730_RS05980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BW730_RS05985	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BW730_RS05990	COG4585	Histidine kinase
BW730_RS05995	COG2197	response regulator
BW730_RS06010	COG1690	Belongs to the RtcB family
BW730_RS06020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BW730_RS06025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BW730_RS06035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BW730_RS06050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BW730_RS06055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BW730_RS06095	COG2190	(PTS) system
BW730_RS06095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW730_RS06095	COG1263	PTS System
BW730_RS06105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BW730_RS06125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW730_RS06130	COG1196	nuclear chromosome segregation
BW730_RS06135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BW730_RS06150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BW730_RS06155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BW730_RS06160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BW730_RS06165	COG1862	Preprotein translocase
BW730_RS06170	COG2255	four-way junction helicase activity
BW730_RS06180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BW730_RS06185	COG0217	transcriptional regulatory protein
BW730_RS06215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BW730_RS06220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BW730_RS06225	COG0131	Imidazoleglycerol-phosphate dehydratase
BW730_RS06230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BW730_RS06235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BW730_RS06245	COG0587	DNA-directed DNA polymerase activity
BW730_RS06250	COG2985	domain, Protein
BW730_RS06250	COG0569	domain protein
BW730_RS06275	COG0395	ABC-type sugar transport system, permease component
BW730_RS06280	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BW730_RS06290	COG0698	ribose 5-phosphate isomerase
BW730_RS06300	COG0067	glutamate synthase
BW730_RS06300	COG0069	glutamate synthase activity
BW730_RS06300	COG0070	glutamate synthase
BW730_RS06340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BW730_RS06345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BW730_RS06350	COG2258	MOSC domain
BW730_RS06360	COG0133	tryptophan synthase activity
BW730_RS06385	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BW730_RS06390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BW730_RS06395	COG0154	amidase activity
BW730_RS06400	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BW730_RS06405	COG0596	Alpha beta hydrolase
BW730_RS06440	COG0366	Alpha amylase catalytic
BW730_RS06525	COG0596	Alpha beta hydrolase
BW730_RS06530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BW730_RS06555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BW730_RS06560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BW730_RS06570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BW730_RS06575	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BW730_RS06580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BW730_RS06605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BW730_RS06615	COG2890	protein-(glutamine-N5) methyltransferase activity
BW730_RS06620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BW730_RS06625	COG0254	rRNA binding
BW730_RS06640	COG0083	homoserine kinase activity
BW730_RS06645	COG0460	homoserine dehydrogenase
BW730_RS06670	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW730_RS06670	COG0567	Dehydrogenase, E1 component
BW730_RS06675	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BW730_RS06705	COG2135	peptidase activity
BW730_RS06720	COG1162	GTPase activity
BW730_RS06725	COG0483	inositol monophosphate 1-phosphatase activity
BW730_RS06730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BW730_RS06735	COG4608	Belongs to the ABC transporter superfamily
BW730_RS06740	COG0444	Belongs to the ABC transporter superfamily
BW730_RS06745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW730_RS06755	COG0747	negative chemotaxis
BW730_RS06760	COG4129	membrane
BW730_RS06780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW730_RS06795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BW730_RS06805	COG2376	Dihydroxyacetone kinase
BW730_RS06830	COG2205	protein histidine kinase activity
BW730_RS06865	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BW730_RS06910	COG2255	four-way junction helicase activity
BW730_RS06960	COG1115	amino acid carrier protein
BW730_RS06965	COG0667	Aldo Keto reductase
BW730_RS06985	COG1615	UPF0182 protein
BW730_RS06995	COG3480	Lon protease (S16) C-terminal proteolytic domain
BW730_RS07025	COG1074	ATP-dependent DNA helicase activity
BW730_RS07045	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BW730_RS07055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BW730_RS07065	COG1946	Acyl-CoA thioesterase
BW730_RS07070	COG1643	Atp-dependent helicase
BW730_RS07110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BW730_RS07110	COG1648	precorrin-2 dehydrogenase activity
BW730_RS07115	COG1797	cobyrinic acid a,c-diamide synthase activity
BW730_RS07120	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BW730_RS07135	COG0395	ABC-type sugar transport system, permease component
BW730_RS07140	COG1175	transmembrane transport
BW730_RS07145	COG1653	transport
BW730_RS07150	COG1609	Transcriptional regulator
BW730_RS07170	COG0310	cobalt ion transport
BW730_RS07185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BW730_RS07185	COG1648	precorrin-2 dehydrogenase activity
BW730_RS07205	COG4989	oxidoreductase activity
BW730_RS07210	COG1492	cobalamin metabolic process
BW730_RS07215	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BW730_RS07220	COG0406	alpha-ribazole phosphatase activity
BW730_RS07230	COG0598	Magnesium transport protein CorA
BW730_RS07235	COG0598	Magnesium transport protein CorA
BW730_RS07245	COG0129	dihydroxy-acid dehydratase activity
BW730_RS07255	COG5426	von Willebrand factor, type A
BW730_RS07270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BW730_RS07275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BW730_RS07280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BW730_RS07285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW730_RS07290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BW730_RS07300	COG2217	Heavy metal translocating P-type atpase
