locus-tag	class	description
C7K43_RS00065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7K43_RS00070	COG4708	membrane
C7K43_RS00080	COG1597	lipid kinase activity
C7K43_RS00090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7K43_RS00100	COG0250	Participates in transcription elongation, termination and antitermination
C7K43_RS00110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C7K43_RS00115	COG0081	regulation of translation
C7K43_RS00120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C7K43_RS00125	COG0222	ribosome binding
C7K43_RS00130	COG2910	NAD(P)H-binding
C7K43_RS00135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_RS00140	COG2723	6-phospho-beta-galactosidase activity
C7K43_RS00145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C7K43_RS00150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C7K43_RS00155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C7K43_RS00160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C7K43_RS00165	COG3870	Protein conserved in bacteria
C7K43_RS00170	COG0470	DNA polymerase III
C7K43_RS00175	COG1774	PSP1 C-terminal conserved region
C7K43_RS00180	COG4467	Involved in initiation control of chromosome replication
C7K43_RS00200	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C7K43_RS00210	COG0732	type I restriction modification DNA specificity domain
C7K43_RS00240	COG0602	queuosine metabolic process
C7K43_RS00250	COG0095	Lipoate-protein ligase
C7K43_RS00255	COG0656	L-ascorbic acid biosynthetic process
C7K43_RS00260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7K43_RS00265	COG4122	O-methyltransferase activity
C7K43_RS00280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7K43_RS00290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C7K43_RS00300	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K43_RS00300	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K43_RS00305	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_RS00305	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS00315	COG3715	PTS system
C7K43_RS00320	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_RS00335	COG4864	UPF0365 protein
C7K43_RS00345	COG0006	proline dipeptidase activity
C7K43_RS00350	COG1302	Protein conserved in bacteria
C7K43_RS00355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7K43_RS00360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C7K43_RS00365	COG1570	exodeoxyribonuclease VII activity
C7K43_RS00370	COG1722	exodeoxyribonuclease VII activity
C7K43_RS00375	COG0142	geranyltranstransferase activity
C7K43_RS00380	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C7K43_RS00385	COG1438	arginine binding
C7K43_RS00390	COG0497	DNA recombination
C7K43_RS00410	COG2001	Belongs to the MraZ family
C7K43_RS00425	COG0768	penicillin binding
C7K43_RS00435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7K43_RS00460	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C7K43_RS00465	COG1799	cell septum assembly
C7K43_RS00470	COG0762	integral membrane protein
C7K43_RS00475	COG2302	S4 RNA-binding domain
C7K43_RS00480	COG3599	regulation of cell shape
C7K43_RS00485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C7K43_RS00490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C7K43_RS00500	COG2309	aminopeptidase activity
C7K43_RS00505	COG1309	transcriptional regulator
C7K43_RS00510	COG0716	FMN binding
C7K43_RS00515	COG0024	Methionine aminopeptidase
C7K43_RS00520	COG1295	ribonuclease BN
C7K43_RS00525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7K43_RS00530	COG3682	Transcriptional regulator
C7K43_RS00535	COG2608	mercury ion transmembrane transporter activity
C7K43_RS00545	COG0436	Aminotransferase
C7K43_RS00550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7K43_RS00555	COG5002	protein histidine kinase activity
C7K43_RS00560	COG0745	RESPONSE REGULATOR receiver
C7K43_RS00565	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C7K43_RS00570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C7K43_RS00580	COG0655	NAD(P)H dehydrogenase (quinone) activity
C7K43_RS00585	COG0228	four-way junction DNA binding
C7K43_RS00590	COG1837	Belongs to the UPF0109 family
C7K43_RS00610	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
C7K43_RS00615	COG3052	prosthetic group binding
C7K43_RS00635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7K43_RS00645	COG2514	catechol 2,3-dioxygenase activity
C7K43_RS00660	COG0336	Belongs to the RNA methyltransferase TrmD family
C7K43_RS00665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C7K43_RS00675	COG3830	Belongs to the UPF0237 family
C7K43_RS00680	COG2848	UPF0210 protein
C7K43_RS00685	COG1956	GAF domain-containing protein
C7K43_RS00700	COG0745	RESPONSE REGULATOR receiver
C7K43_RS00705	COG5002	protein histidine kinase activity
C7K43_RS00705	COG3850	Histidine kinase
C7K43_RS00740	COG1368	sulfuric ester hydrolase activity
C7K43_RS00745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7K43_RS00755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7K43_RS00760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C7K43_RS00765	COG0166	Belongs to the GPI family
C7K43_RS00770	COG0398	Pfam SNARE associated Golgi protein
C7K43_RS00800	COG0561	phosphatase activity
C7K43_RS00805	COG2252	PERMEase
C7K43_RS00815	COG0587	DNA-directed DNA polymerase activity
C7K43_RS00820	COG0205	6-phosphofructokinase activity
C7K43_RS00835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7K43_RS00840	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C7K43_RS00845	COG0745	RESPONSE REGULATOR receiver
C7K43_RS00850	COG5002	protein histidine kinase activity
C7K43_RS00940	COG1396	sequence-specific DNA binding
C7K43_RS00950	COG5632	N-Acetylmuramoyl-L-alanine amidase
C7K43_RS00950	COG5263	repeat protein
C7K43_RS00970	COG3048	D-serine ammonia-lyase activity
C7K43_RS00975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7K43_RS00980	COG1349	DNA-binding transcription factor activity
C7K43_RS00985	COG1882	Formate acetyltransferase
C7K43_RS00990	COG3284	Transcriptional regulator
C7K43_RS00995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7K43_RS01000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C7K43_RS01005	COG0022	dehydrogenase e1 component
C7K43_RS01010	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7K43_RS01025	COG0656	L-ascorbic acid biosynthetic process
C7K43_RS01040	COG4120	Belongs to the binding-protein-dependent transport system permease family
C7K43_RS01050	COG3425	synthase
C7K43_RS01070	COG0741	lytic transglycosylase activity
C7K43_RS01080	COG0358	DNA primase activity
C7K43_RS01085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7K43_RS01105	COG2996	Protein conserved in bacteria
C7K43_RS01110	COG0735	belongs to the Fur family
C7K43_RS01115	COG4974	Belongs to the 'phage' integrase family
C7K43_RS01120	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C7K43_RS01125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C7K43_RS01130	COG1187	pseudouridine synthase activity
C7K43_RS01135	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C7K43_RS01140	COG1141	Ferredoxin
C7K43_RS01150	COG0514	ATP-dependent DNA helicase (RecQ)
C7K43_RS01160	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C7K43_RS01170	COG0539	negative regulation of cytoplasmic translation
C7K43_RS01175	COG1160	GTP binding
C7K43_RS01180	COG0776	regulation of translation
C7K43_RS01190	COG0457	Tetratricopeptide repeat
C7K43_RS01195	COG5582	Belongs to the UPF0302 family
C7K43_RS01205	COG1694	Mazg nucleotide pyrophosphohydrolase
C7K43_RS01210	COG0617	tRNA 3'-terminal CCA addition
C7K43_RS01230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7K43_RS01235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7K43_RS01250	COG1940	carbohydrate kinase activity
C7K43_RS01255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7K43_RS01265	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C7K43_RS01270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7K43_RS01275	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C7K43_RS01280	COG1609	Transcriptional regulator
C7K43_RS01285	COG1214	PFAM Peptidase M22, glycoprotease
C7K43_RS01300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C7K43_RS01305	COG0052	Belongs to the universal ribosomal protein uS2 family
C7K43_RS01310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C7K43_RS01315	COG0528	UMP kinase activity
C7K43_RS01320	COG0233	cytoplasmic translational termination
C7K43_RS01325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C7K43_RS01330	COG4589	Belongs to the CDS family
C7K43_RS01335	COG0750	zinc metalloprotease
C7K43_RS01340	COG0442	prolyl-tRNA aminoacylation
C7K43_RS01350	COG2137	regulation of response to DNA damage stimulus
C7K43_RS01360	COG3557	Belongs to the UPF0374 family
C7K43_RS01370	COG1253	flavin adenine dinucleotide binding
C7K43_RS01375	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C7K43_RS01390	COG0542	response to heat
C7K43_RS01400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_RS01405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7K43_RS01420	COG0438	transferase activity, transferring glycosyl groups
C7K43_RS01425	COG2084	Dehydrogenase
C7K43_RS01430	COG4703	Protein of unknown function (DUF1797)
C7K43_RS01435	COG1428	Deoxynucleoside kinase
C7K43_RS01445	COG1846	Transcriptional regulator
C7K43_RS01450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7K43_RS01455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7K43_RS01460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C7K43_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_RS01475	COG0511	ligase activity, forming carbon-carbon bonds
C7K43_RS01480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7K43_RS01485	COG0439	Biotin carboxylase
C7K43_RS01490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C7K43_RS01495	COG0825	malonyl-CoA metabolic process
C7K43_RS01505	COG1607	acyl-coa hydrolase
C7K43_RS01510	COG4152	abc transporter atp-binding protein
C7K43_RS01515	COG1668	transmembrane transport
C7K43_RS01520	COG0657	acetylesterase activity
C7K43_RS01520	COG2755	lipolytic protein G-D-S-L family
C7K43_RS01525	COG0583	DNA-binding transcription factor activity
C7K43_RS01535	COG1288	antiporter activity
C7K43_RS01540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K43_RS01555	COG1263	PTS System
