locus-tag	class	description
C7K38_RS00010	COG3344	reverse transcriptase
C7K38_RS00035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C7K38_RS00040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C7K38_RS00055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7K38_RS00060	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C7K38_RS00085	COG2826	transposase and inactivated derivatives, IS30 family
C7K38_RS00090	COG0745	RESPONSE REGULATOR receiver
C7K38_RS00095	COG5002	protein histidine kinase activity
C7K38_RS00100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7K38_RS00105	COG1950	PFAM Membrane protein of
C7K38_RS00110	COG1983	PspC domain protein
C7K38_RS00120	COG0704	Plays a role in the regulation of phosphate uptake
C7K38_RS00125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7K38_RS00130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7K38_RS00135	COG0581	inorganic phosphate transmembrane transporter activity
C7K38_RS00140	COG0573	inorganic phosphate transmembrane transporter activity
C7K38_RS00145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7K38_RS00150	COG0477	Major facilitator Superfamily
C7K38_RS00155	COG2177	Part of the ABC transporter FtsEX involved in
C7K38_RS00160	COG2884	Cell division ATP-binding protein ftsE
C7K38_RS00170	COG0653	protein targeting
C7K38_RS00180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C7K38_RS00185	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C7K38_RS00190	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K38_RS00200	COG1739	Uncharacterized protein family UPF0029
C7K38_RS00205	COG2188	Transcriptional regulator
C7K38_RS00235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7K38_RS00250	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C7K38_RS00255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7K38_RS00260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C7K38_RS00265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C7K38_RS00270	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7K38_RS00275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7K38_RS00280	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7K38_RS00285	COG0356	it plays a direct role in the translocation of protons across the membrane
C7K38_RS00290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C7K38_RS00295	COG0557	exoribonuclease II activity
C7K38_RS00305	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7K38_RS00310	COG0148	phosphopyruvate hydratase activity
C7K38_RS00315	COG0149	triose-phosphate isomerase activity
C7K38_RS00320	COG0126	phosphoglycerate kinase activity
C7K38_RS00330	COG2390	Transcriptional regulator
C7K38_RS00340	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C7K38_RS00350	COG1668	transmembrane transport
C7K38_RS00355	COG4152	abc transporter atp-binding protein
C7K38_RS00360	COG3343	RNA polymerase activity
C7K38_RS00370	COG0095	Lipoate-protein ligase
C7K38_RS00375	COG1078	dGTPase activity
C7K38_RS00385	COG0346	lactoylglutathione lyase activity
C7K38_RS00395	COG3118	belongs to the thioredoxin family
C7K38_RS00400	COG1193	negative regulation of DNA recombination
C7K38_RS00415	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7K38_RS00425	COG2059	Chromate
C7K38_RS00440	COG1063	alcohol dehydrogenase
C7K38_RS00455	COG4175	Glycine betaine
C7K38_RS00455	COG3448	diguanylate cyclase activity
C7K38_RS00465	COG5646	InterPro IPR014922
C7K38_RS00470	COG1464	Belongs to the NlpA lipoprotein family
C7K38_RS00475	COG3906	Belongs to the UPF0473 family
C7K38_RS00480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C7K38_RS00485	COG4472	Bacterial protein of unknown function (DUF965)
C7K38_RS00490	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C7K38_RS00500	COG0488	(ABC) transporter
C7K38_RS00505	COG3344	reverse transcriptase
C7K38_RS00510	COG0686	Belongs to the AlaDH PNT family
C7K38_RS00515	COG0346	lactoylglutathione lyase activity
C7K38_RS00520	COG0604	alcohol dehydrogenase
C7K38_RS00530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C7K38_RS00535	COG4684	Psort location CytoplasmicMembrane, score
C7K38_RS00540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C7K38_RS00560	COG0802	atpase or kinase
C7K38_RS00565	COG0280	phosphate acetyltransferase
C7K38_RS00570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C7K38_RS00575	COG0561	phosphatase activity
C7K38_RS00595	COG0583	DNA-binding transcription factor activity
C7K38_RS00600	COG1368	sulfuric ester hydrolase activity
C7K38_RS00605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C7K38_RS00610	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C7K38_RS00640	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C7K38_RS00655	COG5002	protein histidine kinase activity
C7K38_RS00660	COG0745	RESPONSE REGULATOR receiver
C7K38_RS00670	COG2226	methyltransferase
C7K38_RS00675	COG0789	Transcriptional regulator
C7K38_RS00680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C7K38_RS00695	COG0583	DNA-binding transcription factor activity
C7K38_RS00705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C7K38_RS00740	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K38_RS00765	COG2249	NAD(P)H dehydrogenase (quinone) activity
C7K38_RS00770	COG1733	regulation of RNA biosynthetic process
C7K38_RS00790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7K38_RS00795	COG0561	phosphatase activity
C7K38_RS00810	COG0604	alcohol dehydrogenase
C7K38_RS00835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7K38_RS00840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C7K38_RS00855	COG0367	asparagine synthase
C7K38_RS00865	COG3443	Belongs to the bacterial solute-binding protein 9 family
C7K38_RS00865	COG0803	Belongs to the bacterial solute-binding protein 9 family
C7K38_RS00870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7K38_RS00895	COG0251	oxidation-reduction process
C7K38_RS00935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C7K38_RS00940	COG2169	Transcriptional regulator
C7K38_RS00945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C7K38_RS00950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C7K38_RS00955	COG2130	NADP-dependent
C7K38_RS00960	COG3344	reverse transcriptase
C7K38_RS00965	COG1811	Na channel or pump
C7K38_RS00970	COG1902	pentaerythritol trinitrate reductase activity
C7K38_RS00980	COG1136	(ABC) transporter
C7K38_RS01000	COG5002	protein histidine kinase activity
C7K38_RS01040	COG1349	DNA-binding transcription factor activity
C7K38_RS01055	COG2390	Transcriptional regulator
C7K38_RS01065	COG3321	synthase
C7K38_RS01065	COG0604	alcohol dehydrogenase
C7K38_RS01065	COG1028	Short-chain dehydrogenase reductase Sdr
C7K38_RS01090	COG3448	diguanylate cyclase activity
C7K38_RS01090	COG4175	Glycine betaine
C7K38_RS01095	COG2188	Transcriptional regulator
C7K38_RS01105	COG0254	rRNA binding
C7K38_RS01115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C7K38_RS01120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7K38_RS01130	COG0504	CTP synthase activity
C7K38_RS01135	COG0174	glutamine synthetase
C7K38_RS01140	COG0789	Transcriptional regulator
C7K38_RS01145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C7K38_RS01150	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C7K38_RS01155	COG0584	glycerophosphoryl diester phosphodiesterase
C7K38_RS01165	COG0740	serine-type endopeptidase activity
C7K38_RS01170	COG0745	RESPONSE REGULATOR receiver
C7K38_RS01175	COG3850	Histidine kinase
C7K38_RS01175	COG5002	protein histidine kinase activity
C7K38_RS01190	COG1132	(ABC) transporter
C7K38_RS01200	COG5503	Protein of unknown function (DUF1447)
C7K38_RS01210	COG1278	Cold shock
C7K38_RS01215	COG2003	Belongs to the UPF0758 family
C7K38_RS01220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K38_RS01225	COG0285	dihydrofolate synthase activity
C7K38_RS01230	COG0525	valine-tRNA ligase activity
C7K38_RS01235	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C7K38_RS01240	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C7K38_RS01245	COG0301	tRNA thio-modification
C7K38_RS01250	COG1104	cysteine desulfurase activity
C7K38_RS01255	COG3344	reverse transcriptase
C7K38_RS01260	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C7K38_RS01265	COG0527	aspartate kinase activity
C7K38_RS01270	COG4166	transmembrane transport
C7K38_RS01275	COG4876	unkown
C7K38_RS01285	COG0561	phosphatase activity
C7K38_RS01290	COG1801	Protein of unknown function DUF72
C7K38_RS01300	COG1823	symporter activity
C7K38_RS01305	COG2814	Major facilitator Superfamily
C7K38_RS01310	COG3579	cysteine-type endopeptidase activity
C7K38_RS01315	COG3594	Acyltransferase
C7K38_RS01325	COG3344	reverse transcriptase
C7K38_RS01355	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C7K38_RS01360	COG2814	Major facilitator Superfamily
C7K38_RS01375	COG0431	NADPH-dependent FMN reductase
C7K38_RS01380	COG2315	Protein conserved in bacteria
C7K38_RS01385	COG1733	regulation of RNA biosynthetic process
C7K38_RS01390	COG1902	pentaerythritol trinitrate reductase activity
C7K38_RS01400	COG2190	(PTS) system
C7K38_RS01400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS01400	COG1263	PTS System
C7K38_RS01405	COG1737	Transcriptional regulator
C7K38_RS01415	COG0789	Transcriptional regulator
C7K38_RS01415	COG4978	Transcriptional regulator
C7K38_RS01420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7K38_RS01440	COG0656	L-ascorbic acid biosynthetic process
C7K38_RS01445	COG0789	Transcriptional regulator
C7K38_RS01450	COG0517	IMP dehydrogenase activity
