locus-tag	class	description
DY252_RS00025	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DY252_RS00040	COG1063	alcohol dehydrogenase
DY252_RS00055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_RS00060	COG1802	Transcriptional regulator
DY252_RS00065	COG1312	Catalyzes the dehydration of D-mannonate
DY252_RS00070	COG0246	Mannitol dehydrogenase
DY252_RS00075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DY252_RS00080	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DY252_RS00125	COG2226	methyltransferase
DY252_RS00150	COG1846	Transcriptional regulator
DY252_RS00155	COG0438	transferase activity, transferring glycosyl groups
DY252_RS00160	COG0154	amidase activity
DY252_RS00165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DY252_RS00170	COG4172	Belongs to the ABC transporter superfamily
DY252_RS00175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DY252_RS00180	COG0601	transmembrane transport
DY252_RS00190	COG0235	Class ii aldolase
DY252_RS00205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DY252_RS00210	COG1070	Carbohydrate kinase
DY252_RS00215	COG3254	rhamnose metabolic process
DY252_RS00230	COG1129	ABC transporter
DY252_RS00240	COG1349	DNA-binding transcription factor activity
DY252_RS00245	COG3347	Dehydrogenase
DY252_RS00245	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS00250	COG4952	isomerase
DY252_RS00295	COG0789	Transcriptional regulator
DY252_RS00305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DY252_RS00310	COG1999	signal sequence binding
DY252_RS00315	COG2847	Copper chaperone PCu(A)C
DY252_RS00325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DY252_RS00330	COG1999	signal sequence binding
DY252_RS00355	COG1321	iron dependent repressor
DY252_RS00375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DY252_RS00380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DY252_RS00395	COG1999	signal sequence binding
DY252_RS00410	COG0785	Cytochrome C biogenesis protein
DY252_RS00435	COG0789	Transcriptional regulator
DY252_RS00460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DY252_RS00485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DY252_RS00505	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DY252_RS00550	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DY252_RS00565	COG4191	Histidine kinase
DY252_RS00580	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DY252_RS00590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DY252_RS00595	COG0268	Binds directly to 16S ribosomal RNA
DY252_RS00600	COG1024	Enoyl-CoA hydratase
DY252_RS00605	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DY252_RS00610	COG0730	response to heat
DY252_RS00615	COG2814	Major facilitator Superfamily
DY252_RS00630	COG0776	regulation of translation
DY252_RS00635	COG0616	signal peptide processing
DY252_RS00640	COG0539	negative regulation of cytoplasmic translation
DY252_RS00675	COG1309	transcriptional regulator
DY252_RS00680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DY252_RS00685	COG0235	Class ii aldolase
DY252_RS00700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DY252_RS00715	COG0519	Catalyzes the synthesis of GMP from XMP
DY252_RS00715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DY252_RS00735	COG1234	tRNA 3'-trailer cleavage
DY252_RS00750	COG2983	Belongs to the UPF0260 family
DY252_RS00760	COG1999	signal sequence binding
DY252_RS00775	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DY252_RS00785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DY252_RS00815	COG1492	cobalamin metabolic process
DY252_RS00855	COG0588	phosphoglycerate mutase activity
DY252_RS00860	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DY252_RS00865	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DY252_RS00875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DY252_RS00895	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DY252_RS00900	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DY252_RS00930	COG2308	Evidence 4 Homologs of previously reported genes of
DY252_RS00940	COG1305	Transglutaminase-like
DY252_RS00950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DY252_RS00995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DY252_RS01000	COG1120	ATPase activity
DY252_RS01005	COG4303	Ethanolamine ammonia lyase large subunit
DY252_RS01010	COG4302	ethanolamine ammonia-lyase activity
DY252_RS01020	COG1592	Rubrerythrin
DY252_RS01035	COG1185	polyribonucleotide nucleotidyltransferase activity
DY252_RS01040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DY252_RS01045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DY252_RS01050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DY252_RS01060	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DY252_RS01075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DY252_RS01080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DY252_RS01085	COG1396	sequence-specific DNA binding
DY252_RS01090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DY252_RS01095	COG1253	flavin adenine dinucleotide binding
DY252_RS01105	COG1702	phosphate starvation-inducible protein PhoH
DY252_RS01110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DY252_RS01140	COG1214	PFAM Peptidase M22, glycoprotease
DY252_RS01145	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DY252_RS01155	COG0395	ABC-type sugar transport system, permease component
DY252_RS01160	COG1175	transmembrane transport
DY252_RS01165	COG1653	transport
DY252_RS01170	COG2723	6-phospho-beta-galactosidase activity
DY252_RS01175	COG1609	Transcriptional regulator
DY252_RS01180	COG1285	pathogenesis
DY252_RS01190	COG1280	lysine exporter protein (LysE YggA)
DY252_RS01200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DY252_RS01210	COG1959	2 iron, 2 sulfur cluster binding
DY252_RS01215	COG0756	dUTP diphosphatase activity
DY252_RS01220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DY252_RS01235	COG5002	protein histidine kinase activity
DY252_RS01240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DY252_RS01250	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DY252_RS01255	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DY252_RS01280	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DY252_RS01315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DY252_RS01325	COG0583	DNA-binding transcription factor activity
DY252_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS01355	COG0667	Aldo Keto reductase
DY252_RS01365	COG0583	DNA-binding transcription factor activity
DY252_RS01370	COG0606	chelatase, subunit chli
DY252_RS01390	COG1846	Transcriptional regulator
DY252_RS01410	COG0625	glutathione transferase activity
DY252_RS01475	COG3030	protein affecting phage T7 exclusion by the F plasmid
DY252_RS01480	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DY252_RS01500	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DY252_RS01520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DY252_RS01540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DY252_RS01555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DY252_RS01580	COG1331	Highly conserved protein containing a thioredoxin domain
DY252_RS01590	COG3411	Ferredoxin
DY252_RS01595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DY252_RS01600	COG0445	tRNA wobble uridine modification
DY252_RS01655	COG0352	thiamine-phosphate diphosphorylase activity
DY252_RS01665	COG0745	RESPONSE REGULATOR receiver
DY252_RS01690	COG0180	Tryptophanyl-tRNA synthetase
DY252_RS01705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DY252_RS01715	COG0281	malic enzyme
DY252_RS01715	COG0280	phosphate acetyltransferase
DY252_RS01730	COG2992	FlgJ-related protein
DY252_RS01735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DY252_RS01750	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DY252_RS01755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DY252_RS01760	COG1216	Glycosyl transferase, family 2
DY252_RS01800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DY252_RS01805	COG1420	regulation of RNA biosynthetic process
DY252_RS01810	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DY252_RS01815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DY252_RS01820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DY252_RS01840	COG1696	Membrane protein involved in D-alanine export
DY252_RS01870	COG1137	ATPase activity
DY252_RS01875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DY252_RS01880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DY252_RS01885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DY252_RS01890	COG2211	Major facilitator Superfamily
DY252_RS01900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DY252_RS01925	COG0792	nuclease activity
DY252_RS01930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DY252_RS01940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DY252_RS01950	COG0443	Heat shock 70 kDa protein
DY252_RS01960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DY252_RS01965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DY252_RS01965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DY252_RS01985	COG0285	dihydrofolate synthase activity
DY252_RS01990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DY252_RS02000	COG0133	tryptophan synthase activity
DY252_RS02010	COG1131	(ABC) transporter
DY252_RS02020	COG2267	carboxylic ester hydrolase activity
DY252_RS02040	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DY252_RS02045	COG0028	Belongs to the TPP enzyme family
DY252_RS02060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DY252_RS02070	COG3706	GGDEF domain
DY252_RS02070	COG5001	Diguanylate cyclase
DY252_RS02070	COG2203	Gaf domain
DY252_RS02070	COG4251	negative regulation of phosphorylation
DY252_RS02080	COG0745	RESPONSE REGULATOR receiver
DY252_RS02080	COG4191	Histidine kinase
DY252_RS02080	COG2205	protein histidine kinase activity
DY252_RS02090	COG4566	intracellular signal transduction
DY252_RS02100	COG1741	Belongs to the pirin family
DY252_RS02105	COG0583	DNA-binding transcription factor activity
DY252_RS02130	COG3842	ATPase activity
DY252_RS02145	COG4208	sulfate ABC transporter
DY252_RS02155	COG2186	Transcriptional regulator
DY252_RS02160	COG0730	response to heat
DY252_RS02215	COG1024	Enoyl-CoA hydratase
DY252_RS02225	COG1960	acyl-CoA dehydrogenase activity
DY252_RS02230	COG1250	3-hydroxyacyl-CoA dehydrogenase
DY252_RS02230	COG1024	Enoyl-CoA hydratase
DY252_RS02245	COG0318	PFAM AMP-dependent synthetase and ligase
DY252_RS02265	COG4520	surface antigen
DY252_RS02275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DY252_RS02285	COG2807	transmembrane transport
DY252_RS02295	COG4771	TonB-dependent receptor
DY252_RS02300	COG3720	iron ion transport
DY252_RS02305	COG4558	Periplasmic binding protein
DY252_RS02310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DY252_RS02315	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DY252_RS02320	COG0583	DNA-binding transcription factor activity
DY252_RS02335	COG1012	belongs to the aldehyde dehydrogenase family
DY252_RS02340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DY252_RS02350	COG0352	thiamine-phosphate diphosphorylase activity
DY252_RS02360	COG2183	response to ionizing radiation
DY252_RS02370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DY252_RS02380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DY252_RS02390	COG5383	Protein conserved in bacteria
DY252_RS02395	COG0138	bifunctional purine biosynthesis protein purh
DY252_RS02415	COG0181	hydroxymethylbilane synthase activity
DY252_RS02425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DY252_RS02430	COG2350	Protein conserved in bacteria
DY252_RS02450	COG0438	transferase activity, transferring glycosyl groups
DY252_RS02460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DY252_RS02465	COG0745	RESPONSE REGULATOR receiver
DY252_RS02470	COG0679	Auxin Efflux Carrier
DY252_RS02475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DY252_RS02480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DY252_RS02485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DY252_RS02490	COG0072	phenylalanine-tRNA ligase activity
DY252_RS02500	COG4251	negative regulation of phosphorylation
DY252_RS02515	COG4702	Belongs to the UPF0303 family
DY252_RS02530	COG0802	atpase or kinase
DY252_RS02540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DY252_RS02550	COG1074	ATP-dependent DNA helicase activity
DY252_RS02560	COG0840	transmembrane signaling receptor activity
DY252_RS02575	COG0004	ammonium transporteR
DY252_RS02580	COG0004	ammonium transporteR
DY252_RS02590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DY252_RS02595	COG3047	cAMP biosynthetic process
DY252_RS02605	COG2835	tetraacyldisaccharide 4'-kinase activity
DY252_RS02615	COG3118	belongs to the thioredoxin family
DY252_RS02640	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DY252_RS02645	COG2902	Dehydrogenase
DY252_RS02650	COG1309	transcriptional regulator
DY252_RS02655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DY252_RS02675	COG0501	Belongs to the peptidase M48B family
DY252_RS02685	COG0670	Belongs to the BI1 family
DY252_RS02695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DY252_RS02700	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DY252_RS02705	COG4181	ATPase activity