C7K43_RS01555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS01555	COG2190	(PTS) system
C7K43_RS01560	COG0698	ribose 5-phosphate isomerase
C7K43_RS01565	COG1349	DNA-binding transcription factor activity
C7K43_RS01585	COG3394	polysaccharide catabolic process
C7K43_RS01595	COG2084	Dehydrogenase
C7K43_RS01600	COG3775	system Galactitol-specific IIC component
C7K43_RS01605	COG1609	Transcriptional regulator
C7K43_RS01610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7K43_RS01615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K43_RS01640	COG1373	ATPase (AAA superfamily
C7K43_RS01645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K43_RS01650	COG0765	amino acid transport
C7K43_RS01665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS01665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_RS01670	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_RS01675	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C7K43_RS01680	COG1737	Transcriptional regulator
C7K43_RS01690	COG1263	PTS System
C7K43_RS01690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS01720	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C7K43_RS01745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_RS01745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS01745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS01750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS01755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS01755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_RS01755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS01765	COG1011	Hydrolase
C7K43_RS01785	COG3959	Transketolase, thiamine diphosphate binding domain
C7K43_RS01790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C7K43_RS01800	COG3414	Phosphotransferase system galactitol-specific IIB component
C7K43_RS01805	COG3775	system Galactitol-specific IIC component
C7K43_RS01815	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K43_RS01815	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K43_RS01825	COG4975	Glucose uptake
C7K43_RS01830	COG0673	inositol 2-dehydrogenase activity
C7K43_RS01835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K43_RS01840	COG1063	alcohol dehydrogenase
C7K43_RS01850	COG1105	Belongs to the carbohydrate kinase PfkB family
C7K43_RS01865	COG3684	Belongs to the aldolase LacD family
C7K43_RS01890	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_RS01890	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS01895	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS01905	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_RS01925	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_RS01935	COG1263	PTS System
C7K43_RS01935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS01935	COG2190	(PTS) system
C7K43_RS01940	COG1263	PTS System
C7K43_RS01940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS01955	COG1129	ABC transporter
C7K43_RS01975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_RS01980	COG0277	FAD linked oxidase domain protein
C7K43_RS02000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C7K43_RS02015	COG1175	transmembrane transport
C7K43_RS02020	COG0395	ABC-type sugar transport system, permease component
C7K43_RS02025	COG1621	beta-fructofuranosidase activity
C7K43_RS02045	COG3711	transcriptional antiterminator
C7K43_RS02060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K43_RS02065	COG2188	Transcriptional regulator
C7K43_RS02070	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_RS02080	COG0383	alpha-mannosidase activity
C7K43_RS02100	COG1447	Phosphotransferase system cellobiose-specific component IIA
C7K43_RS02110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_RS02120	COG1621	beta-fructofuranosidase activity
C7K43_RS02125	COG1609	Transcriptional regulator
C7K43_RS02130	COG0366	Alpha amylase catalytic
C7K43_RS02135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS02135	COG1263	PTS System
C7K43_RS02150	COG3715	PTS system
C7K43_RS02155	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_RS02165	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K43_RS02165	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K43_RS02185	COG1082	Xylose isomerase domain protein TIM barrel
C7K43_RS02200	COG1263	PTS System
C7K43_RS02200	COG2190	(PTS) system
C7K43_RS02200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS02205	COG1953	Uracil, thiamine, allantoin
C7K43_RS02210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7K43_RS02215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7K43_RS02230	COG1269	ATP hydrolysis coupled proton transport
C7K43_RS02235	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7K43_RS02245	COG1527	subunit (C
C7K43_RS02250	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
C7K43_RS02255	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C7K43_RS02260	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C7K43_RS02265	COG1394	ATPase activity, coupled to movement of substances
C7K43_RS02275	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C7K43_RS02280	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C7K43_RS02285	COG0471	metal ion transport
C7K43_RS02315	COG0511	ligase activity, forming carbon-carbon bonds
C7K43_RS02320	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C7K43_RS02325	COG1012	belongs to the aldehyde dehydrogenase family
C7K43_RS02345	COG2723	6-phospho-beta-galactosidase activity
C7K43_RS02350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_RS02370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7K43_RS02375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K43_RS02385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS02385	COG1263	PTS System
C7K43_RS02390	COG1486	melibiose metabolic process
C7K43_RS02395	COG1737	Transcriptional regulator
C7K43_RS02430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K43_RS02435	COG0165	Argininosuccinate lyase
C7K43_RS02450	COG2096	Adenosyltransferase
C7K43_RS02475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7K43_RS02495	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C7K43_RS02500	COG1534	Rna-binding protein
C7K43_RS02505	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C7K43_RS02510	COG1713	HD superfamily hydrolase involved in NAD metabolism
C7K43_RS02515	COG0799	negative regulation of ribosome biogenesis
C7K43_RS02520	COG2226	methyltransferase
C7K43_RS02525	COG1323	Belongs to the UPF0348 family
C7K43_RS02530	COG0217	transcriptional regulatory protein
C7K43_RS02535	COG3976	FMN-binding domain protein
C7K43_RS02535	COG1053	succinate dehydrogenase
C7K43_RS02535	COG0431	NADPH-dependent FMN reductase
C7K43_RS02540	COG3976	FMN-binding domain protein
C7K43_RS02540	COG1053	succinate dehydrogenase
C7K43_RS02540	COG0431	NADPH-dependent FMN reductase
C7K43_RS02555	COG3973	AAA domain
C7K43_RS02580	COG1051	belongs to the nudix hydrolase family
C7K43_RS02585	COG3189	MarR family transcriptional regulator
C7K43_RS02605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7K43_RS02610	COG0779	Required for maturation of 30S ribosomal subunits
C7K43_RS02615	COG0195	Participates in both transcription termination and antitermination
C7K43_RS02620	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C7K43_RS02635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C7K43_RS02645	COG0196	riboflavin kinase activity
C7K43_RS02665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7K43_RS02670	COG2814	Major facilitator Superfamily
C7K43_RS02675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7K43_RS02700	COG1126	abc transporter atp-binding protein
C7K43_RS02705	COG0765	amino acid transport
C7K43_RS02710	COG0556	nucleotide-excision repair
C7K43_RS02715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7K43_RS02720	COG1660	Displays ATPase and GTPase activities
C7K43_RS02725	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C7K43_RS02730	COG1481	regulation of sporulation
C7K43_RS02740	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C7K43_RS02750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7K43_RS02770	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C7K43_RS02775	COG1074	ATP-dependent DNA helicase activity
C7K43_RS02780	COG1733	regulation of RNA biosynthetic process
C7K43_RS02785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C7K43_RS02790	COG0072	phenylalanine-tRNA ligase activity
C7K43_RS02790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K43_RS02795	COG0180	Tryptophanyl-tRNA synthetase
C7K43_RS02800	COG1126	abc transporter atp-binding protein
C7K43_RS02805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K43_RS02810	COG0765	amino acid transport
C7K43_RS02815	COG0765	amino acid transport
C7K43_RS02825	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C7K43_RS02830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C7K43_RS02840	COG0517	IMP dehydrogenase activity
C7K43_RS02845	COG0668	transmembrane transport
C7K43_RS02850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C7K43_RS02855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7K43_RS02860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7K43_RS02875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C7K43_RS02885	COG1234	tRNA 3'-trailer cleavage
C7K43_RS02890	COG0300	oxidoreductase activity
C7K43_RS02900	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C7K43_RS02900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C7K43_RS02905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7K43_RS02910	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7K43_RS02920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C7K43_RS02930	COG4224	UPF0291 protein
C7K43_RS02940	COG1388	LysM domain
C7K43_RS02940	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7K43_RS02945	COG0735	belongs to the Fur family
C7K43_RS02950	COG3935	DnaD domain protein
C7K43_RS02955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7K43_RS02960	COG3331	DNA recombination
C7K43_RS02965	COG4474	Belongs to the UPF0398 family
C7K43_RS02970	COG3599	regulation of cell shape
C7K43_RS02980	COG0116	Belongs to the methyltransferase superfamily
C7K43_RS02985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C7K43_RS02995	COG1283	sodium-dependent phosphate transmembrane transporter activity
