locus-tag	class	description
RPIT_RS00005	COG0175	sulfate reduction
RPIT_RS00015	COG0730	response to heat
RPIT_RS00025	COG0674	pyruvate-flavodoxin oxidoreductase activity
RPIT_RS00025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RPIT_RS00030	COG1013	pyruvate-flavodoxin oxidoreductase activity
RPIT_RS00035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RPIT_RS00035	COG1648	precorrin-2 dehydrogenase activity
RPIT_RS00040	COG1648	precorrin-2 dehydrogenase activity
RPIT_RS00040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RPIT_RS00065	COG0737	Belongs to the 5'-nucleotidase family
RPIT_RS00080	COG2755	lipolytic protein G-D-S-L family
RPIT_RS00095	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RPIT_RS00115	COG2890	protein-(glutamine-N5) methyltransferase activity
RPIT_RS00155	COG1793	dna ligase
RPIT_RS00170	COG1793	dna ligase
RPIT_RS00190	COG0531	amino acid
RPIT_RS00195	COG0366	Alpha amylase catalytic
RPIT_RS00220	COG3328	transposase activity
RPIT_RS00275	COG2197	response regulator
RPIT_RS00300	COG4044	May play a role in the intracellular transport of hydrophobic ligands
RPIT_RS00330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RPIT_RS00335	COG0737	Belongs to the 5'-nucleotidase family
RPIT_RS00335	COG4085	toxin activity
RPIT_RS00335	COG1525	nuclease
RPIT_RS00345	COG0022	dehydrogenase e1 component
RPIT_RS00350	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIT_RS00360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RPIT_RS00370	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RPIT_RS00375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RPIT_RS00405	COG0077	Prephenate dehydratase
RPIT_RS00410	COG1597	lipid kinase activity
RPIT_RS00410	COG1803	Methylglyoxal synthase
RPIT_RS00415	COG2814	Major facilitator Superfamily
RPIT_RS00420	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RPIT_RS00425	COG0561	phosphatase activity
RPIT_RS00430	COG0693	protein deglycase activity
RPIT_RS00440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIT_RS00455	COG0137	argininosuccinate synthase activity
RPIT_RS00470	COG1216	Glycosyl transferase, family 2
RPIT_RS00470	COG0463	Glycosyl transferase, family 2
RPIT_RS00480	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RPIT_RS00485	COG3708	Transcriptional regulator
RPIT_RS00485	COG2207	Transcriptional regulator
RPIT_RS00530	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RPIT_RS00535	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RPIT_RS00555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIT_RS00560	COG1215	transferase activity, transferring glycosyl groups
RPIT_RS00575	COG0673	inositol 2-dehydrogenase activity
RPIT_RS00585	COG1063	alcohol dehydrogenase
RPIT_RS00590	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RPIT_RS00600	COG0604	alcohol dehydrogenase
RPIT_RS00600	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_RS00600	COG3321	synthase
RPIT_RS00605	COG0166	Belongs to the GPI family
RPIT_RS00610	COG2949	membrane
RPIT_RS00615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RPIT_RS00620	COG0569	domain protein
RPIT_RS00625	COG1349	DNA-binding transcription factor activity
RPIT_RS00635	COG0018	arginyl-trna synthetase
RPIT_RS00655	COG0205	6-phosphofructokinase activity
RPIT_RS00670	COG3525	Glycosyl hydrolase, family 20, catalytic domain
RPIT_RS00670	COG3291	Pkd domain containing protein
RPIT_RS00680	COG0546	phosphoglycolate phosphatase activity
RPIT_RS00695	COG1464	Belongs to the NlpA lipoprotein family
RPIT_RS00700	COG2011	ABC-type metal ion transport system permease component
RPIT_RS00705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RPIT_RS00720	COG1793	dna ligase
RPIT_RS00725	COG2095	MarC family integral membrane protein
RPIT_RS00730	COG1473	amidohydrolase
RPIT_RS00745	COG0560	Phosphoserine phosphatase
RPIT_RS00750	COG0659	secondary active sulfate transmembrane transporter activity
RPIT_RS00755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RPIT_RS00760	COG2813	Specifically methylates the guanine in position
RPIT_RS00775	COG0644	oxidoreductase
RPIT_RS00780	COG1649	PFAM Uncharacterised BCR, COG1649
RPIT_RS00795	COG2124	cytochrome p450
RPIT_RS00825	COG0515	serine threonine protein kinase
RPIT_RS00840	COG1752	Esterase of the alpha-beta hydrolase superfamily
RPIT_RS00870	COG1609	Transcriptional regulator
RPIT_RS00875	COG0673	inositol 2-dehydrogenase activity
RPIT_RS00885	COG2233	PERMEase
RPIT_RS00905	COG0737	Belongs to the 5'-nucleotidase family
RPIT_RS00905	COG4085	toxin activity
RPIT_RS00905	COG1525	nuclease
RPIT_RS00975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPIT_RS00995	COG1802	Transcriptional regulator
RPIT_RS01010	COG2197	response regulator
RPIT_RS01015	COG4585	Histidine kinase
RPIT_RS01025	COG1131	(ABC) transporter
RPIT_RS01040	COG1175	transmembrane transport
RPIT_RS01045	COG0395	ABC-type sugar transport system, permease component
RPIT_RS01085	COG0247	lactate metabolic process
RPIT_RS01090	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
RPIT_RS01095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RPIT_RS01180	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RPIT_RS01185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RPIT_RS01195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPIT_RS01205	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
RPIT_RS01210	COG1131	(ABC) transporter
RPIT_RS01225	COG0281	malic enzyme
RPIT_RS01235	COG0673	inositol 2-dehydrogenase activity
RPIT_RS01240	COG0647	UMP catabolic process
RPIT_RS01245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RPIT_RS01255	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RPIT_RS01260	COG0671	phosphoesterase, PA-phosphatase related
RPIT_RS01270	COG1879	ABC-type sugar transport system periplasmic component
RPIT_RS01280	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIT_RS01305	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
RPIT_RS01335	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RPIT_RS01395	COG1111	helicase
RPIT_RS01395	COG1205	dead DEAH box helicase
RPIT_RS01415	COG0667	Aldo Keto reductase
RPIT_RS01425	COG4133	protoheme IX ABC transporter activity
RPIT_RS01430	COG1754	DNA topoisomerase type I activity
RPIT_RS01430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RPIT_RS01440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RPIT_RS01450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RPIT_RS01460	COG1774	PSP1 C-terminal conserved region
RPIT_RS01475	COG1231	oxidoreductase activity
RPIT_RS01505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RPIT_RS01510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RPIT_RS01515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RPIT_RS01520	COG2027	D-alanyl-D-alanine carboxypeptidase
RPIT_RS01530	COG0037	tRNA processing
RPIT_RS01545	COG0302	gtp cyclohydrolase
RPIT_RS01550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RPIT_RS01555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RPIT_RS01570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RPIT_RS01580	COG0649	NAD binding
RPIT_RS01595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RPIT_RS01600	COG3842	ATPase activity
RPIT_RS01605	COG4143	(ABC) transporter
RPIT_RS01610	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
RPIT_RS01625	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RPIT_RS01655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RPIT_RS01670	COG1648	precorrin-2 dehydrogenase activity
RPIT_RS01670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RPIT_RS01675	COG0406	alpha-ribazole phosphatase activity
RPIT_RS01680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RPIT_RS01685	COG0785	Cytochrome C biogenesis protein
RPIT_RS01690	COG1333	cytochrome c biogenesis protein
RPIT_RS01695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RPIT_RS01705	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_RS01720	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_RS01725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RPIT_RS01750	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RPIT_RS01755	COG0456	acetyltransferase
RPIT_RS01760	COG0745	RESPONSE REGULATOR receiver
RPIT_RS01770	COG1490	D-aminoacyl-tRNA deacylase activity
RPIT_RS01775	COG3485	protocatechuate 3,4-dioxygenase
RPIT_RS01785	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RPIT_RS01790	COG2326	polyphosphate kinase activity
RPIT_RS01815	COG1217	gtp-binding protein TYPA
RPIT_RS01835	COG1461	Dihydroxyacetone kinase
RPIT_RS01840	COG2376	Dihydroxyacetone kinase
RPIT_RS01845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RPIT_RS01860	COG0395	ABC-type sugar transport system, permease component
RPIT_RS01865	COG1175	transmembrane transport
RPIT_RS01870	COG1653	transport
RPIT_RS01875	COG0151	Belongs to the GarS family
RPIT_RS01900	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_RS01910	COG3012	SEC-C Motif Domain Protein