DY252_RS02725	COG0667	Aldo Keto reductase
DY252_RS02730	COG1741	Belongs to the pirin family
DY252_RS02740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DY252_RS02750	COG0697	spore germination
DY252_RS02755	COG1846	Transcriptional regulator
DY252_RS02830	COG4166	transmembrane transport
DY252_RS02835	COG4174	ABC transporter (Permease)
DY252_RS02840	COG4239	(ABC) transporter, permease
DY252_RS02845	COG4172	Belongs to the ABC transporter superfamily
DY252_RS02865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DY252_RS02875	COG1573	uracil-dna glycosylase
DY252_RS02880	COG2154	pterin-4-alpha-carbinolamine dehydratase
DY252_RS02890	COG0697	spore germination
DY252_RS02895	COG0697	spore germination
DY252_RS02900	COG0697	spore germination
DY252_RS02905	COG1522	sequence-specific DNA binding
DY252_RS02910	COG3263	regulation of cellular component size
DY252_RS02925	COG1280	lysine exporter protein (LysE YggA)
DY252_RS02945	COG3474	cytochrome
DY252_RS02950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DY252_RS02965	COG0513	Belongs to the DEAD box helicase family
DY252_RS02980	COG1960	acyl-CoA dehydrogenase activity
DY252_RS02985	COG0183	Belongs to the thiolase family
DY252_RS03000	COG0288	reversible hydration of carbon dioxide
DY252_RS03005	COG1960	acyl-CoA dehydrogenase activity
DY252_RS03010	COG3550	peptidyl-serine autophosphorylation
DY252_RS03020	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DY252_RS03025	COG1842	Phage shock protein A
DY252_RS03060	COG2301	Belongs to the HpcH HpaI aldolase family
DY252_RS03065	COG2030	dehydratase
DY252_RS03085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DY252_RS03095	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DY252_RS03100	COG4266	Belongs to the allantoicase family
DY252_RS03125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DY252_RS03125	COG2010	Cytochrome c
DY252_RS03135	COG0590	tRNA wobble adenosine to inosine editing
DY252_RS03140	COG1129	ABC transporter
DY252_RS03185	COG0583	DNA-binding transcription factor activity
DY252_RS03195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DY252_RS03220	COG0411	ABC transporter
DY252_RS03230	COG0829	nickel cation binding
DY252_RS03235	COG0831	urea catabolic process
DY252_RS03240	COG0832	Belongs to the urease beta subunit family
DY252_RS03245	COG0804	urea catabolic process
DY252_RS03250	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DY252_RS03255	COG0830	nickel cation binding
DY252_RS03260	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DY252_RS03270	COG0640	Transcriptional regulator
DY252_RS03275	COG1268	BioY protein
DY252_RS03280	COG1122	ATPase activity
DY252_RS03285	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DY252_RS03295	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DY252_RS03300	COG0583	DNA-binding transcription factor activity
DY252_RS03310	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS03335	COG0617	tRNA 3'-terminal CCA addition
DY252_RS03335	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DY252_RS03335	COG0517	IMP dehydrogenase activity
DY252_RS03350	COG2095	MarC family integral membrane protein
DY252_RS03360	COG0501	Belongs to the peptidase M48B family
DY252_RS03370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DY252_RS03645	COG1703	isobutyryl-CoA mutase activity
DY252_RS03665	COG3186	Phenylalanine-4-hydroxylase
DY252_RS03670	COG1522	sequence-specific DNA binding
DY252_RS03685	COG0745	RESPONSE REGULATOR receiver
DY252_RS03685	COG4191	Histidine kinase
DY252_RS03685	COG2205	protein histidine kinase activity
DY252_RS03690	COG2204	response regulator
DY252_RS03695	COG4753	response regulator
DY252_RS03695	COG2207	Transcriptional regulator
DY252_RS03715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DY252_RS03720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DY252_RS03770	COG1058	Belongs to the CinA family
DY252_RS03770	COG1546	Belongs to the CinA family
DY252_RS03785	COG0778	Nitroreductase
DY252_RS03820	COG1968	undecaprenyl-diphosphatase activity
DY252_RS03850	COG0747	negative chemotaxis
DY252_RS03875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DY252_RS03890	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DY252_RS03895	COG0277	FAD linked oxidase domain protein
DY252_RS03900	COG0277	FAD linked oxidase domain protein
DY252_RS03905	COG0247	lactate metabolic process
DY252_RS03915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DY252_RS03920	COG0573	inorganic phosphate transmembrane transporter activity
DY252_RS03925	COG0581	inorganic phosphate transmembrane transporter activity
DY252_RS03940	COG0745	RESPONSE REGULATOR receiver
DY252_RS03955	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS03960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DY252_RS03970	COG2233	PERMEase
DY252_RS03975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DY252_RS03980	COG0314	molybdopterin synthase activity
DY252_RS03995	COG2813	Specifically methylates the guanine in position
DY252_RS03995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DY252_RS04000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DY252_RS04015	COG0287	Prephenate dehydrogenase
DY252_RS04020	COG0697	spore germination
DY252_RS04035	COG0204	Acyl-transferase
DY252_RS04050	COG2884	Cell division ATP-binding protein ftsE
DY252_RS04065	COG1595	DNA-templated transcription, initiation
DY252_RS04070	COG3712	iron ion homeostasis
DY252_RS04085	COG0019	diaminopimelate decarboxylase activity
DY252_RS04090	COG0165	Argininosuccinate lyase
DY252_RS04095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DY252_RS04100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DY252_RS04105	COG1070	Carbohydrate kinase
DY252_RS04110	COG1250	3-hydroxyacyl-CoA dehydrogenase
DY252_RS04125	COG2096	Adenosyltransferase
DY252_RS04135	COG3604	Transcriptional regulator
DY252_RS04140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DY252_RS04145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DY252_RS04150	COG1116	anion transmembrane transporter activity
DY252_RS04155	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
DY252_RS04160	COG0625	glutathione transferase activity
DY252_RS04185	COG0604	alcohol dehydrogenase
DY252_RS04190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DY252_RS04190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DY252_RS04195	COG1309	transcriptional regulator
DY252_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS04210	COG0328	RNA-DNA hybrid ribonuclease activity
DY252_RS04215	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DY252_RS04220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DY252_RS04230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DY252_RS04235	COG0509	glycine decarboxylation via glycine cleavage system
DY252_RS04240	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DY252_RS04245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DY252_RS04260	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DY252_RS04260	COG0678	peroxiredoxin activity
DY252_RS04270	COG1678	Uncharacterized ACR, COG1678
DY252_RS04280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DY252_RS04290	COG0109	protoheme IX farnesyltransferase activity
DY252_RS04295	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DY252_RS04315	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DY252_RS04320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DY252_RS04330	COG0612	Peptidase, M16
DY252_RS04365	COG1473	amidohydrolase
DY252_RS04380	COG0583	DNA-binding transcription factor activity
DY252_RS04390	COG1012	belongs to the aldehyde dehydrogenase family
DY252_RS04400	COG1573	uracil-dna glycosylase
DY252_RS04405	COG0741	lytic transglycosylase activity
DY252_RS04420	COG3088	subunit of a heme lyase
DY252_RS04425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DY252_RS04430	COG1138	Cytochrome C-type biogenesis protein
DY252_RS04435	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DY252_RS04445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DY252_RS04450	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DY252_RS04465	COG0733	neurotransmitter:sodium symporter activity
DY252_RS04470	COG5001	Diguanylate cyclase
DY252_RS04470	COG3300	MHYT domain
DY252_RS04520	COG0701	Predicted permease
DY252_RS04530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DY252_RS04530	COG2111	Na H antiporter
DY252_RS04535	COG1006	Multisubunit Na H antiporter MnhC subunit
DY252_RS04540	COG0651	ATP synthesis coupled electron transport
DY252_RS04545	COG1863	multisubunit Na H antiporter MnhE subunit
DY252_RS04550	COG2212	antiporter activity
DY252_RS04555	COG1320	monovalent cation:proton antiporter activity
DY252_RS04560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DY252_RS04575	COG2832	Protein of unknown function (DUF454)
DY252_RS04585	COG4251	negative regulation of phosphorylation
DY252_RS04645	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DY252_RS04660	COG0583	DNA-binding transcription factor activity
DY252_RS04665	COG1960	acyl-CoA dehydrogenase activity
DY252_RS04670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DY252_RS04675	COG3842	ATPase activity
DY252_RS04680	COG1176	ABC-type spermidine putrescine transport system, permease component I
DY252_RS04685	COG1177	transmembrane transport
DY252_RS04690	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DY252_RS04700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DY252_RS04710	COG2207	Transcriptional regulator
DY252_RS04725	COG2207	Transcriptional regulator
DY252_RS04770	COG5001	Diguanylate cyclase
DY252_RS04770	COG3300	MHYT domain
DY252_RS04775	COG4942	peptidase
DY252_RS04785	COG2226	methyltransferase
DY252_RS04790	COG2030	dehydratase
DY252_RS04795	COG0196	riboflavin kinase activity
DY252_RS04805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DY252_RS04815	COG0612	Peptidase, M16
DY252_RS04820	COG0612	Peptidase, M16
DY252_RS04825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DY252_RS04840	COG1360	Flagellar Motor Protein
DY252_RS04845	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DY252_RS04855	COG2375	cellular response to nickel ion
DY252_RS04860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DY252_RS04865	COG1321	iron dependent repressor
DY252_RS04865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DY252_RS04870	COG1121	(ABC) transporter
DY252_RS04875	COG0803	Belongs to the bacterial solute-binding protein 9 family
DY252_RS04900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DY252_RS04900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DY252_RS04910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DY252_RS04930	COG0367	asparagine synthase
DY252_RS04935	COG0438	transferase activity, transferring glycosyl groups
DY252_RS04960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DY252_RS04970	COG1086	Polysaccharide biosynthesis protein
DY252_RS04975	COG2089	acid synthase
DY252_RS04980	COG1132	(ABC) transporter
DY252_RS04990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DY252_RS04995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DY252_RS05000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DY252_RS05010	COG1396	sequence-specific DNA binding
DY252_RS05030	COG3243	poly(R)-hydroxyalkanoic acid synthase
DY252_RS05040	COG1522	sequence-specific DNA binding
DY252_RS05050	COG2132	Multicopper oxidase
DY252_RS05080	COG1072	(Pantothenic acid kinase))
DY252_RS05105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DY252_RS05135	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DY252_RS05155	COG0010	Belongs to the arginase family
DY252_RS05165	COG0583	DNA-binding transcription factor activity
DY252_RS05170	COG3119	arylsulfatase activity
DY252_RS05180	COG0693	protein deglycase activity
DY252_RS05190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DY252_RS05195	COG1846	Transcriptional regulator
DY252_RS05200	COG0745	RESPONSE REGULATOR receiver
DY252_RS05230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DY252_RS05260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DY252_RS05285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DY252_RS05290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DY252_RS05300	COG0012	GTP binding
DY252_RS05305	COG0519	Catalyzes the synthesis of GMP from XMP
DY252_RS05305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DY252_RS05310	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DY252_RS05310	COG1618	nucleotide phosphatase activity, acting on free nucleotides
DY252_RS05315	COG1063	alcohol dehydrogenase
DY252_RS05325	COG0583	DNA-binding transcription factor activity
DY252_RS05330	COG0450	alkyl hydroperoxide reductase
DY252_RS05335	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DY252_RS05375	COG0436	Aminotransferase
DY252_RS05380	COG0556	nucleotide-excision repair
DY252_RS05385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DY252_RS05390	COG0583	DNA-binding transcription factor activity
DY252_RS05395	COG4336	lyase activity
DY252_RS05410	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_RS05420	COG0154	amidase activity
DY252_RS05440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_RS05445	COG0783	Belongs to the Dps family
DY252_RS05450	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DY252_RS05455	COG0583	DNA-binding transcription factor activity
