locus-tag	class	description
GKE56_RS00010	COG0739	heme binding
GKE56_RS00020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKE56_RS00040	COG0045	succinate-CoA ligase (ADP-forming) activity
GKE56_RS00085	COG0549	Belongs to the carbamate kinase family
GKE56_RS00120	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
GKE56_RS00130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GKE56_RS00155	COG2233	PERMEase
GKE56_RS00170	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GKE56_RS00175	COG1304	FMN binding
GKE56_RS00180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GKE56_RS00190	COG0039	L-malate dehydrogenase activity
GKE56_RS00205	COG2838	Isocitrate dehydrogenase
GKE56_RS00225	COG0489	protein tyrosine kinase activity
GKE56_RS00235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GKE56_RS00245	COG1349	DNA-binding transcription factor activity
GKE56_RS00250	COG0180	Tryptophanyl-tRNA synthetase
GKE56_RS00265	COG1686	Belongs to the peptidase S11 family
GKE56_RS00270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GKE56_RS00285	COG2009	succinate dehydrogenase
GKE56_RS00290	COG0438	transferase activity, transferring glycosyl groups
GKE56_RS00300	COG3559	Exporter of polyketide antibiotics
GKE56_RS00315	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKE56_RS00315	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKE56_RS00320	COG1473	amidohydrolase
GKE56_RS00320	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GKE56_RS00325	COG1744	ABC transporter substrate-binding protein PnrA-like
GKE56_RS00330	COG3845	ABC transporter
GKE56_RS00360	COG0745	RESPONSE REGULATOR receiver
GKE56_RS00365	COG5002	protein histidine kinase activity
GKE56_RS00375	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GKE56_RS00395	COG0714	Associated with various cellular activities
GKE56_RS00430	COG1012	belongs to the aldehyde dehydrogenase family
GKE56_RS00440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKE56_RS00450	COG3842	ATPase activity
GKE56_RS00480	COG4770	biotin carboxylase activity
GKE56_RS00485	COG3483	tryptophan 2,3-dioxygenase activity
GKE56_RS00490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GKE56_RS00515	COG1960	acyl-CoA dehydrogenase activity
GKE56_RS00520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GKE56_RS00525	COG0424	maF-like protein
GKE56_RS00550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GKE56_RS00565	COG1024	Enoyl-CoA hydratase
GKE56_RS00570	COG0745	RESPONSE REGULATOR receiver
GKE56_RS00575	COG2205	protein histidine kinase activity
GKE56_RS00590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GKE56_RS00595	COG1832	CoA-binding protein
GKE56_RS00600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKE56_RS00605	COG1083	cytidylyl-transferase
GKE56_RS00615	COG2089	acid synthase
GKE56_RS00620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GKE56_RS00625	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GKE56_RS00630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKE56_RS00635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GKE56_RS00660	COG1216	Glycosyl transferase, family 2
GKE56_RS00665	COG1216	Glycosyl transferase, family 2
GKE56_RS00675	COG1316	TRANSCRIPTIONal
GKE56_RS00685	COG1215	transferase activity, transferring glycosyl groups
GKE56_RS00710	COG1216	Glycosyl transferase, family 2
GKE56_RS00745	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GKE56_RS00785	COG0463	Glycosyl transferase, family 2
GKE56_RS00800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GKE56_RS00815	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GKE56_RS00845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKE56_RS00875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GKE56_RS00885	COG1051	belongs to the nudix hydrolase family
GKE56_RS00890	COG0745	RESPONSE REGULATOR receiver
GKE56_RS00895	COG5002	protein histidine kinase activity
GKE56_RS00965	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GKE56_RS00975	COG2304	oxidoreductase activity
GKE56_RS00995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GKE56_RS01000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GKE56_RS01005	COG2197	response regulator
GKE56_RS01010	COG3214	Protein conserved in bacteria
GKE56_RS01200	COG1072	(Pantothenic acid kinase))
GKE56_RS01210	COG1012	belongs to the aldehyde dehydrogenase family
GKE56_RS01220	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GKE56_RS01225	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GKE56_RS01315	COG0183	Belongs to the thiolase family
GKE56_RS01320	COG1703	isobutyryl-CoA mutase activity
GKE56_RS01325	COG0515	serine threonine protein kinase
GKE56_RS01325	COG2815	serine threonine protein kinase
GKE56_RS01355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKE56_RS01355	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKE56_RS01380	COG1181	Belongs to the D-alanine--D-alanine ligase family
GKE56_RS01400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GKE56_RS01410	COG0366	Alpha amylase catalytic
GKE56_RS01415	COG0366	Alpha amylase catalytic
GKE56_RS01445	COG2226	methyltransferase
GKE56_RS01450	COG0110	maltose O-acetyltransferase activity
GKE56_RS01460	COG2086	electron transfer activity
GKE56_RS01465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GKE56_RS01490	COG0318	PFAM AMP-dependent synthetase and ligase
GKE56_RS01495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GKE56_RS01500	COG2186	Transcriptional regulator
GKE56_RS01505	COG3265	gluconokinase activity
GKE56_RS01515	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GKE56_RS01520	COG2884	Cell division ATP-binding protein ftsE
GKE56_RS01530	COG0739	heme binding
GKE56_RS01530	COG0741	lytic transglycosylase activity
GKE56_RS01530	COG1196	nuclear chromosome segregation
GKE56_RS01535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GKE56_RS01550	COG3237	CsbD-like
GKE56_RS01555	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GKE56_RS01560	COG2910	NAD(P)H-binding
GKE56_RS01565	COG1733	regulation of RNA biosynthetic process
GKE56_RS01615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GKE56_RS01625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKE56_RS01635	COG0513	Belongs to the DEAD box helicase family
GKE56_RS01640	COG1678	Uncharacterized ACR, COG1678
GKE56_RS01670	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GKE56_RS01695	COG0737	Belongs to the 5'-nucleotidase family
GKE56_RS01705	COG2146	nitrite reductase [NAD(P)H] activity
GKE56_RS01705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GKE56_RS01710	COG2146	nitrite reductase [NAD(P)H] activity
GKE56_RS01710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GKE56_RS01715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GKE56_RS01720	COG0243	molybdopterin cofactor binding
GKE56_RS01725	COG2223	nitrite transmembrane transporter activity
GKE56_RS01730	COG1335	isochorismatase
GKE56_RS01745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GKE56_RS01755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GKE56_RS01760	COG1234	tRNA 3'-trailer cleavage
GKE56_RS01765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKE56_RS01775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GKE56_RS01780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GKE56_RS01805	COG1122	ATPase activity
GKE56_RS01815	COG0310	cobalt ion transport
GKE56_RS01860	COG4941	Belongs to the sigma-70 factor family
GKE56_RS01915	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GKE56_RS01960	COG0629	single-stranded DNA binding
GKE56_RS01985	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS02000	COG0640	Transcriptional regulator
GKE56_RS02035	COG1946	Acyl-CoA thioesterase
GKE56_RS02040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GKE56_RS02045	COG2364	Membrane
GKE56_RS02055	COG0431	NADPH-dependent FMN reductase
GKE56_RS02060	COG0514	ATP-dependent DNA helicase (RecQ)
GKE56_RS02085	COG0366	Alpha amylase catalytic
GKE56_RS02095	COG0668	transmembrane transport
GKE56_RS02105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GKE56_RS02110	COG0698	ribose 5-phosphate isomerase
GKE56_RS02150	COG0544	peptidyl-prolyl cis-trans isomerase activity
GKE56_RS02160	COG1609	Transcriptional regulator
GKE56_RS02170	COG0740	serine-type endopeptidase activity
GKE56_RS02175	COG0740	serine-type endopeptidase activity
GKE56_RS02180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GKE56_RS02195	COG0714	Associated with various cellular activities
GKE56_RS02230	COG0204	Acyl-transferase
GKE56_RS02240	COG0277	FAD linked oxidase domain protein
GKE56_RS02250	COG0285	dihydrofolate synthase activity
GKE56_RS02260	COG0105	UTP biosynthetic process
GKE56_RS02265	COG1846	Transcriptional regulator
GKE56_RS02285	COG0768	penicillin binding
GKE56_RS02305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GKE56_RS02310	COG1185	polyribonucleotide nucleotidyltransferase activity