C7K43_RS03010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K43_RS03030	COG2832	Protein of unknown function (DUF454)
C7K43_RS03040	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_RS03055	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C7K43_RS03060	COG1418	mRNA catabolic process
C7K43_RS03070	COG0513	Belongs to the DEAD box helicase family
C7K43_RS03085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C7K43_RS03095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7K43_RS03100	COG0328	RNA-DNA hybrid ribonuclease activity
C7K43_RS03110	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C7K43_RS03120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C7K43_RS03125	COG0564	pseudouridine synthase activity
C7K43_RS03135	COG2233	PERMEase
C7K43_RS03140	COG0540	Belongs to the ATCase OTCase family
C7K43_RS03145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7K43_RS03150	COG0505	Belongs to the CarA family
C7K43_RS03155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7K43_RS03160	COG0284	orotidine-5'-phosphate decarboxylase activity
C7K43_RS03175	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C7K43_RS03190	COG4120	Belongs to the binding-protein-dependent transport system permease family
C7K43_RS03205	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C7K43_RS03215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7K43_RS03220	COG0287	Prephenate dehydrogenase
C7K43_RS03230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C7K43_RS03235	COG0077	Prephenate dehydratase
C7K43_RS03245	COG1307	EDD domain protein, DegV family
C7K43_RS03250	COG2124	cytochrome p450
C7K43_RS03265	COG0546	phosphoglycolate phosphatase activity
C7K43_RS03270	COG1349	DNA-binding transcription factor activity
C7K43_RS03275	COG4974	Belongs to the 'phage' integrase family
C7K43_RS03310	COG3041	Addiction module toxin RelE StbE family
C7K43_RS03315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7K43_RS03320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7K43_RS03355	COG0456	acetyltransferase
C7K43_RS03360	COG0561	phosphatase activity
C7K43_RS03380	COG1388	LysM domain
C7K43_RS03395	COG0702	epimerase
C7K43_RS03410	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K43_RS03440	COG0167	dihydroorotate dehydrogenase activity
C7K43_RS03445	COG2151	metal-sulfur cluster biosynthetic enzyme
C7K43_RS03455	COG1199	ATP-dependent helicase activity
C7K43_RS03455	COG1199	ATP-dependent helicase activity
C7K43_RS03470	COG1968	undecaprenyl-diphosphatase activity
C7K43_RS03475	COG1392	Phosphate transport regulator
C7K43_RS03480	COG0306	phosphate transporter
C7K43_RS03485	COG0268	Binds directly to 16S ribosomal RNA
C7K43_RS03490	COG1466	dna polymerase III delta subunit
C7K43_RS03495	COG2333	competence protein COMEC
C7K43_RS03495	COG0658	competence protein
C7K43_RS03500	COG2131	deaminase
C7K43_RS03505	COG1555	photosystem II stabilization
C7K43_RS03505	COG1596	polysaccharide export
C7K43_RS03510	COG0546	phosphoglycolate phosphatase activity
C7K43_RS03515	COG0436	Aminotransferase
C7K43_RS03520	COG1126	abc transporter atp-binding protein
C7K43_RS03525	COG0765	amino acid transport
C7K43_RS03530	COG0371	Dehydrogenase
C7K43_RS03535	COG0519	Catalyzes the synthesis of GMP from XMP
C7K43_RS03545	COG0702	epimerase
C7K43_RS03570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7K43_RS03580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7K43_RS03585	COG0154	amidase activity
C7K43_RS03590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7K43_RS03605	COG0038	chloride channel
C7K43_RS03610	COG1349	DNA-binding transcription factor activity
C7K43_RS03615	COG1105	Belongs to the carbohydrate kinase PfkB family
C7K43_RS03620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_RS03620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS03620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS03625	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C7K43_RS03630	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7K43_RS03635	COG0544	peptidyl-prolyl cis-trans isomerase activity
C7K43_RS03645	COG1714	RDD family
C7K43_RS03655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7K43_RS03660	COG1902	pentaerythritol trinitrate reductase activity
C7K43_RS03670	COG2365	Tyrosine phosphatase family
C7K43_RS03685	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C7K43_RS03705	COG0481	GTPase activity
C7K43_RS03715	COG1396	sequence-specific DNA binding
C7K43_RS03720	COG2801	Transposase and inactivated derivatives
C7K43_RS03730	COG0628	permease
C7K43_RS03735	COG0542	response to heat
C7K43_RS03745	COG2195	Cleaves the N-terminal amino acid of tripeptides
C7K43_RS03750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C7K43_RS03755	COG2384	SAM-dependent methyltransferase
C7K43_RS03760	COG1484	DNA-dependent DNA replication
C7K43_RS03770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C7K43_RS03775	COG0237	dephospho-CoA kinase activity
C7K43_RS03780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7K43_RS03785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K43_RS03785	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K43_RS03800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7K43_RS03805	COG3091	SprT-like family
C7K43_RS03810	COG2183	response to ionizing radiation
C7K43_RS03835	COG3480	Lon protease (S16) C-terminal proteolytic domain
C7K43_RS03840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C7K43_RS03845	COG0742	ribosomal rna small subunit methyltransferase
C7K43_RS03850	COG4471	UPF0298 protein
C7K43_RS03865	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C7K43_RS03870	COG0772	Belongs to the SEDS family
C7K43_RS03875	COG4838	Belongs to the UPF0358 family
C7K43_RS03880	COG1217	gtp-binding protein TYPA
C7K43_RS03885	COG0483	inositol monophosphate 1-phosphatase activity
C7K43_RS03890	COG4476	Belongs to the UPF0223 family
C7K43_RS03915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7K43_RS03920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C7K43_RS03925	COG0516	GMP reductase activity
C7K43_RS03930	COG4989	oxidoreductase activity
C7K43_RS03935	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C7K43_RS03940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C7K43_RS03945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7K43_RS03950	COG1966	Carbon starvation protein
C7K43_RS03955	COG3279	Response regulator of the LytR AlgR family
C7K43_RS03960	COG3275	phosphorelay sensor kinase activity
C7K43_RS03970	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7K43_RS03975	COG1876	peptidase activity
C7K43_RS04015	COG0436	Aminotransferase
C7K43_RS04030	COG0667	Aldo Keto reductase
C7K43_RS04035	COG0366	Alpha amylase catalytic
C7K43_RS04035	COG3103	Sh3 type 3 domain protein
C7K43_RS04040	COG0058	SHG alpha-glucan phosphorylase activity
C7K43_RS04050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7K43_RS04055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7K43_RS04065	COG1227	inorganic diphosphatase activity
C7K43_RS04070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7K43_RS04075	COG1882	Formate acetyltransferase
C7K43_RS04080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C7K43_RS04085	COG0187	DNA topoisomerase II activity
C7K43_RS04090	COG1832	CoA-binding protein
C7K43_RS04095	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C7K43_RS04110	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C7K43_RS04115	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C7K43_RS04125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C7K43_RS04130	COG0758	DNA mediated transformation
C7K43_RS04135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7K43_RS04140	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C7K43_RS04150	COG0681	Belongs to the peptidase S26 family
C7K43_RS04155	COG0793	Belongs to the peptidase S41A family
C7K43_RS04160	COG4479	Belongs to the UPF0346 family
C7K43_RS04170	COG4698	Protein conserved in bacteria
C7K43_RS04175	COG2755	lipolytic protein G-D-S-L family
C7K43_RS04180	COG1307	EDD domain protein, DegV family
C7K43_RS04185	COG0371	Dehydrogenase
C7K43_RS04190	COG1272	protein, Hemolysin III
C7K43_RS04200	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C7K43_RS04205	COG0488	(ABC) transporter
C7K43_RS04210	COG0768	penicillin binding
C7K43_RS04215	COG1316	TRANSCRIPTIONal
C7K43_RS04220	COG1682	transport, permease protein
C7K43_RS04225	COG1134	teichoic acid transport
C7K43_RS04230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C7K43_RS04240	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C7K43_RS04245	COG2246	polysaccharide biosynthetic process
C7K43_RS04250	COG2246	polysaccharide biosynthetic process
C7K43_RS04260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7K43_RS04265	COG0463	Glycosyl transferase, family 2
C7K43_RS04270	COG1368	sulfuric ester hydrolase activity
C7K43_RS04285	COG4841	protein insertion into membrane
C7K43_RS04290	COG0569	domain protein
C7K43_RS04295	COG2197	response regulator
C7K43_RS04300	COG4585	Histidine kinase
C7K43_RS04310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7K43_RS04315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C7K43_RS04345	COG0463	Glycosyl transferase, family 2
C7K43_RS04345	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7K43_RS04350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7K43_RS04350	COG0463	Glycosyl transferase, family 2
C7K43_RS04355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7K43_RS04365	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7K43_RS04375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7K43_RS04375	COG0463	Glycosyl transferase, family 2
C7K43_RS04390	COG0017	Asparaginyl-tRNA synthetase
C7K43_RS04395	COG0436	Aminotransferase
C7K43_RS04410	COG1278	Cold shock
C7K43_RS04425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7K43_RS04435	COG0577	efflux transmembrane transporter activity
C7K43_RS04450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7K43_RS04470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7K43_RS04490	COG3588	fructose-bisphosphate aldolase
C7K43_RS04505	COG0523	cobalamin synthesis protein
C7K43_RS04515	COG0492	ferredoxin-NADP+ reductase activity
C7K43_RS04530	COG0596	Alpha beta hydrolase
C7K43_RS04535	COG0604	alcohol dehydrogenase