DY252_RS05460	COG0492	ferredoxin-NADP+ reductase activity
DY252_RS05465	COG1522	sequence-specific DNA binding
DY252_RS05485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DY252_RS05495	COG0505	Belongs to the CarA family
DY252_RS05500	COG1610	YqeY-like protein
DY252_RS05505	COG0358	DNA primase activity
DY252_RS05510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DY252_RS05585	COG3561	AntA/AntB antirepressor
DY252_RS05720	COG4695	Portal protein
DY252_RS05775	COG1070	Carbohydrate kinase
DY252_RS05780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DY252_RS05785	COG3842	ATPase activity
DY252_RS05790	COG1063	alcohol dehydrogenase
DY252_RS05805	COG1175	transmembrane transport
DY252_RS05815	COG2390	Transcriptional regulator
DY252_RS05820	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS05830	COG1618	nucleotide phosphatase activity, acting on free nucleotides
DY252_RS05830	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DY252_RS05835	COG0288	reversible hydration of carbon dioxide
DY252_RS05840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DY252_RS05845	COG2181	nitrate reductase activity
DY252_RS05850	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DY252_RS05855	COG1140	nitrate reductase beta subunit
DY252_RS05860	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DY252_RS05865	COG2223	nitrite transmembrane transporter activity
DY252_RS05875	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DY252_RS05885	COG0826	peptidase U32
DY252_RS05905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DY252_RS05950	COG1609	Transcriptional regulator
DY252_RS05970	COG1879	ABC-type sugar transport system periplasmic component
DY252_RS05975	COG1129	ABC transporter
DY252_RS05980	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_RS05985	COG1129	ABC transporter
DY252_RS05990	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_RS06025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DY252_RS06050	COG0673	inositol 2-dehydrogenase activity
DY252_RS06060	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_RS06065	COG1129	ABC transporter
DY252_RS06070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DY252_RS06075	COG3962	Belongs to the TPP enzyme family
DY252_RS06085	COG3718	enzyme involved in inositol metabolism
DY252_RS06090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DY252_RS06090	COG1648	precorrin-2 dehydrogenase activity
DY252_RS06095	COG0243	molybdopterin cofactor binding
DY252_RS06100	COG2146	nitrite reductase [NAD(P)H] activity
DY252_RS06105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DY252_RS06115	COG2223	nitrite transmembrane transporter activity
DY252_RS06125	COG1116	anion transmembrane transporter activity
DY252_RS06125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DY252_RS06135	COG0446	pyridine nucleotide-disulphide oxidoreductase
DY252_RS06135	COG1902	pentaerythritol trinitrate reductase activity
DY252_RS06140	COG0583	DNA-binding transcription factor activity
DY252_RS06145	COG4638	Rieske (2fe-2S)
DY252_RS06155	COG3335	DDE superfamily endonuclease
DY252_RS06160	COG2207	Transcriptional regulator
DY252_RS06175	COG0446	pyridine nucleotide-disulphide oxidoreductase
DY252_RS06175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DY252_RS06185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DY252_RS06195	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DY252_RS06200	COG4149	molybdate abc transporter
DY252_RS06205	COG0725	ABC transporter, periplasmic molybdate-binding protein
DY252_RS06215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DY252_RS06220	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DY252_RS06220	COG0517	IMP dehydrogenase activity
DY252_RS06225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DY252_RS06235	COG0488	(ABC) transporter
DY252_RS06245	COG2853	Lipoprotein
DY252_RS06250	COG2226	methyltransferase
DY252_RS06265	COG0646	methionine synthase
DY252_RS06265	COG1410	methionine synthase
DY252_RS06270	COG2814	Major facilitator Superfamily
DY252_RS06275	COG0038	chloride channel
DY252_RS06285	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DY252_RS06290	COG0210	DNA helicase
DY252_RS06295	COG2264	protein methyltransferase activity
DY252_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS06325	COG0006	proline dipeptidase activity
DY252_RS06330	COG0667	Aldo Keto reductase
DY252_RS06340	COG0697	spore germination
DY252_RS06365	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DY252_RS06375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DY252_RS06380	COG0849	cell division
DY252_RS06385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DY252_RS06390	COG1181	Belongs to the D-alanine--D-alanine ligase family
DY252_RS06395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DY252_RS06400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DY252_RS06415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DY252_RS06430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DY252_RS06435	COG0768	penicillin binding
DY252_RS06460	COG0598	Magnesium transport protein CorA
DY252_RS06465	COG1335	isochorismatase
DY252_RS06480	COG3023	N-Acetylmuramoyl-L-alanine amidase
DY252_RS06495	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DY252_RS06515	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS06540	COG0069	glutamate synthase activity
DY252_RS06545	COG3811	Belongs to the UPF0386 family
DY252_RS06550	COG0454	-acetyltransferase
DY252_RS06550	COG0456	acetyltransferase
DY252_RS06565	COG0277	FAD linked oxidase domain protein
DY252_RS06585	COG2982	Protein involved in outer membrane biogenesis
DY252_RS06590	COG0306	phosphate transporter
DY252_RS06595	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DY252_RS06600	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DY252_RS06605	COG0343	queuine tRNA-ribosyltransferase activity
DY252_RS06610	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DY252_RS06615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DY252_RS06620	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DY252_RS06635	COG2205	protein histidine kinase activity
DY252_RS06635	COG0784	Response regulator, receiver
DY252_RS06635	COG5002	protein histidine kinase activity
DY252_RS06645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DY252_RS06650	COG3246	L-lysine catabolic process to acetate
DY252_RS06675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DY252_RS06685	COG3474	cytochrome
DY252_RS06705	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_RS06720	COG0142	geranyltranstransferase activity
DY252_RS06730	COG2890	protein-(glutamine-N5) methyltransferase activity
DY252_RS06740	COG0752	glycyl-tRNA synthetase alpha subunit
DY252_RS06750	COG0574	Belongs to the PEP-utilizing enzyme family
DY252_RS06750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DY252_RS06760	COG0354	folic acid binding
DY252_RS06775	COG0367	asparagine synthase
DY252_RS06785	COG3339	Conserved Protein
DY252_RS06790	COG0604	alcohol dehydrogenase
DY252_RS06840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DY252_RS06850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DY252_RS06870	COG1530	ribonuclease E activity
DY252_RS06875	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DY252_RS06895	COG0415	Belongs to the DNA photolyase family
DY252_RS06910	COG2313	pseudouridylate synthase activity
DY252_RS06915	COG2814	Major facilitator Superfamily
DY252_RS06920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DY252_RS06925	COG0440	acetolactate synthase activity
DY252_RS06930	COG0028	Belongs to the TPP enzyme family
DY252_RS06940	COG0560	Phosphoserine phosphatase
DY252_RS06940	COG3830	Belongs to the UPF0237 family
DY252_RS06960	COG0330	HflC and HflK could
DY252_RS06965	COG0489	protein tyrosine kinase activity
DY252_RS06975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DY252_RS06980	COG0047	phosphoribosylformylglycinamidine synthase activity
DY252_RS06985	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DY252_RS06990	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DY252_RS07005	COG2197	response regulator
DY252_RS07010	COG0504	CTP synthase activity
DY252_RS07015	COG0697	spore germination
DY252_RS07020	COG0583	DNA-binding transcription factor activity
DY252_RS07025	COG1881	PFAM PEBP family protein
DY252_RS07030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DY252_RS07035	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DY252_RS07045	COG0444	Belongs to the ABC transporter superfamily
DY252_RS07050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DY252_RS07055	COG0601	transmembrane transport
DY252_RS07060	COG4166	transmembrane transport
DY252_RS07075	COG0346	lactoylglutathione lyase activity
DY252_RS07080	COG2003	Belongs to the UPF0758 family
DY252_RS07085	COG0024	Methionine aminopeptidase
DY252_RS07090	COG1489	DNA binding
DY252_RS07105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DY252_RS07105	COG1017	nitric oxide dioxygenase activity
DY252_RS07110	COG0625	glutathione transferase activity
DY252_RS07115	COG0583	DNA-binding transcription factor activity
DY252_RS07120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DY252_RS07170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DY252_RS07195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DY252_RS07205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DY252_RS07210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DY252_RS07215	COG2890	protein-(glutamine-N5) methyltransferase activity
DY252_RS07235	COG0542	response to heat
DY252_RS07250	COG1022	Amp-dependent synthetase and ligase
DY252_RS07260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DY252_RS07295	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DY252_RS07310	COG0242	peptide deformylase activity
DY252_RS07325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DY252_RS07330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DY252_RS07375	COG0583	DNA-binding transcription factor activity
DY252_RS07380	COG1349	DNA-binding transcription factor activity
DY252_RS07390	COG3321	synthase
DY252_RS07390	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS07390	COG0604	alcohol dehydrogenase
DY252_RS07410	COG0254	rRNA binding
DY252_RS07415	COG1965	Belongs to the frataxin family
DY252_RS07420	COG1132	(ABC) transporter
DY252_RS07425	COG0739	heme binding
DY252_RS07460	COG1959	2 iron, 2 sulfur cluster binding
DY252_RS07465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DY252_RS07475	COG4208	sulfate ABC transporter
DY252_RS07480	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DY252_RS07485	COG0471	metal ion transport
DY252_RS07485	COG3273	potassium ion transport
DY252_RS07510	COG1116	anion transmembrane transporter activity
DY252_RS07515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DY252_RS07520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DY252_RS07525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DY252_RS07535	COG0471	metal ion transport
DY252_RS07535	COG3273	potassium ion transport
DY252_RS07545	COG2059	Chromate
DY252_RS07560	COG4227	nucleotidyltransferase activity
DY252_RS07570	COG1475	DNA binding
DY252_RS07595	COG0681	Belongs to the peptidase S26 family
DY252_RS07600	COG0741	lytic transglycosylase activity
DY252_RS07630	COG4962	Type ii secretion system protein e
DY252_RS07645	COG3451	type IV secretory pathway VirB4
DY252_RS07670	COG2948	multi-organism process
DY252_RS07760	COG3483	tryptophan 2,3-dioxygenase activity
DY252_RS07780	COG1129	ABC transporter
DY252_RS07800	COG1177	transmembrane transport
DY252_RS07805	COG1176	ABC-type spermidine putrescine transport system, permease component I
DY252_RS07820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DY252_RS07835	COG4221	oxidoreductase activity
DY252_RS07840	COG2204	response regulator
DY252_RS07845	COG4191	Histidine kinase
DY252_RS07855	COG2223	nitrite transmembrane transporter activity
DY252_RS07860	COG0583	DNA-binding transcription factor activity
DY252_RS07875	COG3383	formate dehydrogenase (NAD+) activity
DY252_RS07885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DY252_RS07890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DY252_RS07905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DY252_RS07915	COG1846	Transcriptional regulator
DY252_RS07915	COG1940	carbohydrate kinase activity
DY252_RS07925	COG1129	ABC transporter
DY252_RS07930	COG4214	carbohydrate transport
DY252_RS07935	COG4213	ABC transporter substrate-binding protein
DY252_RS07940	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS07945	COG0129	dihydroxy-acid dehydratase activity
DY252_RS07960	COG0069	glutamate synthase activity
DY252_RS07965	COG2218	PFAM glutamate synthase alpha subunit domain protein
DY252_RS07970	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DY252_RS07980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DY252_RS08005	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DY252_RS08015	COG4977	sequence-specific DNA binding
DY252_RS08020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_RS08025	COG4311	Sarcosine oxidase, delta subunit
DY252_RS08030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DY252_RS08030	COG0446	pyridine nucleotide-disulphide oxidoreductase