GKE56_RS02315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GKE56_RS02320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GKE56_RS02350	COG3460	Phenylacetate-CoA oxygenase
GKE56_RS02360	COG2151	metal-sulfur cluster biosynthetic enzyme
GKE56_RS02375	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GKE56_RS02380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GKE56_RS02385	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GKE56_RS02390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GKE56_RS02400	COG2814	Major facilitator Superfamily
GKE56_RS02415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GKE56_RS02425	COG1058	Belongs to the CinA family
GKE56_RS02425	COG1546	Belongs to the CinA family
GKE56_RS02430	COG1396	sequence-specific DNA binding
GKE56_RS02435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GKE56_RS02450	COG2070	2-Nitropropane dioxygenase
GKE56_RS02455	COG1131	(ABC) transporter
GKE56_RS02470	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GKE56_RS02475	COG2137	regulation of response to DNA damage stimulus
GKE56_RS02480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GKE56_RS02485	COG0242	peptide deformylase activity
GKE56_RS02490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GKE56_RS02495	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GKE56_RS02500	COG0405	Gamma-glutamyltransferase
GKE56_RS02510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GKE56_RS02515	COG0454	-acetyltransferase
GKE56_RS02540	COG0268	Binds directly to 16S ribosomal RNA
GKE56_RS02550	COG2814	Major facilitator Superfamily
GKE56_RS02555	COG0481	GTPase activity
GKE56_RS02565	COG1051	belongs to the nudix hydrolase family
GKE56_RS02570	COG2365	Tyrosine phosphatase family
GKE56_RS02590	COG1420	regulation of RNA biosynthetic process
GKE56_RS02595	COG0484	heat shock protein binding
GKE56_RS02610	COG1595	DNA-templated transcription, initiation
GKE56_RS02615	COG0537	adenosine 5'-monophosphoramidase activity
GKE56_RS02625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GKE56_RS02635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GKE56_RS02650	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GKE56_RS02655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GKE56_RS02660	COG0183	Belongs to the thiolase family
GKE56_RS02670	COG1381	Involved in DNA repair and RecF pathway recombination
GKE56_RS02675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GKE56_RS02685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GKE56_RS02690	COG1131	(ABC) transporter
GKE56_RS02705	COG0423	glycine-tRNA ligase activity
GKE56_RS02720	COG1131	(ABC) transporter
GKE56_RS02725	COG0842	Transport permease protein
GKE56_RS02730	COG4585	Histidine kinase
GKE56_RS02735	COG2197	response regulator
GKE56_RS02755	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GKE56_RS02760	COG3842	ATPase activity
GKE56_RS02775	COG0358	DNA primase activity
GKE56_RS02790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GKE56_RS02795	COG1126	abc transporter atp-binding protein
GKE56_RS02855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GKE56_RS02860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GKE56_RS02880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GKE56_RS02885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GKE56_RS02915	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GKE56_RS02945	COG3022	response to hydroperoxide
GKE56_RS02950	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GKE56_RS03015	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GKE56_RS03030	COG1940	carbohydrate kinase activity
GKE56_RS03050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKE56_RS03055	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GKE56_RS03085	COG0174	glutamine synthetase
GKE56_RS03090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GKE56_RS03095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GKE56_RS03100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GKE56_RS03105	COG0131	Imidazoleglycerol-phosphate dehydratase
GKE56_RS03115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GKE56_RS03120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GKE56_RS03140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GKE56_RS03145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GKE56_RS03150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GKE56_RS03155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKE56_RS03160	COG5002	protein histidine kinase activity
GKE56_RS03170	COG0072	phenylalanine-tRNA ligase activity
GKE56_RS03170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GKE56_RS03175	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS03180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GKE56_RS03190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GKE56_RS03195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GKE56_RS03200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GKE56_RS03205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GKE56_RS03210	COG1438	arginine binding
GKE56_RS03215	COG0165	Argininosuccinate lyase
GKE56_RS03240	COG2094	Belongs to the DNA glycosylase MPG family
GKE56_RS03245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GKE56_RS03270	COG0647	UMP catabolic process
GKE56_RS03290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GKE56_RS03295	COG0497	DNA recombination
GKE56_RS03330	COG0504	CTP synthase activity
GKE56_RS03345	COG3012	SEC-C Motif Domain Protein
GKE56_RS03350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GKE56_RS03360	COG2267	carboxylic ester hydrolase activity
GKE56_RS03390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GKE56_RS03395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GKE56_RS03400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GKE56_RS03405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GKE56_RS03415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GKE56_RS03420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GKE56_RS03425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GKE56_RS03430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GKE56_RS03435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GKE56_RS03440	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GKE56_RS03450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GKE56_RS03460	COG0505	Belongs to the CarA family
GKE56_RS03465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GKE56_RS03470	COG0543	2 iron, 2 sulfur cluster binding
GKE56_RS03475	COG0167	dihydroorotate dehydrogenase activity
GKE56_RS03480	COG0284	orotidine-5'-phosphate decarboxylase activity
GKE56_RS03490	COG0194	GDP metabolic process
GKE56_RS03495	COG1758	RNA polymerase activity
GKE56_RS03505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GKE56_RS03515	COG0242	peptide deformylase activity
GKE56_RS03540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GKE56_RS03555	COG3201	nicotinamide mononucleotide transporter
GKE56_RS03560	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GKE56_RS03560	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GKE56_RS03565	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GKE56_RS03570	COG0140	phosphoribosyl-ATP diphosphatase activity
GKE56_RS03575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GKE56_RS03590	COG4129	membrane
GKE56_RS03595	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GKE56_RS03600	COG0107	imidazoleglycerol-phosphate synthase activity
GKE56_RS03615	COG1132	(ABC) transporter
GKE56_RS03620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GKE56_RS03640	COG0134	indole-3-glycerol-phosphate synthase activity
GKE56_RS03645	COG0133	tryptophan synthase activity
GKE56_RS03650	COG0159	tryptophan synthase activity
GKE56_RS03690	COG0789	Transcriptional regulator
GKE56_RS03695	COG0071	Belongs to the small heat shock protein (HSP20) family
GKE56_RS03700	COG0395	ABC-type sugar transport system, permease component
GKE56_RS03750	COG0515	serine threonine protein kinase
GKE56_RS03750	COG2815	serine threonine protein kinase
GKE56_RS03810	COG0596	Alpha beta hydrolase
GKE56_RS03840	COG5002	protein histidine kinase activity
GKE56_RS03840	COG0784	Response regulator, receiver
GKE56_RS03840	COG2205	protein histidine kinase activity
GKE56_RS03850	COG4999	Histidine kinase
GKE56_RS03850	COG2205	protein histidine kinase activity
GKE56_RS03850	COG3437	response regulator, receiver
GKE56_RS03850	COG3850	Histidine kinase
GKE56_RS03870	COG2050	protein possibly involved in aromatic compounds catabolism
GKE56_RS03895	COG2271	Major facilitator Superfamily
GKE56_RS03900	COG2226	methyltransferase
GKE56_RS03905	COG0539	negative regulation of cytoplasmic translation
GKE56_RS03910	COG3467	pyridoxamine 5'-phosphate
GKE56_RS03915	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GKE56_RS03915	COG0237	dephospho-CoA kinase activity
