locus-tag	class	description
KDB89_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KDB89_RS00020	COG0577	efflux transmembrane transporter activity
KDB89_RS00025	COG0592	DNA-directed DNA polymerase activity
KDB89_RS00040	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
KDB89_RS00055	COG0739	heme binding
KDB89_RS00055	COG0741	lytic transglycosylase activity
KDB89_RS00055	COG1196	nuclear chromosome segregation
KDB89_RS00075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KDB89_RS00090	COG3654	unkown
KDB89_RS00100	COG1569	PIN domain
KDB89_RS00105	COG3848	Pyruvate phosphate dikinase
KDB89_RS00105	COG0574	Belongs to the PEP-utilizing enzyme family
KDB89_RS00160	COG1316	TRANSCRIPTIONal
KDB89_RS00170	COG0489	protein tyrosine kinase activity
KDB89_RS00200	COG2089	acid synthase
KDB89_RS00240	COG1132	(ABC) transporter
KDB89_RS00260	COG2354	Protein conserved in bacteria
KDB89_RS00275	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KDB89_RS00330	COG2197	response regulator
KDB89_RS00335	COG4585	Histidine kinase
KDB89_RS00355	COG1129	ABC transporter
KDB89_RS00360	COG1172	Belongs to the binding-protein-dependent transport system permease family
KDB89_RS00365	COG1172	Belongs to the binding-protein-dependent transport system permease family
KDB89_RS00385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KDB89_RS00395	COG2409	Drug exporters of the RND superfamily
KDB89_RS00430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KDB89_RS00435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KDB89_RS00445	COG1116	anion transmembrane transporter activity
KDB89_RS00460	COG1793	dna ligase
KDB89_RS00465	COG0442	prolyl-tRNA aminoacylation
KDB89_RS00490	COG3265	gluconokinase activity
KDB89_RS00500	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KDB89_RS00510	COG1105	Belongs to the carbohydrate kinase PfkB family
KDB89_RS00515	COG0617	tRNA 3'-terminal CCA addition
KDB89_RS00520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KDB89_RS00525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KDB89_RS00535	COG2197	response regulator
KDB89_RS00545	COG1136	(ABC) transporter
KDB89_RS00605	COG4942	peptidase
KDB89_RS00610	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KDB89_RS00620	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KDB89_RS00625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KDB89_RS00625	COG0574	Belongs to the PEP-utilizing enzyme family
KDB89_RS00645	COG3022	response to hydroperoxide
KDB89_RS00660	COG1028	Short-chain dehydrogenase reductase Sdr
KDB89_RS00665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KDB89_RS00680	COG1320	monovalent cation:proton antiporter activity
KDB89_RS00695	COG0651	ATP synthesis coupled electron transport
KDB89_RS00700	COG1006	Multisubunit Na H antiporter MnhC subunit
KDB89_RS00705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KDB89_RS00705	COG2111	Na H antiporter
KDB89_RS00735	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
KDB89_RS00740	COG0488	(ABC) transporter
KDB89_RS00765	COG0360	Binds together with S18 to 16S ribosomal RNA
KDB89_RS00775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KDB89_RS00780	COG0359	binds to the 23S rRNA
KDB89_RS00805	COG1760	l-serine dehydratase
KDB89_RS00815	COG1846	Transcriptional regulator
KDB89_RS00835	COG0662	Cupin 2, conserved barrel domain protein
KDB89_RS00840	COG0028	Belongs to the TPP enzyme family
KDB89_RS00850	COG1028	Short-chain dehydrogenase reductase Sdr
KDB89_RS00870	COG2390	Transcriptional regulator
KDB89_RS00875	COG1132	(ABC) transporter
KDB89_RS00890	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KDB89_RS00905	COG2814	Major facilitator Superfamily
KDB89_RS00945	COG1940	carbohydrate kinase activity
KDB89_RS00960	COG0673	inositol 2-dehydrogenase activity
KDB89_RS00965	COG2211	Major facilitator Superfamily
KDB89_RS00970	COG1940	carbohydrate kinase activity
KDB89_RS00995	COG1203	CRISPR-associated helicase, Cas3
KDB89_RS01005	COG1518	maintenance of DNA repeat elements
KDB89_RS01005	COG1468	defense response to virus
KDB89_RS01015	COG2205	protein histidine kinase activity
KDB89_RS01030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KDB89_RS01050	COG1216	Glycosyl transferase, family 2
KDB89_RS01055	COG1215	transferase activity, transferring glycosyl groups
KDB89_RS01070	COG0022	dehydrogenase e1 component
KDB89_RS01075	COG0508	dehydrogenase complex catalyzes the overall conversion of
KDB89_RS01080	COG0456	acetyltransferase
KDB89_RS01090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KDB89_RS01100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KDB89_RS01105	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KDB89_RS01110	COG5006	permease, DMT superfamily
KDB89_RS01145	COG1674	ftsk spoiiie
KDB89_RS01150	COG1404	Belongs to the peptidase S8 family
KDB89_RS01155	COG0077	Prephenate dehydratase
KDB89_RS01170	COG2814	Major facilitator Superfamily
KDB89_RS01175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KDB89_RS01180	COG1482	cell wall glycoprotein biosynthetic process
KDB89_RS01185	COG0561	phosphatase activity
KDB89_RS01195	COG0137	argininosuccinate synthase activity
KDB89_RS01205	COG1134	teichoic acid transport
KDB89_RS01220	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KDB89_RS01245	COG0673	inositol 2-dehydrogenase activity
KDB89_RS01260	COG1215	transferase activity, transferring glycosyl groups
KDB89_RS01275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KDB89_RS01280	COG0564	pseudouridine synthase activity
KDB89_RS01295	COG1316	TRANSCRIPTIONal
KDB89_RS01360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KDB89_RS01375	COG0584	glycerophosphoryl diester phosphodiesterase
KDB89_RS01380	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KDB89_RS01430	COG4585	Histidine kinase
KDB89_RS01435	COG2197	response regulator
KDB89_RS01470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KDB89_RS01505	COG0433	COG0433 Predicted ATPase
KDB89_RS01515	COG1653	transport
KDB89_RS01545	COG3328	transposase activity
KDB89_RS01550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KDB89_RS01555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KDB89_RS01560	COG0747	negative chemotaxis
KDB89_RS01570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KDB89_RS01575	COG4172	Belongs to the ABC transporter superfamily
KDB89_RS01580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KDB89_RS01605	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KDB89_RS01630	COG0714	Associated with various cellular activities
KDB89_RS01650	COG0717	Belongs to the dCTP deaminase family
KDB89_RS01655	COG1132	(ABC) transporter
KDB89_RS01660	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KDB89_RS01665	COG1470	cell adhesion involved in biofilm formation
KDB89_RS01665	COG0366	Alpha amylase catalytic
KDB89_RS01670	COG3328	transposase activity
KDB89_RS01675	COG2205	protein histidine kinase activity
KDB89_RS01680	COG0745	RESPONSE REGULATOR receiver
KDB89_RS01685	COG2259	Doxx family
KDB89_RS01690	COG1252	NADH dehydrogenase
KDB89_RS01710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KDB89_RS01720	COG1316	TRANSCRIPTIONal
KDB89_RS01750	COG0484	heat shock protein binding
KDB89_RS01755	COG0789	Transcriptional regulator
KDB89_RS01770	COG1733	regulation of RNA biosynthetic process
KDB89_RS01775	COG0702	epimerase
KDB89_RS01815	COG1454	alcohol dehydrogenase
KDB89_RS01830	COG3328	transposase activity
KDB89_RS01835	COG0058	SHG alpha-glucan phosphorylase activity
KDB89_RS01840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KDB89_RS01845	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KDB89_RS01850	COG1120	ATPase activity
KDB89_RS01865	COG1012	belongs to the aldehyde dehydrogenase family
KDB89_RS01865	COG1454	alcohol dehydrogenase
KDB89_RS01930	COG4869	propanediol catabolic process
KDB89_RS01935	COG0849	cell division
KDB89_RS01945	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
KDB89_RS01955	COG1012	belongs to the aldehyde dehydrogenase family
KDB89_RS01960	COG0039	L-malate dehydrogenase activity
KDB89_RS01980	COG1285	pathogenesis
KDB89_RS01990	COG0542	response to heat
KDB89_RS02010	COG0259	pyridoxamine-phosphate oxidase activity
KDB89_RS02015	COG2133	pyrroloquinoline quinone binding
KDB89_RS02020	COG0534	Mate efflux family protein
KDB89_RS02040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KDB89_RS02045	COG1704	LemA family
KDB89_RS02070	COG0191	fructose-bisphosphate aldolase activity
KDB89_RS02075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KDB89_RS02085	COG0640	Transcriptional regulator
KDB89_RS02090	COG2217	Heavy metal translocating P-type atpase
KDB89_RS02100	COG1172	Belongs to the binding-protein-dependent transport system permease family
KDB89_RS02110	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
KDB89_RS02120	COG1609	Transcriptional regulator