C7K43_RS04540	COG0745	RESPONSE REGULATOR receiver
C7K43_RS04545	COG5002	protein histidine kinase activity
C7K43_RS04550	COG1136	(ABC) transporter
C7K43_RS04555	COG0577	efflux transmembrane transporter activity
C7K43_RS04580	COG0745	RESPONSE REGULATOR receiver
C7K43_RS04590	COG2205	protein histidine kinase activity
C7K43_RS04595	COG1131	(ABC) transporter
C7K43_RS04645	COG0739	heme binding
C7K43_RS04680	COG1396	sequence-specific DNA binding
C7K43_RS04685	COG2176	DNA-directed DNA polymerase activity
C7K43_RS04715	COG3177	Filamentation induced by cAMP protein fic
C7K43_RS04720	COG0584	glycerophosphoryl diester phosphodiesterase
C7K43_RS04750	COG1447	Phosphotransferase system cellobiose-specific component IIA
C7K43_RS04755	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_RS04760	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K43_RS04760	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K43_RS04770	COG0673	inositol 2-dehydrogenase activity
C7K43_RS04780	COG1686	Belongs to the peptidase S11 family
C7K43_RS04805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7K43_RS04810	COG1254	Belongs to the acylphosphatase family
C7K43_RS04825	COG0751	glycine-tRNA ligase activity
C7K43_RS04830	COG0752	glycyl-tRNA synthetase alpha subunit
C7K43_RS04835	COG1381	Involved in DNA repair and RecF pathway recombination
C7K43_RS04840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C7K43_RS04845	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C7K43_RS04850	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C7K43_RS04860	COG1702	phosphate starvation-inducible protein PhoH
C7K43_RS04865	COG1610	YqeY-like protein
C7K43_RS04870	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C7K43_RS04880	COG1253	flavin adenine dinucleotide binding
C7K43_RS04895	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C7K43_RS04900	COG0083	homoserine kinase activity
C7K43_RS04905	COG0460	homoserine dehydrogenase
C7K43_RS04910	COG0640	Transcriptional regulator
C7K43_RS04915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7K43_RS04920	COG2723	6-phospho-beta-galactosidase activity
C7K43_RS04940	COG3763	UPF0154 protein
C7K43_RS04945	COG0656	L-ascorbic acid biosynthetic process
C7K43_RS04950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C7K43_RS04960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7K43_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_RS04985	COG3775	system Galactitol-specific IIC component
C7K43_RS05000	COG1609	Transcriptional regulator
C7K43_RS05030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C7K43_RS05035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C7K43_RS05040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7K43_RS05045	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C7K43_RS05060	COG1983	PspC domain protein
C7K43_RS05070	COG0704	Plays a role in the regulation of phosphate uptake
C7K43_RS05075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7K43_RS05080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7K43_RS05085	COG0581	inorganic phosphate transmembrane transporter activity
C7K43_RS05090	COG0573	inorganic phosphate transmembrane transporter activity
C7K43_RS05105	COG2177	Part of the ABC transporter FtsEX involved in
C7K43_RS05110	COG2884	Cell division ATP-binding protein ftsE
C7K43_RS05120	COG0653	protein targeting
C7K43_RS05135	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C7K43_RS05140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_RS05150	COG1739	Uncharacterized protein family UPF0029
C7K43_RS05155	COG2188	Transcriptional regulator
C7K43_RS05175	COG0517	IMP dehydrogenase activity
C7K43_RS05180	COG0410	ABC transporter
C7K43_RS05220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7K43_RS05230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C7K43_RS05235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7K43_RS05240	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C7K43_RS05245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C7K43_RS05250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7K43_RS05255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7K43_RS05260	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7K43_RS05265	COG0356	it plays a direct role in the translocation of protons across the membrane
C7K43_RS05270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C7K43_RS05275	COG0557	exoribonuclease II activity
C7K43_RS05285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7K43_RS05295	COG0148	phosphopyruvate hydratase activity
C7K43_RS05300	COG0149	triose-phosphate isomerase activity
C7K43_RS05305	COG0126	phosphoglycerate kinase activity
C7K43_RS05340	COG0095	Lipoate-protein ligase
C7K43_RS05345	COG1078	dGTPase activity
C7K43_RS05355	COG0346	lactoylglutathione lyase activity
C7K43_RS05365	COG3118	belongs to the thioredoxin family
C7K43_RS05370	COG1193	negative regulation of DNA recombination
C7K43_RS05385	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7K43_RS05395	COG2059	Chromate
C7K43_RS05415	COG4175	Glycine betaine
C7K43_RS05415	COG3448	diguanylate cyclase activity
C7K43_RS05420	COG2188	Transcriptional regulator
C7K43_RS05430	COG5646	InterPro IPR014922
C7K43_RS05435	COG1464	Belongs to the NlpA lipoprotein family
C7K43_RS05450	COG3906	Belongs to the UPF0473 family
C7K43_RS05455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C7K43_RS05460	COG4472	Bacterial protein of unknown function (DUF965)
C7K43_RS05465	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C7K43_RS05470	COG0488	(ABC) transporter
C7K43_RS05475	COG0686	Belongs to the AlaDH PNT family
C7K43_RS05490	COG0346	lactoylglutathione lyase activity
C7K43_RS05500	COG1177	transmembrane transport
C7K43_RS05505	COG1176	ABC-type spermidine putrescine transport system, permease component I
C7K43_RS05510	COG3842	ATPase activity
C7K43_RS05515	COG0604	alcohol dehydrogenase
C7K43_RS05525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C7K43_RS05530	COG4684	Psort location CytoplasmicMembrane, score
C7K43_RS05535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C7K43_RS05545	COG2176	DNA-directed DNA polymerase activity
C7K43_RS05550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7K43_RS05555	COG0802	atpase or kinase
C7K43_RS05560	COG0280	phosphate acetyltransferase
C7K43_RS05565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C7K43_RS05570	COG0561	phosphatase activity
C7K43_RS05590	COG0583	DNA-binding transcription factor activity
C7K43_RS05595	COG1368	sulfuric ester hydrolase activity
C7K43_RS05605	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C7K43_RS05630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C7K43_RS05645	COG5002	protein histidine kinase activity
C7K43_RS05650	COG0745	RESPONSE REGULATOR receiver
C7K43_RS05670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C7K43_RS05680	COG2217	Heavy metal translocating P-type atpase
C7K43_RS05695	COG0789	Transcriptional regulator
C7K43_RS05700	COG0656	L-ascorbic acid biosynthetic process
C7K43_RS05760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7K43_RS05775	COG0745	RESPONSE REGULATOR receiver
C7K43_RS05790	COG2205	protein histidine kinase activity
C7K43_RS05820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7K43_RS05825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C7K43_RS05855	COG0367	asparagine synthase
C7K43_RS05865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7K43_RS05870	COG1811	Na channel or pump
C7K43_RS05915	COG0789	Transcriptional regulator
C7K43_RS05920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C7K43_RS05925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7K43_RS05930	COG2130	NADP-dependent
C7K43_RS05960	COG1136	(ABC) transporter
C7K43_RS05985	COG5002	protein histidine kinase activity
C7K43_RS05990	COG0745	RESPONSE REGULATOR receiver
C7K43_RS06040	COG1131	(ABC) transporter
C7K43_RS06045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7K43_RS06050	COG0626	cystathionine gamma-synthase activity
C7K43_RS06060	COG1473	amidohydrolase
C7K43_RS06075	COG3344	reverse transcriptase
C7K43_RS06090	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C7K43_RS06110	COG0604	alcohol dehydrogenase
C7K43_RS06120	COG0640	Transcriptional regulator
C7K43_RS06125	COG0561	phosphatase activity
C7K43_RS06160	COG2261	transglycosylase associated protein
C7K43_RS06210	COG2022	thiamine diphosphate biosynthetic process
C7K43_RS06215	COG2390	Transcriptional regulator
C7K43_RS06225	COG0604	alcohol dehydrogenase
C7K43_RS06225	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_RS06225	COG3321	synthase
C7K43_RS06245	COG0254	rRNA binding
C7K43_RS06255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C7K43_RS06260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7K43_RS06270	COG0504	CTP synthase activity
C7K43_RS06275	COG0174	glutamine synthetase
C7K43_RS06280	COG0789	Transcriptional regulator
C7K43_RS06285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C7K43_RS06290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C7K43_RS06295	COG0584	glycerophosphoryl diester phosphodiesterase
C7K43_RS06305	COG0740	serine-type endopeptidase activity
C7K43_RS06310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C7K43_RS06315	COG1132	(ABC) transporter
C7K43_RS06325	COG5503	Protein of unknown function (DUF1447)
C7K43_RS06340	COG1278	Cold shock
C7K43_RS06345	COG2003	Belongs to the UPF0758 family
C7K43_RS06350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K43_RS06355	COG0285	dihydrofolate synthase activity
C7K43_RS06360	COG0525	valine-tRNA ligase activity
C7K43_RS06365	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C7K43_RS06370	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C7K43_RS06375	COG0301	tRNA thio-modification
C7K43_RS06380	COG1104	cysteine desulfurase activity
C7K43_RS06385	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C7K43_RS06390	COG0527	aspartate kinase activity
C7K43_RS06395	COG4166	transmembrane transport
C7K43_RS06400	COG4876	unkown
C7K43_RS06410	COG0561	phosphatase activity
C7K43_RS06415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C7K43_RS06420	COG0500	methyltransferase
C7K43_RS06425	COG3142	Participates in the control of copper homeostasis
C7K43_RS06430	COG2239	Acts as a magnesium transporter
C7K43_RS06435	COG0564	pseudouridine synthase activity
