locus-tag	class	description
TOL_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TOL_RS00010	COG0592	DNA-directed DNA polymerase activity
TOL_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TOL_RS00050	COG1073	alpha beta
TOL_RS00055	COG2963	transposase activity
TOL_RS00060	COG2801	Transposase and inactivated derivatives
TOL_RS00075	COG0668	transmembrane transport
TOL_RS00090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TOL_RS00095	COG0751	glycine-tRNA ligase activity
TOL_RS00105	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TOL_RS00145	COG3150	esterase
TOL_RS00150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TOL_RS00155	COG3151	Protein conserved in bacteria
TOL_RS00160	COG0494	nUDIX hydrolase
TOL_RS00165	COG1538	Outer membrane efflux protein
TOL_RS00170	COG1519	Transferase
TOL_RS00180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TOL_RS00185	COG1560	Kdo2-lipid A biosynthetic process
TOL_RS00190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TOL_RS00195	COG0348	domain, Protein
TOL_RS00200	COG0515	serine threonine protein kinase
TOL_RS00205	COG2116	formate transmembrane transporter activity
TOL_RS00210	COG1960	acyl-CoA dehydrogenase activity
TOL_RS00215	COG1028	Short-chain dehydrogenase reductase Sdr
TOL_RS00230	COG1028	Short-chain dehydrogenase reductase Sdr
TOL_RS00240	COG1404	Belongs to the peptidase S8 family
TOL_RS00315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TOL_RS00320	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TOL_RS00350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TOL_RS00355	COG1349	DNA-binding transcription factor activity
TOL_RS00380	COG3245	cytochrome
TOL_RS00385	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TOL_RS00415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TOL_RS00450	COG4774	siderophore transport
TOL_RS00455	COG0501	Belongs to the peptidase M48B family
TOL_RS00460	COG5002	protein histidine kinase activity
TOL_RS00460	COG0784	Response regulator, receiver
TOL_RS00460	COG2205	protein histidine kinase activity
TOL_RS00495	COG0339	signal peptide processing
TOL_RS00500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TOL_RS00520	COG2010	Cytochrome c
TOL_RS00535	COG3148	PFAM DTW domain containing protein
TOL_RS00545	COG0217	transcriptional regulatory protein
TOL_RS00560	COG0408	coproporphyrinogen oxidase activity
TOL_RS00565	COG0009	L-threonylcarbamoyladenylate synthase
TOL_RS00570	COG0758	DNA mediated transformation
TOL_RS00580	COG0242	peptide deformylase activity
TOL_RS00585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TOL_RS00595	COG0569	domain protein
TOL_RS00600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TOL_RS00605	COG0659	secondary active sulfate transmembrane transporter activity
TOL_RS00610	COG0589	response to stress
TOL_RS00615	COG1595	DNA-templated transcription, initiation
TOL_RS00640	COG0745	RESPONSE REGULATOR receiver
TOL_RS00650	COG0742	ribosomal rna small subunit methyltransferase
TOL_RS00660	COG0552	protein localization to endoplasmic reticulum
TOL_RS00665	COG2884	Cell division ATP-binding protein ftsE
TOL_RS00670	COG2177	Part of the ABC transporter FtsEX involved in
TOL_RS00680	COG1607	acyl-coa hydrolase
TOL_RS00700	COG0573	inorganic phosphate transmembrane transporter activity
TOL_RS00710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TOL_RS00750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOL_RS00775	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TOL_RS00805	COG1301	dicarboxylic acid transport
TOL_RS00820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TOL_RS00825	COG0583	DNA-binding transcription factor activity
TOL_RS00845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TOL_RS00850	COG1758	RNA polymerase activity
TOL_RS00855	COG0194	GDP metabolic process
TOL_RS00860	COG3384	dioxygenase
TOL_RS00930	COG0515	serine threonine protein kinase
TOL_RS00930	COG2815	serine threonine protein kinase
TOL_RS00975	COG1561	YicC-like family, N-terminal region
TOL_RS00980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TOL_RS00990	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TOL_RS01000	COG1309	transcriptional regulator
TOL_RS01005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TOL_RS01015	COG0756	dUTP diphosphatase activity
TOL_RS01020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TOL_RS01025	COG2003	Belongs to the UPF0758 family
TOL_RS01030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TOL_RS01035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TOL_RS01050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TOL_RS01055	COG0405	Gamma-glutamyltransferase
TOL_RS01060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TOL_RS01070	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TOL_RS01110	COG3273	potassium ion transport
TOL_RS01110	COG0471	metal ion transport
TOL_RS01125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOL_RS01130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOL_RS01135	COG0537	adenosine 5'-monophosphoramidase activity
TOL_RS01140	COG0140	phosphoribosyl-ATP diphosphatase activity
TOL_RS01145	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TOL_RS01150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TOL_RS01160	COG2226	methyltransferase
TOL_RS01185	COG4771	TonB-dependent receptor
TOL_RS01190	COG2885	chlorophyll binding
TOL_RS01205	COG4181	ATPase activity
TOL_RS01210	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TOL_RS01215	COG0501	Belongs to the peptidase M48B family
TOL_RS01220	COG1704	LemA family
TOL_RS01235	COG0513	Belongs to the DEAD box helicase family
TOL_RS01280	COG0540	Belongs to the ATCase OTCase family
TOL_RS01285	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TOL_RS01295	COG1678	Uncharacterized ACR, COG1678
TOL_RS01335	COG2198	Histidine kinase
TOL_RS01335	COG0784	Response regulator, receiver
TOL_RS01335	COG0643	Histidine kinase
TOL_RS01340	COG2201	protein-glutamate methylesterase activity
TOL_RS01365	COG2194	sulfuric ester hydrolase activity
TOL_RS01395	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TOL_RS01400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TOL_RS01405	COG0640	Transcriptional regulator
TOL_RS01410	COG0714	Associated with various cellular activities
TOL_RS01420	COG1305	Transglutaminase-like
TOL_RS01430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TOL_RS01450	COG1177	transmembrane transport
TOL_RS01455	COG1176	ABC-type spermidine putrescine transport system, permease component I
TOL_RS01460	COG3842	ATPase activity
TOL_RS01465	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TOL_RS01475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TOL_RS01495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TOL_RS01500	COG1981	membrane
TOL_RS01510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TOL_RS01525	COG0316	Belongs to the HesB IscA family
TOL_RS01540	COG0739	heme binding
TOL_RS01595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOL_RS01605	COG0456	acetyltransferase
TOL_RS01615	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TOL_RS01630	COG0018	arginyl-trna synthetase
TOL_RS01635	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TOL_RS01640	COG0514	ATP-dependent DNA helicase (RecQ)
TOL_RS01665	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TOL_RS01690	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TOL_RS01715	COG0131	Imidazoleglycerol-phosphate dehydratase
TOL_RS01720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TOL_RS01725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TOL_RS01730	COG0107	imidazoleglycerol-phosphate synthase activity
TOL_RS01745	COG0129	dihydroxy-acid dehydratase activity
TOL_RS01895	COG0631	protein serine/threonine phosphatase activity
TOL_RS01925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TOL_RS01935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TOL_RS01940	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TOL_RS01945	COG0723	plastoquinol--plastocyanin reductase activity
TOL_RS01950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TOL_RS01955	COG2857	Cytochrome c1
TOL_RS01960	COG0625	glutathione transferase activity
TOL_RS01965	COG2969	positive regulation of protein catabolic process
TOL_RS01970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TOL_RS02055	COG4372	Transposase
TOL_RS02090	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TOL_RS02130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TOL_RS02135	COG2137	regulation of response to DNA damage stimulus
TOL_RS02145	COG1252	NADH dehydrogenase
TOL_RS02150	COG2267	carboxylic ester hydrolase activity
TOL_RS02170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TOL_RS02175	COG0527	aspartate kinase activity
TOL_RS02180	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TOL_RS02280	COG4382	Mu-like prophage protein Gp16
TOL_RS02330	COG0640	Transcriptional regulator
TOL_RS02340	COG4373	Mu-like prophage FluMu protein gp28
TOL_RS02345	COG4383	Mu-like prophage protein gp29
TOL_RS02355	COG2369	cell adhesion
TOL_RS02390	COG4397	Mu-like prophage major head subunit gpT
TOL_RS02420	COG4386	tail sheath protein
TOL_RS02500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TOL_RS02530	COG1671	Belongs to the UPF0178 family
TOL_RS02555	COG1024	Enoyl-CoA hydratase
TOL_RS02575	COG2203	Gaf domain
TOL_RS02575	COG5001	Diguanylate cyclase
TOL_RS02575	COG3706	GGDEF domain
TOL_RS02575	COG4251	negative regulation of phosphorylation
TOL_RS02600	COG4372	Transposase
TOL_RS02635	COG0672	)-iron permease
TOL_RS02640	COG0789	Transcriptional regulator
TOL_RS02645	COG1230	cation diffusion facilitator family transporter
TOL_RS02675	COG1230	cation diffusion facilitator family transporter
TOL_RS02680	COG1742	UPF0060 membrane protein
TOL_RS02695	COG5002	protein histidine kinase activity
TOL_RS02700	COG0745	RESPONSE REGULATOR receiver
TOL_RS02710	COG2132	Multicopper oxidase
TOL_RS02735	COG2217	Heavy metal translocating P-type atpase
TOL_RS02780	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOL_RS02815	COG0358	DNA primase activity
TOL_RS02820	COG1610	YqeY-like protein
TOL_RS02825	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TOL_RS02830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TOL_RS02835	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TOL_RS02840	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TOL_RS02840	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TOL_RS02870	COG2719	SpoVR family