KDB89_RS02140	COG4213	ABC transporter substrate-binding protein
KDB89_RS02145	COG1172	Belongs to the binding-protein-dependent transport system permease family
KDB89_RS02150	COG1129	ABC transporter
KDB89_RS02160	COG1129	ABC transporter
KDB89_RS02175	COG0577	efflux transmembrane transporter activity
KDB89_RS02175	COG1136	(ABC) transporter
KDB89_RS02180	COG0577	efflux transmembrane transporter activity
KDB89_RS02180	COG1136	(ABC) transporter
KDB89_RS02190	COG1595	DNA-templated transcription, initiation
KDB89_RS02200	COG0095	Lipoate-protein ligase
KDB89_RS02210	COG0513	Belongs to the DEAD box helicase family
KDB89_RS02215	COG0406	alpha-ribazole phosphatase activity
KDB89_RS02225	COG1349	DNA-binding transcription factor activity
KDB89_RS02230	COG0508	dehydrogenase complex catalyzes the overall conversion of
KDB89_RS02235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KDB89_RS02240	COG0022	dehydrogenase e1 component
KDB89_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
KDB89_RS02290	COG0588	phosphoglycerate mutase activity
KDB89_RS02305	COG5002	protein histidine kinase activity
KDB89_RS02320	COG1329	Transcriptional regulator
KDB89_RS02325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KDB89_RS02330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KDB89_RS02345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KDB89_RS02355	COG0215	cysteine-tRNA ligase activity
KDB89_RS02380	COG0626	cystathionine gamma-synthase activity
KDB89_RS02385	COG3842	ATPase activity
KDB89_RS02490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KDB89_RS02520	COG0363	glucosamine-6-phosphate deaminase activity
KDB89_RS02525	COG1278	Cold shock
KDB89_RS02535	COG2252	PERMEase
KDB89_RS02540	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KDB89_RS02555	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KDB89_RS02570	COG2226	methyltransferase
KDB89_RS02575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KDB89_RS02580	COG0602	queuosine metabolic process
KDB89_RS02585	COG1328	CTP reductase activity
KDB89_RS02595	COG0674	pyruvate-flavodoxin oxidoreductase activity
KDB89_RS02595	COG1013	pyruvate-flavodoxin oxidoreductase activity
KDB89_RS02595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KDB89_RS02595	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KDB89_RS02605	COG2866	Carboxypeptidase
KDB89_RS02700	COG0732	type I restriction modification DNA specificity domain
KDB89_RS02700	COG0732	type I restriction modification DNA specificity domain
KDB89_RS02720	COG0477	Major facilitator Superfamily
KDB89_RS02735	COG0297	glycogen (starch) synthase activity
KDB89_RS02740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KDB89_RS02755	COG0489	protein tyrosine kinase activity
KDB89_RS02810	COG2233	PERMEase
KDB89_RS02835	COG0084	hydrolase, TatD family'
KDB89_RS02840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KDB89_RS02845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KDB89_RS02860	COG2818	Glycosylase
KDB89_RS02885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KDB89_RS02890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KDB89_RS02900	COG3732	PTS system glucitol sorbitol-specific
KDB89_RS02920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KDB89_RS02950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KDB89_RS02955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KDB89_RS02975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KDB89_RS02980	COG0193	aminoacyl-tRNA hydrolase activity
KDB89_RS03000	COG0148	phosphopyruvate hydratase activity
KDB89_RS03025	COG1780	Probably involved in ribonucleotide reductase function
KDB89_RS03030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KDB89_RS03035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KDB89_RS03040	COG4221	oxidoreductase activity
KDB89_RS03045	COG1028	Short-chain dehydrogenase reductase Sdr
KDB89_RS03060	COG3250	beta-galactosidase activity
KDB89_RS03070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KDB89_RS03075	COG3311	Transcriptional regulator
KDB89_RS03100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KDB89_RS03110	COG2268	Band 7 protein
KDB89_RS03150	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KDB89_RS03160	COG0494	nUDIX hydrolase
KDB89_RS03165	COG2321	neutral zinc metallopeptidase
KDB89_RS03180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KDB89_RS03190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KDB89_RS03205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KDB89_RS03215	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KDB89_RS03225	COG1331	Highly conserved protein containing a thioredoxin domain
KDB89_RS03230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KDB89_RS03245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KDB89_RS03255	COG1722	exodeoxyribonuclease VII activity
KDB89_RS03260	COG1570	exodeoxyribonuclease VII activity
KDB89_RS03270	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KDB89_RS03290	COG1322	Protein conserved in bacteria
KDB89_RS03295	COG1362	aminopeptidase activity
KDB89_RS03300	COG1846	Transcriptional regulator
KDB89_RS03305	COG1764	response to oxidative stress
KDB89_RS03310	COG0012	GTP binding
KDB89_RS03330	COG0454	-acetyltransferase
KDB89_RS03335	COG0477	Major facilitator Superfamily
KDB89_RS03355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KDB89_RS03360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KDB89_RS03380	COG1045	serine acetyltransferase
KDB89_RS03400	COG1335	isochorismatase
KDB89_RS03430	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KDB89_RS03445	COG0616	signal peptide processing
KDB89_RS03475	COG2171	N-acyltransferase activity
KDB89_RS03490	COG1305	Transglutaminase-like
KDB89_RS03495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KDB89_RS03515	COG0297	glycogen (starch) synthase activity
KDB89_RS03520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KDB89_RS03530	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KDB89_RS03535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KDB89_RS03550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KDB89_RS03555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KDB89_RS03555	COG3323	Protein of unknown function (DUF1653)
KDB89_RS03580	COG2239	Acts as a magnesium transporter
KDB89_RS03600	COG0006	proline dipeptidase activity
KDB89_RS03605	COG2860	membrane
KDB89_RS03615	COG1072	(Pantothenic acid kinase))
KDB89_RS03620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KDB89_RS03630	COG0444	Belongs to the ABC transporter superfamily
KDB89_RS03635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KDB89_RS03655	COG0736	holo-[acyl-carrier-protein] synthase activity
KDB89_RS03670	COG0438	transferase activity, transferring glycosyl groups
KDB89_RS03670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KDB89_RS03675	COG0513	Belongs to the DEAD box helicase family
KDB89_RS03680	COG0802	atpase or kinase
KDB89_RS03695	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KDB89_RS03700	COG0747	negative chemotaxis
KDB89_RS03710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KDB89_RS03730	COG3845	ABC transporter
KDB89_RS03780	COG0714	Associated with various cellular activities
KDB89_RS03790	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KDB89_RS03815	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KDB89_RS03820	COG0459	protein refolding
KDB89_RS03850	COG0516	GMP reductase activity
KDB89_RS03855	COG0287	Prephenate dehydrogenase
KDB89_RS03855	COG1605	Chorismate mutase
KDB89_RS03865	COG1309	transcriptional regulator
KDB89_RS03885	COG0494	nUDIX hydrolase
KDB89_RS03900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KDB89_RS03900	COG0519	Catalyzes the synthesis of GMP from XMP
KDB89_RS03925	COG2197	response regulator
KDB89_RS03955	COG0045	succinate-CoA ligase (ADP-forming) activity
KDB89_RS03980	COG0138	bifunctional purine biosynthesis protein purh
KDB89_RS03985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KDB89_RS04000	COG0039	L-malate dehydrogenase activity
KDB89_RS04005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KDB89_RS04020	COG1253	flavin adenine dinucleotide binding
KDB89_RS04035	COG3845	ABC transporter
KDB89_RS04040	COG4603	Belongs to the binding-protein-dependent transport system permease family
KDB89_RS04045	COG1079	Belongs to the binding-protein-dependent transport system permease family
KDB89_RS04055	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KDB89_RS04065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KDB89_RS04075	COG0328	RNA-DNA hybrid ribonuclease activity
KDB89_RS04080	COG3012	SEC-C Motif Domain Protein
KDB89_RS04090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KDB89_RS04110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KDB89_RS04125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KDB89_RS04145	COG4770	biotin carboxylase activity