RPIT_RS01915	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RPIT_RS01920	COG0318	PFAM AMP-dependent synthetase and ligase
RPIT_RS01945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RPIT_RS01955	COG2094	Belongs to the DNA glycosylase MPG family
RPIT_RS01960	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RPIT_RS01965	COG0047	phosphoribosylformylglycinamidine synthase activity
RPIT_RS01980	COG1404	Belongs to the peptidase S8 family
RPIT_RS01985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RPIT_RS02005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPIT_RS02025	COG2070	2-Nitropropane dioxygenase
RPIT_RS02035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RPIT_RS02040	COG0366	Alpha amylase catalytic
RPIT_RS02060	COG1175	transmembrane transport
RPIT_RS02065	COG3833	ABC-type maltose transport systems, permease component
RPIT_RS02070	COG0791	NLP P60 protein
RPIT_RS02080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RPIT_RS02085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RPIT_RS02105	COG1140	nitrate reductase beta subunit
RPIT_RS02265	COG1131	(ABC) transporter
RPIT_RS02290	COG0315	cyclic pyranopterin monophosphate synthase activity
RPIT_RS02295	COG0521	Mo-molybdopterin cofactor biosynthetic process
RPIT_RS02300	COG1136	(ABC) transporter
RPIT_RS02305	COG1136	(ABC) transporter
RPIT_RS02305	COG0577	efflux transmembrane transporter activity
RPIT_RS02335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RPIT_RS02350	COG1846	Transcriptional regulator
RPIT_RS02355	COG2814	Major facilitator Superfamily
RPIT_RS02360	COG2838	Isocitrate dehydrogenase
RPIT_RS02375	COG3005	denitrification pathway
RPIT_RS02390	COG1333	cytochrome c biogenesis protein
RPIT_RS02395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RPIT_RS02425	COG2056	Na+-H+ antiporter family
RPIT_RS02435	COG0459	protein refolding
RPIT_RS02460	COG0366	Alpha amylase catalytic
RPIT_RS02465	COG0366	Alpha amylase catalytic
RPIT_RS02490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RPIT_RS02495	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RPIT_RS02500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RPIT_RS02505	COG1461	Dihydroxyacetone kinase
RPIT_RS02525	COG4948	Mandelate Racemase Muconate Lactonizing
RPIT_RS02530	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
RPIT_RS02540	COG2226	methyltransferase
RPIT_RS02555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RPIT_RS02565	COG1169	isochorismate synthase
RPIT_RS02570	COG0644	oxidoreductase
RPIT_RS02580	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIT_RS02585	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIT_RS02590	COG0649	NAD binding
RPIT_RS02600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RPIT_RS02610	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RPIT_RS02615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIT_RS02640	COG1007	ATP synthesis coupled electron transport
RPIT_RS02645	COG0142	geranyltranstransferase activity
RPIT_RS02650	COG3590	peptidase
RPIT_RS02655	COG1295	ribonuclease BN
RPIT_RS02660	COG1013	pyruvate-flavodoxin oxidoreductase activity
RPIT_RS02665	COG0674	pyruvate-flavodoxin oxidoreductase activity
RPIT_RS02665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RPIT_RS02675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RPIT_RS02685	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIT_RS02690	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIT_RS02695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIT_RS02710	COG2267	carboxylic ester hydrolase activity
RPIT_RS02715	COG1666	GTP binding
RPIT_RS02730	COG0813	purine-nucleoside phosphorylase activity
RPIT_RS02745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RPIT_RS02750	COG2030	dehydratase
RPIT_RS02760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RPIT_RS02770	COG1473	amidohydrolase
RPIT_RS02780	COG1132	(ABC) transporter
RPIT_RS02785	COG1132	(ABC) transporter
RPIT_RS02800	COG0250	Participates in transcription elongation, termination and antitermination
RPIT_RS02805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RPIT_RS02810	COG0081	regulation of translation
RPIT_RS02815	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RPIT_RS02820	COG1024	Enoyl-CoA hydratase
RPIT_RS02830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RPIT_RS02835	COG1126	abc transporter atp-binding protein
RPIT_RS02840	COG0765	amino acid transport
RPIT_RS02850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RPIT_RS02855	COG0222	ribosome binding
RPIT_RS02860	COG0085	RNA polymerase activity
RPIT_RS02865	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RPIT_RS02870	COG4214	carbohydrate transport
RPIT_RS02880	COG4213	ABC transporter substrate-binding protein
RPIT_RS02885	COG1940	carbohydrate kinase activity
RPIT_RS02885	COG1846	Transcriptional regulator
RPIT_RS02895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RPIT_RS02900	COG0049	tRNA binding
RPIT_RS02905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RPIT_RS02915	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RPIT_RS02930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RPIT_RS02940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPIT_RS02950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPIT_RS02955	COG0435	Glutathione S-transferase
RPIT_RS02985	COG0051	transcription antitermination factor activity, RNA binding
RPIT_RS02990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RPIT_RS02995	COG0088	Forms part of the polypeptide exit tunnel
RPIT_RS03000	COG0089	rRNA binding
RPIT_RS03005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RPIT_RS03010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RPIT_RS03015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RPIT_RS03020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RPIT_RS03025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RPIT_RS03030	COG0255	Belongs to the universal ribosomal protein uL29 family
RPIT_RS03035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RPIT_RS03050	COG0730	response to heat
RPIT_RS03065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RPIT_RS03080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPIT_RS03090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RPIT_RS03095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RPIT_RS03100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RPIT_RS03105	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RPIT_RS03110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RPIT_RS03115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RPIT_RS03120	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RPIT_RS03125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RPIT_RS03130	COG1841	ribosomal large subunit assembly
RPIT_RS03150	COG0024	Methionine aminopeptidase
RPIT_RS03175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RPIT_RS03180	COG3718	enzyme involved in inositol metabolism
RPIT_RS03185	COG3962	Belongs to the TPP enzyme family
RPIT_RS03200	COG0395	ABC-type sugar transport system, permease component
RPIT_RS03205	COG1175	transmembrane transport
RPIT_RS03220	COG1486	melibiose metabolic process
RPIT_RS03240	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIT_RS03245	COG1129	ABC transporter
RPIT_RS03255	COG1082	Xylose isomerase domain protein TIM barrel
RPIT_RS03260	COG0673	inositol 2-dehydrogenase activity
RPIT_RS03270	COG0673	inositol 2-dehydrogenase activity
RPIT_RS03285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPIT_RS03290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPIT_RS03295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RPIT_RS03300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RPIT_RS03305	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RPIT_RS03310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RPIT_RS03320	COG0202	RNA polymerase activity
RPIT_RS03325	COG0203	ribosomal protein L17
RPIT_RS03340	COG4120	Belongs to the binding-protein-dependent transport system permease family
RPIT_RS03345	COG3842	ATPase activity
RPIT_RS03350	COG0438	transferase activity, transferring glycosyl groups
RPIT_RS03360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RPIT_RS03360	COG2755	lipolytic protein G-D-S-L family
RPIT_RS03370	COG2813	Specifically methylates the guanine in position
RPIT_RS03375	COG0101	tRNA pseudouridine synthase activity
RPIT_RS03380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RPIT_RS03385	COG3304	Inner membrane component domain
RPIT_RS03395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RPIT_RS03400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RPIT_RS03405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RPIT_RS03415	COG0557	exoribonuclease II activity
RPIT_RS03435	COG1305	Transglutaminase-like