TOL_RS02875	COG2718	Belongs to the UPF0229 family
TOL_RS02880	COG2766	serine protein kinase
TOL_RS02885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TOL_RS02890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TOL_RS02900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TOL_RS02905	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TOL_RS02910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOL_RS02915	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TOL_RS02920	COG3178	'Phosphotransferase
TOL_RS02925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TOL_RS02930	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TOL_RS02940	COG1272	protein, Hemolysin III
TOL_RS02945	COG2827	Endonuclease containing a URI domain
TOL_RS02965	COG0424	maF-like protein
TOL_RS02970	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TOL_RS03005	COG2154	pterin-4-alpha-carbinolamine dehydratase
TOL_RS03025	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TOL_RS03040	COG2010	Cytochrome c
TOL_RS03045	COG1785	Belongs to the alkaline phosphatase family
TOL_RS03050	COG1611	Belongs to the LOG family
TOL_RS03065	COG0788	formyltetrahydrofolate deformylase activity
TOL_RS03070	COG0183	Belongs to the thiolase family
TOL_RS03075	COG2267	carboxylic ester hydrolase activity
TOL_RS03095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TOL_RS03100	COG1040	competence protein
TOL_RS03105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TOL_RS03120	COG1960	acyl-CoA dehydrogenase activity
TOL_RS03125	COG1960	acyl-CoA dehydrogenase activity
TOL_RS03130	COG1309	transcriptional regulator
TOL_RS03160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOL_RS03165	COG0134	indole-3-glycerol-phosphate synthase activity
TOL_RS03175	COG1765	OsmC-like protein
TOL_RS03180	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TOL_RS03185	COG2814	Major facilitator Superfamily
TOL_RS03190	COG2813	Specifically methylates the guanine in position
TOL_RS03195	COG0789	Transcriptional regulator
TOL_RS03200	COG1366	Belongs to the anti-sigma-factor antagonist family
TOL_RS03235	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TOL_RS03240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOL_RS03265	COG0678	peroxiredoxin activity
TOL_RS03265	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TOL_RS03275	COG1881	PFAM PEBP family protein
TOL_RS03280	COG4251	negative regulation of phosphorylation
TOL_RS03280	COG5001	Diguanylate cyclase
TOL_RS03280	COG2203	Gaf domain
TOL_RS03280	COG3706	GGDEF domain
TOL_RS03310	COG1730	sister chromatid segregation
TOL_RS03325	COG2197	response regulator
TOL_RS03335	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TOL_RS03340	COG0237	dephospho-CoA kinase activity
TOL_RS03345	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TOL_RS03370	COG1115	amino acid carrier protein
TOL_RS03375	COG3023	N-Acetylmuramoyl-L-alanine amidase
TOL_RS03385	COG1940	carbohydrate kinase activity
TOL_RS03400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TOL_RS03410	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TOL_RS03415	COG1492	cobalamin metabolic process
TOL_RS03425	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TOL_RS03435	COG0508	dehydrogenase complex catalyzes the overall conversion of
TOL_RS03440	COG0840	transmembrane signaling receptor activity
TOL_RS03455	COG1028	Short-chain dehydrogenase reductase Sdr
TOL_RS03460	COG0789	Transcriptional regulator
TOL_RS03465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TOL_RS03470	COG1960	acyl-CoA dehydrogenase activity
TOL_RS03475	COG0183	Belongs to the thiolase family
TOL_RS03480	COG1024	Enoyl-CoA hydratase
TOL_RS03480	COG1250	3-hydroxyacyl-CoA dehydrogenase
TOL_RS03485	COG2268	Band 7 protein
TOL_RS03505	COG2072	flavoprotein involved in K transport
TOL_RS03555	COG4628	conserved protein (DUF2132)
TOL_RS03565	COG0025	NhaP-type Na H and K H
TOL_RS03575	COG0513	Belongs to the DEAD box helicase family
TOL_RS03585	COG0084	hydrolase, TatD family'
TOL_RS03605	COG0189	ligase activity
TOL_RS03635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TOL_RS03650	COG0840	transmembrane signaling receptor activity
TOL_RS03655	COG0488	(ABC) transporter
TOL_RS03660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TOL_RS03665	COG4628	conserved protein (DUF2132)
TOL_RS03680	COG2996	Protein conserved in bacteria
TOL_RS03685	COG0579	oxidoreductase
TOL_RS03690	COG0366	Alpha amylase catalytic
TOL_RS03705	COG0840	transmembrane signaling receptor activity
TOL_RS03735	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TOL_RS03735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TOL_RS03740	COG0509	glycine decarboxylation via glycine cleavage system
TOL_RS03745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TOL_RS03765	COG0450	alkyl hydroperoxide reductase
TOL_RS03780	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TOL_RS03790	COG0156	8-amino-7-oxononanoate synthase activity
TOL_RS03850	COG0275	rRNA processing
TOL_RS03865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TOL_RS03870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TOL_RS03875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TOL_RS03885	COG0772	Belongs to the SEDS family
TOL_RS03890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TOL_RS03895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOL_RS03900	COG1181	Belongs to the D-alanine--D-alanine ligase family
TOL_RS03905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TOL_RS03920	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TOL_RS03925	COG0739	heme binding
TOL_RS03930	COG0653	protein targeting
TOL_RS03955	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TOL_RS03960	COG4535	Mg2 and Co2 transporter CorC
TOL_RS03970	COG1702	phosphate starvation-inducible protein PhoH
TOL_RS03975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOL_RS04000	COG2814	Major facilitator Superfamily
TOL_RS04010	COG0193	aminoacyl-tRNA hydrolase activity
TOL_RS04015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TOL_RS04020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TOL_RS04030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TOL_RS04045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TOL_RS04050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TOL_RS04055	COG2890	protein-(glutamine-N5) methyltransferase activity
TOL_RS04065	COG0446	pyridine nucleotide-disulphide oxidoreductase
TOL_RS04070	COG0598	Magnesium transport protein CorA
TOL_RS04080	COG0792	nuclease activity
TOL_RS04130	COG1846	Transcriptional regulator
TOL_RS04140	COG1597	lipid kinase activity
TOL_RS04155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TOL_RS04205	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TOL_RS04235	COG2308	Evidence 4 Homologs of previously reported genes of
TOL_RS04240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TOL_RS04245	COG1024	Enoyl-CoA hydratase
TOL_RS04265	COG1132	(ABC) transporter
TOL_RS04270	COG0019	diaminopimelate decarboxylase activity
TOL_RS04280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TOL_RS04280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TOL_RS04300	COG0500	methyltransferase
TOL_RS04310	COG2067	long-chain fatty acid transport protein
TOL_RS04325	COG0583	DNA-binding transcription factor activity
TOL_RS04345	COG0811	peptide transport
TOL_RS04350	COG0811	peptide transport
TOL_RS04355	COG0848	biopolymer transport protein
TOL_RS04360	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
TOL_RS04385	COG1024	Enoyl-CoA hydratase
TOL_RS04435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TOL_RS04440	COG0481	GTPase activity
TOL_RS04450	COG0571	ribonuclease III activity
TOL_RS04455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TOL_RS04460	COG1381	Involved in DNA repair and RecF pathway recombination
TOL_RS04470	COG0736	holo-[acyl-carrier-protein] synthase activity
TOL_RS04475	COG0784	Response regulator, receiver
TOL_RS04475	COG5002	protein histidine kinase activity
TOL_RS04475	COG2205	protein histidine kinase activity
TOL_RS04485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TOL_RS04490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TOL_RS04495	COG3956	TIGRFAM MazG family protein
TOL_RS04500	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TOL_RS04505	COG0563	adenylate kinase activity
TOL_RS04515	COG1214	PFAM Peptidase M22, glycoprotease
TOL_RS04520	COG1968	undecaprenyl-diphosphatase activity
TOL_RS04530	COG2937	Belongs to the GPAT DAPAT family
TOL_RS04535	COG2900	Belongs to the SlyX family
TOL_RS04570	COG0105	UTP biosynthetic process
TOL_RS04575	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TOL_RS04590	COG0124	histidyl-tRNA synthetase
TOL_RS04605	COG1160	GTP binding
TOL_RS04610	COG1024	Enoyl-CoA hydratase
TOL_RS04610	COG1250	3-hydroxyacyl-CoA dehydrogenase
TOL_RS04615	COG1960	acyl-CoA dehydrogenase activity
TOL_RS04650	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TOL_RS04655	COG0830	nickel cation binding
TOL_RS04660	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TOL_RS04665	COG0804	urea catabolic process
TOL_RS04670	COG0832	Belongs to the urease beta subunit family
TOL_RS04675	COG0831	urea catabolic process
TOL_RS04680	COG0829	nickel cation binding
TOL_RS04685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOL_RS04685	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOL_RS04690	COG4536	flavin adenine dinucleotide binding
TOL_RS04700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TOL_RS04710	COG0432	Pfam Uncharacterised protein family UPF0047
TOL_RS04720	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TOL_RS04740	COG4804	nuclease activity
TOL_RS04795	COG2193	ferroxidase activity
TOL_RS04800	COG4067	protein conserved in archaea
TOL_RS04800	COG0189	ligase activity
TOL_RS04815	COG1639	'signal transduction protein
TOL_RS04820	COG2084	Dehydrogenase
TOL_RS04825	COG3622	Belongs to the hyi family
TOL_RS04830	COG3313	Fe-S protein
TOL_RS04835	COG1278	Cold shock
TOL_RS04855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOL_RS04875	COG2264	protein methyltransferase activity
TOL_RS04890	COG0084	hydrolase, TatD family'
