locus-tag	class	description
C6Y53_RS00020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C6Y53_RS00020	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6Y53_RS00030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y53_RS00035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C6Y53_RS00080	COG1494	fructose-1,6-bisphosphatase
C6Y53_RS00085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C6Y53_RS00100	COG1238	metal cluster binding
C6Y53_RS00110	COG1652	LysM domain
C6Y53_RS00120	COG0010	Belongs to the arginase family
C6Y53_RS00130	COG0175	sulfate reduction
C6Y53_RS00145	COG3845	ABC transporter
C6Y53_RS00150	COG4603	Belongs to the binding-protein-dependent transport system permease family
C6Y53_RS00155	COG1079	Belongs to the binding-protein-dependent transport system permease family
C6Y53_RS00160	COG0402	S-adenosylhomocysteine deaminase activity
C6Y53_RS00175	COG0725	ABC transporter, periplasmic molybdate-binding protein
C6Y53_RS00180	COG4149	molybdate abc transporter
C6Y53_RS00185	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C6Y53_RS00190	COG3750	Belongs to the UPF0335 family
C6Y53_RS00210	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C6Y53_RS00250	COG0745	RESPONSE REGULATOR receiver
C6Y53_RS00265	COG0559	Belongs to the binding-protein-dependent transport system permease family
C6Y53_RS00270	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6Y53_RS00280	COG0410	ABC transporter
C6Y53_RS00290	COG0747	negative chemotaxis
C6Y53_RS00300	COG0444	Belongs to the ABC transporter superfamily
C6Y53_RS00305	COG4608	Belongs to the ABC transporter superfamily
C6Y53_RS00325	COG1396	sequence-specific DNA binding
C6Y53_RS00330	COG1126	abc transporter atp-binding protein
C6Y53_RS00335	COG0765	amino acid transport
C6Y53_RS00345	COG0765	amino acid transport
C6Y53_RS00350	COG0583	DNA-binding transcription factor activity
C6Y53_RS00360	COG0511	ligase activity, forming carbon-carbon bonds
C6Y53_RS00365	COG0439	Biotin carboxylase
C6Y53_RS00370	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C6Y53_RS00420	COG1132	(ABC) transporter
C6Y53_RS00430	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y53_RS00435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6Y53_RS00440	COG0825	malonyl-CoA metabolic process
C6Y53_RS00445	COG4977	sequence-specific DNA binding
C6Y53_RS00445	COG1917	Cupin 2, conserved barrel domain protein
C6Y53_RS00460	COG3246	L-lysine catabolic process to acetate
C6Y53_RS00465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6Y53_RS00470	COG1121	(ABC) transporter
C6Y53_RS00475	COG0735	belongs to the Fur family
C6Y53_RS00480	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C6Y53_RS00485	COG0740	serine-type endopeptidase activity
C6Y53_RS00490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C6Y53_RS00500	COG3396	Phenylacetate-CoA oxygenase
C6Y53_RS00505	COG3460	Phenylacetate-CoA oxygenase
C6Y53_RS00510	COG3396	Phenylacetate-CoA oxygenase
C6Y53_RS00515	COG2151	metal-sulfur cluster biosynthetic enzyme
C6Y53_RS00520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6Y53_RS00635	COG2072	flavoprotein involved in K transport
C6Y53_RS00650	COG2259	Doxx family
C6Y53_RS00655	COG2130	NADP-dependent
C6Y53_RS00660	COG0483	inositol monophosphate 1-phosphatase activity
C6Y53_RS00665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6Y53_RS00675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C6Y53_RS00680	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C6Y53_RS00685	COG4133	protoheme IX ABC transporter activity
C6Y53_RS00690	COG3737	Protein of unknown function (DUF498/DUF598)
C6Y53_RS00700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6Y53_RS00705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6Y53_RS00710	COG1862	Preprotein translocase
C6Y53_RS00715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C6Y53_RS00720	COG3239	Fatty acid desaturase
C6Y53_RS00725	COG2095	MarC family integral membrane protein
C6Y53_RS00730	COG1160	GTP binding
C6Y53_RS00750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6Y53_RS00760	COG5265	(ABC) transporter
C6Y53_RS00785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C6Y53_RS00785	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6Y53_RS00800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y53_RS00805	COG4235	cytochrome complex assembly
C6Y53_RS00810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C6Y53_RS00830	COG0489	protein tyrosine kinase activity
C6Y53_RS00870	COG3383	formate dehydrogenase (NAD+) activity
C6Y53_RS00870	COG0243	molybdopterin cofactor binding
C6Y53_RS00875	COG0437	4 iron, 4 sulfur cluster binding
C6Y53_RS00890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y53_RS00895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y53_RS00900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y53_RS00905	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C6Y53_RS00930	COG2873	o-acetylhomoserine
C6Y53_RS00935	COG2968	Membrane
C6Y53_RS00955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6Y53_RS00955	COG0475	glutathione-regulated potassium exporter activity
C6Y53_RS00960	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C6Y53_RS00965	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C6Y53_RS00970	COG1329	Transcriptional regulator
C6Y53_RS00975	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C6Y53_RS00980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C6Y53_RS01000	COG2267	carboxylic ester hydrolase activity
C6Y53_RS01020	COG2226	methyltransferase
C6Y53_RS01025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C6Y53_RS01035	COG0116	Belongs to the methyltransferase superfamily
C6Y53_RS01050	COG0564	pseudouridine synthase activity
C6Y53_RS01065	COG1960	acyl-CoA dehydrogenase activity
C6Y53_RS01070	COG0583	DNA-binding transcription factor activity
C6Y53_RS01075	COG5002	protein histidine kinase activity
C6Y53_RS01080	COG0626	cystathionine gamma-synthase activity
C6Y53_RS01090	COG0194	GDP metabolic process
C6Y53_RS01095	COG1561	YicC-like family, N-terminal region
C6Y53_RS01105	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C6Y53_RS01115	COG2133	pyrroloquinoline quinone binding
C6Y53_RS01150	COG0433	COG0433 Predicted ATPase
C6Y53_RS01170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6Y53_RS01175	COG2989	Protein conserved in bacteria
C6Y53_RS01180	COG3108	Peptidase M15
C6Y53_RS01185	COG1217	gtp-binding protein TYPA
C6Y53_RS01190	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y53_RS01195	COG0166	Belongs to the GPI family
C6Y53_RS01205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C6Y53_RS01215	COG5425	PFAM Usg family protein
C6Y53_RS01220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6Y53_RS01225	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C6Y53_RS01230	COG1612	heme a metabolic process
C6Y53_RS01240	COG0352	thiamine-phosphate diphosphorylase activity
C6Y53_RS01250	COG2313	pseudouridylate synthase activity
C6Y53_RS01265	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS01270	COG4166	transmembrane transport
C6Y53_RS01290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6Y53_RS01300	COG2814	Major facilitator Superfamily
C6Y53_RS01385	COG0504	CTP synthase activity
C6Y53_RS01390	COG1136	(ABC) transporter
C6Y53_RS01400	COG0442	prolyl-tRNA aminoacylation
C6Y53_RS01405	COG3273	potassium ion transport
C6Y53_RS01405	COG0471	metal ion transport
C6Y53_RS01410	COG0628	permease
C6Y53_RS01420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C6Y53_RS01425	COG0248	Ppx GppA phosphatase
C6Y53_RS01440	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C6Y53_RS01455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6Y53_RS01455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6Y53_RS01470	COG4770	biotin carboxylase activity
C6Y53_RS01490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6Y53_RS01495	COG2814	Major facilitator Superfamily
C6Y53_RS01500	COG1396	sequence-specific DNA binding
C6Y53_RS01500	COG3800	Transcriptional regulator
C6Y53_RS01515	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C6Y53_RS01520	COG0625	glutathione transferase activity
C6Y53_RS01530	COG3119	arylsulfatase activity
C6Y53_RS01535	COG1309	transcriptional regulator
C6Y53_RS01560	COG0217	transcriptional regulatory protein
C6Y53_RS01565	COG3273	potassium ion transport
C6Y53_RS01565	COG0471	metal ion transport
C6Y53_RS01570	COG0519	Catalyzes the synthesis of GMP from XMP
C6Y53_RS01570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6Y53_RS01585	COG0471	metal ion transport
C6Y53_RS01585	COG3273	potassium ion transport
C6Y53_RS01595	COG1692	metallophosphoesterase
C6Y53_RS01605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C6Y53_RS01610	COG2239	Acts as a magnesium transporter
C6Y53_RS01615	COG0402	S-adenosylhomocysteine deaminase activity
C6Y53_RS01620	COG1393	Belongs to the ArsC family
C6Y53_RS01625	COG1278	Cold shock
C6Y53_RS01630	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C6Y53_RS01645	COG1846	Transcriptional regulator
C6Y53_RS01670	COG0534	Mate efflux family protein
C6Y53_RS01675	COG2326	polyphosphate kinase activity
C6Y53_RS01680	COG0596	Alpha beta hydrolase
C6Y53_RS01690	COG0187	DNA topoisomerase II activity
C6Y53_RS01745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6Y53_RS01765	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C6Y53_RS01770	COG0193	aminoacyl-tRNA hydrolase activity
C6Y53_RS01790	COG0133	tryptophan synthase activity
C6Y53_RS01795	COG0135	phosphoribosylanthranilate isomerase activity
C6Y53_RS01805	COG0776	regulation of translation
C6Y53_RS01810	COG0539	negative regulation of cytoplasmic translation
C6Y53_RS01820	COG3588	fructose-bisphosphate aldolase
C6Y53_RS01835	COG0785	Cytochrome C biogenesis protein
C6Y53_RS01840	COG0425	Belongs to the sulfur carrier protein TusA family
C6Y53_RS01845	COG1530	ribonuclease E activity
C6Y53_RS01850	COG2204	response regulator
C6Y53_RS01860	COG0047	phosphoribosylformylglycinamidine synthase activity
C6Y53_RS01865	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6Y53_RS01870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C6Y53_RS01880	COG0646	methionine synthase
C6Y53_RS01880	COG1410	methionine synthase
C6Y53_RS01895	COG5012	cobalamin binding
C6Y53_RS01905	COG2166	iron-sulfur cluster assembly
C6Y53_RS01915	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C6Y53_RS01920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C6Y53_RS01925	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C6Y53_RS02205	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C6Y53_RS02210	COG4136	ATPase activity
C6Y53_RS02215	COG4135	transport system, permease component
C6Y53_RS02220	COG4134	Bacterial extracellular solute-binding protein
C6Y53_RS02225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6Y53_RS02230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6Y53_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS02245	COG0251	oxidation-reduction process
C6Y53_RS02275	COG0673	inositol 2-dehydrogenase activity
C6Y53_RS02285	COG3964	amidohydrolase
C6Y53_RS02295	COG3119	arylsulfatase activity
C6Y53_RS02300	COG1309	transcriptional regulator
C6Y53_RS02315	COG5507	3-demethylubiquinone-9 3-methyltransferase
C6Y53_RS02335	COG3421	Type III restriction
C6Y53_RS02360	COG1802	Transcriptional regulator
C6Y53_RS02365	COG0583	DNA-binding transcription factor activity
C6Y53_RS02390	COG0525	valine-tRNA ligase activity
C6Y53_RS02400	COG1024	Enoyl-CoA hydratase
C6Y53_RS02405	COG2832	Protein of unknown function (DUF454)
C6Y53_RS02410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6Y53_RS02415	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C6Y53_RS02420	COG1132	(ABC) transporter
C6Y53_RS02430	COG0354	folic acid binding
C6Y53_RS02445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C6Y53_RS02455	COG1492	cobalamin metabolic process
C6Y53_RS02465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C6Y53_RS02505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C6Y53_RS02510	COG0343	queuine tRNA-ribosyltransferase activity
