locus-tag	class	description
BKM78_RS00020	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BKM78_RS00025	COG2884	Cell division ATP-binding protein ftsE
BKM78_RS00035	COG0739	heme binding
BKM78_RS00040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BKM78_RS00070	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BKM78_RS00120	COG1678	Uncharacterized ACR, COG1678
BKM78_RS00125	COG0745	RESPONSE REGULATOR receiver
BKM78_RS00130	COG5002	protein histidine kinase activity
BKM78_RS00135	COG5401	PFAM Sporulation and spore germination
BKM78_RS00140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BKM78_RS00145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BKM78_RS00150	COG0653	protein targeting
BKM78_RS00175	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BKM78_RS00185	COG0613	PHP domain protein
BKM78_RS00205	COG0631	protein serine/threonine phosphatase activity
BKM78_RS00220	COG0210	DNA helicase
BKM78_RS00235	COG0187	DNA topoisomerase II activity
BKM78_RS00240	COG1556	Lactate utilization protein
BKM78_RS00245	COG1139	Iron-sulfur cluster binding protein
BKM78_RS00250	COG0247	lactate metabolic process
BKM78_RS00255	COG1620	l-lactate permease
BKM78_RS00260	COG2186	Transcriptional regulator
BKM78_RS00270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BKM78_RS00295	COG1435	thymidine kinase activity
BKM78_RS00320	COG0756	dUTP diphosphatase activity
BKM78_RS00340	COG0569	domain protein
BKM78_RS00345	COG0531	amino acid
BKM78_RS00350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BKM78_RS00355	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BKM78_RS00365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BKM78_RS00430	COG0009	L-threonylcarbamoyladenylate synthase
BKM78_RS00435	COG0667	Aldo Keto reductase
BKM78_RS00455	COG2301	Belongs to the HpcH HpaI aldolase family
BKM78_RS00470	COG1295	ribonuclease BN
BKM78_RS00490	COG1716	ATPase activity
BKM78_RS00510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BKM78_RS00515	COG0438	transferase activity, transferring glycosyl groups
BKM78_RS00520	COG1560	Kdo2-lipid A biosynthetic process
BKM78_RS00530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BKM78_RS00545	COG5006	permease, DMT superfamily
BKM78_RS00560	COG1263	PTS System
BKM78_RS00560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BKM78_RS00560	COG2190	(PTS) system
BKM78_RS00565	COG0667	Aldo Keto reductase
BKM78_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
BKM78_RS00580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BKM78_RS00585	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BKM78_RS00600	COG3030	protein affecting phage T7 exclusion by the F plasmid
BKM78_RS00605	COG0463	Glycosyl transferase, family 2
BKM78_RS00615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BKM78_RS00620	COG2813	Specifically methylates the guanine in position
BKM78_RS00620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BKM78_RS00625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BKM78_RS00640	COG2873	o-acetylhomoserine
BKM78_RS00650	COG1760	l-serine dehydratase
BKM78_RS00655	COG1252	NADH dehydrogenase
BKM78_RS00670	COG0745	RESPONSE REGULATOR receiver
BKM78_RS00670	COG4191	Histidine kinase
BKM78_RS00670	COG2205	protein histidine kinase activity
BKM78_RS00675	COG3237	CsbD-like
BKM78_RS00690	COG1090	epimerase
BKM78_RS00710	COG1174	glycine betaine transport
BKM78_RS00715	COG1174	glycine betaine transport
BKM78_RS00720	COG1732	Glycine betaine
BKM78_RS00730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BKM78_RS00735	COG1278	Cold shock
BKM78_RS00740	COG2132	Multicopper oxidase
BKM78_RS00745	COG3685	Protein conserved in bacteria
BKM78_RS00755	COG3237	CsbD-like
BKM78_RS00760	COG1126	abc transporter atp-binding protein
BKM78_RS00765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BKM78_RS00770	COG0765	amino acid transport
BKM78_RS00775	COG0765	amino acid transport
BKM78_RS00795	COG1160	GTP binding
BKM78_RS00800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BKM78_RS00815	COG1410	methionine synthase
BKM78_RS00815	COG0646	methionine synthase
BKM78_RS00825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BKM78_RS00835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BKM78_RS00845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BKM78_RS00850	COG1758	RNA polymerase activity
BKM78_RS00855	COG0194	GDP metabolic process
BKM78_RS00865	COG0284	orotidine-5'-phosphate decarboxylase activity
BKM78_RS00870	COG0167	dihydroorotate dehydrogenase activity
BKM78_RS00875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BKM78_RS00880	COG0505	Belongs to the CarA family
BKM78_RS00885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BKM78_RS00890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BKM78_RS00895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BKM78_RS00900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BKM78_RS00905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BKM78_RS00910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BKM78_RS00920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BKM78_RS00925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BKM78_RS00945	COG2814	Major facilitator Superfamily
BKM78_RS00950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BKM78_RS00955	COG0124	histidyl-tRNA synthetase
BKM78_RS00960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BKM78_RS00965	COG1196	nuclear chromosome segregation
BKM78_RS00970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BKM78_RS00980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BKM78_RS00985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BKM78_RS00990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BKM78_RS00995	COG1862	Preprotein translocase
BKM78_RS01005	COG2255	four-way junction helicase activity
BKM78_RS01010	COG0632	four-way junction helicase activity
BKM78_RS01015	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BKM78_RS01020	COG0217	transcriptional regulatory protein
BKM78_RS01045	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BKM78_RS01050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BKM78_RS01055	COG0131	Imidazoleglycerol-phosphate dehydratase
BKM78_RS01060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BKM78_RS01065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BKM78_RS01075	COG0587	DNA-directed DNA polymerase activity
BKM78_RS01080	COG2985	domain, Protein
BKM78_RS01080	COG0569	domain protein
BKM78_RS01095	COG0070	glutamate synthase
BKM78_RS01095	COG0069	glutamate synthase activity
BKM78_RS01095	COG0067	glutamate synthase
BKM78_RS01100	COG0366	Alpha amylase catalytic
BKM78_RS01110	COG0159	tryptophan synthase activity
BKM78_RS01115	COG0133	tryptophan synthase activity
BKM78_RS01120	COG0134	indole-3-glycerol-phosphate synthase activity
BKM78_RS01140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BKM78_RS01195	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BKM78_RS01200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BKM78_RS01205	COG0154	amidase activity
BKM78_RS01210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BKM78_RS01230	COG0482	sulfurtransferase activity
BKM78_RS01250	COG0366	Alpha amylase catalytic
BKM78_RS01260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BKM78_RS01270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BKM78_RS01325	COG0596	Alpha beta hydrolase
BKM78_RS01345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BKM78_RS01350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BKM78_RS01355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BKM78_RS01360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BKM78_RS01365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BKM78_RS01370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BKM78_RS01380	COG0356	it plays a direct role in the translocation of protons across the membrane
BKM78_RS01390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BKM78_RS01400	COG2890	protein-(glutamine-N5) methyltransferase activity
BKM78_RS01405	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BKM78_RS01410	COG0254	rRNA binding
BKM78_RS01415	COG3547	Transposase (IS116 IS110 IS902 family)
BKM78_RS01425	COG0083	homoserine kinase activity
BKM78_RS01430	COG0460	homoserine dehydrogenase
BKM78_RS01455	COG0567	Dehydrogenase, E1 component
BKM78_RS01455	COG0508	dehydrogenase complex catalyzes the overall conversion of
BKM78_RS01465	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BKM78_RS01495	COG1595	DNA-templated transcription, initiation
BKM78_RS01500	COG2135	peptidase activity
BKM78_RS01510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BKM78_RS01515	COG1162	GTPase activity
BKM78_RS01520	COG0483	inositol monophosphate 1-phosphatase activity
BKM78_RS01525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BKM78_RS01535	COG0444	Belongs to the ABC transporter superfamily
BKM78_RS01540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BKM78_RS01550	COG0747	negative chemotaxis
BKM78_RS01555	COG4129	membrane
BKM78_RS01560	COG1609	Transcriptional regulator
BKM78_RS01565	COG0667	Aldo Keto reductase
BKM78_RS01585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BKM78_RS01585	COG1648	precorrin-2 dehydrogenase activity
BKM78_RS01590	COG0406	alpha-ribazole phosphatase activity
BKM78_RS01605	COG1492	cobalamin metabolic process
BKM78_RS01640	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BKM78_RS01670	COG0778	Nitroreductase
BKM78_RS01700	COG0667	Aldo Keto reductase