C7K38_RS01450	COG0516	GMP reductase activity
C7K38_RS01460	COG0411	ABC transporter
C7K38_RS01485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7K38_RS01520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C7K38_RS01535	COG1073	alpha beta
C7K38_RS01540	COG1309	transcriptional regulator
C7K38_RS01570	COG1098	S1 RNA binding domain
C7K38_RS01575	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C7K38_RS01590	COG0492	ferredoxin-NADP+ reductase activity
C7K38_RS01595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C7K38_RS01600	COG0477	Major facilitator Superfamily
C7K38_RS01605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7K38_RS01610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C7K38_RS01615	COG1120	ATPase activity
C7K38_RS01620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C7K38_RS01625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K38_RS01635	COG2233	PERMEase
C7K38_RS01640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K38_RS01645	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C7K38_RS01655	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K38_RS01655	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K38_RS01660	COG2222	sugar isomerase
C7K38_RS01665	COG3716	PTS system mannose fructose sorbose family IID component
C7K38_RS01670	COG3715	PTS system
C7K38_RS01695	COG3732	PTS system glucitol sorbitol-specific
C7K38_RS01700	COG3730	PTS system glucitol sorbitol-specific
C7K38_RS01745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS01750	COG2217	Heavy metal translocating P-type atpase
C7K38_RS01755	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C7K38_RS01760	COG1263	PTS System
C7K38_RS01760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS01765	COG1486	melibiose metabolic process
C7K38_RS01770	COG1737	Transcriptional regulator
C7K38_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
C7K38_RS01785	COG1454	alcohol dehydrogenase
C7K38_RS01795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C7K38_RS01800	COG4297	protein containing double-stranded beta helix domain
C7K38_RS01815	COG2755	lipolytic protein G-D-S-L family
C7K38_RS01815	COG0657	acetylesterase activity
C7K38_RS01820	COG2390	Transcriptional regulator
C7K38_RS01825	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C7K38_RS01830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K38_RS01845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C7K38_RS01850	COG2271	Major facilitator Superfamily
C7K38_RS01855	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C7K38_RS01860	COG3257	ureidoglycine aminohydrolase activity
C7K38_RS01865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K38_RS01870	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C7K38_RS01875	COG0549	Belongs to the carbamate kinase family
C7K38_RS01890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C7K38_RS01895	COG3835	regulator
C7K38_RS01915	COG2873	o-acetylhomoserine
C7K38_RS01940	COG1929	Belongs to the glycerate kinase type-1 family
C7K38_RS01945	COG4948	Mandelate Racemase Muconate Lactonizing
C7K38_RS01955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7K38_RS01960	COG4948	Mandelate Racemase Muconate Lactonizing
C7K38_RS01965	COG2084	Dehydrogenase
C7K38_RS01970	COG2721	sulfolactate sulfo-lyase activity
C7K38_RS01975	COG2610	gluconate transmembrane transporter activity
C7K38_RS01990	COG1012	belongs to the aldehyde dehydrogenase family
C7K38_RS02000	COG1131	(ABC) transporter
C7K38_RS02005	COG1131	(ABC) transporter
C7K38_RS02010	COG1309	transcriptional regulator
C7K38_RS02015	COG3711	transcriptional antiterminator
C7K38_RS02020	COG2723	6-phospho-beta-galactosidase activity
C7K38_RS02025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS02025	COG1263	PTS System
C7K38_RS02025	COG2190	(PTS) system
C7K38_RS02040	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C7K38_RS02060	COG1914	H( )-stimulated, divalent metal cation uptake system
C7K38_RS02065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C7K38_RS02070	COG4821	SIS domain
C7K38_RS02075	COG3716	PTS system mannose fructose sorbose family IID component
C7K38_RS02080	COG3715	PTS system
C7K38_RS02085	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS02095	COG1396	sequence-specific DNA binding
C7K38_RS02110	COG0383	alpha-mannosidase activity
C7K38_RS02115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS02115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS02115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS02120	COG1737	Transcriptional regulator
C7K38_RS02125	COG1263	PTS System
C7K38_RS02125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS02130	COG3394	polysaccharide catabolic process
C7K38_RS02135	COG1486	melibiose metabolic process
C7K38_RS02140	COG1737	Transcriptional regulator
C7K38_RS02170	COG3716	PTS system mannose fructose sorbose family IID component
C7K38_RS02175	COG3715	PTS system
C7K38_RS02180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS02190	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K38_RS02190	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K38_RS02200	COG2826	transposase and inactivated derivatives, IS30 family
C7K38_RS02205	COG0668	transmembrane transport
C7K38_RS02220	COG1953	Uracil, thiamine, allantoin
C7K38_RS02230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C7K38_RS02235	COG0405	Gamma-glutamyltransferase
C7K38_RS02245	COG2188	Transcriptional regulator
C7K38_RS02255	COG2723	6-phospho-beta-galactosidase activity
C7K38_RS02265	COG3976	FMN-binding domain protein
C7K38_RS02265	COG1053	succinate dehydrogenase
C7K38_RS02265	COG0431	NADPH-dependent FMN reductase
C7K38_RS02295	COG0318	PFAM AMP-dependent synthetase and ligase
C7K38_RS02300	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C7K38_RS02305	COG2050	protein possibly involved in aromatic compounds catabolism
C7K38_RS02310	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C7K38_RS02315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS02315	COG1263	PTS System
C7K38_RS02330	COG0383	alpha-mannosidase activity
C7K38_RS02335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS02340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS02340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS02340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS02345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS02345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS02345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS02350	COG3711	transcriptional antiterminator
C7K38_RS02350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS02365	COG1263	PTS System
C7K38_RS02365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS02400	COG3344	reverse transcriptase
C7K38_RS02420	COG2814	Major facilitator Superfamily
C7K38_RS02460	COG1454	alcohol dehydrogenase
C7K38_RS02465	COG1012	belongs to the aldehyde dehydrogenase family
C7K38_RS02470	COG1510	regulation of RNA biosynthetic process
C7K38_RS02475	COG2113	Glycine betaine
C7K38_RS02510	COG2188	Transcriptional regulator
C7K38_RS02520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K38_RS02525	COG0783	Belongs to the Dps family
C7K38_RS02550	COG0582	viral genome integration into host DNA
C7K38_RS02555	COG2217	Heavy metal translocating P-type atpase
C7K38_RS02580	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
C7K38_RS02645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K38_RS02650	COG0783	Belongs to the Dps family
C7K38_RS02665	COG0390	transport system, permease component
C7K38_RS02670	COG4619	ABC transporter
C7K38_RS02675	COG0662	Cupin 2, conserved barrel domain protein
C7K38_RS02710	COG0300	oxidoreductase activity
C7K38_RS02715	COG2723	6-phospho-beta-galactosidase activity
C7K38_RS02720	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K38_RS02750	COG0438	transferase activity, transferring glycosyl groups
C7K38_RS02760	COG1215	transferase activity, transferring glycosyl groups
C7K38_RS02765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7K38_RS02770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C7K38_RS02785	COG3385	transposase activity
C7K38_RS02795	COG4464	protein tyrosine phosphatase activity
C7K38_RS02800	COG0489	protein tyrosine kinase activity
C7K38_RS02810	COG1316	TRANSCRIPTIONal
C7K38_RS02820	COG3942	CHAP domain
C7K38_RS02820	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7K38_RS02825	COG0628	permease
C7K38_RS02835	COG2249	NAD(P)H dehydrogenase (quinone) activity
C7K38_RS02845	COG3344	reverse transcriptase
C7K38_RS02850	COG2261	transglycosylase associated protein
C7K38_RS02855	COG5039	Polysaccharide pyruvyl transferase
C7K38_RS02860	COG5039	Polysaccharide pyruvyl transferase
C7K38_RS02875	COG3448	diguanylate cyclase activity
C7K38_RS02875	COG4175	Glycine betaine
C7K38_RS02900	COG1472	Belongs to the glycosyl hydrolase 3 family
C7K38_RS02905	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C7K38_RS02910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C7K38_RS02915	COG1288	antiporter activity
C7K38_RS02935	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C7K38_RS02940	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C7K38_RS02945	COG0084	hydrolase, TatD family'
C7K38_RS02950	COG1408	metallophosphoesterase
C7K38_RS02985	COG0531	amino acid
C7K38_RS02995	COG3001	Fructosamine kinase
C7K38_RS03000	COG1028	Short-chain dehydrogenase reductase Sdr
C7K38_RS03015	COG3012	SEC-C Motif Domain Protein
C7K38_RS03020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C7K38_RS03025	COG4109	DRTGG domain