BW730_RS07305	COG0488	(ABC) transporter
BW730_RS07310	COG2197	response regulator
BW730_RS07330	COG2267	carboxylic ester hydrolase activity
BW730_RS07340	COG0822	iron-sulfur transferase activity
BW730_RS07345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BW730_RS07350	COG0396	ATPase activity
BW730_RS07385	COG1612	heme a metabolic process
BW730_RS07420	COG1136	(ABC) transporter
BW730_RS07450	COG0109	protoheme IX farnesyltransferase activity
BW730_RS07465	COG0363	glucosamine-6-phosphate deaminase activity
BW730_RS07480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BW730_RS07485	COG0149	triose-phosphate isomerase activity
BW730_RS07490	COG0126	phosphoglycerate kinase activity
BW730_RS07495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BW730_RS07500	COG1481	regulation of sporulation
BW730_RS07510	COG1660	Displays ATPase and GTPase activities
BW730_RS07515	COG3104	oligopeptide transport
BW730_RS07525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BW730_RS07530	COG1122	ATPase activity
BW730_RS07535	COG1268	BioY protein
BW730_RS07540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BW730_RS07545	COG0583	DNA-binding transcription factor activity
BW730_RS07565	COG0395	ABC-type sugar transport system, permease component
BW730_RS07570	COG0322	excinuclease ABC activity
BW730_RS07580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BW730_RS07600	COG0556	nucleotide-excision repair
BW730_RS07605	COG0589	response to stress
BW730_RS07605	COG0475	glutathione-regulated potassium exporter activity
BW730_RS07620	COG0509	glycine decarboxylation via glycine cleavage system
BW730_RS07625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BW730_RS07625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BW730_RS07635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BW730_RS07640	COG0477	Major facilitator Superfamily
BW730_RS07650	COG0237	dephospho-CoA kinase activity
BW730_RS07665	COG3119	arylsulfatase activity
BW730_RS07670	COG0395	ABC-type sugar transport system, permease component
BW730_RS07675	COG1175	transmembrane transport
BW730_RS07680	COG1653	transport
BW730_RS07685	COG1609	Transcriptional regulator
BW730_RS07695	COG0539	negative regulation of cytoplasmic translation
BW730_RS07710	COG2050	protein possibly involved in aromatic compounds catabolism
BW730_RS07725	COG0469	pyruvate kinase activity
BW730_RS07750	COG1799	cell septum assembly
BW730_RS07760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BW730_RS07765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BW730_RS07780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BW730_RS07785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BW730_RS07790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BW730_RS07800	COG0768	penicillin binding
BW730_RS07810	COG0275	rRNA processing
BW730_RS07815	COG2001	Belongs to the MraZ family
BW730_RS07820	COG0714	Associated with various cellular activities
BW730_RS07885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BW730_RS07885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BW730_RS07890	COG3973	AAA domain
BW730_RS07915	COG0515	serine threonine protein kinase
BW730_RS07915	COG2815	serine threonine protein kinase
BW730_RS07920	COG0515	serine threonine protein kinase
BW730_RS07920	COG2815	serine threonine protein kinase
BW730_RS07925	COG3250	beta-galactosidase activity
BW730_RS07945	COG1609	Transcriptional regulator
BW730_RS07955	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BW730_RS07965	COG2197	response regulator
BW730_RS07990	COG0280	phosphate acetyltransferase
BW730_RS07990	COG0857	belongs to the CobB CobQ family
BW730_RS08000	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BW730_RS08025	COG1012	belongs to the aldehyde dehydrogenase family
BW730_RS08025	COG1454	alcohol dehydrogenase
BW730_RS08030	COG4816	utilization protein
BW730_RS08035	COG4302	ethanolamine ammonia-lyase activity
BW730_RS08040	COG4303	Ethanolamine ammonia lyase large subunit
BW730_RS08050	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
BW730_RS08085	COG0088	Forms part of the polypeptide exit tunnel
BW730_RS08090	COG3214	Protein conserved in bacteria
BW730_RS08110	COG1845	cytochrome c oxidase, subunit III
BW730_RS08120	COG0723	plastoquinol--plastocyanin reductase activity
BW730_RS08125	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BW730_RS08130	COG3831	ATPase activity
BW730_RS08135	COG0714	Associated with various cellular activities
BW730_RS08170	COG1191	sigma factor activity
BW730_RS08180	COG0673	inositol 2-dehydrogenase activity
BW730_RS08190	COG0745	RESPONSE REGULATOR receiver
BW730_RS08195	COG1840	ABC-type Fe3 transport system, periplasmic component
BW730_RS08200	COG4149	molybdate abc transporter
BW730_RS08205	COG3842	ATPase activity
BW730_RS08240	COG4585	Histidine kinase
BW730_RS08245	COG2197	response regulator
BW730_RS08250	COG4152	abc transporter atp-binding protein
BW730_RS08255	COG1668	transmembrane transport
BW730_RS08265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BW730_RS08270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BW730_RS08325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW730_RS08330	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW730_RS08345	COG0321	lipoyl(octanoyl) transferase activity
BW730_RS08350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BW730_RS08360	COG0488	(ABC) transporter
BW730_RS08370	COG0534	Mate efflux family protein
BW730_RS08380	COG1012	belongs to the aldehyde dehydrogenase family
BW730_RS08390	COG2723	6-phospho-beta-galactosidase activity
BW730_RS08415	COG1136	(ABC) transporter
BW730_RS08435	COG0656	L-ascorbic acid biosynthetic process
BW730_RS08450	COG1823	symporter activity
BW730_RS08455	COG0174	glutamine synthetase
BW730_RS08460	COG2409	Drug exporters of the RND superfamily
BW730_RS08470	COG0604	alcohol dehydrogenase
BW730_RS08485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BW730_RS08490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BW730_RS08500	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BW730_RS08510	COG0174	glutamine synthetase
BW730_RS08525	COG1595	DNA-templated transcription, initiation