BKM78_RS01720	COG1615	UPF0182 protein
BKM78_RS01750	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BKM78_RS01760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BKM78_RS01770	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BKM78_RS01780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BKM78_RS01790	COG1946	Acyl-CoA thioesterase
BKM78_RS01795	COG1643	Atp-dependent helicase
BKM78_RS01825	COG0598	Magnesium transport protein CorA
BKM78_RS01830	COG0129	dihydroxy-acid dehydratase activity
BKM78_RS01840	COG1902	pentaerythritol trinitrate reductase activity
BKM78_RS01840	COG0446	pyridine nucleotide-disulphide oxidoreductase
BKM78_RS01850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BKM78_RS01855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BKM78_RS01865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BKM78_RS01875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BKM78_RS01880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BKM78_RS01885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BKM78_RS01895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BKM78_RS01900	COG2017	converts alpha-aldose to the beta-anomer
BKM78_RS01905	COG1418	mRNA catabolic process
BKM78_RS01910	COG2137	regulation of response to DNA damage stimulus
BKM78_RS01925	COG1349	DNA-binding transcription factor activity
BKM78_RS01930	COG1396	sequence-specific DNA binding
BKM78_RS01935	COG1058	Belongs to the CinA family
BKM78_RS01935	COG1546	Belongs to the CinA family
BKM78_RS01945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BKM78_RS01960	COG1181	Belongs to the D-alanine--D-alanine ligase family
BKM78_RS01995	COG3012	SEC-C Motif Domain Protein
BKM78_RS02005	COG0561	phosphatase activity
BKM78_RS02030	COG1104	cysteine desulfurase activity
BKM78_RS02035	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BKM78_RS02065	COG0666	response to abiotic stimulus
BKM78_RS02105	COG1335	isochorismatase
BKM78_RS02205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BKM78_RS02210	COG2376	Dihydroxyacetone kinase
BKM78_RS02245	COG2855	membrane
BKM78_RS02265	COG0066	3-isopropylmalate dehydratase activity
BKM78_RS02270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BKM78_RS02275	COG1414	Transcriptional regulator
BKM78_RS02295	COG1266	CAAX protease self-immunity
BKM78_RS02300	COG0179	Fumarylacetoacetate (FAA) hydrolase
BKM78_RS02305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BKM78_RS02310	COG0473	3-isopropylmalate dehydrogenase activity
BKM78_RS02315	COG1063	alcohol dehydrogenase
BKM78_RS02320	COG2213	PTS system mannitol-specific
BKM78_RS02320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BKM78_RS02325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BKM78_RS02330	COG0440	acetolactate synthase activity
BKM78_RS02355	COG0107	imidazoleglycerol-phosphate synthase activity
BKM78_RS02360	COG4581	dead DEAH box helicase
BKM78_RS02370	COG0805	protein transport
BKM78_RS02375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BKM78_RS02390	COG2378	regulation of single-species biofilm formation
BKM78_RS02395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BKM78_RS02400	COG0545	Peptidyl-prolyl cis-trans isomerase
BKM78_RS02410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BKM78_RS02440	COG0504	CTP synthase activity
BKM78_RS02445	COG0497	DNA recombination
BKM78_RS02450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BKM78_RS02500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BKM78_RS02505	COG0165	Argininosuccinate lyase
BKM78_RS02510	COG1438	arginine binding
BKM78_RS02520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BKM78_RS02525	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BKM78_RS02530	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BKM78_RS02555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BKM78_RS02560	COG2814	Major facilitator Superfamily
BKM78_RS02565	COG2124	cytochrome p450
BKM78_RS02580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BKM78_RS02580	COG0072	phenylalanine-tRNA ligase activity
BKM78_RS02585	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BKM78_RS02590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BKM78_RS02595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BKM78_RS02600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BKM78_RS02605	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BKM78_RS02625	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BKM78_RS02630	COG0140	phosphoribosyl-ATP diphosphatase activity
BKM78_RS02635	COG0215	cysteine-tRNA ligase activity
BKM78_RS02655	COG1968	undecaprenyl-diphosphatase activity
BKM78_RS02660	COG0667	Aldo Keto reductase
BKM78_RS02675	COG4974	Belongs to the 'phage' integrase family
BKM78_RS02680	COG1595	DNA-templated transcription, initiation
BKM78_RS02690	COG3547	Transposase (IS116 IS110 IS902 family)
BKM78_RS02715	COG3328	transposase activity
BKM78_RS02720	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BKM78_RS02825	COG0674	pyruvate-flavodoxin oxidoreductase activity
BKM78_RS02825	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BKM78_RS02825	COG1013	pyruvate-flavodoxin oxidoreductase activity
BKM78_RS02825	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BKM78_RS02835	COG0745	RESPONSE REGULATOR receiver
BKM78_RS02840	COG2205	protein histidine kinase activity
BKM78_RS02870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BKM78_RS02875	COG0785	Cytochrome C biogenesis protein
BKM78_RS02895	COG0745	RESPONSE REGULATOR receiver
BKM78_RS02900	COG2205	protein histidine kinase activity
BKM78_RS02925	COG2217	Heavy metal translocating P-type atpase
BKM78_RS02945	COG2217	Heavy metal translocating P-type atpase
BKM78_RS02950	COG1937	Protein conserved in bacteria
BKM78_RS02975	COG4172	Belongs to the ABC transporter superfamily
BKM78_RS02980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BKM78_RS02985	COG0601	transmembrane transport
BKM78_RS03050	COG0674	pyruvate-flavodoxin oxidoreductase activity
BKM78_RS03050	COG1013	pyruvate-flavodoxin oxidoreductase activity
BKM78_RS03050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BKM78_RS03050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BKM78_RS03065	COG0366	Alpha amylase catalytic
BKM78_RS03070	COG3588	fructose-bisphosphate aldolase
BKM78_RS03090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BKM78_RS03110	COG3845	ABC transporter
BKM78_RS03125	COG0758	DNA mediated transformation
BKM78_RS03135	COG0792	nuclease activity
BKM78_RS03145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BKM78_RS03155	COG0335	large ribosomal subunit rRNA binding
BKM78_RS03160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BKM78_RS03165	COG1053	succinate dehydrogenase
BKM78_RS03175	COG0336	Belongs to the RNA methyltransferase TrmD family
BKM78_RS03180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BKM78_RS03185	COG1837	Belongs to the UPF0109 family
BKM78_RS03190	COG0228	four-way junction DNA binding
BKM78_RS03215	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BKM78_RS03220	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BKM78_RS03225	COG4585	Histidine kinase
BKM78_RS03230	COG2197	response regulator
BKM78_RS03240	COG1131	(ABC) transporter
BKM78_RS03255	COG1196	nuclear chromosome segregation
BKM78_RS03265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BKM78_RS03270	COG0571	ribonuclease III activity
BKM78_RS03275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BKM78_RS03285	COG2801	Transposase and inactivated derivatives
BKM78_RS03290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BKM78_RS03295	COG0742	ribosomal rna small subunit methyltransferase
BKM78_RS03300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BKM78_RS03305	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BKM78_RS03310	COG1530	ribonuclease E activity
BKM78_RS03320	COG4868	Belongs to the UPF0371 family
BKM78_RS03330	COG0105	UTP biosynthetic process
BKM78_RS03340	COG0285	dihydrofolate synthase activity
BKM78_RS03350	COG0525	valine-tRNA ligase activity
BKM78_RS03355	COG1472	Belongs to the glycosyl hydrolase 3 family
BKM78_RS03365	COG0277	FAD linked oxidase domain protein
BKM78_RS03370	COG4946	Tricorn protease homolog
BKM78_RS03370	COG0793	Belongs to the peptidase S41A family
BKM78_RS03375	COG1793	dna ligase
BKM78_RS03380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BKM78_RS03385	COG0740	serine-type endopeptidase activity
BKM78_RS03390	COG0740	serine-type endopeptidase activity
BKM78_RS03395	COG0544	peptidyl-prolyl cis-trans isomerase activity
BKM78_RS03410	COG3550	peptidyl-serine autophosphorylation
BKM78_RS03455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BKM78_RS03470	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BKM78_RS03475	COG0540	Belongs to the ATCase OTCase family
BKM78_RS03480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BKM78_RS03505	COG1201	RNA secondary structure unwinding
BKM78_RS03510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BKM78_RS03530	COG0395	ABC-type sugar transport system, permease component
BKM78_RS03535	COG1175	transmembrane transport
BKM78_RS03545	COG3534	alpha-L-arabinofuranosidase
BKM78_RS03555	COG3507	Belongs to the glycosyl hydrolase 43 family
BKM78_RS03560	COG1609	Transcriptional regulator
BKM78_RS03565	COG2160	L-arabinose isomerase activity
BKM78_RS03585	COG0277	FAD linked oxidase domain protein
BKM78_RS03610	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BKM78_RS03635	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BKM78_RS03655	COG1028	Short-chain dehydrogenase reductase Sdr