C7K38_RS03030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C7K38_RS03035	COG0363	glucosamine-6-phosphate deaminase activity
C7K38_RS03040	COG0246	Mannitol dehydrogenase
C7K38_RS03045	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS03050	COG3711	transcriptional antiterminator
C7K38_RS03055	COG2213	PTS system mannitol-specific
C7K38_RS03075	COG1428	Deoxynucleoside kinase
C7K38_RS03085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7K38_RS03090	COG0366	Alpha amylase catalytic
C7K38_RS03095	COG1136	(ABC) transporter
C7K38_RS03095	COG0577	efflux transmembrane transporter activity
C7K38_RS03095	COG0577	efflux transmembrane transporter activity
C7K38_RS03095	COG1136	(ABC) transporter
C7K38_RS03100	COG0488	(ABC) transporter
C7K38_RS03120	COG1695	Transcriptional regulator
C7K38_RS03130	COG1940	carbohydrate kinase activity
C7K38_RS03145	COG1054	Belongs to the UPF0176 family
C7K38_RS03155	COG1394	ATPase activity, coupled to movement of substances
C7K38_RS03160	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C7K38_RS03165	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C7K38_RS03175	COG1527	subunit (C
C7K38_RS03180	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
C7K38_RS03185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7K38_RS03190	COG1269	ATP hydrolysis coupled proton transport
C7K38_RS03205	COG1285	pathogenesis
C7K38_RS03220	COG2217	Heavy metal translocating P-type atpase
C7K38_RS03230	COG0702	epimerase
C7K38_RS03265	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS03275	COG3684	Belongs to the aldolase LacD family
C7K38_RS03280	COG2222	sugar isomerase
C7K38_RS03285	COG2188	Transcriptional regulator
C7K38_RS03290	COG1461	Dihydroxyacetone kinase
C7K38_RS03295	COG2376	Dihydroxyacetone kinase
C7K38_RS03300	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C7K38_RS03305	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K38_RS03315	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C7K38_RS03325	COG3344	reverse transcriptase
C7K38_RS03330	COG3118	belongs to the thioredoxin family
C7K38_RS03335	COG0386	Belongs to the glutathione peroxidase family
C7K38_RS03340	COG1846	Transcriptional regulator
C7K38_RS03345	COG0492	ferredoxin-NADP+ reductase activity
C7K38_RS03370	COG0322	excinuclease ABC activity
C7K38_RS03375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7K38_RS03380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C7K38_RS03385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C7K38_RS03390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K38_RS03395	COG0589	response to stress
C7K38_RS03400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C7K38_RS03405	COG1363	Peptidase, m42
C7K38_RS03420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C7K38_RS03425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C7K38_RS03430	COG0827	DNA restriction-modification system
C7K38_RS03455	COG4537	Required for transformation and DNA binding
C7K38_RS03460	COG1459	type II secretion system
C7K38_RS03465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C7K38_RS03470	COG2755	lipolytic protein G-D-S-L family
C7K38_RS03470	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C7K38_RS03475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C7K38_RS03480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C7K38_RS03485	COG0124	histidyl-tRNA synthetase
C7K38_RS03490	COG0824	Thioesterase
C7K38_RS03500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C7K38_RS03505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C7K38_RS03510	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C7K38_RS03515	COG4166	transmembrane transport
C7K38_RS03520	COG2508	Transcriptional regulator
C7K38_RS03525	COG0402	S-adenosylhomocysteine deaminase activity
C7K38_RS03530	COG0402	S-adenosylhomocysteine deaminase activity
C7K38_RS03535	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K38_RS03540	COG1428	Deoxynucleoside kinase
C7K38_RS03560	COG1304	FMN binding
C7K38_RS03570	COG0343	queuine tRNA-ribosyltransferase activity
C7K38_RS03585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C7K38_RS03610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C7K38_RS03625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7K38_RS03630	COG0736	holo-[acyl-carrier-protein] synthase activity
C7K38_RS03645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7K38_RS03650	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7K38_RS03655	COG1671	Belongs to the UPF0178 family
C7K38_RS03675	COG0572	uridine kinase
C7K38_RS03680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C7K38_RS03685	COG0509	glycine decarboxylation via glycine cleavage system
C7K38_RS03690	COG1393	Belongs to the ArsC family
C7K38_RS03695	COG0772	Belongs to the SEDS family
C7K38_RS03705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C7K38_RS03710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C7K38_RS03715	COG0009	L-threonylcarbamoyladenylate synthase
C7K38_RS03720	COG2890	protein-(glutamine-N5) methyltransferase activity
C7K38_RS03725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C7K38_RS03730	COG1435	thymidine kinase activity
C7K38_RS03745	COG0071	Belongs to the small heat shock protein (HSP20) family
C7K38_RS03750	COG0514	ATP-dependent DNA helicase (RecQ)
C7K38_RS03755	COG0681	Belongs to the peptidase S26 family
C7K38_RS03760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C7K38_RS03765	COG1395	domain, Protein
C7K38_RS03770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7K38_RS03775	COG3442	glutamine amidotransferase
C7K38_RS03780	COG1263	PTS System
C7K38_RS03780	COG2190	(PTS) system
C7K38_RS03780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS03790	COG1482	cell wall glycoprotein biosynthetic process
C7K38_RS03795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7K38_RS03805	COG0537	adenosine 5'-monophosphoramidase activity
C7K38_RS03815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7K38_RS03820	COG3481	metal-dependent phosphohydrolase, HD sub domain
C7K38_RS03840	COG3679	Belongs to the UPF0342 family
C7K38_RS03845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7K38_RS03850	COG0564	pseudouridine synthase activity
C7K38_RS03855	COG1187	pseudouridine synthase activity
C7K38_RS03860	COG2244	polysaccharide biosynthetic process
C7K38_RS03865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C7K38_RS03875	COG1764	response to oxidative stress
C7K38_RS03880	COG1929	Belongs to the glycerate kinase type-1 family
C7K38_RS03885	COG0495	leucyl-tRNA aminoacylation
C7K38_RS03890	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7K38_RS03890	COG1388	LysM domain
C7K38_RS03895	COG0671	phosphoesterase, PA-phosphatase related
C7K38_RS03900	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C7K38_RS03920	COG3775	system Galactitol-specific IIC component
C7K38_RS03925	COG3414	Phosphotransferase system galactitol-specific IIB component
C7K38_RS03930	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C7K38_RS03935	COG0693	protein deglycase activity
C7K38_RS03945	COG0488	(ABC) transporter
C7K38_RS03950	COG1464	Belongs to the NlpA lipoprotein family
C7K38_RS03955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7K38_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
C7K38_RS03975	COG2723	6-phospho-beta-galactosidase activity
C7K38_RS03985	COG2205	protein histidine kinase activity
C7K38_RS04000	COG0745	RESPONSE REGULATOR receiver
C7K38_RS04010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7K38_RS04015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C7K38_RS04055	COG0142	geranyltranstransferase activity
C7K38_RS04060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7K38_RS04065	COG0456	acetyltransferase
C7K38_RS04075	COG0542	response to heat
C7K38_RS04080	COG4463	regulation of RNA biosynthetic process
C7K38_RS04085	COG2815	serine threonine protein kinase
C7K38_RS04085	COG0515	serine threonine protein kinase
C7K38_RS04095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7K38_RS04095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7K38_RS04100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7K38_RS04105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C7K38_RS04110	COG1758	RNA polymerase activity
C7K38_RS04115	COG0194	GDP metabolic process
C7K38_RS04120	COG4443	Transcriptional Coactivator p15 (PC4)
C7K38_RS04135	COG0351	phosphomethylpyrimidine kinase
C7K38_RS04145	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C7K38_RS04160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7K38_RS04165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C7K38_RS04170	COG0105	UTP biosynthetic process
C7K38_RS04175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7K38_RS04180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C7K38_RS04185	COG1121	(ABC) transporter
C7K38_RS04190	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C7K38_RS04195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS04195	COG1263	PTS System
C7K38_RS04200	COG1554	hydrolase, family 65, central catalytic
C7K38_RS04205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K38_RS04210	COG2188	Transcriptional regulator
C7K38_RS04215	COG1418	mRNA catabolic process
C7K38_RS04220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C7K38_RS04225	COG1058	Belongs to the CinA family
C7K38_RS04225	COG1546	Belongs to the CinA family
C7K38_RS04230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C7K38_RS04235	COG1426	Protein conserved in bacteria
