locus-tag	class	description
BW733_RS00020	COG0653	protein targeting
BW733_RS00025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BW733_RS00035	COG5401	PFAM Sporulation and spore germination
BW733_RS00040	COG5002	protein histidine kinase activity
BW733_RS00040	COG5000	phosphorelay sensor kinase activity
BW733_RS00045	COG0745	RESPONSE REGULATOR receiver
BW733_RS00065	COG1678	Uncharacterized ACR, COG1678
BW733_RS00080	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BW733_RS00085	COG0741	lytic transglycosylase activity
BW733_RS00085	COG0739	heme binding
BW733_RS00085	COG1196	nuclear chromosome segregation
BW733_RS00095	COG2884	Cell division ATP-binding protein ftsE
BW733_RS00100	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BW733_RS00120	COG2801	Transposase and inactivated derivatives
BW733_RS00160	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BW733_RS00165	COG0732	type I restriction modification DNA specificity domain
BW733_RS00170	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BW733_RS00180	COG2801	Transposase and inactivated derivatives
BW733_RS00180	COG3415	Transposase
BW733_RS00195	COG0205	6-phosphofructokinase activity
BW733_RS00205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BW733_RS00215	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BW733_RS00215	COG1796	DNA polymerase
BW733_RS00220	COG1648	precorrin-2 dehydrogenase activity
BW733_RS00220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BW733_RS00225	COG1115	amino acid carrier protein
BW733_RS00245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BW733_RS00250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BW733_RS00275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BW733_RS00280	COG2304	oxidoreductase activity
BW733_RS00285	COG2304	oxidoreductase activity
BW733_RS00295	COG0714	Associated with various cellular activities
BW733_RS00365	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BW733_RS00400	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BW733_RS00410	COG0277	FAD linked oxidase domain protein
BW733_RS00430	COG0803	Belongs to the bacterial solute-binding protein 9 family
BW733_RS00435	COG1121	(ABC) transporter
BW733_RS00440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BW733_RS00450	COG1381	Involved in DNA repair and RecF pathway recombination
BW733_RS00455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BW733_RS00465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BW733_RS00475	COG0395	ABC-type sugar transport system, permease component
BW733_RS00480	COG1175	transmembrane transport
BW733_RS00490	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BW733_RS00505	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BW733_RS00525	COG0343	queuine tRNA-ribosyltransferase activity
BW733_RS00535	COG0484	heat shock protein binding
BW733_RS00550	COG2160	L-arabinose isomerase activity
BW733_RS00565	COG1609	Transcriptional regulator
BW733_RS00570	COG0483	inositol monophosphate 1-phosphatase activity
BW733_RS00585	COG1131	(ABC) transporter
BW733_RS00590	COG1725	Transcriptional regulator
BW733_RS00595	COG2723	6-phospho-beta-galactosidase activity
BW733_RS00610	COG1175	transmembrane transport
BW733_RS00615	COG0395	ABC-type sugar transport system, permease component
BW733_RS00620	COG1643	Atp-dependent helicase
BW733_RS00630	COG0481	GTPase activity
BW733_RS00635	COG2801	Transposase and inactivated derivatives
BW733_RS00645	COG0268	Binds directly to 16S ribosomal RNA
BW733_RS00660	COG1191	sigma factor activity
BW733_RS00670	COG0673	inositol 2-dehydrogenase activity
BW733_RS00690	COG1596	polysaccharide export
BW733_RS00690	COG1555	photosystem II stabilization
BW733_RS00695	COG0495	leucyl-tRNA aminoacylation
BW733_RS00700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW733_RS00745	COG0583	DNA-binding transcription factor activity
BW733_RS00750	COG2855	membrane
BW733_RS00765	COG2910	NAD(P)H-binding
BW733_RS00770	COG1733	regulation of RNA biosynthetic process
BW733_RS00785	COG1937	Protein conserved in bacteria
BW733_RS00790	COG0446	pyridine nucleotide-disulphide oxidoreductase
BW733_RS00795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW733_RS00810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BW733_RS00830	COG1484	DNA-dependent DNA replication
BW733_RS00850	COG0582	viral genome integration into host DNA
BW733_RS00855	COG0582	viral genome integration into host DNA
BW733_RS00860	COG4974	Belongs to the 'phage' integrase family
BW733_RS00870	COG0464	growth
BW733_RS00930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BW733_RS00950	COG0667	Aldo Keto reductase
BW733_RS00955	COG3118	belongs to the thioredoxin family
BW733_RS00965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW733_RS00990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BW733_RS00995	COG2871	sodium ion transport
BW733_RS01005	COG0215	cysteine-tRNA ligase activity
BW733_RS01010	COG0215	cysteine-tRNA ligase activity
BW733_RS01020	COG1309	transcriptional regulator
BW733_RS01030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BW733_RS01035	COG4977	sequence-specific DNA binding
BW733_RS01035	COG1917	Cupin 2, conserved barrel domain protein
BW733_RS01075	COG0739	heme binding
BW733_RS01075	COG1196	nuclear chromosome segregation
BW733_RS01075	COG0741	lytic transglycosylase activity
BW733_RS01175	COG0181	hydroxymethylbilane synthase activity
BW733_RS01180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BW733_RS01190	COG0181	hydroxymethylbilane synthase activity
BW733_RS01200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BW733_RS01205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BW733_RS01210	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BW733_RS01215	COG3253	May function as heme-dependent peroxidase
BW733_RS01225	COG0799	negative regulation of ribosome biogenesis
BW733_RS01230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BW733_RS01235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BW733_RS01245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BW733_RS01250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BW733_RS01255	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BW733_RS01260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BW733_RS01265	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BW733_RS01275	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BW733_RS01280	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW733_RS01295	COG1648	precorrin-2 dehydrogenase activity
BW733_RS01295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BW733_RS01300	COG1797	cobyrinic acid a,c-diamide synthase activity
BW733_RS01330	COG0310	cobalt ion transport
BW733_RS01340	COG1648	precorrin-2 dehydrogenase activity
BW733_RS01340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BW733_RS01355	COG1492	cobalamin metabolic process
BW733_RS01360	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BW733_RS01375	COG1185	polyribonucleotide nucleotidyltransferase activity
BW733_RS01380	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BW733_RS01380	COG0506	proline dehydrogenase activity
BW733_RS01380	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BW733_RS01385	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BW733_RS01400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BW733_RS01405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BW733_RS01410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BW733_RS01435	COG0779	Required for maturation of 30S ribosomal subunits
BW733_RS01450	COG0442	prolyl-tRNA aminoacylation
BW733_RS01460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BW733_RS01465	COG0750	zinc metalloprotease
BW733_RS01470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BW733_RS01485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BW733_RS01505	COG2226	methyltransferase
BW733_RS01510	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BW733_RS01510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BW733_RS01530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BW733_RS01540	COG0233	cytoplasmic translational termination
BW733_RS01545	COG0528	UMP kinase activity
BW733_RS01550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BW733_RS01555	COG0052	Belongs to the universal ribosomal protein uS2 family
BW733_RS01560	COG1388	LysM domain
BW733_RS01560	COG4942	peptidase
BW733_RS01565	COG4974	Belongs to the 'phage' integrase family
BW733_RS01570	COG0242	peptide deformylase activity
BW733_RS01590	COG1737	Transcriptional regulator
BW733_RS01595	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BW733_RS01630	COG1119	ATPase activity
BW733_RS01635	COG0656	L-ascorbic acid biosynthetic process
BW733_RS01645	COG1028	Short-chain dehydrogenase reductase Sdr
BW733_RS01665	COG2226	methyltransferase
BW733_RS01670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BW733_RS01675	COG2190	(PTS) system
BW733_RS01675	COG2211	Major facilitator Superfamily
BW733_RS01680	COG0366	Alpha amylase catalytic
BW733_RS01685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW733_RS01690	COG0488	(ABC) transporter
BW733_RS01695	COG2197	response regulator
BW733_RS01700	COG2801	Transposase and inactivated derivatives
BW733_RS01700	COG3415	Transposase
BW733_RS01715	COG2267	carboxylic ester hydrolase activity
BW733_RS01730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BW733_RS01735	COG0396	ATPase activity
BW733_RS01760	COG1131	(ABC) transporter
BW733_RS01790	COG2814	Major facilitator Superfamily
BW733_RS01805	COG1136	(ABC) transporter
BW733_RS01825	COG3344	reverse transcriptase
BW733_RS01860	COG0109	protoheme IX farnesyltransferase activity
BW733_RS01875	COG0363	glucosamine-6-phosphate deaminase activity
BW733_RS01890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BW733_RS01895	COG0149	triose-phosphate isomerase activity