TOL_RS04910	COG2264	protein methyltransferase activity
TOL_RS04935	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
TOL_RS04950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TOL_RS04960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOL_RS04965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL_RS04995	COG0300	oxidoreductase activity
TOL_RS05010	COG1025	Belongs to the peptidase M16 family
TOL_RS05020	COG2207	Transcriptional regulator
TOL_RS05020	COG4753	response regulator
TOL_RS05030	COG0784	Response regulator, receiver
TOL_RS05030	COG5002	protein histidine kinase activity
TOL_RS05030	COG2205	protein histidine kinase activity
TOL_RS05060	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TOL_RS05085	COG2203	Gaf domain
TOL_RS05085	COG3706	GGDEF domain
TOL_RS05085	COG5001	Diguanylate cyclase
TOL_RS05085	COG4251	negative regulation of phosphorylation
TOL_RS05090	COG0204	Acyl-transferase
TOL_RS05100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TOL_RS05115	COG4251	negative regulation of phosphorylation
TOL_RS05115	COG3706	GGDEF domain
TOL_RS05115	COG2203	Gaf domain
TOL_RS05115	COG5001	Diguanylate cyclase
TOL_RS05155	COG0252	asparaginase activity
TOL_RS05180	COG4133	protoheme IX ABC transporter activity
TOL_RS05185	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TOL_RS05205	COG1138	Cytochrome C-type biogenesis protein
TOL_RS05210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TOL_RS05275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TOL_RS05285	COG0784	Response regulator, receiver
TOL_RS05285	COG2205	protein histidine kinase activity
TOL_RS05315	COG2202	Pas domain
TOL_RS05315	COG2200	EAL domain
TOL_RS05315	COG2199	diguanylate cyclase activity
TOL_RS05340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TOL_RS05355	COG2095	MarC family integral membrane protein
TOL_RS05370	COG1253	flavin adenine dinucleotide binding
TOL_RS05375	COG0596	Alpha beta hydrolase
TOL_RS05380	COG0681	Belongs to the peptidase S26 family
TOL_RS05405	COG0494	nUDIX hydrolase
TOL_RS05480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TOL_RS05485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TOL_RS05490	COG0705	Rhomboid family
TOL_RS05505	COG0308	aminopeptidase N
TOL_RS05520	COG2409	Drug exporters of the RND superfamily
TOL_RS05570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL_RS05575	COG0488	(ABC) transporter
TOL_RS05590	COG1250	3-hydroxyacyl-CoA dehydrogenase
TOL_RS05590	COG1024	Enoyl-CoA hydratase
TOL_RS05595	COG0183	Belongs to the thiolase family
TOL_RS05630	COG2801	Transposase and inactivated derivatives
TOL_RS05650	COG1902	pentaerythritol trinitrate reductase activity
TOL_RS05655	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TOL_RS05655	COG0493	'glutamate synthase
TOL_RS05660	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
TOL_RS05680	COG3239	Fatty acid desaturase
TOL_RS05690	COG1196	nuclear chromosome segregation
TOL_RS05695	COG3115	cell septum assembly
TOL_RS05700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TOL_RS05705	COG0431	NADPH-dependent FMN reductase
TOL_RS05710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TOL_RS05710	COG0519	Catalyzes the synthesis of GMP from XMP
TOL_RS05745	COG2304	oxidoreductase activity
TOL_RS05760	COG0714	Associated with various cellular activities
TOL_RS05785	COG3130	regulation of translation
TOL_RS05795	COG0004	ammonium transporteR
TOL_RS05800	COG0657	acetylesterase activity
TOL_RS05855	COG0307	riboflavin synthase, alpha
TOL_RS05880	COG3541	Predicted nucleotidyltransferase
TOL_RS05915	COG2161	toxin-antitoxin pair type II binding
TOL_RS05920	COG4115	mRNA cleavage
TOL_RS05930	COG2801	Transposase and inactivated derivatives
TOL_RS05935	COG0730	response to heat
TOL_RS05940	COG1643	Atp-dependent helicase
TOL_RS05960	COG3264	Mechanosensitive ion channel
TOL_RS05960	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
TOL_RS05970	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
TOL_RS05985	COG0517	IMP dehydrogenase activity
TOL_RS05985	COG0516	GMP reductase activity
TOL_RS05990	COG1028	Short-chain dehydrogenase reductase Sdr
TOL_RS06000	COG2223	nitrite transmembrane transporter activity
TOL_RS06020	COG2267	carboxylic ester hydrolase activity
TOL_RS06025	COG2925	Exonuclease
TOL_RS06035	COG2818	Glycosylase
TOL_RS06055	COG1741	Belongs to the pirin family
TOL_RS06065	COG0513	Belongs to the DEAD box helicase family
TOL_RS06070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TOL_RS06075	COG1946	Acyl-CoA thioesterase
TOL_RS06090	COG0739	heme binding
TOL_RS06095	COG1570	exodeoxyribonuclease VII activity
TOL_RS06120	COG0519	Catalyzes the synthesis of GMP from XMP
TOL_RS06120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TOL_RS06130	COG2885	chlorophyll binding
TOL_RS06145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TOL_RS06150	COG0795	lipopolysaccharide-transporting ATPase activity
TOL_RS06155	COG0795	lipopolysaccharide-transporting ATPase activity
TOL_RS06165	COG0259	pyridoxamine-phosphate oxidase activity
TOL_RS06170	COG3001	Fructosamine kinase
TOL_RS06210	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
TOL_RS06225	COG4372	Transposase
TOL_RS06255	COG0175	sulfate reduction
TOL_RS06260	COG2945	thiolester hydrolase activity
TOL_RS06265	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TOL_RS06295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TOL_RS06310	COG5001	Diguanylate cyclase
TOL_RS06310	COG3706	GGDEF domain
TOL_RS06310	COG2203	Gaf domain
TOL_RS06310	COG4251	negative regulation of phosphorylation
TOL_RS06335	COG0343	queuine tRNA-ribosyltransferase activity
TOL_RS06340	COG1862	Preprotein translocase
TOL_RS06355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TOL_RS06365	COG0583	DNA-binding transcription factor activity
TOL_RS06385	COG0525	valine-tRNA ligase activity
TOL_RS06390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TOL_RS06405	COG4807	Protein conserved in bacteria
TOL_RS06425	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
TOL_RS06445	COG2963	transposase activity
TOL_RS06450	COG2801	Transposase and inactivated derivatives
TOL_RS06475	COG0525	valine-tRNA ligase activity
TOL_RS06490	COG2226	methyltransferase
TOL_RS06495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TOL_RS06505	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TOL_RS06555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOL_RS06560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL_RS06615	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TOL_RS06635	COG0789	Transcriptional regulator
TOL_RS06650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TOL_RS06655	COG1187	pseudouridine synthase activity
TOL_RS06670	COG0154	amidase activity
TOL_RS06730	COG1054	Belongs to the UPF0176 family
TOL_RS06740	COG4660	Part of a membrane complex involved in electron transport
TOL_RS06745	COG4659	FMN binding
TOL_RS06750	COG4658	electron transport chain
TOL_RS06755	COG4656	Part of a membrane complex involved in electron transport
TOL_RS06760	COG2878	Part of a membrane complex involved in electron transport
TOL_RS06765	COG4657	Part of a membrane complex involved in electron transport
TOL_RS06780	COG0601	transmembrane transport
TOL_RS06785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TOL_RS06790	COG4172	Belongs to the ABC transporter superfamily
TOL_RS06800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TOL_RS06805	COG0489	protein tyrosine kinase activity
TOL_RS06810	COG1902	pentaerythritol trinitrate reductase activity
TOL_RS06810	COG0446	pyridine nucleotide-disulphide oxidoreductase
TOL_RS06815	COG2205	protein histidine kinase activity
TOL_RS06875	COG0579	oxidoreductase
TOL_RS06915	COG0442	prolyl-tRNA aminoacylation
TOL_RS06925	COG2818	Glycosylase
TOL_RS06965	COG1648	precorrin-2 dehydrogenase activity
TOL_RS06965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TOL_RS06970	COG0243	molybdopterin cofactor binding
TOL_RS06975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOL_RS06985	COG2223	nitrite transmembrane transporter activity
TOL_RS06990	COG2815	serine threonine protein kinase
TOL_RS06990	COG0515	serine threonine protein kinase
TOL_RS07000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOL_RS07010	COG1116	anion transmembrane transporter activity
TOL_RS07020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TOL_RS07025	COG1116	anion transmembrane transporter activity
TOL_RS07025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TOL_RS07030	COG3707	response regulator
TOL_RS07060	COG4773	Receptor
TOL_RS07070	COG0686	Belongs to the AlaDH PNT family
TOL_RS07095	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TOL_RS07100	COG1074	ATP-dependent DNA helicase activity
TOL_RS07105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TOL_RS07115	COG0439	Biotin carboxylase
TOL_RS07135	COG0463	Glycosyl transferase, family 2
TOL_RS07145	COG0859	PFAM glycosyl transferase family 9
TOL_RS07155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TOL_RS07160	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TOL_RS07165	COG0784	Response regulator, receiver
TOL_RS07165	COG0835	chemotaxis
TOL_RS07175	COG2084	Dehydrogenase
TOL_RS07190	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
TOL_RS07195	COG1053	succinate dehydrogenase
TOL_RS07215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TOL_RS07220	COG0045	succinate-CoA ligase (ADP-forming) activity
TOL_RS07305	COG0589	response to stress
TOL_RS07310	COG1741	Belongs to the pirin family
TOL_RS07320	COG0431	NADPH-dependent FMN reductase
TOL_RS07325	COG1012	belongs to the aldehyde dehydrogenase family
TOL_RS07330	COG0006	proline dipeptidase activity
TOL_RS07335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TOL_RS07340	COG1473	amidohydrolase
TOL_RS07345	COG0280	phosphate acetyltransferase
TOL_RS07350	COG0589	response to stress
TOL_RS07360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TOL_RS07370	COG0473	3-isopropylmalate dehydrogenase activity
TOL_RS07400	COG0135	phosphoribosylanthranilate isomerase activity
TOL_RS07405	COG0133	tryptophan synthase activity
TOL_RS07410	COG0159	tryptophan synthase activity
TOL_RS07415	COG0285	dihydrofolate synthase activity
TOL_RS07425	COG1286	toxin biosynthetic process
TOL_RS07440	COG0714	Associated with various cellular activities
TOL_RS07460	COG0840	transmembrane signaling receptor activity