C7K38_RS04245	COG0612	Peptidase, M16
C7K38_RS04250	COG0612	Peptidase, M16
C7K38_RS04255	COG1970	mechanosensitive ion channel activity
C7K38_RS04260	COG4466	Protein conserved in bacteria
C7K38_RS04270	COG3688	RNA-binding protein containing a PIN domain
C7K38_RS04275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7K38_RS04280	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C7K38_RS04285	COG0215	cysteine-tRNA ligase activity
C7K38_RS04290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7K38_RS04295	COG4956	integral membrane protein (PIN domain superfamily)
C7K38_RS04305	COG0756	dUTP diphosphatase activity
C7K38_RS04310	COG0656	L-ascorbic acid biosynthetic process
C7K38_RS04315	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C7K38_RS04320	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C7K38_RS04340	COG0488	(ABC) transporter
C7K38_RS04350	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C7K38_RS04355	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C7K38_RS04360	COG0305	Participates in initiation and elongation during chromosome replication
C7K38_RS04365	COG0359	binds to the 23S rRNA
C7K38_RS04375	COG3344	reverse transcriptase
C7K38_RS04380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7K38_RS04390	COG0360	Binds together with S18 to 16S ribosomal RNA
C7K38_RS04400	COG0187	DNA topoisomerase II activity
C7K38_RS04405	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C7K38_RS04415	COG3344	reverse transcriptase
C7K38_RS04420	COG0592	DNA-directed DNA polymerase activity
C7K38_RS04425	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7K38_RS04435	COG0594	ribonuclease P activity
C7K38_RS04440	COG0706	membrane insertase activity
C7K38_RS04455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C7K38_RS04460	COG0445	tRNA wobble uridine modification
C7K38_RS04465	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C7K38_RS04480	COG0583	DNA-binding transcription factor activity
C7K38_RS04485	COG1380	Effector of murein hydrolase LrgA
C7K38_RS04490	COG1346	cytolysis
C7K38_RS04495	COG1304	FMN binding
C7K38_RS04520	COG1442	glycosyl transferase family 8
C7K38_RS04535	COG0357	Ribosomal RNA small subunit methyltransferase G
C7K38_RS04540	COG1192	Involved in chromosome partitioning
C7K38_RS04545	COG1475	DNA binding
C7K38_RS04550	COG4481	Protein conserved in bacteria
C7K38_RS04555	COG0012	GTP binding
C7K38_RS04565	COG0516	GMP reductase activity
C7K38_RS04565	COG0517	IMP dehydrogenase activity
C7K38_RS04570	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C7K38_RS04645	COG1162	GTPase activity
C7K38_RS04650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K38_RS04675	COG3344	reverse transcriptase
C7K38_RS04680	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C7K38_RS04685	COG0783	Belongs to the Dps family
C7K38_RS04690	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C7K38_RS04695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C7K38_RS04700	COG2267	carboxylic ester hydrolase activity
C7K38_RS04715	COG1349	DNA-binding transcription factor activity
C7K38_RS04745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7K38_RS04760	COG1438	arginine binding
C7K38_RS04765	COG2235	arginine
C7K38_RS04770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C7K38_RS04780	COG2153	protein acetylation
C7K38_RS04785	COG0018	arginyl-trna synthetase
C7K38_RS04790	COG4975	Glucose uptake
C7K38_RS04805	COG1271	oxidase subunit
C7K38_RS04810	COG1294	oxidase, subunit
C7K38_RS04815	COG4988	ABC transporter
C7K38_RS04820	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C7K38_RS04830	COG0803	Belongs to the bacterial solute-binding protein 9 family
C7K38_RS04830	COG3443	Belongs to the bacterial solute-binding protein 9 family
C7K38_RS04840	COG4166	transmembrane transport
C7K38_RS04865	COG1252	NADH dehydrogenase
C7K38_RS04875	COG2814	Major facilitator Superfamily
C7K38_RS04885	COG1012	belongs to the aldehyde dehydrogenase family
C7K38_RS04890	COG2814	Major facilitator Superfamily
C7K38_RS04900	COG0217	transcriptional regulatory protein
C7K38_RS04910	COG0039	L-malate dehydrogenase activity
C7K38_RS04915	COG0193	aminoacyl-tRNA hydrolase activity
C7K38_RS04920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C7K38_RS04925	COG2244	polysaccharide biosynthetic process
C7K38_RS04930	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C7K38_RS04940	COG1098	S1 RNA binding domain
C7K38_RS04945	COG0037	tRNA processing
C7K38_RS04950	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C7K38_RS04955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7K38_RS04960	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C7K38_RS04965	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C7K38_RS05115	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C7K38_RS05130	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C7K38_RS05135	COG1263	PTS System
C7K38_RS05135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS05145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C7K38_RS05150	COG1737	Transcriptional regulator
C7K38_RS05155	COG0039	L-malate dehydrogenase activity
C7K38_RS05165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C7K38_RS05190	COG1309	transcriptional regulator
C7K38_RS05195	COG4591	ABC-type transport system involved in lipoprotein release permease component
C7K38_RS05195	COG1136	(ABC) transporter
C7K38_RS05210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C7K38_RS05215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7K38_RS05220	COG0435	Glutathione S-transferase
C7K38_RS05225	COG3344	reverse transcriptase
C7K38_RS05230	COG0714	Associated with various cellular activities
C7K38_RS05240	COG1305	Transglutaminase-like
C7K38_RS05245	COG2340	Cysteine-rich secretory protein family
C7K38_RS05255	COG2190	(PTS) system
C7K38_RS05255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS05255	COG1263	PTS System
C7K38_RS05270	COG1388	LysM domain
C7K38_RS05275	COG1968	undecaprenyl-diphosphatase activity
C7K38_RS05280	COG4585	Histidine kinase
C7K38_RS05285	COG2197	response regulator
C7K38_RS05300	COG1286	toxin biosynthetic process
C7K38_RS05305	COG0789	Transcriptional regulator
C7K38_RS05315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7K38_RS05325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7K38_RS05330	COG0625	glutathione transferase activity
C7K38_RS05335	COG0693	protein deglycase activity
C7K38_RS05340	COG0765	amino acid transport
C7K38_RS05350	COG1126	abc transporter atp-binding protein
C7K38_RS05360	COG0561	phosphatase activity
C7K38_RS05365	COG0471	metal ion transport
C7K38_RS05370	COG0628	permease
C7K38_RS05375	COG0708	Exodeoxyribonuclease III
C7K38_RS05405	COG2153	protein acetylation
C7K38_RS05430	COG1114	Component of the transport system for branched-chain amino acids
C7K38_RS05460	COG3708	Transcriptional regulator
C7K38_RS05460	COG2207	Transcriptional regulator
C7K38_RS05465	COG0693	protein deglycase activity
C7K38_RS05470	COG0519	Catalyzes the synthesis of GMP from XMP
C7K38_RS05470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C7K38_RS05475	COG1072	(Pantothenic acid kinase))
C7K38_RS05480	COG2813	Specifically methylates the guanine in position
C7K38_RS05485	COG1609	Transcriptional regulator
C7K38_RS05490	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C7K38_RS05495	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K38_RS05500	COG0295	cytidine deaminase activity
C7K38_RS05505	COG1744	ABC transporter substrate-binding protein PnrA-like
C7K38_RS05510	COG3845	ABC transporter
C7K38_RS05515	COG4603	Belongs to the binding-protein-dependent transport system permease family
C7K38_RS05520	COG1079	Belongs to the binding-protein-dependent transport system permease family
C7K38_RS05525	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C7K38_RS05530	COG0813	purine-nucleoside phosphorylase activity
C7K38_RS05535	COG1979	alcohol dehydrogenase
C7K38_RS05540	COG0588	phosphoglycerate mutase activity
C7K38_RS05550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C7K38_RS05555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C7K38_RS05560	COG0049	tRNA binding
C7K38_RS05565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7K38_RS05570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C7K38_RS05575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C7K38_RS05590	COG0051	transcription antitermination factor activity, RNA binding
C7K38_RS05595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C7K38_RS05600	COG0088	Forms part of the polypeptide exit tunnel
C7K38_RS05605	COG0089	rRNA binding
C7K38_RS05610	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C7K38_RS05615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C7K38_RS05620	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C7K38_RS05625	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C7K38_RS05635	COG0255	Belongs to the universal ribosomal protein uL29 family
C7K38_RS05640	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C7K38_RS05645	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C7K38_RS05650	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C7K38_RS05655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C7K38_RS05660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7K38_RS05665	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C7K38_RS05670	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C7K38_RS05675	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C7K38_RS05680	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C7K38_RS05685	COG1841	ribosomal large subunit assembly