GKE56_RS03920	COG2149	membrane
GKE56_RS03930	COG0556	nucleotide-excision repair
GKE56_RS03975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GKE56_RS04015	COG1660	Displays ATPase and GTPase activities
GKE56_RS04025	COG1481	regulation of sporulation
GKE56_RS04035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GKE56_RS04040	COG0126	phosphoglycerate kinase activity
GKE56_RS04045	COG0149	triose-phosphate isomerase activity
GKE56_RS04050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GKE56_RS04060	COG0363	glucosamine-6-phosphate deaminase activity
GKE56_RS04075	COG0166	Belongs to the GPI family
GKE56_RS04080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GKE56_RS04090	COG0109	protoheme IX farnesyltransferase activity
GKE56_RS04120	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GKE56_RS04120	COG1672	PFAM Archaeal ATPase
GKE56_RS04125	COG2197	response regulator
GKE56_RS04150	COG0396	ATPase activity
GKE56_RS04160	COG0822	iron-sulfur transferase activity
GKE56_RS04165	COG2151	metal-sulfur cluster biosynthetic enzyme
GKE56_RS04195	COG0175	sulfate reduction
GKE56_RS04210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GKE56_RS04210	COG1648	precorrin-2 dehydrogenase activity
GKE56_RS04235	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GKE56_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS04260	COG0189	ligase activity
GKE56_RS04260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GKE56_RS04270	COG4242	Belongs to the peptidase S51 family
GKE56_RS04275	COG3830	Belongs to the UPF0237 family
GKE56_RS04275	COG0560	Phosphoserine phosphatase
GKE56_RS04300	COG0297	glycogen (starch) synthase activity
GKE56_RS04310	COG1119	ATPase activity
GKE56_RS04355	COG2814	Major facilitator Superfamily
GKE56_RS04370	COG1793	dna ligase
GKE56_RS04375	COG0686	Belongs to the AlaDH PNT family
GKE56_RS04385	COG0726	polysaccharide deacetylase
GKE56_RS04395	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GKE56_RS04400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKE56_RS04400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKE56_RS04415	COG0438	transferase activity, transferring glycosyl groups
GKE56_RS04425	COG1063	alcohol dehydrogenase
GKE56_RS04515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKE56_RS04520	COG5002	protein histidine kinase activity
GKE56_RS04535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKE56_RS04560	COG0667	Aldo Keto reductase
GKE56_RS04565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKE56_RS04570	COG1968	undecaprenyl-diphosphatase activity
GKE56_RS04590	COG0215	cysteine-tRNA ligase activity
GKE56_RS04600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GKE56_RS04610	COG1410	methionine synthase
GKE56_RS04610	COG0646	methionine synthase
GKE56_RS04615	COG0517	IMP dehydrogenase activity
GKE56_RS04615	COG1994	Peptidase M50
GKE56_RS04625	COG1222	aaa ATPase
GKE56_RS04640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GKE56_RS04660	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GKE56_RS04665	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GKE56_RS04670	COG0450	alkyl hydroperoxide reductase
GKE56_RS04690	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GKE56_RS04745	COG2318	DinB family
GKE56_RS04750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GKE56_RS04755	COG1522	sequence-specific DNA binding
GKE56_RS04760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GKE56_RS04770	COG1509	lysine 2,3-aminomutase activity
GKE56_RS04775	COG0604	alcohol dehydrogenase
GKE56_RS04785	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GKE56_RS04790	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKE56_RS04795	COG1607	acyl-coa hydrolase
GKE56_RS04805	COG1216	Glycosyl transferase, family 2
GKE56_RS04865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GKE56_RS04885	COG3422	double-strand break repair
GKE56_RS04900	COG0531	amino acid
GKE56_RS04915	COG0009	L-threonylcarbamoyladenylate synthase
GKE56_RS04920	COG1063	alcohol dehydrogenase
GKE56_RS04935	COG1765	OsmC-like protein
GKE56_RS04950	COG0406	alpha-ribazole phosphatase activity
GKE56_RS04970	COG0420	3'-5' exonuclease activity
GKE56_RS04975	COG0419	ATPase involved in DNA repair
GKE56_RS04980	COG0419	ATPase involved in DNA repair
GKE56_RS04985	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GKE56_RS04985	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GKE56_RS05080	COG1160	GTP binding
GKE56_RS05090	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GKE56_RS05105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GKE56_RS05135	COG0124	histidyl-tRNA synthetase
GKE56_RS05145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GKE56_RS05155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GKE56_RS05160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GKE56_RS05165	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GKE56_RS05180	COG2255	four-way junction helicase activity
GKE56_RS05185	COG0632	four-way junction helicase activity
GKE56_RS05190	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GKE56_RS05195	COG0217	transcriptional regulatory protein
GKE56_RS05200	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GKE56_RS05210	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GKE56_RS05220	COG0438	transferase activity, transferring glycosyl groups
GKE56_RS05225	COG1560	Kdo2-lipid A biosynthetic process
GKE56_RS05240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GKE56_RS05255	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS05260	COG0183	Belongs to the thiolase family
GKE56_RS05275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GKE56_RS05315	COG0512	Glutamine amidotransferase of anthranilate synthase
GKE56_RS05315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GKE56_RS05325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKE56_RS05340	COG3152	Membrane
GKE56_RS05365	COG2197	response regulator
GKE56_RS05410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GKE56_RS05455	COG3665	Urea carboxylase-associated protein
GKE56_RS05465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GKE56_RS05470	COG0366	Alpha amylase catalytic
GKE56_RS05495	COG0745	RESPONSE REGULATOR receiver
GKE56_RS05505	COG2205	protein histidine kinase activity
GKE56_RS05510	COG0745	RESPONSE REGULATOR receiver
GKE56_RS05515	COG0671	phosphoesterase, PA-phosphatase related
GKE56_RS05525	COG1960	acyl-CoA dehydrogenase activity
GKE56_RS05545	COG5002	protein histidine kinase activity
GKE56_RS05560	COG3250	beta-galactosidase activity
GKE56_RS05565	COG0395	ABC-type sugar transport system, permease component
GKE56_RS05570	COG1175	transmembrane transport
GKE56_RS05585	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS05585	COG3347	Dehydrogenase
GKE56_RS05590	COG1070	Carbohydrate kinase
GKE56_RS05595	COG1609	Transcriptional regulator
GKE56_RS05600	COG0247	lactate metabolic process
GKE56_RS05605	COG1139	Iron-sulfur cluster binding protein
GKE56_RS05610	COG1556	Lactate utilization protein
GKE56_RS05620	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GKE56_RS05630	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GKE56_RS05645	COG3485	protocatechuate 3,4-dioxygenase
GKE56_RS05650	COG3485	protocatechuate 3,4-dioxygenase
GKE56_RS05655	COG1414	Transcriptional regulator
GKE56_RS05665	COG1228	amidohydrolase
GKE56_RS05675	COG0179	Fumarylacetoacetate (FAA) hydrolase
GKE56_RS05685	COG1414	Transcriptional regulator
GKE56_RS05705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GKE56_RS05715	COG4214	carbohydrate transport
GKE56_RS05725	COG3250	beta-galactosidase activity
GKE56_RS05740	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GKE56_RS05755	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS05765	COG2723	6-phospho-beta-galactosidase activity
GKE56_RS05770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GKE56_RS05780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GKE56_RS05785	COG0156	8-amino-7-oxononanoate synthase activity
GKE56_RS05790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GKE56_RS05835	COG1335	isochorismatase
GKE56_RS05850	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS05890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GKE56_RS05895	COG4941	Belongs to the sigma-70 factor family
GKE56_RS05930	COG0789	Transcriptional regulator
GKE56_RS05945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GKE56_RS05960	COG2226	methyltransferase
GKE56_RS05990	COG1960	acyl-CoA dehydrogenase activity
GKE56_RS05995	COG2326	polyphosphate kinase activity
GKE56_RS06015	COG1793	dna ligase
GKE56_RS06020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GKE56_RS06030	COG3253	May function as heme-dependent peroxidase
GKE56_RS06035	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GKE56_RS06045	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GKE56_RS06065	COG0183	Belongs to the thiolase family