BW730_RS08600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW730_RS08605	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BW730_RS08610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BW730_RS08635	COG3304	Inner membrane component domain
BW730_RS08640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BW730_RS08645	COG0101	tRNA pseudouridine synthase activity
BW730_RS08650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BW730_RS08660	COG2755	lipolytic protein G-D-S-L family
BW730_RS08660	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BW730_RS08680	COG1609	Transcriptional regulator
BW730_RS08685	COG1116	anion transmembrane transporter activity
BW730_RS08690	COG4120	Belongs to the binding-protein-dependent transport system permease family
BW730_RS08700	COG0203	ribosomal protein L17
BW730_RS08705	COG0202	RNA polymerase activity
BW730_RS08710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BW730_RS08715	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BW730_RS08720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BW730_RS08725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BW730_RS08730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BW730_RS08740	COG3459	Glycosyltransferase 36 associated
BW730_RS08745	COG1609	Transcriptional regulator
BW730_RS08755	COG1175	transmembrane transport
BW730_RS08760	COG0395	ABC-type sugar transport system, permease component
BW730_RS08790	COG0024	Methionine aminopeptidase
BW730_RS08795	COG0563	adenylate kinase activity
BW730_RS08800	COG0201	protein transport
BW730_RS08810	COG1841	ribosomal large subunit assembly
BW730_RS08815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BW730_RS08820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BW730_RS08825	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BW730_RS08830	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BW730_RS08835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BW730_RS08840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BW730_RS08845	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BW730_RS08850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BW730_RS08860	COG1950	PFAM Membrane protein of
BW730_RS08875	COG1653	transport
BW730_RS08880	COG0366	Alpha amylase catalytic
BW730_RS08885	COG1609	Transcriptional regulator
BW730_RS08890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BW730_RS08895	COG0255	Belongs to the universal ribosomal protein uL29 family
BW730_RS08900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BW730_RS08905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BW730_RS08910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BW730_RS08915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BW730_RS08920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BW730_RS08925	COG0089	rRNA binding
BW730_RS08930	COG0088	Forms part of the polypeptide exit tunnel
BW730_RS08935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BW730_RS08940	COG0051	transcription antitermination factor activity, RNA binding
BW730_RS08955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BW730_RS08970	COG0494	nUDIX hydrolase
BW730_RS08975	COG3620	sequence-specific DNA binding
BW730_RS08975	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BW730_RS08975	COG0617	tRNA 3'-terminal CCA addition
BW730_RS09020	COG0435	Glutathione S-transferase
BW730_RS09040	COG2837	iron assimilation
BW730_RS09045	COG0281	malic enzyme
BW730_RS09060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BW730_RS09085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BW730_RS09095	COG0049	tRNA binding
BW730_RS09100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BW730_RS09110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BW730_RS09120	COG0222	ribosome binding
BW730_RS09125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BW730_RS09140	COG0765	amino acid transport
BW730_RS09145	COG1126	abc transporter atp-binding protein
BW730_RS09155	COG0395	ABC-type sugar transport system, permease component
BW730_RS09160	COG1175	transmembrane transport
BW730_RS09165	COG1653	transport
BW730_RS09170	COG1609	Transcriptional regulator
BW730_RS09175	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BW730_RS09180	COG0081	regulation of translation
BW730_RS09185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BW730_RS09190	COG0250	Participates in transcription elongation, termination and antitermination
BW730_RS09210	COG1132	(ABC) transporter
BW730_RS09215	COG1132	(ABC) transporter
BW730_RS09220	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BW730_RS09225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BW730_RS09230	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BW730_RS09235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BW730_RS09245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BW730_RS09295	COG0515	serine threonine protein kinase
BW730_RS09295	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BW730_RS09320	COG2835	tetraacyldisaccharide 4'-kinase activity
BW730_RS09365	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BW730_RS09365	COG0662	Cupin 2, conserved barrel domain protein
BW730_RS09395	COG1316	TRANSCRIPTIONal
BW730_RS09425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BW730_RS09435	COG0424	maF-like protein
BW730_RS09445	COG1595	DNA-templated transcription, initiation
BW730_RS09465	COG4770	biotin carboxylase activity
BW730_RS09475	COG1609	Transcriptional regulator
BW730_RS09490	COG1175	transmembrane transport
BW730_RS09515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BW730_RS09530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW730_RS09560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW730_RS09595	COG1175	transmembrane transport
BW730_RS09600	COG0395	ABC-type sugar transport system, permease component
BW730_RS09610	COG0328	RNA-DNA hybrid ribonuclease activity
BW730_RS09615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BW730_RS09650	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BW730_RS09660	COG1079	Belongs to the binding-protein-dependent transport system permease family
BW730_RS09665	COG4603	Belongs to the binding-protein-dependent transport system permease family
BW730_RS09670	COG3845	ABC transporter
BW730_RS09675	COG1744	ABC transporter substrate-binding protein PnrA-like
BW730_RS09700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BW730_RS09705	COG0039	L-malate dehydrogenase activity