C7K38_RS05690	COG0200	Binds to the 23S rRNA
C7K38_RS05700	COG0563	adenylate kinase activity
C7K38_RS05705	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C7K38_RS05710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7K38_RS05715	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C7K38_RS05725	COG0202	RNA polymerase activity
C7K38_RS05730	COG0203	ribosomal protein L17
C7K38_RS05735	COG1122	ATPase activity
C7K38_RS05740	COG1122	ATPase activity
C7K38_RS05750	COG0101	tRNA pseudouridine synthase activity
C7K38_RS05780	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C7K38_RS05810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7K38_RS05820	COG1461	Dihydroxyacetone kinase
C7K38_RS05825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7K38_RS05830	COG0416	fatty acid biosynthetic process
C7K38_RS05835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7K38_RS05840	COG0571	ribonuclease III activity
C7K38_RS05845	COG1196	nuclear chromosome segregation
C7K38_RS05850	COG0561	phosphatase activity
C7K38_RS05855	COG0552	protein localization to endoplasmic reticulum
C7K38_RS05860	COG2918	glutathione biosynthetic process
C7K38_RS05860	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7K38_RS05875	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C7K38_RS05880	COG4493	Belongs to the UPF0637 family
C7K38_RS05885	COG1268	BioY protein
C7K38_RS05890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C7K38_RS05905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C7K38_RS05910	COG0561	phosphatase activity
C7K38_RS05930	COG1692	metallophosphoesterase
C7K38_RS05935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C7K38_RS05970	COG2255	four-way junction helicase activity
C7K38_RS05975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7K38_RS05985	COG1114	Component of the transport system for branched-chain amino acids
C7K38_RS05990	COG1126	abc transporter atp-binding protein
C7K38_RS05995	COG0765	amino acid transport
C7K38_RS06005	COG0110	maltose O-acetyltransferase activity
C7K38_RS06010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C7K38_RS06015	COG2011	ABC-type metal ion transport system permease component
C7K38_RS06020	COG1464	Belongs to the NlpA lipoprotein family
C7K38_RS06025	COG0242	peptide deformylase activity
C7K38_RS06040	COG1132	(ABC) transporter
C7K38_RS06045	COG1131	(ABC) transporter
C7K38_RS06060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C7K38_RS06065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K38_RS06075	COG1447	Phosphotransferase system cellobiose-specific component IIA
C7K38_RS06085	COG2723	6-phospho-beta-galactosidase activity
C7K38_RS06090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS06090	COG3711	transcriptional antiterminator
C7K38_RS06100	COG0656	L-ascorbic acid biosynthetic process
C7K38_RS06105	COG3344	reverse transcriptase
C7K38_RS06115	COG1611	Belongs to the LOG family
C7K38_RS06125	COG0656	L-ascorbic acid biosynthetic process
C7K38_RS06130	COG0561	phosphatase activity
C7K38_RS06135	COG1131	(ABC) transporter
C7K38_RS06145	COG0589	response to stress
C7K38_RS06165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7K38_RS06170	COG2094	Belongs to the DNA glycosylase MPG family
C7K38_RS06175	COG2264	protein methyltransferase activity
C7K38_RS06180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C7K38_RS06185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C7K38_RS06190	COG1490	D-aminoacyl-tRNA deacylase activity
C7K38_RS06195	COG3344	reverse transcriptase
C7K38_RS06210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7K38_RS06220	COG0531	amino acid
C7K38_RS06225	COG3853	Toxic anion resistance protein (TelA)
C7K38_RS06245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7K38_RS06250	COG3590	peptidase
C7K38_RS06255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C7K38_RS06260	COG1104	cysteine desulfurase activity
C7K38_RS06270	COG0482	sulfurtransferase activity
C7K38_RS06300	COG3842	ATPase activity
C7K38_RS06305	COG2508	Transcriptional regulator
C7K38_RS06310	COG0765	amino acid transport
C7K38_RS06315	COG1126	abc transporter atp-binding protein
C7K38_RS06320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K38_RS06325	COG1280	lysine exporter protein (LysE YggA)
C7K38_RS06325	COG1674	ftsk spoiiie
C7K38_RS06330	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7K38_RS06335	COG4166	transmembrane transport
C7K38_RS06345	COG0601	transmembrane transport
C7K38_RS06350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7K38_RS06355	COG0444	Belongs to the ABC transporter superfamily
C7K38_RS06360	COG4608	Belongs to the ABC transporter superfamily
C7K38_RS06370	COG2239	Acts as a magnesium transporter
C7K38_RS06385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K38_RS06385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K38_RS06390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7K38_RS06405	COG0488	(ABC) transporter
C7K38_RS06410	COG2706	6-phosphogluconolactonase activity
C7K38_RS06420	COG0628	permease
C7K38_RS06425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7K38_RS06430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C7K38_RS06435	COG1185	polyribonucleotide nucleotidyltransferase activity
C7K38_RS06455	COG0719	Fe-S assembly protein
C7K38_RS06460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7K38_RS06470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C7K38_RS06475	COG1132	(ABC) transporter
C7K38_RS06480	COG1132	(ABC) transporter
C7K38_RS06490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7K38_RS06525	COG2610	gluconate transmembrane transporter activity
C7K38_RS06530	COG1070	Carbohydrate kinase
C7K38_RS06535	COG4221	oxidoreductase activity
C7K38_RS06535	COG3321	synthase
C7K38_RS06535	COG0604	alcohol dehydrogenase
C7K38_RS06535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7K38_RS06540	COG0431	NADPH-dependent FMN reductase
C7K38_RS06540	COG1053	succinate dehydrogenase
C7K38_RS06540	COG3976	FMN-binding domain protein
C7K38_RS06550	COG1428	Deoxynucleoside kinase
C7K38_RS06555	COG3104	oligopeptide transport
C7K38_RS06565	COG1132	(ABC) transporter
C7K38_RS06570	COG1174	glycine betaine transport
C7K38_RS06575	COG0517	IMP dehydrogenase activity
C7K38_RS06575	COG1125	glycine betaine transport
C7K38_RS06585	COG2226	methyltransferase
C7K38_RS06605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7K38_RS06610	COG3527	Alpha-acetolactate decarboxylase
C7K38_RS06620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7K38_RS06625	COG0626	cystathionine gamma-synthase activity
C7K38_RS06630	COG1045	serine acetyltransferase
C7K38_RS06635	COG0095	Lipoate-protein ligase
C7K38_RS06640	COG0025	NhaP-type Na H and K H
C7K38_RS06650	COG3711	transcriptional antiterminator
C7K38_RS06650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS06655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS06655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7K38_RS06655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS06660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS06675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K38_RS06685	COG0719	Fe-S assembly protein
C7K38_RS06690	COG0716	FMN binding
C7K38_RS06695	COG0028	Belongs to the TPP enzyme family
C7K38_RS06710	COG2171	N-acyltransferase activity
C7K38_RS06715	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C7K38_RS06720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7K38_RS06725	COG1473	amidohydrolase
C7K38_RS06730	COG0019	diaminopimelate decarboxylase activity
C7K38_RS06735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C7K38_RS06740	COG2738	Putative neutral zinc metallopeptidase
C7K38_RS06750	COG0590	tRNA wobble adenosine to inosine editing
C7K38_RS06765	COG0737	Belongs to the 5'-nucleotidase family
C7K38_RS06770	COG4470	Protein conserved in bacteria
C7K38_RS06775	COG0647	UMP catabolic process
C7K38_RS06785	COG0095	Lipoate-protein ligase
C7K38_RS06795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7K38_RS06800	COG4656	Part of a membrane complex involved in electron transport
C7K38_RS06805	COG4658	electron transport chain
C7K38_RS06815	COG1131	(ABC) transporter
C7K38_RS06820	COG1309	transcriptional regulator
C7K38_RS06825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7K38_RS06830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7K38_RS06835	COG2827	Endonuclease containing a URI domain
C7K38_RS06840	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C7K38_RS06855	COG0204	Acyl-transferase
C7K38_RS06860	COG0420	3'-5' exonuclease activity
C7K38_RS06865	COG0419	ATPase involved in DNA repair
C7K38_RS06870	COG0419	ATPase involved in DNA repair
C7K38_RS06875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7K38_RS06880	COG1393	Belongs to the ArsC family
C7K38_RS06885	COG4862	establishment of competence for transformation
C7K38_RS06905	COG4116	CYTH
C7K38_RS06910	COG2357	RelA SpoT domain protein
C7K38_RS06915	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C7K38_RS06920	COG0564	pseudouridine synthase activity
C7K38_RS06925	COG2239	Acts as a magnesium transporter
C7K38_RS06930	COG3142	Participates in the control of copper homeostasis
C7K38_RS06935	COG0500	methyltransferase
C7K38_RS06940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C7K38_RS06950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7K38_RS06955	COG1597	lipid kinase activity
C7K38_RS06965	COG4708	membrane