DY252_RS08065	COG2391	methyltransferase activity
DY252_RS08075	COG0513	Belongs to the DEAD box helicase family
DY252_RS08080	COG1278	Cold shock
DY252_RS08085	COG2186	Transcriptional regulator
DY252_RS08095	COG0765	amino acid transport
DY252_RS08115	COG1671	Belongs to the UPF0178 family
DY252_RS08135	COG0523	cobalamin synthesis protein
DY252_RS08140	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DY252_RS08150	COG0840	transmembrane signaling receptor activity
DY252_RS08155	COG0625	glutathione transferase activity
DY252_RS08160	COG0625	glutathione transferase activity
DY252_RS08165	COG0477	Major facilitator Superfamily
DY252_RS08170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DY252_RS08175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DY252_RS08180	COG1845	cytochrome c oxidase, subunit III
DY252_RS08185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DY252_RS08200	COG0625	glutathione transferase activity
DY252_RS08210	COG2226	methyltransferase
DY252_RS08215	COG1309	transcriptional regulator
DY252_RS08225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DY252_RS08245	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DY252_RS08245	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DY252_RS08255	COG0697	spore germination
DY252_RS08265	COG3180	Ammonia monooxygenase
DY252_RS08290	COG5001	Diguanylate cyclase
DY252_RS08305	COG1366	Belongs to the anti-sigma-factor antagonist family
DY252_RS08310	COG2204	response regulator
DY252_RS08335	COG1879	ABC-type sugar transport system periplasmic component
DY252_RS08345	COG0772	Belongs to the SEDS family
DY252_RS08350	COG0768	penicillin binding
DY252_RS08375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DY252_RS08380	COG1280	lysine exporter protein (LysE YggA)
DY252_RS08395	COG3706	GGDEF domain
DY252_RS08405	COG1278	Cold shock
DY252_RS08410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DY252_RS08435	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DY252_RS08440	COG0840	transmembrane signaling receptor activity
DY252_RS08450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DY252_RS08450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DY252_RS08460	COG0519	Catalyzes the synthesis of GMP from XMP
DY252_RS08480	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS08490	COG3655	Transcriptional regulator
DY252_RS08505	COG2217	Heavy metal translocating P-type atpase
DY252_RS08510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DY252_RS08520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DY252_RS08525	COG0765	amino acid transport
DY252_RS08530	COG0765	amino acid transport
DY252_RS08580	COG1012	belongs to the aldehyde dehydrogenase family
DY252_RS08585	COG0596	Alpha beta hydrolase
DY252_RS08590	COG0494	nUDIX hydrolase
DY252_RS08610	COG1653	transport
DY252_RS08625	COG0366	Alpha amylase catalytic
DY252_RS08630	COG3842	ATPase activity
DY252_RS08635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DY252_RS08640	COG0363	glucosamine-6-phosphate deaminase activity
DY252_RS08645	COG0129	dihydroxy-acid dehydratase activity
DY252_RS08650	COG0837	glucose binding
DY252_RS08655	COG0800	Aldolase
DY252_RS08670	COG1595	DNA-templated transcription, initiation
DY252_RS08710	COG2719	SpoVR family
DY252_RS08715	COG2718	Belongs to the UPF0229 family
DY252_RS08720	COG2766	serine protein kinase
DY252_RS08735	COG0251	oxidation-reduction process
DY252_RS08755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DY252_RS08795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DY252_RS08810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DY252_RS08820	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DY252_RS08830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DY252_RS08840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DY252_RS08845	COG0222	ribosome binding
DY252_RS08850	COG0085	RNA polymerase activity
DY252_RS08855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DY252_RS08875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DY252_RS08885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DY252_RS08890	COG0088	Forms part of the polypeptide exit tunnel
DY252_RS08895	COG0089	rRNA binding
DY252_RS08905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DY252_RS08915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DY252_RS08920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DY252_RS08925	COG0255	Belongs to the universal ribosomal protein uL29 family
DY252_RS08940	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DY252_RS08945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DY252_RS08955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DY252_RS08965	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DY252_RS08975	COG1841	ribosomal large subunit assembly
DY252_RS08980	COG0200	Binds to the 23S rRNA
DY252_RS08985	COG0201	protein transport
DY252_RS08990	COG0563	adenylate kinase activity
DY252_RS08995	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DY252_RS09000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DY252_RS09010	COG0203	ribosomal protein L17
DY252_RS09015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DY252_RS09025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DY252_RS09030	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DY252_RS09040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DY252_RS09045	COG0564	pseudouridine synthase activity
DY252_RS09055	COG0546	phosphoglycolate phosphatase activity
DY252_RS09070	COG0412	Dienelactone hydrolase
DY252_RS09075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DY252_RS09105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DY252_RS09110	COG4770	biotin carboxylase activity
DY252_RS09130	COG1254	Belongs to the acylphosphatase family
DY252_RS09160	COG0277	FAD linked oxidase domain protein
DY252_RS09165	COG0009	L-threonylcarbamoyladenylate synthase
DY252_RS09180	COG1355	regulation of microtubule-based process
DY252_RS09205	COG0456	acetyltransferase
DY252_RS09215	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DY252_RS09220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DY252_RS09225	COG2927	DNA polymerase III (CHI subunit)
DY252_RS09230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DY252_RS09235	COG2011	ABC-type metal ion transport system permease component
DY252_RS09255	COG0477	Major facilitator Superfamily
DY252_RS09270	COG3093	addiction module antidote protein HigA
DY252_RS09275	COG3549	Plasmid maintenance system killer
DY252_RS09295	COG0488	(ABC) transporter
DY252_RS09300	COG0105	UTP biosynthetic process
DY252_RS09330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DY252_RS09335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DY252_RS09345	COG0628	permease
DY252_RS09350	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DY252_RS09355	COG4067	protein conserved in archaea
DY252_RS09355	COG0189	ligase activity
DY252_RS09360	COG0189	ligase activity
DY252_RS09370	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DY252_RS09380	COG1309	transcriptional regulator
DY252_RS09415	COG0248	Ppx GppA phosphatase
DY252_RS09450	COG0640	Transcriptional regulator
DY252_RS09460	COG0123	including yeast histone deacetylase and acetoin utilization protein
DY252_RS09480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DY252_RS09495	COG0318	PFAM AMP-dependent synthetase and ligase
DY252_RS09520	COG1802	Transcriptional regulator
DY252_RS09525	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DY252_RS09560	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DY252_RS09565	COG1295	ribonuclease BN
DY252_RS09580	COG1022	Amp-dependent synthetase and ligase
DY252_RS09590	COG3264	Mechanosensitive ion channel
DY252_RS09590	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DY252_RS09595	COG0484	heat shock protein binding
DY252_RS09600	COG4520	surface antigen
DY252_RS09625	COG2135	peptidase activity
DY252_RS09630	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS09635	COG3153	acetyltransferase
DY252_RS09650	COG0156	8-amino-7-oxononanoate synthase activity
DY252_RS09665	COG0583	DNA-binding transcription factor activity
DY252_RS09680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DY252_RS09690	COG0659	secondary active sulfate transmembrane transporter activity
DY252_RS09695	COG1024	Enoyl-CoA hydratase
DY252_RS09705	COG2814	Major facilitator Superfamily
DY252_RS09715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_RS09720	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DY252_RS09725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_RS09750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DY252_RS09765	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DY252_RS09770	COG0583	DNA-binding transcription factor activity
DY252_RS09780	COG3622	Belongs to the hyi family
DY252_RS09790	COG2186	Transcriptional regulator
DY252_RS09800	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DY252_RS09865	COG3135	benzoate transporter
DY252_RS09870	COG0450	alkyl hydroperoxide reductase
DY252_RS09895	COG0483	inositol monophosphate 1-phosphatase activity
DY252_RS09900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DY252_RS09905	COG0352	thiamine-phosphate diphosphorylase activity
DY252_RS09935	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DY252_RS09945	COG1692	metallophosphoesterase
DY252_RS09960	COG0217	transcriptional regulatory protein
DY252_RS09970	COG0632	four-way junction helicase activity
DY252_RS09975	COG2255	four-way junction helicase activity
DY252_RS09980	COG0824	Thioesterase
DY252_RS09990	COG0848	biopolymer transport protein
DY252_RS10005	COG2885	chlorophyll binding
DY252_RS10015	COG0037	tRNA processing
DY252_RS10020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DY252_RS10025	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DY252_RS10030	COG0745	RESPONSE REGULATOR receiver
DY252_RS10040	COG2205	protein histidine kinase activity
DY252_RS10045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DY252_RS10050	COG0351	phosphomethylpyrimidine kinase
DY252_RS10050	COG0352	thiamine-phosphate diphosphorylase activity
DY252_RS10070	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DY252_RS10085	COG0686	Belongs to the AlaDH PNT family
DY252_RS10090	COG1522	sequence-specific DNA binding
DY252_RS10100	COG1177	transmembrane transport
DY252_RS10105	COG1176	ABC-type spermidine putrescine transport system, permease component I
DY252_RS10110	COG3842	ATPase activity
DY252_RS10115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DY252_RS10120	COG0174	glutamine synthetase
DY252_RS10130	COG4948	Mandelate Racemase Muconate Lactonizing
DY252_RS10165	COG0842	Transport permease protein
DY252_RS10170	COG1129	ABC transporter
DY252_RS10170	COG0842	Transport permease protein
DY252_RS10175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DY252_RS10180	COG1408	metallophosphoesterase
DY252_RS10185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DY252_RS10190	COG0583	DNA-binding transcription factor activity
DY252_RS10230	COG0247	lactate metabolic process
DY252_RS10230	COG0277	FAD linked oxidase domain protein
DY252_RS10235	COG2831	hemolysin activation secretion protein
DY252_RS10250	COG1116	anion transmembrane transporter activity
DY252_RS10260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DY252_RS10275	COG3668	Plasmid stabilization system
DY252_RS10285	COG0583	DNA-binding transcription factor activity
DY252_RS10300	COG0110	maltose O-acetyltransferase activity
DY252_RS10320	COG0642	Histidine kinase
DY252_RS10325	COG1609	Transcriptional regulator
DY252_RS10335	COG4149	molybdate abc transporter
DY252_RS10345	COG3842	ATPase activity
DY252_RS10350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DY252_RS10355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DY252_RS10365	COG1090	epimerase
DY252_RS10375	COG0583	DNA-binding transcription factor activity
DY252_RS10390	COG2194	sulfuric ester hydrolase activity
DY252_RS10400	COG0432	Pfam Uncharacterised protein family UPF0047
DY252_RS10425	COG1335	isochorismatase
DY252_RS10430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DY252_RS10450	COG4765	Protein conserved in bacteria
DY252_RS10460	COG2353	YceI-like domain
DY252_RS10465	COG3038	cytochrome b561
DY252_RS10485	COG0400	carboxylic ester hydrolase activity
DY252_RS10490	COG0534	Mate efflux family protein
DY252_RS10495	COG1522	sequence-specific DNA binding
DY252_RS10505	COG1959	2 iron, 2 sulfur cluster binding
DY252_RS10510	COG0513	Belongs to the DEAD box helicase family
DY252_RS10530	COG0187	DNA topoisomerase II activity
DY252_RS10550	COG4608	Belongs to the ABC transporter superfamily
DY252_RS10555	COG0444	Belongs to the ABC transporter superfamily
DY252_RS10565	COG0601	transmembrane transport
DY252_RS10610	COG0469	pyruvate kinase activity
DY252_RS10630	COG0693	protein deglycase activity
DY252_RS10635	COG0668	transmembrane transport
DY252_RS10650	COG1832	CoA-binding protein
DY252_RS10655	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DY252_RS10665	COG1280	lysine exporter protein (LysE YggA)
DY252_RS10690	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DY252_RS10695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DY252_RS10715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DY252_RS10760	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DY252_RS10765	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DY252_RS10770	COG1858	cytochrome C peroxidase