KDB89_RS04165	COG0424	maF-like protein
KDB89_RS04175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KDB89_RS04205	COG1316	TRANSCRIPTIONal
KDB89_RS04275	COG2835	tetraacyldisaccharide 4'-kinase activity
KDB89_RS04285	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KDB89_RS04305	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KDB89_RS04305	COG0515	serine threonine protein kinase
KDB89_RS04325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KDB89_RS04335	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KDB89_RS04340	COG1940	carbohydrate kinase activity
KDB89_RS04350	COG1175	transmembrane transport
KDB89_RS04355	COG0395	ABC-type sugar transport system, permease component
KDB89_RS04360	COG1082	Xylose isomerase domain protein TIM barrel
KDB89_RS04375	COG5441	Belongs to the UPF0261 family
KDB89_RS04380	COG2204	response regulator
KDB89_RS04380	COG5564	TIM-barrel signal transduction protein
KDB89_RS04385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KDB89_RS04410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KDB89_RS04415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KDB89_RS04420	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KDB89_RS04425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KDB89_RS04430	COG1929	Belongs to the glycerate kinase type-1 family
KDB89_RS04450	COG3250	beta-galactosidase activity
KDB89_RS04460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KDB89_RS04470	COG0395	ABC-type sugar transport system, permease component
KDB89_RS04535	COG1739	Uncharacterized protein family UPF0029
KDB89_RS04555	COG0596	Alpha beta hydrolase
KDB89_RS04570	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KDB89_RS04580	COG1431	PFAM Stem cell self-renewal protein Piwi
KDB89_RS04680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KDB89_RS04685	COG1201	RNA secondary structure unwinding
KDB89_RS04695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KDB89_RS04700	COG0540	Belongs to the ATCase OTCase family
KDB89_RS04705	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KDB89_RS04725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KDB89_RS04735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KDB89_RS04855	COG1609	Transcriptional regulator
KDB89_RS04865	COG1175	transmembrane transport
KDB89_RS04870	COG0395	ABC-type sugar transport system, permease component
KDB89_RS04875	COG3250	beta-galactosidase activity
KDB89_RS04895	COG0544	peptidyl-prolyl cis-trans isomerase activity
KDB89_RS04900	COG0628	permease
KDB89_RS04905	COG0740	serine-type endopeptidase activity
KDB89_RS04910	COG0740	serine-type endopeptidase activity
KDB89_RS04915	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KDB89_RS04920	COG4946	Tricorn protease homolog
KDB89_RS04920	COG0793	Belongs to the peptidase S41A family
KDB89_RS04930	COG0525	valine-tRNA ligase activity
KDB89_RS04940	COG0285	dihydrofolate synthase activity
KDB89_RS04950	COG0105	UTP biosynthetic process
KDB89_RS04965	COG2267	carboxylic ester hydrolase activity
KDB89_RS04970	COG2807	transmembrane transport
KDB89_RS04980	COG1530	ribonuclease E activity
KDB89_RS04985	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KDB89_RS04995	COG0742	ribosomal rna small subunit methyltransferase
KDB89_RS05000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KDB89_RS05010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KDB89_RS05015	COG0571	ribonuclease III activity
KDB89_RS05020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KDB89_RS05030	COG1196	nuclear chromosome segregation
KDB89_RS05060	COG0228	four-way junction DNA binding
KDB89_RS05065	COG1837	Belongs to the UPF0109 family
KDB89_RS05070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KDB89_RS05075	COG0336	Belongs to the RNA methyltransferase TrmD family
KDB89_RS05085	COG1053	succinate dehydrogenase
KDB89_RS05090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KDB89_RS05095	COG0335	large ribosomal subunit rRNA binding
KDB89_RS05105	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KDB89_RS05115	COG0792	nuclease activity
KDB89_RS05130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KDB89_RS05165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KDB89_RS05170	COG4166	transmembrane transport
KDB89_RS05180	COG0444	Belongs to the ABC transporter superfamily
KDB89_RS05185	COG4608	Belongs to the ABC transporter superfamily
KDB89_RS05190	COG3012	SEC-C Motif Domain Protein
KDB89_RS05195	COG0667	Aldo Keto reductase
KDB89_RS05200	COG1968	undecaprenyl-diphosphatase activity
KDB89_RS05205	COG0588	phosphoglycerate mutase activity
KDB89_RS05220	COG0215	cysteine-tRNA ligase activity
KDB89_RS05225	COG0140	phosphoribosyl-ATP diphosphatase activity
KDB89_RS05230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KDB89_RS05255	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KDB89_RS05260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KDB89_RS05265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KDB89_RS05270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KDB89_RS05275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KDB89_RS05280	COG0072	phenylalanine-tRNA ligase activity
KDB89_RS05280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KDB89_RS05290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KDB89_RS05320	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KDB89_RS05325	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KDB89_RS05330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KDB89_RS05340	COG1438	arginine binding
KDB89_RS05345	COG0165	Argininosuccinate lyase
KDB89_RS05350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KDB89_RS05405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KDB89_RS05415	COG0504	CTP synthase activity
KDB89_RS05450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KDB89_RS05460	COG0545	Peptidyl-prolyl cis-trans isomerase
KDB89_RS05465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KDB89_RS05470	COG2378	regulation of single-species biofilm formation
KDB89_RS05485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KDB89_RS05490	COG0805	protein transport
KDB89_RS05505	COG4581	dead DEAH box helicase
KDB89_RS05510	COG0107	imidazoleglycerol-phosphate synthase activity
KDB89_RS05515	COG0537	adenosine 5'-monophosphoramidase activity
KDB89_RS05530	COG0440	acetolactate synthase activity
KDB89_RS05535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KDB89_RS05540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KDB89_RS05545	COG2239	Acts as a magnesium transporter
KDB89_RS05550	COG0473	3-isopropylmalate dehydrogenase activity
KDB89_RS05555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KDB89_RS05560	COG0179	Fumarylacetoacetate (FAA) hydrolase
KDB89_RS05565	COG1266	CAAX protease self-immunity
KDB89_RS05590	COG1053	succinate dehydrogenase
KDB89_RS05605	COG1414	Transcriptional regulator
KDB89_RS05610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KDB89_RS05615	COG0066	3-isopropylmalate dehydratase activity
KDB89_RS05620	COG1505	serine-type exopeptidase activity
KDB89_RS05650	COG1181	Belongs to the D-alanine--D-alanine ligase family
KDB89_RS05660	COG1674	ftsk spoiiie
KDB89_RS05665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KDB89_RS05675	COG1058	Belongs to the CinA family
KDB89_RS05675	COG1546	Belongs to the CinA family
KDB89_RS05705	COG1418	mRNA catabolic process
KDB89_RS05710	COG2017	converts alpha-aldose to the beta-anomer
KDB89_RS05715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KDB89_RS05720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KDB89_RS05725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KDB89_RS05730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KDB89_RS05740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KDB89_RS05755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KDB89_RS05765	COG0129	dihydroxy-acid dehydratase activity
KDB89_RS05805	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KDB89_RS05810	COG1492	cobalamin metabolic process
KDB89_RS05830	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
KDB89_RS05840	COG0310	cobalt ion transport
KDB89_RS05845	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
KDB89_RS05870	COG1797	cobyrinic acid a,c-diamide synthase activity
KDB89_RS05875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KDB89_RS05875	COG1648	precorrin-2 dehydrogenase activity
KDB89_RS05885	COG3537	Alpha-1,2-mannosidase
KDB89_RS05895	COG2130	NADP-dependent
KDB89_RS05910	COG0535	radical SAM domain protein
KDB89_RS05930	COG1643	Atp-dependent helicase
KDB89_RS05935	COG1946	Acyl-CoA thioesterase
KDB89_RS05945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KDB89_RS05960	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KDB89_RS05975	COG1074	ATP-dependent DNA helicase activity