C7K38_RS06975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7K38_RS06980	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7K38_RS06985	COG0250	Participates in transcription elongation, termination and antitermination
C7K38_RS06990	COG3344	reverse transcriptase
C7K38_RS07005	COG0081	regulation of translation
C7K38_RS07010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C7K38_RS07015	COG0222	ribosome binding
C7K38_RS07020	COG2910	NAD(P)H-binding
C7K38_RS07025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K38_RS07030	COG2723	6-phospho-beta-galactosidase activity
C7K38_RS07035	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C7K38_RS07040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C7K38_RS07045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C7K38_RS07050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C7K38_RS07055	COG3870	Protein conserved in bacteria
C7K38_RS07060	COG0470	DNA polymerase III
C7K38_RS07065	COG4467	Involved in initiation control of chromosome replication
C7K38_RS07090	COG1328	CTP reductase activity
C7K38_RS07095	COG0095	Lipoate-protein ligase
C7K38_RS07100	COG0656	L-ascorbic acid biosynthetic process
C7K38_RS07105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7K38_RS07110	COG4122	O-methyltransferase activity
C7K38_RS07120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7K38_RS07130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C7K38_RS07140	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C7K38_RS07140	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7K38_RS07145	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS07145	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS07155	COG3715	PTS system
C7K38_RS07160	COG3716	PTS system mannose fructose sorbose family IID component
C7K38_RS07175	COG4864	UPF0365 protein
C7K38_RS07185	COG0006	proline dipeptidase activity
C7K38_RS07190	COG1302	Protein conserved in bacteria
C7K38_RS07195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7K38_RS07200	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C7K38_RS07205	COG1570	exodeoxyribonuclease VII activity
C7K38_RS07210	COG1722	exodeoxyribonuclease VII activity
C7K38_RS07215	COG0142	geranyltranstransferase activity
C7K38_RS07220	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C7K38_RS07225	COG1438	arginine binding
C7K38_RS07230	COG0497	DNA recombination
C7K38_RS07255	COG2001	Belongs to the MraZ family
C7K38_RS07260	COG0275	rRNA processing
C7K38_RS07270	COG0768	penicillin binding
C7K38_RS07280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7K38_RS07305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C7K38_RS07310	COG1799	cell septum assembly
C7K38_RS07315	COG0762	integral membrane protein
C7K38_RS07320	COG2302	S4 RNA-binding domain
C7K38_RS07325	COG3599	regulation of cell shape
C7K38_RS07330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C7K38_RS07335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C7K38_RS07345	COG2309	aminopeptidase activity
C7K38_RS07350	COG1309	transcriptional regulator
C7K38_RS07355	COG0716	FMN binding
C7K38_RS07360	COG0024	Methionine aminopeptidase
C7K38_RS07380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7K38_RS07385	COG3682	Transcriptional regulator
C7K38_RS07390	COG2608	mercury ion transmembrane transporter activity
C7K38_RS07400	COG0436	Aminotransferase
C7K38_RS07405	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C7K38_RS07410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C7K38_RS07425	COG2826	transposase and inactivated derivatives, IS30 family
C7K38_RS07435	COG0655	NAD(P)H dehydrogenase (quinone) activity
C7K38_RS07440	COG0431	NADPH-dependent FMN reductase
C7K38_RS07445	COG0228	four-way junction DNA binding
C7K38_RS07450	COG1837	Belongs to the UPF0109 family
C7K38_RS07460	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C7K38_RS07470	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
C7K38_RS07475	COG3052	prosthetic group binding
C7K38_RS07510	COG0336	Belongs to the RNA methyltransferase TrmD family
C7K38_RS07515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C7K38_RS07525	COG3830	Belongs to the UPF0237 family
C7K38_RS07530	COG2848	UPF0210 protein
C7K38_RS07535	COG1956	GAF domain-containing protein
C7K38_RS07545	COG0582	viral genome integration into host DNA
C7K38_RS07560	COG2826	transposase and inactivated derivatives, IS30 family
C7K38_RS07570	COG0745	RESPONSE REGULATOR receiver
C7K38_RS07575	COG5002	protein histidine kinase activity
C7K38_RS07575	COG3850	Histidine kinase
C7K38_RS07590	COG1368	sulfuric ester hydrolase activity
C7K38_RS07595	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C7K38_RS07600	COG0710	3-dehydroquinate dehydratase activity
C7K38_RS07605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7K38_RS07610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C7K38_RS07615	COG0166	Belongs to the GPI family
C7K38_RS07645	COG0561	phosphatase activity
C7K38_RS07655	COG2252	PERMEase
C7K38_RS07665	COG0587	DNA-directed DNA polymerase activity
C7K38_RS07670	COG0205	6-phosphofructokinase activity
C7K38_RS07680	COG1399	metal-binding, possibly nucleic acid-binding protein
C7K38_RS07685	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7K38_RS07690	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C7K38_RS07695	COG0745	RESPONSE REGULATOR receiver
C7K38_RS07700	COG5002	protein histidine kinase activity
C7K38_RS07785	COG2826	transposase and inactivated derivatives, IS30 family
C7K38_RS07800	COG5504	Zn-dependent protease
C7K38_RS07815	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS07820	COG3715	PTS system
C7K38_RS07825	COG3716	PTS system mannose fructose sorbose family IID component
C7K38_RS07830	COG0246	Mannitol dehydrogenase
C7K38_RS07835	COG0246	Mannitol dehydrogenase
C7K38_RS07840	COG3079	Belongs to the UPF0149 family
C7K38_RS07845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7K38_RS07850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C7K38_RS07855	COG0251	oxidation-reduction process
C7K38_RS07860	COG1464	Belongs to the NlpA lipoprotein family
C7K38_RS07885	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7K38_RS07885	COG3942	CHAP domain
C7K38_RS07900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS07900	COG1263	PTS System
C7K38_RS07905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C7K38_RS07910	COG1349	DNA-binding transcription factor activity
C7K38_RS07915	COG1482	cell wall glycoprotein biosynthetic process
C7K38_RS07920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C7K38_RS07925	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C7K38_RS07930	COG0656	L-ascorbic acid biosynthetic process
C7K38_RS07945	COG4221	oxidoreductase activity
C7K38_RS07960	COG0667	Aldo Keto reductase
C7K38_RS07975	COG0789	Transcriptional regulator
C7K38_RS07980	COG0656	L-ascorbic acid biosynthetic process
C7K38_RS07990	COG3425	synthase
C7K38_RS08010	COG0741	lytic transglycosylase activity
C7K38_RS08020	COG0358	DNA primase activity
C7K38_RS08025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7K38_RS08040	COG2996	Protein conserved in bacteria
C7K38_RS08045	COG0735	belongs to the Fur family
C7K38_RS08055	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C7K38_RS08060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C7K38_RS08065	COG1187	pseudouridine synthase activity
C7K38_RS08070	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C7K38_RS08080	COG0514	ATP-dependent DNA helicase (RecQ)
C7K38_RS08090	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C7K38_RS08100	COG0539	negative regulation of cytoplasmic translation
C7K38_RS08105	COG1160	GTP binding
C7K38_RS08110	COG0776	regulation of translation
C7K38_RS08115	COG1028	Short-chain dehydrogenase reductase Sdr
C7K38_RS08130	COG5582	Belongs to the UPF0302 family
C7K38_RS08135	COG1694	Mazg nucleotide pyrophosphohydrolase
C7K38_RS08140	COG0617	tRNA 3'-terminal CCA addition
C7K38_RS08160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7K38_RS08165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7K38_RS08175	COG4483	Protein conserved in bacteria
C7K38_RS08180	COG1940	carbohydrate kinase activity
C7K38_RS08185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7K38_RS08195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C7K38_RS08200	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C7K38_RS08220	COG1214	PFAM Peptidase M22, glycoprotease
C7K38_RS08235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C7K38_RS08240	COG0052	Belongs to the universal ribosomal protein uS2 family
C7K38_RS08245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C7K38_RS08250	COG0528	UMP kinase activity
C7K38_RS08255	COG0233	cytoplasmic translational termination
C7K38_RS08260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C7K38_RS08265	COG4589	Belongs to the CDS family
C7K38_RS08270	COG0750	zinc metalloprotease
C7K38_RS08275	COG0442	prolyl-tRNA aminoacylation
C7K38_RS08285	COG2137	regulation of response to DNA damage stimulus
C7K38_RS08290	COG1194	a g-specific adenine glycosylase
C7K38_RS08295	COG3557	Belongs to the UPF0374 family
C7K38_RS08305	COG1253	flavin adenine dinucleotide binding
C7K38_RS08310	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C7K38_RS08320	COG0542	response to heat
C7K38_RS08330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS08335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7K38_RS08350	COG0438	transferase activity, transferring glycosyl groups
C7K38_RS08355	COG2084	Dehydrogenase