DY252_RS10775	COG2084	Dehydrogenase
DY252_RS10780	COG3243	poly(R)-hydroxyalkanoic acid synthase
DY252_RS10790	COG0436	Aminotransferase
DY252_RS10800	COG1494	fructose-1,6-bisphosphatase
DY252_RS10805	COG0443	Heat shock 70 kDa protein
DY252_RS10820	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DY252_RS10820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DY252_RS10825	COG2223	nitrite transmembrane transporter activity
DY252_RS10845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DY252_RS10865	COG1234	tRNA 3'-trailer cleavage
DY252_RS10875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DY252_RS10880	COG0840	transmembrane signaling receptor activity
DY252_RS10880	COG2972	Histidine kinase
DY252_RS10895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DY252_RS10915	COG0626	cystathionine gamma-synthase activity
DY252_RS10920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_RS10930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DY252_RS10935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DY252_RS10940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DY252_RS10945	COG1116	anion transmembrane transporter activity
DY252_RS10965	COG0123	including yeast histone deacetylase and acetoin utilization protein
DY252_RS11000	COG0656	L-ascorbic acid biosynthetic process
DY252_RS11005	COG0523	cobalamin synthesis protein
DY252_RS11025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DY252_RS11035	COG0626	cystathionine gamma-synthase activity
DY252_RS11040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DY252_RS11045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DY252_RS11060	COG2897	thiosulfate sulfurtransferase activity
DY252_RS11065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DY252_RS11090	COG1280	lysine exporter protein (LysE YggA)
DY252_RS11095	COG1620	l-lactate permease
DY252_RS11100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DY252_RS11115	COG2814	Major facilitator Superfamily
DY252_RS11125	COG0494	nUDIX hydrolase
DY252_RS11130	COG3706	GGDEF domain
DY252_RS11140	COG2195	Cleaves the N-terminal amino acid of tripeptides
DY252_RS11145	COG0484	heat shock protein binding
DY252_RS11190	COG0730	response to heat
DY252_RS11195	COG0425	Belongs to the sulfur carrier protein TusA family
DY252_RS11200	COG2153	protein acetylation
DY252_RS11215	COG5002	protein histidine kinase activity
DY252_RS11215	COG5001	Diguanylate cyclase
DY252_RS11220	COG3706	GGDEF domain
DY252_RS11235	COG1067	ATP-dependent peptidase activity
DY252_RS11240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DY252_RS11250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DY252_RS11265	COG3273	potassium ion transport
DY252_RS11265	COG0471	metal ion transport
DY252_RS11300	COG0564	pseudouridine synthase activity
DY252_RS11315	COG4175	Glycine betaine
DY252_RS11320	COG4176	ABC-type proline glycine betaine transport system permease component
DY252_RS11340	COG1840	ABC-type Fe3 transport system, periplasmic component
DY252_RS11345	COG1840	ABC-type Fe3 transport system, periplasmic component
DY252_RS11360	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DY252_RS11405	COG0747	negative chemotaxis
DY252_RS11410	COG0601	transmembrane transport
DY252_RS11415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DY252_RS11430	COG2814	Major facilitator Superfamily
DY252_RS11435	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DY252_RS11435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_RS11440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DY252_RS11445	COG1393	Belongs to the ArsC family
DY252_RS11450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DY252_RS11455	COG0405	Gamma-glutamyltransferase
DY252_RS11480	COG0793	Belongs to the peptidase S41A family
DY252_RS11495	COG0557	exoribonuclease II activity
DY252_RS11500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DY252_RS11505	COG0758	DNA mediated transformation
DY252_RS11505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DY252_RS11535	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DY252_RS11540	COG3842	ATPase activity
DY252_RS11550	COG1176	ABC-type spermidine putrescine transport system, permease component I
DY252_RS11560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DY252_RS11565	COG0154	amidase activity
DY252_RS11570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DY252_RS11575	COG0431	NADPH-dependent FMN reductase
DY252_RS11580	COG2217	Heavy metal translocating P-type atpase
DY252_RS11590	COG0583	DNA-binding transcription factor activity
DY252_RS11610	COG2995	paraquat-inducible protein a
DY252_RS11615	COG3008	intermembrane lipid transfer
DY252_RS11675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DY252_RS11680	COG0737	Belongs to the 5'-nucleotidase family
DY252_RS11710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DY252_RS11715	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DY252_RS11725	COG1127	ABC transporter
DY252_RS11730	COG1126	abc transporter atp-binding protein
DY252_RS11735	COG0765	amino acid transport
DY252_RS11740	COG4597	amino acid ABC transporter
DY252_RS11745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DY252_RS11750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DY252_RS11755	COG0521	Mo-molybdopterin cofactor biosynthetic process
DY252_RS11780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DY252_RS11815	COG2814	Major facilitator Superfamily
DY252_RS11840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DY252_RS11850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DY252_RS11865	COG0310	cobalt ion transport
DY252_RS11900	COG1042	CoA-binding domain protein
DY252_RS11900	COG0045	succinate-CoA ligase (ADP-forming) activity
DY252_RS11900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DY252_RS11925	COG0840	transmembrane signaling receptor activity
DY252_RS11930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DY252_RS11940	COG1538	Outer membrane efflux protein
DY252_RS11950	COG0525	valine-tRNA ligase activity
DY252_RS11960	COG0512	Glutamine amidotransferase of anthranilate synthase
DY252_RS11975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DY252_RS11985	COG0316	Belongs to the HesB IscA family
DY252_RS12000	COG1472	Belongs to the glycosyl hydrolase 3 family
DY252_RS12005	COG1994	Peptidase M50
DY252_RS12010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DY252_RS12015	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DY252_RS12020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DY252_RS12025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DY252_RS12030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DY252_RS12035	COG0805	protein transport
DY252_RS12055	COG4942	peptidase
DY252_RS12065	COG1862	Preprotein translocase
DY252_RS12080	COG3737	Protein of unknown function (DUF498/DUF598)
DY252_RS12085	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DY252_RS12090	COG0668	transmembrane transport
DY252_RS12115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DY252_RS12120	COG0191	fructose-bisphosphate aldolase activity
DY252_RS12125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DY252_RS12135	COG1175	transmembrane transport
DY252_RS12140	COG0395	ABC-type sugar transport system, permease component
DY252_RS12150	COG1956	GAF domain-containing protein
DY252_RS12155	COG0629	single-stranded DNA binding
DY252_RS12190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DY252_RS12200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DY252_RS12210	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DY252_RS12215	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DY252_RS12260	COG2824	Alkylphosphonate utilization operon protein PhnA
DY252_RS12270	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DY252_RS12275	COG2951	lytic endotransglycosylase activity
DY252_RS12285	COG1686	Belongs to the peptidase S11 family
DY252_RS12290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DY252_RS12305	COG0084	hydrolase, TatD family'
DY252_RS12310	COG0321	lipoyl(octanoyl) transferase activity
DY252_RS12310	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DY252_RS12335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DY252_RS12340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DY252_RS12385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DY252_RS12395	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS12400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DY252_RS12410	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_RS12415	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_RS12420	COG1129	ABC transporter
DY252_RS12430	COG4585	Histidine kinase
DY252_RS12440	COG0642	Histidine kinase
DY252_RS12460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DY252_RS12490	COG3180	Ammonia monooxygenase
DY252_RS12495	COG0446	pyridine nucleotide-disulphide oxidoreductase
DY252_RS12510	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DY252_RS12545	COG0785	Cytochrome C biogenesis protein
DY252_RS12560	COG2391	methyltransferase activity
DY252_RS12580	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DY252_RS12585	COG1917	Cupin 2, conserved barrel domain protein
DY252_RS12590	COG0527	aspartate kinase activity
DY252_RS12595	COG3956	TIGRFAM MazG family protein
DY252_RS12600	COG0483	inositol monophosphate 1-phosphatase activity
DY252_RS12605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DY252_RS12620	COG0569	domain protein
DY252_RS12625	COG2204	response regulator
DY252_RS12665	COG1324	tolerance protein
DY252_RS12690	COG0776	regulation of translation
DY252_RS12695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DY252_RS12700	COG0416	fatty acid biosynthetic process
DY252_RS12720	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DY252_RS12725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DY252_RS12730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DY252_RS12735	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DY252_RS12735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DY252_RS12745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DY252_RS12745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DY252_RS12750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DY252_RS12755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DY252_RS12760	COG0698	ribose 5-phosphate isomerase
DY252_RS12770	COG0683	leucine binding
DY252_RS12810	COG1024	Enoyl-CoA hydratase
DY252_RS12815	COG1960	acyl-CoA dehydrogenase activity
DY252_RS12825	COG1349	DNA-binding transcription factor activity
DY252_RS12835	COG0113	porphobilinogen synthase activity
DY252_RS12840	COG1011	Hydrolase
DY252_RS12850	COG0318	PFAM AMP-dependent synthetase and ligase
DY252_RS12860	COG1012	belongs to the aldehyde dehydrogenase family
DY252_RS12865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DY252_RS12870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DY252_RS12875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DY252_RS12880	COG1360	Flagellar Motor Protein
DY252_RS12890	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_RS12895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_RS12905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DY252_RS12910	COG1381	Involved in DNA repair and RecF pathway recombination
DY252_RS12930	COG0681	Belongs to the peptidase S26 family
DY252_RS12935	COG0736	holo-[acyl-carrier-protein] synthase activity
DY252_RS12940	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DY252_RS12970	COG1573	uracil-dna glycosylase
DY252_RS12975	COG0514	ATP-dependent DNA helicase (RecQ)
DY252_RS12980	COG0386	Belongs to the glutathione peroxidase family
DY252_RS12985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DY252_RS12990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DY252_RS12995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DY252_RS13000	COG0741	lytic transglycosylase activity
DY252_RS13000	COG0739	heme binding
DY252_RS13000	COG1196	nuclear chromosome segregation
DY252_RS13015	COG0739	heme binding
DY252_RS13020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DY252_RS13025	COG1546	Belongs to the CinA family
DY252_RS13025	COG1058	Belongs to the CinA family
DY252_RS13030	COG2867	negative regulation of translational initiation
DY252_RS13035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DY252_RS13040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DY252_RS13045	COG0508	dehydrogenase complex catalyzes the overall conversion of
DY252_RS13050	COG0508	dehydrogenase complex catalyzes the overall conversion of
DY252_RS13050	COG0022	dehydrogenase e1 component
DY252_RS13055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DY252_RS13065	COG0148	phosphopyruvate hydratase activity
DY252_RS13085	COG0149	triose-phosphate isomerase activity
DY252_RS13090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DY252_RS13095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DY252_RS13100	COG2861	carbohydrate metabolic process
DY252_RS13120	COG0315	cyclic pyranopterin monophosphate synthase activity
DY252_RS13130	COG2333	competence protein COMEC
DY252_RS13130	COG0658	competence protein