BW733_RS01900	COG0126	phosphoglycerate kinase activity
BW733_RS01905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BW733_RS01910	COG1481	regulation of sporulation
BW733_RS01920	COG1660	Displays ATPase and GTPase activities
BW733_RS01935	COG1122	ATPase activity
BW733_RS01940	COG0322	excinuclease ABC activity
BW733_RS01950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BW733_RS01970	COG0556	nucleotide-excision repair
BW733_RS01985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BW733_RS01990	COG0509	glycine decarboxylation via glycine cleavage system
BW733_RS01995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BW733_RS01995	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BW733_RS02000	COG0477	Major facilitator Superfamily
BW733_RS02010	COG0237	dephospho-CoA kinase activity
BW733_RS02015	COG0539	negative regulation of cytoplasmic translation
BW733_RS02020	COG2801	Transposase and inactivated derivatives
BW733_RS02035	COG2050	protein possibly involved in aromatic compounds catabolism
BW733_RS02050	COG0469	pyruvate kinase activity
BW733_RS02060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BW733_RS02075	COG1799	cell septum assembly
BW733_RS02090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BW733_RS02095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BW733_RS02100	COG0772	Belongs to the SEDS family
BW733_RS02105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BW733_RS02110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BW733_RS02115	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BW733_RS02125	COG0768	penicillin binding
BW733_RS02135	COG0275	rRNA processing
BW733_RS02140	COG2001	Belongs to the MraZ family
BW733_RS02145	COG0714	Associated with various cellular activities
BW733_RS02180	COG0587	DNA-directed DNA polymerase activity
BW733_RS02215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BW733_RS02215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BW733_RS02220	COG3973	AAA domain
BW733_RS02230	COG0142	geranyltranstransferase activity
BW733_RS02235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BW733_RS02245	COG2815	serine threonine protein kinase
BW733_RS02245	COG0515	serine threonine protein kinase
BW733_RS02260	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BW733_RS02265	COG2197	response regulator
BW733_RS02300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BW733_RS02310	COG0088	Forms part of the polypeptide exit tunnel
BW733_RS02315	COG3214	Protein conserved in bacteria
BW733_RS02325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BW733_RS02335	COG1845	cytochrome c oxidase, subunit III
BW733_RS02340	COG2010	Cytochrome c
BW733_RS02345	COG0723	plastoquinol--plastocyanin reductase activity
BW733_RS02350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BW733_RS02355	COG3831	ATPase activity
BW733_RS02360	COG0714	Associated with various cellular activities
BW733_RS02385	COG4585	Histidine kinase
BW733_RS02390	COG2197	response regulator
BW733_RS02395	COG4152	abc transporter atp-binding protein
BW733_RS02410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BW733_RS02415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BW733_RS02455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BW733_RS02475	COG2801	Transposase and inactivated derivatives
BW733_RS02480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW733_RS02485	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW733_RS02490	COG1811	Na channel or pump
BW733_RS02495	COG0321	lipoyl(octanoyl) transferase activity
BW733_RS02500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BW733_RS02510	COG0488	(ABC) transporter
BW733_RS02515	COG2066	Belongs to the glutaminase family
BW733_RS02525	COG0656	L-ascorbic acid biosynthetic process
BW733_RS02540	COG1823	symporter activity
BW733_RS02545	COG0174	glutamine synthetase
BW733_RS02550	COG2409	Drug exporters of the RND superfamily
BW733_RS02555	COG0604	alcohol dehydrogenase
BW733_RS02575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BW733_RS02580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BW733_RS02585	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BW733_RS02595	COG0174	glutamine synthetase
BW733_RS02640	COG2801	Transposase and inactivated derivatives
BW733_RS02690	COG0557	exoribonuclease II activity
BW733_RS02700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW733_RS02705	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BW733_RS02710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BW733_RS02730	COG3304	Inner membrane component domain
BW733_RS02735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BW733_RS02740	COG0101	tRNA pseudouridine synthase activity
BW733_RS02760	COG2755	lipolytic protein G-D-S-L family
BW733_RS02760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BW733_RS02765	COG0438	transferase activity, transferring glycosyl groups
BW733_RS02780	COG1609	Transcriptional regulator
BW733_RS02790	COG4120	Belongs to the binding-protein-dependent transport system permease family
BW733_RS02805	COG0203	ribosomal protein L17
BW733_RS02810	COG0202	RNA polymerase activity
BW733_RS02815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BW733_RS02820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BW733_RS02825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BW733_RS02830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BW733_RS02840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BW733_RS02850	COG2801	Transposase and inactivated derivatives
BW733_RS02860	COG3459	Glycosyltransferase 36 associated
BW733_RS02875	COG1175	transmembrane transport
BW733_RS02880	COG0395	ABC-type sugar transport system, permease component
BW733_RS02910	COG0024	Methionine aminopeptidase
BW733_RS02915	COG0563	adenylate kinase activity
BW733_RS02930	COG1841	ribosomal large subunit assembly
BW733_RS02935	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BW733_RS02940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BW733_RS02945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BW733_RS02950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BW733_RS02955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BW733_RS02960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BW733_RS02965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BW733_RS02970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BW733_RS02980	COG1950	PFAM Membrane protein of
BW733_RS02990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BW733_RS02995	COG0255	Belongs to the universal ribosomal protein uL29 family
BW733_RS03000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BW733_RS03005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BW733_RS03010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BW733_RS03015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BW733_RS03020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BW733_RS03025	COG0089	rRNA binding
BW733_RS03030	COG0088	Forms part of the polypeptide exit tunnel
BW733_RS03035	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BW733_RS03040	COG0051	transcription antitermination factor activity, RNA binding
BW733_RS03050	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BW733_RS03085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BW733_RS03095	COG1051	belongs to the nudix hydrolase family
BW733_RS03120	COG0435	Glutathione S-transferase
BW733_RS03135	COG2837	iron assimilation
BW733_RS03140	COG0281	malic enzyme
BW733_RS03150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BW733_RS03160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BW733_RS03185	COG1879	ABC-type sugar transport system periplasmic component
BW733_RS03190	COG0395	ABC-type sugar transport system, permease component
BW733_RS03225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BW733_RS03230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BW733_RS03235	COG0049	tRNA binding
BW733_RS03240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BW733_RS03250	COG2801	Transposase and inactivated derivatives
BW733_RS03265	COG4974	Belongs to the 'phage' integrase family
BW733_RS03285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BW733_RS03290	COG0085	RNA polymerase activity
BW733_RS03295	COG0222	ribosome binding
BW733_RS03300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BW733_RS03305	COG2801	Transposase and inactivated derivatives
BW733_RS03315	COG0765	amino acid transport
BW733_RS03330	COG1609	Transcriptional regulator
BW733_RS03340	COG0081	regulation of translation
BW733_RS03345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BW733_RS03350	COG0250	Participates in transcription elongation, termination and antitermination
BW733_RS03370	COG1132	(ABC) transporter
BW733_RS03375	COG1132	(ABC) transporter
BW733_RS03380	COG1473	amidohydrolase
BW733_RS03385	COG1705	Flagellar rod assembly protein muramidase FlgJ
BW733_RS03385	COG3942	CHAP domain
BW733_RS03390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BW733_RS03400	COG2030	dehydratase
BW733_RS03410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BW733_RS03430	COG2801	Transposase and inactivated derivatives
BW733_RS03440	COG0813	purine-nucleoside phosphorylase activity
BW733_RS03450	COG1666	GTP binding
BW733_RS03455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BW733_RS03475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW733_RS03485	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW733_RS03490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BW733_RS03495	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BW733_RS03495	COG0674	pyruvate-flavodoxin oxidoreductase activity
BW733_RS03500	COG1013	pyruvate-flavodoxin oxidoreductase activity