C7K43_RS06440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C7K43_RS06445	COG2357	RelA SpoT domain protein
C7K43_RS06450	COG4116	CYTH
C7K43_RS06455	COG1164	Oligoendopeptidase f
C7K43_RS06470	COG4862	establishment of competence for transformation
C7K43_RS06475	COG1393	Belongs to the ArsC family
C7K43_RS06480	COG1132	(ABC) transporter
C7K43_RS06485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7K43_RS06490	COG0419	ATPase involved in DNA repair
C7K43_RS06495	COG0420	3'-5' exonuclease activity
C7K43_RS06500	COG0204	Acyl-transferase
C7K43_RS06505	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C7K43_RS06510	COG2827	Endonuclease containing a URI domain
C7K43_RS06515	COG0038	chloride channel
C7K43_RS06525	COG1131	(ABC) transporter
C7K43_RS06535	COG4658	electron transport chain
C7K43_RS06540	COG4656	Part of a membrane complex involved in electron transport
C7K43_RS06545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7K43_RS06565	COG4470	Protein conserved in bacteria
C7K43_RS06570	COG0737	Belongs to the 5'-nucleotidase family
C7K43_RS06585	COG0590	tRNA wobble adenosine to inosine editing
C7K43_RS06595	COG2738	Putative neutral zinc metallopeptidase
C7K43_RS06600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C7K43_RS06605	COG0019	diaminopimelate decarboxylase activity
C7K43_RS06610	COG1473	amidohydrolase
C7K43_RS06615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7K43_RS06620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C7K43_RS06625	COG2171	N-acyltransferase activity
C7K43_RS06650	COG0028	Belongs to the TPP enzyme family
C7K43_RS06660	COG0716	FMN binding
C7K43_RS06670	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C7K43_RS06675	COG0561	phosphatase activity
C7K43_RS06685	COG0719	Fe-S assembly protein
C7K43_RS06690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7K43_RS06705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K43_RS06750	COG0025	NhaP-type Na H and K H
C7K43_RS06755	COG1045	serine acetyltransferase
C7K43_RS06760	COG0626	cystathionine gamma-synthase activity
C7K43_RS06765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7K43_RS06775	COG3527	Alpha-acetolactate decarboxylase
C7K43_RS06780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7K43_RS06805	COG2226	methyltransferase
C7K43_RS06815	COG0517	IMP dehydrogenase activity
C7K43_RS06815	COG1125	glycine betaine transport
C7K43_RS06820	COG1174	glycine betaine transport
C7K43_RS06825	COG1132	(ABC) transporter
C7K43_RS06835	COG3104	oligopeptide transport
C7K43_RS06840	COG1428	Deoxynucleoside kinase
C7K43_RS06850	COG3976	FMN-binding domain protein
C7K43_RS06850	COG1053	succinate dehydrogenase
C7K43_RS06850	COG0431	NADPH-dependent FMN reductase
C7K43_RS06860	COG4221	oxidoreductase activity
C7K43_RS06860	COG3321	synthase
C7K43_RS06860	COG0604	alcohol dehydrogenase
C7K43_RS06860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7K43_RS06865	COG1070	Carbohydrate kinase
C7K43_RS06870	COG2610	gluconate transmembrane transporter activity
C7K43_RS06885	COG0114	fumarate hydratase activity
C7K43_RS06900	COG1653	transport
C7K43_RS06925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7K43_RS06935	COG1132	(ABC) transporter
C7K43_RS06940	COG1132	(ABC) transporter
C7K43_RS06945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C7K43_RS06955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7K43_RS06960	COG0719	Fe-S assembly protein
C7K43_RS06980	COG1185	polyribonucleotide nucleotidyltransferase activity
C7K43_RS06985	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C7K43_RS06995	COG0628	permease
C7K43_RS07005	COG2706	6-phosphogluconolactonase activity
C7K43_RS07010	COG0488	(ABC) transporter
C7K43_RS07035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K43_RS07035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K43_RS07045	COG2239	Acts as a magnesium transporter
C7K43_RS07070	COG0675	Transposase, IS605 OrfB family
C7K43_RS07075	COG4608	Belongs to the ABC transporter superfamily
C7K43_RS07080	COG0444	Belongs to the ABC transporter superfamily
C7K43_RS07085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7K43_RS07090	COG0601	transmembrane transport
C7K43_RS07100	COG4166	transmembrane transport
C7K43_RS07105	COG4166	transmembrane transport
C7K43_RS07110	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7K43_RS07115	COG1674	ftsk spoiiie
C7K43_RS07115	COG1280	lysine exporter protein (LysE YggA)
C7K43_RS07120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K43_RS07125	COG1126	abc transporter atp-binding protein
C7K43_RS07130	COG0765	amino acid transport
C7K43_RS07135	COG2508	Transcriptional regulator
C7K43_RS07140	COG3842	ATPase activity
C7K43_RS07155	COG0482	sulfurtransferase activity
C7K43_RS07165	COG1104	cysteine desulfurase activity
C7K43_RS07170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7K43_RS07180	COG3590	peptidase
C7K43_RS07185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7K43_RS07205	COG3853	Toxic anion resistance protein (TelA)
C7K43_RS07210	COG0531	amino acid
C7K43_RS07215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7K43_RS07220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7K43_RS07235	COG2801	Transposase and inactivated derivatives
C7K43_RS07245	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C7K43_RS07250	COG1490	D-aminoacyl-tRNA deacylase activity
C7K43_RS07255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7K43_RS07260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C7K43_RS07265	COG2264	protein methyltransferase activity
C7K43_RS07275	COG2094	Belongs to the DNA glycosylase MPG family
C7K43_RS07280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7K43_RS07310	COG0589	response to stress
C7K43_RS07320	COG1131	(ABC) transporter
C7K43_RS07325	COG1309	transcriptional regulator
C7K43_RS07340	COG0561	phosphatase activity
C7K43_RS07345	COG0656	L-ascorbic acid biosynthetic process
C7K43_RS07355	COG0656	L-ascorbic acid biosynthetic process
C7K43_RS07360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C7K43_RS07370	COG4473	ABC transporter
C7K43_RS07375	COG1131	(ABC) transporter
C7K43_RS07380	COG1132	(ABC) transporter
C7K43_RS07395	COG0242	peptide deformylase activity
C7K43_RS07405	COG1464	Belongs to the NlpA lipoprotein family
C7K43_RS07410	COG2011	ABC-type metal ion transport system permease component
C7K43_RS07415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7K43_RS07420	COG1827	regulation of RNA biosynthetic process
C7K43_RS07425	COG0110	maltose O-acetyltransferase activity
C7K43_RS07435	COG0765	amino acid transport
C7K43_RS07440	COG1126	abc transporter atp-binding protein
C7K43_RS07445	COG1114	Component of the transport system for branched-chain amino acids
C7K43_RS07455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7K43_RS07460	COG2255	four-way junction helicase activity
C7K43_RS07465	COG0632	four-way junction helicase activity
C7K43_RS07495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C7K43_RS07500	COG4550	Control of competence regulator ComK, YlbF/YmcA
C7K43_RS07505	COG1692	metallophosphoesterase
C7K43_RS07510	COG0561	phosphatase activity
C7K43_RS07515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7K43_RS07525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C7K43_RS07540	COG3279	Response regulator of the LytR AlgR family
C7K43_RS07550	COG1268	BioY protein
C7K43_RS07555	COG4493	Belongs to the UPF0637 family
C7K43_RS07580	COG2918	glutathione biosynthetic process
C7K43_RS07580	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7K43_RS07585	COG2723	6-phospho-beta-galactosidase activity
C7K43_RS07590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS07590	COG1263	PTS System
C7K43_RS07590	COG2190	(PTS) system
C7K43_RS07595	COG2188	Transcriptional regulator
C7K43_RS07600	COG0552	protein localization to endoplasmic reticulum
C7K43_RS07605	COG0561	phosphatase activity
C7K43_RS07610	COG1196	nuclear chromosome segregation
C7K43_RS07615	COG0571	ribonuclease III activity
C7K43_RS07630	COG0601	transmembrane transport
C7K43_RS07635	COG4608	Belongs to the ABC transporter superfamily
C7K43_RS07645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7K43_RS07650	COG0416	fatty acid biosynthetic process
C7K43_RS07655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7K43_RS07680	COG1461	Dihydroxyacetone kinase
C7K43_RS07690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7K43_RS07700	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C7K43_RS07740	COG0174	glutamine synthetase
C7K43_RS07755	COG1122	ATPase activity
C7K43_RS07760	COG1122	ATPase activity
C7K43_RS07765	COG0203	ribosomal protein L17
C7K43_RS07770	COG0202	RNA polymerase activity
C7K43_RS07775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C7K43_RS07780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C7K43_RS07785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7K43_RS07790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C7K43_RS07795	COG0563	adenylate kinase activity
C7K43_RS07805	COG0200	Binds to the 23S rRNA
C7K43_RS07810	COG1841	ribosomal large subunit assembly
C7K43_RS07815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C7K43_RS07820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C7K43_RS07825	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C7K43_RS07830	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C7K43_RS07835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7K43_RS07840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C7K43_RS07845	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C7K43_RS07850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C7K43_RS07855	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C7K43_RS07860	COG0255	Belongs to the universal ribosomal protein uL29 family
C7K43_RS07865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C7K43_RS07870	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C7K43_RS07875	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C7K43_RS07880	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C7K43_RS07885	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C7K43_RS07890	COG0089	rRNA binding
C7K43_RS07895	COG0088	Forms part of the polypeptide exit tunnel