GKE56_RS06075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GKE56_RS06100	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GKE56_RS06110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GKE56_RS06115	COG0531	amino acid
GKE56_RS06120	COG0569	domain protein
GKE56_RS06145	COG0756	dUTP diphosphatase activity
GKE56_RS06165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GKE56_RS06170	COG2860	membrane
GKE56_RS06180	COG1435	thymidine kinase activity
GKE56_RS06200	COG0778	Nitroreductase
GKE56_RS06205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GKE56_RS06215	COG1653	transport
GKE56_RS06240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GKE56_RS06245	COG0187	DNA topoisomerase II activity
GKE56_RS06265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GKE56_RS06270	COG2264	protein methyltransferase activity
GKE56_RS06320	COG0142	geranyltranstransferase activity
GKE56_RS06330	COG3942	CHAP domain
GKE56_RS06330	COG1388	LysM domain
GKE56_RS06335	COG0515	serine threonine protein kinase
GKE56_RS06335	COG2815	serine threonine protein kinase
GKE56_RS06340	COG0515	serine threonine protein kinase
GKE56_RS06340	COG2815	serine threonine protein kinase
GKE56_RS06355	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GKE56_RS06380	COG1940	carbohydrate kinase activity
GKE56_RS06385	COG1940	carbohydrate kinase activity
GKE56_RS06395	COG0003	Pfam Anion-transporting ATPase
GKE56_RS06445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GKE56_RS06455	COG1845	cytochrome c oxidase, subunit III
GKE56_RS06465	COG0723	plastoquinol--plastocyanin reductase activity
GKE56_RS06470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GKE56_RS06480	COG1376	ErfK ybiS ycfS ynhG family protein
GKE56_RS06505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GKE56_RS06510	COG1104	cysteine desulfurase activity
GKE56_RS06515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GKE56_RS06515	COG0425	Belongs to the sulfur carrier protein TusA family
GKE56_RS06520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GKE56_RS06525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKE56_RS06560	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GKE56_RS06565	COG3268	Saccharopine dehydrogenase
GKE56_RS06595	COG3845	ABC transporter
GKE56_RS06615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GKE56_RS06620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GKE56_RS06635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GKE56_RS06645	COG1090	epimerase
GKE56_RS06650	COG0515	serine threonine protein kinase
GKE56_RS06650	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GKE56_RS06660	COG0321	lipoyl(octanoyl) transferase activity
GKE56_RS06665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GKE56_RS06690	COG0174	glutamine synthetase
GKE56_RS06700	COG3158	transport of potassium into the cell
GKE56_RS06705	COG1278	Cold shock
GKE56_RS06720	COG2208	phosphoserine phosphatase activity
GKE56_RS06720	COG2172	sigma factor antagonist activity
GKE56_RS06720	COG1366	Belongs to the anti-sigma-factor antagonist family
GKE56_RS06735	COG0587	DNA-directed DNA polymerase activity
GKE56_RS06750	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GKE56_RS06775	COG1496	oxidoreductase activity
GKE56_RS06780	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GKE56_RS06790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GKE56_RS06795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GKE56_RS06805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GKE56_RS06810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GKE56_RS06820	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GKE56_RS06825	COG0768	penicillin binding
GKE56_RS06835	COG0275	rRNA processing
GKE56_RS06840	COG2001	Belongs to the MraZ family
GKE56_RS06845	COG0714	Associated with various cellular activities
GKE56_RS06855	COG1305	Transglutaminase-like
GKE56_RS06870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GKE56_RS06875	COG0589	response to stress
GKE56_RS06880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKE56_RS06965	COG2409	Drug exporters of the RND superfamily
GKE56_RS07020	COG0583	DNA-binding transcription factor activity
GKE56_RS07040	COG0154	amidase activity
GKE56_RS07045	COG1193	negative regulation of DNA recombination
GKE56_RS07055	COG0667	Aldo Keto reductase
GKE56_RS07070	COG2409	Drug exporters of the RND superfamily
GKE56_RS07095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GKE56_RS07100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GKE56_RS07125	COG0437	4 iron, 4 sulfur cluster binding
GKE56_RS07140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GKE56_RS07150	COG1247	-acetyltransferase
GKE56_RS07160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GKE56_RS07190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKE56_RS07200	COG2183	response to ionizing radiation
GKE56_RS07205	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GKE56_RS07210	COG1307	EDD domain protein, DegV family
GKE56_RS07215	COG0495	leucyl-tRNA aminoacylation
GKE56_RS07260	COG0823	Involved in the tonB-independent uptake of proteins
GKE56_RS07260	COG1506	peptidase
GKE56_RS07280	COG0179	Fumarylacetoacetate (FAA) hydrolase
GKE56_RS07290	COG0179	Fumarylacetoacetate (FAA) hydrolase
GKE56_RS07295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GKE56_RS07305	COG1175	transmembrane transport
GKE56_RS07345	COG1082	Xylose isomerase domain protein TIM barrel
GKE56_RS07355	COG3622	Belongs to the hyi family
GKE56_RS07380	COG0673	inositol 2-dehydrogenase activity
GKE56_RS07410	COG0477	Major facilitator Superfamily
GKE56_RS07420	COG1070	Carbohydrate kinase
GKE56_RS07425	COG0277	FAD linked oxidase domain protein
GKE56_RS07465	COG1309	transcriptional regulator
GKE56_RS07475	COG0406	alpha-ribazole phosphatase activity
GKE56_RS07485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GKE56_RS07500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GKE56_RS07505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GKE56_RS07510	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GKE56_RS07515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GKE56_RS07525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GKE56_RS07530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GKE56_RS07535	COG1530	ribonuclease E activity
GKE56_RS07580	COG1022	Amp-dependent synthetase and ligase
GKE56_RS07585	COG0772	Belongs to the SEDS family
GKE56_RS07595	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GKE56_RS07600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GKE56_RS07610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GKE56_RS07625	COG0779	Required for maturation of 30S ribosomal subunits
GKE56_RS07640	COG4565	transcriptional regulatory protein
GKE56_RS07665	COG2197	response regulator
GKE56_RS07705	COG2205	protein histidine kinase activity
GKE56_RS07720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GKE56_RS07720	COG1017	nitric oxide dioxygenase activity
GKE56_RS07735	COG0442	prolyl-tRNA aminoacylation
GKE56_RS07760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GKE56_RS07765	COG0750	zinc metalloprotease
GKE56_RS07770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GKE56_RS07775	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GKE56_RS07785	COG0010	Belongs to the arginase family
GKE56_RS07790	COG0778	Nitroreductase
GKE56_RS07805	COG1176	ABC-type spermidine putrescine transport system, permease component I
GKE56_RS07810	COG3842	ATPase activity
GKE56_RS07820	COG1012	belongs to the aldehyde dehydrogenase family
GKE56_RS07830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GKE56_RS07855	COG4762	Protein conserved in bacteria
GKE56_RS07870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GKE56_RS07875	COG0575	Belongs to the CDS family
GKE56_RS07880	COG0233	cytoplasmic translational termination
GKE56_RS07885	COG0528	UMP kinase activity
GKE56_RS07890	COG3590	peptidase
GKE56_RS07895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GKE56_RS07900	COG0052	Belongs to the universal ribosomal protein uS2 family
GKE56_RS07915	COG4974	Belongs to the 'phage' integrase family
GKE56_RS07935	COG0792	nuclease activity
GKE56_RS07945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GKE56_RS07950	COG0681	Belongs to the peptidase S26 family
GKE56_RS07955	COG0681	Belongs to the peptidase S26 family
GKE56_RS07960	COG0335	large ribosomal subunit rRNA binding
GKE56_RS07970	COG1609	Transcriptional regulator
GKE56_RS07975	COG0390	transport system, permease component
GKE56_RS07980	COG0336	Belongs to the RNA methyltransferase TrmD family
GKE56_RS07985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GKE56_RS07990	COG1837	Belongs to the UPF0109 family
GKE56_RS07995	COG0228	four-way junction DNA binding
GKE56_RS08010	COG3842	ATPase activity