RPIT_RS03450	COG0174	glutamine synthetase
RPIT_RS03460	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RPIT_RS03465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RPIT_RS03470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPIT_RS03485	COG2409	Drug exporters of the RND superfamily
RPIT_RS03490	COG0174	glutamine synthetase
RPIT_RS03495	COG1823	symporter activity
RPIT_RS03505	COG0488	(ABC) transporter
RPIT_RS03520	COG0321	lipoyl(octanoyl) transferase activity
RPIT_RS03530	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIT_RS03535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RPIT_RS03545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RPIT_RS03585	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RPIT_RS03590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RPIT_RS03605	COG1484	DNA-dependent DNA replication
RPIT_RS03630	COG1668	transmembrane transport
RPIT_RS03635	COG1215	transferase activity, transferring glycosyl groups
RPIT_RS03640	COG4152	abc transporter atp-binding protein
RPIT_RS03655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RPIT_RS03660	COG0723	plastoquinol--plastocyanin reductase activity
RPIT_RS03665	COG2010	Cytochrome c
RPIT_RS03670	COG1845	cytochrome c oxidase, subunit III
RPIT_RS03685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RPIT_RS03695	COG3214	Protein conserved in bacteria
RPIT_RS03700	COG0088	Forms part of the polypeptide exit tunnel
RPIT_RS03710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RPIT_RS03745	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RPIT_RS03760	COG0515	serine threonine protein kinase
RPIT_RS03760	COG2815	serine threonine protein kinase
RPIT_RS03765	COG0352	thiamine-phosphate diphosphorylase activity
RPIT_RS03770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RPIT_RS03775	COG0142	geranyltranstransferase activity
RPIT_RS03790	COG3973	AAA domain
RPIT_RS03795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RPIT_RS03795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RPIT_RS03820	COG1136	(ABC) transporter
RPIT_RS03825	COG1136	(ABC) transporter
RPIT_RS03825	COG0577	efflux transmembrane transporter activity
RPIT_RS03840	COG3547	Transposase (IS116 IS110 IS902 family)
RPIT_RS03845	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RPIT_RS03860	COG1132	(ABC) transporter
RPIT_RS03865	COG0438	transferase activity, transferring glycosyl groups
RPIT_RS03870	COG0297	glycogen (starch) synthase activity
RPIT_RS03870	COG0438	transferase activity, transferring glycosyl groups
RPIT_RS03900	COG0587	DNA-directed DNA polymerase activity
RPIT_RS03905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RPIT_RS03930	COG0714	Associated with various cellular activities
RPIT_RS03935	COG2001	Belongs to the MraZ family
RPIT_RS03940	COG0275	rRNA processing
RPIT_RS03960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RPIT_RS03965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RPIT_RS03970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RPIT_RS03975	COG0772	Belongs to the SEDS family
RPIT_RS03980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RPIT_RS03985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RPIT_RS04000	COG1799	cell septum assembly
RPIT_RS04020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RPIT_RS04030	COG0469	pyruvate kinase activity
RPIT_RS04070	COG0539	negative regulation of cytoplasmic translation
RPIT_RS04075	COG0237	dephospho-CoA kinase activity
RPIT_RS04080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RPIT_RS04080	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RPIT_RS04085	COG0509	glycine decarboxylation via glycine cleavage system
RPIT_RS04090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RPIT_RS04105	COG0556	nucleotide-excision repair
RPIT_RS04115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RPIT_RS04125	COG0322	excinuclease ABC activity
RPIT_RS04130	COG1268	BioY protein
RPIT_RS04135	COG1122	ATPase activity
RPIT_RS04140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RPIT_RS04145	COG1660	Displays ATPase and GTPase activities
RPIT_RS04155	COG1481	regulation of sporulation
RPIT_RS04160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RPIT_RS04165	COG0126	phosphoglycerate kinase activity
RPIT_RS04170	COG0149	triose-phosphate isomerase activity
RPIT_RS04180	COG0765	amino acid transport
RPIT_RS04185	COG0765	amino acid transport
RPIT_RS04195	COG1126	abc transporter atp-binding protein
RPIT_RS04200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RPIT_RS04210	COG0363	glucosamine-6-phosphate deaminase activity
RPIT_RS04250	COG0109	protoheme IX farnesyltransferase activity
RPIT_RS04260	COG2318	DinB family
RPIT_RS04265	COG0339	signal peptide processing
RPIT_RS04295	COG0719	Fe-S assembly protein
RPIT_RS04305	COG0396	ATPase activity
RPIT_RS04310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RPIT_RS04315	COG0822	iron-sulfur transferase activity
RPIT_RS04350	COG0488	(ABC) transporter
RPIT_RS04355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RPIT_RS04360	COG0366	Alpha amylase catalytic
RPIT_RS04365	COG2211	Major facilitator Superfamily
RPIT_RS04365	COG2190	(PTS) system
RPIT_RS04370	COG2226	methyltransferase
RPIT_RS04385	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_RS04395	COG1119	ATPase activity
RPIT_RS04415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RPIT_RS04425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RPIT_RS04430	COG0561	phosphatase activity
RPIT_RS04440	COG0242	peptide deformylase activity
RPIT_RS04445	COG4974	Belongs to the 'phage' integrase family
RPIT_RS04450	COG0739	heme binding
RPIT_RS04450	COG1196	nuclear chromosome segregation
RPIT_RS04450	COG0741	lytic transglycosylase activity
RPIT_RS04455	COG0052	Belongs to the universal ribosomal protein uS2 family
RPIT_RS04460	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RPIT_RS04465	COG0528	UMP kinase activity
RPIT_RS04470	COG0233	cytoplasmic translational termination
RPIT_RS04480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RPIT_RS04485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RPIT_RS04495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RPIT_RS04500	COG0750	zinc metalloprotease
RPIT_RS04505	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RPIT_RS04510	COG0454	-acetyltransferase
RPIT_RS04510	COG0456	acetyltransferase
RPIT_RS04515	COG0442	prolyl-tRNA aminoacylation
RPIT_RS04530	COG0779	Required for maturation of 30S ribosomal subunits
RPIT_RS04560	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RPIT_RS04565	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RPIT_RS04570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RPIT_RS04590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RPIT_RS04595	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RPIT_RS04595	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RPIT_RS04595	COG0506	proline dehydrogenase activity
RPIT_RS04600	COG1185	polyribonucleotide nucleotidyltransferase activity
RPIT_RS04605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RPIT_RS04620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RPIT_RS04625	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RPIT_RS04630	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RPIT_RS04635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RPIT_RS04640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RPIT_RS04650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RPIT_RS04655	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RPIT_RS04665	COG0406	alpha-ribazole phosphatase activity
RPIT_RS04675	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RPIT_RS04680	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RPIT_RS04685	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
RPIT_RS04690	COG0181	hydroxymethylbilane synthase activity
RPIT_RS04695	COG0113	porphobilinogen synthase activity
RPIT_RS04700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RPIT_RS04705	COG0181	hydroxymethylbilane synthase activity
RPIT_RS04730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RPIT_RS04755	COG3409	Peptidoglycan-binding domain 1 protein
RPIT_RS04755	COG3773	Cell wall hydrolase
RPIT_RS04780	COG0495	leucyl-tRNA aminoacylation
RPIT_RS04820	COG0481	GTPase activity
RPIT_RS04825	COG1643	Atp-dependent helicase
RPIT_RS04845	COG1725	Transcriptional regulator
RPIT_RS04850	COG1131	(ABC) transporter
RPIT_RS04865	COG1725	Transcriptional regulator
RPIT_RS04910	COG0483	inositol monophosphate 1-phosphatase activity
RPIT_RS04915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RPIT_RS04920	COG1420	regulation of RNA biosynthetic process
RPIT_RS04925	COG0484	heat shock protein binding
RPIT_RS04935	COG0343	queuine tRNA-ribosyltransferase activity