BW730_RS09720	COG1486	melibiose metabolic process
BW730_RS09735	COG1175	transmembrane transport
BW730_RS09740	COG0395	ABC-type sugar transport system, permease component
BW730_RS09750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW730_RS09760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BW730_RS09765	COG0138	bifunctional purine biosynthesis protein purh
BW730_RS09790	COG0045	succinate-CoA ligase (ADP-forming) activity
BW730_RS09805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BW730_RS09820	COG3119	arylsulfatase activity
BW730_RS09825	COG0395	ABC-type sugar transport system, permease component
BW730_RS09830	COG1175	transmembrane transport
BW730_RS09850	COG2197	response regulator
BW730_RS09895	COG1131	(ABC) transporter
BW730_RS09905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BW730_RS09920	COG0287	Prephenate dehydrogenase
BW730_RS09920	COG1605	Chorismate mutase
BW730_RS09925	COG0516	GMP reductase activity
BW730_RS09955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BW730_RS09980	COG0210	DNA helicase
BW730_RS09985	COG0459	protein refolding
BW730_RS09990	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BW730_RS10000	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BW730_RS10020	COG3845	ABC transporter
BW730_RS10035	COG2816	NAD+ diphosphatase activity
BW730_RS10055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW730_RS10060	COG0601	transmembrane transport
BW730_RS10065	COG4166	transmembrane transport
BW730_RS10070	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BW730_RS10085	COG0802	atpase or kinase
BW730_RS10090	COG0513	Belongs to the DEAD box helicase family
BW730_RS10105	COG0736	holo-[acyl-carrier-protein] synthase activity
BW730_RS10115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BW730_RS10120	COG1072	(Pantothenic acid kinase))
BW730_RS10125	COG2860	membrane
BW730_RS10150	COG2239	Acts as a magnesium transporter
BW730_RS10170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BW730_RS10175	COG3328	transposase activity
BW730_RS10180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BW730_RS10195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BW730_RS10205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BW730_RS10210	COG0297	glycogen (starch) synthase activity
BW730_RS10225	COG1611	Belongs to the LOG family
BW730_RS10230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BW730_RS10250	COG1305	Transglutaminase-like
BW730_RS10265	COG1054	Belongs to the UPF0176 family
BW730_RS10295	COG2171	N-acyltransferase activity
BW730_RS10325	COG0616	signal peptide processing
BW730_RS10330	COG2826	transposase and inactivated derivatives, IS30 family
BW730_RS10345	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BW730_RS10380	COG1335	isochorismatase
BW730_RS10410	COG0517	IMP dehydrogenase activity
BW730_RS10435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW730_RS10440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW730_RS10450	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BW730_RS10455	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW730_RS10455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW730_RS10460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW730_RS10470	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BW730_RS10475	COG0598	Magnesium transport protein CorA
BW730_RS10505	COG1045	serine acetyltransferase
BW730_RS10520	COG1940	carbohydrate kinase activity
BW730_RS10525	COG0395	ABC-type sugar transport system, permease component
BW730_RS10540	COG1940	carbohydrate kinase activity
BW730_RS10575	COG1230	cation diffusion facilitator family transporter
BW730_RS10635	COG2226	methyltransferase
BW730_RS10645	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BW730_RS10675	COG0456	acetyltransferase
BW730_RS10695	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BW730_RS10715	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BW730_RS10770	COG1660	Displays ATPase and GTPase activities
BW730_RS10810	COG0012	GTP binding
BW730_RS10835	COG1362	aminopeptidase activity
BW730_RS10845	COG1322	Protein conserved in bacteria
BW730_RS10855	COG3693	PFAM glycoside hydrolase, family 10
BW730_RS10860	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BW730_RS10870	COG0561	phosphatase activity
BW730_RS10875	COG1570	exodeoxyribonuclease VII activity
BW730_RS10880	COG1722	exodeoxyribonuclease VII activity
BW730_RS10890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BW730_RS10905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BW730_RS10930	COG3119	arylsulfatase activity
BW730_RS10945	COG0666	response to abiotic stimulus
BW730_RS10965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW730_RS10975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BW730_RS11010	COG0395	ABC-type sugar transport system, permease component
BW730_RS11015	COG1175	transmembrane transport
BW730_RS11030	COG1609	Transcriptional regulator
BW730_RS11040	COG1254	Belongs to the acylphosphatase family
BW730_RS11065	COG0494	nUDIX hydrolase
BW730_RS11075	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BW730_RS11085	COG1793	dna ligase
BW730_RS11110	COG2268	Band 7 protein
BW730_RS11115	COG2198	Histidine kinase
BW730_RS11115	COG5002	protein histidine kinase activity
BW730_RS11115	COG0784	Response regulator, receiver
BW730_RS11120	COG0745	RESPONSE REGULATOR receiver
BW730_RS11170	COG0148	phosphopyruvate hydratase activity
BW730_RS11175	COG3956	TIGRFAM MazG family protein
BW730_RS11195	COG0193	aminoacyl-tRNA hydrolase activity
BW730_RS11200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BW730_RS11205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BW730_RS11210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BW730_RS11210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BW730_RS11215	COG1609	Transcriptional regulator
BW730_RS11225	COG1070	Carbohydrate kinase
BW730_RS11235	COG0577	efflux transmembrane transporter activity
BW730_RS11235	COG1136	(ABC) transporter
BW730_RS11240	COG0577	efflux transmembrane transporter activity
BW730_RS11240	COG1136	(ABC) transporter
BW730_RS11255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BW730_RS11260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BW730_RS11275	COG2818	Glycosylase
BW730_RS11280	COG1309	transcriptional regulator
BW730_RS11285	COG1846	Transcriptional regulator