C6Y53_RS02515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C6Y53_RS02520	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C6Y53_RS02535	COG0745	RESPONSE REGULATOR receiver
C6Y53_RS02540	COG0346	lactoylglutathione lyase activity
C6Y53_RS02555	COG0778	Nitroreductase
C6Y53_RS02570	COG1872	DUF167
C6Y53_RS02585	COG0189	ligase activity
C6Y53_RS02585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6Y53_RS02590	COG0189	ligase activity
C6Y53_RS02590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6Y53_RS02605	COG1739	Uncharacterized protein family UPF0029
C6Y53_RS02625	COG1435	thymidine kinase activity
C6Y53_RS02630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6Y53_RS02635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6Y53_RS02655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C6Y53_RS02665	COG1496	oxidoreductase activity
C6Y53_RS02680	COG0006	proline dipeptidase activity
C6Y53_RS02700	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6Y53_RS02710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C6Y53_RS02715	COG0849	cell division
C6Y53_RS02720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C6Y53_RS02725	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6Y53_RS02730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C6Y53_RS02740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6Y53_RS02745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C6Y53_RS02755	COG2081	HI0933 family
C6Y53_RS02760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C6Y53_RS02765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6Y53_RS02775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6Y53_RS02780	COG0768	penicillin binding
C6Y53_RS02790	COG0275	rRNA processing
C6Y53_RS02795	COG2001	Belongs to the MraZ family
C6Y53_RS02805	COG0210	DNA helicase
C6Y53_RS02815	COG4948	Mandelate Racemase Muconate Lactonizing
C6Y53_RS02820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y53_RS02830	COG3842	ATPase activity
C6Y53_RS02840	COG1177	transmembrane transport
C6Y53_RS02850	COG1162	GTPase activity
C6Y53_RS02855	COG2267	carboxylic ester hydrolase activity
C6Y53_RS02880	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C6Y53_RS02890	COG2986	histidine ammonia-lyase
C6Y53_RS02895	COG1228	amidohydrolase
C6Y53_RS02910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6Y53_RS02920	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS02955	COG0659	secondary active sulfate transmembrane transporter activity
C6Y53_RS02965	COG0789	Transcriptional regulator
C6Y53_RS02970	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C6Y53_RS02980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6Y53_RS02995	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS03015	COG3346	SURF1 family
C6Y53_RS03025	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C6Y53_RS03030	COG0109	protoheme IX farnesyltransferase activity
C6Y53_RS03040	COG0312	modulator of DNA gyrase
C6Y53_RS03045	COG0758	DNA mediated transformation
C6Y53_RS03050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6Y53_RS03050	COG1754	DNA topoisomerase type I activity
C6Y53_RS03070	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C6Y53_RS03075	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C6Y53_RS03095	COG4964	Belongs to the GSP D family
C6Y53_RS03150	COG1115	amino acid carrier protein
C6Y53_RS03155	COG1201	RNA secondary structure unwinding
C6Y53_RS03165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C6Y53_RS03175	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C6Y53_RS03185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C6Y53_RS03190	COG0037	tRNA processing
C6Y53_RS03200	COG2885	chlorophyll binding
C6Y53_RS03205	COG0823	Involved in the tonB-independent uptake of proteins
C6Y53_RS03215	COG0848	biopolymer transport protein
C6Y53_RS03225	COG0824	Thioesterase
C6Y53_RS03235	COG2255	four-way junction helicase activity
C6Y53_RS03240	COG0632	four-way junction helicase activity
C6Y53_RS03245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C6Y53_RS03260	COG0395	ABC-type sugar transport system, permease component
C6Y53_RS03265	COG1175	transmembrane transport
C6Y53_RS03270	COG3842	ATPase activity
C6Y53_RS03275	COG3842	ATPase activity
C6Y53_RS03295	COG1136	(ABC) transporter
C6Y53_RS03335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6Y53_RS03340	COG0242	peptide deformylase activity
C6Y53_RS03345	COG0242	peptide deformylase activity
C6Y53_RS03350	COG0242	peptide deformylase activity
C6Y53_RS03355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C6Y53_RS03365	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C6Y53_RS03385	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C6Y53_RS03390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C6Y53_RS03400	COG0356	it plays a direct role in the translocation of protons across the membrane
C6Y53_RS03435	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C6Y53_RS03440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C6Y53_RS03465	COG0228	four-way junction DNA binding
C6Y53_RS03470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C6Y53_RS03480	COG0336	Belongs to the RNA methyltransferase TrmD family
C6Y53_RS03490	COG0335	large ribosomal subunit rRNA binding
C6Y53_RS03495	COG0254	rRNA binding
C6Y53_RS03500	COG2151	metal-sulfur cluster biosynthetic enzyme
C6Y53_RS03500	COG0489	protein tyrosine kinase activity
C6Y53_RS03515	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C6Y53_RS03540	COG0625	glutathione transferase activity
C6Y53_RS03545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6Y53_RS03560	COG0284	orotidine-5'-phosphate decarboxylase activity
C6Y53_RS03565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6Y53_RS03580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C6Y53_RS03585	COG1840	ABC-type Fe3 transport system, periplasmic component
C6Y53_RS03590	COG1227	inorganic diphosphatase activity
C6Y53_RS03600	COG2030	dehydratase
C6Y53_RS03605	COG0196	riboflavin kinase activity
C6Y53_RS03610	COG2983	Belongs to the UPF0260 family
C6Y53_RS03640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C6Y53_RS03645	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C6Y53_RS03650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C6Y53_RS03655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C6Y53_RS03660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6Y53_RS03670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6Y53_RS03695	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C6Y53_RS03715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6Y53_RS03735	COG0287	Prephenate dehydrogenase
C6Y53_RS03740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6Y53_RS03745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C6Y53_RS03750	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C6Y53_RS03760	COG1522	sequence-specific DNA binding
C6Y53_RS03775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6Y53_RS03780	COG0251	oxidation-reduction process
C6Y53_RS03800	COG3246	L-lysine catabolic process to acetate
C6Y53_RS03805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6Y53_RS03810	COG3842	ATPase activity
C6Y53_RS03825	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6Y53_RS03830	COG0583	DNA-binding transcription factor activity
C6Y53_RS03835	COG4608	Belongs to the ABC transporter superfamily
C6Y53_RS03850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS03860	COG2197	response regulator
C6Y53_RS03875	COG1388	LysM domain
C6Y53_RS03875	COG1376	ErfK ybiS ycfS ynhG family protein
C6Y53_RS03895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6Y53_RS03900	COG1473	amidohydrolase
C6Y53_RS03905	COG4172	Belongs to the ABC transporter superfamily
C6Y53_RS03910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS03915	COG0601	transmembrane transport
C6Y53_RS03945	COG0642	Histidine kinase
C6Y53_RS03975	COG2095	MarC family integral membrane protein
C6Y53_RS03980	COG0752	glycyl-tRNA synthetase alpha subunit
C6Y53_RS03990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C6Y53_RS04005	COG1469	GTP cyclohydrolase I activity
C6Y53_RS04020	COG2917	probably involved in intracellular septation
C6Y53_RS04030	COG0552	protein localization to endoplasmic reticulum
C6Y53_RS04055	COG1570	exodeoxyribonuclease VII activity
C6Y53_RS04060	COG0151	Belongs to the GarS family
C6Y53_RS04090	COG0330	HflC and HflK could
C6Y53_RS04095	COG0330	HflC and HflK could
C6Y53_RS04105	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C6Y53_RS04110	COG1760	l-serine dehydratase
C6Y53_RS04135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C6Y53_RS04160	COG1846	Transcriptional regulator
C6Y53_RS04185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C6Y53_RS04190	COG0793	Belongs to the peptidase S41A family
C6Y53_RS04195	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C6Y53_RS04205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6Y53_RS04205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6Y53_RS04210	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C6Y53_RS04215	COG0330	HflC and HflK could
C6Y53_RS04240	COG2151	metal-sulfur cluster biosynthetic enzyme
C6Y53_RS04245	COG0316	Belongs to the HesB IscA family
C6Y53_RS04250	COG0149	triose-phosphate isomerase activity
C6Y53_RS04255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6Y53_RS04260	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C6Y53_RS04265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6Y53_RS04280	COG1522	sequence-specific DNA binding
C6Y53_RS04285	COG1648	precorrin-2 dehydrogenase activity
C6Y53_RS04285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C6Y53_RS04295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6Y53_RS04300	COG0175	sulfate reduction
C6Y53_RS04320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C6Y53_RS04330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C6Y53_RS04465	COG2390	Transcriptional regulator
C6Y53_RS04470	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C6Y53_RS04480	COG1129	ABC transporter
C6Y53_RS04485	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6Y53_RS04505	COG4176	ABC-type proline glycine betaine transport system permease component
C6Y53_RS04510	COG3448	diguanylate cyclase activity
C6Y53_RS04510	COG4175	Glycine betaine
C6Y53_RS04540	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y53_RS04540	COG0824	Thioesterase
C6Y53_RS04550	COG3246	L-lysine catabolic process to acetate
C6Y53_RS04555	COG0667	Aldo Keto reductase
C6Y53_RS04565	COG2353	YceI-like domain
C6Y53_RS04575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6Y53_RS04600	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C6Y53_RS04615	COG0542	response to heat
C6Y53_RS04625	COG0418	dihydroorotase activity
C6Y53_RS04645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6Y53_RS04650	COG1127	ABC transporter
C6Y53_RS04695	COG0400	carboxylic ester hydrolase activity
C6Y53_RS04705	COG2814	Major facilitator Superfamily
C6Y53_RS04715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6Y53_RS04720	COG0215	cysteine-tRNA ligase activity
C6Y53_RS04725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C6Y53_RS04735	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS04740	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C6Y53_RS04745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C6Y53_RS04765	COG3842	ATPase activity
C6Y53_RS04780	COG2378	regulation of single-species biofilm formation
C6Y53_RS04785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6Y53_RS04790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6Y53_RS04795	COG0805	protein transport
C6Y53_RS04800	COG4335	DNA alkylation repair
C6Y53_RS04805	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS04810	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C6Y53_RS04820	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C6Y53_RS04875	COG2264	protein methyltransferase activity
C6Y53_RS04885	COG0028	Belongs to the TPP enzyme family
C6Y53_RS04890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6Y53_RS04915	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C6Y53_RS04925	COG0556	nucleotide-excision repair
C6Y53_RS04930	COG0569	domain protein
C6Y53_RS04935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C6Y53_RS04975	COG0683	leucine binding
C6Y53_RS05000	COG1960	acyl-CoA dehydrogenase activity
C6Y53_RS05005	COG1024	Enoyl-CoA hydratase
C6Y53_RS05015	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS05035	COG0582	viral genome integration into host DNA
C6Y53_RS05040	COG3328	transposase activity
C6Y53_RS05075	COG0785	Cytochrome C biogenesis protein
C6Y53_RS05100	COG3258	Cytochrome c
C6Y53_RS05105	COG0737	Belongs to the 5'-nucleotidase family
C6Y53_RS05115	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C6Y53_RS05130	COG2391	methyltransferase activity
C6Y53_RS05150	COG0523	cobalamin synthesis protein
C6Y53_RS05155	COG1228	amidohydrolase
C6Y53_RS05170	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y53_RS05180	COG0583	DNA-binding transcription factor activity
C6Y53_RS05205	COG4336	lyase activity
C6Y53_RS05230	COG1309	transcriptional regulator
C6Y53_RS05250	COG0596	Alpha beta hydrolase
C6Y53_RS05255	COG1674	ftsk spoiiie
C6Y53_RS05260	COG0436	Aminotransferase
C6Y53_RS05270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6Y53_RS05280	COG1185	polyribonucleotide nucleotidyltransferase activity
C6Y53_RS05290	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C6Y53_RS05305	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C6Y53_RS05310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C6Y53_RS05325	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C6Y53_RS05335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C6Y53_RS05355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C6Y53_RS05360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C6Y53_RS05385	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C6Y53_RS05410	COG0713	ATP synthesis coupled electron transport
C6Y53_RS05425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6Y53_RS05435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C6Y53_RS05480	COG0649	NAD binding
C6Y53_RS05485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6Y53_RS05490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6Y53_RS05500	COG1024	Enoyl-CoA hydratase
C6Y53_RS05515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6Y53_RS05525	COG1960	acyl-CoA dehydrogenase activity
C6Y53_RS05535	COG0546	phosphoglycolate phosphatase activity
C6Y53_RS05540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6Y53_RS05555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C6Y53_RS05560	COG1519	Transferase
C6Y53_RS05565	COG0438	transferase activity, transferring glycosyl groups
C6Y53_RS05570	COG1473	amidohydrolase
C6Y53_RS05575	COG1473	amidohydrolase
C6Y53_RS05585	COG4172	Belongs to the ABC transporter superfamily
C6Y53_RS05595	COG0601	transmembrane transport
C6Y53_RS05600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS05630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C6Y53_RS05640	COG0288	reversible hydration of carbon dioxide
C6Y53_RS05650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C6Y53_RS05655	COG0791	NLP P60 protein
C6Y53_RS05665	COG2050	protein possibly involved in aromatic compounds catabolism
C6Y53_RS05670	COG0183	Belongs to the thiolase family
C6Y53_RS05690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C6Y53_RS05715	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C6Y53_RS05720	COG1671	Belongs to the UPF0178 family
C6Y53_RS05730	COG2423	ornithine cyclodeaminase activity
C6Y53_RS05740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C6Y53_RS05745	COG0285	dihydrofolate synthase activity
C6Y53_RS05750	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C6Y53_RS05765	COG0129	dihydroxy-acid dehydratase activity
C6Y53_RS05775	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C6Y53_RS05795	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y53_RS05805	COG0028	Belongs to the TPP enzyme family
C6Y53_RS05805	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
C6Y53_RS05825	COG0826	peptidase U32
C6Y53_RS05840	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C6Y53_RS05860	COG1183	phosphatidylcholine synthase activity
C6Y53_RS05895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C6Y53_RS05895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C6Y53_RS05920	COG0457	Tetratricopeptide repeat
C6Y53_RS05935	COG0006	proline dipeptidase activity
C6Y53_RS05950	COG3842	ATPase activity
C6Y53_RS05970	COG1234	tRNA 3'-trailer cleavage
C6Y53_RS05975	COG0084	hydrolase, TatD family'
C6Y53_RS05985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6Y53_RS06065	COG1473	amidohydrolase
C6Y53_RS06095	COG4771	TonB-dependent receptor
C6Y53_RS06105	COG1132	(ABC) transporter
C6Y53_RS06125	COG3547	Transposase (IS116 IS110 IS902 family)
C6Y53_RS06145	COG3845	ABC transporter
C6Y53_RS06150	COG4603	Belongs to the binding-protein-dependent transport system permease family
C6Y53_RS06155	COG1079	Belongs to the binding-protein-dependent transport system permease family
C6Y53_RS06165	COG2963	transposase activity
C6Y53_RS06175	COG3668	Plasmid stabilization system
C6Y53_RS06190	COG0697	spore germination
C6Y53_RS06205	COG1216	Glycosyl transferase, family 2
C6Y53_RS06225	COG1304	FMN binding
C6Y53_RS06230	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C6Y53_RS06245	COG0131	Imidazoleglycerol-phosphate dehydratase
C6Y53_RS06250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C6Y53_RS06265	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C6Y53_RS06275	COG0107	imidazoleglycerol-phosphate synthase activity
C6Y53_RS06280	COG0140	phosphoribosyl-ATP diphosphatase activity
C6Y53_RS06285	COG1832	CoA-binding protein
C6Y53_RS06300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6Y53_RS06325	COG1475	DNA binding
C6Y53_RS06405	COG3750	Belongs to the UPF0335 family
C6Y53_RS06580	COG3239	Fatty acid desaturase
C6Y53_RS06585	COG1194	a g-specific adenine glycosylase
C6Y53_RS06605	COG1663	tetraacyldisaccharide 4'-kinase activity
C6Y53_RS06625	COG0312	modulator of DNA gyrase
C6Y53_RS06640	COG1024	Enoyl-CoA hydratase
C6Y53_RS06650	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6Y53_RS06655	COG0567	Dehydrogenase, E1 component
C6Y53_RS06660	COG3152	Membrane
C6Y53_RS06685	COG0045	succinate-CoA ligase (ADP-forming) activity
C6Y53_RS06700	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C6Y53_RS06705	COG0811	peptide transport
C6Y53_RS06725	COG0589	response to stress
C6Y53_RS06730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6Y53_RS06730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C6Y53_RS06750	COG0583	DNA-binding transcription factor activity
C6Y53_RS06760	COG0436	Aminotransferase
C6Y53_RS06765	COG0022	dehydrogenase e1 component
C6Y53_RS06775	COG1012	belongs to the aldehyde dehydrogenase family
C6Y53_RS06790	COG2391	methyltransferase activity
C6Y53_RS06855	COG3267	Type II secretory pathway component ExeA
C6Y53_RS06855	COG3409	Peptidoglycan-binding domain 1 protein
C6Y53_RS06875	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C6Y53_RS06880	COG3639	organic phosphonate transmembrane transporter activity
C6Y53_RS06915	COG4948	Mandelate Racemase Muconate Lactonizing
C6Y53_RS06945	COG0469	pyruvate kinase activity
C6Y53_RS06955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C6Y53_RS06960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C6Y53_RS06975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C6Y53_RS06985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6Y53_RS06985	COG0072	phenylalanine-tRNA ligase activity
C6Y53_RS07000	COG3246	L-lysine catabolic process to acetate
C6Y53_RS07005	COG0583	DNA-binding transcription factor activity
C6Y53_RS07010	COG4948	Mandelate Racemase Muconate Lactonizing
C6Y53_RS07015	COG3485	protocatechuate 3,4-dioxygenase
C6Y53_RS07025	COG0196	riboflavin kinase activity
C6Y53_RS07035	COG0668	transmembrane transport
C6Y53_RS07040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C6Y53_RS07045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C6Y53_RS07055	COG2321	neutral zinc metallopeptidase
C6Y53_RS07100	COG0405	Gamma-glutamyltransferase
C6Y53_RS07105	COG4608	Belongs to the ABC transporter superfamily
C6Y53_RS07110	COG0444	Belongs to the ABC transporter superfamily
C6Y53_RS07115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS07120	COG0601	transmembrane transport
C6Y53_RS07125	COG0747	negative chemotaxis
C6Y53_RS07135	COG0641	radical SAM
C6Y53_RS07145	COG1126	abc transporter atp-binding protein
C6Y53_RS07150	COG0765	amino acid transport
C6Y53_RS07155	COG4597	amino acid ABC transporter
C6Y53_RS07160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y53_RS07175	COG0668	transmembrane transport
C6Y53_RS07180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6Y53_RS07205	COG0747	negative chemotaxis
C6Y53_RS07210	COG0601	transmembrane transport
C6Y53_RS07215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS07230	COG0154	amidase activity
C6Y53_RS07255	COG1070	Carbohydrate kinase
C6Y53_RS07265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C6Y53_RS07270	COG0667	Aldo Keto reductase
C6Y53_RS07280	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6Y53_RS07285	COG1129	ABC transporter
C6Y53_RS07305	COG2226	methyltransferase
C6Y53_RS07310	COG0076	glutamate decarboxylase activity
C6Y53_RS07335	COG1595	DNA-templated transcription, initiation
C6Y53_RS07340	COG2186	Transcriptional regulator
C6Y53_RS07345	COG0747	negative chemotaxis
C6Y53_RS07350	COG0601	transmembrane transport
C6Y53_RS07355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS07370	COG0444	Belongs to the ABC transporter superfamily
C6Y53_RS07375	COG4608	Belongs to the ABC transporter superfamily
C6Y53_RS07395	COG0590	tRNA wobble adenosine to inosine editing
C6Y53_RS07400	COG2807	transmembrane transport
C6Y53_RS07405	COG0666	response to abiotic stimulus
C6Y53_RS07415	COG4566	intracellular signal transduction
C6Y53_RS07420	COG4191	Histidine kinase
C6Y53_RS07545	COG3328	transposase activity
C6Y53_RS07570	COG3550	peptidyl-serine autophosphorylation
C6Y53_RS07625	COG1846	Transcriptional regulator
C6Y53_RS07660	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C6Y53_RS07665	COG0183	Belongs to the thiolase family
C6Y53_RS07670	COG1396	sequence-specific DNA binding
C6Y53_RS07675	COG0156	8-amino-7-oxononanoate synthase activity
C6Y53_RS07680	COG1063	alcohol dehydrogenase
C6Y53_RS07690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C6Y53_RS07695	COG0784	Response regulator, receiver
C6Y53_RS07695	COG5002	protein histidine kinase activity
C6Y53_RS07700	COG1335	isochorismatase
C6Y53_RS07705	COG1054	Belongs to the UPF0176 family
C6Y53_RS07710	COG2271	Major facilitator Superfamily
C6Y53_RS07735	COG1192	Involved in chromosome partitioning
C6Y53_RS07750	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C6Y53_RS07760	COG2027	D-alanyl-D-alanine carboxypeptidase
C6Y53_RS07770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C6Y53_RS07785	COG0488	(ABC) transporter
C6Y53_RS07790	COG1943	Transposase
C6Y53_RS07800	COG1278	Cold shock
C6Y53_RS07805	COG1376	ErfK ybiS ycfS ynhG family protein
C6Y53_RS07815	COG4181	ATPase activity
C6Y53_RS07825	COG1959	2 iron, 2 sulfur cluster binding
C6Y53_RS07835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6Y53_RS07860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6Y53_RS07885	COG0772	Belongs to the SEDS family
C6Y53_RS07890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6Y53_RS07900	COG0339	signal peptide processing
C6Y53_RS07905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C6Y53_RS07910	COG0756	dUTP diphosphatase activity
C6Y53_RS07945	COG1012	belongs to the aldehyde dehydrogenase family
C6Y53_RS07955	COG0235	Class ii aldolase
C6Y53_RS07960	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6Y53_RS07965	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS07970	COG2721	sulfolactate sulfo-lyase activity
C6Y53_RS07975	COG2186	Transcriptional regulator
C6Y53_RS07980	COG3618	amidohydrolase
C6Y53_RS08000	COG1070	Carbohydrate kinase
C6Y53_RS08025	COG0019	diaminopimelate decarboxylase activity
C6Y53_RS08040	COG0165	Argininosuccinate lyase
C6Y53_RS08045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6Y53_RS08050	COG0668	transmembrane transport
C6Y53_RS08105	COG1960	acyl-CoA dehydrogenase activity
C6Y53_RS08110	COG1960	acyl-CoA dehydrogenase activity
C6Y53_RS08115	COG1024	Enoyl-CoA hydratase
C6Y53_RS08115	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y53_RS08135	COG2885	chlorophyll binding
C6Y53_RS08140	COG2815	serine threonine protein kinase
C6Y53_RS08140	COG0515	serine threonine protein kinase
C6Y53_RS08145	COG0631	protein serine/threonine phosphatase activity
C6Y53_RS08290	COG2818	Glycosylase
C6Y53_RS08305	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS08330	COG0142	geranyltranstransferase activity
C6Y53_RS08335	COG1968	undecaprenyl-diphosphatase activity
C6Y53_RS08365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6Y53_RS08380	COG2226	methyltransferase
C6Y53_RS08385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6Y53_RS08395	COG0268	Binds directly to 16S ribosomal RNA
C6Y53_RS08400	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6Y53_RS08410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6Y53_RS08415	COG1280	lysine exporter protein (LysE YggA)
C6Y53_RS08465	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C6Y53_RS08470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C6Y53_RS08485	COG4172	Belongs to the ABC transporter superfamily
C6Y53_RS08490	COG4239	(ABC) transporter, permease
C6Y53_RS08495	COG4174	ABC transporter (Permease)
C6Y53_RS08500	COG4166	transmembrane transport
C6Y53_RS08510	COG0077	Prephenate dehydratase
C6Y53_RS08520	COG2816	NAD+ diphosphatase activity
C6Y53_RS08525	COG0737	Belongs to the 5'-nucleotidase family
C6Y53_RS08535	COG1178	ABC-type Fe3 transport system permease component
C6Y53_RS08540	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C6Y53_RS08580	COG0745	RESPONSE REGULATOR receiver
C6Y53_RS08600	COG3383	formate dehydrogenase (NAD+) activity
C6Y53_RS08625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C6Y53_RS08630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C6Y53_RS08635	COG1012	belongs to the aldehyde dehydrogenase family
C6Y53_RS08640	COG0612	Peptidase, M16
C6Y53_RS08645	COG0612	Peptidase, M16
C6Y53_RS08655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C6Y53_RS08665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C6Y53_RS08685	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C6Y53_RS08690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C6Y53_RS08700	COG0405	Gamma-glutamyltransferase
C6Y53_RS08740	COG2962	Rard protein
C6Y53_RS08750	COG0564	pseudouridine synthase activity
C6Y53_RS08770	COG0450	alkyl hydroperoxide reductase
C6Y53_RS08780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6Y53_RS08790	COG3842	ATPase activity
C6Y53_RS08800	COG1175	transmembrane transport
C6Y53_RS08805	COG0395	ABC-type sugar transport system, permease component
C6Y53_RS08810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C6Y53_RS08815	COG1086	Polysaccharide biosynthesis protein
C6Y53_RS08855	COG1609	Transcriptional regulator
C6Y53_RS08860	COG3214	Protein conserved in bacteria
C6Y53_RS08875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6Y53_RS08880	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6Y53_RS08890	COG0601	transmembrane transport
C6Y53_RS08895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS08905	COG4172	Belongs to the ABC transporter superfamily
C6Y53_RS08920	COG2733	membrane
C6Y53_RS08985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6Y53_RS08995	COG0071	Belongs to the small heat shock protein (HSP20) family
C6Y53_RS09005	COG0247	lactate metabolic process
C6Y53_RS09010	COG0277	FAD linked oxidase domain protein
C6Y53_RS09015	COG0277	FAD linked oxidase domain protein
C6Y53_RS09025	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C6Y53_RS09030	COG0799	negative regulation of ribosome biogenesis
C6Y53_RS09035	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C6Y53_RS09035	COG3264	Mechanosensitive ion channel
C6Y53_RS09045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C6Y53_RS09055	COG0066	3-isopropylmalate dehydratase activity
C6Y53_RS09065	COG0473	3-isopropylmalate dehydrogenase activity
C6Y53_RS09080	COG3030	protein affecting phage T7 exclusion by the F plasmid
C6Y53_RS09085	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C6Y53_RS09090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6Y53_RS09095	COG0237	dephospho-CoA kinase activity
C6Y53_RS09100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6Y53_RS09105	COG0424	maF-like protein
C6Y53_RS09110	COG1981	membrane
C6Y53_RS09115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C6Y53_RS09120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C6Y53_RS09125	COG0445	tRNA wobble uridine modification
C6Y53_RS09130	COG0357	Ribosomal RNA small subunit methyltransferase G
C6Y53_RS09145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C6Y53_RS09150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C6Y53_RS09155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C6Y53_RS09160	COG1420	regulation of RNA biosynthetic process
C6Y53_RS09165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C6Y53_RS09170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C6Y53_RS09175	COG0280	phosphate acetyltransferase
C6Y53_RS09175	COG0281	malic enzyme
C6Y53_RS09185	COG0137	argininosuccinate synthase activity
C6Y53_RS09190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6Y53_RS09210	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C6Y53_RS09215	COG0494	nUDIX hydrolase
C6Y53_RS09220	COG0617	tRNA 3'-terminal CCA addition
C6Y53_RS09225	COG1132	(ABC) transporter
C6Y53_RS09230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6Y53_RS09240	COG3034	peptidoglycan biosynthetic process
C6Y53_RS09280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6Y53_RS09290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C6Y53_RS09305	COG0779	Required for maturation of 30S ribosomal subunits
C6Y53_RS09320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C6Y53_RS09325	COG0494	nUDIX hydrolase
C6Y53_RS09330	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C6Y53_RS09335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6Y53_RS09340	COG0653	protein targeting
C6Y53_RS09345	COG1960	acyl-CoA dehydrogenase activity
C6Y53_RS09350	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C6Y53_RS09355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C6Y53_RS09355	COG0517	IMP dehydrogenase activity
C6Y53_RS09370	COG1137	ATPase activity
C6Y53_RS09375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C6Y53_RS09380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6Y53_RS09405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C6Y53_RS09420	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C6Y53_RS09445	COG0443	Heat shock 70 kDa protein
C6Y53_RS09450	COG0484	heat shock protein binding
C6Y53_RS09455	COG2003	Belongs to the UPF0758 family
C6Y53_RS09460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C6Y53_RS09465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6Y53_RS09495	COG2010	Cytochrome c
C6Y53_RS09525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y53_RS09610	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C6Y53_RS09625	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C6Y53_RS09625	COG0778	Nitroreductase
C6Y53_RS09635	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C6Y53_RS09640	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C6Y53_RS09645	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C6Y53_RS09690	COG4178	(ABC) transporter
C6Y53_RS09695	COG4771	TonB-dependent receptor
C6Y53_RS09755	COG1116	anion transmembrane transporter activity
C6Y53_RS09805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS09810	COG0444	Belongs to the ABC transporter superfamily
C6Y53_RS09820	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C6Y53_RS09830	COG1960	acyl-CoA dehydrogenase activity
C6Y53_RS09835	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y53_RS09840	COG1960	acyl-CoA dehydrogenase activity
C6Y53_RS09875	COG1309	transcriptional regulator
C6Y53_RS09880	COG0183	Belongs to the thiolase family
C6Y53_RS09890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6Y53_RS09895	COG3707	response regulator
C6Y53_RS09900	COG1116	anion transmembrane transporter activity
C6Y53_RS09900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y53_RS09905	COG1116	anion transmembrane transporter activity
C6Y53_RS09905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y53_RS09910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y53_RS09915	COG1116	anion transmembrane transporter activity
C6Y53_RS09915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y53_RS09920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6Y53_RS09925	COG2146	nitrite reductase [NAD(P)H] activity
C6Y53_RS09930	COG0243	molybdopterin cofactor binding
C6Y53_RS09950	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C6Y53_RS09955	COG0181	hydroxymethylbilane synthase activity
C6Y53_RS09965	COG0573	inorganic phosphate transmembrane transporter activity
C6Y53_RS09970	COG0581	inorganic phosphate transmembrane transporter activity
C6Y53_RS09975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6Y53_RS09985	COG0745	RESPONSE REGULATOR receiver
C6Y53_RS09990	COG0408	coproporphyrinogen oxidase activity
C6Y53_RS10000	COG2813	Specifically methylates the guanine in position
C6Y53_RS10005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C6Y53_RS10015	COG1686	Belongs to the peptidase S11 family
C6Y53_RS10020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6Y53_RS10025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C6Y53_RS10030	COG3408	Glycogen debranching enzyme
C6Y53_RS10030	COG3119	arylsulfatase activity
C6Y53_RS10115	COG0587	DNA-directed DNA polymerase activity
C6Y53_RS10155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C6Y53_RS10160	COG2226	methyltransferase
C6Y53_RS10170	COG1522	sequence-specific DNA binding
C6Y53_RS10175	COG0686	Belongs to the AlaDH PNT family
C6Y53_RS10185	COG0395	ABC-type sugar transport system, permease component
C6Y53_RS10195	COG1653	transport
C6Y53_RS10200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C6Y53_RS10205	COG0594	ribonuclease P activity
C6Y53_RS10210	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C6Y53_RS10215	COG4191	Histidine kinase
C6Y53_RS10225	COG0039	L-malate dehydrogenase activity
C6Y53_RS10255	COG2030	dehydratase
C6Y53_RS10300	COG0180	Tryptophanyl-tRNA synthetase
C6Y53_RS10310	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C6Y53_RS10315	COG0049	tRNA binding
C6Y53_RS10320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C6Y53_RS10325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6Y53_RS10330	COG0051	transcription antitermination factor activity, RNA binding
C6Y53_RS10335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C6Y53_RS10340	COG0088	Forms part of the polypeptide exit tunnel
C6Y53_RS10345	COG0089	rRNA binding
C6Y53_RS10350	COG1858	cytochrome C peroxidase
C6Y53_RS10355	COG0659	secondary active sulfate transmembrane transporter activity
C6Y53_RS10360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C6Y53_RS10365	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C6Y53_RS10370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C6Y53_RS10375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C6Y53_RS10380	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C6Y53_RS10390	COG0255	Belongs to the universal ribosomal protein uL29 family
C6Y53_RS10395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C6Y53_RS10400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C6Y53_RS10405	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C6Y53_RS10410	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C6Y53_RS10415	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C6Y53_RS10420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C6Y53_RS10425	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C6Y53_RS10430	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C6Y53_RS10435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C6Y53_RS10440	COG1841	ribosomal large subunit assembly
C6Y53_RS10445	COG0200	Binds to the 23S rRNA
C6Y53_RS10450	COG0201	protein transport
C6Y53_RS10455	COG0563	adenylate kinase activity
C6Y53_RS10460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C6Y53_RS10465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C6Y53_RS10470	COG0202	RNA polymerase activity
C6Y53_RS10475	COG0203	ribosomal protein L17
C6Y53_RS10480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6Y53_RS10485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C6Y53_RS10490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6Y53_RS10495	COG0564	pseudouridine synthase activity
C6Y53_RS10500	COG0546	phosphoglycolate phosphatase activity
C6Y53_RS10510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y53_RS10515	COG4597	amino acid ABC transporter
C6Y53_RS10520	COG0765	amino acid transport
C6Y53_RS10525	COG1126	abc transporter atp-binding protein
C6Y53_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS10545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6Y53_RS10565	COG0604	alcohol dehydrogenase
C6Y53_RS10570	COG2937	Belongs to the GPAT DAPAT family
C6Y53_RS10575	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6Y53_RS10575	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6Y53_RS10580	COG2916	Histone family protein nucleoid-structuring protein H-NS
C6Y53_RS10585	COG0813	purine-nucleoside phosphorylase activity
C6Y53_RS10595	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C6Y53_RS10605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C6Y53_RS10610	COG0792	nuclease activity
C6Y53_RS10620	COG0606	chelatase, subunit chli
C6Y53_RS10625	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6Y53_RS10630	COG0250	Participates in transcription elongation, termination and antitermination
C6Y53_RS10635	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C6Y53_RS10640	COG0081	regulation of translation
C6Y53_RS10645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C6Y53_RS10650	COG0222	ribosome binding
C6Y53_RS10655	COG0085	RNA polymerase activity
C6Y53_RS10660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C6Y53_RS10670	COG0697	spore germination
C6Y53_RS10675	COG0800	Aldolase
C6Y53_RS10680	COG0129	dihydroxy-acid dehydratase activity
C6Y53_RS10685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y53_RS10700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS10705	COG0601	transmembrane transport
C6Y53_RS10715	COG4172	Belongs to the ABC transporter superfamily
C6Y53_RS10730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C6Y53_RS10735	COG0625	glutathione transferase activity
C6Y53_RS10745	COG4988	ABC transporter
C6Y53_RS10755	COG4948	Mandelate Racemase Muconate Lactonizing
C6Y53_RS10775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6Y53_RS10790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C6Y53_RS10795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6Y53_RS10800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C6Y53_RS10805	COG0735	belongs to the Fur family
C6Y53_RS10825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6Y53_RS10840	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C6Y53_RS10845	COG4535	Mg2 and Co2 transporter CorC
C6Y53_RS10850	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C6Y53_RS10855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C6Y53_RS10860	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C6Y53_RS10865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6Y53_RS10870	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C6Y53_RS10885	COG2186	Transcriptional regulator
C6Y53_RS10935	COG3971	2-oxopent-4-enoate hydratase activity
C6Y53_RS10960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6Y53_RS10965	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y53_RS10970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6Y53_RS10980	COG1802	Transcriptional regulator
C6Y53_RS10985	COG0114	fumarate hydratase activity
C6Y53_RS11020	COG2186	Transcriptional regulator
C6Y53_RS11040	COG0604	alcohol dehydrogenase
C6Y53_RS11050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C6Y53_RS11055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C6Y53_RS11060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6Y53_RS11070	COG0494	nUDIX hydrolase
C6Y53_RS11080	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C6Y53_RS11080	COG3264	Mechanosensitive ion channel
C6Y53_RS11140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6Y53_RS11150	COG1475	DNA binding
C6Y53_RS11185	COG1177	transmembrane transport
C6Y53_RS11205	COG1802	Transcriptional regulator
C6Y53_RS11210	COG3959	Transketolase, thiamine diphosphate binding domain
C6Y53_RS11215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C6Y53_RS11230	COG0601	transmembrane transport
C6Y53_RS11235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS11240	COG0444	Belongs to the ABC transporter superfamily
C6Y53_RS11275	COG3119	arylsulfatase activity
C6Y53_RS11285	COG3901	Regulator of nitric oxide reductase transcription
C6Y53_RS11285	COG0348	domain, Protein
C6Y53_RS11320	COG1131	(ABC) transporter
C6Y53_RS11350	COG2205	protein histidine kinase activity
C6Y53_RS11360	COG1012	belongs to the aldehyde dehydrogenase family
C6Y53_RS11365	COG0535	radical SAM domain protein
C6Y53_RS11370	COG0535	radical SAM domain protein
C6Y53_RS11375	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C6Y53_RS11380	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C6Y53_RS11400	COG1012	belongs to the aldehyde dehydrogenase family
C6Y53_RS11415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y53_RS11420	COG0842	Transport permease protein
C6Y53_RS11420	COG1129	ABC transporter
C6Y53_RS11425	COG0842	Transport permease protein
C6Y53_RS11435	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6Y53_RS11520	COG0747	negative chemotaxis
C6Y53_RS11525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS11530	COG0601	transmembrane transport
C6Y53_RS11540	COG4608	Belongs to the ABC transporter superfamily
C6Y53_RS11545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C6Y53_RS11550	COG1522	sequence-specific DNA binding
C6Y53_RS11565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS11570	COG0601	transmembrane transport
C6Y53_RS11575	COG0747	negative chemotaxis
C6Y53_RS11580	COG4608	Belongs to the ABC transporter superfamily
C6Y53_RS11590	COG0444	Belongs to the ABC transporter superfamily
C6Y53_RS11595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS11600	COG0601	transmembrane transport
C6Y53_RS11605	COG4166	transmembrane transport
C6Y53_RS11615	COG3958	Transketolase
C6Y53_RS11620	COG3959	Transketolase, thiamine diphosphate binding domain
C6Y53_RS11625	COG1802	Transcriptional regulator
C6Y53_RS11630	COG0154	amidase activity
C6Y53_RS11655	COG0747	negative chemotaxis
C6Y53_RS11705	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C6Y53_RS11710	COG4143	(ABC) transporter
C6Y53_RS11720	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C6Y53_RS11725	COG0625	glutathione transferase activity
C6Y53_RS11760	COG0348	domain, Protein
C6Y53_RS11770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C6Y53_RS11795	COG0625	glutathione transferase activity
C6Y53_RS11810	COG0495	leucyl-tRNA aminoacylation
C6Y53_RS11825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C6Y53_RS11840	COG0745	RESPONSE REGULATOR receiver
C6Y53_RS11850	COG0730	response to heat
C6Y53_RS11855	COG1079	Belongs to the binding-protein-dependent transport system permease family
C6Y53_RS11860	COG4603	Belongs to the binding-protein-dependent transport system permease family
C6Y53_RS11865	COG3845	ABC transporter
C6Y53_RS11870	COG1744	ABC transporter substrate-binding protein PnrA-like
C6Y53_RS11880	COG1214	PFAM Peptidase M22, glycoprotease
C6Y53_RS11885	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C6Y53_RS11920	COG2835	tetraacyldisaccharide 4'-kinase activity
C6Y53_RS11930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C6Y53_RS11935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C6Y53_RS11945	COG0706	membrane insertase activity
C6Y53_RS11955	COG0037	tRNA processing
C6Y53_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS11980	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C6Y53_RS11985	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C6Y53_RS11995	COG1131	(ABC) transporter
C6Y53_RS12000	COG0842	Transport permease protein
C6Y53_RS12005	COG0616	signal peptide processing
C6Y53_RS12005	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C6Y53_RS12020	COG0322	excinuclease ABC activity
C6Y53_RS12025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6Y53_RS12035	COG0314	molybdopterin synthase activity
C6Y53_RS12045	COG2885	chlorophyll binding
C6Y53_RS12045	COG3047	cAMP biosynthetic process
C6Y53_RS12050	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C6Y53_RS12055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C6Y53_RS12105	COG0747	negative chemotaxis
C6Y53_RS12110	COG0601	transmembrane transport
C6Y53_RS12115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS12120	COG0444	Belongs to the ABC transporter superfamily
C6Y53_RS12125	COG4608	Belongs to the ABC transporter superfamily
C6Y53_RS12130	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C6Y53_RS12135	COG0697	spore germination
C6Y53_RS12140	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C6Y53_RS12145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6Y53_RS12155	COG0540	Belongs to the ATCase OTCase family
C6Y53_RS12165	COG1573	uracil-dna glycosylase
C6Y53_RS12180	COG0521	Mo-molybdopterin cofactor biosynthetic process
C6Y53_RS12195	COG0494	nUDIX hydrolase
C6Y53_RS12205	COG1678	Uncharacterized ACR, COG1678
C6Y53_RS12210	COG0009	L-threonylcarbamoyladenylate synthase
C6Y53_RS12215	COG1960	acyl-CoA dehydrogenase activity
C6Y53_RS12230	COG0584	glycerophosphoryl diester phosphodiesterase
C6Y53_RS12265	COG0746	molybdenum cofactor guanylyltransferase activity
C6Y53_RS12275	COG0303	'Molybdopterin
C6Y53_RS12290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6Y53_RS12295	COG2860	membrane
C6Y53_RS12300	COG0328	RNA-DNA hybrid ribonuclease activity
C6Y53_RS12310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C6Y53_RS12330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C6Y53_RS12335	COG1758	RNA polymerase activity
C6Y53_RS12350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C6Y53_RS12360	COG0736	holo-[acyl-carrier-protein] synthase activity
C6Y53_RS12365	COG0681	Belongs to the peptidase S26 family
C6Y53_RS12370	COG0571	ribonuclease III activity
C6Y53_RS12375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6Y53_RS12380	COG1757	Na H antiporter
C6Y53_RS12385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C6Y53_RS12395	COG1381	Involved in DNA repair and RecF pathway recombination
C6Y53_RS12420	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C6Y53_RS12425	COG0745	RESPONSE REGULATOR receiver
C6Y53_RS12430	COG2205	protein histidine kinase activity
C6Y53_RS12440	COG1660	Displays ATPase and GTPase activities
C6Y53_RS12460	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y53_RS12480	COG2096	Adenosyltransferase
C6Y53_RS12490	COG0300	oxidoreductase activity
C6Y53_RS12500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6Y53_RS12510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6Y53_RS12550	COG2358	TRAP transporter, solute receptor (TAXI family
C6Y53_RS12555	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C6Y53_RS12560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y53_RS12565	COG1802	Transcriptional regulator
C6Y53_RS12570	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C6Y53_RS12625	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C6Y53_RS12635	COG1304	FMN binding
C6Y53_RS12640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6Y53_RS12645	COG0129	dihydroxy-acid dehydratase activity
C6Y53_RS12675	COG0583	DNA-binding transcription factor activity
C6Y53_RS12680	COG1309	transcriptional regulator
C6Y53_RS12690	COG4221	oxidoreductase activity
C6Y53_RS12715	COG1414	Transcriptional regulator
C6Y53_RS12720	COG3391	amine dehydrogenase activity
C6Y53_RS12730	COG1858	cytochrome C peroxidase
C6Y53_RS12740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C6Y53_RS12745	COG0459	protein refolding
C6Y53_RS12765	COG3454	Phosphonate metabolism
C6Y53_RS12770	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C6Y53_RS12775	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C6Y53_RS12785	COG0071	Belongs to the small heat shock protein (HSP20) family
C6Y53_RS12795	COG0384	phenazine biosynthesis protein PhzF
C6Y53_RS12805	COG0529	Catalyzes the synthesis of activated sulfate
C6Y53_RS12805	COG2046	Belongs to the sulfate adenylyltransferase family
C6Y53_RS12810	COG0492	ferredoxin-NADP+ reductase activity
C6Y53_RS12815	COG1522	sequence-specific DNA binding
C6Y53_RS12825	COG0544	peptidyl-prolyl cis-trans isomerase activity
C6Y53_RS12830	COG3916	Acyl-homoserine-lactone synthase
C6Y53_RS12840	COG1396	sequence-specific DNA binding
C6Y53_RS12845	COG0737	Belongs to the 5'-nucleotidase family
C6Y53_RS12860	COG0359	binds to the 23S rRNA
C6Y53_RS12865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C6Y53_RS12870	COG0360	Binds together with S18 to 16S ribosomal RNA
C6Y53_RS12875	COG2353	YceI-like domain
C6Y53_RS12880	COG3038	cytochrome b561
C6Y53_RS12885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C6Y53_RS12895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6Y53_RS12905	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C6Y53_RS12910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6Y53_RS12915	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C6Y53_RS12930	COG4695	Portal protein
C6Y53_RS13015	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C6Y53_RS13050	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS13070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6Y53_RS13075	COG1012	belongs to the aldehyde dehydrogenase family
C6Y53_RS13075	COG1454	alcohol dehydrogenase
C6Y53_RS13110	COG3842	ATPase activity
C6Y53_RS13120	COG1177	transmembrane transport
C6Y53_RS13125	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS13135	COG1335	isochorismatase
C6Y53_RS13145	COG1815	bacterial-type flagellum-dependent cell motility
C6Y53_RS13150	COG1558	bacterial-type flagellum-dependent cell motility
C6Y53_RS13155	COG1677	Flagellar hook-basal body complex protein FliE
C6Y53_RS13160	COG1987	bacterial-type flagellum assembly
C6Y53_RS13165	COG4786	Flagellar basal body rod
C6Y53_RS13170	COG4786	Flagellar basal body rod
C6Y53_RS13180	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C6Y53_RS13195	COG5443	negative regulation of bacterial-type flagellum assembly
C6Y53_RS13205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C6Y53_RS13225	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C6Y53_RS13230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C6Y53_RS13235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y53_RS13240	COG1177	transmembrane transport
C6Y53_RS13245	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6Y53_RS13250	COG3842	ATPase activity
C6Y53_RS13260	COG1802	Transcriptional regulator
C6Y53_RS13270	COG0006	proline dipeptidase activity
C6Y53_RS13275	COG3842	ATPase activity
C6Y53_RS13310	COG2951	lytic endotransglycosylase activity
C6Y53_RS13315	COG0557	exoribonuclease II activity
C6Y53_RS13320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6Y53_RS13325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y53_RS13335	COG2171	N-acyltransferase activity
C6Y53_RS13340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6Y53_RS13350	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C6Y53_RS13390	COG0560	Phosphoserine phosphatase
C6Y53_RS13395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C6Y53_RS13400	COG2971	BadF BadG BcrA BcrD
C6Y53_RS13405	COG2951	lytic endotransglycosylase activity
C6Y53_RS13410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C6Y53_RS13415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6Y53_RS13420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C6Y53_RS13435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS13445	COG0747	negative chemotaxis
C6Y53_RS13450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C6Y53_RS13465	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C6Y53_RS13470	COG0709	Synthesizes selenophosphate from selenide and ATP
C6Y53_RS13475	COG0028	Belongs to the TPP enzyme family
C6Y53_RS13490	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C6Y53_RS13495	COG2943	transferase activity, transferring hexosyl groups
C6Y53_RS13510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6Y53_RS13510	COG2111	Na H antiporter
C6Y53_RS13515	COG1006	Multisubunit Na H antiporter MnhC subunit
C6Y53_RS13520	COG0651	ATP synthesis coupled electron transport
C6Y53_RS13525	COG1863	multisubunit Na H antiporter MnhE subunit
C6Y53_RS13530	COG2212	antiporter activity
C6Y53_RS13535	COG1320	monovalent cation:proton antiporter activity
C6Y53_RS13560	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C6Y53_RS13595	COG0535	radical SAM domain protein
C6Y53_RS13610	COG1522	sequence-specific DNA binding
C6Y53_RS13615	COG3391	amine dehydrogenase activity
C6Y53_RS13620	COG2010	Cytochrome c
C6Y53_RS13625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C6Y53_RS13630	COG2010	Cytochrome c
C6Y53_RS13635	COG0348	domain, Protein
C6Y53_RS13635	COG3901	Regulator of nitric oxide reductase transcription
C6Y53_RS13655	COG0714	Associated with various cellular activities
C6Y53_RS13665	COG1845	cytochrome c oxidase, subunit III
C6Y53_RS13690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6Y53_RS13710	COG2113	Glycine betaine
C6Y53_RS13715	COG0517	IMP dehydrogenase activity
C6Y53_RS13715	COG4175	Glycine betaine
C6Y53_RS13720	COG4176	ABC-type proline glycine betaine transport system permease component
C6Y53_RS13735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y53_RS13755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6Y53_RS13770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6Y53_RS13780	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS13785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y53_RS13790	COG0484	heat shock protein binding
C6Y53_RS13815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6Y53_RS13825	COG0308	aminopeptidase N
C6Y53_RS13830	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C6Y53_RS13840	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C6Y53_RS13860	COG3483	tryptophan 2,3-dioxygenase activity
C6Y53_RS13870	COG0513	Belongs to the DEAD box helicase family
C6Y53_RS13890	COG0126	phosphoglycerate kinase activity
C6Y53_RS13895	COG1960	acyl-CoA dehydrogenase activity
C6Y53_RS13905	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C6Y53_RS13910	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6Y53_RS13910	COG0022	dehydrogenase e1 component
C6Y53_RS13920	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6Y53_RS13925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C6Y53_RS13950	COG0583	DNA-binding transcription factor activity
C6Y53_RS13955	COG2351	hydroxyisourate hydrolase activity
C6Y53_RS13965	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C6Y53_RS13975	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C6Y53_RS13980	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6Y53_RS13985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6Y53_RS13990	COG2233	PERMEase
C6Y53_RS13995	COG0280	phosphate acetyltransferase
C6Y53_RS13995	COG0281	malic enzyme
C6Y53_RS14000	COG2423	ornithine cyclodeaminase activity
C6Y53_RS14005	COG3616	Alanine racemase, N-terminal domain
C6Y53_RS14010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6Y53_RS14015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C6Y53_RS14020	COG1414	Transcriptional regulator
C6Y53_RS14025	COG3257	ureidoglycine aminohydrolase activity
C6Y53_RS14030	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6Y53_RS14055	COG1309	transcriptional regulator
C6Y53_RS14060	COG0747	negative chemotaxis
C6Y53_RS14065	COG0601	transmembrane transport
C6Y53_RS14070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS14075	COG0444	Belongs to the ABC transporter superfamily
C6Y53_RS14080	COG4608	Belongs to the ABC transporter superfamily
C6Y53_RS14090	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y53_RS14095	COG0352	thiamine-phosphate diphosphorylase activity
C6Y53_RS14095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C6Y53_RS14095	COG0351	phosphomethylpyrimidine kinase
C6Y53_RS14110	COG2022	thiamine diphosphate biosynthetic process
C6Y53_RS14125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C6Y53_RS14130	COG0751	glycine-tRNA ligase activity
C6Y53_RS14135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6Y53_RS14135	COG0574	Belongs to the PEP-utilizing enzyme family
C6Y53_RS14150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6Y53_RS14155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6Y53_RS14160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6Y53_RS14185	COG1573	uracil-dna glycosylase
C6Y53_RS14195	COG0625	glutathione transferase activity
C6Y53_RS14215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6Y53_RS14220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6Y53_RS14225	COG0306	phosphate transporter
C6Y53_RS14230	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS14235	COG1643	Atp-dependent helicase
C6Y53_RS14240	COG1703	isobutyryl-CoA mutase activity
C6Y53_RS14250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C6Y53_RS14260	COG2847	Copper chaperone PCu(A)C
C6Y53_RS14265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C6Y53_RS14270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6Y53_RS14275	COG0583	DNA-binding transcription factor activity
C6Y53_RS14285	COG0481	GTPase activity
C6Y53_RS14300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6Y53_RS14305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C6Y53_RS14310	COG0154	amidase activity
C6Y53_RS14320	COG0281	malic enzyme
C6Y53_RS14320	COG0280	phosphate acetyltransferase
C6Y53_RS14325	COG0295	cytidine deaminase activity
C6Y53_RS14330	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C6Y53_RS14335	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C6Y53_RS14340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C6Y53_RS14355	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y53_RS14375	COG5598	trimethylamine methyltransferase
C6Y53_RS14380	COG1902	pentaerythritol trinitrate reductase activity
C6Y53_RS14380	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6Y53_RS14395	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C6Y53_RS14400	COG1999	signal sequence binding
C6Y53_RS14410	COG2205	protein histidine kinase activity
C6Y53_RS14415	COG0802	atpase or kinase
C6Y53_RS14420	COG3178	'Phosphotransferase
C6Y53_RS14425	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C6Y53_RS14430	COG2887	Belongs to the helicase family. UvrD subfamily
C6Y53_RS14435	COG1074	ATP-dependent DNA helicase activity
C6Y53_RS14450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C6Y53_RS14455	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C6Y53_RS14465	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C6Y53_RS14470	COG1530	ribonuclease E activity
C6Y53_RS14475	COG0424	maF-like protein
C6Y53_RS14495	COG5328	Belongs to the UPF0262 family
C6Y53_RS14500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C6Y53_RS14510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C6Y53_RS14605	COG1228	amidohydrolase
C6Y53_RS14610	COG0583	DNA-binding transcription factor activity
C6Y53_RS14615	COG0747	negative chemotaxis
C6Y53_RS14620	COG0601	transmembrane transport
C6Y53_RS14625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS14630	COG0444	Belongs to the ABC transporter superfamily
C6Y53_RS14635	COG4608	Belongs to the ABC transporter superfamily
C6Y53_RS14675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6Y53_RS14680	COG1846	Transcriptional regulator
C6Y53_RS14685	COG0745	RESPONSE REGULATOR receiver
C6Y53_RS14690	COG0123	including yeast histone deacetylase and acetoin utilization protein
C6Y53_RS14695	COG1722	exodeoxyribonuclease VII activity
C6Y53_RS14700	COG0142	geranyltranstransferase activity
C6Y53_RS14705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C6Y53_RS14730	COG1960	acyl-CoA dehydrogenase activity
C6Y53_RS14745	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C6Y53_RS14750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C6Y53_RS14755	COG0776	regulation of translation
C6Y53_RS14775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6Y53_RS14780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6Y53_RS14785	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C6Y53_RS14810	COG1706	bacterial-type flagellum-dependent cell motility
C6Y53_RS14815	COG1338	Plays a role in the flagellum-specific transport system
C6Y53_RS14830	COG1766	The M ring may be actively involved in energy transduction
C6Y53_RS14855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C6Y53_RS14865	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C6Y53_RS14880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C6Y53_RS14885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C6Y53_RS14890	COG2897	thiosulfate sulfurtransferase activity
C6Y53_RS14900	COG0004	ammonium transporteR
C6Y53_RS14910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6Y53_RS14930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y53_RS14950	COG2154	pterin-4-alpha-carbinolamine dehydratase
C6Y53_RS14955	COG0678	peroxiredoxin activity
C6Y53_RS14965	COG0742	ribosomal rna small subunit methyltransferase
C6Y53_RS14970	COG0024	Methionine aminopeptidase
C6Y53_RS14975	COG1489	DNA binding
C6Y53_RS14980	COG1058	Belongs to the CinA family
C6Y53_RS14980	COG1546	Belongs to the CinA family
C6Y53_RS15000	COG1902	pentaerythritol trinitrate reductase activity
C6Y53_RS15000	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6Y53_RS15005	COG1051	belongs to the nudix hydrolase family
C6Y53_RS15020	COG2354	Protein conserved in bacteria
C6Y53_RS15025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C6Y53_RS15045	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C6Y53_RS15050	COG0271	Belongs to the BolA IbaG family
C6Y53_RS15055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6Y53_RS15065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6Y53_RS15070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C6Y53_RS15075	COG2169	Transcriptional regulator
C6Y53_RS15075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6Y53_RS15080	COG2885	chlorophyll binding
C6Y53_RS15095	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C6Y53_RS15105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y53_RS15105	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C6Y53_RS15120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6Y53_RS15130	COG0437	4 iron, 4 sulfur cluster binding
C6Y53_RS15135	COG0243	molybdopterin cofactor binding
C6Y53_RS15140	COG0372	Belongs to the citrate synthase family
C6Y53_RS15145	COG0857	belongs to the CobB CobQ family
C6Y53_RS15145	COG0280	phosphate acetyltransferase
C6Y53_RS15150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6Y53_RS15175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6Y53_RS15185	COG1116	anion transmembrane transporter activity
C6Y53_RS15190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y53_RS15200	COG3842	ATPase activity
C6Y53_RS15210	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C6Y53_RS15235	COG3938	Belongs to the proline racemase family
C6Y53_RS15240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y53_RS15245	COG4608	Belongs to the ABC transporter superfamily
C6Y53_RS15250	COG0444	Belongs to the ABC transporter superfamily
C6Y53_RS15255	COG2031	fatty acid transporter
C6Y53_RS15260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS15265	COG0601	transmembrane transport
C6Y53_RS15270	COG0006	proline dipeptidase activity
C6Y53_RS15275	COG0747	negative chemotaxis
C6Y53_RS15310	COG0174	glutamine synthetase
C6Y53_RS15315	COG1012	belongs to the aldehyde dehydrogenase family
C6Y53_RS15330	COG2267	carboxylic ester hydrolase activity
C6Y53_RS15360	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C6Y53_RS15375	COG0514	ATP-dependent DNA helicase (RecQ)
C6Y53_RS15380	COG3022	response to hydroperoxide
C6Y53_RS15415	COG0714	Associated with various cellular activities
C6Y53_RS15425	COG0640	Transcriptional regulator
C6Y53_RS15430	COG0798	PFAM Bile acid sodium symporter
C6Y53_RS15435	COG3622	Belongs to the hyi family
C6Y53_RS15440	COG0159	tryptophan synthase activity
C6Y53_RS15445	COG0012	GTP binding
C6Y53_RS15455	COG0800	Aldolase
C6Y53_RS15460	COG3734	2-keto-3-deoxy-galactonokinase
C6Y53_RS15470	COG1070	Carbohydrate kinase
C6Y53_RS15475	COG2115	Belongs to the xylose isomerase family
C6Y53_RS15490	COG1940	carbohydrate kinase activity
C6Y53_RS15490	COG1846	Transcriptional regulator
C6Y53_RS15495	COG4213	ABC transporter substrate-binding protein
C6Y53_RS15500	COG4214	carbohydrate transport
C6Y53_RS15510	COG0837	glucose binding
C6Y53_RS15525	COG2351	hydroxyisourate hydrolase activity
C6Y53_RS15545	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C6Y53_RS15550	COG0509	glycine decarboxylation via glycine cleavage system
C6Y53_RS15555	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6Y53_RS15555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6Y53_RS15570	COG0101	tRNA pseudouridine synthase activity
C6Y53_RS15575	COG3106	COG3106 Predicted ATPase
C6Y53_RS15580	COG3768	UPF0283 membrane protein
C6Y53_RS15595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C6Y53_RS15600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6Y53_RS15605	COG1183	phosphatidylcholine synthase activity
C6Y53_RS15610	COG4974	Belongs to the 'phage' integrase family
C6Y53_RS15620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6Y53_RS15645	COG2264	protein methyltransferase activity
C6Y53_RS15655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6Y53_RS15660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6Y53_RS15680	COG1566	PFAM secretion protein HlyD family protein
C6Y53_RS15695	COG0604	alcohol dehydrogenase
C6Y53_RS15715	COG0405	Gamma-glutamyltransferase
C6Y53_RS15720	COG0277	FAD linked oxidase domain protein
C6Y53_RS15725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C6Y53_RS15735	COG1522	sequence-specific DNA binding
C6Y53_RS15740	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C6Y53_RS15745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6Y53_RS15755	COG1802	Transcriptional regulator
C6Y53_RS15765	COG0505	Belongs to the CarA family
C6Y53_RS15780	COG4215	(ABC) transporter
C6Y53_RS15800	COG0668	transmembrane transport
C6Y53_RS15820	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C6Y53_RS15825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C6Y53_RS15830	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C6Y53_RS15845	COG1138	Cytochrome C-type biogenesis protein
C6Y53_RS15850	COG3088	subunit of a heme lyase
C6Y53_RS15855	COG1024	Enoyl-CoA hydratase
C6Y53_RS15865	COG1079	Belongs to the binding-protein-dependent transport system permease family
C6Y53_RS15870	COG4603	Belongs to the binding-protein-dependent transport system permease family
C6Y53_RS15875	COG3845	ABC transporter
C6Y53_RS15885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6Y53_RS15890	COG2080	2 iron, 2 sulfur cluster binding
C6Y53_RS15900	COG2900	Belongs to the SlyX family
C6Y53_RS15905	COG1024	Enoyl-CoA hydratase
C6Y53_RS15910	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C6Y53_RS15925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6Y53_RS15935	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6Y53_RS15935	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C6Y53_RS15950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y53_RS15955	COG0028	Belongs to the TPP enzyme family
C6Y53_RS15960	COG2855	membrane
C6Y53_RS15975	COG0512	Glutamine amidotransferase of anthranilate synthase
C6Y53_RS15975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C6Y53_RS15985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y53_RS16000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6Y53_RS16010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C6Y53_RS16015	COG3485	protocatechuate 3,4-dioxygenase
C6Y53_RS16020	COG3485	protocatechuate 3,4-dioxygenase
C6Y53_RS16025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6Y53_RS16040	COG0714	Associated with various cellular activities
C6Y53_RS16070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6Y53_RS16090	COG1024	Enoyl-CoA hydratase
C6Y53_RS16100	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C6Y53_RS16115	COG0583	DNA-binding transcription factor activity
C6Y53_RS16125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C6Y53_RS16150	COG0156	8-amino-7-oxononanoate synthase activity
C6Y53_RS16160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C6Y53_RS16170	COG0501	Belongs to the peptidase M48B family
C6Y53_RS16175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C6Y53_RS16180	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C6Y53_RS16200	COG0440	acetolactate synthase activity
C6Y53_RS16205	COG0028	Belongs to the TPP enzyme family
C6Y53_RS16220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6Y53_RS16225	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C6Y53_RS16250	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C6Y53_RS16270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6Y53_RS16295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C6Y53_RS16320	COG0316	Belongs to the HesB IscA family
C6Y53_RS16325	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C6Y53_RS16330	COG0018	arginyl-trna synthetase
C6Y53_RS16340	COG1472	Belongs to the glycosyl hydrolase 3 family
C6Y53_RS16345	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C6Y53_RS16350	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C6Y53_RS16385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C6Y53_RS16390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C6Y53_RS16415	COG0321	lipoyl(octanoyl) transferase activity
C6Y53_RS16420	COG0537	adenosine 5'-monophosphoramidase activity
C6Y53_RS16460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6Y53_RS16465	COG0730	response to heat
C6Y53_RS16475	COG5002	protein histidine kinase activity
C6Y53_RS16475	COG2176	DNA-directed DNA polymerase activity
C6Y53_RS16490	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6Y53_RS16500	COG0563	adenylate kinase activity
C6Y53_RS16505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6Y53_RS16530	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y53_RS16535	COG1920	GTP binding
C6Y53_RS16545	COG4536	flavin adenine dinucleotide binding
C6Y53_RS16550	COG4974	Belongs to the 'phage' integrase family
C6Y53_RS16560	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C6Y53_RS16565	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C6Y53_RS16570	COG0517	IMP dehydrogenase activity
C6Y53_RS16570	COG1994	Peptidase M50
C6Y53_RS16575	COG0629	single-stranded DNA binding
C6Y53_RS16580	COG0739	heme binding
C6Y53_RS16580	COG1196	nuclear chromosome segregation
C6Y53_RS16580	COG0741	lytic transglycosylase activity
C6Y53_RS16590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS16595	COG0601	transmembrane transport
C6Y53_RS16605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C6Y53_RS16610	COG0528	UMP kinase activity
C6Y53_RS16615	COG0233	cytoplasmic translational termination
C6Y53_RS16620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6Y53_RS16630	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C6Y53_RS16635	COG0750	zinc metalloprotease
C6Y53_RS16640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6Y53_RS16650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C6Y53_RS16655	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6Y53_RS16665	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6Y53_RS16670	COG0482	sulfurtransferase activity
C6Y53_RS16680	COG0745	RESPONSE REGULATOR receiver
C6Y53_RS16685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6Y53_RS16690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C6Y53_RS16700	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C6Y53_RS16705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6Y53_RS16710	COG2264	protein methyltransferase activity
C6Y53_RS16715	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C6Y53_RS16720	COG1024	Enoyl-CoA hydratase
C6Y53_RS16730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C6Y53_RS16745	COG1309	transcriptional regulator
C6Y53_RS16750	COG2326	polyphosphate kinase activity
C6Y53_RS16775	COG0697	spore germination
C6Y53_RS16785	COG0248	Ppx GppA phosphatase
C6Y53_RS16795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C6Y53_RS16810	COG2076	Multidrug Resistance protein
C6Y53_RS16835	COG0538	isocitrate dehydrogenase activity
C6Y53_RS16840	COG0657	acetylesterase activity
C6Y53_RS16850	COG2945	thiolester hydrolase activity
C6Y53_RS16855	COG1959	2 iron, 2 sulfur cluster binding
C6Y53_RS16860	COG1104	cysteine desulfurase activity
C6Y53_RS16865	COG0719	Fe-S assembly protein
C6Y53_RS16875	COG0396	ATPase activity
C6Y53_RS16880	COG0719	Fe-S assembly protein
C6Y53_RS16895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C6Y53_RS16905	COG0803	Belongs to the bacterial solute-binding protein 9 family
C6Y53_RS16910	COG1121	(ABC) transporter
C6Y53_RS16915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6Y53_RS16920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6Y53_RS16935	COG3008	intermembrane lipid transfer
C6Y53_RS16935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C6Y53_RS16940	COG2995	paraquat-inducible protein a
C6Y53_RS16995	COG3842	ATPase activity
C6Y53_RS17000	COG1840	ABC-type Fe3 transport system, periplasmic component
C6Y53_RS17020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C6Y53_RS17035	COG0516	GMP reductase activity
C6Y53_RS17035	COG0517	IMP dehydrogenase activity
C6Y53_RS17055	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C6Y53_RS17060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C6Y53_RS17075	COG0372	Belongs to the citrate synthase family
C6Y53_RS17080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6Y53_RS17085	COG0658	competence protein
C6Y53_RS17085	COG2333	competence protein COMEC
C6Y53_RS17090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C6Y53_RS17095	COG0303	'Molybdopterin
C6Y53_RS17100	COG0315	cyclic pyranopterin monophosphate synthase activity
C6Y53_RS17110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C6Y53_RS17125	COG0436	Aminotransferase
C6Y53_RS17130	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C6Y53_RS17135	COG1280	lysine exporter protein (LysE YggA)
C6Y53_RS17140	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C6Y53_RS17145	COG0259	pyridoxamine-phosphate oxidase activity
C6Y53_RS17150	COG1278	Cold shock
C6Y53_RS17165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6Y53_RS17210	COG1024	Enoyl-CoA hydratase
C6Y53_RS17215	COG2030	dehydratase
C6Y53_RS17215	COG1012	belongs to the aldehyde dehydrogenase family
C6Y53_RS17225	COG1522	sequence-specific DNA binding
C6Y53_RS17235	COG0506	proline dehydrogenase activity
C6Y53_RS17235	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C6Y53_RS17235	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C6Y53_RS17240	COG1522	sequence-specific DNA binding
C6Y53_RS17260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6Y53_RS17265	COG1780	Probably involved in ribonucleotide reductase function
C6Y53_RS17360	COG1228	amidohydrolase
C6Y53_RS17450	COG0741	lytic transglycosylase activity
C6Y53_RS17450	COG1196	nuclear chromosome segregation
C6Y53_RS17450	COG0739	heme binding
C6Y53_RS17455	COG3451	type IV secretory pathway VirB4
C6Y53_RS17470	COG0741	lytic transglycosylase activity
C6Y53_RS17520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C6Y53_RS17530	COG1404	Belongs to the peptidase S8 family
C6Y53_RS17575	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y53_RS17575	COG1024	Enoyl-CoA hydratase
C6Y53_RS17580	COG0183	Belongs to the thiolase family
C6Y53_RS17585	COG0625	glutathione transferase activity
C6Y53_RS17590	COG1960	acyl-CoA dehydrogenase activity
C6Y53_RS17615	COG0534	Mate efflux family protein
C6Y53_RS17630	COG0739	heme binding
C6Y53_RS17635	COG2833	Protein of unknown function (DUF455)
C6Y53_RS17640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C6Y53_RS17650	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C6Y53_RS17670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6Y53_RS17695	COG0737	Belongs to the 5'-nucleotidase family
C6Y53_RS17700	COG0457	Tetratricopeptide repeat
C6Y53_RS17705	COG0670	Belongs to the BI1 family
C6Y53_RS17715	COG0583	DNA-binding transcription factor activity
C6Y53_RS17725	COG1396	sequence-specific DNA binding
C6Y53_RS17730	COG0483	inositol monophosphate 1-phosphatase activity
C6Y53_RS17750	COG2022	thiamine diphosphate biosynthetic process
C6Y53_RS17755	COG3220	belongs to the UPF0276 family
C6Y53_RS17765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C6Y53_RS17795	COG3243	poly(R)-hydroxyalkanoic acid synthase
C6Y53_RS17825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C6Y53_RS17830	COG1132	(ABC) transporter
C6Y53_RS17835	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y53_RS17860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6Y53_RS17865	COG0601	transmembrane transport
C6Y53_RS17870	COG4533	DNA binding
C6Y53_RS17875	COG2379	hydroxypyruvate reductase
C6Y53_RS17880	COG1490	D-aminoacyl-tRNA deacylase activity
C6Y53_RS17895	COG0105	UTP biosynthetic process
C6Y53_RS17900	COG0488	(ABC) transporter
C6Y53_RS17905	COG2095	MarC family integral membrane protein
C6Y53_RS17930	COG3853	Toxic anion resistance protein (TelA)
C6Y53_RS17940	COG1187	pseudouridine synthase activity
C6Y53_RS17945	COG0590	tRNA wobble adenosine to inosine editing
C6Y53_RS17965	COG0154	amidase activity
C6Y53_RS17970	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6Y53_RS17975	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C6Y53_RS17980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C6Y53_RS17985	COG0789	Transcriptional regulator
C6Y53_RS18000	COG2072	flavoprotein involved in K transport
C6Y53_RS18030	COG1177	transmembrane transport
C6Y53_RS18035	COG3842	ATPase activity
C6Y53_RS18040	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C6Y53_RS18045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6Y53_RS18050	COG4558	Periplasmic binding protein
C6Y53_RS18095	COG4607	ABC-type enterochelin transport system periplasmic component
C6Y53_RS18100	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6Y53_RS18105	COG4605	iron ion homeostasis
C6Y53_RS18110	COG4604	ABC transporter, ATP-binding protein
C6Y53_RS18125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6Y53_RS18130	COG2358	TRAP transporter, solute receptor (TAXI family
C6Y53_RS18155	COG0577	efflux transmembrane transporter activity
C6Y53_RS18160	COG1136	(ABC) transporter
C6Y53_RS18190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C6Y53_RS18195	COG0519	Catalyzes the synthesis of GMP from XMP
C6Y53_RS18195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6Y53_RS18220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C6Y53_RS18225	COG2010	Cytochrome c
C6Y53_RS18235	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C6Y53_RS18240	COG2867	negative regulation of translational initiation
C6Y53_RS18250	COG1546	Belongs to the CinA family
C6Y53_RS18250	COG1058	Belongs to the CinA family
C6Y53_RS18260	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C6Y53_RS18260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C6Y53_RS18265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6Y53_RS18270	COG3852	Histidine kinase
C6Y53_RS18275	COG2204	response regulator
C6Y53_RS18280	COG5000	phosphorelay sensor kinase activity
C6Y53_RS18285	COG2204	response regulator
C6Y53_RS18295	COG0569	domain protein
C6Y53_RS18305	COG1923	regulation of RNA biosynthetic process
C6Y53_RS18310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C6Y53_RS18320	COG2084	Dehydrogenase
C6Y53_RS18330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6Y53_RS18335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y53_RS18340	COG0174	glutamine synthetase
C6Y53_RS18345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6Y53_RS18345	COG0519	Catalyzes the synthesis of GMP from XMP
C6Y53_RS18350	COG0174	glutamine synthetase
C6Y53_RS18360	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y53_RS18365	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS18370	COG1946	Acyl-CoA thioesterase
C6Y53_RS18375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6Y53_RS18385	COG1024	Enoyl-CoA hydratase
C6Y53_RS18390	COG1131	(ABC) transporter
C6Y53_RS18410	COG0683	leucine binding
C6Y53_RS18430	COG0183	Belongs to the thiolase family
C6Y53_RS18435	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y53_RS18450	COG2130	NADP-dependent
C6Y53_RS18460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C6Y53_RS18465	COG2197	response regulator
C6Y53_RS18470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C6Y53_RS18475	COG0052	Belongs to the universal ribosomal protein uS2 family
C6Y53_RS18500	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C6Y53_RS18505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C6Y53_RS18510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C6Y53_RS18520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C6Y53_RS18525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C6Y53_RS18525	COG3743	rRNA binding
C6Y53_RS18540	COG1970	mechanosensitive ion channel activity
C6Y53_RS18590	COG1959	2 iron, 2 sulfur cluster binding
C6Y53_RS18600	COG3189	MarR family transcriptional regulator
C6Y53_RS18605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C6Y53_RS18625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C6Y53_RS18640	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C6Y53_RS18650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C6Y53_RS18655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6Y53_RS18665	COG2890	protein-(glutamine-N5) methyltransferase activity
C6Y53_RS18670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C6Y53_RS18685	COG0010	Belongs to the arginase family
C6Y53_RS18690	COG1473	amidohydrolase
C6Y53_RS18695	COG3956	TIGRFAM MazG family protein
C6Y53_RS18710	COG0148	phosphopyruvate hydratase activity
C6Y53_RS18715	COG0697	spore germination
C6Y53_RS18730	COG0513	Belongs to the DEAD box helicase family
C6Y53_RS18750	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C6Y53_RS18760	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C6Y53_RS18765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C6Y53_RS18775	COG0488	(ABC) transporter
C6Y53_RS18795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C6Y53_RS18800	COG0416	fatty acid biosynthetic process
C6Y53_RS18805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C6Y53_RS18810	COG0776	regulation of translation
C6Y53_RS18825	COG0717	Belongs to the dCTP deaminase family
C6Y53_RS18830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6Y53_RS18830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6Y53_RS18835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C6Y53_RS18840	COG0432	Pfam Uncharacterised protein family UPF0047
C6Y53_RS18860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released