C7K43_RS07900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C7K43_RS07925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7K43_RS07930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_RS07940	COG1447	Phosphotransferase system cellobiose-specific component IIA
C7K43_RS07945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_RS07945	COG3711	transcriptional antiterminator
C7K43_RS07950	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_RS07965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7K43_RS07970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7K43_RS07975	COG0049	tRNA binding
C7K43_RS07980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C7K43_RS07985	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C7K43_RS07990	COG0588	phosphoglycerate mutase activity
C7K43_RS07995	COG1979	alcohol dehydrogenase
C7K43_RS08005	COG0813	purine-nucleoside phosphorylase activity
C7K43_RS08010	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C7K43_RS08015	COG1079	Belongs to the binding-protein-dependent transport system permease family
C7K43_RS08020	COG4603	Belongs to the binding-protein-dependent transport system permease family
C7K43_RS08025	COG3845	ABC transporter
C7K43_RS08030	COG1744	ABC transporter substrate-binding protein PnrA-like
C7K43_RS08035	COG0295	cytidine deaminase activity
C7K43_RS08040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K43_RS08045	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C7K43_RS08050	COG1609	Transcriptional regulator
C7K43_RS08055	COG2813	Specifically methylates the guanine in position
C7K43_RS08060	COG1072	(Pantothenic acid kinase))
C7K43_RS08065	COG0519	Catalyzes the synthesis of GMP from XMP
C7K43_RS08065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C7K43_RS08070	COG0456	acetyltransferase
C7K43_RS08075	COG0456	acetyltransferase
C7K43_RS08075	COG1846	Transcriptional regulator
C7K43_RS08085	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C7K43_RS08100	COG1114	Component of the transport system for branched-chain amino acids
C7K43_RS08110	COG1396	sequence-specific DNA binding
C7K43_RS08130	COG0024	Methionine aminopeptidase
C7K43_RS08140	COG0708	Exodeoxyribonuclease III
C7K43_RS08145	COG0628	permease
C7K43_RS08165	COG1131	(ABC) transporter
C7K43_RS08190	COG0693	protein deglycase activity
C7K43_RS08195	COG0625	glutathione transferase activity
C7K43_RS08210	COG1694	Mazg nucleotide pyrophosphohydrolase
C7K43_RS08215	COG0789	Transcriptional regulator
C7K43_RS08230	COG2378	regulation of single-species biofilm formation
C7K43_RS08240	COG1464	Belongs to the NlpA lipoprotein family
C7K43_RS08245	COG1286	toxin biosynthetic process
C7K43_RS08265	COG1388	LysM domain
C7K43_RS08280	COG1131	(ABC) transporter
C7K43_RS08300	COG0471	metal ion transport
C7K43_RS08305	COG2197	response regulator
C7K43_RS08310	COG4585	Histidine kinase
C7K43_RS08315	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C7K43_RS08320	COG0259	pyridoxamine-phosphate oxidase activity
C7K43_RS08325	COG1388	LysM domain
C7K43_RS08340	COG1263	PTS System
C7K43_RS08340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS08340	COG2190	(PTS) system
C7K43_RS08355	COG2340	Cysteine-rich secretory protein family
C7K43_RS08365	COG1305	Transglutaminase-like
C7K43_RS08375	COG0714	Associated with various cellular activities
C7K43_RS08385	COG0435	Glutathione S-transferase
C7K43_RS08390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C7K43_RS08395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7K43_RS08400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C7K43_RS08415	COG2190	(PTS) system
C7K43_RS08415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS08415	COG1263	PTS System
C7K43_RS08420	COG3711	transcriptional antiterminator
C7K43_RS08440	COG1309	transcriptional regulator
C7K43_RS08465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7K43_RS08465	COG0574	Belongs to the PEP-utilizing enzyme family
C7K43_RS08470	COG0517	IMP dehydrogenase activity
C7K43_RS08475	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C7K43_RS08480	COG0039	L-malate dehydrogenase activity
C7K43_RS08485	COG0726	polysaccharide deacetylase
C7K43_RS08485	COG1649	PFAM Uncharacterised BCR, COG1649
C7K43_RS08490	COG1737	Transcriptional regulator
C7K43_RS08495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7K43_RS08505	COG1263	PTS System
C7K43_RS08505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS08510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C7K43_RS08525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C7K43_RS08675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C7K43_RS08680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C7K43_RS08690	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C7K43_RS08695	COG0037	tRNA processing
C7K43_RS08700	COG1098	S1 RNA binding domain
C7K43_RS08710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C7K43_RS08715	COG2244	polysaccharide biosynthetic process
C7K43_RS08720	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C7K43_RS08725	COG0193	aminoacyl-tRNA hydrolase activity
C7K43_RS08730	COG0039	L-malate dehydrogenase activity
C7K43_RS08740	COG0217	transcriptional regulatory protein
C7K43_RS08755	COG2814	Major facilitator Superfamily
C7K43_RS08760	COG1012	belongs to the aldehyde dehydrogenase family
C7K43_RS08770	COG2814	Major facilitator Superfamily
C7K43_RS08780	COG1252	NADH dehydrogenase
C7K43_RS08800	COG4166	transmembrane transport
C7K43_RS08810	COG0803	Belongs to the bacterial solute-binding protein 9 family
C7K43_RS08810	COG3443	Belongs to the bacterial solute-binding protein 9 family
C7K43_RS08820	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C7K43_RS08825	COG4988	ABC transporter
C7K43_RS08830	COG1294	oxidase, subunit
C7K43_RS08835	COG1271	oxidase subunit
C7K43_RS08850	COG4975	Glucose uptake
C7K43_RS08855	COG0018	arginyl-trna synthetase
C7K43_RS08865	COG1846	Transcriptional regulator
C7K43_RS08885	COG2153	protein acetylation
C7K43_RS08915	COG1288	antiporter activity
C7K43_RS08925	COG0549	Belongs to the carbamate kinase family
C7K43_RS08935	COG1438	arginine binding
C7K43_RS08950	COG1438	arginine binding
C7K43_RS08955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_RS08955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_RS08960	COG2723	6-phospho-beta-galactosidase activity
C7K43_RS08965	COG1447	Phosphotransferase system cellobiose-specific component IIA
C7K43_RS08970	COG3684	Belongs to the aldolase LacD family
C7K43_RS08980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K43_RS09010	COG1349	DNA-binding transcription factor activity
C7K43_RS09040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C7K43_RS09045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C7K43_RS09055	COG1940	carbohydrate kinase activity
C7K43_RS09065	COG1744	ABC transporter substrate-binding protein PnrA-like
C7K43_RS09080	COG1054	Belongs to the UPF0176 family
C7K43_RS09090	COG1394	ATPase activity, coupled to movement of substances
C7K43_RS09095	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C7K43_RS09100	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C7K43_RS09110	COG1527	subunit (C
C7K43_RS09115	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
C7K43_RS09120	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7K43_RS09125	COG1269	ATP hydrolysis coupled proton transport
C7K43_RS09140	COG1285	pathogenesis
C7K43_RS09145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7K43_RS09155	COG2217	Heavy metal translocating P-type atpase
C7K43_RS09165	COG0702	epimerase
C7K43_RS09180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7K43_RS09185	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_RS09190	COG3715	PTS system
C7K43_RS09205	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K43_RS09205	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K43_RS09215	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K43_RS09215	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K43_RS09265	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_RS09270	COG3715	PTS system
C7K43_RS09275	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS09285	COG3684	Belongs to the aldolase LacD family
C7K43_RS09290	COG2222	sugar isomerase
C7K43_RS09295	COG2188	Transcriptional regulator
C7K43_RS09300	COG1461	Dihydroxyacetone kinase
C7K43_RS09305	COG2376	Dihydroxyacetone kinase
C7K43_RS09310	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C7K43_RS09315	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K43_RS09320	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C7K43_RS09330	COG3118	belongs to the thioredoxin family
C7K43_RS09335	COG0386	Belongs to the glutathione peroxidase family
C7K43_RS09340	COG1846	Transcriptional regulator
C7K43_RS09345	COG0492	ferredoxin-NADP+ reductase activity
C7K43_RS09355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C7K43_RS09370	COG0322	excinuclease ABC activity
C7K43_RS09385	COG1233	COG1233 Phytoene dehydrogenase and related
C7K43_RS09390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7K43_RS09400	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C7K43_RS09405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7K43_RS09410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K43_RS09415	COG0589	response to stress
C7K43_RS09420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7K43_RS09425	COG1363	Peptidase, m42
C7K43_RS09445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C7K43_RS09455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C7K43_RS09460	COG0827	DNA restriction-modification system
C7K43_RS09485	COG4537	Required for transformation and DNA binding
C7K43_RS09490	COG1459	type II secretion system
C7K43_RS09495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7K43_RS09500	COG2755	lipolytic protein G-D-S-L family
C7K43_RS09500	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C7K43_RS09505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C7K43_RS09510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C7K43_RS09515	COG0124	histidyl-tRNA synthetase
C7K43_RS09520	COG0824	Thioesterase
C7K43_RS09540	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C7K43_RS09545	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C7K43_RS09550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C7K43_RS09555	COG4166	transmembrane transport
C7K43_RS09560	COG2508	Transcriptional regulator