BW730_RS11290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BW730_RS11295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BW730_RS11300	COG0084	hydrolase, TatD family'
BW730_RS11320	COG2233	PERMEase
BW730_RS11325	COG1940	carbohydrate kinase activity
BW730_RS11370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BW730_RS11385	COG2217	Heavy metal translocating P-type atpase
BW730_RS11395	COG3250	beta-galactosidase activity
BW730_RS11400	COG3507	Belongs to the glycosyl hydrolase 43 family
BW730_RS11410	COG2723	6-phospho-beta-galactosidase activity
BW730_RS11415	COG4172	Belongs to the ABC transporter superfamily
BW730_RS11425	COG0601	transmembrane transport
BW730_RS11435	COG1309	transcriptional regulator
BW730_RS11470	COG1970	mechanosensitive ion channel activity
BW730_RS11545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BW730_RS11545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BW730_RS11545	COG1013	pyruvate-flavodoxin oxidoreductase activity
BW730_RS11545	COG0674	pyruvate-flavodoxin oxidoreductase activity
BW730_RS11555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW730_RS11560	COG2226	methyltransferase
BW730_RS11565	COG1321	iron dependent repressor
BW730_RS11580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BW730_RS11600	COG2252	PERMEase
BW730_RS11610	COG1278	Cold shock
BW730_RS11615	COG0363	glucosamine-6-phosphate deaminase activity
BW730_RS11695	COG2197	response regulator
BW730_RS11705	COG3842	ATPase activity
BW730_RS11710	COG0626	cystathionine gamma-synthase activity
BW730_RS11730	COG1929	Belongs to the glycerate kinase type-1 family
BW730_RS11735	COG1609	Transcriptional regulator
BW730_RS11750	COG0673	inositol 2-dehydrogenase activity
BW730_RS11770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BW730_RS11790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BW730_RS11795	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BW730_RS11800	COG1329	Transcriptional regulator
BW730_RS11825	COG0726	polysaccharide deacetylase
BW730_RS11830	COG0588	phosphoglycerate mutase activity
BW730_RS11835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BW730_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
BW730_RS11845	COG4948	Mandelate Racemase Muconate Lactonizing
BW730_RS11850	COG3833	ABC-type maltose transport systems, permease component
BW730_RS11915	COG1609	Transcriptional regulator
BW730_RS11920	COG0246	Mannitol dehydrogenase
BW730_RS11940	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS11945	COG1129	ABC transporter
BW730_RS11960	COG1051	belongs to the nudix hydrolase family
BW730_RS11980	COG1028	Short-chain dehydrogenase reductase Sdr
BW730_RS11990	COG0022	dehydrogenase e1 component
BW730_RS11995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW730_RS12000	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW730_RS12005	COG1349	DNA-binding transcription factor activity
BW730_RS12045	COG1595	DNA-templated transcription, initiation
BW730_RS12080	COG3958	Transketolase
BW730_RS12085	COG3959	Transketolase, thiamine diphosphate binding domain
BW730_RS12090	COG1082	Xylose isomerase domain protein TIM barrel
BW730_RS12100	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS12105	COG1129	ABC transporter
BW730_RS12115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BW730_RS12125	COG1609	Transcriptional regulator
BW730_RS12130	COG1070	Carbohydrate kinase
BW730_RS12145	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS12170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BW730_RS12180	COG1716	ATPase activity
BW730_RS12200	COG0768	penicillin binding
BW730_RS12205	COG0515	serine threonine protein kinase
BW730_RS12225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BW730_RS12230	COG0393	Putative heavy-metal-binding
BW730_RS12235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BW730_RS12290	COG2514	catechol 2,3-dioxygenase activity
BW730_RS12295	COG2326	polyphosphate kinase activity
BW730_RS12300	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BW730_RS12310	COG1271	oxidase subunit
BW730_RS12315	COG1294	oxidase, subunit
BW730_RS12325	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BW730_RS12340	COG1609	Transcriptional regulator
BW730_RS12350	COG0395	ABC-type sugar transport system, permease component
BW730_RS12370	COG0114	fumarate hydratase activity
BW730_RS12375	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BW730_RS12385	COG1937	Protein conserved in bacteria
BW730_RS12390	COG0305	Participates in initiation and elongation during chromosome replication
BW730_RS12420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BW730_RS12425	COG1742	UPF0060 membrane protein
BW730_RS12440	COG3764	Sortase (surface protein transpeptidase)
BW730_RS12470	COG1397	ADP-ribosylglycohydrolase
BW730_RS12475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW730_RS12480	COG0686	Belongs to the AlaDH PNT family
BW730_RS12535	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS12540	COG1129	ABC transporter
BW730_RS12555	COG0006	proline dipeptidase activity
BW730_RS12565	COG1393	Belongs to the ArsC family
BW730_RS12575	COG1120	ATPase activity
BW730_RS12580	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW730_RS12585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW730_RS12635	COG1597	lipid kinase activity
BW730_RS12680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW730_RS12690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW730_RS12705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW730_RS12730	COG1595	DNA-templated transcription, initiation
BW730_RS12780	COG1609	Transcriptional regulator
BW730_RS12790	COG1472	Belongs to the glycosyl hydrolase 3 family
BW730_RS12795	COG1472	Belongs to the glycosyl hydrolase 3 family
BW730_RS12820	COG2066	Belongs to the glutaminase family
BW730_RS12840	COG0745	RESPONSE REGULATOR receiver
BW730_RS12845	COG5002	protein histidine kinase activity
BW730_RS12855	COG3158	transport of potassium into the cell
BW730_RS12860	COG0439	Biotin carboxylase
BW730_RS12900	COG1132	(ABC) transporter
BW730_RS12905	COG0641	radical SAM
BW730_RS12935	COG4213	ABC transporter substrate-binding protein
BW730_RS12945	COG4214	carbohydrate transport
BW730_RS12960	COG0318	PFAM AMP-dependent synthetase and ligase
BW730_RS12975	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BW730_RS13010	COG1064	alcohol dehydrogenase