BKM78_RS03670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BKM78_RS03675	COG1316	TRANSCRIPTIONal
BKM78_RS03690	COG1739	Uncharacterized protein family UPF0029
BKM78_RS03720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BKM78_RS03725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BKM78_RS03735	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BKM78_RS03740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BKM78_RS03745	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BKM78_RS03750	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BKM78_RS03760	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BKM78_RS03780	COG1714	RDD family
BKM78_RS03800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BKM78_RS03810	COG2835	tetraacyldisaccharide 4'-kinase activity
BKM78_RS03875	COG1316	TRANSCRIPTIONal
BKM78_RS03900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BKM78_RS03910	COG0424	maF-like protein
BKM78_RS03925	COG4770	biotin carboxylase activity
BKM78_RS03945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BKM78_RS03960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BKM78_RS03965	COG0328	RNA-DNA hybrid ribonuclease activity
BKM78_RS03975	COG2197	response regulator
BKM78_RS03990	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BKM78_RS04000	COG1079	Belongs to the binding-protein-dependent transport system permease family
BKM78_RS04005	COG4603	Belongs to the binding-protein-dependent transport system permease family
BKM78_RS04010	COG3845	ABC transporter
BKM78_RS04015	COG1744	ABC transporter substrate-binding protein PnrA-like
BKM78_RS04025	COG1253	flavin adenine dinucleotide binding
BKM78_RS04040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BKM78_RS04045	COG0039	L-malate dehydrogenase activity
BKM78_RS04060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BKM78_RS04065	COG0138	bifunctional purine biosynthesis protein purh
BKM78_RS04095	COG0045	succinate-CoA ligase (ADP-forming) activity
BKM78_RS04110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BKM78_RS04120	COG2261	transglycosylase associated protein
BKM78_RS04125	COG2197	response regulator
BKM78_RS04150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BKM78_RS04150	COG0519	Catalyzes the synthesis of GMP from XMP
BKM78_RS04160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BKM78_RS04170	COG0287	Prephenate dehydrogenase
BKM78_RS04170	COG1605	Chorismate mutase
BKM78_RS04175	COG0516	GMP reductase activity
BKM78_RS04185	COG0459	protein refolding
BKM78_RS04190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BKM78_RS04195	COG0110	maltose O-acetyltransferase activity
BKM78_RS04225	COG0747	negative chemotaxis
BKM78_RS04230	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BKM78_RS04245	COG0802	atpase or kinase
BKM78_RS04250	COG0513	Belongs to the DEAD box helicase family
BKM78_RS04260	COG1501	Belongs to the glycosyl hydrolase 31 family
BKM78_RS04270	COG2837	iron assimilation
BKM78_RS04280	COG0736	holo-[acyl-carrier-protein] synthase activity
BKM78_RS04285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BKM78_RS04290	COG1072	(Pantothenic acid kinase))
BKM78_RS04295	COG0006	proline dipeptidase activity
BKM78_RS04315	COG2301	Belongs to the HpcH HpaI aldolase family
BKM78_RS04320	COG2239	Acts as a magnesium transporter
BKM78_RS04340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BKM78_RS04355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BKM78_RS04365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BKM78_RS04370	COG0297	glycogen (starch) synthase activity
BKM78_RS04385	COG1611	Belongs to the LOG family
BKM78_RS04390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BKM78_RS04395	COG1305	Transglutaminase-like
BKM78_RS04410	COG2171	N-acyltransferase activity
BKM78_RS04420	COG1132	(ABC) transporter
BKM78_RS04425	COG1132	(ABC) transporter
BKM78_RS04435	COG0395	ABC-type sugar transport system, permease component
BKM78_RS04475	COG0616	signal peptide processing
BKM78_RS04485	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BKM78_RS04505	COG1335	isochorismatase
BKM78_RS04515	COG1045	serine acetyltransferase
BKM78_RS04525	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BKM78_RS04565	COG1362	aminopeptidase activity
BKM78_RS04570	COG1322	Protein conserved in bacteria
BKM78_RS04585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BKM78_RS04600	COG1722	exodeoxyribonuclease VII activity
BKM78_RS04610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BKM78_RS04620	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BKM78_RS04640	COG1331	Highly conserved protein containing a thioredoxin domain
BKM78_RS04655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BKM78_RS04670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BKM78_RS04685	COG2321	neutral zinc metallopeptidase
BKM78_RS04725	COG2268	Band 7 protein
BKM78_RS04745	COG0148	phosphopyruvate hydratase activity
BKM78_RS04765	COG0193	aminoacyl-tRNA hydrolase activity
BKM78_RS04780	COG3250	beta-galactosidase activity
BKM78_RS04790	COG1175	transmembrane transport
BKM78_RS04795	COG0395	ABC-type sugar transport system, permease component
BKM78_RS04800	COG1609	Transcriptional regulator
BKM78_RS04810	COG4806	L-rhamnose isomerase
BKM78_RS04810	COG1070	Carbohydrate kinase
BKM78_RS04825	COG1136	(ABC) transporter
BKM78_RS04835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BKM78_RS04840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BKM78_RS04850	COG1609	Transcriptional regulator
BKM78_RS04860	COG0671	phosphoesterase, PA-phosphatase related
BKM78_RS04900	COG2818	Glycosylase
BKM78_RS04910	COG1309	transcriptional regulator
BKM78_RS04920	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BKM78_RS04925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BKM78_RS04930	COG0084	hydrolase, TatD family'
BKM78_RS04950	COG2233	PERMEase
BKM78_RS04955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BKM78_RS04960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BKM78_RS05015	COG1970	mechanosensitive ion channel activity
BKM78_RS05065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BKM78_RS05070	COG2146	nitrite reductase [NAD(P)H] activity
BKM78_RS05070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BKM78_RS05095	COG0167	dihydroorotate dehydrogenase activity
BKM78_RS05100	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BKM78_RS05100	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BKM78_RS05100	COG0674	pyruvate-flavodoxin oxidoreductase activity
BKM78_RS05100	COG1013	pyruvate-flavodoxin oxidoreductase activity
BKM78_RS05105	COG0493	'glutamate synthase
BKM78_RS05125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BKM78_RS05140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BKM78_RS05145	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BKM78_RS05160	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BKM78_RS05165	COG2252	PERMEase
BKM78_RS05175	COG1278	Cold shock
BKM78_RS05180	COG0363	glucosamine-6-phosphate deaminase activity
BKM78_RS05190	COG1051	belongs to the nudix hydrolase family
BKM78_RS05240	COG3842	ATPase activity
BKM78_RS05245	COG0626	cystathionine gamma-synthase activity
BKM78_RS05255	COG2226	methyltransferase
BKM78_RS05260	COG0215	cysteine-tRNA ligase activity
BKM78_RS05265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BKM78_RS05270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BKM78_RS05275	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BKM78_RS05280	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BKM78_RS05285	COG1329	Transcriptional regulator
BKM78_RS05300	COG5002	protein histidine kinase activity
BKM78_RS05310	COG0588	phosphoglycerate mutase activity
BKM78_RS05325	COG1454	alcohol dehydrogenase
BKM78_RS05355	COG1472	Belongs to the glycosyl hydrolase 3 family
BKM78_RS05375	COG3279	Response regulator of the LytR AlgR family
BKM78_RS05385	COG1472	Belongs to the glycosyl hydrolase 3 family
BKM78_RS05415	COG1028	Short-chain dehydrogenase reductase Sdr
BKM78_RS05425	COG0022	dehydrogenase e1 component
BKM78_RS05430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BKM78_RS05435	COG0508	dehydrogenase complex catalyzes the overall conversion of
BKM78_RS05440	COG1349	DNA-binding transcription factor activity
BKM78_RS05455	COG1609	Transcriptional regulator
BKM78_RS05465	COG1172	Belongs to the binding-protein-dependent transport system permease family
BKM78_RS05485	COG1028	Short-chain dehydrogenase reductase Sdr
BKM78_RS05490	COG1072	(Pantothenic acid kinase))
BKM78_RS05495	COG0246	Mannitol dehydrogenase
BKM78_RS05505	COG0561	phosphatase activity
BKM78_RS05530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BKM78_RS05535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BKM78_RS05540	COG0730	response to heat
BKM78_RS05545	COG0640	Transcriptional regulator
BKM78_RS05570	COG1609	Transcriptional regulator
BKM78_RS05580	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
BKM78_RS05590	COG1172	Belongs to the binding-protein-dependent transport system permease family
BKM78_RS05605	COG0191	fructose-bisphosphate aldolase activity
BKM78_RS05630	COG2353	YceI-like domain
BKM78_RS05635	COG1704	LemA family
BKM78_RS05650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BKM78_RS05655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BKM78_RS05665	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BKM78_RS05675	COG1797	cobyrinic acid a,c-diamide synthase activity