C7K38_RS08360	COG4703	Protein of unknown function (DUF1797)
C7K38_RS08370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7K38_RS08375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7K38_RS08380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C7K38_RS08385	COG1028	Short-chain dehydrogenase reductase Sdr
C7K38_RS08390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7K38_RS08395	COG0511	ligase activity, forming carbon-carbon bonds
C7K38_RS08400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7K38_RS08405	COG0439	Biotin carboxylase
C7K38_RS08410	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C7K38_RS08415	COG0825	malonyl-CoA metabolic process
C7K38_RS08430	COG1607	acyl-coa hydrolase
C7K38_RS08450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K38_RS08455	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C7K38_RS08475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS08475	COG1263	PTS System
C7K38_RS08535	COG2610	gluconate transmembrane transporter activity
C7K38_RS08540	COG1929	Belongs to the glycerate kinase type-1 family
C7K38_RS08545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K38_RS08565	COG4975	Glucose uptake
C7K38_RS08570	COG0673	inositol 2-dehydrogenase activity
C7K38_RS08575	COG1349	DNA-binding transcription factor activity
C7K38_RS08580	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C7K38_RS08585	COG0673	inositol 2-dehydrogenase activity
C7K38_RS08590	COG1063	alcohol dehydrogenase
C7K38_RS08605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS08605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS08605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS08610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS08610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS08610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS08615	COG3684	Belongs to the aldolase LacD family
C7K38_RS08645	COG1129	ABC transporter
C7K38_RS08665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K38_RS08670	COG0277	FAD linked oxidase domain protein
C7K38_RS08695	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C7K38_RS08700	COG0366	Alpha amylase catalytic
C7K38_RS08745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7K38_RS08765	COG0511	ligase activity, forming carbon-carbon bonds
C7K38_RS08770	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C7K38_RS08780	COG2723	6-phospho-beta-galactosidase activity
C7K38_RS08785	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C7K38_RS08795	COG1263	PTS System
C7K38_RS08795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C7K38_RS08800	COG1486	melibiose metabolic process
C7K38_RS08805	COG1737	Transcriptional regulator
C7K38_RS08825	COG0165	Argininosuccinate lyase
C7K38_RS08840	COG2096	Adenosyltransferase
C7K38_RS08855	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C7K38_RS08860	COG1534	Rna-binding protein
C7K38_RS08865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C7K38_RS08870	COG1713	HD superfamily hydrolase involved in NAD metabolism
C7K38_RS08875	COG0799	negative regulation of ribosome biogenesis
C7K38_RS08880	COG2226	methyltransferase
C7K38_RS08890	COG1323	Belongs to the UPF0348 family
C7K38_RS08895	COG0569	domain protein
C7K38_RS08895	COG0475	glutathione-regulated potassium exporter activity
C7K38_RS08905	COG3973	AAA domain
C7K38_RS08930	COG3189	MarR family transcriptional regulator
C7K38_RS08940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7K38_RS08945	COG0779	Required for maturation of 30S ribosomal subunits
C7K38_RS08950	COG0195	Participates in both transcription termination and antitermination
C7K38_RS08955	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C7K38_RS08970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C7K38_RS08975	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C7K38_RS08980	COG0196	riboflavin kinase activity
C7K38_RS09020	COG1126	abc transporter atp-binding protein
C7K38_RS09030	COG0556	nucleotide-excision repair
C7K38_RS09035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7K38_RS09040	COG0471	metal ion transport
C7K38_RS09045	COG1660	Displays ATPase and GTPase activities
C7K38_RS09050	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C7K38_RS09055	COG1481	regulation of sporulation
C7K38_RS09065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C7K38_RS09075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7K38_RS09095	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C7K38_RS09100	COG1074	ATP-dependent DNA helicase activity
C7K38_RS09105	COG1733	regulation of RNA biosynthetic process
C7K38_RS09110	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C7K38_RS09115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7K38_RS09115	COG0072	phenylalanine-tRNA ligase activity
C7K38_RS09120	COG0180	Tryptophanyl-tRNA synthetase
C7K38_RS09130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C7K38_RS09135	COG0765	amino acid transport
C7K38_RS09140	COG0765	amino acid transport
C7K38_RS09150	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C7K38_RS09155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C7K38_RS09170	COG0668	transmembrane transport
C7K38_RS09175	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C7K38_RS09180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7K38_RS09195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C7K38_RS09205	COG1234	tRNA 3'-trailer cleavage
C7K38_RS09210	COG0300	oxidoreductase activity
C7K38_RS09215	COG5416	Lipopolysaccharide assembly protein A domain
C7K38_RS09220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C7K38_RS09220	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C7K38_RS09225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7K38_RS09235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C7K38_RS09240	COG4224	UPF0291 protein
C7K38_RS09255	COG1388	LysM domain
C7K38_RS09255	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7K38_RS09260	COG0735	belongs to the Fur family
C7K38_RS09265	COG3935	DnaD domain protein
C7K38_RS09275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7K38_RS09280	COG3331	DNA recombination
C7K38_RS09285	COG4474	Belongs to the UPF0398 family
C7K38_RS09290	COG3599	regulation of cell shape
C7K38_RS09300	COG0116	Belongs to the methyltransferase superfamily
C7K38_RS09320	COG0667	Aldo Keto reductase
C7K38_RS09350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7K38_RS09360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C7K38_RS09365	COG2832	Protein of unknown function (DUF454)
C7K38_RS09375	COG1028	Short-chain dehydrogenase reductase Sdr
C7K38_RS09390	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C7K38_RS09395	COG1418	mRNA catabolic process
C7K38_RS09405	COG0513	Belongs to the DEAD box helicase family
C7K38_RS09410	COG2153	protein acetylation
C7K38_RS09425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C7K38_RS09435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C7K38_RS09440	COG0328	RNA-DNA hybrid ribonuclease activity
C7K38_RS09450	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C7K38_RS09460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C7K38_RS09465	COG0564	pseudouridine synthase activity
C7K38_RS09475	COG2233	PERMEase
C7K38_RS09480	COG0540	Belongs to the ATCase OTCase family
C7K38_RS09485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7K38_RS09490	COG0505	Belongs to the CarA family
C7K38_RS09495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C7K38_RS09500	COG0284	orotidine-5'-phosphate decarboxylase activity
C7K38_RS09515	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C7K38_RS09530	COG4120	Belongs to the binding-protein-dependent transport system permease family
C7K38_RS09540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7K38_RS09545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C7K38_RS09550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C7K38_RS09555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7K38_RS09560	COG0287	Prephenate dehydrogenase
C7K38_RS09570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C7K38_RS09575	COG0077	Prephenate dehydratase
C7K38_RS09585	COG1307	EDD domain protein, DegV family
C7K38_RS09590	COG2124	cytochrome p450
C7K38_RS09600	COG0454	-acetyltransferase
C7K38_RS09620	COG3859	Proton-coupled thiamine transporter YuaJ
C7K38_RS09630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7K38_RS09640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C7K38_RS09645	COG0753	catalase activity
C7K38_RS09660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C7K38_RS09675	COG1388	LysM domain
C7K38_RS09705	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7K38_RS09735	COG0167	dihydroorotate dehydrogenase activity
C7K38_RS09745	COG2207	Transcriptional regulator
C7K38_RS09745	COG3708	Transcriptional regulator
C7K38_RS09750	COG2151	metal-sulfur cluster biosynthetic enzyme
C7K38_RS09755	COG1199	ATP-dependent helicase activity
C7K38_RS09755	COG1199	ATP-dependent helicase activity
C7K38_RS09770	COG1968	undecaprenyl-diphosphatase activity
C7K38_RS09775	COG0268	Binds directly to 16S ribosomal RNA
C7K38_RS09780	COG1466	dna polymerase III delta subunit
C7K38_RS09785	COG2333	competence protein COMEC
C7K38_RS09785	COG0658	competence protein
C7K38_RS09790	COG2131	deaminase
C7K38_RS09795	COG1596	polysaccharide export
C7K38_RS09795	COG1555	photosystem II stabilization
C7K38_RS09800	COG0546	phosphoglycolate phosphatase activity
C7K38_RS09810	COG1126	abc transporter atp-binding protein
C7K38_RS09815	COG0765	amino acid transport