RPIT_RS04955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RPIT_RS04970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RPIT_RS04985	COG0395	ABC-type sugar transport system, permease component
RPIT_RS04990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RPIT_RS05005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RPIT_RS05010	COG1381	Involved in DNA repair and RecF pathway recombination
RPIT_RS05020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RPIT_RS05025	COG1121	(ABC) transporter
RPIT_RS05030	COG0803	Belongs to the bacterial solute-binding protein 9 family
RPIT_RS05055	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RPIT_RS05060	COG0358	DNA primase activity
RPIT_RS05070	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RPIT_RS05115	COG0714	Associated with various cellular activities
RPIT_RS05125	COG2304	oxidoreductase activity
RPIT_RS05130	COG2304	oxidoreductase activity
RPIT_RS05135	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RPIT_RS05150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RPIT_RS05155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RPIT_RS05160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RPIT_RS05180	COG1115	amino acid carrier protein
RPIT_RS05190	COG1796	DNA polymerase
RPIT_RS05190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RPIT_RS05205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RPIT_RS05215	COG0205	6-phosphofructokinase activity
RPIT_RS05240	COG1610	YqeY-like protein
RPIT_RS05245	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RPIT_RS05250	COG2884	Cell division ATP-binding protein ftsE
RPIT_RS05260	COG1196	nuclear chromosome segregation
RPIT_RS05260	COG0739	heme binding
RPIT_RS05260	COG0741	lytic transglycosylase activity
RPIT_RS05265	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RPIT_RS05280	COG1678	Uncharacterized ACR, COG1678
RPIT_RS05285	COG0745	RESPONSE REGULATOR receiver
RPIT_RS05290	COG5000	phosphorelay sensor kinase activity
RPIT_RS05290	COG5002	protein histidine kinase activity
RPIT_RS05295	COG5401	PFAM Sporulation and spore germination
RPIT_RS05300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RPIT_RS05305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RPIT_RS05310	COG0653	protein targeting
RPIT_RS05345	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
RPIT_RS05360	COG0613	PHP domain protein
RPIT_RS05385	COG3285	dna ligase
RPIT_RS05385	COG1793	dna ligase
RPIT_RS05405	COG1595	DNA-templated transcription, initiation
RPIT_RS05420	COG0187	DNA topoisomerase II activity
RPIT_RS05425	COG1556	Lactate utilization protein
RPIT_RS05430	COG1139	Iron-sulfur cluster binding protein
RPIT_RS05435	COG0247	lactate metabolic process
RPIT_RS05440	COG1620	l-lactate permease
RPIT_RS05445	COG1802	Transcriptional regulator
RPIT_RS05470	COG0438	transferase activity, transferring glycosyl groups
RPIT_RS05475	COG1435	thymidine kinase activity
RPIT_RS05505	COG0756	dUTP diphosphatase activity
RPIT_RS05520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RPIT_RS05540	COG2826	transposase and inactivated derivatives, IS30 family
RPIT_RS05550	COG0569	domain protein
RPIT_RS05555	COG0531	amino acid
RPIT_RS05560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RPIT_RS05565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RPIT_RS05575	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RPIT_RS05590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RPIT_RS05620	COG2860	membrane
RPIT_RS05630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RPIT_RS05635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RPIT_RS05645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RPIT_RS05655	COG1560	Kdo2-lipid A biosynthetic process
RPIT_RS05660	COG0438	transferase activity, transferring glycosyl groups
RPIT_RS05685	COG1716	ATPase activity
RPIT_RS05705	COG1295	ribonuclease BN
RPIT_RS05720	COG0656	L-ascorbic acid biosynthetic process
RPIT_RS05725	COG0009	L-threonylcarbamoyladenylate synthase
RPIT_RS05745	COG1574	metal-dependent hydrolase with the TIM-barrel fold
RPIT_RS05770	COG1793	dna ligase
RPIT_RS05775	COG0395	ABC-type sugar transport system, permease component
RPIT_RS05805	COG0657	acetylesterase activity
RPIT_RS05825	COG2197	response regulator
RPIT_RS05830	COG4585	Histidine kinase
RPIT_RS05845	COG3655	Transcriptional regulator
RPIT_RS05855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RPIT_RS05860	COG1472	Belongs to the glycosyl hydrolase 3 family
RPIT_RS05870	COG3654	unkown
RPIT_RS05880	COG0596	Alpha beta hydrolase
RPIT_RS05895	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_RS05905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RPIT_RS05910	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RPIT_RS05925	COG3030	protein affecting phage T7 exclusion by the F plasmid
RPIT_RS05930	COG1216	Glycosyl transferase, family 2
RPIT_RS05940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RPIT_RS05945	COG2813	Specifically methylates the guanine in position
RPIT_RS05945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RPIT_RS05950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RPIT_RS05965	COG2873	o-acetylhomoserine
RPIT_RS05980	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RPIT_RS06000	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RPIT_RS06030	COG1160	GTP binding
RPIT_RS06035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RPIT_RS06055	COG0546	phosphoglycolate phosphatase activity
RPIT_RS06060	COG1410	methionine synthase
RPIT_RS06060	COG0646	methionine synthase
RPIT_RS06070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RPIT_RS06080	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RPIT_RS06090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RPIT_RS06095	COG1758	RNA polymerase activity
RPIT_RS06100	COG0194	GDP metabolic process
RPIT_RS06110	COG0284	orotidine-5'-phosphate decarboxylase activity
RPIT_RS06115	COG0167	dihydroorotate dehydrogenase activity
RPIT_RS06120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RPIT_RS06125	COG0505	Belongs to the CarA family
RPIT_RS06130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RPIT_RS06135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RPIT_RS06140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RPIT_RS06145	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RPIT_RS06150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RPIT_RS06155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RPIT_RS06160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RPIT_RS06170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RPIT_RS06175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RPIT_RS06195	COG2814	Major facilitator Superfamily
RPIT_RS06200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RPIT_RS06215	COG0124	histidyl-tRNA synthetase
RPIT_RS06220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RPIT_RS06230	COG1196	nuclear chromosome segregation
RPIT_RS06235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RPIT_RS06245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RPIT_RS06250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RPIT_RS06255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RPIT_RS06260	COG1862	Preprotein translocase
RPIT_RS06265	COG2255	four-way junction helicase activity
RPIT_RS06270	COG0632	four-way junction helicase activity
RPIT_RS06275	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RPIT_RS06280	COG0217	transcriptional regulatory protein
RPIT_RS06305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RPIT_RS06310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RPIT_RS06315	COG0131	Imidazoleglycerol-phosphate dehydratase
RPIT_RS06320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RPIT_RS06325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RPIT_RS06335	COG0587	DNA-directed DNA polymerase activity
RPIT_RS06340	COG1840	ABC-type Fe3 transport system, periplasmic component
RPIT_RS06350	COG3842	ATPase activity
RPIT_RS06365	COG0069	glutamate synthase activity
RPIT_RS06365	COG0070	glutamate synthase
RPIT_RS06365	COG0067	glutamate synthase
RPIT_RS06375	COG0159	tryptophan synthase activity
RPIT_RS06380	COG0133	tryptophan synthase activity
RPIT_RS06385	COG0134	indole-3-glycerol-phosphate synthase activity
RPIT_RS06400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RPIT_RS06405	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RPIT_RS06450	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RPIT_RS06455	COG0154	amidase activity
RPIT_RS06460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RPIT_RS06475	COG0482	sulfurtransferase activity
RPIT_RS06480	COG1505	serine-type exopeptidase activity
RPIT_RS06495	COG0366	Alpha amylase catalytic
RPIT_RS06505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RPIT_RS06520	COG0517	IMP dehydrogenase activity
RPIT_RS06575	COG0596	Alpha beta hydrolase
RPIT_RS06585	COG2827	Endonuclease containing a URI domain