BW733_RS03510	COG3590	peptidase
BW733_RS03520	COG0142	geranyltranstransferase activity
BW733_RS03525	COG1007	ATP synthesis coupled electron transport
BW733_RS03550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW733_RS03555	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BW733_RS03560	COG1034	ATP synthesis coupled electron transport
BW733_RS03565	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BW733_RS03575	COG0649	NAD binding
BW733_RS03580	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW733_RS03585	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW733_RS03595	COG0644	oxidoreductase
BW733_RS03600	COG1169	isochorismate synthase
BW733_RS03610	COG0542	response to heat
BW733_RS03615	COG0542	response to heat
BW733_RS03625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BW733_RS03630	COG0484	heat shock protein binding
BW733_RS03645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BW733_RS03650	COG2226	methyltransferase
BW733_RS03660	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BW733_RS03665	COG4948	Mandelate Racemase Muconate Lactonizing
BW733_RS03685	COG1461	Dihydroxyacetone kinase
BW733_RS03690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BW733_RS03715	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BW733_RS03735	COG0544	peptidyl-prolyl cis-trans isomerase activity
BW733_RS03745	COG1082	Xylose isomerase domain protein TIM barrel
BW733_RS03760	COG1129	ABC transporter
BW733_RS03765	COG1879	ABC-type sugar transport system periplasmic component
BW733_RS03770	COG1349	DNA-binding transcription factor activity
BW733_RS03785	COG2066	Belongs to the glutaminase family
BW733_RS03785	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BW733_RS03795	COG1070	Carbohydrate kinase
BW733_RS03800	COG1609	Transcriptional regulator
BW733_RS03840	COG1794	racemase activity, acting on amino acids and derivatives
BW733_RS03860	COG3040	lipid binding
BW733_RS03930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW733_RS03960	COG2838	Isocitrate dehydrogenase
BW733_RS03980	COG0442	prolyl-tRNA aminoacylation
BW733_RS03985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BW733_RS04005	COG0577	efflux transmembrane transporter activity
BW733_RS04005	COG1136	(ABC) transporter
BW733_RS04010	COG1136	(ABC) transporter
BW733_RS04010	COG0577	efflux transmembrane transporter activity
BW733_RS04025	COG1757	Na H antiporter
BW733_RS04030	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BW733_RS04060	COG0521	Mo-molybdopterin cofactor biosynthetic process
BW733_RS04060	COG0315	cyclic pyranopterin monophosphate synthase activity
BW733_RS04065	COG0315	cyclic pyranopterin monophosphate synthase activity
BW733_RS04070	COG0303	'Molybdopterin
BW733_RS04080	COG0314	molybdopterin synthase activity
BW733_RS04100	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BW733_RS04105	COG1140	nitrate reductase beta subunit
BW733_RS04115	COG0746	molybdenum cofactor guanylyltransferase activity
BW733_RS04125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BW733_RS04135	COG3833	ABC-type maltose transport systems, permease component
BW733_RS04140	COG1175	transmembrane transport
BW733_RS04150	COG1609	Transcriptional regulator
BW733_RS04155	COG1126	abc transporter atp-binding protein
BW733_RS04160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW733_RS04165	COG0765	amino acid transport
BW733_RS04170	COG0765	amino acid transport
BW733_RS04175	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BW733_RS04180	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BW733_RS04205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BW733_RS04215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BW733_RS04230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BW733_RS04240	COG1846	Transcriptional regulator
BW733_RS04245	COG0697	spore germination
BW733_RS04285	COG0151	Belongs to the GarS family
BW733_RS04310	COG2318	DinB family
BW733_RS04315	COG3415	Transposase
BW733_RS04315	COG2801	Transposase and inactivated derivatives
BW733_RS04325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BW733_RS04350	COG2376	Dihydroxyacetone kinase
BW733_RS04355	COG1461	Dihydroxyacetone kinase
BW733_RS04390	COG1175	transmembrane transport
BW733_RS04395	COG1653	transport
BW733_RS04400	COG1609	Transcriptional regulator
BW733_RS04410	COG1217	gtp-binding protein TYPA
BW733_RS04435	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BW733_RS04445	COG3485	protocatechuate 3,4-dioxygenase
BW733_RS04450	COG1490	D-aminoacyl-tRNA deacylase activity
BW733_RS04460	COG0745	RESPONSE REGULATOR receiver
BW733_RS04465	COG0456	acetyltransferase
BW733_RS04470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BW733_RS04475	COG0406	alpha-ribazole phosphatase activity
BW733_RS04475	COG0494	nUDIX hydrolase
BW733_RS04495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BW733_RS04505	COG1028	Short-chain dehydrogenase reductase Sdr
BW733_RS04515	COG1472	Belongs to the glycosyl hydrolase 3 family
BW733_RS04525	COG0300	oxidoreductase activity
BW733_RS04535	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BW733_RS04545	COG0785	Cytochrome C biogenesis protein
BW733_RS04555	COG0406	alpha-ribazole phosphatase activity
BW733_RS04575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BW733_RS04595	COG1082	Xylose isomerase domain protein TIM barrel
BW733_RS04605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BW733_RS04620	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BW733_RS04625	COG4143	(ABC) transporter
BW733_RS04635	COG3842	ATPase activity
BW733_RS04640	COG0477	Major facilitator Superfamily
BW733_RS04655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BW733_RS04660	COG2149	membrane
BW733_RS04680	COG0649	NAD binding
BW733_RS04700	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BW733_RS04710	COG0302	gtp cyclohydrolase
BW733_RS04730	COG0037	tRNA processing
BW733_RS04740	COG2027	D-alanyl-D-alanine carboxypeptidase
BW733_RS04745	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BW733_RS04750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BW733_RS04755	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BW733_RS04805	COG1774	PSP1 C-terminal conserved region
BW733_RS04815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BW733_RS04820	COG0730	response to heat
BW733_RS04825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BW733_RS04835	COG1754	DNA topoisomerase type I activity
BW733_RS04835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BW733_RS04855	COG1695	Transcriptional regulator
BW733_RS04860	COG3214	Protein conserved in bacteria
BW733_RS04875	COG0667	Aldo Keto reductase
BW733_RS04895	COG1111	helicase
BW733_RS04895	COG1205	dead DEAH box helicase
BW733_RS04940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW733_RS04945	COG0494	nUDIX hydrolase
BW733_RS04955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW733_RS05010	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BW733_RS05025	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BW733_RS05060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BW733_RS05065	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
BW733_RS05070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BW733_RS05075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BW733_RS05100	COG2801	Transposase and inactivated derivatives
BW733_RS05135	COG4974	Belongs to the 'phage' integrase family
BW733_RS05140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BW733_RS05170	COG0791	NLP P60 protein
BW733_RS05170	COG3883	PFAM NLP P60 protein
BW733_RS05235	COG3344	reverse transcriptase
BW733_RS05250	COG4974	Belongs to the 'phage' integrase family
BW733_RS05255	COG0582	viral genome integration into host DNA
BW733_RS05260	COG0582	viral genome integration into host DNA
BW733_RS05305	COG2197	response regulator
BW733_RS05315	COG1136	(ABC) transporter
BW733_RS05350	COG1349	DNA-binding transcription factor activity
BW733_RS05365	COG2813	Specifically methylates the guanine in position
BW733_RS05380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BW733_RS05385	COG0560	Phosphoserine phosphatase
BW733_RS05390	COG0406	alpha-ribazole phosphatase activity
BW733_RS05400	COG2095	MarC family integral membrane protein
BW733_RS05410	COG0277	FAD linked oxidase domain protein
BW733_RS05435	COG2357	RelA SpoT domain protein
BW733_RS05450	COG3655	Transcriptional regulator
BW733_RS05460	COG1473	amidohydrolase
BW733_RS05465	COG1803	Methylglyoxal synthase
BW733_RS05485	COG0693	protein deglycase activity
BW733_RS05510	COG1285	pathogenesis
BW733_RS05515	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BW733_RS05520	COG0351	phosphomethylpyrimidine kinase
BW733_RS05520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BW733_RS05520	COG0352	thiamine-phosphate diphosphorylase activity
BW733_RS05525	COG0351	phosphomethylpyrimidine kinase
BW733_RS05530	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BW733_RS05530	COG0352	thiamine-phosphate diphosphorylase activity
BW733_RS05530	COG0351	phosphomethylpyrimidine kinase
BW733_RS05540	COG0058	SHG alpha-glucan phosphorylase activity
BW733_RS05580	COG0789	Transcriptional regulator
BW733_RS05585	COG0484	heat shock protein binding
BW733_RS05590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BW733_RS05610	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BW733_RS05630	COG1252	NADH dehydrogenase
BW733_RS05640	COG0745	RESPONSE REGULATOR receiver
BW733_RS05645	COG2205	protein histidine kinase activity
BW733_RS05655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BW733_RS05660	COG1132	(ABC) transporter
BW733_RS05665	COG0717	Belongs to the dCTP deaminase family
BW733_RS05685	COG0714	Associated with various cellular activities