KDB89_RS05980	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KDB89_RS06010	COG3480	Lon protease (S16) C-terminal proteolytic domain
KDB89_RS06020	COG1615	UPF0182 protein
KDB89_RS06035	COG0667	Aldo Keto reductase
KDB89_RS06040	COG0672	)-iron permease
KDB89_RS06050	COG2837	iron assimilation
KDB89_RS06065	COG4115	mRNA cleavage
KDB89_RS06070	COG2161	toxin-antitoxin pair type II binding
KDB89_RS06090	COG1309	transcriptional regulator
KDB89_RS06095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KDB89_RS06105	COG0579	oxidoreductase
KDB89_RS06170	COG4129	membrane
KDB89_RS06175	COG0747	negative chemotaxis
KDB89_RS06185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KDB89_RS06190	COG0444	Belongs to the ABC transporter superfamily
KDB89_RS06195	COG4608	Belongs to the ABC transporter superfamily
KDB89_RS06200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KDB89_RS06205	COG0483	inositol monophosphate 1-phosphatase activity
KDB89_RS06210	COG1162	GTPase activity
KDB89_RS06215	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KDB89_RS06225	COG2135	peptidase activity
KDB89_RS06230	COG1595	DNA-templated transcription, initiation
KDB89_RS06265	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KDB89_RS06275	COG0567	Dehydrogenase, E1 component
KDB89_RS06275	COG0508	dehydrogenase complex catalyzes the overall conversion of
KDB89_RS06290	COG0019	diaminopimelate decarboxylase activity
KDB89_RS06295	COG0460	homoserine dehydrogenase
KDB89_RS06300	COG0083	homoserine kinase activity
KDB89_RS06310	COG0254	rRNA binding
KDB89_RS06315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KDB89_RS06320	COG2890	protein-(glutamine-N5) methyltransferase activity
KDB89_RS06330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KDB89_RS06345	COG0356	it plays a direct role in the translocation of protons across the membrane
KDB89_RS06355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KDB89_RS06360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KDB89_RS06365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KDB89_RS06370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KDB89_RS06375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KDB89_RS06380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KDB89_RS06395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KDB89_RS06400	COG0596	Alpha beta hydrolase
KDB89_RS06410	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
KDB89_RS06415	COG0628	permease
KDB89_RS06460	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KDB89_RS06470	COG0366	Alpha amylase catalytic
KDB89_RS06485	COG0482	sulfurtransferase activity
KDB89_RS06500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KDB89_RS06505	COG0154	amidase activity
KDB89_RS06510	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KDB89_RS06525	COG1506	peptidase
KDB89_RS06525	COG4946	Tricorn protease homolog
KDB89_RS06525	COG0823	Involved in the tonB-independent uptake of proteins
KDB89_RS06535	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KDB89_RS06540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KDB89_RS06555	COG0134	indole-3-glycerol-phosphate synthase activity
KDB89_RS06560	COG0133	tryptophan synthase activity
KDB89_RS06570	COG0067	glutamate synthase
KDB89_RS06570	COG0069	glutamate synthase activity
KDB89_RS06570	COG0070	glutamate synthase
KDB89_RS06580	COG0698	ribose 5-phosphate isomerase
KDB89_RS06590	COG1653	transport
KDB89_RS06595	COG1175	transmembrane transport
KDB89_RS06620	COG0587	DNA-directed DNA polymerase activity
KDB89_RS06630	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KDB89_RS06635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KDB89_RS06640	COG0131	Imidazoleglycerol-phosphate dehydratase
KDB89_RS06645	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KDB89_RS06650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KDB89_RS06675	COG0217	transcriptional regulatory protein
KDB89_RS06680	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KDB89_RS06685	COG0632	four-way junction helicase activity
KDB89_RS06690	COG2255	four-way junction helicase activity
KDB89_RS06695	COG1862	Preprotein translocase
KDB89_RS06700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KDB89_RS06705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KDB89_RS06710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KDB89_RS06720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KDB89_RS06725	COG1196	nuclear chromosome segregation
KDB89_RS06730	COG0124	histidyl-tRNA synthetase
KDB89_RS06740	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KDB89_RS06745	COG2814	Major facilitator Superfamily
KDB89_RS06765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KDB89_RS06770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KDB89_RS06780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KDB89_RS06785	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KDB89_RS06790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KDB89_RS06795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KDB89_RS06800	COG0477	Major facilitator Superfamily
KDB89_RS06815	COG2826	transposase and inactivated derivatives, IS30 family
KDB89_RS06835	COG1120	ATPase activity
KDB89_RS06840	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KDB89_RS06845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KDB89_RS06890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KDB89_RS06895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KDB89_RS06900	COG0505	Belongs to the CarA family
KDB89_RS06905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KDB89_RS06910	COG0167	dihydroorotate dehydrogenase activity
KDB89_RS06915	COG0284	orotidine-5'-phosphate decarboxylase activity
KDB89_RS06925	COG0194	GDP metabolic process
KDB89_RS06930	COG1758	RNA polymerase activity
KDB89_RS06935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KDB89_RS06945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KDB89_RS06955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KDB89_RS06970	COG0646	methionine synthase
KDB89_RS06970	COG1410	methionine synthase
KDB89_RS06975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KDB89_RS07005	COG0667	Aldo Keto reductase
KDB89_RS07020	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KDB89_RS07025	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KDB89_RS07035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KDB89_RS07040	COG1160	GTP binding
KDB89_RS07110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KDB89_RS07180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KDB89_RS07195	COG1120	ATPase activity
KDB89_RS07200	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KDB89_RS07205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KDB89_RS07215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KDB89_RS07225	COG1132	(ABC) transporter
KDB89_RS07230	COG1132	(ABC) transporter
KDB89_RS07240	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
KDB89_RS07250	COG1254	Belongs to the acylphosphatase family
KDB89_RS07260	COG0492	ferredoxin-NADP+ reductase activity
KDB89_RS07275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KDB89_RS07340	COG2826	transposase and inactivated derivatives, IS30 family
KDB89_RS07380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KDB89_RS07390	COG1653	transport
KDB89_RS07395	COG1175	transmembrane transport
KDB89_RS07400	COG0395	ABC-type sugar transport system, permease component
KDB89_RS07430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KDB89_RS07435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KDB89_RS07435	COG2813	Specifically methylates the guanine in position
KDB89_RS07440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KDB89_RS07455	COG1216	Glycosyl transferase, family 2
KDB89_RS07460	COG3030	protein affecting phage T7 exclusion by the F plasmid
KDB89_RS07475	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
KDB89_RS07490	COG2190	(PTS) system
KDB89_RS07495	COG2161	toxin-antitoxin pair type II binding
KDB89_RS07520	COG0009	L-threonylcarbamoyladenylate synthase
KDB89_RS07540	COG1295	ribonuclease BN
KDB89_RS07560	COG1716	ATPase activity
KDB89_RS07585	COG0438	transferase activity, transferring glycosyl groups
KDB89_RS07600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KDB89_RS07610	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KDB89_RS07615	COG5006	permease, DMT superfamily
KDB89_RS07645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KDB89_RS07655	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KDB89_RS07660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KDB89_RS07670	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KDB89_RS07675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KDB89_RS07680	COG0531	amino acid
KDB89_RS07685	COG0569	domain protein
KDB89_RS07705	COG0756	dUTP diphosphatase activity