BKM78_RS05680	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BKM78_RS05700	COG0310	cobalt ion transport
BKM78_RS05725	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BKM78_RS05730	COG1834	amidinotransferase
BKM78_RS05735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BKM78_RS05760	COG0514	ATP-dependent DNA helicase (RecQ)
BKM78_RS05765	COG1492	cobalamin metabolic process
BKM78_RS05770	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BKM78_RS05800	COG1253	flavin adenine dinucleotide binding
BKM78_RS05810	COG0640	Transcriptional regulator
BKM78_RS05820	COG2217	Heavy metal translocating P-type atpase
BKM78_RS05830	COG1609	Transcriptional regulator
BKM78_RS05845	COG3250	beta-galactosidase activity
BKM78_RS05850	COG1609	Transcriptional regulator
BKM78_RS05860	COG1175	transmembrane transport
BKM78_RS05865	COG0395	ABC-type sugar transport system, permease component
BKM78_RS05895	COG0714	Associated with various cellular activities
BKM78_RS05945	COG2133	pyrroloquinoline quinone binding
BKM78_RS05950	COG0259	pyridoxamine-phosphate oxidase activity
BKM78_RS05965	COG0542	response to heat
BKM78_RS05970	COG0366	Alpha amylase catalytic
BKM78_RS05995	COG1063	alcohol dehydrogenase
BKM78_RS06000	COG0156	8-amino-7-oxononanoate synthase activity
BKM78_RS06015	COG0352	thiamine-phosphate diphosphorylase activity
BKM78_RS06015	COG0351	phosphomethylpyrimidine kinase
BKM78_RS06015	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BKM78_RS06020	COG0351	phosphomethylpyrimidine kinase
BKM78_RS06025	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BKM78_RS06025	COG0351	phosphomethylpyrimidine kinase
BKM78_RS06025	COG0352	thiamine-phosphate diphosphorylase activity
BKM78_RS06030	COG0058	SHG alpha-glucan phosphorylase activity
BKM78_RS06035	COG1120	ATPase activity
BKM78_RS06040	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BKM78_RS06045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BKM78_RS06065	COG0789	Transcriptional regulator
BKM78_RS06070	COG0484	heat shock protein binding
BKM78_RS06075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BKM78_RS06090	COG0189	ligase activity
BKM78_RS06105	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BKM78_RS06130	COG1252	NADH dehydrogenase
BKM78_RS06135	COG2259	Doxx family
BKM78_RS06140	COG0745	RESPONSE REGULATOR receiver
BKM78_RS06145	COG2205	protein histidine kinase activity
BKM78_RS06150	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BKM78_RS06160	COG0717	Belongs to the dCTP deaminase family
BKM78_RS06175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BKM78_RS06185	COG3132	Protein of unknown function, DUF480
BKM78_RS06195	COG1653	transport
BKM78_RS06200	COG0433	COG0433 Predicted ATPase
BKM78_RS06235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BKM78_RS06245	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BKM78_RS06250	COG0584	glycerophosphoryl diester phosphodiesterase
BKM78_RS06255	COG3951	Flagellar rod assembly protein muramidase FlgJ
BKM78_RS06255	COG1705	Flagellar rod assembly protein muramidase FlgJ
BKM78_RS06265	COG2801	Transposase and inactivated derivatives
BKM78_RS06275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BKM78_RS06285	COG1316	TRANSCRIPTIONal
BKM78_RS06305	COG1609	Transcriptional regulator
BKM78_RS06310	COG1879	ABC-type sugar transport system periplasmic component
BKM78_RS06315	COG1129	ABC transporter
BKM78_RS06325	COG1172	Belongs to the binding-protein-dependent transport system permease family
BKM78_RS06330	COG1082	Xylose isomerase domain protein TIM barrel
BKM78_RS06345	COG0564	pseudouridine synthase activity
BKM78_RS06360	COG0604	alcohol dehydrogenase
BKM78_RS06375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BKM78_RS06435	COG0137	argininosuccinate synthase activity
BKM78_RS06455	COG0561	phosphatase activity
BKM78_RS06460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BKM78_RS06485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BKM78_RS06490	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BKM78_RS06500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BKM78_RS06505	COG0508	dehydrogenase complex catalyzes the overall conversion of
BKM78_RS06510	COG0022	dehydrogenase e1 component
BKM78_RS06520	COG0737	Belongs to the 5'-nucleotidase family
BKM78_RS06525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BKM78_RS06565	COG3328	transposase activity
BKM78_RS06575	COG4974	Belongs to the 'phage' integrase family
BKM78_RS06600	COG1120	ATPase activity
BKM78_RS06615	COG2205	protein histidine kinase activity
BKM78_RS06620	COG0745	RESPONSE REGULATOR receiver
BKM78_RS06630	COG1131	(ABC) transporter
BKM78_RS06640	COG2815	serine threonine protein kinase
BKM78_RS06640	COG0515	serine threonine protein kinase
BKM78_RS06660	COG1595	DNA-templated transcription, initiation
BKM78_RS06665	COG0318	PFAM AMP-dependent synthetase and ligase
BKM78_RS06675	COG3360	Dodecin
BKM78_RS06685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BKM78_RS06695	COG0438	transferase activity, transferring glycosyl groups
BKM78_RS06715	COG3250	beta-galactosidase activity
BKM78_RS06720	COG2211	Major facilitator Superfamily
BKM78_RS06725	COG1609	Transcriptional regulator
BKM78_RS06735	COG0277	FAD linked oxidase domain protein
BKM78_RS06735	COG0247	lactate metabolic process
BKM78_RS06750	COG1850	ribulose-bisphosphate carboxylase activity
BKM78_RS06765	COG3250	beta-galactosidase activity
BKM78_RS06775	COG0395	ABC-type sugar transport system, permease component
BKM78_RS06780	COG1175	transmembrane transport
BKM78_RS06800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BKM78_RS06805	COG1879	ABC-type sugar transport system periplasmic component
BKM78_RS06810	COG1172	Belongs to the binding-protein-dependent transport system permease family
BKM78_RS06825	COG3958	Transketolase
BKM78_RS06830	COG3959	Transketolase, thiamine diphosphate binding domain
BKM78_RS06835	COG1082	Xylose isomerase domain protein TIM barrel
BKM78_RS06840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BKM78_RS06845	COG1869	D-ribose catabolic process
BKM78_RS06855	COG0745	RESPONSE REGULATOR receiver
BKM78_RS06860	COG5002	protein histidine kinase activity
BKM78_RS06880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BKM78_RS06900	COG0745	RESPONSE REGULATOR receiver
BKM78_RS06930	COG3842	ATPase activity
BKM78_RS06955	COG1819	glycosyl
BKM78_RS06970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BKM78_RS06975	COG0673	inositol 2-dehydrogenase activity
BKM78_RS07000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BKM78_RS07010	COG0360	Binds together with S18 to 16S ribosomal RNA
BKM78_RS07020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BKM78_RS07025	COG1022	Amp-dependent synthetase and ligase
BKM78_RS07035	COG0673	inositol 2-dehydrogenase activity
BKM78_RS07040	COG1609	Transcriptional regulator
BKM78_RS07050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BKM78_RS07050	COG2111	Na H antiporter
BKM78_RS07055	COG1006	Multisubunit Na H antiporter MnhC subunit
BKM78_RS07060	COG0651	ATP synthesis coupled electron transport
BKM78_RS07080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BKM78_RS07085	COG1404	Belongs to the peptidase S8 family
BKM78_RS07095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BKM78_RS07100	COG0300	oxidoreductase activity
BKM78_RS07115	COG3022	response to hydroperoxide
BKM78_RS07120	COG0733	neurotransmitter:sodium symporter activity
BKM78_RS07130	COG0574	Belongs to the PEP-utilizing enzyme family
BKM78_RS07130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BKM78_RS07135	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BKM78_RS07155	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BKM78_RS07195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BKM78_RS07200	COG0668	transmembrane transport
BKM78_RS07225	COG1793	dna ligase
BKM78_RS07230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BKM78_RS07235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BKM78_RS07245	COG2409	Drug exporters of the RND superfamily
BKM78_RS07255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BKM78_RS07260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BKM78_RS07270	COG2197	response regulator
BKM78_RS07295	COG2076	Multidrug Resistance protein
BKM78_RS07320	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BKM78_RS07325	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BKM78_RS07340	COG2354	Protein conserved in bacteria
BKM78_RS07375	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
BKM78_RS07375	COG1672	PFAM Archaeal ATPase
BKM78_RS07385	COG0723	plastoquinol--plastocyanin reductase activity
BKM78_RS07455	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BKM78_RS07460	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BKM78_RS07470	COG2801	Transposase and inactivated derivatives
BKM78_RS07470	COG3415	Transposase
BKM78_RS07480	COG3250	beta-galactosidase activity
BKM78_RS07500	COG1609	Transcriptional regulator
BKM78_RS07540	COG1472	Belongs to the glycosyl hydrolase 3 family
BKM78_RS07550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BKM78_RS07550	COG0426	domain, Protein
BKM78_RS07565	COG1304	FMN binding
BKM78_RS07570	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BKM78_RS07580	COG0666	response to abiotic stimulus
BKM78_RS07585	COG0549	Belongs to the carbamate kinase family
BKM78_RS07590	COG1802	Transcriptional regulator
BKM78_RS07605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BKM78_RS07620	COG3415	Transposase