RPIT_RS06595	COG2096	Adenosyltransferase
RPIT_RS06605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RPIT_RS06610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RPIT_RS06615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RPIT_RS06620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RPIT_RS06625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RPIT_RS06630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RPIT_RS06640	COG0356	it plays a direct role in the translocation of protons across the membrane
RPIT_RS06650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RPIT_RS06660	COG2890	protein-(glutamine-N5) methyltransferase activity
RPIT_RS06665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RPIT_RS06670	COG0254	rRNA binding
RPIT_RS06680	COG0083	homoserine kinase activity
RPIT_RS06685	COG0460	homoserine dehydrogenase
RPIT_RS06690	COG0019	diaminopimelate decarboxylase activity
RPIT_RS06710	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIT_RS06710	COG0567	Dehydrogenase, E1 component
RPIT_RS06715	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RPIT_RS06740	COG1595	DNA-templated transcription, initiation
RPIT_RS06745	COG2135	peptidase activity
RPIT_RS06760	COG1162	GTPase activity
RPIT_RS06765	COG0483	inositol monophosphate 1-phosphatase activity
RPIT_RS06770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RPIT_RS06780	COG0444	Belongs to the ABC transporter superfamily
RPIT_RS06785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RPIT_RS06795	COG0747	negative chemotaxis
RPIT_RS06800	COG1609	Transcriptional regulator
RPIT_RS06820	COG0667	Aldo Keto reductase
RPIT_RS06835	COG1615	UPF0182 protein
RPIT_RS06845	COG3480	Lon protease (S16) C-terminal proteolytic domain
RPIT_RS06865	COG1074	ATP-dependent DNA helicase activity
RPIT_RS06880	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RPIT_RS06895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RPIT_RS06905	COG1946	Acyl-CoA thioesterase
RPIT_RS06910	COG1643	Atp-dependent helicase
RPIT_RS06940	COG0129	dihydroxy-acid dehydratase activity
RPIT_RS06960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RPIT_RS06965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RPIT_RS06975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RPIT_RS06985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RPIT_RS06990	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RPIT_RS06995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RPIT_RS07010	COG2017	converts alpha-aldose to the beta-anomer
RPIT_RS07015	COG1418	mRNA catabolic process
RPIT_RS07020	COG2137	regulation of response to DNA damage stimulus
RPIT_RS07040	COG1396	sequence-specific DNA binding
RPIT_RS07045	COG1546	Belongs to the CinA family
RPIT_RS07045	COG1058	Belongs to the CinA family
RPIT_RS07055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RPIT_RS07060	COG1674	ftsk spoiiie
RPIT_RS07070	COG1181	Belongs to the D-alanine--D-alanine ligase family
RPIT_RS07090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RPIT_RS07100	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_RS07120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RPIT_RS07170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RPIT_RS07180	COG1230	cation diffusion facilitator family transporter
RPIT_RS07205	COG0745	RESPONSE REGULATOR receiver
RPIT_RS07210	COG2205	protein histidine kinase activity
RPIT_RS07245	COG2217	Heavy metal translocating P-type atpase
RPIT_RS07250	COG1937	Protein conserved in bacteria
RPIT_RS07275	COG3507	Belongs to the glycosyl hydrolase 43 family
RPIT_RS07280	COG3507	Belongs to the glycosyl hydrolase 43 family
RPIT_RS07285	COG1609	Transcriptional regulator
RPIT_RS07380	COG1201	RNA secondary structure unwinding
RPIT_RS07410	COG0366	Alpha amylase catalytic
RPIT_RS07425	COG3547	Transposase (IS116 IS110 IS902 family)
RPIT_RS07455	COG3547	Transposase (IS116 IS110 IS902 family)
RPIT_RS07530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RPIT_RS07620	COG1120	ATPase activity
RPIT_RS07640	COG1309	transcriptional regulator
RPIT_RS07660	COG0427	acetyl-CoA hydrolase
RPIT_RS07665	COG3655	Transcriptional regulator
RPIT_RS07700	COG0823	Involved in the tonB-independent uptake of proteins
RPIT_RS07700	COG1506	peptidase
RPIT_RS07715	COG0693	protein deglycase activity
RPIT_RS07730	COG2197	response regulator
RPIT_RS07770	COG0515	serine threonine protein kinase
RPIT_RS07800	COG0515	serine threonine protein kinase
RPIT_RS07815	COG1742	UPF0060 membrane protein
RPIT_RS07830	COG0066	3-isopropylmalate dehydratase activity
RPIT_RS07835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RPIT_RS07840	COG1414	Transcriptional regulator
RPIT_RS07860	COG1266	CAAX protease self-immunity
RPIT_RS07865	COG0179	Fumarylacetoacetate (FAA) hydrolase
RPIT_RS07870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RPIT_RS07875	COG0473	3-isopropylmalate dehydrogenase activity
RPIT_RS07880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RPIT_RS07885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RPIT_RS07890	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RPIT_RS07895	COG0440	acetolactate synthase activity
RPIT_RS07915	COG0107	imidazoleglycerol-phosphate synthase activity
RPIT_RS07935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RPIT_RS07950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPIT_RS07955	COG0545	Peptidyl-prolyl cis-trans isomerase
RPIT_RS07965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RPIT_RS08005	COG0504	CTP synthase activity
RPIT_RS08015	COG0497	DNA recombination
RPIT_RS08020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RPIT_RS08075	COG1595	DNA-templated transcription, initiation
RPIT_RS08115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RPIT_RS08125	COG0165	Argininosuccinate lyase
RPIT_RS08140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RPIT_RS08145	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RPIT_RS08150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RPIT_RS08170	COG2124	cytochrome p450
RPIT_RS08185	COG0072	phenylalanine-tRNA ligase activity
RPIT_RS08185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RPIT_RS08190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RPIT_RS08195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RPIT_RS08200	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RPIT_RS08205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RPIT_RS08210	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RPIT_RS08230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RPIT_RS08235	COG0140	phosphoribosyl-ATP diphosphatase activity
RPIT_RS08240	COG0215	cysteine-tRNA ligase activity
RPIT_RS08260	COG1968	undecaprenyl-diphosphatase activity
RPIT_RS08265	COG0667	Aldo Keto reductase
RPIT_RS08305	COG0582	viral genome integration into host DNA
RPIT_RS08340	COG0537	adenosine 5'-monophosphoramidase activity
RPIT_RS08345	COG2132	Multicopper oxidase
RPIT_RS08355	COG0745	RESPONSE REGULATOR receiver
RPIT_RS08360	COG2205	protein histidine kinase activity
RPIT_RS08365	COG2217	Heavy metal translocating P-type atpase
RPIT_RS08380	COG0577	efflux transmembrane transporter activity
RPIT_RS08380	COG1136	(ABC) transporter
RPIT_RS08410	COG0133	tryptophan synthase activity
RPIT_RS08415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RPIT_RS08435	COG3845	ABC transporter
RPIT_RS08465	COG0792	nuclease activity
RPIT_RS08475	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RPIT_RS08485	COG0335	large ribosomal subunit rRNA binding
RPIT_RS08490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RPIT_RS08495	COG1053	succinate dehydrogenase
RPIT_RS08505	COG0336	Belongs to the RNA methyltransferase TrmD family
RPIT_RS08510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RPIT_RS08515	COG1837	Belongs to the UPF0109 family
RPIT_RS08520	COG0228	four-way junction DNA binding
RPIT_RS08560	COG2197	response regulator
RPIT_RS08580	COG1132	(ABC) transporter
RPIT_RS08600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RPIT_RS08605	COG0571	ribonuclease III activity
RPIT_RS08610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RPIT_RS08620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RPIT_RS08625	COG0742	ribosomal rna small subunit methyltransferase
RPIT_RS08630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RPIT_RS08645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RPIT_RS08650	COG1530	ribonuclease E activity
RPIT_RS08660	COG2807	transmembrane transport
RPIT_RS08665	COG4868	Belongs to the UPF0371 family
RPIT_RS08670	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIT_RS08670	COG0596	Alpha beta hydrolase
RPIT_RS08675	COG1254	Belongs to the acylphosphatase family
RPIT_RS08685	COG0105	UTP biosynthetic process
RPIT_RS08695	COG0285	dihydrofolate synthase activity
RPIT_RS08705	COG0525	valine-tRNA ligase activity