KDB89_RS07730	COG1435	thymidine kinase activity
KDB89_RS07755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KDB89_RS07765	COG1802	Transcriptional regulator
KDB89_RS07770	COG1620	l-lactate permease
KDB89_RS07775	COG0247	lactate metabolic process
KDB89_RS07780	COG1139	Iron-sulfur cluster binding protein
KDB89_RS07785	COG1556	Lactate utilization protein
KDB89_RS07790	COG0187	DNA topoisomerase II activity
KDB89_RS07805	COG0210	DNA helicase
KDB89_RS07810	COG0210	DNA helicase
KDB89_RS07815	COG1793	dna ligase
KDB89_RS07815	COG3285	dna ligase
KDB89_RS07840	COG0180	Tryptophanyl-tRNA synthetase
KDB89_RS07845	COG0613	PHP domain protein
KDB89_RS07860	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KDB89_RS07875	COG0653	protein targeting
KDB89_RS07880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KDB89_RS07885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KDB89_RS07895	COG5002	protein histidine kinase activity
KDB89_RS07900	COG0745	RESPONSE REGULATOR receiver
KDB89_RS07905	COG1678	Uncharacterized ACR, COG1678
KDB89_RS07925	COG0693	protein deglycase activity
KDB89_RS07955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KDB89_RS07960	COG0739	heme binding
KDB89_RS07960	COG1196	nuclear chromosome segregation
KDB89_RS07960	COG0741	lytic transglycosylase activity
KDB89_RS07970	COG2884	Cell division ATP-binding protein ftsE
KDB89_RS07975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KDB89_RS07990	COG0494	nUDIX hydrolase
KDB89_RS08035	COG0702	epimerase
KDB89_RS08055	COG1174	glycine betaine transport
KDB89_RS08060	COG1174	glycine betaine transport
KDB89_RS08080	COG1937	Protein conserved in bacteria
KDB89_RS08085	COG0446	pyridine nucleotide-disulphide oxidoreductase
KDB89_RS08100	COG0673	inositol 2-dehydrogenase activity
KDB89_RS08130	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KDB89_RS08150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KDB89_RS08155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KDB89_RS08160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KDB89_RS08170	COG3458	cephalosporin-C deacetylase activity
KDB89_RS08175	COG2304	oxidoreductase activity
KDB89_RS08180	COG2304	oxidoreductase activity
KDB89_RS08190	COG0714	Associated with various cellular activities
KDB89_RS08210	COG1414	Transcriptional regulator
KDB89_RS08230	COG0129	dihydroxy-acid dehydratase activity
KDB89_RS08245	COG2815	serine threonine protein kinase
KDB89_RS08245	COG0515	serine threonine protein kinase
KDB89_RS08265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KDB89_RS08315	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KDB89_RS08330	COG1120	ATPase activity
KDB89_RS08335	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KDB89_RS08340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KDB89_RS08365	COG3443	Belongs to the bacterial solute-binding protein 9 family
KDB89_RS08365	COG0803	Belongs to the bacterial solute-binding protein 9 family
KDB89_RS08370	COG1121	(ABC) transporter
KDB89_RS08375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KDB89_RS08385	COG0384	phenazine biosynthesis protein PhzF
KDB89_RS08390	COG0561	phosphatase activity
KDB89_RS08395	COG1381	Involved in DNA repair and RecF pathway recombination
KDB89_RS08400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KDB89_RS08420	COG3328	transposase activity
KDB89_RS08435	COG1305	Transglutaminase-like
KDB89_RS08440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KDB89_RS08445	COG0395	ABC-type sugar transport system, permease component
KDB89_RS08450	COG1175	transmembrane transport
KDB89_RS08460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KDB89_RS08470	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KDB89_RS08490	COG0667	Aldo Keto reductase
KDB89_RS08495	COG0343	queuine tRNA-ribosyltransferase activity
KDB89_RS08505	COG0484	heat shock protein binding
KDB89_RS08510	COG1420	regulation of RNA biosynthetic process
KDB89_RS08520	COG2160	L-arabinose isomerase activity
KDB89_RS08530	COG1609	Transcriptional regulator
KDB89_RS08545	COG1131	(ABC) transporter
KDB89_RS08550	COG1725	Transcriptional regulator
KDB89_RS08565	COG0481	GTPase activity
KDB89_RS08595	COG0658	competence protein
KDB89_RS08595	COG2333	competence protein COMEC
KDB89_RS08600	COG1555	photosystem II stabilization
KDB89_RS08600	COG1596	polysaccharide export
KDB89_RS08605	COG0495	leucyl-tRNA aminoacylation
KDB89_RS08610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KDB89_RS08655	COG2855	membrane
KDB89_RS08670	COG0659	secondary active sulfate transmembrane transporter activity
KDB89_RS08680	COG0395	ABC-type sugar transport system, permease component
KDB89_RS08685	COG1175	transmembrane transport
KDB89_RS08695	COG1486	melibiose metabolic process
KDB89_RS08730	COG3534	alpha-L-arabinofuranosidase
KDB89_RS08740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KDB89_RS08765	COG0181	hydroxymethylbilane synthase activity
KDB89_RS08770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KDB89_RS08785	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KDB89_RS08790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KDB89_RS08795	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KDB89_RS08810	COG0406	alpha-ribazole phosphatase activity
KDB89_RS08815	COG0799	negative regulation of ribosome biogenesis
KDB89_RS08820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KDB89_RS08830	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KDB89_RS08840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KDB89_RS08845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KDB89_RS08850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KDB89_RS08855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KDB89_RS08860	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KDB89_RS08875	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KDB89_RS08880	COG1185	polyribonucleotide nucleotidyltransferase activity
KDB89_RS08885	COG0506	proline dehydrogenase activity
KDB89_RS08885	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KDB89_RS08885	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KDB89_RS08890	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KDB89_RS08905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KDB89_RS08910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KDB89_RS08915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KDB89_RS08930	COG0195	Participates in both transcription termination and antitermination
KDB89_RS08935	COG0779	Required for maturation of 30S ribosomal subunits
KDB89_RS08945	COG0442	prolyl-tRNA aminoacylation
KDB89_RS08955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KDB89_RS08960	COG0750	zinc metalloprotease
KDB89_RS08965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KDB89_RS08995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KDB89_RS09015	COG1228	amidohydrolase
KDB89_RS09020	COG1403	HNH endonuclease
KDB89_RS09030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KDB89_RS09065	COG0233	cytoplasmic translational termination
KDB89_RS09070	COG0528	UMP kinase activity
KDB89_RS09075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KDB89_RS09080	COG0052	Belongs to the universal ribosomal protein uS2 family
KDB89_RS09085	COG0739	heme binding
KDB89_RS09085	COG0741	lytic transglycosylase activity
KDB89_RS09085	COG1196	nuclear chromosome segregation
KDB89_RS09090	COG4974	Belongs to the 'phage' integrase family
KDB89_RS09095	COG0242	peptide deformylase activity
KDB89_RS09105	COG1309	transcriptional regulator
KDB89_RS09110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KDB89_RS09130	COG1119	ATPase activity
KDB89_RS09140	COG1028	Short-chain dehydrogenase reductase Sdr
KDB89_RS09155	COG2226	methyltransferase
KDB89_RS09160	COG2190	(PTS) system
KDB89_RS09160	COG2211	Major facilitator Superfamily
KDB89_RS09165	COG0366	Alpha amylase catalytic
KDB89_RS09170	COG0488	(ABC) transporter
KDB89_RS09205	COG0822	iron-sulfur transferase activity
KDB89_RS09210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KDB89_RS09215	COG0396	ATPase activity
KDB89_RS09255	COG0339	signal peptide processing
KDB89_RS09265	COG2814	Major facilitator Superfamily
KDB89_RS09270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KDB89_RS09280	COG3842	ATPase activity
KDB89_RS09285	COG1136	(ABC) transporter
KDB89_RS09285	COG0577	efflux transmembrane transporter activity
KDB89_RS09305	COG0109	protoheme IX farnesyltransferase activity
KDB89_RS09320	COG0363	glucosamine-6-phosphate deaminase activity
KDB89_RS09330	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KDB89_RS09335	COG0149	triose-phosphate isomerase activity
KDB89_RS09340	COG0126	phosphoglycerate kinase activity
KDB89_RS09345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KDB89_RS09350	COG1481	regulation of sporulation
KDB89_RS09360	COG1660	Displays ATPase and GTPase activities
KDB89_RS09370	COG1122	ATPase activity
KDB89_RS09375	COG1268	BioY protein
KDB89_RS09390	COG0322	excinuclease ABC activity
KDB89_RS09400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KDB89_RS09415	COG0556	nucleotide-excision repair
KDB89_RS09420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KDB89_RS09425	COG0237	dephospho-CoA kinase activity
KDB89_RS09435	COG0539	negative regulation of cytoplasmic translation
KDB89_RS09450	COG2050	protein possibly involved in aromatic compounds catabolism
KDB89_RS09465	COG0469	pyruvate kinase activity
KDB89_RS09475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KDB89_RS09490	COG1799	cell septum assembly
KDB89_RS09495	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KDB89_RS09505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KDB89_RS09510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KDB89_RS09515	COG0772	Belongs to the SEDS family
KDB89_RS09520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KDB89_RS09525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KDB89_RS09530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KDB89_RS09535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KDB89_RS09540	COG0768	penicillin binding
KDB89_RS09550	COG0275	rRNA processing
KDB89_RS09555	COG2001	Belongs to the MraZ family
KDB89_RS09560	COG0714	Associated with various cellular activities
KDB89_RS09580	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KDB89_RS09585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KDB89_RS09590	COG0587	DNA-directed DNA polymerase activity
KDB89_RS09610	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KDB89_RS09610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KDB89_RS09615	COG3973	AAA domain
KDB89_RS09625	COG0142	geranyltranstransferase activity
KDB89_RS09630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KDB89_RS09635	COG0515	serine threonine protein kinase
KDB89_RS09635	COG2815	serine threonine protein kinase
KDB89_RS09645	COG3250	beta-galactosidase activity
KDB89_RS09680	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KDB89_RS09685	COG2197	response regulator
KDB89_RS09690	COG2205	protein histidine kinase activity
KDB89_RS09715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KDB89_RS09725	COG3214	Protein conserved in bacteria
KDB89_RS09735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KDB89_RS09745	COG1845	cytochrome c oxidase, subunit III
KDB89_RS09750	COG2010	Cytochrome c
KDB89_RS09755	COG0723	plastoquinol--plastocyanin reductase activity
KDB89_RS09760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KDB89_RS09770	COG4152	abc transporter atp-binding protein
KDB89_RS09775	COG1668	transmembrane transport
KDB89_RS09780	COG0477	Major facilitator Superfamily
KDB89_RS09790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KDB89_RS09795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KDB89_RS09835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KDB89_RS09840	COG0508	dehydrogenase complex catalyzes the overall conversion of
KDB89_RS09845	COG0321	lipoyl(octanoyl) transferase activity
KDB89_RS09860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KDB89_RS09870	COG0488	(ABC) transporter
KDB89_RS09880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KDB89_RS09905	COG0656	L-ascorbic acid biosynthetic process
KDB89_RS09910	COG4133	protoheme IX ABC transporter activity
KDB89_RS09920	COG1823	symporter activity
KDB89_RS09925	COG0174	glutamine synthetase
KDB89_RS09930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KDB89_RS09945	COG0210	DNA helicase
KDB89_RS09955	COG2409	Drug exporters of the RND superfamily
KDB89_RS09960	COG0604	alcohol dehydrogenase
KDB89_RS09975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KDB89_RS09980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KDB89_RS09985	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KDB89_RS09995	COG0174	glutamine synthetase
KDB89_RS10030	COG2814	Major facilitator Superfamily
KDB89_RS10055	COG0557	exoribonuclease II activity
KDB89_RS10065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KDB89_RS10070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KDB89_RS10075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KDB89_RS10090	COG3304	Inner membrane component domain
KDB89_RS10095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KDB89_RS10100	COG0101	tRNA pseudouridine synthase activity
KDB89_RS10120	COG0438	transferase activity, transferring glycosyl groups
KDB89_RS10150	COG1609	Transcriptional regulator
KDB89_RS10155	COG3842	ATPase activity
KDB89_RS10160	COG4120	Belongs to the binding-protein-dependent transport system permease family
KDB89_RS10175	COG0203	ribosomal protein L17
KDB89_RS10180	COG0202	RNA polymerase activity
KDB89_RS10185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KDB89_RS10190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KDB89_RS10195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KDB89_RS10200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KDB89_RS10205	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KDB89_RS10235	COG0563	adenylate kinase activity
KDB89_RS10240	COG0201	protein transport
KDB89_RS10245	COG0200	Binds to the 23S rRNA
KDB89_RS10250	COG1841	ribosomal large subunit assembly
KDB89_RS10255	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KDB89_RS10260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KDB89_RS10265	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KDB89_RS10270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KDB89_RS10275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KDB89_RS10280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KDB89_RS10285	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KDB89_RS10290	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KDB89_RS10295	COG0577	efflux transmembrane transporter activity
KDB89_RS10295	COG1136	(ABC) transporter
KDB89_RS10300	COG1950	PFAM Membrane protein of
KDB89_RS10305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KDB89_RS10310	COG0255	Belongs to the universal ribosomal protein uL29 family
KDB89_RS10315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KDB89_RS10320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KDB89_RS10325	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KDB89_RS10330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KDB89_RS10335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KDB89_RS10340	COG0089	rRNA binding
KDB89_RS10345	COG0088	Forms part of the polypeptide exit tunnel
KDB89_RS10350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KDB89_RS10355	COG0051	transcription antitermination factor activity, RNA binding
KDB89_RS10360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KDB89_RS10370	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KDB89_RS10370	COG0517	IMP dehydrogenase activity
KDB89_RS10380	COG1051	belongs to the nudix hydrolase family
KDB89_RS10390	COG0481	GTPase activity
KDB89_RS10400	COG0435	Glutathione S-transferase
KDB89_RS10405	COG0281	malic enzyme
KDB89_RS10410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KDB89_RS10420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KDB89_RS10425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KDB89_RS10430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KDB89_RS10435	COG0049	tRNA binding
KDB89_RS10440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KDB89_RS10445	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KDB89_RS10450	COG0085	RNA polymerase activity
KDB89_RS10455	COG0222	ribosome binding
KDB89_RS10460	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KDB89_RS10470	COG0765	amino acid transport
KDB89_RS10480	COG1024	Enoyl-CoA hydratase
KDB89_RS10500	COG0081	regulation of translation
KDB89_RS10505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KDB89_RS10510	COG0250	Participates in transcription elongation, termination and antitermination
KDB89_RS10525	COG1132	(ABC) transporter
KDB89_RS10530	COG1132	(ABC) transporter
KDB89_RS10535	COG1473	amidohydrolase
KDB89_RS10540	COG1705	Flagellar rod assembly protein muramidase FlgJ
KDB89_RS10540	COG3951	Flagellar rod assembly protein muramidase FlgJ
KDB89_RS10545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KDB89_RS10555	COG2030	dehydratase
KDB89_RS10560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KDB89_RS10575	COG0813	purine-nucleoside phosphorylase activity
KDB89_RS10585	COG1666	GTP binding
KDB89_RS10590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KDB89_RS10615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KDB89_RS10625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KDB89_RS10630	COG0674	pyruvate-flavodoxin oxidoreductase activity
KDB89_RS10630	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KDB89_RS10635	COG1013	pyruvate-flavodoxin oxidoreductase activity