TOL_RS07465	COG0667	Aldo Keto reductase
TOL_RS07525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TOL_RS07535	COG0534	Mate efflux family protein
TOL_RS07540	COG3101	peptidyl-lysine hydroxylation
TOL_RS07570	COG5265	(ABC) transporter
TOL_RS07575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TOL_RS07580	COG0824	Thioesterase
TOL_RS07610	COG0784	Response regulator, receiver
TOL_RS07610	COG2198	Histidine kinase
TOL_RS07610	COG2205	protein histidine kinase activity
TOL_RS07615	COG1067	ATP-dependent peptidase activity
TOL_RS07625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TOL_RS07630	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TOL_RS07635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TOL_RS07645	COG3100	YcgL domain-containing protein
TOL_RS07650	COG2983	Belongs to the UPF0260 family
TOL_RS07740	COG2030	dehydratase
TOL_RS07745	COG0318	PFAM AMP-dependent synthetase and ligase
TOL_RS07750	COG1643	Atp-dependent helicase
TOL_RS07760	COG3220	belongs to the UPF0276 family
TOL_RS07770	COG2853	Lipoprotein
TOL_RS07780	COG0730	response to heat
TOL_RS07795	COG0560	Phosphoserine phosphatase
TOL_RS07800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TOL_RS07835	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TOL_RS07870	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TOL_RS07875	COG0372	Belongs to the citrate synthase family
TOL_RS07895	COG1530	ribonuclease E activity
TOL_RS07905	COG0546	phosphoglycolate phosphatase activity
TOL_RS07910	COG0616	signal peptide processing
TOL_RS07920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TOL_RS07925	COG0416	fatty acid biosynthetic process
TOL_RS07935	COG1028	Short-chain dehydrogenase reductase Sdr
TOL_RS07940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TOL_RS07945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TOL_RS07950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TOL_RS07955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TOL_RS07980	COG0666	response to abiotic stimulus
TOL_RS08000	COG1104	cysteine desulfurase activity
TOL_RS08015	COG0811	peptide transport
TOL_RS08020	COG0811	peptide transport
TOL_RS08025	COG0848	biopolymer transport protein
TOL_RS08045	COG0708	Exodeoxyribonuclease III
TOL_RS08070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TOL_RS08070	COG0301	tRNA thio-modification
TOL_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
TOL_RS08095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TOL_RS08195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL_RS08200	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOL_RS08225	COG5002	protein histidine kinase activity
TOL_RS08235	COG2132	Multicopper oxidase
TOL_RS08285	COG2217	Heavy metal translocating P-type atpase
TOL_RS08320	COG0058	SHG alpha-glucan phosphorylase activity
TOL_RS08325	COG0723	plastoquinol--plastocyanin reductase activity
TOL_RS08380	COG0798	PFAM Bile acid sodium symporter
TOL_RS08385	COG0431	NADPH-dependent FMN reductase
TOL_RS08395	COG0640	Transcriptional regulator
TOL_RS08435	COG2326	polyphosphate kinase activity
TOL_RS08445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOL_RS08465	COG3156	type II secretion system protein K
TOL_RS08550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TOL_RS08555	COG0322	excinuclease ABC activity
TOL_RS08560	COG2197	response regulator
TOL_RS08565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TOL_RS08565	COG1042	CoA-binding domain protein
TOL_RS08565	COG0045	succinate-CoA ligase (ADP-forming) activity
TOL_RS08570	COG0123	including yeast histone deacetylase and acetoin utilization protein
TOL_RS08580	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
TOL_RS08585	COG2923	Belongs to the DsrF TusC family
TOL_RS08595	COG2920	part of a sulfur-relay system
TOL_RS08600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOL_RS08610	COG1648	precorrin-2 dehydrogenase activity
TOL_RS08610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TOL_RS08615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TOL_RS08620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TOL_RS08625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TOL_RS08630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TOL_RS08635	COG1674	ftsk spoiiie
TOL_RS08640	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TOL_RS08645	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TOL_RS08650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TOL_RS08655	COG0542	response to heat
TOL_RS08660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TOL_RS08665	COG1278	Cold shock
TOL_RS08675	COG1187	pseudouridine synthase activity
TOL_RS08690	COG2915	High frequency lysogenization protein hflD homolog
TOL_RS08700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TOL_RS08705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TOL_RS08720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TOL_RS08730	COG1477	protein flavinylation
TOL_RS08765	COG0826	peptidase U32
TOL_RS08770	COG0564	pseudouridine synthase activity
TOL_RS08790	COG2062	phosphohistidine phosphatase, SixA
TOL_RS08800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TOL_RS08810	COG0745	RESPONSE REGULATOR receiver
TOL_RS08820	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TOL_RS08820	COG0316	Belongs to the HesB IscA family
TOL_RS08830	COG0534	Mate efflux family protein
TOL_RS08835	COG0584	glycerophosphoryl diester phosphodiesterase
TOL_RS08840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOL_RS08850	COG4651	solute:proton antiporter activity
TOL_RS08850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TOL_RS08855	COG0604	alcohol dehydrogenase
TOL_RS08860	COG0616	signal peptide processing
TOL_RS08880	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TOL_RS08885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TOL_RS08890	COG0328	RNA-DNA hybrid ribonuclease activity
TOL_RS08900	COG0741	lytic transglycosylase activity
TOL_RS08900	COG1388	LysM domain
TOL_RS08915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOL_RS08930	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOL_RS08935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TOL_RS08940	COG0740	serine-type endopeptidase activity
TOL_RS08945	COG0544	peptidyl-prolyl cis-trans isomerase activity
TOL_RS08965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TOL_RS08970	COG2133	pyrroloquinoline quinone binding
TOL_RS08980	COG3177	Filamentation induced by cAMP protein fic
TOL_RS08990	COG2860	membrane
TOL_RS09020	COG0215	cysteine-tRNA ligase activity
TOL_RS09025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOL_RS09030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TOL_RS09035	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOL_RS09045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TOL_RS09050	COG2835	tetraacyldisaccharide 4'-kinase activity
TOL_RS09055	COG1663	tetraacyldisaccharide 4'-kinase activity
TOL_RS09060	COG1132	(ABC) transporter
TOL_RS09065	COG0848	biopolymer transport protein
TOL_RS09070	COG0811	peptide transport
TOL_RS09090	COG4591	ABC-type transport system involved in lipoprotein release permease component
TOL_RS09105	COG1199	ATP-dependent helicase activity
TOL_RS09130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TOL_RS09160	COG2850	peptidyl-arginine hydroxylation
TOL_RS09175	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TOL_RS09185	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TOL_RS09200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOL_RS09205	COG0840	transmembrane signaling receptor activity
TOL_RS09225	COG3850	Histidine kinase
TOL_RS09225	COG4999	Histidine kinase
TOL_RS09225	COG3437	response regulator, receiver
TOL_RS09225	COG2205	protein histidine kinase activity
TOL_RS09270	COG2963	transposase activity
TOL_RS09275	COG2801	Transposase and inactivated derivatives
TOL_RS09320	COG2801	Transposase and inactivated derivatives
TOL_RS09325	COG2963	transposase activity
TOL_RS09350	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TOL_RS09350	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TOL_RS09355	COG0842	Transport permease protein
TOL_RS09360	COG1131	(ABC) transporter
TOL_RS09395	COG1846	Transcriptional regulator
TOL_RS09400	COG0386	Belongs to the glutathione peroxidase family
TOL_RS09405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TOL_RS09410	COG0436	Aminotransferase
TOL_RS09420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TOL_RS09425	COG3383	formate dehydrogenase (NAD+) activity
TOL_RS09435	COG1049	propionate catabolic process, 2-methylcitrate cycle
TOL_RS09450	COG3177	Filamentation induced by cAMP protein fic
TOL_RS09455	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TOL_RS09500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TOL_RS09515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOL_RS09540	COG0189	ligase activity
TOL_RS09565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOL_RS09630	COG3278	Belongs to the heme-copper respiratory oxidase family
TOL_RS09645	COG2010	Cytochrome c
TOL_RS09675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TOL_RS09685	COG0037	tRNA processing
TOL_RS09695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TOL_RS09705	COG0484	heat shock protein binding
TOL_RS09735	COG0271	Belongs to the BolA IbaG family
TOL_RS09765	COG0640	Transcriptional regulator
TOL_RS09785	COG3706	GGDEF domain
TOL_RS09790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TOL_RS09795	COG0302	gtp cyclohydrolase
TOL_RS09800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TOL_RS09810	COG3047	cAMP biosynthetic process
TOL_RS09820	COG1960	acyl-CoA dehydrogenase activity
TOL_RS09835	COG3239	Fatty acid desaturase
TOL_RS09865	COG0513	Belongs to the DEAD box helicase family
TOL_RS09870	COG3012	SEC-C Motif Domain Protein
TOL_RS09895	COG0798	PFAM Bile acid sodium symporter
TOL_RS09905	COG0640	Transcriptional regulator
TOL_RS09910	COG3268	Saccharopine dehydrogenase
TOL_RS09970	COG3179	chitinase
TOL_RS09980	COG2871	sodium ion transport
TOL_RS10000	COG1805	sodium ion transport
TOL_RS10005	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TOL_RS10015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TOL_RS10040	COG1472	Belongs to the glycosyl hydrolase 3 family
TOL_RS10045	COG1376	ErfK ybiS ycfS ynhG family protein