GKE56_RS08015	COG4208	sulfate ABC transporter
GKE56_RS08020	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GKE56_RS08045	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GKE56_RS08075	COG1605	Chorismate mutase
GKE56_RS08075	COG0287	Prephenate dehydrogenase
GKE56_RS08085	COG1254	Belongs to the acylphosphatase family
GKE56_RS08090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GKE56_RS08095	COG0571	ribonuclease III activity
GKE56_RS08100	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GKE56_RS08115	COG2755	lipolytic protein G-D-S-L family
GKE56_RS08115	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GKE56_RS08120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GKE56_RS08135	COG0742	ribosomal rna small subunit methyltransferase
GKE56_RS08150	COG1461	Dihydroxyacetone kinase
GKE56_RS08155	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GKE56_RS08175	COG1181	Belongs to the D-alanine--D-alanine ligase family
GKE56_RS08185	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GKE56_RS08190	COG1920	GTP binding
GKE56_RS08195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GKE56_RS08200	COG0776	regulation of translation
GKE56_RS08205	COG0066	3-isopropylmalate dehydratase activity
GKE56_RS08210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GKE56_RS08215	COG1414	Transcriptional regulator
GKE56_RS08235	COG0179	Fumarylacetoacetate (FAA) hydrolase
GKE56_RS08240	COG4977	sequence-specific DNA binding
GKE56_RS08255	COG0137	argininosuccinate synthase activity
GKE56_RS08260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GKE56_RS08265	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GKE56_RS08270	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS08275	COG1012	belongs to the aldehyde dehydrogenase family
GKE56_RS08280	COG0174	glutamine synthetase
GKE56_RS08285	COG2186	Transcriptional regulator
GKE56_RS08290	COG0531	amino acid
GKE56_RS08295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GKE56_RS08300	COG0473	3-isopropylmalate dehydrogenase activity
GKE56_RS08305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GKE56_RS08310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GKE56_RS08325	COG0129	dihydroxy-acid dehydratase activity
GKE56_RS08335	COG1511	domain protein
GKE56_RS08370	COG2133	pyrroloquinoline quinone binding
GKE56_RS08375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GKE56_RS08380	COG0154	amidase activity
GKE56_RS08385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GKE56_RS08390	COG0346	lactoylglutathione lyase activity
GKE56_RS08395	COG0604	alcohol dehydrogenase
GKE56_RS08410	COG1250	3-hydroxyacyl-CoA dehydrogenase
GKE56_RS08420	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GKE56_RS08430	COG0667	Aldo Keto reductase
GKE56_RS08435	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKE56_RS08435	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKE56_RS08445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GKE56_RS08460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GKE56_RS08465	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GKE56_RS08470	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GKE56_RS08475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GKE56_RS08480	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GKE56_RS08485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GKE56_RS08490	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GKE56_RS08495	COG0356	it plays a direct role in the translocation of protons across the membrane
GKE56_RS08515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GKE56_RS08520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GKE56_RS08535	COG2890	protein-(glutamine-N5) methyltransferase activity
GKE56_RS08540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GKE56_RS08545	COG0254	rRNA binding
GKE56_RS08550	COG5002	protein histidine kinase activity
GKE56_RS08560	COG1216	Glycosyl transferase, family 2
GKE56_RS08570	COG0745	RESPONSE REGULATOR receiver
GKE56_RS08580	COG0083	homoserine kinase activity
GKE56_RS08585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GKE56_RS08590	COG0460	homoserine dehydrogenase
GKE56_RS08595	COG0019	diaminopimelate decarboxylase activity
GKE56_RS08600	COG0018	arginyl-trna synthetase
GKE56_RS08605	COG0745	RESPONSE REGULATOR receiver
GKE56_RS08620	COG1253	flavin adenine dinucleotide binding
GKE56_RS08635	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKE56_RS08635	COG0567	Dehydrogenase, E1 component
GKE56_RS08660	COG1088	dTDP-glucose 4,6-dehydratase activity
GKE56_RS08670	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GKE56_RS08690	COG0367	asparagine synthase
GKE56_RS08715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GKE56_RS08755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKE56_RS08770	COG0765	amino acid transport
GKE56_RS08775	COG1126	abc transporter atp-binding protein
GKE56_RS08815	COG5662	AntiSigma factor
GKE56_RS08820	COG1595	DNA-templated transcription, initiation
GKE56_RS08840	COG1136	(ABC) transporter
GKE56_RS08840	COG0577	efflux transmembrane transporter activity
GKE56_RS08845	COG0577	efflux transmembrane transporter activity
GKE56_RS08845	COG1136	(ABC) transporter
GKE56_RS08875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GKE56_RS08880	COG1162	GTPase activity
GKE56_RS08885	COG4608	Belongs to the ABC transporter superfamily
GKE56_RS08895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GKE56_RS08900	COG0601	transmembrane transport
GKE56_RS08915	COG0483	inositol monophosphate 1-phosphatase activity
GKE56_RS08930	COG1252	NADH dehydrogenase
GKE56_RS08935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GKE56_RS08950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GKE56_RS08955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GKE56_RS08995	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GKE56_RS09005	COG1176	ABC-type spermidine putrescine transport system, permease component I
GKE56_RS09010	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GKE56_RS09015	COG3842	ATPase activity
GKE56_RS09040	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GKE56_RS09045	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GKE56_RS09055	COG1684	flagellar biosynthetic protein fliR
GKE56_RS09065	COG1338	Plays a role in the flagellum-specific transport system
GKE56_RS09090	COG1360	Flagellar Motor Protein
GKE56_RS09095	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GKE56_RS09120	COG0741	lytic transglycosylase activity
GKE56_RS09130	COG1157	protein secretion by the type III secretion system
GKE56_RS09135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GKE56_RS09140	COG1766	The M ring may be actively involved in energy transduction
GKE56_RS09145	COG1677	Flagellar hook-basal body complex protein FliE
GKE56_RS09150	COG1558	bacterial-type flagellum-dependent cell motility
GKE56_RS09155	COG1815	bacterial-type flagellum-dependent cell motility
GKE56_RS09160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GKE56_RS09165	COG4786	Flagellar basal body rod
GKE56_RS09165	COG1256	bacterial-type flagellum assembly
GKE56_RS09185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GKE56_RS09190	COG1191	sigma factor activity
GKE56_RS09205	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GKE56_RS09275	COG2226	methyltransferase
GKE56_RS09280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GKE56_RS09290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKE56_RS09300	COG0640	Transcriptional regulator
GKE56_RS09375	COG2197	response regulator
GKE56_RS09410	COG2267	carboxylic ester hydrolase activity
GKE56_RS09415	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GKE56_RS09450	COG3550	peptidyl-serine autophosphorylation
GKE56_RS09535	COG3311	Transcriptional regulator
GKE56_RS09560	COG1615	UPF0182 protein
GKE56_RS09570	COG3480	Lon protease (S16) C-terminal proteolytic domain
GKE56_RS09635	COG3467	pyridoxamine 5'-phosphate
GKE56_RS09695	COG0513	Belongs to the DEAD box helicase family
GKE56_RS09705	COG1064	alcohol dehydrogenase
GKE56_RS09710	COG1192	Involved in chromosome partitioning
GKE56_RS09720	COG2095	MarC family integral membrane protein
GKE56_RS09735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GKE56_RS09740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GKE56_RS09760	COG1960	acyl-CoA dehydrogenase activity
GKE56_RS09780	COG1492	cobalamin metabolic process
GKE56_RS09810	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GKE56_RS09835	COG1797	cobyrinic acid a,c-diamide synthase activity
GKE56_RS09845	COG1648	precorrin-2 dehydrogenase activity
GKE56_RS09845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GKE56_RS09850	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GKE56_RS09880	COG2301	Belongs to the HpcH HpaI aldolase family
GKE56_RS09890	COG2239	Acts as a magnesium transporter