KDB89_RS10665	COG0142	geranyltranstransferase activity
KDB89_RS10670	COG1007	ATP synthesis coupled electron transport
KDB89_RS10695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KDB89_RS10700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KDB89_RS10705	COG1034	ATP synthesis coupled electron transport
KDB89_RS10710	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KDB89_RS10720	COG0649	NAD binding
KDB89_RS10725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KDB89_RS10730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KDB89_RS10740	COG0644	oxidoreductase
KDB89_RS10745	COG1169	isochorismate synthase
KDB89_RS10755	COG1116	anion transmembrane transporter activity
KDB89_RS10760	COG2226	methyltransferase
KDB89_RS10770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KDB89_RS10775	COG4948	Mandelate Racemase Muconate Lactonizing
KDB89_RS10780	COG1575	Belongs to the MenA family. Type 1 subfamily
KDB89_RS10795	COG1461	Dihydroxyacetone kinase
KDB89_RS10800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KDB89_RS10805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KDB89_RS10810	COG0752	glycyl-tRNA synthetase alpha subunit
KDB89_RS10810	COG0751	glycine-tRNA ligase activity
KDB89_RS10835	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KDB89_RS10840	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KDB89_RS10845	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KDB89_RS10920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KDB89_RS10935	COG2838	Isocitrate dehydrogenase
KDB89_RS10950	COG0596	Alpha beta hydrolase
KDB89_RS10975	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KDB89_RS10980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KDB89_RS10990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KDB89_RS11010	COG1136	(ABC) transporter
KDB89_RS11010	COG0577	efflux transmembrane transporter activity
KDB89_RS11015	COG1136	(ABC) transporter
KDB89_RS11055	COG3585	molybdate ion transport
KDB89_RS11060	COG0521	Mo-molybdopterin cofactor biosynthetic process
KDB89_RS11060	COG0315	cyclic pyranopterin monophosphate synthase activity
KDB89_RS11065	COG0315	cyclic pyranopterin monophosphate synthase activity
KDB89_RS11080	COG0314	molybdopterin synthase activity
KDB89_RS11105	COG1140	nitrate reductase beta subunit
KDB89_RS11115	COG0746	molybdenum cofactor guanylyltransferase activity
KDB89_RS11140	COG2070	2-Nitropropane dioxygenase
KDB89_RS11145	COG1024	Enoyl-CoA hydratase
KDB89_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
KDB89_RS11165	COG1027	Aspartate ammonia-lyase
KDB89_RS11195	COG1902	pentaerythritol trinitrate reductase activity
KDB89_RS11205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KDB89_RS11220	COG0047	phosphoribosylformylglycinamidine synthase activity
KDB89_RS11225	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KDB89_RS11230	COG0436	Aminotransferase
KDB89_RS11235	COG2094	Belongs to the DNA glycosylase MPG family
KDB89_RS11250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KDB89_RS11265	COG0175	sulfate reduction
KDB89_RS11280	COG1175	transmembrane transport
KDB89_RS11285	COG0395	ABC-type sugar transport system, permease component
KDB89_RS11290	COG1653	transport
KDB89_RS11305	COG1126	abc transporter atp-binding protein
KDB89_RS11310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KDB89_RS11315	COG0765	amino acid transport
KDB89_RS11320	COG0765	amino acid transport
KDB89_RS11325	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
KDB89_RS11330	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KDB89_RS11335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KDB89_RS11340	COG0024	Methionine aminopeptidase
KDB89_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
KDB89_RS11355	COG0183	Belongs to the thiolase family
KDB89_RS11380	COG0151	Belongs to the GarS family
KDB89_RS11390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KDB89_RS11395	COG2376	Dihydroxyacetone kinase
KDB89_RS11400	COG1461	Dihydroxyacetone kinase
KDB89_RS11405	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
KDB89_RS11405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KDB89_RS11405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KDB89_RS11435	COG1472	Belongs to the glycosyl hydrolase 3 family
KDB89_RS11445	COG1175	transmembrane transport
KDB89_RS11460	COG1217	gtp-binding protein TYPA
KDB89_RS11470	COG2337	Toxic component of a toxin-antitoxin (TA) module
KDB89_RS11480	COG0697	spore germination
KDB89_RS11485	COG2326	polyphosphate kinase activity
KDB89_RS11490	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KDB89_RS11500	COG1609	Transcriptional regulator
KDB89_RS11515	COG1175	transmembrane transport
KDB89_RS11520	COG3833	ABC-type maltose transport systems, permease component
KDB89_RS11525	COG0354	folic acid binding
KDB89_RS11530	COG3485	protocatechuate 3,4-dioxygenase
KDB89_RS11535	COG1490	D-aminoacyl-tRNA deacylase activity
KDB89_RS11545	COG0745	RESPONSE REGULATOR receiver
KDB89_RS11550	COG0454	-acetyltransferase
KDB89_RS11550	COG0456	acetyltransferase
KDB89_RS11555	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KDB89_RS11580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KDB89_RS11585	COG1472	Belongs to the glycosyl hydrolase 3 family
KDB89_RS11595	COG3328	transposase activity
KDB89_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
KDB89_RS11615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KDB89_RS11625	COG0785	Cytochrome C biogenesis protein
KDB89_RS11630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KDB89_RS11635	COG0406	alpha-ribazole phosphatase activity
KDB89_RS11640	COG1648	precorrin-2 dehydrogenase activity
KDB89_RS11640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KDB89_RS11655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KDB89_RS11670	COG0506	proline dehydrogenase activity
KDB89_RS11675	COG1082	Xylose isomerase domain protein TIM barrel
KDB89_RS11695	COG2226	methyltransferase
KDB89_RS11700	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KDB89_RS11700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KDB89_RS11710	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KDB89_RS11715	COG0142	geranyltranstransferase activity
KDB89_RS11730	COG2124	cytochrome p450
KDB89_RS11735	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KDB89_RS11740	COG0789	Transcriptional regulator
KDB89_RS11750	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
KDB89_RS11755	COG4143	(ABC) transporter
KDB89_RS11765	COG3842	ATPase activity
KDB89_RS11775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KDB89_RS11790	COG0649	NAD binding
KDB89_RS11810	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KDB89_RS11815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KDB89_RS11820	COG0302	gtp cyclohydrolase
KDB89_RS11835	COG0037	tRNA processing
KDB89_RS11850	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KDB89_RS11855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KDB89_RS11860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KDB89_RS11930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KDB89_RS11935	COG0730	response to heat
KDB89_RS11940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KDB89_RS11950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KDB89_RS11950	COG1754	DNA topoisomerase type I activity
KDB89_RS11960	COG0667	Aldo Keto reductase
KDB89_RS11980	COG1205	dead DEAH box helicase
KDB89_RS11980	COG1111	helicase
KDB89_RS12060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KDB89_RS12075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KDB89_RS12080	COG1408	metallophosphoesterase
KDB89_RS12105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KDB89_RS12105	COG1648	precorrin-2 dehydrogenase activity
KDB89_RS12140	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
KDB89_RS12150	COG0673	inositol 2-dehydrogenase activity
KDB89_RS12165	COG1131	(ABC) transporter
KDB89_RS12175	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KDB89_RS12180	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KDB89_RS12215	COG3093	addiction module antidote protein HigA
KDB89_RS12235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KDB89_RS12240	COG1131	(ABC) transporter
KDB89_RS12245	COG1129	ABC transporter
KDB89_RS12245	COG0842	Transport permease protein
KDB89_RS12250	COG0842	Transport permease protein
KDB89_RS12255	COG1131	(ABC) transporter
KDB89_RS12265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KDB89_RS12280	COG1069	ribulokinase activity
KDB89_RS12285	COG0647	UMP catabolic process
KDB89_RS12295	COG0698	ribose 5-phosphate isomerase
KDB89_RS12300	COG1349	DNA-binding transcription factor activity
KDB89_RS12330	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KDB89_RS12340	COG2813	Specifically methylates the guanine in position
KDB89_RS12345	COG3328	transposase activity