TOL_RS10055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TOL_RS10080	COG0326	Molecular chaperone. Has ATPase activity
TOL_RS10085	COG0352	thiamine-phosphate diphosphorylase activity
TOL_RS10090	COG2022	thiamine diphosphate biosynthetic process
TOL_RS10105	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TOL_RS10125	COG3437	response regulator, receiver
TOL_RS10145	COG5002	protein histidine kinase activity
TOL_RS10145	COG0784	Response regulator, receiver
TOL_RS10145	COG2205	protein histidine kinase activity
TOL_RS10150	COG0077	Prephenate dehydratase
TOL_RS10150	COG1605	Chorismate mutase
TOL_RS10155	COG0572	uridine kinase
TOL_RS10160	COG3769	mannosylglycerate metabolic process
TOL_RS10165	COG1215	transferase activity, transferring glycosyl groups
TOL_RS10185	COG0800	Aldolase
TOL_RS10195	COG0363	glucosamine-6-phosphate deaminase activity
TOL_RS10220	COG0545	Peptidyl-prolyl cis-trans isomerase
TOL_RS10235	COG4269	membrane
TOL_RS10250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TOL_RS10265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TOL_RS10280	COG4783	chaperone-mediated protein folding
TOL_RS10285	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TOL_RS10300	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
TOL_RS10305	COG2885	chlorophyll binding
TOL_RS10310	COG0823	Involved in the tonB-independent uptake of proteins
TOL_RS10330	COG0824	Thioesterase
TOL_RS10335	COG2255	four-way junction helicase activity
TOL_RS10340	COG0632	four-way junction helicase activity
TOL_RS10345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TOL_RS10355	COG0542	response to heat
TOL_RS10365	COG0583	DNA-binding transcription factor activity
TOL_RS10385	COG3022	response to hydroperoxide
TOL_RS10390	COG1960	acyl-CoA dehydrogenase activity
TOL_RS10395	COG1960	acyl-CoA dehydrogenase activity
TOL_RS10400	COG0318	PFAM AMP-dependent synthetase and ligase
TOL_RS10410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TOL_RS10415	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TOL_RS10420	COG3122	Protein conserved in bacteria
TOL_RS10425	COG0500	methyltransferase
TOL_RS10440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOL_RS10445	COG0577	efflux transmembrane transporter activity
TOL_RS10445	COG1136	(ABC) transporter
TOL_RS10450	COG1136	(ABC) transporter
TOL_RS10450	COG0577	efflux transmembrane transporter activity
TOL_RS10455	COG0577	efflux transmembrane transporter activity
TOL_RS10455	COG1136	(ABC) transporter
TOL_RS10485	COG1397	ADP-ribosylglycohydrolase
TOL_RS10495	COG2963	transposase activity
TOL_RS10500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOL_RS10530	COG0776	regulation of translation
TOL_RS10535	COG0072	phenylalanine-tRNA ligase activity
TOL_RS10540	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TOL_RS10545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TOL_RS10550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TOL_RS10555	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TOL_RS10560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TOL_RS10630	COG1045	serine acetyltransferase
TOL_RS10650	COG1215	transferase activity, transferring glycosyl groups
TOL_RS10655	COG0318	PFAM AMP-dependent synthetase and ligase
TOL_RS10670	COG1045	serine acetyltransferase
TOL_RS10700	COG3639	organic phosphonate transmembrane transporter activity
TOL_RS10710	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TOL_RS10715	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
TOL_RS10765	COG1518	maintenance of DNA repeat elements
TOL_RS10830	COG2197	response regulator
TOL_RS10835	COG4585	Histidine kinase
TOL_RS10840	COG0737	Belongs to the 5'-nucleotidase family
TOL_RS10860	COG5001	Diguanylate cyclase
TOL_RS10860	COG3706	GGDEF domain
TOL_RS10860	COG2203	Gaf domain
TOL_RS10860	COG4251	negative regulation of phosphorylation
TOL_RS10875	COG0556	nucleotide-excision repair
TOL_RS10880	COG0436	Aminotransferase
TOL_RS10900	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TOL_RS10910	COG0717	Belongs to the dCTP deaminase family
TOL_RS10915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TOL_RS10945	COG4372	Transposase
TOL_RS10960	COG0438	transferase activity, transferring glycosyl groups
TOL_RS11000	COG0284	orotidine-5'-phosphate decarboxylase activity
TOL_RS11005	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TOL_RS11010	COG0776	regulation of translation
TOL_RS11020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TOL_RS11025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TOL_RS11040	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TOL_RS11055	COG0402	S-adenosylhomocysteine deaminase activity
TOL_RS11060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TOL_RS11070	COG1028	Short-chain dehydrogenase reductase Sdr
TOL_RS11075	COG3706	GGDEF domain
TOL_RS11095	COG0180	Tryptophanyl-tRNA synthetase
TOL_RS11100	COG0180	Tryptophanyl-tRNA synthetase
TOL_RS11105	COG0009	L-threonylcarbamoyladenylate synthase
TOL_RS11110	COG0613	PHP domain protein
TOL_RS11115	COG2917	probably involved in intracellular septation
TOL_RS11120	COG2350	Protein conserved in bacteria
TOL_RS11135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TOL_RS11145	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TOL_RS11145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TOL_RS11160	COG3243	poly(R)-hydroxyalkanoic acid synthase
TOL_RS11180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TOL_RS11220	COG1295	ribonuclease BN
TOL_RS11225	COG1393	Belongs to the ArsC family
TOL_RS11270	COG0443	Heat shock 70 kDa protein
TOL_RS11275	COG1285	pathogenesis
TOL_RS11315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TOL_RS11330	COG0719	Fe-S assembly protein
TOL_RS11335	COG0396	ATPase activity
TOL_RS11340	COG0719	Fe-S assembly protein
TOL_RS11345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TOL_RS11365	COG0400	carboxylic ester hydrolase activity
TOL_RS11380	COG1393	Belongs to the ArsC family
TOL_RS11385	COG2171	N-acyltransferase activity
TOL_RS11400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TOL_RS11405	COG0346	lactoylglutathione lyase activity
TOL_RS11430	COG0697	spore germination
TOL_RS11435	COG1846	Transcriptional regulator
TOL_RS11445	COG0583	DNA-binding transcription factor activity
TOL_RS11450	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TOL_RS11450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TOL_RS11460	COG1451	nucleotide metabolic process
TOL_RS11490	COG0564	pseudouridine synthase activity
TOL_RS11545	COG0137	argininosuccinate synthase activity
TOL_RS11555	COG0418	dihydroorotase activity
TOL_RS11560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TOL_RS11565	COG3112	Uncharacterised protein family (UPF0231)
TOL_RS11575	COG3152	Membrane
TOL_RS11580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TOL_RS11585	COG0676	glucose-6-phosphate 1-epimerase activity
TOL_RS11590	COG1187	pseudouridine synthase activity
TOL_RS11610	COG0436	Aminotransferase
TOL_RS11630	COG0864	Transcriptional regulator
TOL_RS11650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TOL_RS11655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TOL_RS11670	COG0439	Biotin carboxylase
TOL_RS11675	COG1024	Enoyl-CoA hydratase
TOL_RS11680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TOL_RS11695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TOL_RS11695	COG1017	nitric oxide dioxygenase activity
TOL_RS11725	COG2081	HI0933 family
TOL_RS11735	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TOL_RS11740	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOL_RS11745	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOL_RS11750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TOL_RS11785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TOL_RS11790	COG0233	cytoplasmic translational termination
TOL_RS11795	COG0528	UMP kinase activity
TOL_RS11800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TOL_RS11805	COG0052	Belongs to the universal ribosomal protein uS2 family
TOL_RS11810	COG0024	Methionine aminopeptidase
TOL_RS11815	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TOL_RS11820	COG1741	Belongs to the pirin family
TOL_RS11825	COG0513	Belongs to the DEAD box helicase family
TOL_RS11855	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TOL_RS11860	COG0602	queuosine metabolic process
TOL_RS11865	COG3321	synthase
TOL_RS11865	COG0604	alcohol dehydrogenase
TOL_RS11885	COG0189	ligase activity
TOL_RS11890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TOL_RS11895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TOL_RS11905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TOL_RS11910	COG0840	transmembrane signaling receptor activity
TOL_RS11915	COG0583	DNA-binding transcription factor activity
TOL_RS11920	COG2205	protein histidine kinase activity
TOL_RS11925	COG0745	RESPONSE REGULATOR receiver
TOL_RS11930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TOL_RS11945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TOL_RS11980	COG0835	chemotaxis
TOL_RS11995	COG1192	Involved in chromosome partitioning
TOL_RS12000	COG2201	protein-glutamate methylesterase activity
TOL_RS12005	COG0784	Response regulator, receiver
TOL_RS12005	COG2198	Histidine kinase
TOL_RS12005	COG0643	Histidine kinase
TOL_RS12010	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
TOL_RS12040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TOL_RS12045	COG1684	flagellar biosynthetic protein fliR
TOL_RS12050	COG1987	bacterial-type flagellum assembly
TOL_RS12105	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TOL_RS12115	COG0840	transmembrane signaling receptor activity
TOL_RS12120	COG0835	chemotaxis
TOL_RS12125	COG0643	Histidine kinase
TOL_RS12125	COG2198	Histidine kinase
TOL_RS12130	COG0745	RESPONSE REGULATOR receiver
TOL_RS12165	COG1677	Flagellar hook-basal body complex protein FliE
TOL_RS12195	COG2890	protein-(glutamine-N5) methyltransferase activity
TOL_RS12200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TOL_RS12205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TOL_RS12220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TOL_RS12240	COG0489	protein tyrosine kinase activity
TOL_RS12245	COG1596	polysaccharide export