RPIT_RS08710	COG0793	Belongs to the peptidase S41A family
RPIT_RS08710	COG4946	Tricorn protease homolog
RPIT_RS08720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RPIT_RS08725	COG0740	serine-type endopeptidase activity
RPIT_RS08730	COG0740	serine-type endopeptidase activity
RPIT_RS08735	COG0628	permease
RPIT_RS08740	COG0544	peptidyl-prolyl cis-trans isomerase activity
RPIT_RS08770	COG0366	Alpha amylase catalytic
RPIT_RS08775	COG0395	ABC-type sugar transport system, permease component
RPIT_RS08780	COG1175	transmembrane transport
RPIT_RS08795	COG1940	carbohydrate kinase activity
RPIT_RS08800	COG2066	Belongs to the glutaminase family
RPIT_RS08820	COG1063	alcohol dehydrogenase
RPIT_RS08840	COG4552	Acetyltransferase involved in intracellular survival and related
RPIT_RS08845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RPIT_RS08860	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RPIT_RS08865	COG0540	Belongs to the ATCase OTCase family
RPIT_RS08870	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RPIT_RS08875	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RPIT_RS08880	COG1201	RNA secondary structure unwinding
RPIT_RS08885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RPIT_RS08890	COG1609	Transcriptional regulator
RPIT_RS08895	COG2160	L-arabinose isomerase activity
RPIT_RS08920	COG0277	FAD linked oxidase domain protein
RPIT_RS08925	COG1595	DNA-templated transcription, initiation
RPIT_RS08980	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RPIT_RS09025	COG1469	GTP cyclohydrolase I activity
RPIT_RS09080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RPIT_RS09085	COG0667	Aldo Keto reductase
RPIT_RS09100	COG0084	hydrolase, TatD family'
RPIT_RS09105	COG3588	fructose-bisphosphate aldolase
RPIT_RS09110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPIT_RS09125	COG3118	belongs to the thioredoxin family
RPIT_RS09130	COG2323	membrane
RPIT_RS09205	COG1216	Glycosyl transferase, family 2
RPIT_RS09215	COG0438	transferase activity, transferring glycosyl groups
RPIT_RS09250	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RPIT_RS09325	COG1739	Uncharacterized protein family UPF0029
RPIT_RS09335	COG1595	DNA-templated transcription, initiation
RPIT_RS09380	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RPIT_RS09395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RPIT_RS09400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RPIT_RS09405	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RPIT_RS09410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RPIT_RS09420	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RPIT_RS09450	COG2814	Major facilitator Superfamily
RPIT_RS09465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RPIT_RS09475	COG2835	tetraacyldisaccharide 4'-kinase activity
RPIT_RS09530	COG1316	TRANSCRIPTIONal
RPIT_RS09535	COG1316	TRANSCRIPTIONal
RPIT_RS09560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RPIT_RS09570	COG0424	maF-like protein
RPIT_RS09590	COG4770	biotin carboxylase activity
RPIT_RS09600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RPIT_RS09615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RPIT_RS09635	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RPIT_RS09640	COG0328	RNA-DNA hybrid ribonuclease activity
RPIT_RS09645	COG2197	response regulator
RPIT_RS09660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RPIT_RS09675	COG1079	Belongs to the binding-protein-dependent transport system permease family
RPIT_RS09680	COG4603	Belongs to the binding-protein-dependent transport system permease family
RPIT_RS09685	COG3845	ABC transporter
RPIT_RS09690	COG1744	ABC transporter substrate-binding protein PnrA-like
RPIT_RS09705	COG1253	flavin adenine dinucleotide binding
RPIT_RS09720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RPIT_RS09725	COG0039	L-malate dehydrogenase activity
RPIT_RS09745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RPIT_RS09750	COG0138	bifunctional purine biosynthesis protein purh
RPIT_RS09775	COG0045	succinate-CoA ligase (ADP-forming) activity
RPIT_RS09790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RPIT_RS09805	COG2197	response regulator
RPIT_RS09830	COG0519	Catalyzes the synthesis of GMP from XMP
RPIT_RS09830	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RPIT_RS09850	COG1605	Chorismate mutase
RPIT_RS09850	COG0287	Prephenate dehydrogenase
RPIT_RS09855	COG0516	GMP reductase activity
RPIT_RS09870	COG0459	protein refolding
RPIT_RS09875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RPIT_RS09880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RPIT_RS09885	COG0110	maltose O-acetyltransferase activity
RPIT_RS09895	COG1984	allophanate hydrolase subunit 2
RPIT_RS09900	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RPIT_RS09905	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RPIT_RS09935	COG0601	transmembrane transport
RPIT_RS09940	COG0747	negative chemotaxis
RPIT_RS09945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RPIT_RS09950	COG0456	acetyltransferase
RPIT_RS09960	COG0802	atpase or kinase
RPIT_RS09965	COG0513	Belongs to the DEAD box helicase family
RPIT_RS09975	COG2847	Copper chaperone PCu(A)C
RPIT_RS09990	COG0736	holo-[acyl-carrier-protein] synthase activity
RPIT_RS09995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RPIT_RS10000	COG1072	(Pantothenic acid kinase))
RPIT_RS10005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPIT_RS10010	COG0006	proline dipeptidase activity
RPIT_RS10020	COG2264	protein methyltransferase activity
RPIT_RS10030	COG2239	Acts as a magnesium transporter
RPIT_RS10050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RPIT_RS10065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RPIT_RS10075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RPIT_RS10080	COG0297	glycogen (starch) synthase activity
RPIT_RS10095	COG1611	Belongs to the LOG family
RPIT_RS10100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPIT_RS10105	COG1305	Transglutaminase-like
RPIT_RS10120	COG1054	Belongs to the UPF0176 family
RPIT_RS10125	COG2171	N-acyltransferase activity
RPIT_RS10140	COG1132	(ABC) transporter
RPIT_RS10145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RPIT_RS10155	COG5016	pyruvate
RPIT_RS10155	COG0511	ligase activity, forming carbon-carbon bonds
RPIT_RS10180	COG0616	signal peptide processing
RPIT_RS10225	COG1335	isochorismatase
RPIT_RS10230	COG3263	regulation of cellular component size
RPIT_RS10245	COG1045	serine acetyltransferase
RPIT_RS10250	COG1131	(ABC) transporter
RPIT_RS10270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RPIT_RS10285	COG0259	pyridoxamine-phosphate oxidase activity
RPIT_RS10310	COG0596	Alpha beta hydrolase
RPIT_RS10315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RPIT_RS10350	COG0745	RESPONSE REGULATOR receiver
RPIT_RS10365	COG0012	GTP binding
RPIT_RS10370	COG4607	ABC-type enterochelin transport system periplasmic component
RPIT_RS10375	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RPIT_RS10380	COG4605	iron ion homeostasis
RPIT_RS10385	COG4604	ABC transporter, ATP-binding protein
RPIT_RS10395	COG1362	aminopeptidase activity
RPIT_RS10400	COG1322	Protein conserved in bacteria
RPIT_RS10405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RPIT_RS10410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RPIT_RS10420	COG1570	exodeoxyribonuclease VII activity
RPIT_RS10425	COG1722	exodeoxyribonuclease VII activity
RPIT_RS10435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RPIT_RS10445	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RPIT_RS10450	COG1331	Highly conserved protein containing a thioredoxin domain
RPIT_RS10460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RPIT_RS10470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RPIT_RS10485	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RPIT_RS10510	COG0667	Aldo Keto reductase
RPIT_RS10555	COG2268	Band 7 protein
RPIT_RS10605	COG0148	phosphopyruvate hydratase activity
RPIT_RS10625	COG0193	aminoacyl-tRNA hydrolase activity
RPIT_RS10630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RPIT_RS10640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RPIT_RS10645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RPIT_RS10655	COG0745	RESPONSE REGULATOR receiver
RPIT_RS10680	COG1595	DNA-templated transcription, initiation
RPIT_RS10730	COG0243	molybdopterin cofactor binding
RPIT_RS10740	COG3302	dmso reductase anchor subunit
RPIT_RS10760	COG1715	Restriction endonuclease
RPIT_RS10765	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
RPIT_RS10795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RPIT_RS10800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RPIT_RS10805	COG0243	molybdopterin cofactor binding
RPIT_RS10810	COG2223	nitrite transmembrane transporter activity
RPIT_RS10830	COG2818	Glycosylase
RPIT_RS10845	COG1846	Transcriptional regulator