BW730_RS13055	COG1388	LysM domain
BW730_RS13075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BW730_RS13085	COG2197	response regulator
BW730_RS13135	COG3655	Transcriptional regulator
BW730_RS13160	COG0346	lactoylglutathione lyase activity
BW730_RS13165	COG0402	S-adenosylhomocysteine deaminase activity
BW730_RS13170	COG1846	Transcriptional regulator
BW730_RS13185	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BW730_RS13255	COG0513	Belongs to the DEAD box helicase family
BW730_RS13280	COG1175	transmembrane transport
BW730_RS13285	COG0395	ABC-type sugar transport system, permease component
BW730_RS13310	COG4608	Belongs to the ABC transporter superfamily
BW730_RS13320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW730_RS13360	COG0371	Dehydrogenase
BW730_RS13365	COG0647	UMP catabolic process
BW730_RS13375	COG1840	ABC-type Fe3 transport system, periplasmic component
BW730_RS13385	COG3842	ATPase activity
BW730_RS13390	COG2390	Transcriptional regulator
BW730_RS13400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BW730_RS13410	COG0300	oxidoreductase activity
BW730_RS13435	COG4585	Histidine kinase
BW730_RS13455	COG0420	3'-5' exonuclease activity
BW730_RS13460	COG0419	ATPase involved in DNA repair
BW730_RS13475	COG3842	ATPase activity
BW730_RS13490	COG1840	ABC-type Fe3 transport system, periplasmic component
BW730_RS13495	COG1764	response to oxidative stress
BW730_RS13500	COG1940	carbohydrate kinase activity
BW730_RS13505	COG3345	alpha-galactosidase
BW730_RS13520	COG1278	Cold shock
BW730_RS13525	COG0395	ABC-type sugar transport system, permease component
BW730_RS13530	COG1175	transmembrane transport
BW730_RS13570	COG2226	methyltransferase
BW730_RS13600	COG0242	peptide deformylase activity
BW730_RS13605	COG0714	Associated with various cellular activities
BW730_RS13645	COG1132	(ABC) transporter
BW730_RS13655	COG1136	(ABC) transporter
BW730_RS13655	COG0577	efflux transmembrane transporter activity
BW730_RS13765	COG1090	epimerase
BW730_RS13770	COG0705	Rhomboid family
BW730_RS13770	COG0457	Tetratricopeptide repeat
BW730_RS13785	COG2814	Major facilitator Superfamily
BW730_RS13815	COG2826	transposase and inactivated derivatives, IS30 family
BW730_RS13820	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BW730_RS13830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BW730_RS13840	COG2188	Transcriptional regulator
BW730_RS13850	COG0673	inositol 2-dehydrogenase activity
BW730_RS13855	COG1414	Transcriptional regulator
BW730_RS13875	COG0673	inositol 2-dehydrogenase activity
BW730_RS13880	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS13885	COG1129	ABC transporter
BW730_RS13895	COG2115	Belongs to the xylose isomerase family
BW730_RS13900	COG1940	carbohydrate kinase activity
BW730_RS13905	COG0673	inositol 2-dehydrogenase activity
BW730_RS13910	COG0673	inositol 2-dehydrogenase activity
BW730_RS13920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BW730_RS13950	COG1082	Xylose isomerase domain protein TIM barrel
BW730_RS13955	COG0673	inositol 2-dehydrogenase activity
BW730_RS13960	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS13965	COG1129	ABC transporter
BW730_RS13970	COG1879	ABC-type sugar transport system periplasmic component
BW730_RS13985	COG1082	Xylose isomerase domain protein TIM barrel
BW730_RS13990	COG3962	Belongs to the TPP enzyme family
BW730_RS13995	COG3718	enzyme involved in inositol metabolism
BW730_RS14020	COG0673	inositol 2-dehydrogenase activity
BW730_RS14080	COG5564	TIM-barrel signal transduction protein
BW730_RS14095	COG1131	(ABC) transporter
BW730_RS14100	COG3559	Exporter of polyketide antibiotics
BW730_RS14105	COG3177	Filamentation induced by cAMP protein fic
BW730_RS14110	COG1715	Restriction endonuclease
BW730_RS14135	COG0732	type I restriction modification DNA specificity domain
BW730_RS14140	COG3328	transposase activity
BW730_RS14175	COG5290	Psort location Cytoplasmic, score
BW730_RS14190	COG3328	transposase activity
BW730_RS14210	COG3547	Transposase (IS116 IS110 IS902 family)
BW730_RS14315	COG1609	Transcriptional regulator
BW730_RS14325	COG3842	ATPase activity
BW730_RS14335	COG1840	ABC-type Fe3 transport system, periplasmic component
BW730_RS14360	COG0584	glycerophosphoryl diester phosphodiesterase
BW730_RS14380	COG1874	Beta-galactosidase
BW730_RS14395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BW730_RS14400	COG1335	isochorismatase
BW730_RS14405	COG2390	Transcriptional regulator
BW730_RS14415	COG0492	ferredoxin-NADP+ reductase activity
BW730_RS14435	COG1181	Belongs to the D-alanine--D-alanine ligase family
BW730_RS14470	COG0357	Ribosomal RNA small subunit methyltransferase G
BW730_RS14480	COG0706	membrane insertase activity
BW730_RS14485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BW730_RS14490	COG0594	ribonuclease P activity
BW730_RS14495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BW730_RS14500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BW730_RS14505	COG2226	methyltransferase
BW730_RS14515	COG1136	(ABC) transporter
BW730_RS14520	COG0577	efflux transmembrane transporter activity
BW730_RS14520	COG1136	(ABC) transporter
BW730_RS14525	COG0592	DNA-directed DNA polymerase activity
BW730_RS14530	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BW730_RS14535	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BW730_RS14545	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
BW730_RS14570	COG0741	lytic transglycosylase activity
BW730_RS14570	COG0739	heme binding
BW730_RS14570	COG1196	nuclear chromosome segregation
BW730_RS14595	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BW730_RS14600	COG3266	domain, Protein
BW730_RS14675	COG1053	succinate dehydrogenase
BW730_RS14715	COG1518	maintenance of DNA repeat elements
BW730_RS14760	COG2354	Protein conserved in bacteria
BW730_RS14765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BW730_RS14775	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BW730_RS14780	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BW730_RS14805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW730_RS14815	COG2076	Multidrug Resistance protein
BW730_RS14835	COG0640	Transcriptional regulator
BW730_RS14865	COG2197	response regulator
BW730_RS14875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BW730_RS14890	COG2409	Drug exporters of the RND superfamily