GKE56_RS09905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GKE56_RS09910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GKE56_RS09920	COG1595	DNA-templated transcription, initiation
GKE56_RS09935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GKE56_RS09950	COG1024	Enoyl-CoA hydratase
GKE56_RS09965	COG0519	Catalyzes the synthesis of GMP from XMP
GKE56_RS09985	COG1611	Belongs to the LOG family
GKE56_RS10050	COG4166	transmembrane transport
GKE56_RS10055	COG1217	gtp-binding protein TYPA
GKE56_RS10060	COG0494	nUDIX hydrolase
GKE56_RS10070	COG0747	negative chemotaxis
GKE56_RS10075	COG0601	transmembrane transport
GKE56_RS10085	COG4608	Belongs to the ABC transporter superfamily
GKE56_RS10090	COG2154	pterin-4-alpha-carbinolamine dehydratase
GKE56_RS10120	COG0012	GTP binding
GKE56_RS10130	COG2816	NAD+ diphosphatase activity
GKE56_RS10135	COG1322	Protein conserved in bacteria
GKE56_RS10140	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GKE56_RS10150	COG1722	exodeoxyribonuclease VII activity
GKE56_RS10180	COG1764	response to oxidative stress
GKE56_RS10185	COG0579	oxidoreductase
GKE56_RS10190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKE56_RS10195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GKE56_RS10200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GKE56_RS10220	COG0488	(ABC) transporter
GKE56_RS10230	COG0101	tRNA pseudouridine synthase activity
GKE56_RS10235	COG0203	ribosomal protein L17
GKE56_RS10240	COG0202	RNA polymerase activity
GKE56_RS10245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GKE56_RS10250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GKE56_RS10255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GKE56_RS10260	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GKE56_RS10265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GKE56_RS10275	COG0563	adenylate kinase activity
GKE56_RS10285	COG0200	Binds to the 23S rRNA
GKE56_RS10290	COG1841	ribosomal large subunit assembly
GKE56_RS10295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GKE56_RS10300	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GKE56_RS10305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GKE56_RS10310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GKE56_RS10320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GKE56_RS10325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GKE56_RS10330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GKE56_RS10335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GKE56_RS10340	COG0255	Belongs to the universal ribosomal protein uL29 family
GKE56_RS10345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GKE56_RS10350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GKE56_RS10360	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GKE56_RS10370	COG0089	rRNA binding
GKE56_RS10380	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GKE56_RS10385	COG0051	transcription antitermination factor activity, RNA binding
GKE56_RS10405	COG0049	tRNA binding
GKE56_RS10410	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GKE56_RS10415	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GKE56_RS10420	COG0085	RNA polymerase activity
GKE56_RS10465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GKE56_RS10475	COG1127	ABC transporter
GKE56_RS10480	COG0222	ribosome binding
GKE56_RS10495	COG0081	regulation of translation
GKE56_RS10500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GKE56_RS10530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GKE56_RS10535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GKE56_RS10545	COG2030	dehydratase
GKE56_RS10550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GKE56_RS10565	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GKE56_RS10585	COG0746	molybdenum cofactor guanylyltransferase activity
GKE56_RS10610	COG0702	epimerase
GKE56_RS10620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKE56_RS10665	COG2197	response regulator
GKE56_RS10680	COG1666	GTP binding
GKE56_RS10685	COG0515	serine threonine protein kinase
GKE56_RS10695	COG2755	lipolytic protein G-D-S-L family
GKE56_RS10700	COG0501	Belongs to the peptidase M48B family
GKE56_RS10705	COG1007	ATP synthesis coupled electron transport
GKE56_RS10710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKE56_RS10715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GKE56_RS10720	COG0713	ATP synthesis coupled electron transport
GKE56_RS10730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKE56_RS10735	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GKE56_RS10740	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKE56_RS10745	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKE56_RS10750	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKE56_RS10770	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GKE56_RS10770	COG0674	pyruvate-flavodoxin oxidoreductase activity
GKE56_RS10775	COG1013	pyruvate-flavodoxin oxidoreductase activity
GKE56_RS10785	COG0142	geranyltranstransferase activity
GKE56_RS10810	COG0839	Belongs to the complex I subunit 6 family
GKE56_RS10815	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKE56_RS10820	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GKE56_RS10825	COG1034	ATP synthesis coupled electron transport
GKE56_RS10845	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKE56_RS10850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKE56_RS10865	COG2226	methyltransferase
GKE56_RS10870	COG1169	isochorismate synthase
GKE56_RS10875	COG4214	carbohydrate transport
GKE56_RS10890	COG2160	L-arabinose isomerase activity
GKE56_RS10905	COG1609	Transcriptional regulator
GKE56_RS10910	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GKE56_RS10955	COG4948	Mandelate Racemase Muconate Lactonizing
GKE56_RS11005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GKE56_RS11015	COG0785	Cytochrome C biogenesis protein
GKE56_RS11025	COG0406	alpha-ribazole phosphatase activity
GKE56_RS11030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GKE56_RS11040	COG2353	YceI-like domain
GKE56_RS11045	COG0113	porphobilinogen synthase activity
GKE56_RS11050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GKE56_RS11050	COG1648	precorrin-2 dehydrogenase activity
GKE56_RS11060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GKE56_RS11065	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GKE56_RS11110	COG0569	domain protein
GKE56_RS11125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GKE56_RS11130	COG0506	proline dehydrogenase activity
GKE56_RS11155	COG0640	Transcriptional regulator
GKE56_RS11160	COG1309	transcriptional regulator
GKE56_RS11165	COG1082	Xylose isomerase domain protein TIM barrel
GKE56_RS11170	COG0248	Ppx GppA phosphatase
GKE56_RS11180	COG2226	methyltransferase
GKE56_RS11190	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GKE56_RS11195	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GKE56_RS11210	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GKE56_RS11255	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GKE56_RS11265	COG3285	dna ligase
GKE56_RS11265	COG1793	dna ligase
GKE56_RS11290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GKE56_RS11295	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GKE56_RS11300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GKE56_RS11325	COG0649	NAD binding
GKE56_RS11335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GKE56_RS11350	COG0302	gtp cyclohydrolase
GKE56_RS11365	COG0037	tRNA processing
GKE56_RS11380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GKE56_RS11385	COG0791	NLP P60 protein
GKE56_RS11385	COG3883	PFAM NLP P60 protein
GKE56_RS11405	COG0596	Alpha beta hydrolase
GKE56_RS11425	COG2018	Roadblock/LC7 domain
GKE56_RS11460	COG0745	RESPONSE REGULATOR receiver
GKE56_RS11490	COG0470	DNA polymerase III
GKE56_RS11500	COG0789	Transcriptional regulator
GKE56_RS11520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GKE56_RS11520	COG1754	DNA topoisomerase type I activity
GKE56_RS11525	COG3384	dioxygenase
GKE56_RS11530	COG3321	synthase
GKE56_RS11530	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS11530	COG0604	alcohol dehydrogenase
GKE56_RS11570	COG2890	protein-(glutamine-N5) methyltransferase activity
GKE56_RS11580	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GKE56_RS11585	COG1366	Belongs to the anti-sigma-factor antagonist family
GKE56_RS11590	COG1111	helicase
GKE56_RS11590	COG1205	dead DEAH box helicase
GKE56_RS11645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GKE56_RS11650	COG0584	glycerophosphoryl diester phosphodiesterase
GKE56_RS11660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GKE56_RS11670	COG0596	Alpha beta hydrolase
GKE56_RS11695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKE56_RS11735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GKE56_RS11745	COG1408	metallophosphoesterase