BW733_RS05700	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BW733_RS05710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BW733_RS05740	COG3132	Protein of unknown function, DUF480
BW733_RS05750	COG1653	transport
BW733_RS05755	COG0433	COG0433 Predicted ATPase
BW733_RS05780	COG2801	Transposase and inactivated derivatives
BW733_RS05790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BW733_RS05805	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BW733_RS05820	COG1129	ABC transporter
BW733_RS05885	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BW733_RS05890	COG0584	glycerophosphoryl diester phosphodiesterase
BW733_RS05900	COG2801	Transposase and inactivated derivatives
BW733_RS05905	COG2801	Transposase and inactivated derivatives
BW733_RS05930	COG1201	RNA secondary structure unwinding
BW733_RS05935	COG3415	Transposase
BW733_RS05935	COG2801	Transposase and inactivated derivatives
BW733_RS05985	COG1175	transmembrane transport
BW733_RS05990	COG0395	ABC-type sugar transport system, permease component
BW733_RS06000	COG0383	alpha-mannosidase activity
BW733_RS06015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BW733_RS06035	COG1316	TRANSCRIPTIONal
BW733_RS06050	COG0564	pseudouridine synthase activity
BW733_RS06095	COG1131	(ABC) transporter
BW733_RS06100	COG0842	Transport permease protein
BW733_RS06105	COG4585	Histidine kinase
BW733_RS06110	COG2197	response regulator
BW733_RS06115	COG0477	Major facilitator Superfamily
BW733_RS06175	COG0137	argininosuccinate synthase activity
BW733_RS06235	COG0438	transferase activity, transferring glycosyl groups
BW733_RS06240	COG0438	transferase activity, transferring glycosyl groups
BW733_RS06250	COG0438	transferase activity, transferring glycosyl groups
BW733_RS06265	COG1134	teichoic acid transport
BW733_RS06275	COG0561	phosphatase activity
BW733_RS06280	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BW733_RS06285	COG2814	Major facilitator Superfamily
BW733_RS06295	COG1597	lipid kinase activity
BW733_RS06310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BW733_RS06315	COG0582	viral genome integration into host DNA
BW733_RS06325	COG4974	Belongs to the 'phage' integrase family
BW733_RS06335	COG3344	reverse transcriptase
BW733_RS06350	COG1404	Belongs to the peptidase S8 family
BW733_RS06355	COG1674	ftsk spoiiie
BW733_RS06400	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BW733_RS06405	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BW733_RS06415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BW733_RS06425	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW733_RS06430	COG0022	dehydrogenase e1 component
BW733_RS06440	COG0737	Belongs to the 5'-nucleotidase family
BW733_RS06445	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BW733_RS06450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BW733_RS06485	COG1595	DNA-templated transcription, initiation
BW733_RS06525	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BW733_RS06530	COG2124	cytochrome p450
BW733_RS06545	COG0517	IMP dehydrogenase activity
BW733_RS06585	COG2390	Transcriptional regulator
BW733_RS06590	COG1064	alcohol dehydrogenase
BW733_RS06600	COG1309	transcriptional regulator
BW733_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
BW733_RS06640	COG0028	Belongs to the TPP enzyme family
BW733_RS06645	COG0640	Transcriptional regulator
BW733_RS06655	COG2329	Antibiotic biosynthesis monooxygenase
BW733_RS06660	COG1846	Transcriptional regulator
BW733_RS06670	COG1760	l-serine dehydratase
BW733_RS06675	COG2197	response regulator
BW733_RS06700	COG1090	epimerase
BW733_RS06705	COG0501	Belongs to the peptidase M48B family
BW733_RS06710	COG0359	binds to the 23S rRNA
BW733_RS06715	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BW733_RS06725	COG0360	Binds together with S18 to 16S ribosomal RNA
BW733_RS06750	COG1022	Amp-dependent synthetase and ligase
BW733_RS06755	COG0488	(ABC) transporter
BW733_RS06760	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BW733_RS06780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BW733_RS06785	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BW733_RS06790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BW733_RS06790	COG2111	Na H antiporter
BW733_RS06795	COG1006	Multisubunit Na H antiporter MnhC subunit
BW733_RS06800	COG0651	ATP synthesis coupled electron transport
BW733_RS06805	COG1863	multisubunit Na H antiporter MnhE subunit
BW733_RS06815	COG1320	monovalent cation:proton antiporter activity
BW733_RS06820	COG2154	pterin-4-alpha-carbinolamine dehydratase
BW733_RS06850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW733_RS06875	COG4221	oxidoreductase activity
BW733_RS06910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BW733_RS06910	COG0574	Belongs to the PEP-utilizing enzyme family
BW733_RS06915	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BW733_RS06960	COG4214	carbohydrate transport
BW733_RS06975	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BW733_RS07005	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BW733_RS07010	COG2318	DinB family
BW733_RS07025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW733_RS07035	COG1733	regulation of RNA biosynthetic process
BW733_RS07040	COG0668	transmembrane transport
BW733_RS07045	COG0617	tRNA 3'-terminal CCA addition
BW733_RS07055	COG2815	serine threonine protein kinase
BW733_RS07055	COG0515	serine threonine protein kinase
BW733_RS07065	COG0477	Major facilitator Superfamily
BW733_RS07090	COG2822	iron ion transport
BW733_RS07095	COG0672	)-iron permease
BW733_RS07125	COG1793	dna ligase
BW733_RS07140	COG1129	ABC transporter
BW733_RS07150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BW733_RS07155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BW733_RS07235	COG2409	Drug exporters of the RND superfamily
BW733_RS07255	COG3851	Histidine kinase
BW733_RS07260	COG2197	response regulator
BW733_RS07295	COG1131	(ABC) transporter
BW733_RS07300	COG0842	Transport permease protein
BW733_RS07315	COG2076	Multidrug Resistance protein
BW733_RS07325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW733_RS07355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BW733_RS07375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BW733_RS07380	COG2354	Protein conserved in bacteria
BW733_RS07435	COG1518	maintenance of DNA repeat elements
BW733_RS07480	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BW733_RS07540	COG2801	Transposase and inactivated derivatives
BW733_RS07560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BW733_RS07590	COG0741	lytic transglycosylase activity
BW733_RS07590	COG0739	heme binding
BW733_RS07590	COG1196	nuclear chromosome segregation
BW733_RS07600	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
BW733_RS07605	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BW733_RS07610	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BW733_RS07615	COG0592	DNA-directed DNA polymerase activity
BW733_RS07625	COG1136	(ABC) transporter
BW733_RS07660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BW733_RS07665	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BW733_RS07670	COG0594	ribonuclease P activity
BW733_RS07675	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BW733_RS07680	COG0706	membrane insertase activity
BW733_RS07690	COG0357	Ribosomal RNA small subunit methyltransferase G
BW733_RS07695	COG1733	regulation of RNA biosynthetic process
BW733_RS07700	COG1484	DNA-dependent DNA replication
BW733_RS07730	COG1475	DNA binding
BW733_RS07745	COG1181	Belongs to the D-alanine--D-alanine ligase family
BW733_RS07760	COG3118	belongs to the thioredoxin family
BW733_RS07765	COG0492	ferredoxin-NADP+ reductase activity
BW733_RS07770	COG1024	Enoyl-CoA hydratase
BW733_RS07780	COG2390	Transcriptional regulator
BW733_RS07785	COG1335	isochorismatase
BW733_RS07795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BW733_RS07910	COG2801	Transposase and inactivated derivatives
BW733_RS07910	COG3415	Transposase
BW733_RS07920	COG3328	transposase activity
BW733_RS07930	COG3119	arylsulfatase activity
BW733_RS07940	COG0395	ABC-type sugar transport system, permease component
BW733_RS07945	COG4209	transmembrane transport
BW733_RS07955	COG3119	arylsulfatase activity
BW733_RS07960	COG5434	Belongs to the glycosyl hydrolase 28 family
BW733_RS07975	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BW733_RS07985	COG0673	inositol 2-dehydrogenase activity
BW733_RS08000	COG4974	Belongs to the 'phage' integrase family
BW733_RS08005	COG2801	Transposase and inactivated derivatives
BW733_RS08020	COG4974	Belongs to the 'phage' integrase family
BW733_RS08030	COG3328	transposase activity
BW733_RS08090	COG4585	Histidine kinase
BW733_RS08180	COG0673	inositol 2-dehydrogenase activity
BW733_RS08185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BW733_RS08190	COG2188	Transcriptional regulator
BW733_RS08205	COG3718	enzyme involved in inositol metabolism
BW733_RS08210	COG3962	Belongs to the TPP enzyme family
BW733_RS08215	COG1082	Xylose isomerase domain protein TIM barrel
BW733_RS08220	COG1879	ABC-type sugar transport system periplasmic component
BW733_RS08225	COG1129	ABC transporter
BW733_RS08230	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW733_RS08235	COG0673	inositol 2-dehydrogenase activity
BW733_RS08240	COG1082	Xylose isomerase domain protein TIM barrel
BW733_RS08245	COG0673	inositol 2-dehydrogenase activity
BW733_RS08270	COG4585	Histidine kinase
BW733_RS08275	COG2197	response regulator
BW733_RS08300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BW733_RS08310	COG1940	carbohydrate kinase activity
BW733_RS08315	COG2115	Belongs to the xylose isomerase family
BW733_RS08330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BW733_RS08420	COG0457	Tetratricopeptide repeat
BW733_RS08420	COG0705	Rhomboid family