C7K38_RS09820	COG0519	Catalyzes the synthesis of GMP from XMP
C7K38_RS09830	COG0702	epimerase
C7K38_RS09840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C7K38_RS09850	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7K38_RS09855	COG0154	amidase activity
C7K38_RS09860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7K38_RS09865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C7K38_RS09870	COG0210	DNA helicase
C7K38_RS09875	COG0038	chloride channel
C7K38_RS09880	COG1349	DNA-binding transcription factor activity
C7K38_RS09885	COG1105	Belongs to the carbohydrate kinase PfkB family
C7K38_RS09890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS09890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C7K38_RS09890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7K38_RS09895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C7K38_RS09900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7K38_RS09905	COG0544	peptidyl-prolyl cis-trans isomerase activity
C7K38_RS09915	COG1714	RDD family
C7K38_RS09935	COG2365	Tyrosine phosphatase family
C7K38_RS09945	COG0402	S-adenosylhomocysteine deaminase activity
C7K38_RS09950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C7K38_RS09955	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C7K38_RS09970	COG0481	GTPase activity
C7K38_RS09980	COG0628	permease
C7K38_RS09985	COG0542	response to heat
C7K38_RS09995	COG2195	Cleaves the N-terminal amino acid of tripeptides
C7K38_RS10000	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C7K38_RS10005	COG2384	SAM-dependent methyltransferase
C7K38_RS10010	COG1484	DNA-dependent DNA replication
C7K38_RS10020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C7K38_RS10025	COG0237	dephospho-CoA kinase activity
C7K38_RS10030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7K38_RS10035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K38_RS10035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C7K38_RS10055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7K38_RS10060	COG3091	SprT-like family
C7K38_RS10065	COG2183	response to ionizing radiation
C7K38_RS10090	COG3480	Lon protease (S16) C-terminal proteolytic domain
C7K38_RS10095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C7K38_RS10100	COG0742	ribosomal rna small subunit methyltransferase
C7K38_RS10105	COG4471	UPF0298 protein
C7K38_RS10115	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C7K38_RS10120	COG0772	Belongs to the SEDS family
C7K38_RS10125	COG4838	Belongs to the UPF0358 family
C7K38_RS10130	COG1217	gtp-binding protein TYPA
C7K38_RS10135	COG0483	inositol monophosphate 1-phosphatase activity
C7K38_RS10140	COG4476	Belongs to the UPF0223 family
C7K38_RS10150	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7K38_RS10165	COG0561	phosphatase activity
C7K38_RS10185	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C7K38_RS10190	COG0516	GMP reductase activity
C7K38_RS10195	COG4989	oxidoreductase activity
C7K38_RS10200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C7K38_RS10205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C7K38_RS10210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7K38_RS10215	COG1966	Carbon starvation protein
C7K38_RS10220	COG3279	Response regulator of the LytR AlgR family
C7K38_RS10225	COG3275	phosphorelay sensor kinase activity
C7K38_RS10235	COG1705	Flagellar rod assembly protein muramidase FlgJ
C7K38_RS10240	COG1876	peptidase activity
C7K38_RS10270	COG0436	Aminotransferase
C7K38_RS10285	COG0667	Aldo Keto reductase
C7K38_RS10290	COG3103	Sh3 type 3 domain protein
C7K38_RS10290	COG0366	Alpha amylase catalytic
C7K38_RS10295	COG0058	SHG alpha-glucan phosphorylase activity
C7K38_RS10305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7K38_RS10310	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7K38_RS10320	COG1227	inorganic diphosphatase activity
C7K38_RS10325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C7K38_RS10335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C7K38_RS10340	COG0187	DNA topoisomerase II activity
C7K38_RS10345	COG1832	CoA-binding protein
C7K38_RS10350	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C7K38_RS10365	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C7K38_RS10370	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C7K38_RS10380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C7K38_RS10385	COG0758	DNA mediated transformation
C7K38_RS10390	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7K38_RS10400	COG0681	Belongs to the peptidase S26 family
C7K38_RS10405	COG3409	Peptidoglycan-binding domain 1 protein
C7K38_RS10405	COG0793	Belongs to the peptidase S41A family
C7K38_RS10410	COG4479	Belongs to the UPF0346 family
C7K38_RS10420	COG4698	Protein conserved in bacteria
C7K38_RS10425	COG2755	lipolytic protein G-D-S-L family
C7K38_RS10430	COG1307	EDD domain protein, DegV family
C7K38_RS10435	COG0371	Dehydrogenase
C7K38_RS10440	COG1272	protein, Hemolysin III
C7K38_RS10455	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C7K38_RS10460	COG0488	(ABC) transporter
C7K38_RS10465	COG0768	penicillin binding
C7K38_RS10480	COG1316	TRANSCRIPTIONal
C7K38_RS10485	COG1682	transport, permease protein
C7K38_RS10490	COG1134	teichoic acid transport
C7K38_RS10495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C7K38_RS10510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C7K38_RS10520	COG2246	polysaccharide biosynthetic process
C7K38_RS10535	COG0463	Glycosyl transferase, family 2
C7K38_RS10540	COG1368	sulfuric ester hydrolase activity
C7K38_RS10545	COG4841	protein insertion into membrane
C7K38_RS10550	COG0569	domain protein
C7K38_RS10555	COG2197	response regulator
C7K38_RS10560	COG4585	Histidine kinase
C7K38_RS10570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7K38_RS10575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C7K38_RS10595	COG2826	transposase and inactivated derivatives, IS30 family
C7K38_RS10600	COG0463	Glycosyl transferase, family 2
C7K38_RS10600	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7K38_RS10605	COG0584	glycerophosphoryl diester phosphodiesterase
C7K38_RS10610	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C7K38_RS10630	COG0017	Asparaginyl-tRNA synthetase
C7K38_RS10635	COG0436	Aminotransferase
C7K38_RS10645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7K38_RS10645	COG1199	ATP-dependent helicase activity
C7K38_RS10650	COG1278	Cold shock
C7K38_RS10660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C7K38_RS10665	COG2217	Heavy metal translocating P-type atpase
C7K38_RS10685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C7K38_RS10740	COG2176	DNA-directed DNA polymerase activity
C7K38_RS10745	COG1518	maintenance of DNA repeat elements
C7K38_RS10760	COG1857	crispr-associated protein
C7K38_RS10825	COG1447	Phosphotransferase system cellobiose-specific component IIA
C7K38_RS10840	COG0513	Belongs to the DEAD box helicase family
C7K38_RS10845	COG0673	inositol 2-dehydrogenase activity
C7K38_RS10855	COG1686	Belongs to the peptidase S11 family
C7K38_RS10885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7K38_RS10895	COG1254	Belongs to the acylphosphatase family
C7K38_RS10910	COG0751	glycine-tRNA ligase activity
C7K38_RS10915	COG0752	glycyl-tRNA synthetase alpha subunit
C7K38_RS10920	COG1381	Involved in DNA repair and RecF pathway recombination
C7K38_RS10925	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C7K38_RS10935	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C7K38_RS10945	COG1702	phosphate starvation-inducible protein PhoH
C7K38_RS10950	COG1610	YqeY-like protein
C7K38_RS10955	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C7K38_RS10965	COG0735	belongs to the Fur family
C7K38_RS10970	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C7K38_RS10975	COG0083	homoserine kinase activity
C7K38_RS10980	COG0460	homoserine dehydrogenase
C7K38_RS10985	COG0640	Transcriptional regulator
C7K38_RS10990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7K38_RS10995	COG2723	6-phospho-beta-galactosidase activity
C7K38_RS11000	COG0561	phosphatase activity
C7K38_RS11010	COG1737	Transcriptional regulator
C7K38_RS11015	COG3344	reverse transcriptase
C7K38_RS11020	COG3763	UPF0154 protein
C7K38_RS11025	COG0656	L-ascorbic acid biosynthetic process
C7K38_RS11030	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C7K38_RS11040	COG3344	reverse transcriptase
C7K38_RS11045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7K38_RS11050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C7K38_RS11080	COG0367	asparagine synthase
C7K38_RS11090	COG3328	transposase activity
C7K38_RS11095	COG3344	reverse transcriptase
C7K38_RS11100	COG1609	Transcriptional regulator
C7K38_RS11125	COG0783	Belongs to the Dps family
C7K38_RS11130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K38_RS11180	COG0783	Belongs to the Dps family
C7K38_RS11200	COG2217	Heavy metal translocating P-type atpase
C7K38_RS11210	COG0582	viral genome integration into host DNA
C7K38_RS11255	COG3385	transposase activity
C7K38_RS11285	COG1131	(ABC) transporter
C7K38_RS11290	COG1131	(ABC) transporter
C7K38_RS11305	COG2217	Heavy metal translocating P-type atpase
C7K38_RS11325	COG0783	Belongs to the Dps family
C7K38_RS11375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7K38_RS11380	COG0783	Belongs to the Dps family
C7K38_RS11395	COG0783	Belongs to the Dps family
C7K38_RS11405	COG1131	(ABC) transporter
C7K38_RS11410	COG1131	(ABC) transporter
C7K38_RS11440	COG3385	transposase activity