TOL_RS12265	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TOL_RS12285	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TOL_RS12330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TOL_RS12355	COG2801	Transposase and inactivated derivatives
TOL_RS12360	COG2963	transposase activity
TOL_RS12375	COG0517	IMP dehydrogenase activity
TOL_RS12375	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TOL_RS12385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TOL_RS12390	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TOL_RS12395	COG0297	glycogen (starch) synthase activity
TOL_RS12400	COG0110	maltose O-acetyltransferase activity
TOL_RS12435	COG0529	Catalyzes the synthesis of activated sulfate
TOL_RS12450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TOL_RS12470	COG1706	bacterial-type flagellum-dependent cell motility
TOL_RS12485	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TOL_RS12490	COG4786	Flagellar basal body rod
TOL_RS12495	COG4787	bacterial-type flagellum-dependent cell motility
TOL_RS12505	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TOL_RS12515	COG1815	bacterial-type flagellum-dependent cell motility
TOL_RS12525	COG0835	chemotaxis
TOL_RS12525	COG0784	Response regulator, receiver
TOL_RS12530	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
TOL_RS12590	COG1960	acyl-CoA dehydrogenase activity
TOL_RS12595	COG0393	Putative heavy-metal-binding
TOL_RS12600	COG0393	Putative heavy-metal-binding
TOL_RS12610	COG0492	ferredoxin-NADP+ reductase activity
TOL_RS12635	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TOL_RS12645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TOL_RS12645	COG4651	solute:proton antiporter activity
TOL_RS12660	COG0564	pseudouridine synthase activity
TOL_RS12670	COG0335	large ribosomal subunit rRNA binding
TOL_RS12675	COG0336	Belongs to the RNA methyltransferase TrmD family
TOL_RS12680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TOL_RS12685	COG0228	four-way junction DNA binding
TOL_RS12695	COG1283	sodium-dependent phosphate transmembrane transporter activity
TOL_RS12720	COG4372	Transposase
TOL_RS12740	COG0175	sulfate reduction
TOL_RS12755	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TOL_RS12760	COG0590	tRNA wobble adenosine to inosine editing
TOL_RS12780	COG0023	Translation Initiation Factor
TOL_RS12785	COG4191	Histidine kinase
TOL_RS12795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOL_RS12820	COG0210	DNA helicase
TOL_RS12845	COG0531	amino acid
TOL_RS12855	COG4303	Ethanolamine ammonia lyase large subunit
TOL_RS12860	COG2207	Transcriptional regulator
TOL_RS12870	COG0625	glutathione transferase activity
TOL_RS12875	COG0625	glutathione transferase activity
TOL_RS12890	COG5002	protein histidine kinase activity
TOL_RS12890	COG2198	Histidine kinase
TOL_RS12890	COG0784	Response regulator, receiver
TOL_RS12920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOL_RS12940	COG0513	Belongs to the DEAD box helicase family
TOL_RS12945	COG3123	guanosine phosphorylase activity
TOL_RS12950	COG5001	Diguanylate cyclase
TOL_RS12950	COG3300	MHYT domain
TOL_RS12955	COG3530	Putative quorum-sensing-regulated virulence factor
TOL_RS12960	COG0519	Catalyzes the synthesis of GMP from XMP
TOL_RS12960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TOL_RS12980	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TOL_RS12990	COG3630	sodium ion export across plasma membrane
TOL_RS12995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TOL_RS13000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TOL_RS13005	COG4106	trans-aconitate 2-methyltransferase activity
TOL_RS13015	COG1322	Protein conserved in bacteria
TOL_RS13025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TOL_RS13055	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TOL_RS13060	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TOL_RS13090	COG1185	polyribonucleotide nucleotidyltransferase activity
TOL_RS13095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TOL_RS13100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TOL_RS13105	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TOL_RS13110	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TOL_RS13115	COG0195	Participates in both transcription termination and antitermination
TOL_RS13120	COG0779	Required for maturation of 30S ribosomal subunits
TOL_RS13135	COG0149	triose-phosphate isomerase activity
TOL_RS13140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TOL_RS13145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TOL_RS13150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TOL_RS13155	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TOL_RS13170	COG1607	acyl-coa hydrolase
TOL_RS13185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TOL_RS13190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TOL_RS13195	COG0505	Belongs to the CarA family
TOL_RS13210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TOL_RS13215	COG0484	heat shock protein binding
TOL_RS13220	COG0443	Heat shock 70 kDa protein
TOL_RS13225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TOL_RS13230	COG0497	DNA recombination
TOL_RS13245	COG2914	Belongs to the UPF0125 (RnfH) family
TOL_RS13255	COG0733	neurotransmitter:sodium symporter activity
TOL_RS13260	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TOL_RS13295	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TOL_RS13300	COG5001	Diguanylate cyclase
TOL_RS13300	COG2203	Gaf domain
TOL_RS13300	COG4251	negative regulation of phosphorylation
TOL_RS13300	COG3706	GGDEF domain
TOL_RS13310	COG3706	GGDEF domain
TOL_RS13310	COG5001	Diguanylate cyclase
TOL_RS13310	COG2203	Gaf domain
TOL_RS13310	COG4251	negative regulation of phosphorylation
TOL_RS13315	COG0811	peptide transport
TOL_RS13320	COG0848	biopolymer transport protein
TOL_RS13335	COG4774	siderophore transport
TOL_RS13345	COG3128	pkhd-type hydroxylase
TOL_RS13365	COG1012	belongs to the aldehyde dehydrogenase family
TOL_RS13370	COG0824	Thioesterase
TOL_RS13375	COG1454	alcohol dehydrogenase
TOL_RS13380	COG1960	acyl-CoA dehydrogenase activity
TOL_RS13385	COG1024	Enoyl-CoA hydratase
TOL_RS13385	COG1250	3-hydroxyacyl-CoA dehydrogenase
TOL_RS13395	COG3046	protein related to deoxyribodipyrimidine photolyase
TOL_RS13400	COG0415	Belongs to the DNA photolyase family
TOL_RS13405	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TOL_RS13425	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TOL_RS13430	COG0069	glutamate synthase activity
TOL_RS13485	COG2801	Transposase and inactivated derivatives
TOL_RS13490	COG2963	transposase activity
TOL_RS13505	COG4372	Transposase
TOL_RS13515	COG1090	epimerase
TOL_RS13520	COG1960	acyl-CoA dehydrogenase activity
TOL_RS13525	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
TOL_RS13535	COG3272	Protein of unknown function (DUF1722)
TOL_RS13545	COG0415	Belongs to the DNA photolyase family
TOL_RS13560	COG0300	oxidoreductase activity
TOL_RS13575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TOL_RS13595	COG0583	DNA-binding transcription factor activity
TOL_RS13615	COG0587	DNA-directed DNA polymerase activity
TOL_RS13625	COG2211	Major facilitator Superfamily
TOL_RS13630	COG1666	GTP binding
TOL_RS13645	COG5002	protein histidine kinase activity
TOL_RS13650	COG4206	TonB-dependent receptor
TOL_RS13655	COG2096	Adenosyltransferase
TOL_RS13660	COG0741	lytic transglycosylase activity
TOL_RS13670	COG3239	Fatty acid desaturase
TOL_RS13675	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TOL_RS13680	COG0737	Belongs to the 5'-nucleotidase family
TOL_RS13700	COG3706	GGDEF domain
TOL_RS13705	COG0488	(ABC) transporter
TOL_RS13720	COG2863	cytochrome
TOL_RS13730	COG5001	Diguanylate cyclase
TOL_RS13730	COG3300	MHYT domain
TOL_RS13740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TOL_RS13745	COG2264	protein methyltransferase activity
TOL_RS13765	COG0138	bifunctional purine biosynthesis protein purh
TOL_RS13770	COG0151	Belongs to the GarS family
TOL_RS13775	COG0784	Response regulator, receiver
TOL_RS13775	COG2198	Histidine kinase
TOL_RS13775	COG2205	protein histidine kinase activity
TOL_RS13780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TOL_RS13785	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TOL_RS13795	COG0028	Belongs to the TPP enzyme family
TOL_RS13815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TOL_RS13815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOL_RS13865	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TOL_RS13870	COG1047	Peptidyl-prolyl cis-trans
TOL_RS13875	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TOL_RS13880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TOL_RS13885	COG0196	riboflavin kinase activity
TOL_RS13890	COG0728	peptidoglycan biosynthetic process
TOL_RS13895	COG0268	Binds directly to 16S ribosomal RNA
TOL_RS13900	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TOL_RS13905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TOL_RS13910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TOL_RS13915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TOL_RS13920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TOL_RS13925	COG0142	geranyltranstransferase activity
TOL_RS13935	COG3118	belongs to the thioredoxin family
TOL_RS13940	COG0745	RESPONSE REGULATOR receiver
TOL_RS13950	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TOL_RS13955	COG0321	lipoyl(octanoyl) transferase activity
TOL_RS13960	COG2921	Belongs to the UPF0250 family
TOL_RS13965	COG1686	Belongs to the peptidase S11 family
TOL_RS13990	COG3098	single-species biofilm formation
TOL_RS14000	COG0586	Pfam SNARE associated Golgi protein
TOL_RS14020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TOL_RS14035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TOL_RS14040	COG0768	penicillin binding
TOL_RS14045	COG0772	Belongs to the SEDS family
TOL_RS14050	COG2951	lytic endotransglycosylase activity
TOL_RS14055	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TOL_RS14100	COG0579	oxidoreductase
TOL_RS14145	COG0438	transferase activity, transferring glycosyl groups
TOL_RS14150	COG0671	phosphoesterase, PA-phosphatase related
TOL_RS14155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TOL_RS14165	COG0850	regulation of cytokinetic process
TOL_RS14170	COG2894	cell division
TOL_RS14175	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TOL_RS14210	COG2119	membrane