BW733_RS08510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BW733_RS08520	COG0640	Transcriptional regulator
BW733_RS08535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BW733_RS08540	COG4974	Belongs to the 'phage' integrase family
BW733_RS08545	COG0582	viral genome integration into host DNA
BW733_RS08550	COG0582	viral genome integration into host DNA
BW733_RS08565	COG1132	(ABC) transporter
BW733_RS08605	COG1660	Displays ATPase and GTPase activities
BW733_RS08650	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BW733_RS08670	COG0456	acetyltransferase
BW733_RS08675	COG1278	Cold shock
BW733_RS08685	COG4106	trans-aconitate 2-methyltransferase activity
BW733_RS08720	COG0657	acetylesterase activity
BW733_RS08730	COG1764	response to oxidative stress
BW733_RS08740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BW733_RS08745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BW733_RS08755	COG0419	ATPase involved in DNA repair
BW733_RS08760	COG0420	3'-5' exonuclease activity
BW733_RS08775	COG2197	response regulator
BW733_RS08780	COG2340	Cysteine-rich secretory protein family
BW733_RS08840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW733_RS08855	COG4172	Belongs to the ABC transporter superfamily
BW733_RS08885	COG4941	Belongs to the sigma-70 factor family
BW733_RS08905	COG0513	Belongs to the DEAD box helicase family
BW733_RS08915	COG0823	Involved in the tonB-independent uptake of proteins
BW733_RS08915	COG1506	peptidase
BW733_RS08945	COG4941	Belongs to the sigma-70 factor family
BW733_RS08950	COG2801	Transposase and inactivated derivatives
BW733_RS08970	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BW733_RS08995	COG3655	Transcriptional regulator
BW733_RS09015	COG4221	oxidoreductase activity
BW733_RS09015	COG3321	synthase
BW733_RS09015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BW733_RS09015	COG0604	alcohol dehydrogenase
BW733_RS09070	COG1609	Transcriptional regulator
BW733_RS09145	COG1064	alcohol dehydrogenase
BW733_RS09155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BW733_RS09160	COG1253	flavin adenine dinucleotide binding
BW733_RS09175	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BW733_RS09190	COG0318	PFAM AMP-dependent synthetase and ligase
BW733_RS09200	COG2267	carboxylic ester hydrolase activity
BW733_RS09205	COG4214	carbohydrate transport
BW733_RS09245	COG1132	(ABC) transporter
BW733_RS09275	COG0439	Biotin carboxylase
BW733_RS09280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BW733_RS09300	COG2205	protein histidine kinase activity
BW733_RS09305	COG0745	RESPONSE REGULATOR receiver
BW733_RS09370	COG1012	belongs to the aldehyde dehydrogenase family
BW733_RS09425	COG4608	Belongs to the ABC transporter superfamily
BW733_RS09455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW733_RS09465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW733_RS09475	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW733_RS09510	COG1597	lipid kinase activity
BW733_RS09560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW733_RS09565	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW733_RS09570	COG1120	ATPase activity
BW733_RS09580	COG1393	Belongs to the ArsC family
BW733_RS09595	COG0686	Belongs to the AlaDH PNT family
BW733_RS09600	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BW733_RS09605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW733_RS09610	COG1397	ADP-ribosylglycohydrolase
BW733_RS09630	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BW733_RS09640	COG1742	UPF0060 membrane protein
BW733_RS09655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BW733_RS09660	COG1309	transcriptional regulator
BW733_RS09685	COG0305	Participates in initiation and elongation during chromosome replication
BW733_RS09690	COG1937	Protein conserved in bacteria
BW733_RS09700	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BW733_RS09705	COG0114	fumarate hydratase activity
BW733_RS09735	COG1929	Belongs to the glycerate kinase type-1 family
BW733_RS09740	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BW733_RS09745	COG4988	ABC transporter
BW733_RS09750	COG1294	oxidase, subunit
BW733_RS09755	COG1271	oxidase subunit
BW733_RS09765	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BW733_RS09770	COG2326	polyphosphate kinase activity
BW733_RS09775	COG2514	catechol 2,3-dioxygenase activity
BW733_RS09810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BW733_RS09820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BW733_RS09840	COG0515	serine threonine protein kinase
BW733_RS09845	COG0768	penicillin binding
BW733_RS09865	COG1716	ATPase activity
BW733_RS09875	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BW733_RS09880	COG1609	Transcriptional regulator
BW733_RS09915	COG3344	reverse transcriptase
BW733_RS09925	COG4974	Belongs to the 'phage' integrase family
BW733_RS09940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BW733_RS09955	COG1070	Carbohydrate kinase
BW733_RS09960	COG0406	alpha-ribazole phosphatase activity
BW733_RS09965	COG0438	transferase activity, transferring glycosyl groups
BW733_RS09975	COG2610	gluconate transmembrane transporter activity
BW733_RS09980	COG3265	gluconokinase activity
BW733_RS10000	COG3458	cephalosporin-C deacetylase activity
BW733_RS10005	COG2186	Transcriptional regulator
BW733_RS10010	COG0747	negative chemotaxis
BW733_RS10020	COG0444	Belongs to the ABC transporter superfamily
BW733_RS10030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BW733_RS10040	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BW733_RS10065	COG0166	Belongs to the GPI family
BW733_RS10075	COG2226	methyltransferase
BW733_RS10095	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BW733_RS10115	COG0018	arginyl-trna synthetase
BW733_RS10120	COG1940	carbohydrate kinase activity
BW733_RS10140	COG0205	6-phosphofructokinase activity
BW733_RS10160	COG0277	FAD linked oxidase domain protein
BW733_RS10210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BW733_RS10220	COG2326	polyphosphate kinase activity
BW733_RS10225	COG0546	phosphoglycolate phosphatase activity
BW733_RS10235	COG1464	Belongs to the NlpA lipoprotein family
BW733_RS10240	COG2011	ABC-type metal ion transport system permease component
BW733_RS10245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BW733_RS10250	COG2267	carboxylic ester hydrolase activity
BW733_RS10295	COG1793	dna ligase
BW733_RS10310	COG0156	8-amino-7-oxononanoate synthase activity
BW733_RS10315	COG1063	alcohol dehydrogenase
BW733_RS10325	COG1472	Belongs to the glycosyl hydrolase 3 family
BW733_RS10335	COG0542	response to heat
BW733_RS10350	COG0259	pyridoxamine-phosphate oxidase activity
BW733_RS10365	COG2133	pyrroloquinoline quinone binding
BW733_RS10370	COG0534	Mate efflux family protein
BW733_RS10375	COG2095	MarC family integral membrane protein
BW733_RS10395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BW733_RS10400	COG1704	LemA family
BW733_RS10420	COG0191	fructose-bisphosphate aldolase activity
BW733_RS10445	COG1937	Protein conserved in bacteria
BW733_RS10450	COG2217	Heavy metal translocating P-type atpase
BW733_RS10485	COG2205	protein histidine kinase activity
BW733_RS10490	COG0745	RESPONSE REGULATOR receiver
BW733_RS10535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW733_RS10545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BW733_RS10605	COG1404	Belongs to the peptidase S8 family
BW733_RS10635	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW733_RS10650	COG1070	Carbohydrate kinase
BW733_RS10655	COG1609	Transcriptional regulator
BW733_RS10665	COG4213	ABC transporter substrate-binding protein
BW733_RS10670	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW733_RS10675	COG1129	ABC transporter
BW733_RS10685	COG1129	ABC transporter
BW733_RS10690	COG1879	ABC-type sugar transport system periplasmic component
BW733_RS10695	COG1595	DNA-templated transcription, initiation
BW733_RS10715	COG1595	DNA-templated transcription, initiation
BW733_RS10750	COG1349	DNA-binding transcription factor activity
BW733_RS10755	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW733_RS10760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW733_RS10765	COG0022	dehydrogenase e1 component
BW733_RS10775	COG1028	Short-chain dehydrogenase reductase Sdr
BW733_RS10780	COG2190	(PTS) system
BW733_RS10780	COG1263	PTS System
BW733_RS10780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW733_RS10790	COG0494	nUDIX hydrolase
BW733_RS10825	COG0582	viral genome integration into host DNA
BW733_RS10835	COG2801	Transposase and inactivated derivatives
BW733_RS10845	COG4974	Belongs to the 'phage' integrase family
BW733_RS10850	COG0582	viral genome integration into host DNA
BW733_RS10855	COG4974	Belongs to the 'phage' integrase family
BW733_RS10885	COG4974	Belongs to the 'phage' integrase family
BW733_RS10890	COG0582	viral genome integration into host DNA
BW733_RS10895	COG0582	viral genome integration into host DNA
BW733_RS10905	COG3328	transposase activity
BW733_RS10945	COG0588	phosphoglycerate mutase activity
BW733_RS10960	COG5002	protein histidine kinase activity
BW733_RS10975	COG1329	Transcriptional regulator
BW733_RS10980	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BW733_RS10985	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BW733_RS10995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BW733_RS11005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BW733_RS11010	COG0215	cysteine-tRNA ligase activity
BW733_RS11030	COG0789	Transcriptional regulator
BW733_RS11050	COG0626	cystathionine gamma-synthase activity
BW733_RS11055	COG3842	ATPase activity
BW733_RS11135	COG4133	protoheme IX ABC transporter activity
BW733_RS11180	COG0494	nUDIX hydrolase
BW733_RS11190	COG0363	glucosamine-6-phosphate deaminase activity
BW733_RS11195	COG1278	Cold shock