GKE56_RS11785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKE56_RS11800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKE56_RS11830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GKE56_RS11865	COG1131	(ABC) transporter
GKE56_RS11880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GKE56_RS11905	COG0433	COG0433 Predicted ATPase
GKE56_RS11935	COG2197	response regulator
GKE56_RS11940	COG4585	Histidine kinase
GKE56_RS11945	COG3387	PFAM Glycoside hydrolase 15-related
GKE56_RS11960	COG0513	Belongs to the DEAD box helicase family
GKE56_RS11985	COG2814	Major facilitator Superfamily
GKE56_RS11990	COG0586	Pfam SNARE associated Golgi protein
GKE56_RS11995	COG0590	tRNA wobble adenosine to inosine editing
GKE56_RS11995	COG0037	tRNA processing
GKE56_RS12000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GKE56_RS12015	COG0531	amino acid
GKE56_RS12025	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GKE56_RS12040	COG1741	Belongs to the pirin family
GKE56_RS12045	COG0318	PFAM AMP-dependent synthetase and ligase
GKE56_RS12050	COG0488	(ABC) transporter
GKE56_RS12055	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS12070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GKE56_RS12075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GKE56_RS12095	COG0702	epimerase
GKE56_RS12100	COG4221	oxidoreductase activity
GKE56_RS12110	COG2197	response regulator
GKE56_RS12115	COG4585	Histidine kinase
GKE56_RS12140	COG3153	acetyltransferase
GKE56_RS12150	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GKE56_RS12160	COG0589	response to stress
GKE56_RS12180	COG1609	Transcriptional regulator
GKE56_RS12195	COG0745	RESPONSE REGULATOR receiver
GKE56_RS12200	COG2205	protein histidine kinase activity
GKE56_RS12205	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GKE56_RS12205	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GKE56_RS12210	COG1215	transferase activity, transferring glycosyl groups
GKE56_RS12230	COG0768	penicillin binding
GKE56_RS12235	COG1278	Cold shock
GKE56_RS12245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GKE56_RS12265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GKE56_RS12295	COG1045	serine acetyltransferase
GKE56_RS12305	COG0247	lactate metabolic process
GKE56_RS12305	COG2181	nitrate reductase activity
GKE56_RS12310	COG0204	Acyl-transferase
GKE56_RS12330	COG1174	glycine betaine transport
GKE56_RS12335	COG1174	glycine betaine transport
GKE56_RS12345	COG2986	histidine ammonia-lyase
GKE56_RS12355	COG0717	Belongs to the dCTP deaminase family
GKE56_RS12505	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKE56_RS12510	COG0022	dehydrogenase e1 component
GKE56_RS12520	COG0667	Aldo Keto reductase
GKE56_RS12525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GKE56_RS12530	COG1950	PFAM Membrane protein of
GKE56_RS12540	COG4565	transcriptional regulatory protein
GKE56_RS12545	COG3290	protein histidine kinase activity
GKE56_RS12555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GKE56_RS12575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GKE56_RS12585	COG0667	Aldo Keto reductase
GKE56_RS12590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GKE56_RS12615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKE56_RS12620	COG0561	phosphatase activity
GKE56_RS12630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GKE56_RS12645	COG1597	lipid kinase activity
GKE56_RS12645	COG1803	Methylglyoxal synthase
GKE56_RS12650	COG0671	phosphoesterase, PA-phosphatase related
GKE56_RS12660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GKE56_RS12665	COG0077	Prephenate dehydratase
GKE56_RS12715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GKE56_RS12740	COG0425	Belongs to the sulfur carrier protein TusA family
GKE56_RS12740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GKE56_RS12745	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GKE56_RS12780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GKE56_RS12795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GKE56_RS12830	COG1716	ATPase activity
GKE56_RS12845	COG0768	penicillin binding
GKE56_RS12850	COG0515	serine threonine protein kinase
GKE56_RS12855	COG0515	serine threonine protein kinase
GKE56_RS12860	COG0515	serine threonine protein kinase
GKE56_RS12875	COG3764	Sortase (surface protein transpeptidase)
GKE56_RS12890	COG0705	Rhomboid family
GKE56_RS12925	COG5479	isomerase activity
GKE56_RS12925	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GKE56_RS12940	COG0709	Synthesizes selenophosphate from selenide and ATP
GKE56_RS12945	COG3422	double-strand break repair
GKE56_RS12990	COG0187	DNA topoisomerase II activity
GKE56_RS12995	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GKE56_RS13000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GKE56_RS13010	COG0592	DNA-directed DNA polymerase activity
GKE56_RS13015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GKE56_RS13020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GKE56_RS13025	COG0594	ribonuclease P activity
GKE56_RS13030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GKE56_RS13045	COG0357	Ribosomal RNA small subunit methyltransferase G
GKE56_RS13050	COG1192	Involved in chromosome partitioning
GKE56_RS13060	COG3409	Peptidoglycan-binding domain 1 protein
GKE56_RS13060	COG0860	N-Acetylmuramoyl-L-alanine amidase
GKE56_RS13065	COG3118	belongs to the thioredoxin family
GKE56_RS13070	COG0492	ferredoxin-NADP+ reductase activity
GKE56_RS13080	COG1595	DNA-templated transcription, initiation
GKE56_RS13110	COG0617	tRNA 3'-terminal CCA addition
GKE56_RS13125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GKE56_RS13135	COG0360	Binds together with S18 to 16S ribosomal RNA
GKE56_RS13150	COG0359	binds to the 23S rRNA
GKE56_RS13165	COG0673	inositol 2-dehydrogenase activity
GKE56_RS13170	COG1082	Xylose isomerase domain protein TIM barrel
GKE56_RS13175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKE56_RS13185	COG3718	enzyme involved in inositol metabolism
GKE56_RS13190	COG3962	Belongs to the TPP enzyme family
GKE56_RS13195	COG0405	Gamma-glutamyltransferase
GKE56_RS13215	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GKE56_RS13270	COG1126	abc transporter atp-binding protein
GKE56_RS13305	COG0477	Major facilitator Superfamily
GKE56_RS13335	COG1937	Protein conserved in bacteria
GKE56_RS13350	COG1070	Carbohydrate kinase
GKE56_RS13355	COG1063	alcohol dehydrogenase
GKE56_RS13360	COG0246	Mannitol dehydrogenase
GKE56_RS13365	COG0395	ABC-type sugar transport system, permease component
GKE56_RS13385	COG1609	Transcriptional regulator
GKE56_RS13390	COG1653	transport
GKE56_RS13400	COG0395	ABC-type sugar transport system, permease component
GKE56_RS13430	COG4214	carbohydrate transport
GKE56_RS13445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GKE56_RS13465	COG0604	alcohol dehydrogenase
GKE56_RS13465	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS13465	COG3321	synthase
GKE56_RS13485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GKE56_RS13500	COG0442	prolyl-tRNA aminoacylation
GKE56_RS13515	COG1228	amidohydrolase
GKE56_RS13525	COG4721	ABC-type cobalt transport system, permease component
GKE56_RS13555	COG2337	Toxic component of a toxin-antitoxin (TA) module
GKE56_RS13570	COG0443	Heat shock 70 kDa protein
GKE56_RS13575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GKE56_RS13580	COG0484	heat shock protein binding
GKE56_RS13585	COG0789	Transcriptional regulator
GKE56_RS13615	COG0542	response to heat
GKE56_RS13640	COG0477	Major facilitator Superfamily
GKE56_RS13660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GKE56_RS13665	COG1704	LemA family
GKE56_RS13730	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GKE56_RS13740	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GKE56_RS13745	COG0047	phosphoribosylformylglycinamidine synthase activity
GKE56_RS13750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GKE56_RS13755	COG2205	protein histidine kinase activity
GKE56_RS13765	COG0673	inositol 2-dehydrogenase activity
GKE56_RS13775	COG1063	alcohol dehydrogenase
GKE56_RS13790	COG1595	DNA-templated transcription, initiation
GKE56_RS13830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GKE56_RS13870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GKE56_RS13885	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
GKE56_RS13890	COG0154	amidase activity
GKE56_RS13895	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GKE56_RS13930	COG1796	DNA polymerase
GKE56_RS13930	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GKE56_RS13940	COG0300	oxidoreductase activity
GKE56_RS13970	COG1012	belongs to the aldehyde dehydrogenase family
GKE56_RS13985	COG1228	amidohydrolase
GKE56_RS13995	COG1414	Transcriptional regulator
GKE56_RS14000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GKE56_RS14010	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GKE56_RS14015	COG0747	negative chemotaxis