TOL_RS14225	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TOL_RS14265	COG2204	response regulator
TOL_RS14280	COG4796	Type ii and iii secretion system protein
TOL_RS14305	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TOL_RS14310	COG1742	UPF0060 membrane protein
TOL_RS14315	COG1742	UPF0060 membrane protein
TOL_RS14360	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TOL_RS14365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TOL_RS14370	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TOL_RS14375	COG4942	peptidase
TOL_RS14380	COG0793	Belongs to the peptidase S41A family
TOL_RS14385	COG2861	carbohydrate metabolic process
TOL_RS14405	COG0598	Magnesium transport protein CorA
TOL_RS14410	COG0417	DNA replication proofreading
TOL_RS14425	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TOL_RS14430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOL_RS14440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOL_RS14440	COG3153	acetyltransferase
TOL_RS14450	COG1489	DNA binding
TOL_RS14455	COG0436	Aminotransferase
TOL_RS14465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOL_RS14475	COG4191	Histidine kinase
TOL_RS14485	COG0617	tRNA 3'-terminal CCA addition
TOL_RS14490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TOL_RS14495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TOL_RS14500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TOL_RS14505	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TOL_RS14510	COG0166	Belongs to the GPI family
TOL_RS14515	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TOL_RS14520	COG0235	Class ii aldolase
TOL_RS14525	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TOL_RS14530	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TOL_RS14555	COG0583	DNA-binding transcription factor activity
TOL_RS14560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOL_RS14560	COG3153	acetyltransferase
TOL_RS14570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TOL_RS14575	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TOL_RS14585	COG0330	HflC and HflK could
TOL_RS14590	COG0330	HflC and HflK could
TOL_RS14595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TOL_RS14600	COG1923	regulation of RNA biosynthetic process
TOL_RS14605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TOL_RS14610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TOL_RS14615	COG0860	N-Acetylmuramoyl-L-alanine amidase
TOL_RS14620	COG0802	atpase or kinase
TOL_RS14625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TOL_RS14625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TOL_RS14635	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TOL_RS14640	COG1162	GTPase activity
TOL_RS14645	COG1360	Flagellar Motor Protein
TOL_RS14665	COG0688	phosphatidylethanolamine metabolic process
TOL_RS14670	COG0583	DNA-binding transcription factor activity
TOL_RS14695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TOL_RS14700	COG1509	lysine 2,3-aminomutase activity
TOL_RS14715	COG3830	Belongs to the UPF0237 family
TOL_RS14715	COG0560	Phosphoserine phosphatase
TOL_RS14740	COG2197	response regulator
TOL_RS14745	COG2814	Major facilitator Superfamily
TOL_RS14750	COG0629	single-stranded DNA binding
TOL_RS14770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TOL_RS14780	COG0585	pseudouridine synthase activity
TOL_RS14785	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TOL_RS14790	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TOL_RS14795	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TOL_RS14800	COG3706	GGDEF domain
TOL_RS14845	COG0504	CTP synthase activity
TOL_RS14850	COG0697	spore germination
TOL_RS14855	COG2354	Protein conserved in bacteria
TOL_RS14875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TOL_RS14880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TOL_RS14885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TOL_RS14890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TOL_RS14895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TOL_RS14900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TOL_RS14905	COG5007	Belongs to the BolA IbaG family
TOL_RS14915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TOL_RS14920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TOL_RS14925	COG1127	ABC transporter
TOL_RS14945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TOL_RS14950	COG1137	ATPase activity
TOL_RS14970	COG1660	Displays ATPase and GTPase activities
TOL_RS14975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOL_RS14980	COG2239	Acts as a magnesium transporter
TOL_RS14985	COG3028	Belongs to the UPF0307 family
TOL_RS14990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOL_RS15000	COG1530	ribonuclease E activity
TOL_RS15005	COG0424	maF-like protein
TOL_RS15010	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
TOL_RS15015	COG1792	Involved in formation and maintenance of cell shape
TOL_RS15020	COG1077	Cell shape determining protein MreB Mrl
TOL_RS15025	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TOL_RS15030	COG0154	amidase activity
TOL_RS15035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TOL_RS15055	COG4372	Transposase
TOL_RS15095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TOL_RS15100	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TOL_RS15110	COG0179	Fumarylacetoacetate (FAA) hydrolase
TOL_RS15120	COG0488	(ABC) transporter
TOL_RS15130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TOL_RS15155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TOL_RS15160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOL_RS15160	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOL_RS15175	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TOL_RS15185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TOL_RS15230	COG2072	flavoprotein involved in K transport
TOL_RS15240	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TOL_RS15245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOL_RS15250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TOL_RS15265	COG0564	pseudouridine synthase activity
TOL_RS15270	COG2267	carboxylic ester hydrolase activity
TOL_RS15280	COG2267	carboxylic ester hydrolase activity
TOL_RS15305	COG0288	reversible hydration of carbon dioxide
TOL_RS15315	COG0439	Biotin carboxylase
TOL_RS15330	COG1309	transcriptional regulator
TOL_RS15340	COG0546	phosphoglycolate phosphatase activity
TOL_RS15370	COG2409	Drug exporters of the RND superfamily
TOL_RS15385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TOL_RS15400	COG3634	alkyl hydroperoxide reductase activity
TOL_RS15425	COG0668	transmembrane transport
TOL_RS15430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOL_RS15435	COG0557	exoribonuclease II activity
TOL_RS15445	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TOL_RS15450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TOL_RS15470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOL_RS15480	COG0254	rRNA binding
TOL_RS15485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TOL_RS15490	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TOL_RS15495	COG2738	Putative neutral zinc metallopeptidase
TOL_RS15500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOL_RS15505	COG2204	response regulator
TOL_RS15510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TOL_RS15510	COG4191	Histidine kinase
TOL_RS15520	COG0142	geranyltranstransferase activity
TOL_RS15530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TOL_RS15535	COG1360	Flagellar Motor Protein
TOL_RS15545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TOL_RS15560	COG1320	monovalent cation:proton antiporter activity
TOL_RS15565	COG2212	antiporter activity
TOL_RS15570	COG1863	multisubunit Na H antiporter MnhE subunit
TOL_RS15575	COG0651	ATP synthesis coupled electron transport
TOL_RS15580	COG1006	Multisubunit Na H antiporter MnhC subunit
TOL_RS15585	COG2111	Na H antiporter
TOL_RS15585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TOL_RS15590	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TOL_RS15600	COG0493	'glutamate synthase
TOL_RS15605	COG0067	glutamate synthase
TOL_RS15605	COG0069	glutamate synthase activity
TOL_RS15605	COG0070	glutamate synthase
TOL_RS15615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TOL_RS15655	COG0277	FAD linked oxidase domain protein
TOL_RS15660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TOL_RS15665	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TOL_RS15670	COG1119	ATPase activity
TOL_RS15675	COG0537	adenosine 5'-monophosphoramidase activity
TOL_RS15720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TOL_RS15725	COG1183	phosphatidylcholine synthase activity
TOL_RS15730	COG0583	DNA-binding transcription factor activity
TOL_RS15735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TOL_RS15740	COG3447	MASE1 domain protein
TOL_RS15740	COG5002	protein histidine kinase activity
TOL_RS15740	COG5001	Diguanylate cyclase
TOL_RS15745	COG0436	Aminotransferase
TOL_RS15750	COG2166	iron-sulfur cluster assembly
TOL_RS15780	COG0126	phosphoglycerate kinase activity
TOL_RS15785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TOL_RS15825	COG0402	S-adenosylhomocysteine deaminase activity
TOL_RS15835	COG2351	hydroxyisourate hydrolase activity
TOL_RS15845	COG4266	Belongs to the allantoicase family
TOL_RS15855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TOL_RS15865	COG3845	ABC transporter
TOL_RS15875	COG1079	Belongs to the binding-protein-dependent transport system permease family
TOL_RS15880	COG1957	nucleoside hydrolase
TOL_RS15885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TOL_RS15900	COG0811	peptide transport
TOL_RS15905	COG0811	peptide transport
TOL_RS15910	COG0848	biopolymer transport protein
TOL_RS15930	COG1309	transcriptional regulator
TOL_RS15955	COG1064	alcohol dehydrogenase
TOL_RS15970	COG2315	Protein conserved in bacteria
TOL_RS15975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TOL_RS16035	COG2801	Transposase and inactivated derivatives
TOL_RS16040	COG2963	transposase activity
TOL_RS16050	COG4372	Transposase
TOL_RS16150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TOL_RS16155	COG0360	Binds together with S18 to 16S ribosomal RNA
TOL_RS16190	COG0523	cobalamin synthesis protein
TOL_RS16205	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