BKM78_RS07620	COG2801	Transposase and inactivated derivatives
BKM78_RS07630	COG0667	Aldo Keto reductase
BKM78_RS07640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BKM78_RS07645	COG3547	Transposase (IS116 IS110 IS902 family)
BKM78_RS07665	COG3833	ABC-type maltose transport systems, permease component
BKM78_RS07670	COG1175	transmembrane transport
BKM78_RS07680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BKM78_RS07700	COG1082	Xylose isomerase domain protein TIM barrel
BKM78_RS07705	COG1082	Xylose isomerase domain protein TIM barrel
BKM78_RS07710	COG0673	inositol 2-dehydrogenase activity
BKM78_RS07715	COG1172	Belongs to the binding-protein-dependent transport system permease family
BKM78_RS07735	COG3693	PFAM glycoside hydrolase, family 10
BKM78_RS07755	COG1752	Esterase of the alpha-beta hydrolase superfamily
BKM78_RS07765	COG1295	ribonuclease BN
BKM78_RS07810	COG2197	response regulator
BKM78_RS07835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BKM78_RS07840	COG1116	anion transmembrane transporter activity
BKM78_RS07860	COG1609	Transcriptional regulator
BKM78_RS07875	COG1309	transcriptional regulator
BKM78_RS07885	COG1028	Short-chain dehydrogenase reductase Sdr
BKM78_RS07895	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BKM78_RS07900	COG1850	ribulose-bisphosphate carboxylase activity
BKM78_RS07915	COG3266	domain, Protein
BKM78_RS07920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BKM78_RS07935	COG0739	heme binding
BKM78_RS07945	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
BKM78_RS07950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BKM78_RS07955	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BKM78_RS07960	COG0592	DNA-directed DNA polymerase activity
BKM78_RS07965	COG0577	efflux transmembrane transporter activity
BKM78_RS07970	COG1136	(ABC) transporter
BKM78_RS07970	COG0577	efflux transmembrane transporter activity
BKM78_RS07980	COG1937	Protein conserved in bacteria
BKM78_RS07985	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BKM78_RS07990	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BKM78_RS07995	COG0594	ribonuclease P activity
BKM78_RS08000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BKM78_RS08005	COG0706	membrane insertase activity
BKM78_RS08015	COG0357	Ribosomal RNA small subunit methyltransferase G
BKM78_RS08040	COG1181	Belongs to the D-alanine--D-alanine ligase family
BKM78_RS08055	COG3118	belongs to the thioredoxin family
BKM78_RS08060	COG0492	ferredoxin-NADP+ reductase activity
BKM78_RS08065	COG1024	Enoyl-CoA hydratase
BKM78_RS08100	COG1192	Involved in chromosome partitioning
BKM78_RS08130	COG0366	Alpha amylase catalytic
BKM78_RS08135	COG0531	amino acid
BKM78_RS08210	COG3415	Transposase
BKM78_RS08210	COG2801	Transposase and inactivated derivatives
BKM78_RS08215	COG2409	Drug exporters of the RND superfamily
BKM78_RS08255	COG1129	ABC transporter
BKM78_RS08265	COG1609	Transcriptional regulator
BKM78_RS08270	COG2815	serine threonine protein kinase
BKM78_RS08270	COG0515	serine threonine protein kinase
BKM78_RS08285	COG1129	ABC transporter
BKM78_RS08300	COG1879	ABC-type sugar transport system periplasmic component
BKM78_RS08305	COG0247	lactate metabolic process
BKM78_RS08310	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
BKM78_RS08315	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BKM78_RS08380	COG3559	Exporter of polyketide antibiotics
BKM78_RS08385	COG1131	(ABC) transporter
BKM78_RS08390	COG1309	transcriptional regulator
BKM78_RS08395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BKM78_RS08400	COG1105	Belongs to the carbohydrate kinase PfkB family
BKM78_RS08410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BKM78_RS08430	COG2186	Transcriptional regulator
BKM78_RS08440	COG2084	Dehydrogenase
BKM78_RS08445	COG2610	gluconate transmembrane transporter activity
BKM78_RS08485	COG0667	Aldo Keto reductase
BKM78_RS08490	COG3655	Transcriptional regulator
BKM78_RS08505	COG1803	Methylglyoxal synthase
BKM78_RS08510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BKM78_RS08515	COG1940	carbohydrate kinase activity
BKM78_RS08525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BKM78_RS08530	COG0667	Aldo Keto reductase
BKM78_RS08555	COG0705	Rhomboid family
BKM78_RS08555	COG0457	Tetratricopeptide repeat
BKM78_RS08620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BKM78_RS08645	COG4213	ABC transporter substrate-binding protein
BKM78_RS08650	COG4214	carbohydrate transport
BKM78_RS08660	COG4213	ABC transporter substrate-binding protein
BKM78_RS08665	COG0535	radical SAM domain protein
BKM78_RS08695	COG1132	(ABC) transporter
BKM78_RS08700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BKM78_RS08720	COG0439	Biotin carboxylase
BKM78_RS08725	COG2910	NAD(P)H-binding
BKM78_RS08730	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BKM78_RS08730	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BKM78_RS08745	COG0488	(ABC) transporter
BKM78_RS08750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BKM78_RS08755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BKM78_RS08765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BKM78_RS08780	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BKM78_RS08795	COG0673	inositol 2-dehydrogenase activity
BKM78_RS08820	COG1597	lipid kinase activity
BKM78_RS08845	COG0686	Belongs to the AlaDH PNT family
BKM78_RS08850	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BKM78_RS08855	COG4209	transmembrane transport
BKM78_RS08860	COG0395	ABC-type sugar transport system, permease component
BKM78_RS08875	COG3507	Belongs to the glycosyl hydrolase 43 family
BKM78_RS08880	COG1472	Belongs to the glycosyl hydrolase 3 family
BKM78_RS08885	COG1609	Transcriptional regulator
BKM78_RS08890	COG1501	Belongs to the glycosyl hydrolase 31 family
BKM78_RS08900	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BKM78_RS08910	COG0438	transferase activity, transferring glycosyl groups
BKM78_RS08920	COG1134	teichoic acid transport
BKM78_RS08955	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BKM78_RS08965	COG3328	transposase activity
BKM78_RS08995	COG0305	Participates in initiation and elongation during chromosome replication
BKM78_RS09000	COG1937	Protein conserved in bacteria
BKM78_RS09005	COG2608	mercury ion transmembrane transporter activity
BKM78_RS09015	COG0114	fumarate hydratase activity
BKM78_RS09025	COG1929	Belongs to the glycerate kinase type-1 family
BKM78_RS09030	COG4988	ABC transporter
BKM78_RS09040	COG1294	oxidase, subunit
BKM78_RS09045	COG1271	oxidase subunit
BKM78_RS09055	COG2326	polyphosphate kinase activity
BKM78_RS09065	COG2514	catechol 2,3-dioxygenase activity
BKM78_RS09070	COG1940	carbohydrate kinase activity
BKM78_RS09075	COG2115	Belongs to the xylose isomerase family
BKM78_RS09080	COG1070	Carbohydrate kinase
BKM78_RS09105	COG0662	Cupin 2, conserved barrel domain protein
BKM78_RS09135	COG3250	beta-galactosidase activity
BKM78_RS09145	COG0531	amino acid
BKM78_RS09160	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BKM78_RS09165	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BKM78_RS09180	COG0395	ABC-type sugar transport system, permease component
BKM78_RS09185	COG1175	transmembrane transport
BKM78_RS09200	COG1609	Transcriptional regulator
BKM78_RS09230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BKM78_RS09250	COG0515	serine threonine protein kinase
BKM78_RS09255	COG0768	penicillin binding
BKM78_RS09275	COG1716	ATPase activity
BKM78_RS09295	COG0590	tRNA wobble adenosine to inosine editing
BKM78_RS09300	COG1063	alcohol dehydrogenase
BKM78_RS09305	COG2390	Transcriptional regulator
BKM78_RS09315	COG1902	pentaerythritol trinitrate reductase activity
BKM78_RS09335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BKM78_RS09350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BKM78_RS09365	COG3718	enzyme involved in inositol metabolism
BKM78_RS09370	COG3962	Belongs to the TPP enzyme family
BKM78_RS09380	COG0673	inositol 2-dehydrogenase activity
BKM78_RS09385	COG1950	PFAM Membrane protein of
BKM78_RS09400	COG0673	inositol 2-dehydrogenase activity
BKM78_RS09405	COG0406	alpha-ribazole phosphatase activity
BKM78_RS09410	COG1172	Belongs to the binding-protein-dependent transport system permease family
BKM78_RS09415	COG1129	ABC transporter
BKM78_RS09425	COG1082	Xylose isomerase domain protein TIM barrel
BKM78_RS09430	COG0673	inositol 2-dehydrogenase activity
BKM78_RS09445	COG1175	transmembrane transport
BKM78_RS09450	COG0395	ABC-type sugar transport system, permease component
BKM78_RS09460	COG0438	transferase activity, transferring glycosyl groups
BKM78_RS09465	COG2186	Transcriptional regulator
BKM78_RS09470	COG3265	gluconokinase activity
BKM78_RS09480	COG1472	Belongs to the glycosyl hydrolase 3 family
BKM78_RS09490	COG1175	transmembrane transport
BKM78_RS09505	COG4989	oxidoreductase activity
BKM78_RS09545	COG1204	response to ionizing radiation
BKM78_RS09570	COG3328	transposase activity
BKM78_RS09585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BKM78_RS09585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BKM78_RS09590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BKM78_RS09605	COG0561	phosphatase activity
BKM78_RS09610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BKM78_RS09635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BKM78_RS09640	COG0505	Belongs to the CarA family