KDB89_RS12350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KDB89_RS12355	COG3830	Belongs to the UPF0237 family
KDB89_RS12355	COG0560	Phosphoserine phosphatase
KDB89_RS12365	COG2095	MarC family integral membrane protein
KDB89_RS12370	COG0277	FAD linked oxidase domain protein
KDB89_RS12400	COG0598	Magnesium transport protein CorA
KDB89_RS12410	COG1115	amino acid carrier protein
KDB89_RS12420	COG3655	Transcriptional regulator
KDB89_RS12430	COG1473	amidohydrolase
KDB89_RS12450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KDB89_RS12455	COG2011	ABC-type metal ion transport system permease component
KDB89_RS12460	COG1464	Belongs to the NlpA lipoprotein family
KDB89_RS12465	COG0546	phosphoglycolate phosphatase activity
KDB89_RS12475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KDB89_RS12535	COG0277	FAD linked oxidase domain protein
KDB89_RS12545	COG0205	6-phosphofructokinase activity
KDB89_RS12565	COG1420	regulation of RNA biosynthetic process
KDB89_RS12570	COG1940	carbohydrate kinase activity
KDB89_RS12575	COG0018	arginyl-trna synthetase
KDB89_RS12585	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KDB89_RS12595	COG0166	Belongs to the GPI family
KDB89_RS12655	COG0438	transferase activity, transferring glycosyl groups
KDB89_RS12670	COG1070	Carbohydrate kinase
KDB89_RS12680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KDB89_RS12695	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KDB89_RS12710	COG1716	ATPase activity
KDB89_RS12730	COG0768	penicillin binding
KDB89_RS12735	COG0515	serine threonine protein kinase
KDB89_RS12755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KDB89_RS12760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KDB89_RS12805	COG2514	catechol 2,3-dioxygenase activity
KDB89_RS12810	COG2326	polyphosphate kinase activity
KDB89_RS12820	COG1271	oxidase subunit
KDB89_RS12825	COG1294	oxidase, subunit
KDB89_RS12830	COG4988	ABC transporter
KDB89_RS12835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KDB89_RS12860	COG3958	Transketolase
KDB89_RS12865	COG3959	Transketolase, thiamine diphosphate binding domain
KDB89_RS12870	COG1082	Xylose isomerase domain protein TIM barrel
KDB89_RS12875	COG1879	ABC-type sugar transport system periplasmic component
KDB89_RS12880	COG1172	Belongs to the binding-protein-dependent transport system permease family
KDB89_RS12885	COG1129	ABC transporter
KDB89_RS12895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KDB89_RS12900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KDB89_RS12905	COG4154	Belongs to the RbsD FucU family
KDB89_RS12920	COG0114	fumarate hydratase activity
KDB89_RS12925	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KDB89_RS12940	COG1937	Protein conserved in bacteria
KDB89_RS12945	COG0305	Participates in initiation and elongation during chromosome replication
KDB89_RS12960	COG1742	UPF0060 membrane protein
KDB89_RS12970	COG1397	ADP-ribosylglycohydrolase
KDB89_RS12975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KDB89_RS12980	COG0686	Belongs to the AlaDH PNT family
KDB89_RS13005	COG0514	ATP-dependent DNA helicase (RecQ)
KDB89_RS13035	COG1597	lipid kinase activity
KDB89_RS13055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KDB89_RS13070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KDB89_RS13085	COG0747	negative chemotaxis
KDB89_RS13090	COG0601	transmembrane transport
KDB89_RS13095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KDB89_RS13120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KDB89_RS13150	COG0477	Major facilitator Superfamily
KDB89_RS13155	COG1621	beta-fructofuranosidase activity
KDB89_RS13160	COG0395	ABC-type sugar transport system, permease component
KDB89_RS13165	COG1175	transmembrane transport
KDB89_RS13175	COG1609	Transcriptional regulator
KDB89_RS13200	COG3458	cephalosporin-C deacetylase activity
KDB89_RS13210	COG0765	amino acid transport
KDB89_RS13215	COG1126	abc transporter atp-binding protein
KDB89_RS13220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KDB89_RS13230	COG1459	type II secretion system
KDB89_RS13255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KDB89_RS13275	COG2375	cellular response to nickel ion
KDB89_RS13280	COG2070	2-Nitropropane dioxygenase
KDB89_RS13285	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KDB89_RS13285	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KDB89_RS13300	COG3158	transport of potassium into the cell
KDB89_RS13310	COG0745	RESPONSE REGULATOR receiver
KDB89_RS13315	COG5002	protein histidine kinase activity
KDB89_RS13320	COG0439	Biotin carboxylase
KDB89_RS13340	COG1215	transferase activity, transferring glycosyl groups
KDB89_RS13365	COG4213	ABC transporter substrate-binding protein
KDB89_RS13375	COG4214	carbohydrate transport
KDB89_RS13380	COG0318	PFAM AMP-dependent synthetase and ligase
KDB89_RS13395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KDB89_RS13405	COG1064	alcohol dehydrogenase
KDB89_RS13410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KDB89_RS13730	COG4975	Glucose uptake
KDB89_RS13745	COG0395	ABC-type sugar transport system, permease component
KDB89_RS13750	COG1175	transmembrane transport
KDB89_RS13755	COG1653	transport
KDB89_RS13765	COG2186	Transcriptional regulator
KDB89_RS13775	COG5001	Diguanylate cyclase
KDB89_RS13830	COG4989	oxidoreductase activity
KDB89_RS13835	COG0534	Mate efflux family protein
KDB89_RS13860	COG0584	glycerophosphoryl diester phosphodiesterase
KDB89_RS13875	COG2154	pterin-4-alpha-carbinolamine dehydratase
KDB89_RS13880	COG1278	Cold shock
KDB89_RS13905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KDB89_RS13920	COG0583	DNA-binding transcription factor activity
KDB89_RS13970	COG0247	lactate metabolic process
KDB89_RS13975	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
KDB89_RS13980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KDB89_RS14005	COG0110	maltose O-acetyltransferase activity
KDB89_RS14010	COG2826	transposase and inactivated derivatives, IS30 family
KDB89_RS14035	COG0705	Rhomboid family
KDB89_RS14035	COG0457	Tetratricopeptide repeat
KDB89_RS14075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KDB89_RS14090	COG2115	Belongs to the xylose isomerase family
KDB89_RS14110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KDB89_RS14115	COG1012	belongs to the aldehyde dehydrogenase family
KDB89_RS14120	COG0673	inositol 2-dehydrogenase activity
KDB89_RS14125	COG1082	Xylose isomerase domain protein TIM barrel
KDB89_RS14130	COG0673	inositol 2-dehydrogenase activity
KDB89_RS14135	COG1172	Belongs to the binding-protein-dependent transport system permease family
KDB89_RS14140	COG1129	ABC transporter
KDB89_RS14150	COG1082	Xylose isomerase domain protein TIM barrel
KDB89_RS14155	COG3962	Belongs to the TPP enzyme family
KDB89_RS14160	COG3718	enzyme involved in inositol metabolism
KDB89_RS14165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KDB89_RS14170	COG2188	Transcriptional regulator
KDB89_RS14175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KDB89_RS14180	COG0673	inositol 2-dehydrogenase activity
KDB89_RS14195	COG1175	transmembrane transport
KDB89_RS14205	COG5426	von Willebrand factor, type A
KDB89_RS14220	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KDB89_RS14250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KDB89_RS14255	COG0490	domain, Protein
KDB89_RS14255	COG0471	metal ion transport
KDB89_RS14270	COG1309	transcriptional regulator
KDB89_RS14280	COG0346	lactoylglutathione lyase activity
KDB89_RS14300	COG0702	epimerase
KDB89_RS14310	COG0656	L-ascorbic acid biosynthetic process
KDB89_RS14320	COG2826	transposase and inactivated derivatives, IS30 family
KDB89_RS14330	COG1111	helicase
KDB89_RS14330	COG1205	dead DEAH box helicase
KDB89_RS14340	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KDB89_RS14355	COG1401	restriction endodeoxyribonuclease activity
KDB89_RS14405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KDB89_RS14410	COG1335	isochorismatase
KDB89_RS14420	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KDB89_RS14430	COG0492	ferredoxin-NADP+ reductase activity
KDB89_RS14435	COG3118	belongs to the thioredoxin family
KDB89_RS14450	COG1181	Belongs to the D-alanine--D-alanine ligase family
KDB89_RS14485	COG1472	Belongs to the glycosyl hydrolase 3 family
KDB89_RS14500	COG0357	Ribosomal RNA small subunit methyltransferase G
KDB89_RS14510	COG0706	membrane insertase activity
KDB89_RS14515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KDB89_RS14520	COG0594	ribonuclease P activity
KDB89_RS14525	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KDB89_RS14610	COG0561	phosphatase activity
KDB89_RS14650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KDB89_RS14655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KDB89_RS14655	COG3253	May function as heme-dependent peroxidase