C7K43_RS09565	COG0402	S-adenosylhomocysteine deaminase activity
C7K43_RS09570	COG0402	S-adenosylhomocysteine deaminase activity
C7K43_RS09575	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K43_RS09580	COG1428	Deoxynucleoside kinase
C7K43_RS09585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C7K43_RS09600	COG1304	FMN binding
C7K43_RS09610	COG0343	queuine tRNA-ribosyltransferase activity
C7K43_RS09625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C7K43_RS09650	COG0531	amino acid
C7K43_RS09655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C7K43_RS09665	COG2337	Toxic component of a toxin-antitoxin (TA) module
C7K43_RS09675	COG0736	holo-[acyl-carrier-protein] synthase activity
C7K43_RS09685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7K43_RS09690	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7K43_RS09695	COG1671	Belongs to the UPF0178 family
C7K43_RS09725	COG0572	uridine kinase
C7K43_RS09730	COG1011	Hydrolase
C7K43_RS09735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C7K43_RS09740	COG0509	glycine decarboxylation via glycine cleavage system
C7K43_RS09745	COG1393	Belongs to the ArsC family
C7K43_RS09750	COG0772	Belongs to the SEDS family
C7K43_RS09770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C7K43_RS09775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C7K43_RS09780	COG0009	L-threonylcarbamoyladenylate synthase
C7K43_RS09785	COG2890	protein-(glutamine-N5) methyltransferase activity
C7K43_RS09790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C7K43_RS09795	COG1435	thymidine kinase activity
C7K43_RS09815	COG0071	Belongs to the small heat shock protein (HSP20) family
C7K43_RS09820	COG0514	ATP-dependent DNA helicase (RecQ)
C7K43_RS09830	COG0681	Belongs to the peptidase S26 family
C7K43_RS09835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7K43_RS09840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7K43_RS09845	COG3442	glutamine amidotransferase
C7K43_RS09850	COG1263	PTS System
C7K43_RS09850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS09850	COG2190	(PTS) system
C7K43_RS09860	COG1482	cell wall glycoprotein biosynthetic process
C7K43_RS09875	COG0537	adenosine 5'-monophosphoramidase activity
C7K43_RS09885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7K43_RS09890	COG3481	metal-dependent phosphohydrolase, HD sub domain
C7K43_RS09915	COG3679	Belongs to the UPF0342 family
C7K43_RS09920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7K43_RS09925	COG0564	pseudouridine synthase activity
C7K43_RS09930	COG1187	pseudouridine synthase activity
C7K43_RS09935	COG2244	polysaccharide biosynthetic process
C7K43_RS09940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C7K43_RS09950	COG1764	response to oxidative stress
C7K43_RS09955	COG1929	Belongs to the glycerate kinase type-1 family
C7K43_RS09960	COG0495	leucyl-tRNA aminoacylation
C7K43_RS09965	COG1388	LysM domain
C7K43_RS09965	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7K43_RS09970	COG0671	phosphoesterase, PA-phosphatase related
C7K43_RS09975	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C7K43_RS09995	COG3775	system Galactitol-specific IIC component
C7K43_RS10000	COG3414	Phosphotransferase system galactitol-specific IIB component
C7K43_RS10005	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C7K43_RS10010	COG0693	protein deglycase activity
C7K43_RS10020	COG0488	(ABC) transporter
C7K43_RS10025	COG1464	Belongs to the NlpA lipoprotein family
C7K43_RS10030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7K43_RS10045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K43_RS10050	COG1609	Transcriptional regulator
C7K43_RS10065	COG2723	6-phospho-beta-galactosidase activity
C7K43_RS10070	COG1940	carbohydrate kinase activity
C7K43_RS10075	COG2205	protein histidine kinase activity
C7K43_RS10090	COG0745	RESPONSE REGULATOR receiver
C7K43_RS10095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C7K43_RS10105	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C7K43_RS10105	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C7K43_RS10120	COG4939	FMN-binding domain protein
C7K43_RS10135	COG0142	geranyltranstransferase activity
C7K43_RS10140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7K43_RS10145	COG0456	acetyltransferase
C7K43_RS10150	COG0826	peptidase U32
C7K43_RS10155	COG0826	peptidase U32
C7K43_RS10160	COG1011	Hydrolase
C7K43_RS10165	COG0542	response to heat
C7K43_RS10170	COG4463	regulation of RNA biosynthetic process
C7K43_RS10175	COG2815	serine threonine protein kinase
C7K43_RS10175	COG0515	serine threonine protein kinase
C7K43_RS10185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7K43_RS10185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7K43_RS10190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7K43_RS10195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C7K43_RS10200	COG1758	RNA polymerase activity
C7K43_RS10205	COG0194	GDP metabolic process
C7K43_RS10210	COG4443	Transcriptional Coactivator p15 (PC4)
C7K43_RS10225	COG0351	phosphomethylpyrimidine kinase
C7K43_RS10255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7K43_RS10260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C7K43_RS10265	COG0105	UTP biosynthetic process
C7K43_RS10270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7K43_RS10275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7K43_RS10280	COG1121	(ABC) transporter
C7K43_RS10285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C7K43_RS10290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS10290	COG1263	PTS System
C7K43_RS10295	COG1554	hydrolase, family 65, central catalytic
C7K43_RS10300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K43_RS10305	COG2188	Transcriptional regulator
C7K43_RS10310	COG1418	mRNA catabolic process
C7K43_RS10320	COG1546	Belongs to the CinA family
C7K43_RS10320	COG1058	Belongs to the CinA family
C7K43_RS10325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C7K43_RS10330	COG1426	Protein conserved in bacteria
C7K43_RS10335	COG0612	Peptidase, M16
C7K43_RS10340	COG0612	Peptidase, M16
C7K43_RS10345	COG1970	mechanosensitive ion channel activity
C7K43_RS10350	COG4466	Protein conserved in bacteria
C7K43_RS10360	COG3688	RNA-binding protein containing a PIN domain
C7K43_RS10365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7K43_RS10370	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C7K43_RS10375	COG0215	cysteine-tRNA ligase activity
C7K43_RS10380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7K43_RS10385	COG4956	integral membrane protein (PIN domain superfamily)
C7K43_RS10395	COG0756	dUTP diphosphatase activity
C7K43_RS10400	COG0656	L-ascorbic acid biosynthetic process
C7K43_RS10405	COG3949	Membrane
C7K43_RS10415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C7K43_RS10420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C7K43_RS10435	COG0488	(ABC) transporter
C7K43_RS10445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C7K43_RS10450	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C7K43_RS10455	COG0305	Participates in initiation and elongation during chromosome replication
C7K43_RS10460	COG0359	binds to the 23S rRNA
C7K43_RS10470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7K43_RS10475	COG0629	single-stranded DNA binding
C7K43_RS10480	COG0360	Binds together with S18 to 16S ribosomal RNA
C7K43_RS10485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C7K43_RS10490	COG0187	DNA topoisomerase II activity
C7K43_RS10495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7K43_RS10500	COG2501	S4 domain
C7K43_RS10505	COG0592	DNA-directed DNA polymerase activity
C7K43_RS10510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7K43_RS10520	COG0594	ribonuclease P activity
C7K43_RS10525	COG0706	membrane insertase activity
C7K43_RS10540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C7K43_RS10545	COG0445	tRNA wobble uridine modification
C7K43_RS10560	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_RS10565	COG2271	Major facilitator Superfamily
C7K43_RS10575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C7K43_RS10600	COG1380	Effector of murein hydrolase LrgA
C7K43_RS10605	COG1346	cytolysis
C7K43_RS10610	COG1304	FMN binding
C7K43_RS10630	COG1442	glycosyl transferase family 8
C7K43_RS10635	COG0357	Ribosomal RNA small subunit methyltransferase G
C7K43_RS10640	COG1192	Involved in chromosome partitioning
C7K43_RS10645	COG1475	DNA binding
C7K43_RS10650	COG4481	Protein conserved in bacteria
C7K43_RS10655	COG0012	GTP binding
C7K43_RS10665	COG0517	IMP dehydrogenase activity
C7K43_RS10665	COG0516	GMP reductase activity
C7K43_RS10670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7K43_RS10745	COG1162	GTPase activity
C7K43_RS10750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K43_RS10760	COG1792	Involved in formation and maintenance of cell shape
C7K43_RS10780	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C7K43_RS10785	COG0783	Belongs to the Dps family
C7K43_RS10800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7K43_RS10810	COG0488	(ABC) transporter
C7K43_RS10815	COG0577	efflux transmembrane transporter activity
C7K43_RS10815	COG1136	(ABC) transporter
C7K43_RS10820	COG0366	Alpha amylase catalytic
C7K43_RS10825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7K43_RS10830	COG0335	large ribosomal subunit rRNA binding
C7K43_RS10835	COG0789	Transcriptional regulator
C7K43_RS10840	COG0183	Belongs to the thiolase family
C7K43_RS10845	COG0300	oxidoreductase activity
C7K43_RS10850	COG4584	PFAM Integrase catalytic
C7K43_RS10850	COG2390	Transcriptional regulator
C7K43_RS10855	COG1484	DNA-dependent DNA replication
C7K43_RS10860	COG3655	Transcriptional regulator
C7K43_RS10895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7K43_RS10905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7K43_RS10910	COG0471	metal ion transport
C7K43_RS10920	COG2213	PTS system mannitol-specific
C7K43_RS10925	COG3711	transcriptional antiterminator
C7K43_RS10930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_RS10935	COG0246	Mannitol dehydrogenase
C7K43_RS10940	COG0363	glucosamine-6-phosphate deaminase activity
C7K43_RS10945	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C7K43_RS10950	COG4109	DRTGG domain