TOL_RS16220	COG2205	protein histidine kinase activity
TOL_RS16225	COG0745	RESPONSE REGULATOR receiver
TOL_RS16235	COG0517	IMP dehydrogenase activity
TOL_RS16260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TOL_RS16300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TOL_RS16305	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
TOL_RS16310	COG0735	belongs to the Fur family
TOL_RS16320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TOL_RS16330	COG0534	Mate efflux family protein
TOL_RS16415	COG1061	Type III restriction enzyme res subunit
TOL_RS16425	COG0534	Mate efflux family protein
TOL_RS16435	COG0583	DNA-binding transcription factor activity
TOL_RS16440	COG3038	cytochrome b561
TOL_RS16445	COG2353	YceI-like domain
TOL_RS16460	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TOL_RS16490	COG1294	oxidase, subunit
TOL_RS16505	COG2200	EAL domain
TOL_RS16505	COG2199	diguanylate cyclase activity
TOL_RS16525	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TOL_RS16525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TOL_RS16535	COG0203	ribosomal protein L17
TOL_RS16540	COG0202	RNA polymerase activity
TOL_RS16545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TOL_RS16555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TOL_RS16565	COG0200	Binds to the 23S rRNA
TOL_RS16570	COG1841	ribosomal large subunit assembly
TOL_RS16575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TOL_RS16585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TOL_RS16590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TOL_RS16595	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TOL_RS16600	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TOL_RS16605	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TOL_RS16610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TOL_RS16615	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TOL_RS16620	COG0255	Belongs to the universal ribosomal protein uL29 family
TOL_RS16630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TOL_RS16635	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TOL_RS16640	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TOL_RS16645	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TOL_RS16650	COG0089	rRNA binding
TOL_RS16655	COG0088	Forms part of the polypeptide exit tunnel
TOL_RS16665	COG0051	transcription antitermination factor activity, RNA binding
TOL_RS16670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TOL_RS16675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TOL_RS16680	COG0049	tRNA binding
TOL_RS16685	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TOL_RS16695	COG0085	RNA polymerase activity
TOL_RS16700	COG0222	ribosome binding
TOL_RS16705	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TOL_RS16710	COG0081	regulation of translation
TOL_RS16715	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TOL_RS16735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TOL_RS16740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TOL_RS16745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TOL_RS16770	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TOL_RS16775	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TOL_RS16775	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TOL_RS16780	COG4953	penicillin-binding protein 1C
TOL_RS16785	COG2373	Large extracellular alpha-helical protein
TOL_RS16810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TOL_RS16830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TOL_RS16830	COG2169	Transcriptional regulator
TOL_RS16860	COG4372	Transposase
TOL_RS16885	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TOL_RS16900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TOL_RS16935	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TOL_RS16995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TOL_RS17000	COG0746	molybdenum cofactor guanylyltransferase activity
TOL_RS17005	COG0521	Mo-molybdopterin cofactor biosynthetic process
TOL_RS17010	COG0315	cyclic pyranopterin monophosphate synthase activity
TOL_RS17015	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TOL_RS17020	COG0314	molybdopterin synthase activity
TOL_RS17035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TOL_RS17050	COG1872	DUF167
TOL_RS17055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TOL_RS17060	COG2813	Specifically methylates the guanine in position
TOL_RS17060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TOL_RS17070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TOL_RS17080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TOL_RS17085	COG4667	esterase of the alpha-beta hydrolase superfamily
TOL_RS17095	COG0527	aspartate kinase activity
TOL_RS17100	COG1917	Cupin 2, conserved barrel domain protein
TOL_RS17115	COG1846	Transcriptional regulator
TOL_RS17145	COG0534	Mate efflux family protein
TOL_RS17165	COG2840	Smr protein MutS2
TOL_RS17170	COG0204	Acyl-transferase
TOL_RS17175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TOL_RS17180	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TOL_RS17205	COG3118	belongs to the thioredoxin family
TOL_RS17215	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TOL_RS17220	COG0210	DNA helicase
TOL_RS17225	COG1737	Transcriptional regulator
TOL_RS17230	COG0004	ammonium transporteR
TOL_RS17235	COG0347	Belongs to the P(II) protein family
TOL_RS17255	COG0411	ABC transporter
TOL_RS17275	COG1802	Transcriptional regulator
TOL_RS17295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TOL_RS17300	COG3025	triphosphatase activity
TOL_RS17375	COG0730	response to heat
TOL_RS17390	COG3108	Peptidase M15
TOL_RS17395	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
TOL_RS17400	COG0494	nUDIX hydrolase
TOL_RS17425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TOL_RS17430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TOL_RS17435	COG0006	proline dipeptidase activity
TOL_RS17455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TOL_RS17480	COG1217	gtp-binding protein TYPA
TOL_RS17490	COG0281	malic enzyme
TOL_RS17500	COG0745	RESPONSE REGULATOR receiver
TOL_RS17505	COG0628	permease
TOL_RS17520	COG1346	cytolysis
TOL_RS17530	COG0494	nUDIX hydrolase
TOL_RS17535	COG1011	Hydrolase
TOL_RS17540	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TOL_RS17545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TOL_RS17550	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TOL_RS17555	COG2183	response to ionizing radiation
TOL_RS17560	COG2918	glutathione biosynthetic process
TOL_RS17570	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TOL_RS17595	COG2015	COG2015, Alkyl sulfatase and related hydrolases
TOL_RS17605	COG2832	Protein of unknown function (DUF454)
TOL_RS17615	COG0488	(ABC) transporter
TOL_RS17630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TOL_RS17635	COG2363	Small membrane protein
TOL_RS17640	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TOL_RS17650	COG0668	transmembrane transport
TOL_RS17675	COG1234	tRNA 3'-trailer cleavage
TOL_RS17715	COG0492	ferredoxin-NADP+ reductase activity
TOL_RS17740	COG0181	hydroxymethylbilane synthase activity
TOL_RS17755	COG0165	Argininosuccinate lyase
TOL_RS17775	COG2308	Evidence 4 Homologs of previously reported genes of
TOL_RS17775	COG2307	Protein conserved in bacteria
TOL_RS17790	COG2308	Evidence 4 Homologs of previously reported genes of
TOL_RS17810	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
TOL_RS17830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TOL_RS17835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TOL_RS17845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TOL_RS17855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TOL_RS17865	COG0356	it plays a direct role in the translocation of protons across the membrane
TOL_RS17880	COG1475	DNA binding
TOL_RS17885	COG1192	Involved in chromosome partitioning
TOL_RS17890	COG0357	Ribosomal RNA small subunit methyltransferase G
TOL_RS17935	COG3002	Belongs to the UPF0753 family
TOL_RS17940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TOL_RS17945	COG0583	DNA-binding transcription factor activity
TOL_RS17965	COG0445	tRNA wobble uridine modification
TOL_RS17995	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TOL_RS18000	COG0706	membrane insertase activity
TOL_RS18005	COG0594	ribonuclease P activity
TOL_RS18010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TOL_RS18025	COG3706	GGDEF domain
TOL_RS18025	COG4251	negative regulation of phosphorylation
TOL_RS18025	COG5001	Diguanylate cyclase
TOL_RS18025	COG2203	Gaf domain
TOL_RS18030	COG1404	Belongs to the peptidase S8 family
TOL_RS18045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TOL_RS18050	COG3562	capsule polysaccharide
TOL_RS18130	COG2203	Gaf domain
TOL_RS18130	COG3706	GGDEF domain
TOL_RS18130	COG4251	negative regulation of phosphorylation
TOL_RS18130	COG5001	Diguanylate cyclase
TOL_RS18135	COG3300	MHYT domain
TOL_RS18135	COG5001	Diguanylate cyclase
TOL_RS18140	COG2226	methyltransferase
TOL_RS18150	COG1309	transcriptional regulator
TOL_RS18155	COG3107	peptidoglycan biosynthetic process
TOL_RS18260	COG1309	transcriptional regulator
TOL_RS18330	COG3267	Type II secretory pathway component ExeA
TOL_RS18330	COG3409	Peptidoglycan-binding domain 1 protein
TOL_RS18340	COG5002	protein histidine kinase activity
TOL_RS18340	COG2205	protein histidine kinase activity
TOL_RS18340	COG0784	Response regulator, receiver
TOL_RS18345	COG3920	Histidine kinase
TOL_RS18370	COG2205	protein histidine kinase activity
TOL_RS18370	COG2202	Pas domain
TOL_RS18400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TOL_RS18405	COG2205	protein histidine kinase activity
TOL_RS18405	COG5002	protein histidine kinase activity
TOL_RS18405	COG0784	Response regulator, receiver
TOL_RS18410	COG2885	chlorophyll binding
TOL_RS18415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TOL_RS18455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TOL_RS18470	COG1404	Belongs to the peptidase S8 family
TOL_RS18475	COG2203	Gaf domain
TOL_RS18475	COG3706	GGDEF domain
TOL_RS18475	COG4251	negative regulation of phosphorylation
TOL_RS18475	COG5001	Diguanylate cyclase
TOL_RS18485	COG0789	Transcriptional regulator
TOL_RS18565	COG1404	Belongs to the peptidase S8 family
TOL_RS18590	COG2959	enzyme of heme biosynthesis