BW733_RS11210	COG2252	PERMEase
BW733_RS11215	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BW733_RS11230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BW733_RS11245	COG1321	iron dependent repressor
BW733_RS11250	COG2226	methyltransferase
BW733_RS11260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW733_RS11265	COG0493	'glutamate synthase
BW733_RS11265	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BW733_RS11270	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BW733_RS11270	COG1013	pyruvate-flavodoxin oxidoreductase activity
BW733_RS11270	COG0674	pyruvate-flavodoxin oxidoreductase activity
BW733_RS11270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BW733_RS11275	COG0167	dihydroorotate dehydrogenase activity
BW733_RS11320	COG2801	Transposase and inactivated derivatives
BW733_RS11340	COG2132	Multicopper oxidase
BW733_RS11360	COG1970	mechanosensitive ion channel activity
BW733_RS11425	COG0138	bifunctional purine biosynthesis protein purh
BW733_RS11430	COG1309	transcriptional regulator
BW733_RS11435	COG0702	epimerase
BW733_RS11445	COG3328	transposase activity
BW733_RS11480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BW733_RS11500	COG2217	Heavy metal translocating P-type atpase
BW733_RS11535	COG2233	PERMEase
BW733_RS11540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BW733_RS11540	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BW733_RS11560	COG0084	hydrolase, TatD family'
BW733_RS11565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BW733_RS11570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BW733_RS11575	COG1846	Transcriptional regulator
BW733_RS11580	COG1309	transcriptional regulator
BW733_RS11590	COG2818	Glycosylase
BW733_RS11610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BW733_RS11615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BW733_RS11630	COG1136	(ABC) transporter
BW733_RS11650	COG0477	Major facilitator Superfamily
BW733_RS11655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BW733_RS11670	COG1609	Transcriptional regulator
BW733_RS11695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BW733_RS11700	COG0193	aminoacyl-tRNA hydrolase activity
BW733_RS11720	COG3956	TIGRFAM MazG family protein
BW733_RS11725	COG0148	phosphopyruvate hydratase activity
BW733_RS11755	COG2801	Transposase and inactivated derivatives
BW733_RS11765	COG1780	Probably involved in ribonucleotide reductase function
BW733_RS11770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BW733_RS11775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BW733_RS11800	COG1028	Short-chain dehydrogenase reductase Sdr
BW733_RS11810	COG2268	Band 7 protein
BW733_RS11885	COG2321	neutral zinc metallopeptidase
BW733_RS11905	COG1254	Belongs to the acylphosphatase family
BW733_RS11920	COG0582	viral genome integration into host DNA
BW733_RS11950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW733_RS11960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BW733_RS11975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BW733_RS11985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW733_RS11995	COG1331	Highly conserved protein containing a thioredoxin domain
BW733_RS12020	COG0582	viral genome integration into host DNA
BW733_RS12035	COG1793	dna ligase
BW733_RS12080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BW733_RS12095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BW733_RS12105	COG1722	exodeoxyribonuclease VII activity
BW733_RS12110	COG1570	exodeoxyribonuclease VII activity
BW733_RS12115	COG0561	phosphatase activity
BW733_RS12125	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BW733_RS12140	COG1322	Protein conserved in bacteria
BW733_RS12155	COG1362	aminopeptidase activity
BW733_RS12160	COG2801	Transposase and inactivated derivatives
BW733_RS12160	COG3415	Transposase
BW733_RS12165	COG1362	aminopeptidase activity
BW733_RS12190	COG0012	GTP binding
BW733_RS12215	COG3328	transposase activity
BW733_RS12240	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BW733_RS12255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BW733_RS12265	COG0019	diaminopimelate decarboxylase activity
BW733_RS12270	COG1902	pentaerythritol trinitrate reductase activity
BW733_RS12290	COG0534	Mate efflux family protein
BW733_RS12310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BW733_RS12320	COG2801	Transposase and inactivated derivatives
BW733_RS12345	COG0582	viral genome integration into host DNA
BW733_RS12350	COG2226	methyltransferase
BW733_RS12385	COG1192	Involved in chromosome partitioning
BW733_RS12405	COG1132	(ABC) transporter
BW733_RS12410	COG1132	(ABC) transporter
BW733_RS12460	COG1045	serine acetyltransferase
BW733_RS12495	COG1335	isochorismatase
BW733_RS12510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW733_RS12525	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BW733_RS12540	COG0616	signal peptide processing
BW733_RS12565	COG2171	N-acyltransferase activity
BW733_RS12610	COG1305	Transglutaminase-like
BW733_RS12615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BW733_RS12620	COG1611	Belongs to the LOG family
BW733_RS12635	COG0297	glycogen (starch) synthase activity
BW733_RS12640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BW733_RS12665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BW733_RS12670	COG1595	DNA-templated transcription, initiation
BW733_RS12680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BW733_RS12685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BW733_RS12710	COG2239	Acts as a magnesium transporter
BW733_RS12720	COG2264	protein methyltransferase activity
BW733_RS12730	COG0006	proline dipeptidase activity
BW733_RS12735	COG2860	membrane
BW733_RS12740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BW733_RS12745	COG1072	(Pantothenic acid kinase))
BW733_RS12750	COG0736	holo-[acyl-carrier-protein] synthase activity
BW733_RS12765	COG2801	Transposase and inactivated derivatives
BW733_RS12770	COG0513	Belongs to the DEAD box helicase family
BW733_RS12775	COG0802	atpase or kinase
BW733_RS12790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BW733_RS12795	COG0747	negative chemotaxis
BW733_RS12800	COG0601	transmembrane transport
BW733_RS12805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW733_RS12810	COG4172	Belongs to the ABC transporter superfamily
BW733_RS12840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BW733_RS12860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BW733_RS12865	COG0459	protein refolding
BW733_RS12870	COG0210	DNA helicase
BW733_RS12880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW733_RS12915	COG0516	GMP reductase activity
BW733_RS12920	COG1605	Chorismate mutase
BW733_RS12920	COG0287	Prephenate dehydrogenase
BW733_RS12935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BW733_RS12945	COG1131	(ABC) transporter
BW733_RS12965	COG0519	Catalyzes the synthesis of GMP from XMP
BW733_RS12965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BW733_RS12990	COG2197	response regulator
BW733_RS13020	COG0045	succinate-CoA ligase (ADP-forming) activity
BW733_RS13045	COG0138	bifunctional purine biosynthesis protein purh
BW733_RS13050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BW733_RS13065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW733_RS13075	COG0395	ABC-type sugar transport system, permease component
BW733_RS13080	COG1175	transmembrane transport
BW733_RS13095	COG1486	melibiose metabolic process
BW733_RS13110	COG0039	L-malate dehydrogenase activity
BW733_RS13115	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BW733_RS13125	COG1253	flavin adenine dinucleotide binding
BW733_RS13135	COG1744	ABC transporter substrate-binding protein PnrA-like
BW733_RS13140	COG3845	ABC transporter
BW733_RS13145	COG4603	Belongs to the binding-protein-dependent transport system permease family
BW733_RS13150	COG1079	Belongs to the binding-protein-dependent transport system permease family
BW733_RS13160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BW733_RS13170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BW733_RS13180	COG0328	RNA-DNA hybrid ribonuclease activity
BW733_RS13195	COG0024	Methionine aminopeptidase
BW733_RS13200	COG3012	SEC-C Motif Domain Protein
BW733_RS13240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW733_RS13265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW733_RS13280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BW733_RS13295	COG4770	biotin carboxylase activity
BW733_RS13315	COG1595	DNA-templated transcription, initiation
BW733_RS13330	COG0424	maF-like protein
BW733_RS13340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BW733_RS13370	COG1316	TRANSCRIPTIONal
BW733_RS13400	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BW733_RS13400	COG0662	Cupin 2, conserved barrel domain protein
BW733_RS13440	COG2835	tetraacyldisaccharide 4'-kinase activity
BW733_RS13450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BW733_RS13465	COG2814	Major facilitator Superfamily
BW733_RS13470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BW733_RS13470	COG0515	serine threonine protein kinase
BW733_RS13520	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BW733_RS13530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BW733_RS13535	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BW733_RS13540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BW733_RS13545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BW733_RS13555	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BW733_RS13565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BW733_RS13620	COG1739	Uncharacterized protein family UPF0029
BW733_RS13640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW733_RS13650	COG2801	Transposase and inactivated derivatives
BW733_RS13660	COG2801	Transposase and inactivated derivatives
BW733_RS13680	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BW733_RS13700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BW733_RS13725	COG0582	viral genome integration into host DNA
BW733_RS13770	COG1192	Involved in chromosome partitioning
BW733_RS13845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BW733_RS13865	COG1595	DNA-templated transcription, initiation
BW733_RS13870	COG0277	FAD linked oxidase domain protein
BW733_RS13890	COG1129	ABC transporter
BW733_RS13900	COG2885	chlorophyll binding
BW733_RS13915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BW733_RS13920	COG1201	RNA secondary structure unwinding
BW733_RS13925	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BW733_RS13930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BW733_RS13935	COG0540	Belongs to the ATCase OTCase family
BW733_RS13940	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BW733_RS13950	COG2814	Major facilitator Superfamily
BW733_RS13960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BW733_RS13965	COG0698	ribose 5-phosphate isomerase
BW733_RS14010	COG1403	HNH endonuclease
BW733_RS14030	COG0544	peptidyl-prolyl cis-trans isomerase activity
BW733_RS14035	COG0628	permease
BW733_RS14040	COG0740	serine-type endopeptidase activity
BW733_RS14045	COG0740	serine-type endopeptidase activity
BW733_RS14050	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BW733_RS14055	COG0793	Belongs to the peptidase S41A family
BW733_RS14055	COG4946	Tricorn protease homolog
BW733_RS14060	COG0525	valine-tRNA ligase activity
BW733_RS14080	COG0285	dihydrofolate synthase activity
BW733_RS14090	COG0105	UTP biosynthetic process
BW733_RS14120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BW733_RS14125	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW733_RS14125	COG0596	Alpha beta hydrolase
BW733_RS14130	COG4868	Belongs to the UPF0371 family
BW733_RS14135	COG2807	transmembrane transport
BW733_RS14145	COG1530	ribonuclease E activity
BW733_RS14150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BW733_RS14155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BW733_RS14160	COG0742	ribosomal rna small subunit methyltransferase
BW733_RS14170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BW733_RS14185	COG2801	Transposase and inactivated derivatives
BW733_RS14200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BW733_RS14205	COG0571	ribonuclease III activity
BW733_RS14210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BW733_RS14250	COG0514	ATP-dependent DNA helicase (RecQ)
BW733_RS14270	COG0616	signal peptide processing
BW733_RS14280	COG0228	four-way junction DNA binding
BW733_RS14285	COG1837	Belongs to the UPF0109 family
BW733_RS14290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BW733_RS14295	COG0336	Belongs to the RNA methyltransferase TrmD family
BW733_RS14305	COG1053	succinate dehydrogenase
BW733_RS14310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BW733_RS14315	COG2801	Transposase and inactivated derivatives
BW733_RS14320	COG1484	DNA-dependent DNA replication
BW733_RS14335	COG0335	large ribosomal subunit rRNA binding
BW733_RS14340	COG0681	Belongs to the peptidase S26 family
BW733_RS14355	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BW733_RS14365	COG0792	nuclease activity
BW733_RS14395	COG3845	ABC transporter
BW733_RS14460	COG1595	DNA-templated transcription, initiation
BW733_RS14465	COG3328	transposase activity
BW733_RS14475	COG1136	(ABC) transporter
BW733_RS14475	COG0577	efflux transmembrane transporter activity
BW733_RS14485	COG1136	(ABC) transporter
BW733_RS14495	COG1129	ABC transporter
BW733_RS14510	COG2197	response regulator
BW733_RS14515	COG4585	Histidine kinase
BW733_RS14535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BW733_RS14600	COG0667	Aldo Keto reductase
BW733_RS14605	COG1968	undecaprenyl-diphosphatase activity
BW733_RS14610	COG0588	phosphoglycerate mutase activity
BW733_RS14625	COG0215	cysteine-tRNA ligase activity
BW733_RS14630	COG0140	phosphoribosyl-ATP diphosphatase activity
BW733_RS14635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BW733_RS14650	COG2801	Transposase and inactivated derivatives
BW733_RS14650	COG3415	Transposase
BW733_RS14660	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BW733_RS14665	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BW733_RS14670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BW733_RS14680	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BW733_RS14685	COG0072	phenylalanine-tRNA ligase activity
BW733_RS14685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW733_RS14730	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BW733_RS14735	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BW733_RS14740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BW733_RS14745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BW733_RS14755	COG0165	Argininosuccinate lyase
BW733_RS14760	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BW733_RS14765	COG2801	Transposase and inactivated derivatives
BW733_RS14770	COG2801	Transposase and inactivated derivatives
BW733_RS14810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BW733_RS14815	COG0497	DNA recombination
BW733_RS14820	COG0504	CTP synthase activity
BW733_RS14825	COG0494	nUDIX hydrolase
BW733_RS14830	COG4974	Belongs to the 'phage' integrase family
BW733_RS14835	COG4552	Acetyltransferase involved in intracellular survival and related
BW733_RS14855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BW733_RS14865	COG0545	Peptidyl-prolyl cis-trans isomerase
BW733_RS14870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BW733_RS14875	COG2378	regulation of single-species biofilm formation
BW733_RS14890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BW733_RS14895	COG0805	protein transport
BW733_RS14905	COG4581	dead DEAH box helicase
BW733_RS14910	COG0107	imidazoleglycerol-phosphate synthase activity
BW733_RS14915	COG0537	adenosine 5'-monophosphoramidase activity
BW733_RS14930	COG0440	acetolactate synthase activity
BW733_RS14935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BW733_RS14945	COG1063	alcohol dehydrogenase
BW733_RS14950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BW733_RS14955	COG1349	DNA-binding transcription factor activity
BW733_RS14980	COG0473	3-isopropylmalate dehydrogenase activity
BW733_RS14985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BW733_RS14990	COG0179	Fumarylacetoacetate (FAA) hydrolase
BW733_RS14995	COG1266	CAAX protease self-immunity
BW733_RS15015	COG1414	Transcriptional regulator
BW733_RS15020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BW733_RS15025	COG0066	3-isopropylmalate dehydratase activity
BW733_RS15035	COG1505	serine-type exopeptidase activity
BW733_RS15040	COG1396	sequence-specific DNA binding
BW733_RS15045	COG0740	serine-type endopeptidase activity
BW733_RS15050	COG0740	serine-type endopeptidase activity
BW733_RS15055	COG0204	Acyl-transferase
BW733_RS15060	COG1181	Belongs to the D-alanine--D-alanine ligase family
BW733_RS15080	COG1674	ftsk spoiiie
BW733_RS15085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW733_RS15095	COG1546	Belongs to the CinA family
BW733_RS15095	COG1058	Belongs to the CinA family
BW733_RS15100	COG1396	sequence-specific DNA binding
BW733_RS15105	COG1349	DNA-binding transcription factor activity
BW733_RS15120	COG2137	regulation of response to DNA damage stimulus
BW733_RS15125	COG1418	mRNA catabolic process
BW733_RS15130	COG2017	converts alpha-aldose to the beta-anomer
BW733_RS15140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW733_RS15165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BW733_RS15170	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BW733_RS15175	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BW733_RS15185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BW733_RS15195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BW733_RS15200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BW733_RS15210	COG4974	Belongs to the 'phage' integrase family
BW733_RS15215	COG0582	viral genome integration into host DNA
BW733_RS15220	COG0582	viral genome integration into host DNA
BW733_RS15225	COG3328	transposase activity
BW733_RS15270	COG5426	von Willebrand factor, type A
BW733_RS15280	COG0129	dihydroxy-acid dehydratase activity
BW733_RS15285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BW733_RS15290	COG0598	Magnesium transport protein CorA
BW733_RS15300	COG1492	cobalamin metabolic process
BW733_RS15305	COG1492	cobalamin metabolic process
BW733_RS15310	COG4989	oxidoreductase activity
BW733_RS15325	COG0535	radical SAM domain protein
BW733_RS15335	COG3693	PFAM glycoside hydrolase, family 10
BW733_RS15335	COG3507	Belongs to the glycosyl hydrolase 43 family
BW733_RS15335	COG2382	esterase
BW733_RS15350	COG1643	Atp-dependent helicase
BW733_RS15355	COG1946	Acyl-CoA thioesterase
BW733_RS15365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BW733_RS15375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BW733_RS15375	COG0519	Catalyzes the synthesis of GMP from XMP
BW733_RS15380	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BW733_RS15395	COG1074	ATP-dependent DNA helicase activity
BW733_RS15400	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BW733_RS15430	COG1615	UPF0182 protein
BW733_RS15450	COG0667	Aldo Keto reductase
BW733_RS15460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW733_RS15495	COG1609	Transcriptional regulator
BW733_RS15500	COG4129	membrane
BW733_RS15515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW733_RS15520	COG0444	Belongs to the ABC transporter superfamily
BW733_RS15525	COG4608	Belongs to the ABC transporter superfamily
BW733_RS15540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BW733_RS15545	COG0483	inositol monophosphate 1-phosphatase activity
BW733_RS15555	COG1162	GTPase activity
BW733_RS15560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BW733_RS15570	COG2135	peptidase activity
BW733_RS15575	COG1595	DNA-templated transcription, initiation
BW733_RS15600	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BW733_RS15605	COG0567	Dehydrogenase, E1 component
BW733_RS15605	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW733_RS15620	COG0019	diaminopimelate decarboxylase activity
BW733_RS15625	COG0460	homoserine dehydrogenase
BW733_RS15630	COG0083	homoserine kinase activity
BW733_RS15640	COG0254	rRNA binding
BW733_RS15645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BW733_RS15650	COG2890	protein-(glutamine-N5) methyltransferase activity
BW733_RS15655	COG0009	L-threonylcarbamoyladenylate synthase
BW733_RS15670	COG0356	it plays a direct role in the translocation of protons across the membrane
BW733_RS15680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BW733_RS15685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BW733_RS15690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BW733_RS15695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BW733_RS15700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BW733_RS15705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BW733_RS15735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BW733_RS15740	COG0596	Alpha beta hydrolase
BW733_RS15805	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BW733_RS15810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BW733_RS15820	COG0366	Alpha amylase catalytic
BW733_RS15835	COG0789	Transcriptional regulator
BW733_RS15840	COG0482	sulfurtransferase activity
BW733_RS15855	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BW733_RS15860	COG0154	amidase activity
BW733_RS15865	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BW733_RS15870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BW733_RS15890	COG3344	reverse transcriptase
BW733_RS15900	COG0582	viral genome integration into host DNA
BW733_RS15905	COG0133	tryptophan synthase activity
BW733_RS15915	COG2258	MOSC domain
BW733_RS15920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BW733_RS15925	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BW733_RS15940	COG0134	indole-3-glycerol-phosphate synthase activity
BW733_RS15945	COG0133	tryptophan synthase activity
BW733_RS15965	COG0067	glutamate synthase
BW733_RS15965	COG0069	glutamate synthase activity
BW733_RS15965	COG0070	glutamate synthase
BW733_RS15975	COG0698	ribose 5-phosphate isomerase
BW733_RS15980	COG0587	DNA-directed DNA polymerase activity
BW733_RS15990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BW733_RS15995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BW733_RS16000	COG0131	Imidazoleglycerol-phosphate dehydratase
BW733_RS16005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BW733_RS16010	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BW733_RS16035	COG0217	transcriptional regulatory protein
BW733_RS16040	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BW733_RS16045	COG0632	four-way junction helicase activity
BW733_RS16050	COG2255	four-way junction helicase activity
BW733_RS16055	COG1862	Preprotein translocase
BW733_RS16060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BW733_RS16065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BW733_RS16070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BW733_RS16080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BW733_RS16085	COG1196	nuclear chromosome segregation
BW733_RS16090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW733_RS16095	COG0124	histidyl-tRNA synthetase
BW733_RS16105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BW733_RS16115	COG2814	Major facilitator Superfamily
BW733_RS16140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BW733_RS16145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BW733_RS16155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BW733_RS16160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BW733_RS16165	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BW733_RS16170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BW733_RS16195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW733_RS16205	COG0477	Major facilitator Superfamily
BW733_RS16215	COG2313	pseudouridylate synthase activity
BW733_RS16220	COG0583	DNA-binding transcription factor activity
BW733_RS16230	COG1690	Belongs to the RtcB family
BW733_RS16245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BW733_RS16250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BW733_RS16255	COG0505	Belongs to the CarA family
BW733_RS16260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BW733_RS16265	COG0167	dihydroorotate dehydrogenase activity
BW733_RS16270	COG0284	orotidine-5'-phosphate decarboxylase activity
BW733_RS16280	COG0194	GDP metabolic process
BW733_RS16285	COG1758	RNA polymerase activity
BW733_RS16290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BW733_RS16300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BW733_RS16325	COG3189	MarR family transcriptional regulator
BW733_RS16330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BW733_RS16340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BW733_RS16350	COG1349	DNA-binding transcription factor activity
BW733_RS16355	COG0698	ribose 5-phosphate isomerase
BW733_RS16365	COG0647	UMP catabolic process
BW733_RS16370	COG1069	ribulokinase activity
BW733_RS16375	COG0371	Dehydrogenase
BW733_RS16390	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BW733_RS16395	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BW733_RS16405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BW733_RS16415	COG1160	GTP binding
BW733_RS16440	COG2255	four-way junction helicase activity
BW733_RS16470	COG0542	response to heat
BW733_RS16500	COG3415	Transposase
BW733_RS16500	COG2801	Transposase and inactivated derivatives
BW733_RS16510	COG1609	Transcriptional regulator
BW733_RS16520	COG1175	transmembrane transport
BW733_RS16525	COG0395	ABC-type sugar transport system, permease component
BW733_RS16530	COG1621	beta-fructofuranosidase activity
BW733_RS16535	COG2197	response regulator
BW733_RS16540	COG4585	Histidine kinase
BW733_RS16545	COG2409	Drug exporters of the RND superfamily
BW733_RS16555	COG0545	Peptidyl-prolyl cis-trans isomerase
BW733_RS16560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BW733_RS16575	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BW733_RS16580	COG3657	addiction module killer protein
BW733_RS16650	COG0647	UMP catabolic process
BW733_RS16665	COG1653	transport
BW733_RS16670	COG1175	transmembrane transport
BW733_RS16675	COG0395	ABC-type sugar transport system, permease component
BW733_RS16695	COG2873	o-acetylhomoserine
BW733_RS16715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BW733_RS16720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BW733_RS16720	COG2813	Specifically methylates the guanine in position
BW733_RS16725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BW733_RS16735	COG1216	Glycosyl transferase, family 2
BW733_RS16740	COG3030	protein affecting phage T7 exclusion by the F plasmid
BW733_RS16755	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BW733_RS16760	COG1410	methionine synthase
BW733_RS16760	COG0646	methionine synthase
BW733_RS16765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BW733_RS16780	COG0667	Aldo Keto reductase
BW733_RS16830	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BW733_RS16865	COG0537	adenosine 5'-monophosphoramidase activity
BW733_RS16910	COG0009	L-threonylcarbamoyladenylate synthase
BW733_RS16930	COG1295	ribonuclease BN
BW733_RS16950	COG1716	ATPase activity
BW733_RS16975	COG0438	transferase activity, transferring glycosyl groups
BW733_RS16990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BW733_RS16995	COG1024	Enoyl-CoA hydratase
BW733_RS17000	COG1028	Short-chain dehydrogenase reductase Sdr
BW733_RS17040	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW733_RS17050	COG0673	inositol 2-dehydrogenase activity
BW733_RS17055	COG1940	carbohydrate kinase activity
BW733_RS17130	COG3547	Transposase (IS116 IS110 IS902 family)
BW733_RS17135	COG3328	transposase activity
BW733_RS17175	COG2801	Transposase and inactivated derivatives
BW733_RS17195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW733_RS17205	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BW733_RS17210	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BW733_RS17215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BW733_RS17225	COG0477	Major facilitator Superfamily
BW733_RS17230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BW733_RS17235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BW733_RS17240	COG0531	amino acid
BW733_RS17245	COG0569	domain protein
BW733_RS17270	COG0756	dUTP diphosphatase activity
BW733_RS17300	COG1435	thymidine kinase activity
BW733_RS17325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BW733_RS17340	COG1620	l-lactate permease
BW733_RS17345	COG0247	lactate metabolic process
BW733_RS17350	COG1139	Iron-sulfur cluster binding protein
BW733_RS17355	COG1556	Lactate utilization protein
BW733_RS17360	COG0187	DNA topoisomerase II activity
BW733_RS17375	COG0210	DNA helicase
BW733_RS17385	COG1793	dna ligase
BW733_RS17385	COG3285	dna ligase
BW733_RS17405	COG0180	Tryptophanyl-tRNA synthetase
BW733_RS17410	COG0613	PHP domain protein
BW733_RS17480	COG5401	PFAM Sporulation and spore germination
BW733_RS17605	COG0205	6-phosphofructokinase activity
BW733_RS17620	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BW733_RS17625	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)