GKE56_RS14020	COG0601	transmembrane transport
GKE56_RS14025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GKE56_RS14030	COG0444	Belongs to the ABC transporter superfamily
GKE56_RS14045	COG0673	inositol 2-dehydrogenase activity
GKE56_RS14050	COG1735	metal-dependent hydrolase with the TIM-barrel fold
GKE56_RS14085	COG4647	ligase activity
GKE56_RS14090	COG0145	ligase activity
GKE56_RS14110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GKE56_RS14120	COG1129	ABC transporter
GKE56_RS14125	COG1172	Belongs to the binding-protein-dependent transport system permease family
GKE56_RS14135	COG0154	amidase activity
GKE56_RS14145	COG4221	oxidoreductase activity
GKE56_RS14150	COG0667	Aldo Keto reductase
GKE56_RS14155	COG3619	membrane
GKE56_RS14170	COG0583	DNA-binding transcription factor activity
GKE56_RS14175	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS14215	COG0791	NLP P60 protein
GKE56_RS14335	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS14355	COG4214	carbohydrate transport
GKE56_RS14360	COG1129	ABC transporter
GKE56_RS14365	COG1879	ABC-type sugar transport system periplasmic component
GKE56_RS14385	COG1802	Transcriptional regulator
GKE56_RS14395	COG1960	acyl-CoA dehydrogenase activity
GKE56_RS14400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GKE56_RS14405	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
GKE56_RS14460	COG2197	response regulator
GKE56_RS14505	COG4974	Belongs to the 'phage' integrase family
GKE56_RS14525	COG0358	DNA primase activity
GKE56_RS14545	COG0582	viral genome integration into host DNA
GKE56_RS14570	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GKE56_RS14640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GKE56_RS14665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GKE56_RS14670	COG0456	acetyltransferase
GKE56_RS14675	COG0745	RESPONSE REGULATOR receiver
GKE56_RS14695	COG4044	May play a role in the intracellular transport of hydrophobic ligands
GKE56_RS14710	COG1316	TRANSCRIPTIONal
GKE56_RS14715	COG0735	belongs to the Fur family
GKE56_RS14725	COG0489	protein tyrosine kinase activity
GKE56_RS14750	COG1490	D-aminoacyl-tRNA deacylase activity
GKE56_RS14775	COG0438	transferase activity, transferring glycosyl groups
GKE56_RS14785	COG0588	phosphoglycerate mutase activity
GKE56_RS14795	COG5002	protein histidine kinase activity
GKE56_RS14815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GKE56_RS14820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GKE56_RS14825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GKE56_RS14830	COG0215	cysteine-tRNA ligase activity
GKE56_RS14835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKE56_RS14860	COG3842	ATPase activity
GKE56_RS14875	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GKE56_RS14880	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GKE56_RS14915	COG0489	protein tyrosine kinase activity
GKE56_RS14990	COG1793	dna ligase
GKE56_RS14990	COG3285	dna ligase
GKE56_RS15020	COG2755	lipolytic protein G-D-S-L family
GKE56_RS15020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GKE56_RS15075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GKE56_RS15085	COG1104	cysteine desulfurase activity
GKE56_RS15105	COG3191	aminopeptidase activity
GKE56_RS15110	COG0459	protein refolding
GKE56_RS15120	COG0577	efflux transmembrane transporter activity
GKE56_RS15120	COG1136	(ABC) transporter
GKE56_RS15145	COG0583	DNA-binding transcription factor activity
GKE56_RS15155	COG3973	AAA domain
GKE56_RS15160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GKE56_RS15165	COG2205	protein histidine kinase activity
GKE56_RS15170	COG0745	RESPONSE REGULATOR receiver
GKE56_RS15200	COG2017	converts alpha-aldose to the beta-anomer
GKE56_RS15210	COG1278	Cold shock
GKE56_RS15225	COG2252	PERMEase
GKE56_RS15235	COG2814	Major facilitator Superfamily
GKE56_RS15280	COG0259	pyridoxamine-phosphate oxidase activity
GKE56_RS15290	COG0800	Aldolase
GKE56_RS15335	COG0366	Alpha amylase catalytic
GKE56_RS15340	COG1846	Transcriptional regulator
GKE56_RS15395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GKE56_RS15465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GKE56_RS15475	COG3609	addiction module antidote protein, CC2985 family
GKE56_RS15485	COG4974	Belongs to the 'phage' integrase family
GKE56_RS15510	COG0642	Histidine kinase
GKE56_RS15515	COG5002	protein histidine kinase activity
GKE56_RS15525	COG0745	RESPONSE REGULATOR receiver
GKE56_RS15540	COG0028	Belongs to the TPP enzyme family
GKE56_RS15545	COG0069	glutamate synthase activity
GKE56_RS15590	COG1970	mechanosensitive ion channel activity
GKE56_RS15600	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GKE56_RS15610	COG3263	regulation of cellular component size
GKE56_RS15620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GKE56_RS15625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GKE56_RS15635	COG0315	cyclic pyranopterin monophosphate synthase activity
GKE56_RS15640	COG0521	Mo-molybdopterin cofactor biosynthetic process
GKE56_RS15670	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GKE56_RS15705	COG3386	PFAM SMP-30 Gluconolaconase
GKE56_RS15715	COG0800	Aldolase
GKE56_RS15720	COG1846	Transcriptional regulator
GKE56_RS15720	COG1940	carbohydrate kinase activity
GKE56_RS15725	COG4948	Mandelate Racemase Muconate Lactonizing
GKE56_RS15730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKE56_RS15735	COG1175	transmembrane transport
GKE56_RS15740	COG0395	ABC-type sugar transport system, permease component
GKE56_RS15745	COG0657	acetylesterase activity
GKE56_RS15755	COG1131	(ABC) transporter
GKE56_RS15775	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GKE56_RS15785	COG1846	Transcriptional regulator
GKE56_RS15785	COG1940	carbohydrate kinase activity
GKE56_RS15790	COG1653	transport
GKE56_RS15795	COG1175	transmembrane transport
GKE56_RS15800	COG0395	ABC-type sugar transport system, permease component
GKE56_RS15805	COG3387	PFAM Glycoside hydrolase 15-related
GKE56_RS15830	COG1028	Short-chain dehydrogenase reductase Sdr
GKE56_RS15865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GKE56_RS15870	COG0084	hydrolase, TatD family'
GKE56_RS15875	COG3583	domain protein
GKE56_RS15880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GKE56_RS15890	COG0488	(ABC) transporter
GKE56_RS15895	COG1846	Transcriptional regulator
GKE56_RS15900	COG4106	trans-aconitate 2-methyltransferase activity
GKE56_RS15905	COG1309	transcriptional regulator
GKE56_RS15925	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GKE56_RS15930	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GKE56_RS15945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GKE56_RS15950	COG0193	aminoacyl-tRNA hydrolase activity
GKE56_RS15970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKE56_RS15995	COG0438	transferase activity, transferring glycosyl groups
GKE56_RS16000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GKE56_RS16060	COG0438	transferase activity, transferring glycosyl groups
GKE56_RS16095	COG1522	sequence-specific DNA binding
GKE56_RS16095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKE56_RS16100	COG2313	pseudouridylate synthase activity
GKE56_RS16175	COG0183	Belongs to the thiolase family
GKE56_RS16180	COG2755	lipolytic protein G-D-S-L family
GKE56_RS16195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GKE56_RS16230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GKE56_RS16240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GKE56_RS16260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GKE56_RS16265	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GKE56_RS16280	COG1072	(Pantothenic acid kinase))
GKE56_RS16285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GKE56_RS16290	COG0736	holo-[acyl-carrier-protein] synthase activity
GKE56_RS16300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GKE56_RS16310	COG0802	atpase or kinase
GKE56_RS16320	COG0456	acetyltransferase
GKE56_RS16325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GKE56_RS16330	COG1957	nucleoside hydrolase
GKE56_RS16335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKE56_RS16370	COG2226	methyltransferase
GKE56_RS16410	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GKE56_RS16495	COG3655	Transcriptional regulator
GKE56_RS16510	COG1063	alcohol dehydrogenase
GKE56_RS16525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GKE56_RS16570	COG2814	Major facilitator Superfamily
GKE56_RS16600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GKE56_RS16605	COG0459	protein refolding
GKE56_RS16635	COG0516	GMP reductase activity
GKE56_RS16660	COG1132	(ABC) transporter
GKE56_RS16665	COG1132	(ABC) transporter
GKE56_RS16725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GKE56_RS16730	COG0438	transferase activity, transferring glycosyl groups
GKE56_RS16755	COG2197	response regulator