DY252_RS13135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DY252_RS13140	COG0372	Belongs to the citrate synthase family
DY252_RS13150	COG1280	lysine exporter protein (LysE YggA)
DY252_RS13155	COG0583	DNA-binding transcription factor activity
DY252_RS13165	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DY252_RS13170	COG3494	Protein of unknown function (DUF1009)
DY252_RS13175	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DY252_RS13200	COG0750	zinc metalloprotease
DY252_RS13205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DY252_RS13215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DY252_RS13230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DY252_RS13235	COG0052	Belongs to the universal ribosomal protein uS2 family
DY252_RS13255	COG0442	prolyl-tRNA aminoacylation
DY252_RS13270	COG0346	lactoylglutathione lyase activity
DY252_RS13305	COG0713	ATP synthesis coupled electron transport
DY252_RS13315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DY252_RS13320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DY252_RS13325	COG1034	ATP synthesis coupled electron transport
DY252_RS13330	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DY252_RS13335	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DY252_RS13350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DY252_RS13355	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DY252_RS13365	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DY252_RS13385	COG0776	regulation of translation
DY252_RS13400	COG0740	serine-type endopeptidase activity
DY252_RS13420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DY252_RS13420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DY252_RS13430	COG2205	protein histidine kinase activity
DY252_RS13430	COG2202	Pas domain
DY252_RS13445	COG2217	Heavy metal translocating P-type atpase
DY252_RS13450	COG2193	ferroxidase activity
DY252_RS13460	COG3046	protein related to deoxyribodipyrimidine photolyase
DY252_RS13465	COG0415	Belongs to the DNA photolyase family
DY252_RS13490	COG1175	transmembrane transport
DY252_RS13495	COG0395	ABC-type sugar transport system, permease component
DY252_RS13500	COG3842	ATPase activity
DY252_RS13510	COG0745	RESPONSE REGULATOR receiver
DY252_RS13520	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DY252_RS13555	COG0010	Belongs to the arginase family
DY252_RS13560	COG1012	belongs to the aldehyde dehydrogenase family
DY252_RS13565	COG1917	Cupin 2, conserved barrel domain protein
DY252_RS13565	COG1396	sequence-specific DNA binding
DY252_RS13570	COG0174	glutamine synthetase
DY252_RS13595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_RS13610	COG1012	belongs to the aldehyde dehydrogenase family
DY252_RS13625	COG4176	ABC-type proline glycine betaine transport system permease component
DY252_RS13630	COG0517	IMP dehydrogenase activity
DY252_RS13630	COG4175	Glycine betaine
DY252_RS13640	COG0583	DNA-binding transcription factor activity
DY252_RS13650	COG1177	transmembrane transport
DY252_RS13660	COG3842	ATPase activity
DY252_RS13665	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DY252_RS13670	COG3246	L-lysine catabolic process to acetate
DY252_RS13685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DY252_RS13690	COG0251	oxidation-reduction process
DY252_RS13710	COG2423	ornithine cyclodeaminase activity
DY252_RS13725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_RS13730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_RS13740	COG1737	Transcriptional regulator
DY252_RS13750	COG0729	surface antigen
DY252_RS13800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DY252_RS13805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DY252_RS13810	COG3485	protocatechuate 3,4-dioxygenase
DY252_RS13815	COG3485	protocatechuate 3,4-dioxygenase
DY252_RS13825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DY252_RS13830	COG0583	DNA-binding transcription factor activity
DY252_RS13845	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_RS13855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DY252_RS13860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_RS13860	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DY252_RS13875	COG2264	protein methyltransferase activity
DY252_RS13885	COG2814	Major facilitator Superfamily
DY252_RS13895	COG2375	cellular response to nickel ion
DY252_RS13950	COG3769	mannosylglycerate metabolic process
DY252_RS13955	COG1215	transferase activity, transferring glycosyl groups
DY252_RS13970	COG0366	Alpha amylase catalytic
DY252_RS13985	COG1247	-acetyltransferase
DY252_RS14035	COG2186	Transcriptional regulator
DY252_RS14040	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_RS14045	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_RS14050	COG1129	ABC transporter
DY252_RS14055	COG1879	ABC-type sugar transport system periplasmic component
DY252_RS14070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_RS14080	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_RS14085	COG1802	Transcriptional regulator
DY252_RS14155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DY252_RS14170	COG0308	aminopeptidase N
DY252_RS14190	COG1280	lysine exporter protein (LysE YggA)
DY252_RS14210	COG2205	protein histidine kinase activity
DY252_RS14220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_RS14225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_RS14245	COG1629	transport
DY252_RS14250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DY252_RS14265	COG0848	biopolymer transport protein
DY252_RS14275	COG0811	peptide transport
DY252_RS14295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DY252_RS14300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DY252_RS14330	COG0418	dihydroorotase activity
DY252_RS14365	COG0583	DNA-binding transcription factor activity
DY252_RS14375	COG0436	Aminotransferase
DY252_RS14390	COG0457	Tetratricopeptide repeat
DY252_RS14395	COG5001	Diguanylate cyclase
DY252_RS14395	COG5002	protein histidine kinase activity
DY252_RS14395	COG3447	MASE1 domain protein
DY252_RS14405	COG1765	OsmC-like protein
DY252_RS14420	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DY252_RS14425	COG0457	Tetratricopeptide repeat
DY252_RS14440	COG5001	Diguanylate cyclase
DY252_RS14440	COG3300	MHYT domain
DY252_RS14455	COG1802	Transcriptional regulator
DY252_RS14460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_RS14470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_RS14490	COG0583	DNA-binding transcription factor activity
DY252_RS14515	COG4177	L-phenylalanine transmembrane transporter activity
DY252_RS14570	COG0482	sulfurtransferase activity
DY252_RS14575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DY252_RS14580	COG2975	iron-sulfur cluster assembly
DY252_RS14585	COG0633	Ferredoxin
DY252_RS14595	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DY252_RS14600	COG0316	Belongs to the HesB IscA family
DY252_RS14605	COG0822	iron-sulfur transferase activity
DY252_RS14615	COG1104	cysteine desulfurase activity
DY252_RS14620	COG1959	2 iron, 2 sulfur cluster binding
DY252_RS14625	COG1045	serine acetyltransferase
DY252_RS14630	COG2945	thiolester hydrolase activity
DY252_RS14635	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DY252_RS14650	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DY252_RS14655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DY252_RS14665	COG2833	Protein of unknown function (DUF455)
DY252_RS14685	COG2972	Histidine kinase
DY252_RS14685	COG0840	transmembrane signaling receptor activity
DY252_RS14710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DY252_RS14715	COG0860	N-Acetylmuramoyl-L-alanine amidase
DY252_RS14720	COG1530	ribonuclease E activity
DY252_RS14745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DY252_RS14745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DY252_RS14755	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DY252_RS14760	COG0511	ligase activity, forming carbon-carbon bonds
DY252_RS14765	COG0439	Biotin carboxylase
DY252_RS14770	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DY252_RS14780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DY252_RS14810	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DY252_RS14825	COG1686	Belongs to the peptidase S11 family
DY252_RS14835	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DY252_RS14840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DY252_RS14845	COG0484	heat shock protein binding
DY252_RS14865	COG0579	oxidoreductase
DY252_RS14870	COG2342	PFAM TM1410 hypothetical-related protein
DY252_RS14880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DY252_RS14885	COG0028	Belongs to the TPP enzyme family
DY252_RS14930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DY252_RS14935	COG1024	Enoyl-CoA hydratase
DY252_RS14940	COG4770	biotin carboxylase activity
DY252_RS14965	COG0840	transmembrane signaling receptor activity
DY252_RS14975	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DY252_RS15005	COG2084	Dehydrogenase
DY252_RS15010	COG0793	Belongs to the peptidase S41A family
DY252_RS15015	COG1960	acyl-CoA dehydrogenase activity
DY252_RS15020	COG0795	lipopolysaccharide-transporting ATPase activity
DY252_RS15030	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DY252_RS15035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DY252_RS15040	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DY252_RS15045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DY252_RS15050	COG0194	GDP metabolic process
DY252_RS15055	COG1561	YicC-like family, N-terminal region
DY252_RS15060	COG0300	oxidoreductase activity
DY252_RS15065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DY252_RS15070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DY252_RS15085	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DY252_RS15095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DY252_RS15110	COG0305	Participates in initiation and elongation during chromosome replication
DY252_RS15115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DY252_RS15120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DY252_RS15125	COG1127	ABC transporter
DY252_RS15140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DY252_RS15145	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS15180	COG1160	GTP binding
DY252_RS15245	COG2132	Multicopper oxidase
DY252_RS15300	COG0789	Transcriptional regulator
DY252_RS15310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DY252_RS15325	COG1902	pentaerythritol trinitrate reductase activity
DY252_RS15335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DY252_RS15345	COG0789	Transcriptional regulator
DY252_RS15370	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DY252_RS15375	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DY252_RS15380	COG1091	dTDP-4-dehydrorhamnose reductase activity
DY252_RS15395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DY252_RS15400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DY252_RS15405	COG0546	phosphoglycolate phosphatase activity
DY252_RS15410	COG0129	dihydroxy-acid dehydratase activity
DY252_RS15415	COG4214	carbohydrate transport
DY252_RS15425	COG4213	ABC transporter substrate-binding protein
DY252_RS15440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DY252_RS15465	COG1234	tRNA 3'-trailer cleavage
DY252_RS15480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DY252_RS15565	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DY252_RS15570	COG2205	protein histidine kinase activity
DY252_RS15575	COG0745	RESPONSE REGULATOR receiver
DY252_RS15590	COG1283	sodium-dependent phosphate transmembrane transporter activity
DY252_RS15595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DY252_RS15600	COG0367	asparagine synthase
DY252_RS15605	COG3284	Transcriptional regulator
DY252_RS15610	COG1012	belongs to the aldehyde dehydrogenase family
DY252_RS15620	COG2855	membrane
DY252_RS15625	COG0583	DNA-binding transcription factor activity
DY252_RS15630	COG1271	oxidase subunit
DY252_RS15635	COG1294	oxidase, subunit
DY252_RS15645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DY252_RS15655	COG0175	sulfate reduction
DY252_RS15675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DY252_RS15690	COG2827	Endonuclease containing a URI domain
DY252_RS15695	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS15705	COG0800	Aldolase
DY252_RS15710	COG3734	2-keto-3-deoxy-galactonokinase
DY252_RS15720	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DY252_RS15740	COG1431	PFAM Stem cell self-renewal protein Piwi
DY252_RS15795	COG3938	Belongs to the proline racemase family
DY252_RS15810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_RS15815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DY252_RS15830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DY252_RS15850	COG2814	Major facilitator Superfamily
DY252_RS15875	COG3842	ATPase activity
DY252_RS15890	COG0395	ABC-type sugar transport system, permease component
DY252_RS15910	COG0746	molybdenum cofactor guanylyltransferase activity
DY252_RS15920	COG0583	DNA-binding transcription factor activity
DY252_RS15925	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS15945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DY252_RS15950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DY252_RS15970	COG1309	transcriptional regulator
DY252_RS15990	COG0493	'glutamate synthase
DY252_RS15995	COG1607	acyl-coa hydrolase
DY252_RS16000	COG1363	Peptidase, m42
DY252_RS16010	COG4608	Belongs to the ABC transporter superfamily
DY252_RS16015	COG0444	Belongs to the ABC transporter superfamily
DY252_RS16025	COG0747	negative chemotaxis
DY252_RS16045	COG1115	amino acid carrier protein
DY252_RS16065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DY252_RS16085	COG3386	PFAM SMP-30 Gluconolaconase
DY252_RS16090	COG1120	ATPase activity
DY252_RS16100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DY252_RS16105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DY252_RS16135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DY252_RS16150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_RS16155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DY252_RS16165	COG3386	PFAM SMP-30 Gluconolaconase
DY252_RS16170	COG2186	Transcriptional regulator
DY252_RS16175	COG2017	converts alpha-aldose to the beta-anomer
DY252_RS16180	COG2186	Transcriptional regulator
DY252_RS16185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DY252_RS16190	COG1069	ribulokinase activity
DY252_RS16195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DY252_RS16200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DY252_RS16225	COG1595	DNA-templated transcription, initiation
DY252_RS16245	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DY252_RS16260	COG0583	DNA-binding transcription factor activity
DY252_RS16265	COG0697	spore germination
DY252_RS16300	COG0167	dihydroorotate dehydrogenase activity
DY252_RS16305	COG1902	pentaerythritol trinitrate reductase activity
DY252_RS16335	COG0384	phenazine biosynthesis protein PhzF
DY252_RS16345	COG3550	peptidyl-serine autophosphorylation
DY252_RS16365	COG3311	Transcriptional regulator
DY252_RS16505	COG0483	inositol monophosphate 1-phosphatase activity
DY252_RS16510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DY252_RS16530	COG0506	proline dehydrogenase activity
DY252_RS16540	COG3852	Histidine kinase
DY252_RS16565	COG1846	Transcriptional regulator
DY252_RS16575	COG1764	response to oxidative stress
DY252_RS16590	COG1238	metal cluster binding
DY252_RS16605	COG2207	Transcriptional regulator
DY252_RS16605	COG1917	Cupin 2, conserved barrel domain protein
DY252_RS16610	COG1199	ATP-dependent helicase activity
DY252_RS16615	COG1819	glycosyl
DY252_RS16630	COG2217	Heavy metal translocating P-type atpase
DY252_RS16635	COG3247	response to pH
DY252_RS16640	COG0583	DNA-binding transcription factor activity
DY252_RS16660	COG5001	Diguanylate cyclase
DY252_RS16670	COG2084	Dehydrogenase
DY252_RS16695	COG0583	DNA-binding transcription factor activity
DY252_RS16700	COG2271	Major facilitator Superfamily
DY252_RS16715	COG0583	DNA-binding transcription factor activity
DY252_RS16720	COG1643	Atp-dependent helicase
DY252_RS16790	COG0438	transferase activity, transferring glycosyl groups
DY252_RS16810	COG0495	leucyl-tRNA aminoacylation
DY252_RS16840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DY252_RS16845	COG2226	methyltransferase
DY252_RS16855	COG0720	synthase
DY252_RS16860	COG0602	queuosine metabolic process
DY252_RS16910	COG0688	phosphatidylethanolamine metabolic process
DY252_RS16935	COG3634	alkyl hydroperoxide reductase activity
DY252_RS16940	COG1349	DNA-binding transcription factor activity
DY252_RS16960	COG0395	ABC-type sugar transport system, permease component
DY252_RS16965	COG0583	DNA-binding transcription factor activity
DY252_RS16990	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DY252_RS17015	COG0384	phenazine biosynthesis protein PhzF
DY252_RS17035	COG0538	isocitrate dehydrogenase activity
DY252_RS17090	COG0655	NAD(P)H dehydrogenase (quinone) activity
DY252_RS17095	COG0584	glycerophosphoryl diester phosphodiesterase
DY252_RS17105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DY252_RS17110	COG2207	Transcriptional regulator
DY252_RS17110	COG1609	Transcriptional regulator
DY252_RS17115	COG1309	transcriptional regulator
DY252_RS17125	COG1176	ABC-type spermidine putrescine transport system, permease component I
DY252_RS17130	COG1177	transmembrane transport
DY252_RS17135	COG3842	ATPase activity
DY252_RS17185	COG5487	UPF0391 membrane protein
DY252_RS17205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DY252_RS17270	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DY252_RS17280	COG1987	bacterial-type flagellum assembly
DY252_RS17285	COG1677	Flagellar hook-basal body complex protein FliE
DY252_RS17290	COG1558	bacterial-type flagellum-dependent cell motility
DY252_RS17295	COG1815	bacterial-type flagellum-dependent cell motility
DY252_RS17305	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DY252_RS17320	COG1338	Plays a role in the flagellum-specific transport system
DY252_RS17325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DY252_RS17355	COG0745	RESPONSE REGULATOR receiver
DY252_RS17380	COG4786	Flagellar basal body rod
DY252_RS17385	COG4786	Flagellar basal body rod
DY252_RS17395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DY252_RS17415	COG1706	bacterial-type flagellum-dependent cell motility
DY252_RS17420	COG3951	Flagellar rod assembly protein muramidase FlgJ
DY252_RS17435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DY252_RS17450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DY252_RS17455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DY252_RS17460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DY252_RS17480	COG1516	flagellar protein fliS
DY252_RS17495	COG1749	Flagellar hook protein flgE
DY252_RS17500	COG1766	The M ring may be actively involved in energy transduction
DY252_RS17510	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DY252_RS17515	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DY252_RS17520	COG2204	response regulator
DY252_RS17525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DY252_RS17550	COG3128	pkhd-type hydroxylase
DY252_RS17555	COG4136	ATPase activity
DY252_RS17560	COG4135	transport system, permease component
DY252_RS17565	COG4134	Bacterial extracellular solute-binding protein
DY252_RS17570	COG0861	Integral membrane protein TerC family
DY252_RS17595	COG0745	RESPONSE REGULATOR receiver
DY252_RS17615	COG0784	Response regulator, receiver
DY252_RS17615	COG2198	Histidine kinase
DY252_RS17615	COG0643	Histidine kinase
DY252_RS17625	COG2198	Histidine kinase
DY252_RS17625	COG0784	Response regulator, receiver
DY252_RS17625	COG0643	Histidine kinase
DY252_RS17670	COG2962	Rard protein
DY252_RS17675	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DY252_RS17680	COG0668	transmembrane transport
DY252_RS17690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DY252_RS17705	COG0300	oxidoreductase activity
DY252_RS17710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DY252_RS17730	COG0477	Major facilitator Superfamily
DY252_RS17745	COG0789	Transcriptional regulator
DY252_RS17760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DY252_RS17770	COG0393	Putative heavy-metal-binding
DY252_RS17775	COG0393	Putative heavy-metal-binding
DY252_RS17790	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DY252_RS17805	COG1739	Uncharacterized protein family UPF0029
DY252_RS17810	COG1609	Transcriptional regulator
DY252_RS17815	COG3265	gluconokinase activity
DY252_RS17820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_RS17855	COG0175	sulfate reduction
DY252_RS17865	COG1612	heme a metabolic process
DY252_RS17875	COG0312	modulator of DNA gyrase
DY252_RS17905	COG0747	negative chemotaxis
DY252_RS17910	COG0601	transmembrane transport
DY252_RS17915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DY252_RS17920	COG0444	Belongs to the ABC transporter superfamily
DY252_RS17925	COG4608	Belongs to the ABC transporter superfamily
DY252_RS17930	COG1280	lysine exporter protein (LysE YggA)
DY252_RS17955	COG1349	DNA-binding transcription factor activity
DY252_RS17970	COG3639	organic phosphonate transmembrane transporter activity
DY252_RS17995	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DY252_RS18000	COG2264	protein methyltransferase activity
DY252_RS18035	COG0312	modulator of DNA gyrase
DY252_RS18045	COG1597	lipid kinase activity
DY252_RS18055	COG0438	transferase activity, transferring glycosyl groups
DY252_RS18065	COG1132	(ABC) transporter
DY252_RS18075	COG1519	Transferase
DY252_RS18080	COG1663	tetraacyldisaccharide 4'-kinase activity
DY252_RS18095	COG0405	Gamma-glutamyltransferase
DY252_RS18105	COG1570	exodeoxyribonuclease VII activity
DY252_RS18110	COG0151	Belongs to the GarS family
DY252_RS18115	COG1120	ATPase activity
DY252_RS18120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DY252_RS18130	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DY252_RS18135	COG2207	Transcriptional regulator
DY252_RS18140	COG4221	oxidoreductase activity
DY252_RS18155	COG0590	tRNA wobble adenosine to inosine editing
DY252_RS18160	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DY252_RS18170	COG0742	ribosomal rna small subunit methyltransferase
DY252_RS18195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DY252_RS18225	COG0783	Belongs to the Dps family
DY252_RS18235	COG0552	protein localization to endoplasmic reticulum
DY252_RS18240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DY252_RS18245	COG3706	GGDEF domain
DY252_RS18250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DY252_RS18255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DY252_RS18260	COG0706	membrane insertase activity
DY252_RS18265	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DY252_RS18275	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DY252_RS18295	COG2274	protein secretion by the type I secretion system
DY252_RS18400	COG2239	Acts as a magnesium transporter
DY252_RS18405	COG0281	malic enzyme
DY252_RS18405	COG0280	phosphate acetyltransferase
DY252_RS18420	COG3706	GGDEF domain
DY252_RS18450	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DY252_RS18475	COG2249	NAD(P)H dehydrogenase (quinone) activity
DY252_RS18490	COG1733	regulation of RNA biosynthetic process
DY252_RS18495	COG0456	acetyltransferase
DY252_RS18525	COG1012	belongs to the aldehyde dehydrogenase family
DY252_RS18530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DY252_RS18540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_RS18545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DY252_RS18550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DY252_RS18555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_RS18560	COG3473	Maleate cis-trans isomerase
DY252_RS18565	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DY252_RS18570	COG2423	ornithine cyclodeaminase activity
DY252_RS18575	COG0006	proline dipeptidase activity
DY252_RS18580	COG3608	succinylglutamate desuccinylase aspartoacylase
DY252_RS18585	COG1522	sequence-specific DNA binding
DY252_RS18615	COG0154	amidase activity
DY252_RS18630	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_RS18640	COG0673	inositol 2-dehydrogenase activity
DY252_RS18650	COG1879	ABC-type sugar transport system periplasmic component
DY252_RS18655	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_RS18660	COG1129	ABC transporter
DY252_RS18665	COG1609	Transcriptional regulator
DY252_RS18675	COG0019	diaminopimelate decarboxylase activity
DY252_RS18690	COG1609	Transcriptional regulator
DY252_RS18700	COG1175	transmembrane transport
DY252_RS18705	COG0395	ABC-type sugar transport system, permease component
DY252_RS18750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DY252_RS18755	COG0745	RESPONSE REGULATOR receiver
DY252_RS18760	COG5002	protein histidine kinase activity
DY252_RS18790	COG1802	Transcriptional regulator
DY252_RS18795	COG0405	Gamma-glutamyltransferase
DY252_RS18800	COG0625	glutathione transferase activity
DY252_RS18810	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DY252_RS18825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_RS18850	COG1522	sequence-specific DNA binding
DY252_RS18855	COG0410	ABC transporter
DY252_RS18885	COG0745	RESPONSE REGULATOR receiver
DY252_RS18915	COG0179	Fumarylacetoacetate (FAA) hydrolase
DY252_RS18935	COG0402	S-adenosylhomocysteine deaminase activity
DY252_RS18940	COG1228	amidohydrolase
DY252_RS18945	COG2986	histidine ammonia-lyase
DY252_RS18960	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DY252_RS18970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_RS19000	COG0183	Belongs to the thiolase family
DY252_RS19015	COG1024	Enoyl-CoA hydratase
DY252_RS19020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_RS19050	COG3335	DDE superfamily endonuclease
DY252_RS19080	COG3039	Transposase
DY252_RS19085	COG2204	response regulator
DY252_RS19105	COG3547	Transposase (IS116 IS110 IS902 family)
DY252_RS19110	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_RS19125	COG1960	acyl-CoA dehydrogenase activity
DY252_RS19130	COG1070	Carbohydrate kinase
DY252_RS19135	COG1830	Aldolase
DY252_RS19140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DY252_RS19145	COG0667	Aldo Keto reductase
DY252_RS19150	COG2390	Transcriptional regulator
DY252_RS19155	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_RS19160	COG1129	ABC transporter
DY252_RS19200	COG1129	ABC transporter
DY252_RS19210	COG1454	alcohol dehydrogenase
DY252_RS19215	COG1012	belongs to the aldehyde dehydrogenase family
DY252_RS19220	COG1454	alcohol dehydrogenase
DY252_RS19225	COG0667	Aldo Keto reductase
DY252_RS19235	COG2376	Dihydroxyacetone kinase
DY252_RS19245	COG1129	ABC transporter
DY252_RS19255	COG1172	Belongs to the binding-protein-dependent transport system permease family
DY252_RS19275	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DY252_RS19295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DY252_RS19310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DY252_RS19330	COG0271	Belongs to the BolA IbaG family
DY252_RS19360	COG4536	flavin adenine dinucleotide binding
DY252_RS19365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DY252_RS19380	COG4974	Belongs to the 'phage' integrase family
DY252_RS19385	COG2202	Pas domain
DY252_RS19385	COG2200	EAL domain
DY252_RS19385	COG2199	diguanylate cyclase activity
DY252_RS19420	COG0714	Associated with various cellular activities
DY252_RS19445	COG0435	Glutathione S-transferase
DY252_RS19480	COG1196	nuclear chromosome segregation
DY252_RS19495	COG1194	a g-specific adenine glycosylase
DY252_RS19520	COG4603	Belongs to the binding-protein-dependent transport system permease family
DY252_RS19530	COG0402	S-adenosylhomocysteine deaminase activity
DY252_RS19535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DY252_RS19545	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DY252_RS19570	COG0679	Auxin Efflux Carrier
DY252_RS19575	COG5265	(ABC) transporter
DY252_RS19585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DY252_RS19590	COG0799	negative regulation of ribosome biogenesis
DY252_RS19600	COG0840	transmembrane signaling receptor activity
DY252_RS19605	COG0840	transmembrane signaling receptor activity
DY252_RS19610	COG1349	DNA-binding transcription factor activity
DY252_RS19615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DY252_RS19625	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS19630	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DY252_RS19635	COG1760	l-serine dehydratase
DY252_RS19640	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DY252_RS19645	COG4942	peptidase
DY252_RS19650	COG0793	Belongs to the peptidase S41A family
DY252_RS19660	COG0494	nUDIX hydrolase
DY252_RS19670	COG4106	trans-aconitate 2-methyltransferase activity
DY252_RS19695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DY252_RS19705	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DY252_RS19760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DY252_RS19775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DY252_RS19780	COG0228	four-way junction DNA binding
DY252_RS19810	COG0066	3-isopropylmalate dehydratase activity
DY252_RS19820	COG1595	DNA-templated transcription, initiation
DY252_RS19825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DY252_RS19835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DY252_RS19840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DY252_RS19860	COG0395	ABC-type sugar transport system, permease component
DY252_RS19870	COG1028	Short-chain dehydrogenase reductase Sdr
DY252_RS19880	COG0471	metal ion transport
DY252_RS19880	COG3273	potassium ion transport
DY252_RS19890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DY252_RS19895	COG1872	DUF167
DY252_RS19905	COG0519	Catalyzes the synthesis of GMP from XMP
DY252_RS19910	COG1609	Transcriptional regulator
DY252_RS19925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DY252_RS19990	COG0798	PFAM Bile acid sodium symporter
DY252_RS19995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DY252_RS20005	COG1702	phosphate starvation-inducible protein PhoH
DY252_RS20010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DY252_RS20015	COG1138	Cytochrome C-type biogenesis protein
DY252_RS20020	COG4235	cytochrome complex assembly
DY252_RS20025	COG0784	Response regulator, receiver
DY252_RS20050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DY252_RS20055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DY252_RS20060	COG0625	glutathione transferase activity
DY252_RS20080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DY252_RS20090	COG4974	Belongs to the 'phage' integrase family
DY252_RS20105	COG0625	glutathione transferase activity
DY252_RS20115	COG0174	glutamine synthetase
DY252_RS20125	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DY252_RS20135	COG1051	belongs to the nudix hydrolase family
DY252_RS20140	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DY252_RS20145	COG3264	Mechanosensitive ion channel
DY252_RS20145	COG1196	nuclear chromosome segregation
DY252_RS20155	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DY252_RS20160	COG0039	L-malate dehydrogenase activity
DY252_RS20165	COG0045	succinate-CoA ligase (ADP-forming) activity
DY252_RS20170	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DY252_RS20175	COG0567	Dehydrogenase, E1 component
DY252_RS20180	COG0508	dehydrogenase complex catalyzes the overall conversion of
DY252_RS20190	COG1803	Methylglyoxal synthase
DY252_RS20200	COG0564	pseudouridine synthase activity
DY252_RS20225	COG2211	Major facilitator Superfamily
DY252_RS20230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DY252_RS20240	COG1233	COG1233 Phytoene dehydrogenase and related
DY252_RS20245	COG1595	DNA-templated transcription, initiation
DY252_RS20250	COG3806	Anti-sigma factor
DY252_RS20255	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DY252_RS20260	COG1187	pseudouridine synthase activity
DY252_RS20280	COG3706	GGDEF domain
DY252_RS20290	COG2081	HI0933 family
DY252_RS20300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_RS20320	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DY252_RS20325	COG0024	Methionine aminopeptidase
DY252_RS20335	COG3485	protocatechuate 3,4-dioxygenase
DY252_RS20340	COG3485	protocatechuate 3,4-dioxygenase
DY252_RS20345	COG0583	DNA-binding transcription factor activity
DY252_RS20355	COG2188	Transcriptional regulator
DY252_RS20360	COG3624	Phosphonate C-P lyase system protein PhnG
DY252_RS20370	COG3626	phosphonate metabolism
DY252_RS20375	COG3627	carbon phosphorus lyase activity
DY252_RS20380	COG4107	phosphonate C-P lyase system protein PhnK
DY252_RS20385	COG4778	phosphonate C-P lyase system protein PhnL
DY252_RS20390	COG3454	Phosphonate metabolism
DY252_RS20395	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DY252_RS20395	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
DY252_RS20400	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
DY252_RS20410	COG3639	organic phosphonate transmembrane transporter activity
DY252_RS20415	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DY252_RS20420	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DY252_RS20425	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DY252_RS20435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DY252_RS20455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DY252_RS20475	COG0824	Thioesterase
DY252_RS20475	COG1250	3-hydroxyacyl-CoA dehydrogenase
DY252_RS20480	COG3246	L-lysine catabolic process to acetate
DY252_RS20490	COG0039	L-malate dehydrogenase activity
DY252_RS20495	COG4638	Rieske (2fe-2S)
DY252_RS20500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DY252_RS20510	COG2086	electron transfer activity
DY252_RS20520	COG0788	formyltetrahydrofolate deformylase activity
DY252_RS20530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DY252_RS20540	COG2205	protein histidine kinase activity
DY252_RS20540	COG0784	Response regulator, receiver
DY252_RS20565	COG0666	response to abiotic stimulus
DY252_RS20610	COG3547	Transposase (IS116 IS110 IS902 family)
DY252_RS20640	COG3328	transposase activity
DY252_RS20645	COG2217	Heavy metal translocating P-type atpase
DY252_RS20650	COG0640	Transcriptional regulator
DY252_RS20680	COG0789	Transcriptional regulator
DY252_RS20685	COG2814	Major facilitator Superfamily
DY252_RS20690	COG1937	Protein conserved in bacteria
DY252_RS20695	COG0678	peroxiredoxin activity
DY252_RS20695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DY252_RS20705	COG0640	Transcriptional regulator
DY252_RS20710	COG3328	transposase activity
DY252_RS20715	COG1230	cation diffusion facilitator family transporter
DY252_RS20725	COG0583	DNA-binding transcription factor activity
DY252_RS20735	COG2948	multi-organism process
DY252_RS20750	COG3846	protein secretion by the type IV secretion system
DY252_RS20765	COG3451	type IV secretory pathway VirB4
DY252_RS20780	COG4962	Type ii secretion system protein e
DY252_RS20830	COG2963	transposase activity
DY252_RS20865	COG0741	lytic transglycosylase activity
DY252_RS20890	COG1192	Involved in chromosome partitioning
DY252_RS20920	COG5489	Protein of unknown function (DUF736)
DY252_RS20950	COG0667	Aldo Keto reductase
DY252_RS20990	COG0464	growth
DY252_RS21010	COG1309	transcriptional regulator
DY252_RS21085	COG0582	viral genome integration into host DNA
DY252_RS21105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DY252_RS21155	COG5489	Protein of unknown function (DUF736)
DY252_RS21210	COG3550	peptidyl-serine autophosphorylation
DY252_RS21215	COG3620	sequence-specific DNA binding
DY252_RS21225	COG4227	nucleotidyltransferase activity
DY252_RS21275	COG0584	glycerophosphoryl diester phosphodiesterase
DY252_RS21280	COG0534	Mate efflux family protein
DY252_RS21295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DY252_RS21300	COG3001	Fructosamine kinase
DY252_RS21310	COG0302	gtp cyclohydrolase
DY252_RS21335	COG3852	Histidine kinase
DY252_RS21340	COG2818	Glycosylase
DY252_RS21350	COG1309	transcriptional regulator
DY252_RS21355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DY252_RS21365	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DY252_RS21375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DY252_RS21380	COG1525	nuclease
DY252_RS21405	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DY252_RS21425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DY252_RS21440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DY252_RS21445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DY252_RS21445	COG0512	Glutamine amidotransferase of anthranilate synthase
DY252_RS21455	COG3237	CsbD-like
DY252_RS21470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DY252_RS21480	COG5001	Diguanylate cyclase
DY252_RS21490	COG2171	N-acyltransferase activity
DY252_RS21495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DY252_RS21515	COG0583	DNA-binding transcription factor activity
DY252_RS21530	COG2816	NAD+ diphosphatase activity
DY252_RS21540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DY252_RS21545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DY252_RS21550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DY252_RS21555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DY252_RS21565	COG1802	Transcriptional regulator
DY252_RS21570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DY252_RS21575	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DY252_RS21585	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DY252_RS21625	COG2205	protein histidine kinase activity
DY252_RS21630	COG1078	dGTPase activity
DY252_RS21650	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DY252_RS21655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DY252_RS21660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DY252_RS21665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DY252_RS21665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DY252_RS21670	COG1660	Displays ATPase and GTPase activities
DY252_RS21675	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DY252_RS21680	COG2205	protein histidine kinase activity
DY252_RS21685	COG0745	RESPONSE REGULATOR receiver
DY252_RS21690	COG4191	Histidine kinase
DY252_RS21695	COG2204	response regulator
DY252_RS21700	COG2358	TRAP transporter, solute receptor (TAXI family
DY252_RS21730	COG0583	DNA-binding transcription factor activity
DY252_RS21740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DY252_RS21750	COG0242	peptide deformylase activity
DY252_RS21755	COG1322	Protein conserved in bacteria
DY252_RS21760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DY252_RS21765	COG0583	DNA-binding transcription factor activity
DY252_RS21770	COG3181	Tripartite tricarboxylate transporter family receptor
DY252_RS21790	COG0473	3-isopropylmalate dehydrogenase activity
DY252_RS21795	COG0583	DNA-binding transcription factor activity
DY252_RS21820	COG0659	secondary active sulfate transmembrane transporter activity
DY252_RS21825	COG0589	response to stress
DY252_RS21845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DY252_RS21850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DY252_RS21855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DY252_RS21860	COG0842	Transport permease protein
DY252_RS21865	COG2137	regulation of response to DNA damage stimulus
DY252_RS21870	COG1393	Belongs to the ArsC family
DY252_RS21885	COG1346	cytolysis
DY252_RS21910	COG0137	argininosuccinate synthase activity
DY252_RS21920	COG1280	lysine exporter protein (LysE YggA)
DY252_RS21925	COG0583	DNA-binding transcription factor activity
DY252_RS21960	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DY252_RS22160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA