locus-tag	class	description
CN03_RS00045	COG0730	response to heat
CN03_RS00060	COG3108	Peptidase M15
CN03_RS00065	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CN03_RS00070	COG0494	nUDIX hydrolase
CN03_RS00095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CN03_RS00100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CN03_RS00105	COG0006	proline dipeptidase activity
CN03_RS00130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CN03_RS00155	COG1217	gtp-binding protein TYPA
CN03_RS00165	COG0281	malic enzyme
CN03_RS00175	COG0745	RESPONSE REGULATOR receiver
CN03_RS00180	COG0628	permease
CN03_RS00195	COG1346	cytolysis
CN03_RS00205	COG0494	nUDIX hydrolase
CN03_RS00210	COG1011	Hydrolase
CN03_RS00215	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CN03_RS00220	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CN03_RS00225	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CN03_RS00230	COG2183	response to ionizing radiation
CN03_RS00235	COG2918	glutathione biosynthetic process
CN03_RS00245	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CN03_RS00280	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CN03_RS00290	COG2832	Protein of unknown function (DUF454)
CN03_RS00300	COG0488	(ABC) transporter
CN03_RS00315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CN03_RS00320	COG2363	Small membrane protein
CN03_RS00325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CN03_RS00335	COG0668	transmembrane transport
CN03_RS00355	COG2959	enzyme of heme biosynthesis
CN03_RS00365	COG0181	hydroxymethylbilane synthase activity
CN03_RS00380	COG0165	Argininosuccinate lyase
CN03_RS00400	COG2307	Protein conserved in bacteria
CN03_RS00400	COG2308	Evidence 4 Homologs of previously reported genes of
CN03_RS00415	COG2308	Evidence 4 Homologs of previously reported genes of
CN03_RS00435	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CN03_RS00455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CN03_RS00460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CN03_RS00470	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CN03_RS00480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CN03_RS00490	COG0356	it plays a direct role in the translocation of protons across the membrane
CN03_RS00505	COG1475	DNA binding
CN03_RS00510	COG1192	Involved in chromosome partitioning
CN03_RS00515	COG0357	Ribosomal RNA small subunit methyltransferase G
CN03_RS00580	COG0445	tRNA wobble uridine modification
CN03_RS00605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CN03_RS00610	COG0706	membrane insertase activity
CN03_RS00620	COG0594	ribonuclease P activity
CN03_RS00625	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CN03_RS00630	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CN03_RS00635	COG0592	DNA-directed DNA polymerase activity
CN03_RS00640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CN03_RS00660	COG0668	transmembrane transport
CN03_RS00675	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CN03_RS00680	COG0751	glycine-tRNA ligase activity
CN03_RS00690	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CN03_RS00730	COG3150	esterase
CN03_RS00735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CN03_RS00740	COG3151	Protein conserved in bacteria
CN03_RS00745	COG0494	nUDIX hydrolase
CN03_RS00750	COG1538	Outer membrane efflux protein
CN03_RS00755	COG1519	Transferase
CN03_RS00765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CN03_RS00770	COG1560	Kdo2-lipid A biosynthetic process
CN03_RS00775	COG0515	serine threonine protein kinase
CN03_RS00780	COG2116	formate transmembrane transporter activity
CN03_RS00785	COG1960	acyl-CoA dehydrogenase activity
CN03_RS00790	COG1028	Short-chain dehydrogenase reductase Sdr
CN03_RS00805	COG1028	Short-chain dehydrogenase reductase Sdr
CN03_RS00815	COG1404	Belongs to the peptidase S8 family
CN03_RS00840	COG2203	Gaf domain
CN03_RS00840	COG5001	Diguanylate cyclase
CN03_RS00840	COG4251	negative regulation of phosphorylation
CN03_RS00840	COG3706	GGDEF domain
CN03_RS00875	COG1404	Belongs to the peptidase S8 family
CN03_RS00895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CN03_RS00900	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CN03_RS00930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CN03_RS00935	COG1349	DNA-binding transcription factor activity
CN03_RS00960	COG3245	cytochrome
CN03_RS00965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CN03_RS00995	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CN03_RS01030	COG4774	siderophore transport
CN03_RS01040	COG0501	Belongs to the peptidase M48B family
CN03_RS01045	COG3437	response regulator, receiver
CN03_RS01045	COG2205	protein histidine kinase activity
CN03_RS01045	COG3850	Histidine kinase
CN03_RS01045	COG4999	Histidine kinase
CN03_RS01050	COG4372	Transposase
CN03_RS01065	COG2205	protein histidine kinase activity
CN03_RS01065	COG0784	Response regulator, receiver
CN03_RS01100	COG0339	signal peptide processing
CN03_RS01105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CN03_RS01125	COG2010	Cytochrome c
CN03_RS01140	COG3148	PFAM DTW domain containing protein
CN03_RS01150	COG0217	transcriptional regulatory protein
CN03_RS01165	COG0408	coproporphyrinogen oxidase activity
CN03_RS01170	COG0009	L-threonylcarbamoyladenylate synthase
CN03_RS01175	COG0758	DNA mediated transformation
CN03_RS01185	COG0242	peptide deformylase activity
CN03_RS01190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CN03_RS01200	COG0569	domain protein
CN03_RS01205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CN03_RS01210	COG0659	secondary active sulfate transmembrane transporter activity
CN03_RS01215	COG0589	response to stress
CN03_RS01220	COG1595	DNA-templated transcription, initiation
CN03_RS01245	COG0745	RESPONSE REGULATOR receiver
CN03_RS01255	COG0742	ribosomal rna small subunit methyltransferase
CN03_RS01265	COG0552	protein localization to endoplasmic reticulum
CN03_RS01270	COG2884	Cell division ATP-binding protein ftsE
CN03_RS01275	COG2177	Part of the ABC transporter FtsEX involved in
CN03_RS01285	COG1607	acyl-coa hydrolase
CN03_RS01305	COG0573	inorganic phosphate transmembrane transporter activity
CN03_RS01315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CN03_RS01330	COG5002	protein histidine kinase activity
CN03_RS01345	COG0393	Putative heavy-metal-binding
CN03_RS01375	COG0582	viral genome integration into host DNA
CN03_RS01390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CN03_RS01415	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CN03_RS01445	COG1301	dicarboxylic acid transport
CN03_RS01460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CN03_RS01465	COG0583	DNA-binding transcription factor activity
CN03_RS01485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CN03_RS01490	COG1758	RNA polymerase activity
CN03_RS01495	COG0194	GDP metabolic process
CN03_RS01500	COG3384	dioxygenase
CN03_RS01515	COG3012	SEC-C Motif Domain Protein
CN03_RS01545	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CN03_RS01555	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CN03_RS01565	COG1561	YicC-like family, N-terminal region
CN03_RS01570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CN03_RS01580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CN03_RS01590	COG1309	transcriptional regulator
CN03_RS01595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CN03_RS01600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CN03_RS01605	COG0756	dUTP diphosphatase activity
CN03_RS01610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CN03_RS01615	COG2003	Belongs to the UPF0758 family
CN03_RS01620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CN03_RS01625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CN03_RS01640	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CN03_RS01645	COG0405	Gamma-glutamyltransferase
CN03_RS01650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CN03_RS01660	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CN03_RS01700	COG3273	potassium ion transport
CN03_RS01700	COG0471	metal ion transport
CN03_RS01715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CN03_RS01720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CN03_RS01725	COG0537	adenosine 5'-monophosphoramidase activity
CN03_RS01730	COG0140	phosphoribosyl-ATP diphosphatase activity
CN03_RS01735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CN03_RS01740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CN03_RS01750	COG2226	methyltransferase
CN03_RS01775	COG4771	TonB-dependent receptor
CN03_RS01780	COG2885	chlorophyll binding
CN03_RS01795	COG4181	ATPase activity
CN03_RS01800	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CN03_RS01805	COG0501	Belongs to the peptidase M48B family
CN03_RS01810	COG1704	LemA family
CN03_RS01825	COG0513	Belongs to the DEAD box helicase family
CN03_RS01875	COG0540	Belongs to the ATCase OTCase family
CN03_RS01880	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CN03_RS01890	COG1678	Uncharacterized ACR, COG1678
CN03_RS01930	COG0643	Histidine kinase
CN03_RS01930	COG2198	Histidine kinase
CN03_RS01930	COG0784	Response regulator, receiver
CN03_RS01935	COG2201	protein-glutamate methylesterase activity
CN03_RS01950	COG0438	transferase activity, transferring glycosyl groups
CN03_RS01955	COG2194	sulfuric ester hydrolase activity
CN03_RS01980	COG3562	capsule polysaccharide
CN03_RS01985	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CN03_RS01990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CN03_RS01995	COG0640	Transcriptional regulator
CN03_RS02000	COG0714	Associated with various cellular activities
CN03_RS02010	COG1305	Transglutaminase-like
CN03_RS02020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CN03_RS02030	COG0121	glutamine amidotransferase
CN03_RS02050	COG1177	transmembrane transport
CN03_RS02055	COG1176	ABC-type spermidine putrescine transport system, permease component I
CN03_RS02060	COG3842	ATPase activity
CN03_RS02065	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CN03_RS02075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CN03_RS02095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CN03_RS02100	COG1981	membrane
CN03_RS02110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CN03_RS02125	COG0316	Belongs to the HesB IscA family
CN03_RS02140	COG0739	heme binding
CN03_RS02185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CN03_RS02195	COG0456	acetyltransferase
CN03_RS02205	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CN03_RS02220	COG0018	arginyl-trna synthetase
CN03_RS02225	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CN03_RS02230	COG0514	ATP-dependent DNA helicase (RecQ)
CN03_RS02250	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CN03_RS02275	COG0131	Imidazoleglycerol-phosphate dehydratase
CN03_RS02280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CN03_RS02285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CN03_RS02290	COG0107	imidazoleglycerol-phosphate synthase activity
CN03_RS02305	COG0129	dihydroxy-acid dehydratase activity
CN03_RS02450	COG0631	protein serine/threonine phosphatase activity
CN03_RS02480	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CN03_RS02490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CN03_RS02495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CN03_RS02500	COG0723	plastoquinol--plastocyanin reductase activity
CN03_RS02505	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CN03_RS02510	COG2857	Cytochrome c1
CN03_RS02515	COG0625	glutathione transferase activity
CN03_RS02520	COG2969	positive regulation of protein catabolic process
CN03_RS02525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CN03_RS02595	COG4115	mRNA cleavage
CN03_RS02600	COG2161	toxin-antitoxin pair type II binding
CN03_RS02615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CN03_RS02620	COG0154	amidase activity
CN03_RS02625	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CN03_RS02630	COG1077	Cell shape determining protein MreB Mrl
CN03_RS02635	COG1792	Involved in formation and maintenance of cell shape
CN03_RS02640	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CN03_RS02645	COG0424	maF-like protein
CN03_RS02650	COG1530	ribonuclease E activity
CN03_RS02660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CN03_RS02665	COG3028	Belongs to the UPF0307 family
CN03_RS02670	COG2239	Acts as a magnesium transporter
CN03_RS02675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CN03_RS02680	COG1660	Displays ATPase and GTPase activities
CN03_RS02700	COG1137	ATPase activity
CN03_RS02705	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CN03_RS02725	COG1127	ABC transporter
CN03_RS02730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CN03_RS02735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CN03_RS02745	COG5007	Belongs to the BolA IbaG family
CN03_RS02750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CN03_RS02755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CN03_RS02760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CN03_RS02765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CN03_RS02770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CN03_RS02775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CN03_RS02785	COG2354	Protein conserved in bacteria
CN03_RS02790	COG0697	spore germination
CN03_RS02800	COG0504	CTP synthase activity
CN03_RS02850	COG3706	GGDEF domain
CN03_RS02855	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CN03_RS02860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CN03_RS02865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CN03_RS02870	COG0585	pseudouridine synthase activity
CN03_RS02880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CN03_RS02900	COG1396	sequence-specific DNA binding
CN03_RS02910	COG1061	Type III restriction enzyme res subunit
CN03_RS02920	COG2963	transposase activity
CN03_RS02925	COG2801	Transposase and inactivated derivatives
CN03_RS02960	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CN03_RS02975	COG0535	radical SAM domain protein
CN03_RS02985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CN03_RS03000	COG1401	restriction endodeoxyribonuclease activity
CN03_RS03035	COG3645	SOS response
CN03_RS03065	COG0629	single-stranded DNA binding
CN03_RS03070	COG2814	Major facilitator Superfamily
CN03_RS03075	COG2197	response regulator
CN03_RS03105	COG0560	Phosphoserine phosphatase
CN03_RS03105	COG3830	Belongs to the UPF0237 family
CN03_RS03110	COG2199	diguanylate cyclase activity
CN03_RS03120	COG1509	lysine 2,3-aminomutase activity
CN03_RS03125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CN03_RS03150	COG0583	DNA-binding transcription factor activity
CN03_RS03155	COG0688	phosphatidylethanolamine metabolic process
CN03_RS03175	COG1360	Flagellar Motor Protein
CN03_RS03180	COG1162	GTPase activity
CN03_RS03185	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CN03_RS03195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CN03_RS03195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CN03_RS03200	COG0802	atpase or kinase
CN03_RS03205	COG0860	N-Acetylmuramoyl-L-alanine amidase
CN03_RS03210	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CN03_RS03215	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CN03_RS03220	COG1923	regulation of RNA biosynthetic process
CN03_RS03225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CN03_RS03230	COG0330	HflC and HflK could
CN03_RS03235	COG0330	HflC and HflK could
CN03_RS03245	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CN03_RS03250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CN03_RS03260	COG3153	acetyltransferase
CN03_RS03260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CN03_RS03265	COG0583	DNA-binding transcription factor activity
CN03_RS03315	COG2801	Transposase and inactivated derivatives
CN03_RS03320	COG2963	transposase activity
CN03_RS03345	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CN03_RS03350	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CN03_RS03355	COG0235	Class ii aldolase
CN03_RS03360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CN03_RS03365	COG0166	Belongs to the GPI family
CN03_RS03370	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CN03_RS03375	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CN03_RS03380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CN03_RS03385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CN03_RS03390	COG0617	tRNA 3'-terminal CCA addition
CN03_RS03400	COG4191	Histidine kinase
CN03_RS03410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CN03_RS03420	COG0436	Aminotransferase
CN03_RS03425	COG1489	DNA binding
CN03_RS03435	COG3153	acetyltransferase
CN03_RS03435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CN03_RS03445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CN03_RS03465	COG0417	DNA replication proofreading
CN03_RS03470	COG0598	Magnesium transport protein CorA
CN03_RS03490	COG2861	carbohydrate metabolic process
CN03_RS03495	COG0793	Belongs to the peptidase S41A family
CN03_RS03500	COG4942	peptidase
CN03_RS03505	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CN03_RS03510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CN03_RS03515	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CN03_RS03555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CN03_RS03585	COG3267	Type II secretory pathway component ExeA
CN03_RS03585	COG3409	Peptidoglycan-binding domain 1 protein
CN03_RS03595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CN03_RS03600	COG1459	type II secretion system
CN03_RS03610	COG2165	general secretion pathway protein
CN03_RS03650	COG2204	response regulator
CN03_RS03690	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CN03_RS03705	COG2119	membrane
CN03_RS03740	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CN03_RS03745	COG2894	cell division
CN03_RS03750	COG0850	regulation of cytokinetic process
CN03_RS03760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CN03_RS03765	COG0671	phosphoesterase, PA-phosphatase related
CN03_RS03770	COG0438	transferase activity, transferring glycosyl groups
CN03_RS03815	COG0579	oxidoreductase
CN03_RS03860	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CN03_RS03865	COG2951	lytic endotransglycosylase activity
CN03_RS03870	COG0772	Belongs to the SEDS family
CN03_RS03875	COG0768	penicillin binding
CN03_RS03880	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CN03_RS03895	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CN03_RS03915	COG0586	Pfam SNARE associated Golgi protein
CN03_RS03925	COG3098	single-species biofilm formation
CN03_RS03950	COG1686	Belongs to the peptidase S11 family
CN03_RS03955	COG2921	Belongs to the UPF0250 family
CN03_RS03960	COG0321	lipoyl(octanoyl) transferase activity
CN03_RS03965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CN03_RS03975	COG0745	RESPONSE REGULATOR receiver
CN03_RS03980	COG3118	belongs to the thioredoxin family
CN03_RS03990	COG0142	geranyltranstransferase activity
CN03_RS03995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CN03_RS04000	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CN03_RS04005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CN03_RS04010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CN03_RS04015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CN03_RS04020	COG0268	Binds directly to 16S ribosomal RNA
CN03_RS04025	COG0728	peptidoglycan biosynthetic process
CN03_RS04030	COG0196	riboflavin kinase activity
CN03_RS04035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CN03_RS04040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CN03_RS04045	COG1047	Peptidyl-prolyl cis-trans
CN03_RS04050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CN03_RS04100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CN03_RS04100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CN03_RS04120	COG0028	Belongs to the TPP enzyme family
CN03_RS04130	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CN03_RS04135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CN03_RS04140	COG0784	Response regulator, receiver
CN03_RS04140	COG2205	protein histidine kinase activity
CN03_RS04140	COG2198	Histidine kinase
CN03_RS04145	COG0151	Belongs to the GarS family
CN03_RS04150	COG0138	bifunctional purine biosynthesis protein purh
CN03_RS04170	COG2264	protein methyltransferase activity
CN03_RS04175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CN03_RS04185	COG5001	Diguanylate cyclase
CN03_RS04185	COG3300	MHYT domain
CN03_RS04195	COG2863	cytochrome
CN03_RS04210	COG0488	(ABC) transporter
CN03_RS04215	COG3706	GGDEF domain
CN03_RS04235	COG0737	Belongs to the 5'-nucleotidase family
CN03_RS04240	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CN03_RS04245	COG3239	Fatty acid desaturase
CN03_RS04255	COG0741	lytic transglycosylase activity
CN03_RS04260	COG2096	Adenosyltransferase
CN03_RS04265	COG4206	TonB-dependent receptor
CN03_RS04270	COG5002	protein histidine kinase activity
CN03_RS04275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CN03_RS04285	COG1666	GTP binding
CN03_RS04290	COG2211	Major facilitator Superfamily
CN03_RS04295	COG0587	DNA-directed DNA polymerase activity
CN03_RS04315	COG0583	DNA-binding transcription factor activity
CN03_RS04335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CN03_RS04350	COG0300	oxidoreductase activity
CN03_RS04365	COG0415	Belongs to the DNA photolyase family
CN03_RS04370	COG0789	Transcriptional regulator
CN03_RS04375	COG3272	Protein of unknown function (DUF1722)
CN03_RS04385	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CN03_RS04390	COG1960	acyl-CoA dehydrogenase activity
CN03_RS04395	COG1090	epimerase
CN03_RS04435	COG0069	glutamate synthase activity
CN03_RS04440	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CN03_RS04460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CN03_RS04465	COG0415	Belongs to the DNA photolyase family
CN03_RS04475	COG3046	protein related to deoxyribodipyrimidine photolyase
CN03_RS04480	COG1024	Enoyl-CoA hydratase
CN03_RS04480	COG1250	3-hydroxyacyl-CoA dehydrogenase
CN03_RS04485	COG1960	acyl-CoA dehydrogenase activity
CN03_RS04490	COG1454	alcohol dehydrogenase
CN03_RS04495	COG0824	Thioesterase
CN03_RS04500	COG1012	belongs to the aldehyde dehydrogenase family
CN03_RS04520	COG3128	pkhd-type hydroxylase
CN03_RS04545	COG0848	biopolymer transport protein
CN03_RS04550	COG0811	peptide transport
CN03_RS04555	COG4251	negative regulation of phosphorylation
CN03_RS04555	COG3706	GGDEF domain
CN03_RS04555	COG2203	Gaf domain
CN03_RS04555	COG5001	Diguanylate cyclase
CN03_RS04560	COG4251	negative regulation of phosphorylation
CN03_RS04560	COG5001	Diguanylate cyclase
CN03_RS04560	COG3706	GGDEF domain
CN03_RS04560	COG2203	Gaf domain
CN03_RS04565	COG5001	Diguanylate cyclase
CN03_RS04565	COG4251	negative regulation of phosphorylation
CN03_RS04565	COG3706	GGDEF domain
CN03_RS04565	COG2203	Gaf domain
CN03_RS04570	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CN03_RS04580	COG3586	endonuclease activity
CN03_RS04610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CN03_RS04615	COG0733	neurotransmitter:sodium symporter activity
CN03_RS04625	COG2914	Belongs to the UPF0125 (RnfH) family
CN03_RS04640	COG0497	DNA recombination
CN03_RS04645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CN03_RS04650	COG0443	Heat shock 70 kDa protein
CN03_RS04655	COG0484	heat shock protein binding
CN03_RS04660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CN03_RS04685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CN03_RS04700	COG1607	acyl-coa hydrolase
CN03_RS04715	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CN03_RS04720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CN03_RS04725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CN03_RS04730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CN03_RS04735	COG0149	triose-phosphate isomerase activity
CN03_RS04750	COG0779	Required for maturation of 30S ribosomal subunits
CN03_RS04755	COG0195	Participates in both transcription termination and antitermination
CN03_RS04760	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CN03_RS04765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CN03_RS04770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CN03_RS04775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CN03_RS04780	COG1185	polyribonucleotide nucleotidyltransferase activity
CN03_RS04790	COG1404	Belongs to the peptidase S8 family
CN03_RS04810	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CN03_RS04815	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CN03_RS04845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CN03_RS04855	COG1322	Protein conserved in bacteria
CN03_RS04865	COG4106	trans-aconitate 2-methyltransferase activity
CN03_RS04870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CN03_RS04875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CN03_RS04880	COG3630	sodium ion export across plasma membrane
CN03_RS04890	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CN03_RS04910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CN03_RS04910	COG0519	Catalyzes the synthesis of GMP from XMP
CN03_RS04915	COG3530	Putative quorum-sensing-regulated virulence factor
CN03_RS04920	COG3300	MHYT domain
CN03_RS04920	COG5001	Diguanylate cyclase
CN03_RS04925	COG3123	guanosine phosphorylase activity
CN03_RS04930	COG0513	Belongs to the DEAD box helicase family
CN03_RS04950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CN03_RS04980	COG0784	Response regulator, receiver
CN03_RS04980	COG2198	Histidine kinase
CN03_RS04980	COG5002	protein histidine kinase activity
CN03_RS04995	COG0625	glutathione transferase activity
CN03_RS05000	COG0625	glutathione transferase activity
CN03_RS05010	COG2207	Transcriptional regulator
CN03_RS05015	COG4303	Ethanolamine ammonia lyase large subunit
CN03_RS05025	COG0531	amino acid
CN03_RS05050	COG0210	DNA helicase
CN03_RS05075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CN03_RS05085	COG4191	Histidine kinase
CN03_RS05090	COG0023	Translation Initiation Factor
CN03_RS05110	COG0590	tRNA wobble adenosine to inosine editing
CN03_RS05115	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CN03_RS05130	COG0175	sulfate reduction
CN03_RS05150	COG1283	sodium-dependent phosphate transmembrane transporter activity
CN03_RS05165	COG0228	four-way junction DNA binding
CN03_RS05170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CN03_RS05175	COG0336	Belongs to the RNA methyltransferase TrmD family
CN03_RS05180	COG0335	large ribosomal subunit rRNA binding
CN03_RS05185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CN03_RS05190	COG0564	pseudouridine synthase activity
CN03_RS05205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CN03_RS05205	COG4651	solute:proton antiporter activity
CN03_RS05215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CN03_RS05240	COG0492	ferredoxin-NADP+ reductase activity
CN03_RS05250	COG0393	Putative heavy-metal-binding
CN03_RS05255	COG0393	Putative heavy-metal-binding
CN03_RS05260	COG1960	acyl-CoA dehydrogenase activity
CN03_RS05300	COG2856	Zn peptidase
CN03_RS05365	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CN03_RS05370	COG0784	Response regulator, receiver
CN03_RS05370	COG0835	chemotaxis
CN03_RS05380	COG1815	bacterial-type flagellum-dependent cell motility
CN03_RS05390	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CN03_RS05400	COG4787	bacterial-type flagellum-dependent cell motility
CN03_RS05405	COG4786	Flagellar basal body rod
CN03_RS05410	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CN03_RS05415	COG1706	bacterial-type flagellum-dependent cell motility
CN03_RS05445	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CN03_RS05460	COG0529	Catalyzes the synthesis of activated sulfate
CN03_RS05500	COG0438	transferase activity, transferring glycosyl groups
CN03_RS05510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CN03_RS05515	COG1051	belongs to the nudix hydrolase family
CN03_RS05520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CN03_RS05580	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CN03_RS05600	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CN03_RS05620	COG1596	polysaccharide export
CN03_RS05625	COG0489	protein tyrosine kinase activity
CN03_RS05645	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CN03_RS05660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CN03_RS05665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CN03_RS05670	COG2890	protein-(glutamine-N5) methyltransferase activity
CN03_RS05700	COG1677	Flagellar hook-basal body complex protein FliE
CN03_RS05735	COG0745	RESPONSE REGULATOR receiver
CN03_RS05740	COG0643	Histidine kinase
CN03_RS05740	COG2198	Histidine kinase
CN03_RS05745	COG0835	chemotaxis
CN03_RS05750	COG0840	transmembrane signaling receptor activity
CN03_RS05760	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CN03_RS05815	COG1987	bacterial-type flagellum assembly
CN03_RS05820	COG1684	flagellar biosynthetic protein fliR
CN03_RS05825	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CN03_RS05860	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CN03_RS05865	COG2198	Histidine kinase
CN03_RS05865	COG0784	Response regulator, receiver
CN03_RS05865	COG0643	Histidine kinase
CN03_RS05870	COG2201	protein-glutamate methylesterase activity
CN03_RS05875	COG1192	Involved in chromosome partitioning
CN03_RS05890	COG0835	chemotaxis
CN03_RS05925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CN03_RS05930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CN03_RS05940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CN03_RS05945	COG0745	RESPONSE REGULATOR receiver
CN03_RS05950	COG2205	protein histidine kinase activity
CN03_RS05955	COG0583	DNA-binding transcription factor activity
CN03_RS05960	COG0840	transmembrane signaling receptor activity
CN03_RS05965	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CN03_RS05975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CN03_RS05980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CN03_RS05985	COG0189	ligase activity
CN03_RS06005	COG0604	alcohol dehydrogenase
CN03_RS06005	COG3321	synthase
CN03_RS06010	COG0602	queuosine metabolic process
CN03_RS06015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CN03_RS06045	COG0513	Belongs to the DEAD box helicase family
CN03_RS06050	COG1741	Belongs to the pirin family
CN03_RS06055	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CN03_RS06060	COG0024	Methionine aminopeptidase
CN03_RS06065	COG0052	Belongs to the universal ribosomal protein uS2 family
CN03_RS06070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CN03_RS06075	COG0528	UMP kinase activity
CN03_RS06080	COG0233	cytoplasmic translational termination
CN03_RS06085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CN03_RS06120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CN03_RS06125	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CN03_RS06130	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CN03_RS06135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CN03_RS06145	COG2081	HI0933 family
CN03_RS06175	COG1017	nitric oxide dioxygenase activity
CN03_RS06175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CN03_RS06190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CN03_RS06195	COG1024	Enoyl-CoA hydratase
CN03_RS06200	COG0439	Biotin carboxylase
CN03_RS06215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CN03_RS06220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CN03_RS06240	COG0864	Transcriptional regulator
CN03_RS06260	COG0436	Aminotransferase
CN03_RS06285	COG1187	pseudouridine synthase activity
CN03_RS06290	COG0676	glucose-6-phosphate 1-epimerase activity
CN03_RS06295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CN03_RS06305	COG3112	Uncharacterised protein family (UPF0231)
CN03_RS06310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CN03_RS06315	COG0418	dihydroorotase activity
CN03_RS06325	COG0137	argininosuccinate synthase activity
CN03_RS06350	COG2801	Transposase and inactivated derivatives
CN03_RS06365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CN03_RS06375	COG0564	pseudouridine synthase activity
CN03_RS06405	COG1451	nucleotide metabolic process
CN03_RS06415	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CN03_RS06415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CN03_RS06420	COG0583	DNA-binding transcription factor activity
CN03_RS06430	COG1846	Transcriptional regulator
CN03_RS06435	COG0697	spore germination
CN03_RS06460	COG0346	lactoylglutathione lyase activity
CN03_RS06465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CN03_RS06475	COG2885	chlorophyll binding
CN03_RS06480	COG2171	N-acyltransferase activity
CN03_RS06485	COG1393	Belongs to the ArsC family
CN03_RS06490	COG0784	Response regulator, receiver
CN03_RS06490	COG2205	protein histidine kinase activity
CN03_RS06490	COG5002	protein histidine kinase activity
CN03_RS06500	COG0400	carboxylic ester hydrolase activity
CN03_RS06520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CN03_RS06525	COG0719	Fe-S assembly protein
CN03_RS06530	COG0396	ATPase activity
CN03_RS06535	COG0719	Fe-S assembly protein
CN03_RS06550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CN03_RS06590	COG1285	pathogenesis
CN03_RS06595	COG0443	Heat shock 70 kDa protein
CN03_RS06615	COG0840	transmembrane signaling receptor activity
CN03_RS06640	COG1393	Belongs to the ArsC family
CN03_RS06645	COG1295	ribonuclease BN
CN03_RS06685	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CN03_RS06705	COG3243	poly(R)-hydroxyalkanoic acid synthase
CN03_RS06720	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CN03_RS06720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CN03_RS06730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CN03_RS06745	COG2350	Protein conserved in bacteria
CN03_RS06750	COG2917	probably involved in intracellular septation
CN03_RS06755	COG0613	PHP domain protein
CN03_RS06760	COG0009	L-threonylcarbamoyladenylate synthase
CN03_RS06765	COG0180	Tryptophanyl-tRNA synthetase
CN03_RS06770	COG0180	Tryptophanyl-tRNA synthetase
CN03_RS06780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CN03_RS06790	COG3706	GGDEF domain
CN03_RS06795	COG1028	Short-chain dehydrogenase reductase Sdr
CN03_RS06805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CN03_RS06810	COG0402	S-adenosylhomocysteine deaminase activity
CN03_RS06825	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CN03_RS06835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CN03_RS06840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CN03_RS06845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CN03_RS06855	COG0776	regulation of translation
CN03_RS06860	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CN03_RS06865	COG0284	orotidine-5'-phosphate decarboxylase activity
CN03_RS06905	COG0438	transferase activity, transferring glycosyl groups
CN03_RS06925	COG2801	Transposase and inactivated derivatives
CN03_RS06950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CN03_RS06955	COG0717	Belongs to the dCTP deaminase family
CN03_RS06965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CN03_RS06985	COG0436	Aminotransferase
CN03_RS06990	COG0556	nucleotide-excision repair
CN03_RS07005	COG5001	Diguanylate cyclase
CN03_RS07005	COG4251	negative regulation of phosphorylation
CN03_RS07005	COG3706	GGDEF domain
CN03_RS07005	COG2203	Gaf domain
CN03_RS07025	COG0737	Belongs to the 5'-nucleotidase family
CN03_RS07030	COG3850	Histidine kinase
CN03_RS07035	COG2197	response regulator
CN03_RS07045	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CN03_RS07050	COG0732	type I restriction modification DNA specificity domain
CN03_RS07070	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CN03_RS07100	COG0709	Synthesizes selenophosphate from selenide and ATP
CN03_RS07105	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CN03_RS07110	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CN03_RS07120	COG3639	organic phosphonate transmembrane transporter activity
CN03_RS07150	COG1045	serine acetyltransferase
CN03_RS07155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CN03_RS07165	COG0318	PFAM AMP-dependent synthetase and ligase
CN03_RS07170	COG1215	transferase activity, transferring glycosyl groups
CN03_RS07190	COG1045	serine acetyltransferase
CN03_RS07260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CN03_RS07265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CN03_RS07270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CN03_RS07275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CN03_RS07280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CN03_RS07285	COG0072	phenylalanine-tRNA ligase activity
CN03_RS07290	COG0776	regulation of translation
CN03_RS07320	COG2801	Transposase and inactivated derivatives
CN03_RS07400	COG1136	(ABC) transporter
CN03_RS07400	COG0577	efflux transmembrane transporter activity
CN03_RS07405	COG1136	(ABC) transporter
CN03_RS07405	COG0577	efflux transmembrane transporter activity
CN03_RS07410	COG1136	(ABC) transporter
CN03_RS07410	COG0577	efflux transmembrane transporter activity
CN03_RS07415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CN03_RS07430	COG0500	methyltransferase
CN03_RS07435	COG3122	Protein conserved in bacteria
CN03_RS07440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CN03_RS07445	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CN03_RS07450	COG2205	protein histidine kinase activity
CN03_RS07450	COG2202	Pas domain
CN03_RS07455	COG0318	PFAM AMP-dependent synthetase and ligase
CN03_RS07460	COG1960	acyl-CoA dehydrogenase activity
CN03_RS07465	COG1960	acyl-CoA dehydrogenase activity
CN03_RS07470	COG3022	response to hydroperoxide
CN03_RS07490	COG0583	DNA-binding transcription factor activity
CN03_RS07500	COG0542	response to heat
CN03_RS07510	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CN03_RS07515	COG0632	four-way junction helicase activity
CN03_RS07520	COG2255	four-way junction helicase activity
CN03_RS07525	COG0824	Thioesterase
CN03_RS07545	COG0823	Involved in the tonB-independent uptake of proteins
CN03_RS07550	COG2885	chlorophyll binding
CN03_RS07555	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CN03_RS07570	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CN03_RS07575	COG4783	chaperone-mediated protein folding
CN03_RS07590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CN03_RS07605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CN03_RS07620	COG4269	membrane
CN03_RS07635	COG0545	Peptidyl-prolyl cis-trans isomerase
CN03_RS07660	COG0363	glucosamine-6-phosphate deaminase activity
CN03_RS07670	COG0800	Aldolase
CN03_RS07690	COG1215	transferase activity, transferring glycosyl groups
CN03_RS07695	COG3769	mannosylglycerate metabolic process
CN03_RS07700	COG0572	uridine kinase
CN03_RS07705	COG1605	Chorismate mutase
CN03_RS07705	COG0077	Prephenate dehydratase
CN03_RS07710	COG0784	Response regulator, receiver
CN03_RS07710	COG5002	protein histidine kinase activity
CN03_RS07710	COG2205	protein histidine kinase activity
CN03_RS07730	COG3437	response regulator, receiver
CN03_RS07750	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CN03_RS07765	COG2022	thiamine diphosphate biosynthetic process
CN03_RS07770	COG0352	thiamine-phosphate diphosphorylase activity
CN03_RS07775	COG0326	Molecular chaperone. Has ATPase activity
CN03_RS07800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CN03_RS07810	COG1376	ErfK ybiS ycfS ynhG family protein
CN03_RS07815	COG1472	Belongs to the glycosyl hydrolase 3 family
CN03_RS07840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CN03_RS07850	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CN03_RS07855	COG1805	sodium ion transport
CN03_RS07875	COG2871	sodium ion transport
CN03_RS07885	COG3179	chitinase
CN03_RS07945	COG4372	Transposase
CN03_RS08055	COG3268	Saccharopine dehydrogenase
CN03_RS08060	COG0640	Transcriptional regulator
CN03_RS08070	COG0798	PFAM Bile acid sodium symporter
CN03_RS08095	COG3012	SEC-C Motif Domain Protein
CN03_RS08100	COG0513	Belongs to the DEAD box helicase family
CN03_RS08135	COG3239	Fatty acid desaturase
CN03_RS08150	COG1960	acyl-CoA dehydrogenase activity
CN03_RS08160	COG3047	cAMP biosynthetic process
CN03_RS08170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CN03_RS08175	COG0302	gtp cyclohydrolase
CN03_RS08180	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CN03_RS08185	COG3706	GGDEF domain
CN03_RS08205	COG0640	Transcriptional regulator
CN03_RS08235	COG0271	Belongs to the BolA IbaG family
CN03_RS08265	COG0484	heat shock protein binding
CN03_RS08275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CN03_RS08285	COG0037	tRNA processing
CN03_RS08295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CN03_RS08325	COG2010	Cytochrome c
CN03_RS08340	COG3278	Belongs to the heme-copper respiratory oxidase family
CN03_RS08385	COG3920	Histidine kinase
CN03_RS08400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CN03_RS08410	COG5002	protein histidine kinase activity
CN03_RS08410	COG2205	protein histidine kinase activity
CN03_RS08410	COG0784	Response regulator, receiver
CN03_RS08425	COG0189	ligase activity
CN03_RS08430	COG0456	acetyltransferase
CN03_RS08450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CN03_RS08465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CN03_RS08485	COG0477	Major facilitator Superfamily
CN03_RS08505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CN03_RS08510	COG3177	Filamentation induced by cAMP protein fic
CN03_RS08520	COG1049	propionate catabolic process, 2-methylcitrate cycle
CN03_RS08530	COG3383	formate dehydrogenase (NAD+) activity
CN03_RS08535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CN03_RS08545	COG0436	Aminotransferase
CN03_RS08550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CN03_RS08555	COG0386	Belongs to the glutathione peroxidase family
CN03_RS08560	COG1846	Transcriptional regulator
CN03_RS08595	COG1131	(ABC) transporter
CN03_RS08600	COG0842	Transport permease protein
CN03_RS08605	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CN03_RS08605	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CN03_RS08630	COG2963	transposase activity
CN03_RS08635	COG2801	Transposase and inactivated derivatives
CN03_RS08685	COG2801	Transposase and inactivated derivatives
CN03_RS08690	COG2963	transposase activity
CN03_RS08710	COG4999	Histidine kinase
CN03_RS08710	COG3850	Histidine kinase
CN03_RS08710	COG3437	response regulator, receiver
CN03_RS08710	COG2205	protein histidine kinase activity
CN03_RS08740	COG0840	transmembrane signaling receptor activity
CN03_RS08745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CN03_RS08760	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CN03_RS08770	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CN03_RS08785	COG2850	peptidyl-arginine hydroxylation
CN03_RS08815	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CN03_RS08830	COG3267	Type II secretory pathway component ExeA
CN03_RS08830	COG3409	Peptidoglycan-binding domain 1 protein
CN03_RS08840	COG1199	ATP-dependent helicase activity
CN03_RS08855	COG4591	ABC-type transport system involved in lipoprotein release permease component
CN03_RS08875	COG0811	peptide transport
CN03_RS08880	COG0848	biopolymer transport protein
CN03_RS08885	COG1132	(ABC) transporter
CN03_RS08890	COG1663	tetraacyldisaccharide 4'-kinase activity
CN03_RS08895	COG2835	tetraacyldisaccharide 4'-kinase activity
CN03_RS08900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CN03_RS08910	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CN03_RS08915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CN03_RS08920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CN03_RS08925	COG0215	cysteine-tRNA ligase activity
CN03_RS08990	COG2860	membrane
CN03_RS09000	COG3177	Filamentation induced by cAMP protein fic
CN03_RS09010	COG2133	pyrroloquinoline quinone binding
CN03_RS09015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CN03_RS09035	COG0544	peptidyl-prolyl cis-trans isomerase activity
CN03_RS09040	COG0740	serine-type endopeptidase activity
CN03_RS09045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CN03_RS09050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CN03_RS09065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CN03_RS09080	COG1388	LysM domain
CN03_RS09080	COG0741	lytic transglycosylase activity
CN03_RS09090	COG0328	RNA-DNA hybrid ribonuclease activity
CN03_RS09095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CN03_RS09100	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CN03_RS09120	COG0616	signal peptide processing
CN03_RS09125	COG0604	alcohol dehydrogenase
CN03_RS09130	COG4651	solute:proton antiporter activity
CN03_RS09130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CN03_RS09140	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CN03_RS09145	COG0584	glycerophosphoryl diester phosphodiesterase
CN03_RS09150	COG0534	Mate efflux family protein
CN03_RS09160	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CN03_RS09160	COG0316	Belongs to the HesB IscA family
CN03_RS09170	COG0745	RESPONSE REGULATOR receiver
CN03_RS09180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CN03_RS09190	COG2062	phosphohistidine phosphatase, SixA
CN03_RS09210	COG0564	pseudouridine synthase activity
CN03_RS09215	COG0826	peptidase U32
CN03_RS09250	COG1477	protein flavinylation
CN03_RS09260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CN03_RS09275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CN03_RS09280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CN03_RS09290	COG2915	High frequency lysogenization protein hflD homolog
CN03_RS09305	COG1187	pseudouridine synthase activity
CN03_RS09315	COG1278	Cold shock
CN03_RS09320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CN03_RS09325	COG0542	response to heat
CN03_RS09330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CN03_RS09335	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CN03_RS09340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CN03_RS09345	COG1674	ftsk spoiiie
CN03_RS09350	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CN03_RS09355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CN03_RS09360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CN03_RS09365	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CN03_RS09370	COG1648	precorrin-2 dehydrogenase activity
CN03_RS09370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CN03_RS09380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CN03_RS09385	COG2920	part of a sulfur-relay system
CN03_RS09395	COG2923	Belongs to the DsrF TusC family
CN03_RS09400	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CN03_RS09410	COG0123	including yeast histone deacetylase and acetoin utilization protein
CN03_RS09415	COG1042	CoA-binding domain protein
CN03_RS09415	COG0045	succinate-CoA ligase (ADP-forming) activity
CN03_RS09415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CN03_RS09420	COG2197	response regulator
CN03_RS09425	COG0322	excinuclease ABC activity
CN03_RS09430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CN03_RS09515	COG3156	type II secretion system protein K
CN03_RS09535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CN03_RS09585	COG2326	polyphosphate kinase activity
CN03_RS09595	COG0723	plastoquinol--plastocyanin reductase activity
CN03_RS09600	COG0058	SHG alpha-glucan phosphorylase activity
CN03_RS09640	COG2217	Heavy metal translocating P-type atpase
CN03_RS09685	COG5002	protein histidine kinase activity
CN03_RS09710	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CN03_RS09715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CN03_RS09800	COG1028	Short-chain dehydrogenase reductase Sdr
CN03_RS09805	COG0301	tRNA thio-modification
CN03_RS09805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CN03_RS09820	COG4372	Transposase
CN03_RS09835	COG0708	Exodeoxyribonuclease III
CN03_RS09855	COG0848	biopolymer transport protein
CN03_RS09860	COG0811	peptide transport
CN03_RS09865	COG0811	peptide transport
CN03_RS09880	COG1104	cysteine desulfurase activity
CN03_RS09900	COG0666	response to abiotic stimulus
CN03_RS09925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CN03_RS09930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CN03_RS09935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CN03_RS09940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CN03_RS09945	COG1028	Short-chain dehydrogenase reductase Sdr
CN03_RS09955	COG0416	fatty acid biosynthetic process
CN03_RS09960	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CN03_RS09970	COG0616	signal peptide processing
CN03_RS09975	COG0546	phosphoglycolate phosphatase activity
CN03_RS09985	COG1530	ribonuclease E activity
CN03_RS10010	COG0372	Belongs to the citrate synthase family
CN03_RS10015	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CN03_RS10050	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CN03_RS10090	COG0560	Phosphoserine phosphatase
CN03_RS10105	COG0730	response to heat
CN03_RS10125	COG2853	Lipoprotein
CN03_RS10135	COG3220	belongs to the UPF0276 family
CN03_RS10145	COG1643	Atp-dependent helicase
CN03_RS10150	COG0318	PFAM AMP-dependent synthetase and ligase
CN03_RS10155	COG2030	dehydratase
CN03_RS10245	COG2983	Belongs to the UPF0260 family
CN03_RS10250	COG3100	YcgL domain-containing protein
CN03_RS10260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CN03_RS10265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CN03_RS10270	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CN03_RS10285	COG1067	ATP-dependent peptidase activity
CN03_RS10290	COG2205	protein histidine kinase activity
CN03_RS10290	COG0784	Response regulator, receiver
CN03_RS10290	COG2198	Histidine kinase
CN03_RS10320	COG0824	Thioesterase
CN03_RS10325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CN03_RS10330	COG5265	(ABC) transporter
CN03_RS10360	COG3101	peptidyl-lysine hydroxylation
CN03_RS10365	COG0534	Mate efflux family protein
CN03_RS10375	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CN03_RS10430	COG0667	Aldo Keto reductase
CN03_RS10435	COG0840	transmembrane signaling receptor activity
CN03_RS10460	COG0714	Associated with various cellular activities
CN03_RS10475	COG1286	toxin biosynthetic process
CN03_RS10485	COG0285	dihydrofolate synthase activity
CN03_RS10490	COG0159	tryptophan synthase activity
CN03_RS10495	COG0133	tryptophan synthase activity
CN03_RS10500	COG0135	phosphoribosylanthranilate isomerase activity
CN03_RS10515	COG0101	tRNA pseudouridine synthase activity
CN03_RS10530	COG0473	3-isopropylmalate dehydrogenase activity
CN03_RS10540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CN03_RS10550	COG0589	response to stress
CN03_RS10555	COG0280	phosphate acetyltransferase
CN03_RS10560	COG1473	amidohydrolase
CN03_RS10565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CN03_RS10570	COG0006	proline dipeptidase activity
CN03_RS10575	COG1012	belongs to the aldehyde dehydrogenase family
CN03_RS10580	COG0431	NADPH-dependent FMN reductase
CN03_RS10595	COG1741	Belongs to the pirin family
CN03_RS10600	COG0589	response to stress
CN03_RS10650	COG2801	Transposase and inactivated derivatives
CN03_RS10685	COG0045	succinate-CoA ligase (ADP-forming) activity
CN03_RS10690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CN03_RS10710	COG1053	succinate dehydrogenase
CN03_RS10715	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CN03_RS10730	COG2084	Dehydrogenase
CN03_RS10740	COG0835	chemotaxis
CN03_RS10740	COG0784	Response regulator, receiver
CN03_RS10745	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CN03_RS10750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CN03_RS10760	COG0859	PFAM glycosyl transferase family 9
CN03_RS10770	COG0463	Glycosyl transferase, family 2
CN03_RS10790	COG0439	Biotin carboxylase
CN03_RS10800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CN03_RS10805	COG1074	ATP-dependent DNA helicase activity
CN03_RS10810	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CN03_RS10865	COG0686	Belongs to the AlaDH PNT family
CN03_RS10875	COG4773	Receptor
CN03_RS10905	COG3707	response regulator
CN03_RS10910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CN03_RS10910	COG1116	anion transmembrane transporter activity
CN03_RS10915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CN03_RS10925	COG1116	anion transmembrane transporter activity
CN03_RS10935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CN03_RS10945	COG0515	serine threonine protein kinase
CN03_RS10945	COG2815	serine threonine protein kinase
CN03_RS10950	COG2223	nitrite transmembrane transporter activity
CN03_RS10960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CN03_RS10965	COG0243	molybdopterin cofactor binding
CN03_RS10970	COG1648	precorrin-2 dehydrogenase activity
CN03_RS10970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CN03_RS11035	COG2818	Glycosylase
CN03_RS11045	COG0442	prolyl-tRNA aminoacylation
CN03_RS11085	COG0579	oxidoreductase
CN03_RS11150	COG2205	protein histidine kinase activity
CN03_RS11155	COG1902	pentaerythritol trinitrate reductase activity
CN03_RS11155	COG0446	pyridine nucleotide-disulphide oxidoreductase
CN03_RS11160	COG0489	protein tyrosine kinase activity
CN03_RS11165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CN03_RS11175	COG4172	Belongs to the ABC transporter superfamily
CN03_RS11180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CN03_RS11185	COG0601	transmembrane transport
CN03_RS11200	COG4657	Part of a membrane complex involved in electron transport
CN03_RS11205	COG2878	Part of a membrane complex involved in electron transport
CN03_RS11210	COG4656	Part of a membrane complex involved in electron transport
CN03_RS11215	COG4658	electron transport chain
CN03_RS11220	COG4659	FMN binding
CN03_RS11225	COG4660	Part of a membrane complex involved in electron transport
CN03_RS11235	COG1054	Belongs to the UPF0176 family
CN03_RS11265	COG1309	transcriptional regulator
CN03_RS11280	COG0840	transmembrane signaling receptor activity
CN03_RS11310	COG2801	Transposase and inactivated derivatives
CN03_RS11335	COG0154	amidase activity
CN03_RS11350	COG1187	pseudouridine synthase activity
CN03_RS11355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CN03_RS11370	COG0789	Transcriptional regulator
CN03_RS11380	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CN03_RS11435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CN03_RS11440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CN03_RS11490	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CN03_RS11500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CN03_RS11505	COG2226	methyltransferase
CN03_RS11520	COG0525	valine-tRNA ligase activity
CN03_RS11570	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
CN03_RS11590	COG4807	Protein conserved in bacteria
CN03_RS11605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CN03_RS11610	COG0525	valine-tRNA ligase activity
CN03_RS11630	COG0583	DNA-binding transcription factor activity
CN03_RS11640	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CN03_RS11655	COG1862	Preprotein translocase
CN03_RS11660	COG0343	queuine tRNA-ribosyltransferase activity
CN03_RS11685	COG3706	GGDEF domain
CN03_RS11685	COG4251	negative regulation of phosphorylation
CN03_RS11685	COG5001	Diguanylate cyclase
CN03_RS11685	COG2203	Gaf domain
CN03_RS11700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CN03_RS11730	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CN03_RS11735	COG2945	thiolester hydrolase activity
CN03_RS11740	COG0175	sulfate reduction
CN03_RS11765	COG3001	Fructosamine kinase
CN03_RS11770	COG0259	pyridoxamine-phosphate oxidase activity
CN03_RS11780	COG0795	lipopolysaccharide-transporting ATPase activity
CN03_RS11785	COG0795	lipopolysaccharide-transporting ATPase activity
CN03_RS11790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CN03_RS11805	COG2885	chlorophyll binding
CN03_RS11810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CN03_RS11810	COG0519	Catalyzes the synthesis of GMP from XMP
CN03_RS11835	COG1570	exodeoxyribonuclease VII activity
CN03_RS11840	COG0739	heme binding
CN03_RS11855	COG1946	Acyl-CoA thioesterase
CN03_RS11860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CN03_RS11865	COG0513	Belongs to the DEAD box helicase family
CN03_RS11890	COG1131	(ABC) transporter
CN03_RS11915	COG1741	Belongs to the pirin family
CN03_RS11925	COG2818	Glycosylase
CN03_RS11935	COG2925	Exonuclease
CN03_RS11940	COG2267	carboxylic ester hydrolase activity
CN03_RS11960	COG2223	nitrite transmembrane transporter activity
CN03_RS11970	COG1028	Short-chain dehydrogenase reductase Sdr
CN03_RS11975	COG0517	IMP dehydrogenase activity
CN03_RS11975	COG0516	GMP reductase activity
CN03_RS11990	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CN03_RS12000	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CN03_RS12000	COG3264	Mechanosensitive ion channel
CN03_RS12020	COG1643	Atp-dependent helicase
CN03_RS12025	COG2184	nucleotidyltransferase activity
CN03_RS12040	COG2801	Transposase and inactivated derivatives
CN03_RS12050	COG4115	mRNA cleavage
CN03_RS12055	COG2161	toxin-antitoxin pair type II binding
CN03_RS12095	COG0307	riboflavin synthase, alpha
CN03_RS12150	COG0657	acetylesterase activity
CN03_RS12155	COG0004	ammonium transporteR
CN03_RS12165	COG3130	regulation of translation
CN03_RS12190	COG0714	Associated with various cellular activities
CN03_RS12205	COG2304	oxidoreductase activity
CN03_RS12255	COG0519	Catalyzes the synthesis of GMP from XMP
CN03_RS12260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CN03_RS12265	COG3115	cell septum assembly
CN03_RS12270	COG1196	nuclear chromosome segregation
CN03_RS12280	COG3239	Fatty acid desaturase
CN03_RS12300	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CN03_RS12305	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CN03_RS12305	COG0493	'glutamate synthase
CN03_RS12315	COG1902	pentaerythritol trinitrate reductase activity
CN03_RS12340	COG1028	Short-chain dehydrogenase reductase Sdr
CN03_RS12370	COG0456	acetyltransferase
CN03_RS12375	COG2801	Transposase and inactivated derivatives
CN03_RS12390	COG2801	Transposase and inactivated derivatives
CN03_RS12420	COG2801	Transposase and inactivated derivatives
CN03_RS12455	COG0183	Belongs to the thiolase family
CN03_RS12460	COG1250	3-hydroxyacyl-CoA dehydrogenase
CN03_RS12460	COG1024	Enoyl-CoA hydratase
CN03_RS12475	COG0488	(ABC) transporter
CN03_RS12480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CN03_RS12530	COG2409	Drug exporters of the RND superfamily
CN03_RS12545	COG0308	aminopeptidase N
CN03_RS12560	COG0705	Rhomboid family
CN03_RS12565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CN03_RS12570	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CN03_RS12645	COG0494	nUDIX hydrolase
CN03_RS12670	COG0681	Belongs to the peptidase S26 family
CN03_RS12675	COG0596	Alpha beta hydrolase
CN03_RS12680	COG1253	flavin adenine dinucleotide binding
CN03_RS12695	COG2095	MarC family integral membrane protein
CN03_RS12710	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CN03_RS12735	COG2200	EAL domain
CN03_RS12735	COG2199	diguanylate cyclase activity
CN03_RS12735	COG2202	Pas domain
CN03_RS12765	COG0784	Response regulator, receiver
CN03_RS12765	COG2205	protein histidine kinase activity
CN03_RS12775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CN03_RS12805	COG2885	chlorophyll binding
CN03_RS12825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CN03_RS12830	COG1138	Cytochrome C-type biogenesis protein
CN03_RS12850	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CN03_RS12855	COG4133	protoheme IX ABC transporter activity
CN03_RS12875	COG0252	asparaginase activity
CN03_RS12915	COG5001	Diguanylate cyclase
CN03_RS12915	COG2203	Gaf domain
CN03_RS12915	COG3706	GGDEF domain
CN03_RS12915	COG4251	negative regulation of phosphorylation
CN03_RS12930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CN03_RS12940	COG0204	Acyl-transferase
CN03_RS12945	COG2203	Gaf domain
CN03_RS12945	COG3706	GGDEF domain
CN03_RS12945	COG4251	negative regulation of phosphorylation
CN03_RS12945	COG5001	Diguanylate cyclase
CN03_RS12965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CN03_RS12995	COG2205	protein histidine kinase activity
CN03_RS12995	COG0784	Response regulator, receiver
CN03_RS12995	COG5002	protein histidine kinase activity
CN03_RS13005	COG4753	response regulator
CN03_RS13005	COG2207	Transcriptional regulator
CN03_RS13015	COG1025	Belongs to the peptidase M16 family
CN03_RS13030	COG0300	oxidoreductase activity
CN03_RS13060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CN03_RS13065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CN03_RS13075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CN03_RS13090	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CN03_RS13120	COG2264	protein methyltransferase activity
CN03_RS13140	COG0084	hydrolase, TatD family'
CN03_RS13175	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CN03_RS13195	COG1278	Cold shock
CN03_RS13200	COG3313	Fe-S protein
CN03_RS13205	COG3622	Belongs to the hyi family
CN03_RS13210	COG2084	Dehydrogenase
CN03_RS13215	COG1639	'signal transduction protein
CN03_RS13230	COG4067	protein conserved in archaea
CN03_RS13230	COG0189	ligase activity
CN03_RS13235	COG2193	ferroxidase activity
CN03_RS13290	COG4804	nuclease activity
CN03_RS13295	COG0732	type I restriction modification DNA specificity domain
CN03_RS13315	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CN03_RS13325	COG0432	Pfam Uncharacterised protein family UPF0047
CN03_RS13335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CN03_RS13345	COG4536	flavin adenine dinucleotide binding
CN03_RS13350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CN03_RS13350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CN03_RS13355	COG0829	nickel cation binding
CN03_RS13360	COG0831	urea catabolic process
CN03_RS13365	COG0832	Belongs to the urease beta subunit family
CN03_RS13370	COG0804	urea catabolic process
CN03_RS13375	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CN03_RS13380	COG0830	nickel cation binding
CN03_RS13385	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CN03_RS13420	COG1960	acyl-CoA dehydrogenase activity
CN03_RS13425	COG1024	Enoyl-CoA hydratase
CN03_RS13425	COG1250	3-hydroxyacyl-CoA dehydrogenase
CN03_RS13430	COG1160	GTP binding
CN03_RS13445	COG0124	histidyl-tRNA synthetase
CN03_RS13460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CN03_RS13465	COG0105	UTP biosynthetic process
CN03_RS13500	COG2900	Belongs to the SlyX family
CN03_RS13505	COG2937	Belongs to the GPAT DAPAT family
CN03_RS13515	COG1968	undecaprenyl-diphosphatase activity
CN03_RS13520	COG1214	PFAM Peptidase M22, glycoprotease
CN03_RS13530	COG0563	adenylate kinase activity
CN03_RS13535	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CN03_RS13540	COG3956	TIGRFAM MazG family protein
CN03_RS13545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CN03_RS13550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CN03_RS13560	COG0784	Response regulator, receiver
CN03_RS13560	COG2205	protein histidine kinase activity
CN03_RS13560	COG5002	protein histidine kinase activity
CN03_RS13565	COG0736	holo-[acyl-carrier-protein] synthase activity
CN03_RS13575	COG1381	Involved in DNA repair and RecF pathway recombination
CN03_RS13580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CN03_RS13585	COG0571	ribonuclease III activity
CN03_RS13595	COG0481	GTPase activity
CN03_RS13600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CN03_RS13650	COG1024	Enoyl-CoA hydratase
CN03_RS13680	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CN03_RS13685	COG0848	biopolymer transport protein
CN03_RS13690	COG0811	peptide transport
CN03_RS13695	COG0811	peptide transport
CN03_RS13715	COG0583	DNA-binding transcription factor activity
CN03_RS13735	COG2067	long-chain fatty acid transport protein
CN03_RS13745	COG0500	methyltransferase
CN03_RS13765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CN03_RS13765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CN03_RS13775	COG0019	diaminopimelate decarboxylase activity
CN03_RS13780	COG1132	(ABC) transporter
CN03_RS13800	COG1024	Enoyl-CoA hydratase
CN03_RS13805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CN03_RS13810	COG2308	Evidence 4 Homologs of previously reported genes of
CN03_RS13840	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CN03_RS13855	COG1597	lipid kinase activity
CN03_RS13865	COG1846	Transcriptional regulator
CN03_RS13905	COG3107	peptidoglycan biosynthetic process
CN03_RS13910	COG0792	nuclease activity
CN03_RS13920	COG0598	Magnesium transport protein CorA
CN03_RS13925	COG0446	pyridine nucleotide-disulphide oxidoreductase
CN03_RS13935	COG2890	protein-(glutamine-N5) methyltransferase activity
CN03_RS13940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CN03_RS13945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CN03_RS13960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CN03_RS13970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CN03_RS13975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CN03_RS13980	COG0193	aminoacyl-tRNA hydrolase activity
CN03_RS13990	COG2814	Major facilitator Superfamily
CN03_RS13995	COG1309	transcriptional regulator
CN03_RS14015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CN03_RS14020	COG1702	phosphate starvation-inducible protein PhoH
CN03_RS14030	COG4535	Mg2 and Co2 transporter CorC
CN03_RS14035	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CN03_RS14060	COG0653	protein targeting
CN03_RS14065	COG0739	heme binding
CN03_RS14070	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CN03_RS14085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CN03_RS14090	COG1181	Belongs to the D-alanine--D-alanine ligase family
CN03_RS14095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CN03_RS14100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CN03_RS14105	COG0772	Belongs to the SEDS family
CN03_RS14115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CN03_RS14120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CN03_RS14125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CN03_RS14140	COG0275	rRNA processing
CN03_RS14195	COG0156	8-amino-7-oxononanoate synthase activity
CN03_RS14200	COG2226	methyltransferase
CN03_RS14205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CN03_RS14220	COG0450	alkyl hydroperoxide reductase
CN03_RS14240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CN03_RS14245	COG0509	glycine decarboxylation via glycine cleavage system
CN03_RS14250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CN03_RS14250	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CN03_RS14255	COG3300	MHYT domain
CN03_RS14255	COG5001	Diguanylate cyclase
CN03_RS14260	COG2203	Gaf domain
CN03_RS14260	COG3706	GGDEF domain
CN03_RS14260	COG4251	negative regulation of phosphorylation
CN03_RS14260	COG5001	Diguanylate cyclase
CN03_RS14295	COG0366	Alpha amylase catalytic
CN03_RS14300	COG0579	oxidoreductase
CN03_RS14305	COG2996	Protein conserved in bacteria
CN03_RS14320	COG4628	conserved protein (DUF2132)
CN03_RS14325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CN03_RS14330	COG0488	(ABC) transporter
CN03_RS14335	COG0840	transmembrane signaling receptor activity
CN03_RS14350	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CN03_RS14380	COG0189	ligase activity
CN03_RS14400	COG0084	hydrolase, TatD family'
CN03_RS14410	COG0513	Belongs to the DEAD box helicase family
CN03_RS14420	COG0025	NhaP-type Na H and K H
CN03_RS14430	COG4628	conserved protein (DUF2132)
CN03_RS14485	COG2072	flavoprotein involved in K transport
CN03_RS14505	COG2268	Band 7 protein
CN03_RS14510	COG1250	3-hydroxyacyl-CoA dehydrogenase
CN03_RS14510	COG1024	Enoyl-CoA hydratase
CN03_RS14515	COG0183	Belongs to the thiolase family
CN03_RS14520	COG1960	acyl-CoA dehydrogenase activity
CN03_RS14525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CN03_RS14530	COG0789	Transcriptional regulator
CN03_RS14535	COG1028	Short-chain dehydrogenase reductase Sdr
CN03_RS14550	COG0840	transmembrane signaling receptor activity
CN03_RS14555	COG0508	dehydrogenase complex catalyzes the overall conversion of
CN03_RS14565	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CN03_RS14580	COG1492	cobalamin metabolic process
CN03_RS14585	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CN03_RS14595	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CN03_RS14610	COG1940	carbohydrate kinase activity
CN03_RS14620	COG3023	N-Acetylmuramoyl-L-alanine amidase
CN03_RS14625	COG1115	amino acid carrier protein
CN03_RS14650	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CN03_RS14655	COG0237	dephospho-CoA kinase activity
CN03_RS14660	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CN03_RS14670	COG2197	response regulator
CN03_RS14685	COG1730	sister chromatid segregation
CN03_RS14715	COG5001	Diguanylate cyclase
CN03_RS14715	COG4251	negative regulation of phosphorylation
CN03_RS14715	COG2203	Gaf domain
CN03_RS14715	COG3706	GGDEF domain
CN03_RS14720	COG1881	PFAM PEBP family protein
CN03_RS14730	COG0678	peroxiredoxin activity
CN03_RS14730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CN03_RS14755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CN03_RS14760	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CN03_RS14795	COG1366	Belongs to the anti-sigma-factor antagonist family
CN03_RS14800	COG0789	Transcriptional regulator
CN03_RS14805	COG2813	Specifically methylates the guanine in position
CN03_RS14810	COG2814	Major facilitator Superfamily
CN03_RS14815	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CN03_RS14820	COG1765	OsmC-like protein
CN03_RS14830	COG0134	indole-3-glycerol-phosphate synthase activity
CN03_RS14835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CN03_RS14865	COG1309	transcriptional regulator
CN03_RS14870	COG1960	acyl-CoA dehydrogenase activity
CN03_RS14875	COG1960	acyl-CoA dehydrogenase activity
CN03_RS14890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CN03_RS14895	COG1040	competence protein
CN03_RS14900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CN03_RS14920	COG2267	carboxylic ester hydrolase activity
CN03_RS14925	COG0183	Belongs to the thiolase family
CN03_RS14930	COG0788	formyltetrahydrofolate deformylase activity
CN03_RS14945	COG1611	Belongs to the LOG family
CN03_RS14955	COG1785	Belongs to the alkaline phosphatase family
CN03_RS14960	COG1785	Belongs to the alkaline phosphatase family
CN03_RS14995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CN03_RS15000	COG0424	maF-like protein
CN03_RS15020	COG2827	Endonuclease containing a URI domain
CN03_RS15025	COG1272	protein, Hemolysin III
CN03_RS15035	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CN03_RS15040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CN03_RS15045	COG3178	'Phosphotransferase
CN03_RS15050	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CN03_RS15055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CN03_RS15060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CN03_RS15065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CN03_RS15075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CN03_RS15080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CN03_RS15085	COG2766	serine protein kinase
CN03_RS15090	COG2718	Belongs to the UPF0229 family
CN03_RS15095	COG2719	SpoVR family
CN03_RS15125	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CN03_RS15125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CN03_RS15130	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CN03_RS15135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CN03_RS15140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CN03_RS15145	COG1610	YqeY-like protein
CN03_RS15150	COG0358	DNA primase activity
CN03_RS15185	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CN03_RS15255	COG2132	Multicopper oxidase
CN03_RS15265	COG0745	RESPONSE REGULATOR receiver
CN03_RS15285	COG1742	UPF0060 membrane protein
CN03_RS15290	COG1230	cation diffusion facilitator family transporter
CN03_RS15325	COG1230	cation diffusion facilitator family transporter
CN03_RS15330	COG0789	Transcriptional regulator
CN03_RS15335	COG0672	)-iron permease
CN03_RS15380	COG4372	Transposase
CN03_RS15405	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CN03_RS15430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CN03_RS15435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CN03_RS15440	COG3177	Filamentation induced by cAMP protein fic
CN03_RS15445	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CN03_RS15475	COG5001	Diguanylate cyclase
CN03_RS15475	COG4251	negative regulation of phosphorylation
CN03_RS15475	COG3706	GGDEF domain
CN03_RS15475	COG2203	Gaf domain
CN03_RS15495	COG1024	Enoyl-CoA hydratase
CN03_RS15520	COG1671	Belongs to the UPF0178 family
CN03_RS15550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CN03_RS15580	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CN03_RS15585	COG0527	aspartate kinase activity
CN03_RS15590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CN03_RS15610	COG2267	carboxylic ester hydrolase activity
CN03_RS15615	COG1252	NADH dehydrogenase
CN03_RS15625	COG2137	regulation of response to DNA damage stimulus
CN03_RS15630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CN03_RS15660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CN03_RS15665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CN03_RS15675	COG0179	Fumarylacetoacetate (FAA) hydrolase
CN03_RS15685	COG0488	(ABC) transporter
CN03_RS15695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CN03_RS15720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CN03_RS15725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CN03_RS15725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CN03_RS15740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CN03_RS15750	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CN03_RS15795	COG2072	flavoprotein involved in K transport
CN03_RS15805	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CN03_RS15810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CN03_RS15815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CN03_RS15825	COG0564	pseudouridine synthase activity
CN03_RS15830	COG2267	carboxylic ester hydrolase activity
CN03_RS15840	COG2267	carboxylic ester hydrolase activity
CN03_RS15865	COG0288	reversible hydration of carbon dioxide
CN03_RS15875	COG0439	Biotin carboxylase
CN03_RS15890	COG1309	transcriptional regulator
CN03_RS15900	COG0546	phosphoglycolate phosphatase activity
CN03_RS15930	COG2409	Drug exporters of the RND superfamily
CN03_RS15945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CN03_RS15960	COG3634	alkyl hydroperoxide reductase activity
CN03_RS15985	COG0668	transmembrane transport
CN03_RS15990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CN03_RS15995	COG0557	exoribonuclease II activity
CN03_RS16005	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CN03_RS16010	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CN03_RS16030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CN03_RS16040	COG0254	rRNA binding
CN03_RS16045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CN03_RS16050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CN03_RS16055	COG2738	Putative neutral zinc metallopeptidase
CN03_RS16060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CN03_RS16065	COG2204	response regulator
CN03_RS16070	COG4191	Histidine kinase
CN03_RS16070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CN03_RS16080	COG0142	geranyltranstransferase activity
CN03_RS16090	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CN03_RS16095	COG1360	Flagellar Motor Protein
CN03_RS16105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CN03_RS16125	COG2212	antiporter activity
CN03_RS16130	COG1863	multisubunit Na H antiporter MnhE subunit
CN03_RS16135	COG0651	ATP synthesis coupled electron transport
CN03_RS16140	COG1006	Multisubunit Na H antiporter MnhC subunit
CN03_RS16145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CN03_RS16145	COG2111	Na H antiporter
CN03_RS16150	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CN03_RS16160	COG0493	'glutamate synthase
CN03_RS16165	COG0069	glutamate synthase activity
CN03_RS16165	COG0067	glutamate synthase
CN03_RS16165	COG0070	glutamate synthase
CN03_RS16175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CN03_RS16215	COG0277	FAD linked oxidase domain protein
CN03_RS16220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CN03_RS16225	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CN03_RS16230	COG1119	ATPase activity
CN03_RS16235	COG0537	adenosine 5'-monophosphoramidase activity
CN03_RS16265	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CN03_RS16270	COG1183	phosphatidylcholine synthase activity
CN03_RS16275	COG0583	DNA-binding transcription factor activity
CN03_RS16280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CN03_RS16285	COG3447	MASE1 domain protein
CN03_RS16285	COG5001	Diguanylate cyclase
CN03_RS16285	COG5002	protein histidine kinase activity
CN03_RS16290	COG0436	Aminotransferase
CN03_RS16295	COG2166	iron-sulfur cluster assembly
CN03_RS16340	COG0126	phosphoglycerate kinase activity
CN03_RS16345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CN03_RS16385	COG0402	S-adenosylhomocysteine deaminase activity
CN03_RS16395	COG2351	hydroxyisourate hydrolase activity
CN03_RS16405	COG4266	Belongs to the allantoicase family
CN03_RS16415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CN03_RS16425	COG3845	ABC transporter
CN03_RS16435	COG1079	Belongs to the binding-protein-dependent transport system permease family
CN03_RS16440	COG1957	nucleoside hydrolase
CN03_RS16445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CN03_RS16460	COG0811	peptide transport
CN03_RS16465	COG0811	peptide transport
CN03_RS16470	COG0848	biopolymer transport protein
CN03_RS16490	COG1309	transcriptional regulator
CN03_RS16510	COG1064	alcohol dehydrogenase
CN03_RS16525	COG2315	Protein conserved in bacteria
CN03_RS16530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CN03_RS16600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CN03_RS16605	COG0360	Binds together with S18 to 16S ribosomal RNA
CN03_RS16640	COG0523	cobalamin synthesis protein
CN03_RS16655	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CN03_RS16670	COG2205	protein histidine kinase activity
CN03_RS16675	COG0745	RESPONSE REGULATOR receiver
CN03_RS16685	COG0517	IMP dehydrogenase activity
CN03_RS16710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CN03_RS16750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CN03_RS16755	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CN03_RS16760	COG0735	belongs to the Fur family
CN03_RS16770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CN03_RS16780	COG0534	Mate efflux family protein
CN03_RS16865	COG1061	Type III restriction enzyme res subunit
CN03_RS16875	COG0534	Mate efflux family protein
CN03_RS16885	COG0583	DNA-binding transcription factor activity
CN03_RS16890	COG3038	cytochrome b561
CN03_RS16895	COG2353	YceI-like domain
CN03_RS16910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CN03_RS16935	COG4890	Cyd operon protein YbgT
CN03_RS16940	COG1294	oxidase, subunit
CN03_RS16955	COG2199	diguanylate cyclase activity
CN03_RS16955	COG2200	EAL domain
CN03_RS16975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CN03_RS16975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CN03_RS16985	COG0203	ribosomal protein L17
CN03_RS16990	COG0202	RNA polymerase activity
CN03_RS16995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CN03_RS17005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CN03_RS17010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CN03_RS17020	COG0200	Binds to the 23S rRNA
CN03_RS17025	COG1841	ribosomal large subunit assembly
CN03_RS17030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CN03_RS17040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CN03_RS17045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CN03_RS17050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CN03_RS17055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CN03_RS17060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CN03_RS17065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CN03_RS17070	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CN03_RS17075	COG0255	Belongs to the universal ribosomal protein uL29 family
CN03_RS17085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CN03_RS17090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CN03_RS17095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CN03_RS17100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CN03_RS17105	COG0089	rRNA binding
CN03_RS17110	COG0088	Forms part of the polypeptide exit tunnel
CN03_RS17120	COG0051	transcription antitermination factor activity, RNA binding
CN03_RS17125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CN03_RS17130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CN03_RS17135	COG0049	tRNA binding
CN03_RS17140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CN03_RS17150	COG0085	RNA polymerase activity
CN03_RS17155	COG0222	ribosome binding
CN03_RS17160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CN03_RS17165	COG0081	regulation of translation
CN03_RS17170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CN03_RS17190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CN03_RS17195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CN03_RS17200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CN03_RS17225	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CN03_RS17230	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CN03_RS17230	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CN03_RS17235	COG4953	penicillin-binding protein 1C
CN03_RS17240	COG2373	Large extracellular alpha-helical protein
CN03_RS17265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CN03_RS17285	COG2169	Transcriptional regulator
CN03_RS17285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CN03_RS17320	COG2801	Transposase and inactivated derivatives
CN03_RS17325	COG2963	transposase activity
CN03_RS17350	COG2963	transposase activity
CN03_RS17355	COG0702	epimerase
CN03_RS17360	COG3038	cytochrome b561
CN03_RS17385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CN03_RS17390	COG1129	ABC transporter
CN03_RS17390	COG0842	Transport permease protein
CN03_RS17395	COG0842	Transport permease protein
CN03_RS17405	COG1028	Short-chain dehydrogenase reductase Sdr
CN03_RS17425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CN03_RS17450	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CN03_RS17475	COG0582	viral genome integration into host DNA
CN03_RS17535	COG3550	peptidyl-serine autophosphorylation
CN03_RS17540	COG1396	sequence-specific DNA binding
CN03_RS17550	COG3550	peptidyl-serine autophosphorylation
CN03_RS17565	COG4716	Myosin-crossreactive antigen
CN03_RS17575	COG0583	DNA-binding transcription factor activity
CN03_RS17585	COG1979	alcohol dehydrogenase
CN03_RS17590	COG2130	NADP-dependent
CN03_RS17600	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CN03_RS17620	COG4372	Transposase
CN03_RS17650	COG1404	Belongs to the peptidase S8 family
CN03_RS17680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CN03_RS17685	COG0746	molybdenum cofactor guanylyltransferase activity
CN03_RS17690	COG0521	Mo-molybdopterin cofactor biosynthetic process
CN03_RS17695	COG0315	cyclic pyranopterin monophosphate synthase activity
CN03_RS17700	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CN03_RS17705	COG0314	molybdopterin synthase activity
CN03_RS17720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CN03_RS17735	COG1872	DUF167
CN03_RS17740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CN03_RS17745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CN03_RS17745	COG2813	Specifically methylates the guanine in position
CN03_RS17755	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CN03_RS17765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CN03_RS17770	COG4667	esterase of the alpha-beta hydrolase superfamily
CN03_RS17780	COG0527	aspartate kinase activity
CN03_RS17785	COG1917	Cupin 2, conserved barrel domain protein
CN03_RS17800	COG1846	Transcriptional regulator
CN03_RS17830	COG0534	Mate efflux family protein
CN03_RS17850	COG2840	Smr protein MutS2
CN03_RS17855	COG0204	Acyl-transferase
CN03_RS17860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CN03_RS17865	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CN03_RS17890	COG3118	belongs to the thioredoxin family
CN03_RS17900	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CN03_RS17905	COG0210	DNA helicase
CN03_RS17910	COG1737	Transcriptional regulator
CN03_RS17915	COG0004	ammonium transporteR
CN03_RS17920	COG0347	Belongs to the P(II) protein family
CN03_RS17940	COG0411	ABC transporter
CN03_RS17960	COG1802	Transcriptional regulator
CN03_RS17980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CN03_RS17985	COG3025	triphosphatase activity