RPIT_RS10850	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RPIT_RS10855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RPIT_RS10860	COG0084	hydrolase, TatD family'
RPIT_RS10885	COG1136	(ABC) transporter
RPIT_RS10905	COG2233	PERMEase
RPIT_RS10910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RPIT_RS10935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RPIT_RS10950	COG1970	mechanosensitive ion channel activity
RPIT_RS10995	COG0167	dihydroorotate dehydrogenase activity
RPIT_RS11000	COG1013	pyruvate-flavodoxin oxidoreductase activity
RPIT_RS11000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RPIT_RS11000	COG0674	pyruvate-flavodoxin oxidoreductase activity
RPIT_RS11000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RPIT_RS11005	COG0493	'glutamate synthase
RPIT_RS11010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RPIT_RS11030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RPIT_RS11045	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RPIT_RS11055	COG2252	PERMEase
RPIT_RS11070	COG1278	Cold shock
RPIT_RS11075	COG0363	glucosamine-6-phosphate deaminase activity
RPIT_RS11085	COG1051	belongs to the nudix hydrolase family
RPIT_RS11145	COG0626	cystathionine gamma-synthase activity
RPIT_RS11165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
RPIT_RS11170	COG0215	cysteine-tRNA ligase activity
RPIT_RS11180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RPIT_RS11195	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RPIT_RS11200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RPIT_RS11205	COG1329	Transcriptional regulator
RPIT_RS11220	COG5002	protein histidine kinase activity
RPIT_RS11230	COG0588	phosphoglycerate mutase activity
RPIT_RS11235	COG0588	phosphoglycerate mutase activity
RPIT_RS11240	COG0628	permease
RPIT_RS11255	COG1454	alcohol dehydrogenase
RPIT_RS11285	COG3458	cephalosporin-C deacetylase activity
RPIT_RS11290	COG1472	Belongs to the glycosyl hydrolase 3 family
RPIT_RS11300	COG1175	transmembrane transport
RPIT_RS11305	COG0395	ABC-type sugar transport system, permease component
RPIT_RS11310	COG1609	Transcriptional regulator
RPIT_RS11320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RPIT_RS11335	COG0022	dehydrogenase e1 component
RPIT_RS11340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RPIT_RS11345	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIT_RS11350	COG1349	DNA-binding transcription factor activity
RPIT_RS11360	COG0702	epimerase
RPIT_RS11370	COG1073	alpha beta
RPIT_RS11390	COG1070	Carbohydrate kinase
RPIT_RS11400	COG1609	Transcriptional regulator
RPIT_RS11405	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIT_RS11425	COG1595	DNA-templated transcription, initiation
RPIT_RS11460	COG0191	fructose-bisphosphate aldolase activity
RPIT_RS11495	COG1704	LemA family
RPIT_RS11500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RPIT_RS11510	COG0728	peptidoglycan biosynthetic process
RPIT_RS11535	COG1621	beta-fructofuranosidase activity
RPIT_RS11545	COG0395	ABC-type sugar transport system, permease component
RPIT_RS11550	COG4209	transmembrane transport
RPIT_RS11560	COG0723	plastoquinol--plastocyanin reductase activity
RPIT_RS11560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPIT_RS11565	COG1482	cell wall glycoprotein biosynthetic process
RPIT_RS11575	COG0395	ABC-type sugar transport system, permease component
RPIT_RS11585	COG1653	transport
RPIT_RS11595	COG1609	Transcriptional regulator
RPIT_RS11615	COG0668	transmembrane transport
RPIT_RS11620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RPIT_RS11625	COG1125	glycine betaine transport
RPIT_RS11625	COG0517	IMP dehydrogenase activity
RPIT_RS11630	COG1174	glycine betaine transport
RPIT_RS11635	COG1174	glycine betaine transport
RPIT_RS11645	COG4175	Glycine betaine
RPIT_RS11645	COG0517	IMP dehydrogenase activity
RPIT_RS11680	COG0534	Mate efflux family protein
RPIT_RS11685	COG2133	pyrroloquinoline quinone binding
RPIT_RS11695	COG0259	pyridoxamine-phosphate oxidase activity
RPIT_RS11700	COG0222	ribosome binding
RPIT_RS11705	COG0542	response to heat
RPIT_RS11710	COG0366	Alpha amylase catalytic
RPIT_RS11730	COG1472	Belongs to the glycosyl hydrolase 3 family
RPIT_RS11745	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RPIT_RS11745	COG0352	thiamine-phosphate diphosphorylase activity
RPIT_RS11745	COG0351	phosphomethylpyrimidine kinase
RPIT_RS11750	COG0351	phosphomethylpyrimidine kinase
RPIT_RS11755	COG0352	thiamine-phosphate diphosphorylase activity
RPIT_RS11755	COG0351	phosphomethylpyrimidine kinase
RPIT_RS11755	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RPIT_RS11760	COG0428	transporter
RPIT_RS11780	COG0058	SHG alpha-glucan phosphorylase activity
RPIT_RS11785	COG2815	serine threonine protein kinase
RPIT_RS11785	COG0515	serine threonine protein kinase
RPIT_RS11790	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RPIT_RS11795	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RPIT_RS11815	COG0789	Transcriptional regulator
RPIT_RS11820	COG0484	heat shock protein binding
RPIT_RS11825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RPIT_RS11855	COG1175	transmembrane transport
RPIT_RS11860	COG0395	ABC-type sugar transport system, permease component
RPIT_RS11880	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIT_RS11890	COG1940	carbohydrate kinase activity
RPIT_RS11895	COG1129	ABC transporter
RPIT_RS11900	COG1609	Transcriptional regulator
RPIT_RS11905	COG1621	beta-fructofuranosidase activity
RPIT_RS11910	COG1819	glycosyl
RPIT_RS11930	COG0189	ligase activity
RPIT_RS11950	COG1100	Small GTP-binding protein
RPIT_RS12005	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RPIT_RS12030	COG1252	NADH dehydrogenase
RPIT_RS12035	COG2259	Doxx family
RPIT_RS12040	COG0745	RESPONSE REGULATOR receiver
RPIT_RS12045	COG2205	protein histidine kinase activity
RPIT_RS12065	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RPIT_RS12070	COG1132	(ABC) transporter
RPIT_RS12085	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RPIT_RS12090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RPIT_RS12105	COG3132	Protein of unknown function, DUF480
RPIT_RS12115	COG1653	transport
RPIT_RS12120	COG0433	COG0433 Predicted ATPase
RPIT_RS12155	COG0590	tRNA wobble adenosine to inosine editing
RPIT_RS12165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RPIT_RS12175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RPIT_RS12180	COG0584	glycerophosphoryl diester phosphodiesterase
RPIT_RS12195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RPIT_RS12205	COG1316	TRANSCRIPTIONal
RPIT_RS12225	COG0564	pseudouridine synthase activity
RPIT_RS12255	COG0477	Major facilitator Superfamily
RPIT_RS12260	COG1316	TRANSCRIPTIONal
RPIT_RS12285	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
RPIT_RS12290	COG1940	carbohydrate kinase activity
RPIT_RS12295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RPIT_RS12305	COG0444	Belongs to the ABC transporter superfamily
RPIT_RS12315	COG0747	negative chemotaxis
RPIT_RS12320	COG2186	Transcriptional regulator
RPIT_RS12330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RPIT_RS12335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RPIT_RS12345	COG2205	protein histidine kinase activity
RPIT_RS12350	COG0745	RESPONSE REGULATOR receiver
RPIT_RS12375	COG3402	PFAM membrane-flanked domain
RPIT_RS12385	COG1131	(ABC) transporter
RPIT_RS12405	COG3265	gluconokinase activity
RPIT_RS12410	COG0438	transferase activity, transferring glycosyl groups
RPIT_RS12425	COG1950	PFAM Membrane protein of
RPIT_RS12465	COG1309	transcriptional regulator
RPIT_RS12470	COG1131	(ABC) transporter
RPIT_RS12475	COG3559	Exporter of polyketide antibiotics
RPIT_RS12505	COG4585	Histidine kinase
RPIT_RS12510	COG2197	response regulator
RPIT_RS12520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPIT_RS12530	COG0590	tRNA wobble adenosine to inosine editing
RPIT_RS12535	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RPIT_RS12540	COG1088	dTDP-glucose 4,6-dehydratase activity
RPIT_RS12575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RPIT_RS12580	COG1716	ATPase activity
RPIT_RS12600	COG0768	penicillin binding
RPIT_RS12605	COG0515	serine threonine protein kinase
RPIT_RS12650	COG2723	6-phospho-beta-galactosidase activity
RPIT_RS12670	COG1396	sequence-specific DNA binding
RPIT_RS12680	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RPIT_RS12685	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RPIT_RS12695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RPIT_RS12705	COG0662	Cupin 2, conserved barrel domain protein
RPIT_RS12725	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIT_RS12730	COG1129	ABC transporter
RPIT_RS12755	COG0246	Mannitol dehydrogenase
RPIT_RS12775	COG3012	SEC-C Motif Domain Protein
RPIT_RS12800	COG2514	catechol 2,3-dioxygenase activity