BKM78_RS09655	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BKM78_RS09660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BKM78_RS09720	COG3547	Transposase (IS116 IS110 IS902 family)
BKM78_RS09765	COG1131	(ABC) transporter
BKM78_RS09795	COG0693	protein deglycase activity
BKM78_RS09845	COG0386	Belongs to the glutathione peroxidase family
BKM78_RS09855	COG1609	Transcriptional regulator
BKM78_RS09865	COG1175	transmembrane transport
BKM78_RS09870	COG0395	ABC-type sugar transport system, permease component
BKM78_RS09875	COG1653	transport
BKM78_RS09905	COG2186	Transcriptional regulator
BKM78_RS09910	COG0747	negative chemotaxis
BKM78_RS09920	COG0444	Belongs to the ABC transporter superfamily
BKM78_RS09930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BKM78_RS09935	COG1940	carbohydrate kinase activity
BKM78_RS09940	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BKM78_RS09945	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BKM78_RS09950	COG3833	ABC-type maltose transport systems, permease component
BKM78_RS09955	COG1175	transmembrane transport
BKM78_RS09990	COG1621	beta-fructofuranosidase activity
BKM78_RS10000	COG0395	ABC-type sugar transport system, permease component
BKM78_RS10005	COG4209	transmembrane transport
BKM78_RS10010	COG1609	Transcriptional regulator
BKM78_RS10030	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BKM78_RS10035	COG2409	Drug exporters of the RND superfamily
BKM78_RS10045	COG0708	Exodeoxyribonuclease III
BKM78_RS10055	COG0515	serine threonine protein kinase
BKM78_RS10065	COG1609	Transcriptional regulator
BKM78_RS10075	COG4209	transmembrane transport
BKM78_RS10080	COG0395	ABC-type sugar transport system, permease component
BKM78_RS10110	COG0477	Major facilitator Superfamily
BKM78_RS10130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BKM78_RS10145	COG1316	TRANSCRIPTIONal
BKM78_RS10150	COG0477	Major facilitator Superfamily
BKM78_RS10175	COG0166	Belongs to the GPI family
BKM78_RS10185	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BKM78_RS10210	COG0018	arginyl-trna synthetase
BKM78_RS10215	COG1940	carbohydrate kinase activity
BKM78_RS10235	COG0205	6-phosphofructokinase activity
BKM78_RS10240	COG0277	FAD linked oxidase domain protein
BKM78_RS10260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BKM78_RS10270	COG0546	phosphoglycolate phosphatase activity
BKM78_RS10275	COG1464	Belongs to the NlpA lipoprotein family
BKM78_RS10280	COG2011	ABC-type metal ion transport system permease component
BKM78_RS10285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BKM78_RS10305	COG1793	dna ligase
BKM78_RS10310	COG1473	amidohydrolase
BKM78_RS10315	COG2095	MarC family integral membrane protein
BKM78_RS10330	COG0560	Phosphoserine phosphatase
BKM78_RS10330	COG3830	Belongs to the UPF0237 family
BKM78_RS10335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BKM78_RS10340	COG2813	Specifically methylates the guanine in position
BKM78_RS10365	COG1115	amino acid carrier protein
BKM78_RS10385	COG2056	Na+-H+ antiporter family
BKM78_RS10405	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BKM78_RS10410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BKM78_RS10420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BKM78_RS10430	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BKM78_RS10440	COG1131	(ABC) transporter
BKM78_RS10455	COG0659	secondary active sulfate transmembrane transporter activity
BKM78_RS10460	COG0281	malic enzyme
BKM78_RS10465	COG0647	UMP catabolic process
BKM78_RS10470	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BKM78_RS10490	COG3732	PTS system glucitol sorbitol-specific
BKM78_RS10500	COG0371	Dehydrogenase
BKM78_RS10505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BKM78_RS10510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BKM78_RS10515	COG0673	inositol 2-dehydrogenase activity
BKM78_RS10530	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BKM78_RS10550	COG1408	metallophosphoesterase
BKM78_RS10555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BKM78_RS10615	COG0726	polysaccharide deacetylase
BKM78_RS10620	COG1205	dead DEAH box helicase
BKM78_RS10620	COG1111	helicase
BKM78_RS10640	COG0667	Aldo Keto reductase
BKM78_RS10650	COG1754	DNA topoisomerase type I activity
BKM78_RS10650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BKM78_RS10660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BKM78_RS10665	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BKM78_RS10675	COG1774	PSP1 C-terminal conserved region
BKM78_RS10685	COG2801	Transposase and inactivated derivatives
BKM78_RS10690	COG2801	Transposase and inactivated derivatives
BKM78_RS10700	COG3458	cephalosporin-C deacetylase activity
BKM78_RS10710	COG1231	oxidoreductase activity
BKM78_RS10740	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BKM78_RS10755	COG0037	tRNA processing
BKM78_RS10770	COG0302	gtp cyclohydrolase
BKM78_RS10775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BKM78_RS10785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BKM78_RS10800	COG0649	NAD binding
BKM78_RS10820	COG2149	membrane
BKM78_RS10825	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BKM78_RS10830	COG3842	ATPase activity
BKM78_RS10845	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BKM78_RS10850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BKM78_RS10865	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BKM78_RS10875	COG1082	Xylose isomerase domain protein TIM barrel
BKM78_RS10890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BKM78_RS10895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BKM78_RS10910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BKM78_RS10930	COG0406	alpha-ribazole phosphatase activity
BKM78_RS10940	COG0785	Cytochrome C biogenesis protein
BKM78_RS10950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BKM78_RS10960	COG0300	oxidoreductase activity
BKM78_RS10980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BKM78_RS11000	COG3328	transposase activity
BKM78_RS11030	COG2376	Dihydroxyacetone kinase
BKM78_RS11040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BKM78_RS11050	COG1609	Transcriptional regulator
BKM78_RS11055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BKM78_RS11060	COG3959	Transketolase, thiamine diphosphate binding domain
BKM78_RS11065	COG0698	ribose 5-phosphate isomerase
BKM78_RS11070	COG0647	UMP catabolic process
BKM78_RS11085	COG3328	transposase activity
BKM78_RS11100	COG0745	RESPONSE REGULATOR receiver
BKM78_RS11110	COG1490	D-aminoacyl-tRNA deacylase activity
BKM78_RS11115	COG3485	protocatechuate 3,4-dioxygenase
BKM78_RS11120	COG0354	folic acid binding
BKM78_RS11135	COG2326	polyphosphate kinase activity
BKM78_RS11140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BKM78_RS11155	COG1217	gtp-binding protein TYPA
BKM78_RS11180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BKM78_RS11180	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BKM78_RS11180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BKM78_RS11185	COG1461	Dihydroxyacetone kinase
BKM78_RS11190	COG2376	Dihydroxyacetone kinase
BKM78_RS11195	COG3118	belongs to the thioredoxin family
BKM78_RS11200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BKM78_RS11205	COG0151	Belongs to the GarS family
BKM78_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
BKM78_RS11240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BKM78_RS11260	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BKM78_RS11265	COG0175	sulfate reduction
BKM78_RS11285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BKM78_RS11295	COG2094	Belongs to the DNA glycosylase MPG family
BKM78_RS11300	COG0436	Aminotransferase
BKM78_RS11315	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BKM78_RS11320	COG0047	phosphoribosylformylglycinamidine synthase activity
BKM78_RS11325	COG2827	Endonuclease containing a URI domain
BKM78_RS11335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BKM78_RS11340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BKM78_RS11350	COG3415	Transposase
BKM78_RS11350	COG2801	Transposase and inactivated derivatives
BKM78_RS11355	COG1051	belongs to the nudix hydrolase family
BKM78_RS11360	COG1027	Aspartate ammonia-lyase
BKM78_RS11365	COG1024	Enoyl-CoA hydratase
BKM78_RS11375	COG2234	aminopeptidase activity
BKM78_RS11385	COG0366	Alpha amylase catalytic
BKM78_RS11405	COG3833	ABC-type maltose transport systems, permease component
BKM78_RS11415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BKM78_RS11430	COG1140	nitrate reductase beta subunit
BKM78_RS11455	COG0314	molybdopterin synthase activity
BKM78_RS11470	COG0315	cyclic pyranopterin monophosphate synthase activity
BKM78_RS11475	COG0315	cyclic pyranopterin monophosphate synthase activity
BKM78_RS11475	COG0521	Mo-molybdopterin cofactor biosynthetic process
BKM78_RS11500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BKM78_RS11505	COG0058	SHG alpha-glucan phosphorylase activity
BKM78_RS11515	COG2801	Transposase and inactivated derivatives
BKM78_RS11520	COG4154	Belongs to the RbsD FucU family
BKM78_RS11530	COG1129	ABC transporter
BKM78_RS11535	COG1172	Belongs to the binding-protein-dependent transport system permease family
BKM78_RS11540	COG1879	ABC-type sugar transport system periplasmic component
BKM78_RS11555	COG2838	Isocitrate dehydrogenase
BKM78_RS11615	COG2116	formate transmembrane transporter activity
BKM78_RS11620	COG0751	glycine-tRNA ligase activity
BKM78_RS11620	COG0752	glycyl-tRNA synthetase alpha subunit
BKM78_RS11625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BKM78_RS11630	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BKM78_RS11640	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BKM78_RS11650	COG1461	Dihydroxyacetone kinase
BKM78_RS11670	COG4948	Mandelate Racemase Muconate Lactonizing
BKM78_RS11675	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BKM78_RS11685	COG2226	methyltransferase
BKM78_RS11705	COG1169	isochorismate synthase
BKM78_RS11710	COG0644	oxidoreductase
BKM78_RS11720	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BKM78_RS11725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BKM78_RS11730	COG0649	NAD binding
BKM78_RS11740	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BKM78_RS11745	COG1034	ATP synthesis coupled electron transport
BKM78_RS11750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BKM78_RS11755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BKM78_RS11780	COG1007	ATP synthesis coupled electron transport
BKM78_RS11785	COG0142	geranyltranstransferase activity
BKM78_RS11790	COG3590	peptidase
BKM78_RS11795	COG1013	pyruvate-flavodoxin oxidoreductase activity
BKM78_RS11800	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BKM78_RS11800	COG0674	pyruvate-flavodoxin oxidoreductase activity
BKM78_RS11805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BKM78_RS11810	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BKM78_RS11815	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BKM78_RS11830	COG1666	GTP binding
BKM78_RS11840	COG0813	purine-nucleoside phosphorylase activity
BKM78_RS11855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BKM78_RS11860	COG2030	dehydratase
BKM78_RS11870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BKM78_RS11875	COG1473	amidohydrolase
BKM78_RS11885	COG1132	(ABC) transporter
BKM78_RS11900	COG0250	Participates in transcription elongation, termination and antitermination
BKM78_RS11905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BKM78_RS11910	COG0081	regulation of translation
BKM78_RS11915	COG1024	Enoyl-CoA hydratase
BKM78_RS11925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BKM78_RS11945	COG0765	amino acid transport
BKM78_RS11955	COG2801	Transposase and inactivated derivatives
BKM78_RS11960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BKM78_RS11965	COG0222	ribosome binding
BKM78_RS11970	COG0085	RNA polymerase activity
BKM78_RS11975	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BKM78_RS11980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BKM78_RS11985	COG0049	tRNA binding
BKM78_RS11990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BKM78_RS11995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BKM78_RS12000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BKM78_RS12010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BKM78_RS12020	COG0435	Glutathione S-transferase
BKM78_RS12030	COG0415	Belongs to the DNA photolyase family
BKM78_RS12060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BKM78_RS12065	COG0051	transcription antitermination factor activity, RNA binding
BKM78_RS12070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BKM78_RS12075	COG0088	Forms part of the polypeptide exit tunnel
BKM78_RS12080	COG0089	rRNA binding
BKM78_RS12085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BKM78_RS12090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BKM78_RS12095	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BKM78_RS12100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BKM78_RS12105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BKM78_RS12110	COG0255	Belongs to the universal ribosomal protein uL29 family
BKM78_RS12115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BKM78_RS12125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BKM78_RS12130	COG0513	Belongs to the DEAD box helicase family
BKM78_RS12135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BKM78_RS12140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BKM78_RS12145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BKM78_RS12150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BKM78_RS12155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BKM78_RS12160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BKM78_RS12165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BKM78_RS12170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BKM78_RS12175	COG1841	ribosomal large subunit assembly
BKM78_RS12180	COG0200	Binds to the 23S rRNA
BKM78_RS12190	COG0563	adenylate kinase activity
BKM78_RS12215	COG0395	ABC-type sugar transport system, permease component
BKM78_RS12220	COG1175	transmembrane transport
BKM78_RS12225	COG1653	transport
BKM78_RS12235	COG1486	melibiose metabolic process
BKM78_RS12245	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BKM78_RS12250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BKM78_RS12255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BKM78_RS12260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BKM78_RS12265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BKM78_RS12270	COG0202	RNA polymerase activity
BKM78_RS12275	COG0203	ribosomal protein L17
BKM78_RS12290	COG4120	Belongs to the binding-protein-dependent transport system permease family
BKM78_RS12295	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BKM78_RS12315	COG0101	tRNA pseudouridine synthase activity
BKM78_RS12320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BKM78_RS12325	COG3304	Inner membrane component domain
BKM78_RS12345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BKM78_RS12350	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BKM78_RS12355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BKM78_RS12365	COG0557	exoribonuclease II activity
BKM78_RS12385	COG1305	Transglutaminase-like
BKM78_RS12415	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BKM78_RS12420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BKM78_RS12425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BKM78_RS12430	COG0604	alcohol dehydrogenase
BKM78_RS12435	COG2409	Drug exporters of the RND superfamily
BKM78_RS12440	COG0174	glutamine synthetase
BKM78_RS12455	COG1823	symporter activity
BKM78_RS12475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BKM78_RS12485	COG0321	lipoyl(octanoyl) transferase activity
BKM78_RS12500	COG0702	epimerase
BKM78_RS12505	COG2226	methyltransferase
BKM78_RS12525	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BKM78_RS12535	COG0508	dehydrogenase complex catalyzes the overall conversion of
BKM78_RS12540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BKM78_RS12550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BKM78_RS12590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BKM78_RS12595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BKM78_RS12620	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BKM78_RS12625	COG0723	plastoquinol--plastocyanin reductase activity
BKM78_RS12635	COG1845	cytochrome c oxidase, subunit III
BKM78_RS12650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BKM78_RS12665	COG3214	Protein conserved in bacteria
BKM78_RS12670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BKM78_RS12680	COG1086	Polysaccharide biosynthesis protein
BKM78_RS12695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BKM78_RS12705	COG1131	(ABC) transporter
BKM78_RS12745	COG2197	response regulator
BKM78_RS12750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BKM78_RS12775	COG0515	serine threonine protein kinase
BKM78_RS12775	COG2815	serine threonine protein kinase
BKM78_RS12780	COG0352	thiamine-phosphate diphosphorylase activity
BKM78_RS12785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BKM78_RS12790	COG0142	geranyltranstransferase activity
BKM78_RS12800	COG3973	AAA domain
BKM78_RS12815	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BKM78_RS12815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BKM78_RS12835	COG0587	DNA-directed DNA polymerase activity
BKM78_RS12840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BKM78_RS12845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BKM78_RS12865	COG0714	Associated with various cellular activities
BKM78_RS12870	COG2001	Belongs to the MraZ family
BKM78_RS12875	COG0275	rRNA processing
BKM78_RS12885	COG0768	penicillin binding
BKM78_RS12895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BKM78_RS12900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BKM78_RS12905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BKM78_RS12910	COG0772	Belongs to the SEDS family
BKM78_RS12915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BKM78_RS12920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BKM78_RS12930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BKM78_RS12935	COG1799	cell septum assembly
BKM78_RS12955	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BKM78_RS12965	COG0469	pyruvate kinase activity
BKM78_RS12980	COG3328	transposase activity
BKM78_RS12990	COG2050	protein possibly involved in aromatic compounds catabolism
BKM78_RS13005	COG0539	negative regulation of cytoplasmic translation
BKM78_RS13010	COG0237	dephospho-CoA kinase activity
BKM78_RS13010	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BKM78_RS13015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BKM78_RS13015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BKM78_RS13020	COG0509	glycine decarboxylation via glycine cleavage system
BKM78_RS13025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BKM78_RS13035	COG0556	nucleotide-excision repair
BKM78_RS13045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BKM78_RS13050	COG0489	protein tyrosine kinase activity
BKM78_RS13070	COG3328	transposase activity
BKM78_RS13085	COG0438	transferase activity, transferring glycosyl groups
BKM78_RS13090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BKM78_RS13095	COG1086	Polysaccharide biosynthesis protein
BKM78_RS13100	COG0322	excinuclease ABC activity
BKM78_RS13105	COG1268	BioY protein
BKM78_RS13110	COG1122	ATPase activity
BKM78_RS13120	COG1660	Displays ATPase and GTPase activities
BKM78_RS13130	COG1481	regulation of sporulation
BKM78_RS13135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BKM78_RS13140	COG0126	phosphoglycerate kinase activity
BKM78_RS13145	COG0149	triose-phosphate isomerase activity
BKM78_RS13150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BKM78_RS13160	COG0363	glucosamine-6-phosphate deaminase activity
BKM78_RS13175	COG0109	protoheme IX farnesyltransferase activity
BKM78_RS13185	COG2814	Major facilitator Superfamily
BKM78_RS13200	COG0339	signal peptide processing
BKM78_RS13235	COG2146	nitrite reductase [NAD(P)H] activity
BKM78_RS13240	COG0396	ATPase activity
BKM78_RS13245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BKM78_RS13275	COG1131	(ABC) transporter
BKM78_RS13290	COG2197	response regulator
BKM78_RS13305	COG0488	(ABC) transporter
BKM78_RS13315	COG0366	Alpha amylase catalytic
BKM78_RS13320	COG2190	(PTS) system
BKM78_RS13320	COG2211	Major facilitator Superfamily
BKM78_RS13325	COG2226	methyltransferase
BKM78_RS13340	COG1028	Short-chain dehydrogenase reductase Sdr
BKM78_RS13345	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BKM78_RS13350	COG1119	ATPase activity
BKM78_RS13375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BKM78_RS13375	COG0512	Glutamine amidotransferase of anthranilate synthase
BKM78_RS13380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BKM78_RS13400	COG0242	peptide deformylase activity
BKM78_RS13405	COG4974	Belongs to the 'phage' integrase family
BKM78_RS13410	COG0739	heme binding
BKM78_RS13415	COG0052	Belongs to the universal ribosomal protein uS2 family
BKM78_RS13420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BKM78_RS13425	COG0528	UMP kinase activity
BKM78_RS13430	COG0233	cytoplasmic translational termination
BKM78_RS13435	COG0575	Belongs to the CDS family
BKM78_RS13440	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BKM78_RS13445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BKM78_RS13455	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BKM78_RS13460	COG0750	zinc metalloprotease
BKM78_RS13465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BKM78_RS13475	COG0442	prolyl-tRNA aminoacylation
BKM78_RS13485	COG0779	Required for maturation of 30S ribosomal subunits
BKM78_RS13490	COG0195	Participates in both transcription termination and antitermination
BKM78_RS13500	COG3583	domain protein
BKM78_RS13515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BKM78_RS13520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BKM78_RS13525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BKM78_RS13530	COG0196	riboflavin kinase activity
BKM78_RS13540	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BKM78_RS13545	COG0506	proline dehydrogenase activity
BKM78_RS13545	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BKM78_RS13545	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BKM78_RS13550	COG1185	polyribonucleotide nucleotidyltransferase activity
BKM78_RS13555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BKM78_RS13570	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BKM78_RS13575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BKM78_RS13580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BKM78_RS13585	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BKM78_RS13590	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BKM78_RS13605	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BKM78_RS13610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BKM78_RS13615	COG0799	negative regulation of ribosome biogenesis
BKM78_RS13620	COG0406	alpha-ribazole phosphatase activity
BKM78_RS13635	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BKM78_RS13640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BKM78_RS13645	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BKM78_RS13650	COG0181	hydroxymethylbilane synthase activity
BKM78_RS13660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BKM78_RS13665	COG0181	hydroxymethylbilane synthase activity
BKM78_RS13680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BKM78_RS13685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BKM78_RS13695	COG0857	belongs to the CobB CobQ family
BKM78_RS13695	COG0280	phosphate acetyltransferase
BKM78_RS13705	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BKM78_RS13730	COG1454	alcohol dehydrogenase
BKM78_RS13730	COG1012	belongs to the aldehyde dehydrogenase family
BKM78_RS13735	COG4816	utilization protein
BKM78_RS13740	COG4302	ethanolamine ammonia-lyase activity
BKM78_RS13755	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
BKM78_RS13775	COG0444	Belongs to the ABC transporter superfamily
BKM78_RS13785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BKM78_RS13790	COG1940	carbohydrate kinase activity
BKM78_RS13795	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BKM78_RS13810	COG0702	epimerase
BKM78_RS13815	COG1017	nitric oxide dioxygenase activity
BKM78_RS13815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BKM78_RS13825	COG1172	Belongs to the binding-protein-dependent transport system permease family
BKM78_RS13835	COG1846	Transcriptional regulator
BKM78_RS13835	COG1940	carbohydrate kinase activity
BKM78_RS13840	COG1129	ABC transporter
BKM78_RS13870	COG3773	Cell wall hydrolase
BKM78_RS13870	COG3409	Peptidoglycan-binding domain 1 protein
BKM78_RS13890	COG1136	(ABC) transporter
BKM78_RS13890	COG0577	efflux transmembrane transporter activity
BKM78_RS13895	COG1136	(ABC) transporter
BKM78_RS13895	COG0577	efflux transmembrane transporter activity
BKM78_RS13910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BKM78_RS13915	COG0495	leucyl-tRNA aminoacylation
BKM78_RS13920	COG1555	photosystem II stabilization
BKM78_RS13920	COG1596	polysaccharide export
BKM78_RS13935	COG0268	Binds directly to 16S ribosomal RNA
BKM78_RS13940	COG0481	GTPase activity
BKM78_RS13945	COG1454	alcohol dehydrogenase
BKM78_RS13965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BKM78_RS13970	COG1420	regulation of RNA biosynthetic process
BKM78_RS13975	COG0484	heat shock protein binding
BKM78_RS13985	COG0343	queuine tRNA-ribosyltransferase activity
BKM78_RS14005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BKM78_RS14020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BKM78_RS14030	COG1175	transmembrane transport
BKM78_RS14035	COG0395	ABC-type sugar transport system, permease component
BKM78_RS14040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BKM78_RS14050	COG1607	acyl-coa hydrolase
BKM78_RS14055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BKM78_RS14060	COG1381	Involved in DNA repair and RecF pathway recombination
BKM78_RS14070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BKM78_RS14075	COG1121	(ABC) transporter
BKM78_RS14080	COG0803	Belongs to the bacterial solute-binding protein 9 family
BKM78_RS14085	COG1653	transport
BKM78_RS14090	COG1175	transmembrane transport
BKM78_RS14095	COG0395	ABC-type sugar transport system, permease component
BKM78_RS14110	COG1846	Transcriptional regulator
BKM78_RS14110	COG1940	carbohydrate kinase activity
BKM78_RS14130	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BKM78_RS14145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BKM78_RS14195	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
BKM78_RS14255	COG0154	amidase activity
BKM78_RS14275	COG0667	Aldo Keto reductase
BKM78_RS14295	COG2814	Major facilitator Superfamily
BKM78_RS14355	COG3328	transposase activity
BKM78_RS14380	COG3547	Transposase (IS116 IS110 IS902 family)
BKM78_RS14460	COG1621	beta-fructofuranosidase activity
BKM78_RS14465	COG1621	beta-fructofuranosidase activity
BKM78_RS14470	COG0395	ABC-type sugar transport system, permease component
BKM78_RS14475	COG1175	transmembrane transport
BKM78_RS14515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BKM78_RS14530	COG0517	IMP dehydrogenase activity
BKM78_RS14530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BKM78_RS14540	COG1172	Belongs to the binding-protein-dependent transport system permease family
BKM78_RS14550	COG1172	Belongs to the binding-protein-dependent transport system permease family
BKM78_RS14565	COG1063	alcohol dehydrogenase
BKM78_RS14575	COG1070	Carbohydrate kinase
BKM78_RS14585	COG2390	Transcriptional regulator
BKM78_RS14595	COG1175	transmembrane transport
BKM78_RS14635	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BKM78_RS14655	COG0714	Associated with various cellular activities
BKM78_RS14665	COG2304	oxidoreductase activity
BKM78_RS14670	COG2304	oxidoreductase activity
BKM78_RS14695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BKM78_RS14700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BKM78_RS14720	COG1115	amino acid carrier protein
BKM78_RS14725	COG1796	DNA polymerase
BKM78_RS14725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BKM78_RS14730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BKM78_RS14740	COG0205	6-phosphofructokinase activity