BW730_RS14935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BW730_RS14940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BW730_RS14950	COG1349	DNA-binding transcription factor activity
BW730_RS14975	COG1028	Short-chain dehydrogenase reductase Sdr
BW730_RS14980	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BW730_RS14990	COG3422	double-strand break repair
BW730_RS15015	COG1793	dna ligase
BW730_RS15050	COG0672	)-iron permease
BW730_RS15055	COG2822	iron ion transport
BW730_RS15060	COG2837	iron assimilation
BW730_RS15095	COG0617	tRNA 3'-terminal CCA addition
BW730_RS15100	COG0668	transmembrane transport
BW730_RS15115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW730_RS15125	COG2318	DinB family
BW730_RS15135	COG2318	DinB family
BW730_RS15165	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BW730_RS15180	COG4214	carbohydrate transport
BW730_RS15215	COG1349	DNA-binding transcription factor activity
BW730_RS15220	COG2814	Major facilitator Superfamily
BW730_RS15225	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BW730_RS15230	COG0574	Belongs to the PEP-utilizing enzyme family
BW730_RS15230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BW730_RS15260	COG0318	PFAM AMP-dependent synthetase and ligase
BW730_RS15260	COG0204	Acyl-transferase
BW730_RS15285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW730_RS15290	COG2154	pterin-4-alpha-carbinolamine dehydratase
BW730_RS15300	COG1320	monovalent cation:proton antiporter activity
BW730_RS15310	COG1863	multisubunit Na H antiporter MnhE subunit
BW730_RS15315	COG0651	ATP synthesis coupled electron transport
BW730_RS15320	COG1006	Multisubunit Na H antiporter MnhC subunit
BW730_RS15330	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BW730_RS15335	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BW730_RS15340	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BW730_RS15345	COG0488	(ABC) transporter
BW730_RS15370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BW730_RS15380	COG0360	Binds together with S18 to 16S ribosomal RNA
BW730_RS15390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BW730_RS15395	COG0359	binds to the 23S rRNA
BW730_RS15400	COG0501	Belongs to the peptidase M48B family
BW730_RS15435	COG1760	l-serine dehydratase
BW730_RS15440	COG2814	Major facilitator Superfamily
BW730_RS15505	COG2184	nucleotidyltransferase activity
BW730_RS15510	COG0789	Transcriptional regulator
BW730_RS15540	COG4591	ABC-type transport system involved in lipoprotein release permease component
BW730_RS15540	COG1136	(ABC) transporter
BW730_RS15570	COG0028	Belongs to the TPP enzyme family
BW730_RS15585	COG3848	Pyruvate phosphate dikinase
BW730_RS15585	COG0574	Belongs to the PEP-utilizing enzyme family
BW730_RS15590	COG1028	Short-chain dehydrogenase reductase Sdr
BW730_RS15630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BW730_RS15650	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BW730_RS15700	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BW730_RS15705	COG0028	Belongs to the TPP enzyme family
BW730_RS15715	COG1609	Transcriptional regulator
BW730_RS15745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BW730_RS15750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BW730_RS15765	COG3212	peptidase
BW730_RS15790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BW730_RS15795	COG0737	Belongs to the 5'-nucleotidase family
BW730_RS15805	COG0022	dehydrogenase e1 component
BW730_RS15810	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW730_RS15820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BW730_RS15830	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BW730_RS15835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BW730_RS15880	COG1674	ftsk spoiiie
BW730_RS15885	COG1404	Belongs to the peptidase S8 family
BW730_RS15910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BW730_RS15915	COG0561	phosphatase activity
BW730_RS15925	COG1134	teichoic acid transport
BW730_RS15940	COG0438	transferase activity, transferring glycosyl groups
BW730_RS15945	COG0438	transferase activity, transferring glycosyl groups
BW730_RS15950	COG1215	transferase activity, transferring glycosyl groups
BW730_RS15950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BW730_RS15955	COG0438	transferase activity, transferring glycosyl groups
BW730_RS15970	COG0137	argininosuccinate synthase activity
BW730_RS15975	COG0438	transferase activity, transferring glycosyl groups
BW730_RS15995	COG0438	transferase activity, transferring glycosyl groups
BW730_RS16055	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BW730_RS16065	COG0564	pseudouridine synthase activity
BW730_RS16080	COG1316	TRANSCRIPTIONal
BW730_RS16100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BW730_RS16115	COG0383	alpha-mannosidase activity
BW730_RS16125	COG3833	ABC-type maltose transport systems, permease component
BW730_RS16130	COG1175	transmembrane transport
BW730_RS16150	COG1082	Xylose isomerase domain protein TIM barrel
BW730_RS16190	COG0584	glycerophosphoryl diester phosphodiesterase
BW730_RS16195	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BW730_RS16210	COG0673	inositol 2-dehydrogenase activity
BW730_RS16220	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW730_RS16225	COG1129	ABC transporter
BW730_RS16255	COG0800	Aldolase
BW730_RS16265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BW730_RS16290	COG0395	ABC-type sugar transport system, permease component
BW730_RS16295	COG1175	transmembrane transport
BW730_RS16300	COG1653	transport
BW730_RS16305	COG1609	Transcriptional regulator
BW730_RS16310	COG1597	lipid kinase activity
BW730_RS16335	COG1653	transport
BW730_RS16345	COG3132	Protein of unknown function, DUF480
BW730_RS16370	COG1316	TRANSCRIPTIONal
BW730_RS16375	COG1086	Polysaccharide biosynthesis protein
BW730_RS16390	COG0297	glycogen (starch) synthase activity
BW730_RS16410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BW730_RS16425	COG0489	protein tyrosine kinase activity
BW730_RS16430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BW730_RS16455	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BW730_RS16475	COG0714	Associated with various cellular activities
BW730_RS16510	COG0717	Belongs to the dCTP deaminase family
BW730_RS16515	COG2827	Endonuclease containing a URI domain
BW730_RS16520	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BW730_RS16525	COG2205	protein histidine kinase activity
BW730_RS16530	COG0745	RESPONSE REGULATOR receiver
BW730_RS16540	COG1252	NADH dehydrogenase
BW730_RS16560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BW730_RS16585	COG1316	TRANSCRIPTIONal
BW730_RS16610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BW730_RS16615	COG0484	heat shock protein binding
BW730_RS16620	COG0789	Transcriptional regulator
BW730_RS16635	COG0673	inositol 2-dehydrogenase activity
BW730_RS16665	COG0058	SHG alpha-glucan phosphorylase activity
BW730_RS16670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BW730_RS16670	COG0351	phosphomethylpyrimidine kinase
BW730_RS16670	COG0352	thiamine-phosphate diphosphorylase activity
BW730_RS16675	COG0351	phosphomethylpyrimidine kinase
BW730_RS16680	COG0351	phosphomethylpyrimidine kinase
BW730_RS16680	COG0352	thiamine-phosphate diphosphorylase activity
BW730_RS16680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BW730_RS16690	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BW730_RS16715	COG1175	transmembrane transport
BW730_RS16720	COG0395	ABC-type sugar transport system, permease component
BW730_RS16730	COG0156	8-amino-7-oxononanoate synthase activity
BW730_RS16735	COG1063	alcohol dehydrogenase
BW730_RS16745	COG0642	Histidine kinase
BW730_RS16750	COG2197	response regulator
BW730_RS16755	COG1136	(ABC) transporter
BW730_RS16755	COG4591	ABC-type transport system involved in lipoprotein release permease component
BW730_RS16765	COG0542	response to heat
BW730_RS16785	COG2133	pyrroloquinoline quinone binding
BW730_RS16800	COG0534	Mate efflux family protein
BW730_RS16815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BW730_RS16820	COG1704	LemA family
BW730_RS16830	COG2353	YceI-like domain
BW730_RS16845	COG0191	fructose-bisphosphate aldolase activity
BW730_RS16875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW730_RS16895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BW730_RS16900	COG0346	lactoylglutathione lyase activity
BW730_RS16910	COG1070	Carbohydrate kinase
BW730_RS16920	COG0438	transferase activity, transferring glycosyl groups
BW730_RS16930	COG2610	gluconate transmembrane transporter activity
BW730_RS16935	COG3265	gluconokinase activity
BW730_RS16950	COG3458	cephalosporin-C deacetylase activity
BW730_RS16955	COG2186	Transcriptional regulator
BW730_RS16960	COG0747	negative chemotaxis
BW730_RS16970	COG0444	Belongs to the ABC transporter superfamily
BW730_RS16980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BW730_RS16985	COG1940	carbohydrate kinase activity
BW730_RS16990	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BW730_RS17015	COG0166	Belongs to the GPI family
BW730_RS17030	COG0395	ABC-type sugar transport system, permease component
BW730_RS17035	COG1175	transmembrane transport
BW730_RS17055	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BW730_RS17075	COG0018	arginyl-trna synthetase
BW730_RS17080	COG1051	belongs to the nudix hydrolase family
BW730_RS17085	COG1940	carbohydrate kinase activity
BW730_RS17105	COG0205	6-phosphofructokinase activity
BW730_RS17115	COG0277	FAD linked oxidase domain protein
BW730_RS17165	COG0714	Associated with various cellular activities
BW730_RS17175	COG3552	Protein containing von Willebrand factor type A (VWA) domain
BW730_RS17180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BW730_RS17185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BW730_RS17195	COG2326	polyphosphate kinase activity
BW730_RS17200	COG0546	phosphoglycolate phosphatase activity
BW730_RS17220	COG2011	ABC-type metal ion transport system permease component
BW730_RS17225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BW730_RS17260	COG1793	dna ligase
BW730_RS17275	COG1175	transmembrane transport
BW730_RS17280	COG0395	ABC-type sugar transport system, permease component
BW730_RS17285	COG1803	Methylglyoxal synthase
BW730_RS17290	COG1473	amidohydrolase
BW730_RS17305	COG2357	RelA SpoT domain protein
BW730_RS17330	COG1846	Transcriptional regulator
BW730_RS17330	COG1940	carbohydrate kinase activity
BW730_RS17335	COG4447	cellulose binding
BW730_RS17335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BW730_RS17340	COG0395	ABC-type sugar transport system, permease component
BW730_RS17345	COG1175	transmembrane transport
BW730_RS17355	COG0277	FAD linked oxidase domain protein
BW730_RS17360	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BW730_RS17365	COG1088	dTDP-glucose 4,6-dehydratase activity
BW730_RS17375	COG0579	oxidoreductase
BW730_RS17380	COG2095	MarC family integral membrane protein
BW730_RS17410	COG0560	Phosphoserine phosphatase
BW730_RS17410	COG3830	Belongs to the UPF0237 family
BW730_RS17415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BW730_RS17420	COG2813	Specifically methylates the guanine in position
BW730_RS17430	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BW730_RS17435	COG2226	methyltransferase
BW730_RS17455	COG1136	(ABC) transporter
BW730_RS17465	COG2197	response regulator
BW730_RS17495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BW730_RS17500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BW730_RS17505	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
BW730_RS17535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BW730_RS17555	COG0477	Major facilitator Superfamily
BW730_RS17560	COG1228	amidohydrolase
BW730_RS17605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW730_RS17620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW730_RS17665	COG1111	helicase
BW730_RS17665	COG1205	dead DEAH box helicase
BW730_RS17690	COG0667	Aldo Keto reductase
BW730_RS17705	COG1754	DNA topoisomerase type I activity
BW730_RS17705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BW730_RS17715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BW730_RS17720	COG0730	response to heat
BW730_RS17725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BW730_RS17740	COG1774	PSP1 C-terminal conserved region
BW730_RS17795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BW730_RS17800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BW730_RS17805	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BW730_RS17840	COG0302	gtp cyclohydrolase
BW730_RS17850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BW730_RS17870	COG0649	NAD binding
BW730_RS17900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BW730_RS17920	COG3842	ATPase activity