RPIT_RS12805	COG2326	polyphosphate kinase activity
RPIT_RS12815	COG1271	oxidase subunit
RPIT_RS12820	COG1294	oxidase, subunit
RPIT_RS12825	COG4988	ABC transporter
RPIT_RS12840	COG0114	fumarate hydratase activity
RPIT_RS12855	COG1937	Protein conserved in bacteria
RPIT_RS12860	COG0305	Participates in initiation and elongation during chromosome replication
RPIT_RS12880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RPIT_RS12885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RPIT_RS12915	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RPIT_RS12920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RPIT_RS12925	COG0686	Belongs to the AlaDH PNT family
RPIT_RS12945	COG1597	lipid kinase activity
RPIT_RS12960	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
RPIT_RS12980	COG2348	transferase activity, transferring amino-acyl groups
RPIT_RS12995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RPIT_RS13000	COG0668	transmembrane transport
RPIT_RS13005	COG0617	tRNA 3'-terminal CCA addition
RPIT_RS13015	COG0515	serine threonine protein kinase
RPIT_RS13015	COG2815	serine threonine protein kinase
RPIT_RS13035	COG1793	dna ligase
RPIT_RS13040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RPIT_RS13045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RPIT_RS13055	COG2409	Drug exporters of the RND superfamily
RPIT_RS13070	COG3693	PFAM glycoside hydrolase, family 10
RPIT_RS13095	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
RPIT_RS13100	COG0789	Transcriptional regulator
RPIT_RS13130	COG2076	Multidrug Resistance protein
RPIT_RS13135	COG2985	domain, Protein
RPIT_RS13135	COG0569	domain protein
RPIT_RS13140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIT_RS13145	COG3655	Transcriptional regulator
RPIT_RS13155	COG1609	Transcriptional regulator
RPIT_RS13170	COG1070	Carbohydrate kinase
RPIT_RS13175	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIT_RS13180	COG1129	ABC transporter
RPIT_RS13185	COG2188	Transcriptional regulator
RPIT_RS13190	COG0159	tryptophan synthase activity
RPIT_RS13225	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
RPIT_RS13230	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RPIT_RS13245	COG0577	efflux transmembrane transporter activity
RPIT_RS13245	COG1136	(ABC) transporter
RPIT_RS13275	COG2354	Protein conserved in bacteria
RPIT_RS13280	COG0667	Aldo Keto reductase
RPIT_RS13285	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_RS13295	COG2409	Drug exporters of the RND superfamily
RPIT_RS13315	COG1902	pentaerythritol trinitrate reductase activity
RPIT_RS13365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RPIT_RS13390	COG2132	Multicopper oxidase
RPIT_RS13410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RPIT_RS13415	COG2390	Transcriptional regulator
RPIT_RS13420	COG1024	Enoyl-CoA hydratase
RPIT_RS13430	COG0492	ferredoxin-NADP+ reductase activity
RPIT_RS13435	COG3118	belongs to the thioredoxin family
RPIT_RS13445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPIT_RS13450	COG1181	Belongs to the D-alanine--D-alanine ligase family
RPIT_RS13475	COG0357	Ribosomal RNA small subunit methyltransferase G
RPIT_RS13485	COG0706	membrane insertase activity
RPIT_RS13490	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RPIT_RS13500	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RPIT_RS13505	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RPIT_RS13510	COG1937	Protein conserved in bacteria
RPIT_RS13520	COG0446	pyridine nucleotide-disulphide oxidoreductase
RPIT_RS13525	COG1136	(ABC) transporter
RPIT_RS13535	COG0592	DNA-directed DNA polymerase activity
RPIT_RS13540	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
RPIT_RS13545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RPIT_RS13555	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
RPIT_RS13570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RPIT_RS13575	COG3266	domain, Protein
RPIT_RS13585	COG3177	Filamentation induced by cAMP protein fic
RPIT_RS13600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RPIT_RS13610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RPIT_RS13620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RPIT_RS13650	COG0457	Tetratricopeptide repeat
RPIT_RS13650	COG0705	Rhomboid family
RPIT_RS13660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RPIT_RS13665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RPIT_RS13685	COG0489	protein tyrosine kinase activity
RPIT_RS13695	COG0726	polysaccharide deacetylase
RPIT_RS13705	COG0438	transferase activity, transferring glycosyl groups
RPIT_RS13735	COG1216	Glycosyl transferase, family 2
RPIT_RS13740	COG1215	transferase activity, transferring glycosyl groups
RPIT_RS13755	COG1215	transferase activity, transferring glycosyl groups
RPIT_RS13760	COG1216	Glycosyl transferase, family 2
RPIT_RS13770	COG3958	Transketolase
RPIT_RS13775	COG3959	Transketolase, thiamine diphosphate binding domain
RPIT_RS13780	COG0667	Aldo Keto reductase
RPIT_RS13785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RPIT_RS13805	COG1569	PIN domain
RPIT_RS13810	COG1216	Glycosyl transferase, family 2
RPIT_RS13815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RPIT_RS13885	COG1215	transferase activity, transferring glycosyl groups
RPIT_RS13905	COG1132	(ABC) transporter
RPIT_RS13920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RPIT_RS13940	COG1215	transferase activity, transferring glycosyl groups
RPIT_RS13950	COG1086	Polysaccharide biosynthesis protein
RPIT_RS13965	COG1115	amino acid carrier protein
RPIT_RS13970	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RPIT_RS13970	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RPIT_RS13985	COG0745	RESPONSE REGULATOR receiver
RPIT_RS13990	COG5002	protein histidine kinase activity
RPIT_RS13995	COG0439	Biotin carboxylase
RPIT_RS14015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPIT_RS14030	COG1132	(ABC) transporter
RPIT_RS14040	COG2059	Chromate
RPIT_RS14060	COG0535	radical SAM domain protein
RPIT_RS14065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RPIT_RS14070	COG0431	NADPH-dependent FMN reductase
RPIT_RS14075	COG1760	l-serine dehydratase
RPIT_RS14135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RPIT_RS14160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RPIT_RS14205	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RPIT_RS14225	COG0574	Belongs to the PEP-utilizing enzyme family
RPIT_RS14225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RPIT_RS14250	COG0733	neurotransmitter:sodium symporter activity
RPIT_RS14255	COG3022	response to hydroperoxide
RPIT_RS14280	COG4221	oxidoreductase activity
RPIT_RS14295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RPIT_RS14315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIT_RS14320	COG1320	monovalent cation:proton antiporter activity
RPIT_RS14330	COG1863	multisubunit Na H antiporter MnhE subunit
RPIT_RS14335	COG0651	ATP synthesis coupled electron transport
RPIT_RS14340	COG1006	Multisubunit Na H antiporter MnhC subunit
RPIT_RS14345	COG2111	Na H antiporter
RPIT_RS14345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RPIT_RS14355	COG1022	Amp-dependent synthetase and ligase
RPIT_RS14365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RPIT_RS14375	COG0360	Binds together with S18 to 16S ribosomal RNA
RPIT_RS14385	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RPIT_RS14390	COG0359	binds to the 23S rRNA
RPIT_RS14395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RPIT_RS14415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RPIT_RS14420	COG3592	Divergent 4Fe-4S mono-cluster
RPIT_RS14440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RPIT_RS14440	COG4651	solute:proton antiporter activity
RPIT_RS14445	COG1028	Short-chain dehydrogenase reductase Sdr
RPIT_RS14455	COG0530	calcium, potassium:sodium antiporter activity
RPIT_RS14470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RPIT_RS14505	COG1192	Involved in chromosome partitioning
RPIT_RS14520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RPIT_RS14525	COG3328	transposase activity
RPIT_RS14560	COG1506	peptidase
RPIT_RS14560	COG0823	Involved in the tonB-independent uptake of proteins
RPIT_RS14580	COG0747	negative chemotaxis
RPIT_RS14590	COG4608	Belongs to the ABC transporter superfamily
RPIT_RS14595	COG0444	Belongs to the ABC transporter superfamily
RPIT_RS14600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RPIT_RS14605	COG0601	transmembrane transport
RPIT_RS14610	COG4166	transmembrane transport
RPIT_RS14615	COG1070	Carbohydrate kinase
RPIT_RS14625	COG0640	Transcriptional regulator
RPIT_RS14655	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RPIT_RS14680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RPIT_RS14745	COG2920	part of a sulfur-relay system
RPIT_RS14750	COG0446	pyridine nucleotide-disulphide oxidoreductase