C7K43_RS10955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C7K43_RS10970	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_RS10975	COG3001	Fructosamine kinase
C7K43_RS10985	COG0531	amino acid
C7K43_RS10990	COG1082	Xylose isomerase domain protein TIM barrel
C7K43_RS10990	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C7K43_RS10995	COG1053	succinate dehydrogenase
C7K43_RS11020	COG1408	metallophosphoesterase
C7K43_RS11030	COG0084	hydrolase, TatD family'
C7K43_RS11035	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C7K43_RS11040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C7K43_RS11050	COG0738	Major facilitator superfamily
C7K43_RS11055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7K43_RS11095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7K43_RS11100	COG1121	(ABC) transporter
C7K43_RS11105	COG1914	H( )-stimulated, divalent metal cation uptake system
C7K43_RS11140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C7K43_RS11145	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C7K43_RS11150	COG1472	Belongs to the glycosyl hydrolase 3 family
C7K43_RS11175	COG3448	diguanylate cyclase activity
C7K43_RS11175	COG4175	Glycine betaine
C7K43_RS11190	COG5039	Polysaccharide pyruvyl transferase
C7K43_RS11200	COG2261	transglycosylase associated protein
C7K43_RS11215	COG1132	(ABC) transporter
C7K43_RS11220	COG1132	(ABC) transporter
C7K43_RS11225	COG2249	NAD(P)H dehydrogenase (quinone) activity
C7K43_RS11245	COG3711	transcriptional antiterminator
C7K43_RS11250	COG1263	PTS System
C7K43_RS11250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS11250	COG2190	(PTS) system
C7K43_RS11260	COG0741	lytic transglycosylase activity
C7K43_RS11260	COG0739	heme binding
C7K43_RS11260	COG1196	nuclear chromosome segregation
C7K43_RS11265	COG0628	permease
C7K43_RS11270	COG1388	LysM domain
C7K43_RS11270	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7K43_RS11290	COG1316	TRANSCRIPTIONal
C7K43_RS11295	COG3944	biosynthesis protein
C7K43_RS11300	COG0489	protein tyrosine kinase activity
C7K43_RS11305	COG4464	protein tyrosine phosphatase activity
C7K43_RS11315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7K43_RS11325	COG0438	transferase activity, transferring glycosyl groups
C7K43_RS11340	COG0463	Glycosyl transferase, family 2
C7K43_RS11410	COG0210	DNA helicase
C7K43_RS11435	COG1484	DNA-dependent DNA replication
C7K43_RS11440	COG1263	PTS System
C7K43_RS11440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS11440	COG2190	(PTS) system
C7K43_RS11445	COG2002	toxin-antitoxin pair type II binding
C7K43_RS11515	COG2050	protein possibly involved in aromatic compounds catabolism
C7K43_RS11520	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C7K43_RS11525	COG0318	PFAM AMP-dependent synthetase and ligase
C7K43_RS11560	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K43_RS11565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS11565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_RS11565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS11570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS11575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS11575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS11585	COG3620	sequence-specific DNA binding
C7K43_RS11635	COG1609	Transcriptional regulator
C7K43_RS11640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7K43_RS11645	COG1869	D-ribose catabolic process
C7K43_RS11650	COG1129	ABC transporter
C7K43_RS11655	COG1172	Belongs to the binding-protein-dependent transport system permease family
C7K43_RS11660	COG1879	ABC-type sugar transport system periplasmic component
C7K43_RS11665	COG1846	Transcriptional regulator
C7K43_RS11665	COG1940	carbohydrate kinase activity
C7K43_RS11675	COG1070	Carbohydrate kinase
C7K43_RS11690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS11695	COG3715	PTS system
C7K43_RS11700	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_RS11730	COG2814	Major facilitator Superfamily
C7K43_RS11750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7K43_RS11755	COG1373	ATPase (AAA superfamily
C7K43_RS11785	COG1518	maintenance of DNA repeat elements
C7K43_RS11790	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C7K43_RS11800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7K43_RS11805	COG3835	regulator
C7K43_RS11810	COG1953	Uracil, thiamine, allantoin
C7K43_RS11825	COG0668	transmembrane transport
C7K43_RS11835	COG0095	Lipoate-protein ligase
C7K43_RS11840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7K43_RS11845	COG2011	ABC-type metal ion transport system permease component
C7K43_RS11855	COG0583	DNA-binding transcription factor activity
C7K43_RS11865	COG2059	Chromate
C7K43_RS11890	COG0191	fructose-bisphosphate aldolase activity
C7K43_RS11905	COG3715	PTS system
C7K43_RS11910	COG3716	PTS system mannose fructose sorbose family IID component
C7K43_RS11915	COG1349	DNA-binding transcription factor activity
C7K43_RS11930	COG1914	H( )-stimulated, divalent metal cation uptake system
C7K43_RS11940	COG2337	Toxic component of a toxin-antitoxin (TA) module
C7K43_RS11950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_RS11950	COG3711	transcriptional antiterminator
C7K43_RS11960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS11965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS11965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_RS11965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K43_RS11970	COG0383	alpha-mannosidase activity
C7K43_RS12015	COG2190	(PTS) system
C7K43_RS12015	COG1263	PTS System
C7K43_RS12015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS12025	COG3711	transcriptional antiterminator
C7K43_RS12075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K43_RS12080	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C7K43_RS12085	COG2390	Transcriptional regulator
C7K43_RS12100	COG2755	lipolytic protein G-D-S-L family
C7K43_RS12100	COG0657	acetylesterase activity
C7K43_RS12115	COG0561	phosphatase activity
C7K43_RS12120	COG4297	protein containing double-stranded beta helix domain
C7K43_RS12130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C7K43_RS12150	COG1012	belongs to the aldehyde dehydrogenase family
C7K43_RS12150	COG1454	alcohol dehydrogenase
C7K43_RS12160	COG4166	transmembrane transport
C7K43_RS12165	COG2195	Cleaves the N-terminal amino acid of tripeptides
C7K43_RS12175	COG1737	Transcriptional regulator
C7K43_RS12180	COG1486	melibiose metabolic process
C7K43_RS12185	COG1263	PTS System
C7K43_RS12185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K43_RS12190	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C7K43_RS12200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K43_RS12220	COG0191	fructose-bisphosphate aldolase activity
C7K43_RS12230	COG3711	transcriptional antiterminator
C7K43_RS12240	COG3414	Phosphotransferase system galactitol-specific IIB component
C7K43_RS12245	COG3775	system Galactitol-specific IIC component
C7K43_RS12255	COG0235	Class ii aldolase
C7K43_RS12275	COG0582	viral genome integration into host DNA
C7K43_RS12295	COG0783	Belongs to the Dps family
C7K43_RS12300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K43_RS12310	COG2188	Transcriptional regulator
C7K43_RS12350	COG0662	Cupin 2, conserved barrel domain protein
C7K43_RS12355	COG4619	ABC transporter
C7K43_RS12360	COG0390	transport system, permease component
C7K43_RS12375	COG0783	Belongs to the Dps family
C7K43_RS12380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K43_RS12390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7K43_RS12395	COG2217	Heavy metal translocating P-type atpase
C7K43_RS12440	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
C7K43_RS12495	COG3964	amidohydrolase
C7K43_RS12510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C7K43_RS12515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K43_RS12520	COG2233	PERMEase
C7K43_RS12530	COG0163	prenyltransferase activity
C7K43_RS12535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C7K43_RS12540	COG0583	DNA-binding transcription factor activity
C7K43_RS12545	COG1940	carbohydrate kinase activity
C7K43_RS12550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K43_RS12565	COG3344	reverse transcriptase
C7K43_RS12570	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C7K43_RS12575	COG1120	ATPase activity
C7K43_RS12580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7K43_RS12585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7K43_RS12595	COG0477	Major facilitator Superfamily
C7K43_RS12600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C7K43_RS12605	COG0492	ferredoxin-NADP+ reductase activity
C7K43_RS12615	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C7K43_RS12620	COG1185	polyribonucleotide nucleotidyltransferase activity
C7K43_RS12660	COG0583	DNA-binding transcription factor activity
C7K43_RS12670	COG4221	oxidoreductase activity
C7K43_RS12675	COG0656	L-ascorbic acid biosynthetic process
C7K43_RS12710	COG0745	RESPONSE REGULATOR receiver
C7K43_RS12715	COG2205	protein histidine kinase activity
C7K43_RS12755	COG0798	PFAM Bile acid sodium symporter
C7K43_RS12760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7K43_RS12780	COG1063	alcohol dehydrogenase
C7K43_RS12790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7K43_RS12795	COG2315	Protein conserved in bacteria
C7K43_RS12800	COG0431	NADPH-dependent FMN reductase
C7K43_RS12810	COG0667	Aldo Keto reductase
C7K43_RS12815	COG1028	Short-chain dehydrogenase reductase Sdr
C7K43_RS12820	COG2207	Transcriptional regulator
C7K43_RS12820	COG1917	Cupin 2, conserved barrel domain protein
C7K43_RS12825	COG2814	Major facilitator Superfamily
C7K43_RS12830	COG1063	alcohol dehydrogenase
C7K43_RS12845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C7K43_RS12850	COG0667	Aldo Keto reductase
C7K43_RS12855	COG0789	Transcriptional regulator
C7K43_RS12860	COG0656	L-ascorbic acid biosynthetic process
C7K43_RS12865	COG2188	Transcriptional regulator
C7K43_RS12880	COG3594	Acyltransferase
C7K43_RS12885	COG3579	cysteine-type endopeptidase activity
C7K43_RS12890	COG2814	Major facilitator Superfamily
C7K43_RS12895	COG1823	symporter activity
C7K43_RS12915	COG0582	viral genome integration into host DNA
C7K43_RS12980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD