locus-tag	class	description
CSC3H3_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CSC3H3_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CSC3H3_RS00025	COG0028	Belongs to the TPP enzyme family
CSC3H3_RS00030	COG1802	Transcriptional regulator
CSC3H3_RS00035	COG2084	Dehydrogenase
CSC3H3_RS00040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSC3H3_RS00045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS00050	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CSC3H3_RS00060	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CSC3H3_RS00065	COG4221	oxidoreductase activity
CSC3H3_RS00070	COG4977	sequence-specific DNA binding
CSC3H3_RS00090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CSC3H3_RS00095	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CSC3H3_RS00120	COG0583	DNA-binding transcription factor activity
CSC3H3_RS00125	COG1280	lysine exporter protein (LysE YggA)
CSC3H3_RS00135	COG0137	argininosuccinate synthase activity
CSC3H3_RS00150	COG0330	HflC and HflK could
CSC3H3_RS00160	COG1346	cytolysis
CSC3H3_RS00175	COG1393	Belongs to the ArsC family
CSC3H3_RS00180	COG2137	regulation of response to DNA damage stimulus
CSC3H3_RS00185	COG0842	Transport permease protein
CSC3H3_RS00190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CSC3H3_RS00195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CSC3H3_RS00200	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CSC3H3_RS00220	COG1595	DNA-templated transcription, initiation
CSC3H3_RS00230	COG0589	response to stress
CSC3H3_RS00235	COG0659	secondary active sulfate transmembrane transporter activity
CSC3H3_RS00240	COG0840	transmembrane signaling receptor activity
CSC3H3_RS00245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CSC3H3_RS00260	COG0242	peptide deformylase activity
CSC3H3_RS00305	COG2358	TRAP transporter, solute receptor (TAXI family
CSC3H3_RS00310	COG0745	RESPONSE REGULATOR receiver
CSC3H3_RS00315	COG2205	protein histidine kinase activity
CSC3H3_RS00320	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CSC3H3_RS00330	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CSC3H3_RS00330	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CSC3H3_RS00340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CSC3H3_RS00345	COG3667	copper resistance
CSC3H3_RS00350	COG2132	Multicopper oxidase
CSC3H3_RS00365	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CSC3H3_RS00385	COG0583	DNA-binding transcription factor activity
CSC3H3_RS00410	COG0519	Catalyzes the synthesis of GMP from XMP
CSC3H3_RS00425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CSC3H3_RS00430	COG0569	domain protein
CSC3H3_RS00435	COG1078	dGTPase activity
CSC3H3_RS00440	COG2205	protein histidine kinase activity
CSC3H3_RS00475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CSC3H3_RS00480	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CSC3H3_RS00485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CSC3H3_RS00505	COG2816	NAD+ diphosphatase activity
CSC3H3_RS00540	COG0583	DNA-binding transcription factor activity
CSC3H3_RS00555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CSC3H3_RS00560	COG2171	N-acyltransferase activity
CSC3H3_RS00570	COG2203	Gaf domain
CSC3H3_RS00570	COG5001	Diguanylate cyclase
CSC3H3_RS00570	COG4251	negative regulation of phosphorylation
CSC3H3_RS00570	COG3706	GGDEF domain
CSC3H3_RS00575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CSC3H3_RS00580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CSC3H3_RS00635	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CSC3H3_RS00645	COG5001	Diguanylate cyclase
CSC3H3_RS00645	COG3300	MHYT domain
CSC3H3_RS00650	COG4191	Histidine kinase
CSC3H3_RS00650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CSC3H3_RS00670	COG0512	Glutamine amidotransferase of anthranilate synthase
CSC3H3_RS00670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CSC3H3_RS00675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CSC3H3_RS00690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CSC3H3_RS00700	COG0840	transmembrane signaling receptor activity
CSC3H3_RS00725	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CSC3H3_RS00750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CSC3H3_RS00760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CSC3H3_RS00780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CSC3H3_RS00785	COG5002	protein histidine kinase activity
CSC3H3_RS00795	COG0398	Pfam SNARE associated Golgi protein
CSC3H3_RS00810	COG0302	gtp cyclohydrolase
CSC3H3_RS00815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CSC3H3_RS00825	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CSC3H3_RS00830	COG0390	transport system, permease component
CSC3H3_RS00840	COG0662	Cupin 2, conserved barrel domain protein
CSC3H3_RS00845	COG0534	Mate efflux family protein
CSC3H3_RS00850	COG0584	glycerophosphoryl diester phosphodiesterase
CSC3H3_RS00885	COG1971	Probably functions as a manganese efflux pump
CSC3H3_RS00905	COG1396	sequence-specific DNA binding
CSC3H3_RS00945	COG1522	sequence-specific DNA binding
CSC3H3_RS00960	COG0628	permease
CSC3H3_RS00980	COG2205	protein histidine kinase activity
CSC3H3_RS00980	COG5002	protein histidine kinase activity
CSC3H3_RS00980	COG0784	Response regulator, receiver
CSC3H3_RS00985	COG3706	GGDEF domain
CSC3H3_RS00985	COG4251	negative regulation of phosphorylation
CSC3H3_RS00985	COG5001	Diguanylate cyclase
CSC3H3_RS00985	COG2203	Gaf domain
CSC3H3_RS00990	COG0745	RESPONSE REGULATOR receiver
CSC3H3_RS01055	COG3383	formate dehydrogenase (NAD+) activity
CSC3H3_RS01065	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CSC3H3_RS01070	COG0583	DNA-binding transcription factor activity
CSC3H3_RS01075	COG2223	nitrite transmembrane transporter activity
CSC3H3_RS01085	COG4191	Histidine kinase
CSC3H3_RS01090	COG2204	response regulator
CSC3H3_RS01100	COG0243	molybdopterin cofactor binding
CSC3H3_RS01150	COG2828	Protein conserved in bacteria
CSC3H3_RS01170	COG0583	DNA-binding transcription factor activity
CSC3H3_RS01190	COG0668	transmembrane transport
CSC3H3_RS01200	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CSC3H3_RS01210	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CSC3H3_RS01215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CSC3H3_RS01215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CSC3H3_RS01265	COG0420	3'-5' exonuclease activity
CSC3H3_RS01285	COG4372	Transposase
CSC3H3_RS01335	COG4962	Type ii secretion system protein e
CSC3H3_RS01440	COG0024	Methionine aminopeptidase
CSC3H3_RS01445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CSC3H3_RS01460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS01470	COG2081	HI0933 family
CSC3H3_RS01500	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CSC3H3_RS01505	COG3806	Anti-sigma factor
CSC3H3_RS01510	COG1595	DNA-templated transcription, initiation
CSC3H3_RS01525	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CSC3H3_RS01555	COG0564	pseudouridine synthase activity
CSC3H3_RS01565	COG1803	Methylglyoxal synthase
CSC3H3_RS01570	COG0583	DNA-binding transcription factor activity
CSC3H3_RS01575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSC3H3_RS01620	COG0508	dehydrogenase complex catalyzes the overall conversion of
CSC3H3_RS01630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CSC3H3_RS01635	COG0045	succinate-CoA ligase (ADP-forming) activity
CSC3H3_RS01640	COG0039	L-malate dehydrogenase activity
CSC3H3_RS01650	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CSC3H3_RS01665	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CSC3H3_RS01665	COG3264	Mechanosensitive ion channel
CSC3H3_RS01680	COG0494	nUDIX hydrolase
CSC3H3_RS01690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CSC3H3_RS01695	COG0174	glutamine synthetase
CSC3H3_RS01710	COG0625	glutathione transferase activity
CSC3H3_RS01720	COG4974	Belongs to the 'phage' integrase family
CSC3H3_RS01730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CSC3H3_RS01750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CSC3H3_RS01775	COG0300	oxidoreductase activity
CSC3H3_RS01780	COG0583	DNA-binding transcription factor activity
CSC3H3_RS01785	COG0784	Response regulator, receiver
CSC3H3_RS01790	COG4235	cytochrome complex assembly
CSC3H3_RS01795	COG1138	Cytochrome C-type biogenesis protein
CSC3H3_RS01805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CSC3H3_RS01810	COG1702	phosphate starvation-inducible protein PhoH
CSC3H3_RS01865	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CSC3H3_RS01870	COG0431	NADPH-dependent FMN reductase
CSC3H3_RS01910	COG0519	Catalyzes the synthesis of GMP from XMP
CSC3H3_RS01915	COG3842	ATPase activity
CSC3H3_RS01925	COG1178	ABC-type Fe3 transport system permease component
CSC3H3_RS01935	COG1872	DUF167
CSC3H3_RS01940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CSC3H3_RS01945	COG3214	Protein conserved in bacteria
CSC3H3_RS01950	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS01960	COG0395	ABC-type sugar transport system, permease component
CSC3H3_RS01970	COG1653	transport
CSC3H3_RS01980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CSC3H3_RS01990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CSC3H3_RS02005	COG1595	DNA-templated transcription, initiation
CSC3H3_RS02020	COG0066	3-isopropylmalate dehydratase activity
CSC3H3_RS02030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CSC3H3_RS02040	COG4106	trans-aconitate 2-methyltransferase activity
CSC3H3_RS02055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CSC3H3_RS02060	COG0228	four-way junction DNA binding
CSC3H3_RS02065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CSC3H3_RS02085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CSC3H3_RS02095	COG2217	Heavy metal translocating P-type atpase
CSC3H3_RS02125	COG0583	DNA-binding transcription factor activity
CSC3H3_RS02140	COG2010	Cytochrome c
CSC3H3_RS02165	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CSC3H3_RS02170	COG0126	phosphoglycerate kinase activity
CSC3H3_RS02180	COG1131	(ABC) transporter
CSC3H3_RS02220	COG4106	trans-aconitate 2-methyltransferase activity
CSC3H3_RS02230	COG0494	nUDIX hydrolase
CSC3H3_RS02240	COG0793	Belongs to the peptidase S41A family
CSC3H3_RS02245	COG4942	peptidase
CSC3H3_RS02250	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CSC3H3_RS02255	COG1760	l-serine dehydratase
CSC3H3_RS02260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CSC3H3_RS02280	COG0799	negative regulation of ribosome biogenesis
CSC3H3_RS02285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CSC3H3_RS02300	COG5265	(ABC) transporter
CSC3H3_RS02330	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CSC3H3_RS02335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CSC3H3_RS02365	COG1196	nuclear chromosome segregation
CSC3H3_RS02370	COG5336	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex
CSC3H3_RS02395	COG0435	Glutathione S-transferase
CSC3H3_RS02400	COG0583	DNA-binding transcription factor activity
CSC3H3_RS02420	COG0714	Associated with various cellular activities
CSC3H3_RS02455	COG3300	MHYT domain
CSC3H3_RS02455	COG5001	Diguanylate cyclase
CSC3H3_RS02460	COG4974	Belongs to the 'phage' integrase family
CSC3H3_RS02475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CSC3H3_RS02480	COG4536	flavin adenine dinucleotide binding
CSC3H3_RS02485	COG0517	IMP dehydrogenase activity
CSC3H3_RS02485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CSC3H3_RS02500	COG0271	Belongs to the BolA IbaG family
CSC3H3_RS02520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CSC3H3_RS02535	COG0625	glutathione transferase activity
CSC3H3_RS02545	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CSC3H3_RS02555	COG4774	siderophore transport
CSC3H3_RS02570	COG1238	metal cluster binding
CSC3H3_RS02640	COG4948	Mandelate Racemase Muconate Lactonizing
CSC3H3_RS02645	COG0583	DNA-binding transcription factor activity
CSC3H3_RS02650	COG0473	3-isopropylmalate dehydrogenase activity
CSC3H3_RS02670	COG3181	Tripartite tricarboxylate transporter family receptor
CSC3H3_RS02675	COG0583	DNA-binding transcription factor activity
CSC3H3_RS02680	COG5002	protein histidine kinase activity
CSC3H3_RS02695	COG1396	sequence-specific DNA binding
CSC3H3_RS02695	COG3800	Transcriptional regulator
CSC3H3_RS02720	COG0410	ABC transporter
CSC3H3_RS02730	COG1522	sequence-specific DNA binding
CSC3H3_RS02750	COG0019	diaminopimelate decarboxylase activity
CSC3H3_RS02760	COG1309	transcriptional regulator
CSC3H3_RS02770	COG1609	Transcriptional regulator
CSC3H3_RS02775	COG1129	ABC transporter
CSC3H3_RS02780	COG1172	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS02785	COG1879	ABC-type sugar transport system periplasmic component
CSC3H3_RS02800	COG0673	inositol 2-dehydrogenase activity
CSC3H3_RS02835	COG1522	sequence-specific DNA binding
CSC3H3_RS02840	COG3608	succinylglutamate desuccinylase aspartoacylase
CSC3H3_RS02845	COG0006	proline dipeptidase activity
CSC3H3_RS02850	COG2423	ornithine cyclodeaminase activity
CSC3H3_RS02855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CSC3H3_RS02865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS02870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CSC3H3_RS02875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CSC3H3_RS02880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSC3H3_RS02885	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CSC3H3_RS02915	COG4214	carbohydrate transport
CSC3H3_RS02925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CSC3H3_RS02930	COG1012	belongs to the aldehyde dehydrogenase family
CSC3H3_RS02940	COG1132	(ABC) transporter
CSC3H3_RS02940	COG1132	(ABC) transporter
CSC3H3_RS02945	COG1234	tRNA 3'-trailer cleavage
CSC3H3_RS02960	COG1733	regulation of RNA biosynthetic process
CSC3H3_RS02965	COG0604	alcohol dehydrogenase
CSC3H3_RS03055	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CSC3H3_RS03060	COG0280	phosphate acetyltransferase
CSC3H3_RS03060	COG0281	malic enzyme
CSC3H3_RS03065	COG2239	Acts as a magnesium transporter
CSC3H3_RS03115	COG0708	Exodeoxyribonuclease III
CSC3H3_RS03180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CSC3H3_RS03190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CSC3H3_RS03195	COG0706	membrane insertase activity
CSC3H3_RS03200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CSC3H3_RS03205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CSC3H3_RS03210	COG3706	GGDEF domain
CSC3H3_RS03215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CSC3H3_RS03220	COG0552	protein localization to endoplasmic reticulum
CSC3H3_RS03230	COG0783	Belongs to the Dps family
CSC3H3_RS03260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CSC3H3_RS03280	COG0742	ribosomal rna small subunit methyltransferase
CSC3H3_RS03285	COG1187	pseudouridine synthase activity
CSC3H3_RS03290	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CSC3H3_RS03295	COG0590	tRNA wobble adenosine to inosine editing
CSC3H3_RS03300	COG0300	oxidoreductase activity
CSC3H3_RS03310	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CSC3H3_RS03325	COG3550	peptidyl-serine autophosphorylation
CSC3H3_RS03335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CSC3H3_RS03340	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CSC3H3_RS03350	COG2204	response regulator
CSC3H3_RS03355	COG3852	Histidine kinase
CSC3H3_RS03360	COG0151	Belongs to the GarS family
CSC3H3_RS03365	COG1570	exodeoxyribonuclease VII activity
CSC3H3_RS03375	COG0405	Gamma-glutamyltransferase
CSC3H3_RS03380	COG1846	Transcriptional regulator
CSC3H3_RS03395	COG1663	tetraacyldisaccharide 4'-kinase activity
CSC3H3_RS03400	COG1519	Transferase
CSC3H3_RS03410	COG1132	(ABC) transporter
CSC3H3_RS03420	COG0438	transferase activity, transferring glycosyl groups
CSC3H3_RS03430	COG1597	lipid kinase activity
CSC3H3_RS03470	COG0840	transmembrane signaling receptor activity
CSC3H3_RS03475	COG0840	transmembrane signaling receptor activity
CSC3H3_RS03480	COG0840	transmembrane signaling receptor activity
CSC3H3_RS03485	COG0312	modulator of DNA gyrase
CSC3H3_RS03505	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CSC3H3_RS03525	COG0583	DNA-binding transcription factor activity
CSC3H3_RS03530	COG2814	Major facilitator Superfamily
CSC3H3_RS03535	COG2264	protein methyltransferase activity
CSC3H3_RS03540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CSC3H3_RS03570	COG3639	organic phosphonate transmembrane transporter activity
CSC3H3_RS03585	COG1349	DNA-binding transcription factor activity
CSC3H3_RS03620	COG1280	lysine exporter protein (LysE YggA)
CSC3H3_RS03630	COG4608	Belongs to the ABC transporter superfamily
CSC3H3_RS03635	COG0444	Belongs to the ABC transporter superfamily
CSC3H3_RS03640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSC3H3_RS03645	COG0601	transmembrane transport
CSC3H3_RS03650	COG0747	negative chemotaxis
CSC3H3_RS03680	COG0312	modulator of DNA gyrase
CSC3H3_RS03690	COG1612	heme a metabolic process
CSC3H3_RS03695	COG1648	precorrin-2 dehydrogenase activity
CSC3H3_RS03695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CSC3H3_RS03700	COG0175	sulfate reduction
CSC3H3_RS03705	COG1228	amidohydrolase
CSC3H3_RS03715	COG3046	protein related to deoxyribodipyrimidine photolyase
CSC3H3_RS03735	COG1522	sequence-specific DNA binding
CSC3H3_RS03740	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CSC3H3_RS03750	COG4953	penicillin-binding protein 1C
CSC3H3_RS03760	COG0583	DNA-binding transcription factor activity
CSC3H3_RS03765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS03775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSC3H3_RS03780	COG3265	gluconokinase activity
CSC3H3_RS03790	COG1609	Transcriptional regulator
CSC3H3_RS03795	COG1739	Uncharacterized protein family UPF0029
CSC3H3_RS03810	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CSC3H3_RS03825	COG2442	InterPro IPR007367
CSC3H3_RS03835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CSC3H3_RS03840	COG0215	cysteine-tRNA ligase activity
CSC3H3_RS03870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CSC3H3_RS03880	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CSC3H3_RS03885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CSC3H3_RS03895	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CSC3H3_RS03900	COG2962	Rard protein
CSC3H3_RS03920	COG0583	DNA-binding transcription factor activity
CSC3H3_RS03930	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CSC3H3_RS03950	COG0643	Histidine kinase
CSC3H3_RS03950	COG0784	Response regulator, receiver
CSC3H3_RS03950	COG2198	Histidine kinase
CSC3H3_RS03960	COG0745	RESPONSE REGULATOR receiver
CSC3H3_RS04000	COG0861	Integral membrane protein TerC family
CSC3H3_RS04005	COG4134	Bacterial extracellular solute-binding protein
CSC3H3_RS04010	COG4135	transport system, permease component
CSC3H3_RS04015	COG4136	ATPase activity
CSC3H3_RS04020	COG3128	pkhd-type hydroxylase
CSC3H3_RS04040	COG0552	protein localization to endoplasmic reticulum
CSC3H3_RS04045	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CSC3H3_RS04050	COG2204	response regulator
CSC3H3_RS04055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CSC3H3_RS04060	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CSC3H3_RS04070	COG1766	The M ring may be actively involved in energy transduction
CSC3H3_RS04075	COG1749	Flagellar hook protein flgE
CSC3H3_RS04095	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CSC3H3_RS04110	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CSC3H3_RS04120	COG4786	Flagellar basal body rod
CSC3H3_RS04120	COG1256	bacterial-type flagellum assembly
CSC3H3_RS04135	COG1706	bacterial-type flagellum-dependent cell motility
CSC3H3_RS04150	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CSC3H3_RS04155	COG1673	EVE domain
CSC3H3_RS04170	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CSC3H3_RS04175	COG4786	Flagellar basal body rod
CSC3H3_RS04180	COG4786	Flagellar basal body rod
CSC3H3_RS04210	COG0745	RESPONSE REGULATOR receiver
CSC3H3_RS04250	COG1338	Plays a role in the flagellum-specific transport system
CSC3H3_RS04265	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CSC3H3_RS04275	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CSC3H3_RS04280	COG1815	bacterial-type flagellum-dependent cell motility
CSC3H3_RS04285	COG1558	bacterial-type flagellum-dependent cell motility
CSC3H3_RS04290	COG1677	Flagellar hook-basal body complex protein FliE
CSC3H3_RS04295	COG1987	bacterial-type flagellum assembly
CSC3H3_RS04300	COG1684	flagellar biosynthetic protein fliR
CSC3H3_RS04305	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CSC3H3_RS04415	COG0583	DNA-binding transcription factor activity
CSC3H3_RS04425	COG1335	isochorismatase
CSC3H3_RS04435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CSC3H3_RS04445	COG0438	transferase activity, transferring glycosyl groups
CSC3H3_RS04505	COG1643	Atp-dependent helicase
CSC3H3_RS04530	COG0583	DNA-binding transcription factor activity
CSC3H3_RS04540	COG2900	Belongs to the SlyX family
CSC3H3_RS04545	COG2084	Dehydrogenase
CSC3H3_RS04575	COG3386	PFAM SMP-30 Gluconolaconase
CSC3H3_RS04590	COG4178	(ABC) transporter
CSC3H3_RS04600	COG1629	transport
CSC3H3_RS04600	COG4774	siderophore transport
CSC3H3_RS04605	COG1199	ATP-dependent helicase activity
CSC3H3_RS04625	COG0508	dehydrogenase complex catalyzes the overall conversion of
CSC3H3_RS04625	COG0596	Alpha beta hydrolase
CSC3H3_RS04630	COG2814	Major facilitator Superfamily
CSC3H3_RS04635	COG1309	transcriptional regulator
CSC3H3_RS04640	COG1238	metal cluster binding
CSC3H3_RS04650	COG1764	response to oxidative stress
CSC3H3_RS04660	COG1846	Transcriptional regulator
CSC3H3_RS04685	COG2199	diguanylate cyclase activity
CSC3H3_RS04685	COG2202	Pas domain
CSC3H3_RS04685	COG2200	EAL domain
CSC3H3_RS04715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CSC3H3_RS04725	COG1609	Transcriptional regulator
CSC3H3_RS04730	COG1840	ABC-type Fe3 transport system, periplasmic component
CSC3H3_RS04740	COG3842	ATPase activity
CSC3H3_RS04860	COG0625	glutathione transferase activity
CSC3H3_RS04865	COG0625	glutathione transferase activity
CSC3H3_RS04895	COG1733	regulation of RNA biosynthetic process
CSC3H3_RS04920	COG3842	ATPase activity
CSC3H3_RS04925	COG0395	ABC-type sugar transport system, permease component
CSC3H3_RS04935	COG2182	Extracellular solute-binding protein
CSC3H3_RS04940	COG0626	cystathionine gamma-synthase activity
CSC3H3_RS04945	COG2186	Transcriptional regulator
CSC3H3_RS04965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CSC3H3_RS04970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CSC3H3_RS04975	COG0028	Belongs to the TPP enzyme family
CSC3H3_RS05000	COG1309	transcriptional regulator
CSC3H3_RS05025	COG2391	methyltransferase activity
CSC3H3_RS05035	COG0513	Belongs to the DEAD box helicase family
CSC3H3_RS05040	COG1278	Cold shock
CSC3H3_RS05050	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CSC3H3_RS05055	COG0765	amino acid transport
CSC3H3_RS05060	COG0765	amino acid transport
CSC3H3_RS05075	COG1671	Belongs to the UPF0178 family
CSC3H3_RS05080	COG1012	belongs to the aldehyde dehydrogenase family
CSC3H3_RS05095	COG2130	NADP-dependent
CSC3H3_RS05100	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CSC3H3_RS05115	COG0523	cobalamin synthesis protein
CSC3H3_RS05120	COG1309	transcriptional regulator
CSC3H3_RS05130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CSC3H3_RS05150	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CSC3H3_RS05150	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CSC3H3_RS05155	COG3180	Ammonia monooxygenase
CSC3H3_RS05185	COG5001	Diguanylate cyclase
CSC3H3_RS05185	COG3300	MHYT domain
CSC3H3_RS05195	COG0745	RESPONSE REGULATOR receiver
CSC3H3_RS05200	COG1366	Belongs to the anti-sigma-factor antagonist family
CSC3H3_RS05205	COG2204	response regulator
CSC3H3_RS05220	COG0784	Response regulator, receiver
CSC3H3_RS05220	COG5002	protein histidine kinase activity
CSC3H3_RS05230	COG0006	proline dipeptidase activity
CSC3H3_RS05270	COG0772	Belongs to the SEDS family
CSC3H3_RS05275	COG0768	penicillin binding
CSC3H3_RS05305	COG1280	lysine exporter protein (LysE YggA)
CSC3H3_RS05325	COG1278	Cold shock
CSC3H3_RS05330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CSC3H3_RS05335	COG5285	phytanoyl-CoA dioxygenase
CSC3H3_RS05375	COG0840	transmembrane signaling receptor activity
CSC3H3_RS05390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CSC3H3_RS05390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CSC3H3_RS05405	COG0519	Catalyzes the synthesis of GMP from XMP
CSC3H3_RS05440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CSC3H3_RS05460	COG2814	Major facilitator Superfamily
CSC3H3_RS05475	COG2217	Heavy metal translocating P-type atpase
CSC3H3_RS05510	COG1012	belongs to the aldehyde dehydrogenase family
CSC3H3_RS05515	COG0596	Alpha beta hydrolase
CSC3H3_RS05520	COG0494	nUDIX hydrolase
CSC3H3_RS05565	COG1653	transport
CSC3H3_RS05580	COG0366	Alpha amylase catalytic
CSC3H3_RS05585	COG3842	ATPase activity
CSC3H3_RS05590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CSC3H3_RS05595	COG0363	glucosamine-6-phosphate deaminase activity
CSC3H3_RS05600	COG0129	dihydroxy-acid dehydratase activity
CSC3H3_RS05605	COG0837	glucose binding
CSC3H3_RS05610	COG0800	Aldolase
CSC3H3_RS05635	COG0826	peptidase U32
CSC3H3_RS05640	COG0826	peptidase U32
CSC3H3_RS05650	COG0573	inorganic phosphate transmembrane transporter activity
CSC3H3_RS05660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CSC3H3_RS05665	COG1250	3-hydroxyacyl-CoA dehydrogenase
CSC3H3_RS05665	COG0824	Thioesterase
CSC3H3_RS05670	COG3246	L-lysine catabolic process to acetate
CSC3H3_RS05675	COG4977	sequence-specific DNA binding
CSC3H3_RS05695	COG2719	SpoVR family
CSC3H3_RS05700	COG2718	Belongs to the UPF0229 family
CSC3H3_RS05705	COG2766	serine protein kinase
CSC3H3_RS05710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CSC3H3_RS05740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CSC3H3_RS05755	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CSC3H3_RS05765	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CSC3H3_RS05775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CSC3H3_RS05785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CSC3H3_RS05790	COG0222	ribosome binding
CSC3H3_RS05795	COG0085	RNA polymerase activity
CSC3H3_RS05800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CSC3H3_RS05820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CSC3H3_RS05830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CSC3H3_RS05835	COG0088	Forms part of the polypeptide exit tunnel
CSC3H3_RS05840	COG0089	rRNA binding
CSC3H3_RS05850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CSC3H3_RS05855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CSC3H3_RS05860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CSC3H3_RS05865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CSC3H3_RS05870	COG0255	Belongs to the universal ribosomal protein uL29 family
CSC3H3_RS05880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CSC3H3_RS05885	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CSC3H3_RS05890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CSC3H3_RS05900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CSC3H3_RS05910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CSC3H3_RS05920	COG1841	ribosomal large subunit assembly
CSC3H3_RS05925	COG0200	Binds to the 23S rRNA
CSC3H3_RS05930	COG0201	protein transport
CSC3H3_RS05935	COG0563	adenylate kinase activity
CSC3H3_RS05940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CSC3H3_RS05945	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CSC3H3_RS05955	COG0203	ribosomal protein L17
CSC3H3_RS05960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CSC3H3_RS05965	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CSC3H3_RS05970	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CSC3H3_RS05980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CSC3H3_RS05985	COG0564	pseudouridine synthase activity
CSC3H3_RS05995	COG0546	phosphoglycolate phosphatase activity
CSC3H3_RS06015	COG0412	Dienelactone hydrolase
CSC3H3_RS06020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CSC3H3_RS06045	COG5001	Diguanylate cyclase
CSC3H3_RS06050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CSC3H3_RS06055	COG4770	biotin carboxylase activity
CSC3H3_RS06060	COG4221	oxidoreductase activity
CSC3H3_RS06075	COG1254	Belongs to the acylphosphatase family
CSC3H3_RS06085	COG1595	DNA-templated transcription, initiation
CSC3H3_RS06095	COG4774	siderophore transport
CSC3H3_RS06100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CSC3H3_RS06110	COG0277	FAD linked oxidase domain protein
CSC3H3_RS06115	COG0009	L-threonylcarbamoyladenylate synthase
CSC3H3_RS06130	COG0583	DNA-binding transcription factor activity
CSC3H3_RS06140	COG1355	regulation of microtubule-based process
CSC3H3_RS06160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CSC3H3_RS06175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CSC3H3_RS06180	COG2011	ABC-type metal ion transport system permease component
CSC3H3_RS06190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CSC3H3_RS06210	COG0488	(ABC) transporter
CSC3H3_RS06215	COG0105	UTP biosynthetic process
CSC3H3_RS06235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CSC3H3_RS06240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CSC3H3_RS06250	COG0628	permease
CSC3H3_RS06255	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CSC3H3_RS06260	COG4067	protein conserved in archaea
CSC3H3_RS06260	COG0189	ligase activity
CSC3H3_RS06265	COG0189	ligase activity
CSC3H3_RS06275	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CSC3H3_RS06290	COG1733	regulation of RNA biosynthetic process
CSC3H3_RS06300	COG0583	DNA-binding transcription factor activity
CSC3H3_RS06310	COG0248	Ppx GppA phosphatase
CSC3H3_RS06315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CSC3H3_RS06340	COG0640	Transcriptional regulator
CSC3H3_RS06345	COG0123	including yeast histone deacetylase and acetoin utilization protein
CSC3H3_RS06365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CSC3H3_RS06380	COG1063	alcohol dehydrogenase
CSC3H3_RS06390	COG0318	PFAM AMP-dependent synthetase and ligase
CSC3H3_RS06420	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CSC3H3_RS06425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS06435	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CSC3H3_RS06445	COG3210	domain, Protein
CSC3H3_RS06445	COG2911	Protein conserved in bacteria
CSC3H3_RS06450	COG0583	DNA-binding transcription factor activity
CSC3H3_RS06475	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CSC3H3_RS06480	COG1295	ribonuclease BN
CSC3H3_RS06490	COG0668	transmembrane transport
CSC3H3_RS06495	COG0427	acetyl-CoA hydrolase
CSC3H3_RS06505	COG0484	heat shock protein binding
CSC3H3_RS06510	COG4520	surface antigen
CSC3H3_RS06520	COG0640	Transcriptional regulator
CSC3H3_RS06530	COG2135	peptidase activity
CSC3H3_RS06535	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS06550	COG0667	Aldo Keto reductase
CSC3H3_RS06570	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS06575	COG2207	Transcriptional regulator
CSC3H3_RS06580	COG0156	8-amino-7-oxononanoate synthase activity
CSC3H3_RS06590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CSC3H3_RS06605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSC3H3_RS06610	COG0601	transmembrane transport
CSC3H3_RS06615	COG0747	negative chemotaxis
CSC3H3_RS06620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CSC3H3_RS06625	COG1024	Enoyl-CoA hydratase
CSC3H3_RS06635	COG2814	Major facilitator Superfamily
CSC3H3_RS06640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS06645	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CSC3H3_RS06675	COG0656	L-ascorbic acid biosynthetic process
CSC3H3_RS06685	COG2070	2-Nitropropane dioxygenase
CSC3H3_RS06690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CSC3H3_RS06700	COG1252	NADH dehydrogenase
CSC3H3_RS06715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CSC3H3_RS06720	COG0583	DNA-binding transcription factor activity
CSC3H3_RS06725	COG3622	Belongs to the hyi family
CSC3H3_RS06745	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CSC3H3_RS06775	COG3135	benzoate transporter
CSC3H3_RS06805	COG0483	inositol monophosphate 1-phosphatase activity
CSC3H3_RS06810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CSC3H3_RS06820	COG0583	DNA-binding transcription factor activity
CSC3H3_RS06825	COG0352	thiamine-phosphate diphosphorylase activity
CSC3H3_RS06855	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CSC3H3_RS06865	COG1692	metallophosphoesterase
CSC3H3_RS06875	COG2207	Transcriptional regulator
CSC3H3_RS06880	COG1914	H( )-stimulated, divalent metal cation uptake system
CSC3H3_RS06910	COG0217	transcriptional regulatory protein
CSC3H3_RS06920	COG0632	four-way junction helicase activity
CSC3H3_RS06930	COG0824	Thioesterase
CSC3H3_RS06955	COG2885	chlorophyll binding
CSC3H3_RS06965	COG0037	tRNA processing
CSC3H3_RS06975	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CSC3H3_RS06985	COG2205	protein histidine kinase activity
CSC3H3_RS06995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CSC3H3_RS07000	COG0352	thiamine-phosphate diphosphorylase activity
CSC3H3_RS07000	COG0351	phosphomethylpyrimidine kinase
CSC3H3_RS07020	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CSC3H3_RS07030	COG0129	dihydroxy-acid dehydratase activity
CSC3H3_RS07035	COG0686	Belongs to the AlaDH PNT family
CSC3H3_RS07040	COG1522	sequence-specific DNA binding
CSC3H3_RS07060	COG1177	transmembrane transport
CSC3H3_RS07065	COG1176	ABC-type spermidine putrescine transport system, permease component I
CSC3H3_RS07070	COG3842	ATPase activity
CSC3H3_RS07075	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CSC3H3_RS07080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CSC3H3_RS07085	COG0174	glutamine synthetase
CSC3H3_RS07095	COG4948	Mandelate Racemase Muconate Lactonizing
CSC3H3_RS07100	COG3706	GGDEF domain
CSC3H3_RS07125	COG4095	Psort location CytoplasmicMembrane, score
CSC3H3_RS07150	COG0842	Transport permease protein
CSC3H3_RS07155	COG1129	ABC transporter
CSC3H3_RS07155	COG0842	Transport permease protein
CSC3H3_RS07160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CSC3H3_RS07165	COG0247	lactate metabolic process
CSC3H3_RS07165	COG0277	FAD linked oxidase domain protein
CSC3H3_RS07170	COG0583	DNA-binding transcription factor activity
CSC3H3_RS07180	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CSC3H3_RS07185	COG4221	oxidoreductase activity
CSC3H3_RS07190	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS07210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CSC3H3_RS07215	COG2076	Multidrug Resistance protein
CSC3H3_RS07225	COG0583	DNA-binding transcription factor activity
CSC3H3_RS07245	COG0432	Pfam Uncharacterised protein family UPF0047
CSC3H3_RS07250	COG3384	dioxygenase
CSC3H3_RS07270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CSC3H3_RS07275	COG3761	NADH ubiquinone oxidoreductase 17.2 kD subunit
CSC3H3_RS07290	COG4765	Protein conserved in bacteria
CSC3H3_RS07310	COG0534	Mate efflux family protein
CSC3H3_RS07315	COG1522	sequence-specific DNA binding
CSC3H3_RS07325	COG1959	2 iron, 2 sulfur cluster binding
CSC3H3_RS07330	COG0513	Belongs to the DEAD box helicase family
CSC3H3_RS07350	COG3038	cytochrome b561
CSC3H3_RS07355	COG2066	Belongs to the glutaminase family
CSC3H3_RS07360	COG0187	DNA topoisomerase II activity
CSC3H3_RS07375	COG0583	DNA-binding transcription factor activity
CSC3H3_RS07385	COG4221	oxidoreductase activity
CSC3H3_RS07400	COG4608	Belongs to the ABC transporter superfamily
CSC3H3_RS07405	COG0444	Belongs to the ABC transporter superfamily
CSC3H3_RS07410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSC3H3_RS07415	COG0601	transmembrane transport
CSC3H3_RS07465	COG0469	pyruvate kinase activity
CSC3H3_RS07490	COG0693	protein deglycase activity
CSC3H3_RS07500	COG0668	transmembrane transport
CSC3H3_RS07515	COG1832	CoA-binding protein
CSC3H3_RS07525	COG1280	lysine exporter protein (LysE YggA)
CSC3H3_RS07535	COG4774	siderophore transport
CSC3H3_RS07545	COG1024	Enoyl-CoA hydratase
CSC3H3_RS07560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CSC3H3_RS07565	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CSC3H3_RS07580	COG2194	sulfuric ester hydrolase activity
CSC3H3_RS07610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CSC3H3_RS07615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CSC3H3_RS07620	COG0697	spore germination
CSC3H3_RS07625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CSC3H3_RS07635	COG1858	cytochrome C peroxidase
CSC3H3_RS07640	COG0640	Transcriptional regulator
CSC3H3_RS07650	COG2084	Dehydrogenase
CSC3H3_RS07655	COG3243	poly(R)-hydroxyalkanoic acid synthase
CSC3H3_RS07665	COG0436	Aminotransferase
CSC3H3_RS07675	COG1494	fructose-1,6-bisphosphatase
CSC3H3_RS07685	COG0443	Heat shock 70 kDa protein
CSC3H3_RS07690	COG1309	transcriptional regulator
CSC3H3_RS07695	COG1064	alcohol dehydrogenase
CSC3H3_RS07725	COG2271	Major facilitator Superfamily
CSC3H3_RS07745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CSC3H3_RS07765	COG1234	tRNA 3'-trailer cleavage
CSC3H3_RS07780	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CSC3H3_RS07785	COG0840	transmembrane signaling receptor activity
CSC3H3_RS07785	COG2972	Histidine kinase
CSC3H3_RS07805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CSC3H3_RS07830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CSC3H3_RS07845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CSC3H3_RS07850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CSC3H3_RS07855	COG1116	anion transmembrane transporter activity
CSC3H3_RS07865	COG0583	DNA-binding transcription factor activity
CSC3H3_RS07870	COG0123	including yeast histone deacetylase and acetoin utilization protein
CSC3H3_RS07915	COG0523	cobalamin synthesis protein
CSC3H3_RS07925	COG0735	belongs to the Fur family
CSC3H3_RS07930	COG1121	(ABC) transporter
CSC3H3_RS07935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CSC3H3_RS07940	COG0626	cystathionine gamma-synthase activity
CSC3H3_RS07945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CSC3H3_RS07965	COG2897	thiosulfate sulfurtransferase activity
CSC3H3_RS07970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CSC3H3_RS07990	COG1088	dTDP-glucose 4,6-dehydratase activity
CSC3H3_RS08005	COG1620	l-lactate permease
CSC3H3_RS08015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CSC3H3_RS08030	COG2814	Major facilitator Superfamily
CSC3H3_RS08040	COG0494	nUDIX hydrolase
CSC3H3_RS08055	COG2195	Cleaves the N-terminal amino acid of tripeptides
CSC3H3_RS08125	COG0730	response to heat
CSC3H3_RS08130	COG0425	Belongs to the sulfur carrier protein TusA family
CSC3H3_RS08130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CSC3H3_RS08135	COG2153	protein acetylation
CSC3H3_RS08170	COG1067	ATP-dependent peptidase activity
CSC3H3_RS08175	COG3327	negative regulation of DNA-templated transcription, initiation
CSC3H3_RS08185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CSC3H3_RS08225	COG3273	potassium ion transport
CSC3H3_RS08225	COG0471	metal ion transport
CSC3H3_RS08240	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CSC3H3_RS08265	COG0564	pseudouridine synthase activity
CSC3H3_RS08280	COG0438	transferase activity, transferring glycosyl groups
CSC3H3_RS08285	COG1846	Transcriptional regulator
CSC3H3_RS08305	COG1216	Glycosyl transferase, family 2
CSC3H3_RS08305	COG0438	transferase activity, transferring glycosyl groups
CSC3H3_RS08310	COG2226	methyltransferase
CSC3H3_RS08365	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CSC3H3_RS08370	COG4175	Glycine betaine
CSC3H3_RS08375	COG4176	ABC-type proline glycine betaine transport system permease component
CSC3H3_RS08390	COG2113	Glycine betaine
CSC3H3_RS08395	COG4176	ABC-type proline glycine betaine transport system permease component
CSC3H3_RS08400	COG4175	Glycine betaine
CSC3H3_RS08430	COG1840	ABC-type Fe3 transport system, periplasmic component
CSC3H3_RS08445	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CSC3H3_RS08460	COG0438	transferase activity, transferring glycosyl groups
CSC3H3_RS08470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CSC3H3_RS08495	COG0747	negative chemotaxis
CSC3H3_RS08500	COG0601	transmembrane transport
CSC3H3_RS08505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSC3H3_RS08515	COG2814	Major facilitator Superfamily
CSC3H3_RS08520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CSC3H3_RS08520	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CSC3H3_RS08525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CSC3H3_RS08530	COG1393	Belongs to the ArsC family
CSC3H3_RS08535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CSC3H3_RS08540	COG0405	Gamma-glutamyltransferase
CSC3H3_RS08555	COG2363	Small membrane protein
CSC3H3_RS08560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CSC3H3_RS08565	COG0793	Belongs to the peptidase S41A family
CSC3H3_RS08580	COG0557	exoribonuclease II activity
CSC3H3_RS08585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CSC3H3_RS08590	COG0758	DNA mediated transformation
CSC3H3_RS08595	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CSC3H3_RS08600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CSC3H3_RS08620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CSC3H3_RS08625	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CSC3H3_RS08635	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CSC3H3_RS08640	COG0431	NADPH-dependent FMN reductase
CSC3H3_RS08655	COG2223	nitrite transmembrane transporter activity
CSC3H3_RS08665	COG1435	thymidine kinase activity
CSC3H3_RS08680	COG2995	paraquat-inducible protein a
CSC3H3_RS08685	COG3008	intermembrane lipid transfer
CSC3H3_RS08685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CSC3H3_RS08700	COG4977	sequence-specific DNA binding
CSC3H3_RS08705	COG2814	Major facilitator Superfamily
CSC3H3_RS08715	COG0625	glutathione transferase activity
CSC3H3_RS08755	COG0174	glutamine synthetase
CSC3H3_RS08765	COG1454	alcohol dehydrogenase
CSC3H3_RS08770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CSC3H3_RS08770	COG0519	Catalyzes the synthesis of GMP from XMP
CSC3H3_RS08775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CSC3H3_RS08780	COG0737	Belongs to the 5'-nucleotidase family
CSC3H3_RS08785	COG1744	ABC transporter substrate-binding protein PnrA-like
CSC3H3_RS08790	COG3845	ABC transporter
CSC3H3_RS08800	COG1079	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS08810	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CSC3H3_RS08815	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CSC3H3_RS08830	COG0559	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS08840	COG0411	ABC transporter
CSC3H3_RS08865	COG1126	abc transporter atp-binding protein
CSC3H3_RS08870	COG0765	amino acid transport
CSC3H3_RS08875	COG4597	amino acid ABC transporter
CSC3H3_RS08880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CSC3H3_RS08885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CSC3H3_RS08890	COG0521	Mo-molybdopterin cofactor biosynthetic process
CSC3H3_RS08900	COG0840	transmembrane signaling receptor activity
CSC3H3_RS08905	COG4335	DNA alkylation repair
CSC3H3_RS08915	COG1414	Transcriptional regulator
CSC3H3_RS08920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CSC3H3_RS08955	COG2814	Major facilitator Superfamily
CSC3H3_RS08980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CSC3H3_RS08985	COG3022	response to hydroperoxide
CSC3H3_RS08990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CSC3H3_RS09015	COG0310	cobalt ion transport
CSC3H3_RS09035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CSC3H3_RS09035	COG1042	CoA-binding domain protein
CSC3H3_RS09035	COG0045	succinate-CoA ligase (ADP-forming) activity
CSC3H3_RS09055	COG4989	oxidoreductase activity
CSC3H3_RS09075	COG0840	transmembrane signaling receptor activity
CSC3H3_RS09080	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CSC3H3_RS09085	COG0425	Belongs to the sulfur carrier protein TusA family
CSC3H3_RS09085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CSC3H3_RS09090	COG1538	Outer membrane efflux protein
CSC3H3_RS09100	COG0525	valine-tRNA ligase activity
CSC3H3_RS09105	COG2329	Antibiotic biosynthesis monooxygenase
CSC3H3_RS09115	COG0512	Glutamine amidotransferase of anthranilate synthase
CSC3H3_RS09120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CSC3H3_RS09130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CSC3H3_RS09140	COG0316	Belongs to the HesB IscA family
CSC3H3_RS09155	COG1472	Belongs to the glycosyl hydrolase 3 family
CSC3H3_RS09160	COG1994	Peptidase M50
CSC3H3_RS09170	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CSC3H3_RS09175	COG3842	ATPase activity
CSC3H3_RS09180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CSC3H3_RS09185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CSC3H3_RS09190	COG0805	protein transport
CSC3H3_RS09195	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CSC3H3_RS09220	COG1862	Preprotein translocase
CSC3H3_RS09235	COG3737	Protein of unknown function (DUF498/DUF598)
CSC3H3_RS09240	COG0668	transmembrane transport
CSC3H3_RS09255	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CSC3H3_RS09265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CSC3H3_RS09270	COG0191	fructose-bisphosphate aldolase activity
CSC3H3_RS09280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CSC3H3_RS09285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CSC3H3_RS09290	COG2188	Transcriptional regulator
CSC3H3_RS09295	COG2971	BadF BadG BcrA BcrD
CSC3H3_RS09300	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CSC3H3_RS09305	COG1653	transport
CSC3H3_RS09310	COG1175	transmembrane transport
CSC3H3_RS09320	COG3842	ATPase activity
CSC3H3_RS09330	COG3842	ATPase activity
CSC3H3_RS09335	COG1176	ABC-type spermidine putrescine transport system, permease component I
CSC3H3_RS09340	COG1177	transmembrane transport
CSC3H3_RS09345	COG1653	transport
CSC3H3_RS09355	COG0395	ABC-type sugar transport system, permease component
CSC3H3_RS09360	COG3842	ATPase activity
CSC3H3_RS09365	COG1956	GAF domain-containing protein
CSC3H3_RS09370	COG0629	single-stranded DNA binding
CSC3H3_RS09385	COG3012	SEC-C Motif Domain Protein
CSC3H3_RS09420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CSC3H3_RS09430	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CSC3H3_RS09480	COG2951	lytic endotransglycosylase activity
CSC3H3_RS09490	COG1686	Belongs to the peptidase S11 family
CSC3H3_RS09495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CSC3H3_RS09510	COG0084	hydrolase, TatD family'
CSC3H3_RS09515	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CSC3H3_RS09515	COG0321	lipoyl(octanoyl) transferase activity
CSC3H3_RS09575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CSC3H3_RS09580	COG1917	Cupin 2, conserved barrel domain protein
CSC3H3_RS09585	COG0527	aspartate kinase activity
CSC3H3_RS09590	COG3956	TIGRFAM MazG family protein
CSC3H3_RS09600	COG0483	inositol monophosphate 1-phosphatase activity
CSC3H3_RS09605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CSC3H3_RS09615	COG0546	phosphoglycolate phosphatase activity
CSC3H3_RS09620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CSC3H3_RS09625	COG0569	domain protein
CSC3H3_RS09630	COG2204	response regulator
CSC3H3_RS09665	COG2917	probably involved in intracellular septation
CSC3H3_RS09700	COG0416	fatty acid biosynthetic process
CSC3H3_RS09720	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CSC3H3_RS09725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CSC3H3_RS09730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CSC3H3_RS09735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CSC3H3_RS09735	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CSC3H3_RS09745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CSC3H3_RS09745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CSC3H3_RS09750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CSC3H3_RS09760	COG0698	ribose 5-phosphate isomerase
CSC3H3_RS09810	COG1024	Enoyl-CoA hydratase
CSC3H3_RS09815	COG1960	acyl-CoA dehydrogenase activity
CSC3H3_RS09835	COG0113	porphobilinogen synthase activity
CSC3H3_RS09840	COG1011	Hydrolase
CSC3H3_RS09850	COG0318	PFAM AMP-dependent synthetase and ligase
CSC3H3_RS09860	COG1012	belongs to the aldehyde dehydrogenase family
CSC3H3_RS09865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CSC3H3_RS09870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CSC3H3_RS09875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CSC3H3_RS09880	COG1360	Flagellar Motor Protein
CSC3H3_RS09885	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CSC3H3_RS09890	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CSC3H3_RS09895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS09905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CSC3H3_RS09910	COG1381	Involved in DNA repair and RecF pathway recombination
CSC3H3_RS09920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CSC3H3_RS09930	COG0681	Belongs to the peptidase S26 family
CSC3H3_RS09935	COG0736	holo-[acyl-carrier-protein] synthase activity
CSC3H3_RS09940	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CSC3H3_RS09960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CSC3H3_RS09970	COG1573	uracil-dna glycosylase
CSC3H3_RS09975	COG0514	ATP-dependent DNA helicase (RecQ)
CSC3H3_RS09980	COG0386	Belongs to the glutathione peroxidase family
CSC3H3_RS09985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CSC3H3_RS09990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CSC3H3_RS09995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CSC3H3_RS10000	COG0741	lytic transglycosylase activity
CSC3H3_RS10015	COG0739	heme binding
CSC3H3_RS10020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CSC3H3_RS10025	COG1546	Belongs to the CinA family
CSC3H3_RS10025	COG1058	Belongs to the CinA family
CSC3H3_RS10030	COG2867	negative regulation of translational initiation
CSC3H3_RS10035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CSC3H3_RS10040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CSC3H3_RS10045	COG0508	dehydrogenase complex catalyzes the overall conversion of
CSC3H3_RS10050	COG0508	dehydrogenase complex catalyzes the overall conversion of
CSC3H3_RS10050	COG0022	dehydrogenase e1 component
CSC3H3_RS10055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CSC3H3_RS10065	COG0148	phosphopyruvate hydratase activity
CSC3H3_RS10085	COG0149	triose-phosphate isomerase activity
CSC3H3_RS10090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CSC3H3_RS10095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CSC3H3_RS10100	COG2861	carbohydrate metabolic process
CSC3H3_RS10120	COG0315	cyclic pyranopterin monophosphate synthase activity
CSC3H3_RS10130	COG0658	competence protein
CSC3H3_RS10130	COG2333	competence protein COMEC
CSC3H3_RS10140	COG0372	Belongs to the citrate synthase family
CSC3H3_RS10145	COG0346	lactoylglutathione lyase activity
CSC3H3_RS10150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CSC3H3_RS10155	COG3494	Protein of unknown function (DUF1009)
CSC3H3_RS10160	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CSC3H3_RS10170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CSC3H3_RS10185	COG0750	zinc metalloprotease
CSC3H3_RS10190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CSC3H3_RS10200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CSC3H3_RS10215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CSC3H3_RS10220	COG0052	Belongs to the universal ribosomal protein uS2 family
CSC3H3_RS10230	COG1136	(ABC) transporter
CSC3H3_RS10240	COG0442	prolyl-tRNA aminoacylation
CSC3H3_RS10255	COG0346	lactoylglutathione lyase activity
CSC3H3_RS10290	COG0713	ATP synthesis coupled electron transport
CSC3H3_RS10305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CSC3H3_RS10310	COG1034	ATP synthesis coupled electron transport
CSC3H3_RS10315	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CSC3H3_RS10320	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CSC3H3_RS10340	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CSC3H3_RS10350	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CSC3H3_RS10365	COG0776	regulation of translation
CSC3H3_RS10380	COG0740	serine-type endopeptidase activity
CSC3H3_RS10400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CSC3H3_RS10400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CSC3H3_RS10410	COG2202	Pas domain
CSC3H3_RS10410	COG2205	protein histidine kinase activity
CSC3H3_RS10425	COG2217	Heavy metal translocating P-type atpase
CSC3H3_RS10455	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CSC3H3_RS10465	COG1175	transmembrane transport
CSC3H3_RS10470	COG0395	ABC-type sugar transport system, permease component
CSC3H3_RS10475	COG3842	ATPase activity
CSC3H3_RS10480	COG0840	transmembrane signaling receptor activity
CSC3H3_RS10480	COG5278	phosphoserine phosphatase activity
CSC3H3_RS10500	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CSC3H3_RS10525	COG0010	Belongs to the arginase family
CSC3H3_RS10530	COG1012	belongs to the aldehyde dehydrogenase family
CSC3H3_RS10535	COG1396	sequence-specific DNA binding
CSC3H3_RS10535	COG1917	Cupin 2, conserved barrel domain protein
CSC3H3_RS10540	COG0174	glutamine synthetase
CSC3H3_RS10550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CSC3H3_RS10555	COG2346	COG2346, Truncated hemoglobins
CSC3H3_RS10565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CSC3H3_RS10585	COG1309	transcriptional regulator
CSC3H3_RS10600	COG0517	IMP dehydrogenase activity
CSC3H3_RS10600	COG4175	Glycine betaine
CSC3H3_RS10610	COG0583	DNA-binding transcription factor activity
CSC3H3_RS10620	COG1177	transmembrane transport
CSC3H3_RS10630	COG3842	ATPase activity
CSC3H3_RS10635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CSC3H3_RS10640	COG3246	L-lysine catabolic process to acetate
CSC3H3_RS10655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CSC3H3_RS10660	COG0251	oxidation-reduction process
CSC3H3_RS10690	COG2423	ornithine cyclodeaminase activity
CSC3H3_RS10730	COG3616	Alanine racemase, N-terminal domain
CSC3H3_RS10740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSC3H3_RS10745	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CSC3H3_RS10745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS10755	COG0251	oxidation-reduction process
CSC3H3_RS10775	COG0729	surface antigen
CSC3H3_RS10780	COG0189	ligase activity
CSC3H3_RS10785	COG0454	-acetyltransferase
CSC3H3_RS10785	COG0456	acetyltransferase
CSC3H3_RS10820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CSC3H3_RS10825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CSC3H3_RS10830	COG3485	protocatechuate 3,4-dioxygenase
CSC3H3_RS10835	COG3485	protocatechuate 3,4-dioxygenase
CSC3H3_RS10845	COG0596	Alpha beta hydrolase
CSC3H3_RS10850	COG0583	DNA-binding transcription factor activity
CSC3H3_RS10880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CSC3H3_RS10915	COG2814	Major facilitator Superfamily
CSC3H3_RS10925	COG2375	cellular response to nickel ion
CSC3H3_RS10940	COG4172	Belongs to the ABC transporter superfamily
CSC3H3_RS10945	COG0747	negative chemotaxis
CSC3H3_RS10955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSC3H3_RS10995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CSC3H3_RS11010	COG0308	aminopeptidase N
CSC3H3_RS11040	COG0671	phosphoesterase, PA-phosphatase related
CSC3H3_RS11045	COG2205	protein histidine kinase activity
CSC3H3_RS11055	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CSC3H3_RS11060	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CSC3H3_RS11065	COG0840	transmembrane signaling receptor activity
CSC3H3_RS11070	COG4977	sequence-specific DNA binding
CSC3H3_RS11085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CSC3H3_RS11090	COG1120	ATPase activity
CSC3H3_RS11110	COG0848	biopolymer transport protein
CSC3H3_RS11115	COG0811	peptide transport
CSC3H3_RS11135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CSC3H3_RS11140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CSC3H3_RS11145	COG0697	spore germination
CSC3H3_RS11175	COG0418	dihydroorotase activity
CSC3H3_RS11190	COG0436	Aminotransferase
CSC3H3_RS11205	COG5001	Diguanylate cyclase
CSC3H3_RS11205	COG5002	protein histidine kinase activity
CSC3H3_RS11205	COG3447	MASE1 domain protein
CSC3H3_RS11215	COG1765	OsmC-like protein
CSC3H3_RS11240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CSC3H3_RS11245	COG0457	Tetratricopeptide repeat
CSC3H3_RS11260	COG1917	Cupin 2, conserved barrel domain protein
CSC3H3_RS11260	COG2207	Transcriptional regulator
CSC3H3_RS11280	COG3287	FIST C domain
CSC3H3_RS11280	COG2199	diguanylate cyclase activity
CSC3H3_RS11280	COG2200	EAL domain
CSC3H3_RS11285	COG2824	Alkylphosphonate utilization operon protein PhnA
CSC3H3_RS11295	COG0583	DNA-binding transcription factor activity
CSC3H3_RS11320	COG0482	sulfurtransferase activity
CSC3H3_RS11325	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CSC3H3_RS11335	COG0633	Ferredoxin
CSC3H3_RS11340	COG0443	Heat shock 70 kDa protein
CSC3H3_RS11345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CSC3H3_RS11350	COG0316	Belongs to the HesB IscA family
CSC3H3_RS11355	COG0822	iron-sulfur transferase activity
CSC3H3_RS11375	COG1045	serine acetyltransferase
CSC3H3_RS11380	COG2945	thiolester hydrolase activity
CSC3H3_RS11400	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CSC3H3_RS11405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CSC3H3_RS11415	COG2833	Protein of unknown function (DUF455)
CSC3H3_RS11425	COG0583	DNA-binding transcription factor activity
CSC3H3_RS11435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CSC3H3_RS11460	COG1566	PFAM secretion protein HlyD family protein
CSC3H3_RS11470	COG3314	Sporulation integral membrane protein YlbJ
CSC3H3_RS11480	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CSC3H3_RS11485	COG0860	N-Acetylmuramoyl-L-alanine amidase
CSC3H3_RS11495	COG1530	ribonuclease E activity
CSC3H3_RS11500	COG0436	Aminotransferase
CSC3H3_RS11520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CSC3H3_RS11520	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CSC3H3_RS11530	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CSC3H3_RS11535	COG0511	ligase activity, forming carbon-carbon bonds
CSC3H3_RS11540	COG0439	Biotin carboxylase
CSC3H3_RS11560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CSC3H3_RS11570	COG0840	transmembrane signaling receptor activity
CSC3H3_RS11590	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CSC3H3_RS11610	COG1686	Belongs to the peptidase S11 family
CSC3H3_RS11620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CSC3H3_RS11625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CSC3H3_RS11640	COG1192	Involved in chromosome partitioning
CSC3H3_RS11650	COG0579	oxidoreductase
CSC3H3_RS11690	COG3655	Transcriptional regulator
CSC3H3_RS11710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CSC3H3_RS11715	COG1024	Enoyl-CoA hydratase
CSC3H3_RS11720	COG4770	biotin carboxylase activity
CSC3H3_RS11740	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CSC3H3_RS11755	COG0583	DNA-binding transcription factor activity
CSC3H3_RS11765	COG2326	polyphosphate kinase activity
CSC3H3_RS11770	COG2084	Dehydrogenase
CSC3H3_RS11775	COG0793	Belongs to the peptidase S41A family
CSC3H3_RS11780	COG1960	acyl-CoA dehydrogenase activity
CSC3H3_RS11785	COG0795	lipopolysaccharide-transporting ATPase activity
CSC3H3_RS11795	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CSC3H3_RS11800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CSC3H3_RS11810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CSC3H3_RS11815	COG0194	GDP metabolic process
CSC3H3_RS11820	COG1561	YicC-like family, N-terminal region
CSC3H3_RS11830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CSC3H3_RS11835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CSC3H3_RS11850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CSC3H3_RS11865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CSC3H3_RS11875	COG0359	binds to the 23S rRNA
CSC3H3_RS11880	COG0305	Participates in initiation and elongation during chromosome replication
CSC3H3_RS11885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CSC3H3_RS11890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CSC3H3_RS11910	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CSC3H3_RS11915	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS11925	COG1116	anion transmembrane transporter activity
CSC3H3_RS11930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CSC3H3_RS11945	COG1160	GTP binding
CSC3H3_RS11975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CSC3H3_RS11980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CSC3H3_RS11980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CSC3H3_RS11985	COG1476	TRANSCRIPTIONal
CSC3H3_RS12005	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CSC3H3_RS12010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CSC3H3_RS12020	COG1902	pentaerythritol trinitrate reductase activity
CSC3H3_RS12060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CSC3H3_RS12065	COG3152	Membrane
CSC3H3_RS12090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CSC3H3_RS12095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CSC3H3_RS12100	COG0546	phosphoglycolate phosphatase activity
CSC3H3_RS12115	COG0129	dihydroxy-acid dehydratase activity
CSC3H3_RS12120	COG4214	carbohydrate transport
CSC3H3_RS12130	COG4213	ABC transporter substrate-binding protein
CSC3H3_RS12140	COG0237	dephospho-CoA kinase activity
CSC3H3_RS12145	COG1525	nuclease
CSC3H3_RS12155	COG0406	alpha-ribazole phosphatase activity
CSC3H3_RS12175	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CSC3H3_RS12225	COG1283	sodium-dependent phosphate transmembrane transporter activity
CSC3H3_RS12235	COG0367	asparagine synthase
CSC3H3_RS12240	COG1522	sequence-specific DNA binding
CSC3H3_RS12245	COG3284	Transcriptional regulator
CSC3H3_RS12250	COG1012	belongs to the aldehyde dehydrogenase family
CSC3H3_RS12260	COG2855	membrane
CSC3H3_RS12270	COG0583	DNA-binding transcription factor activity
CSC3H3_RS12275	COG1271	oxidase subunit
CSC3H3_RS12280	COG1294	oxidase, subunit
CSC3H3_RS12295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CSC3H3_RS12310	COG1012	belongs to the aldehyde dehydrogenase family
CSC3H3_RS12315	COG3724	N-succinylarginine dihydrolase activity
CSC3H3_RS12320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CSC3H3_RS12325	COG1522	sequence-specific DNA binding
CSC3H3_RS12330	COG0175	sulfate reduction
CSC3H3_RS12350	COG0436	Aminotransferase
CSC3H3_RS12355	COG0659	secondary active sulfate transmembrane transporter activity
CSC3H3_RS12360	COG3842	ATPase activity
CSC3H3_RS12365	COG1176	ABC-type spermidine putrescine transport system, permease component I
CSC3H3_RS12370	COG1177	transmembrane transport
CSC3H3_RS12390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CSC3H3_RS12415	COG2827	Endonuclease containing a URI domain
CSC3H3_RS12420	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS12425	COG0800	Aldolase
CSC3H3_RS12430	COG3734	2-keto-3-deoxy-galactonokinase
CSC3H3_RS12435	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CSC3H3_RS12440	COG1309	transcriptional regulator
CSC3H3_RS12460	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CSC3H3_RS12465	COG1845	cytochrome c oxidase, subunit III
CSC3H3_RS12470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CSC3H3_RS12475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CSC3H3_RS12480	COG0477	Major facilitator Superfamily
CSC3H3_RS12485	COG0840	transmembrane signaling receptor activity
CSC3H3_RS12490	COG1959	2 iron, 2 sulfur cluster binding
CSC3H3_RS12500	COG0300	oxidoreductase activity
CSC3H3_RS12520	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CSC3H3_RS12540	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CSC3H3_RS12550	COG1215	transferase activity, transferring glycosyl groups
CSC3H3_RS12560	COG0583	DNA-binding transcription factor activity
CSC3H3_RS12565	COG0366	Alpha amylase catalytic
CSC3H3_RS12575	COG1414	Transcriptional regulator
CSC3H3_RS12580	COG1072	(Pantothenic acid kinase))
CSC3H3_RS12615	COG2186	Transcriptional regulator
CSC3H3_RS12620	COG1172	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS12625	COG1172	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS12630	COG1129	ABC transporter
CSC3H3_RS12635	COG1879	ABC-type sugar transport system periplasmic component
CSC3H3_RS12640	COG2017	converts alpha-aldose to the beta-anomer
CSC3H3_RS12655	COG3220	belongs to the UPF0276 family
CSC3H3_RS12665	COG0667	Aldo Keto reductase
CSC3H3_RS12670	COG2223	nitrite transmembrane transporter activity
CSC3H3_RS12685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CSC3H3_RS12685	COG2010	Cytochrome c
CSC3H3_RS12705	COG1840	ABC-type Fe3 transport system, periplasmic component
CSC3H3_RS12710	COG3842	ATPase activity
CSC3H3_RS12715	COG4208	sulfate ABC transporter
CSC3H3_RS12890	COG1132	(ABC) transporter
CSC3H3_RS12900	COG0254	rRNA binding
CSC3H3_RS12920	COG0604	alcohol dehydrogenase
CSC3H3_RS12935	COG1349	DNA-binding transcription factor activity
CSC3H3_RS12970	COG1309	transcriptional regulator
CSC3H3_RS12990	COG2807	transmembrane transport
CSC3H3_RS13015	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CSC3H3_RS13020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CSC3H3_RS13035	COG0242	peptide deformylase activity
CSC3H3_RS13040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CSC3H3_RS13080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CSC3H3_RS13090	COG1022	Amp-dependent synthetase and ligase
CSC3H3_RS13115	COG0542	response to heat
CSC3H3_RS13140	COG2890	protein-(glutamine-N5) methyltransferase activity
CSC3H3_RS13145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CSC3H3_RS13150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CSC3H3_RS13155	COG0124	histidyl-tRNA synthetase
CSC3H3_RS13160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CSC3H3_RS13165	COG1426	Protein conserved in bacteria
CSC3H3_RS13180	COG0527	aspartate kinase activity
CSC3H3_RS13195	COG1881	PFAM PEBP family protein
CSC3H3_RS13200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CSC3H3_RS13210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CSC3H3_RS13215	COG2199	diguanylate cyclase activity
CSC3H3_RS13235	COG1136	(ABC) transporter
CSC3H3_RS13250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CSC3H3_RS13265	COG0625	glutathione transferase activity
CSC3H3_RS13270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CSC3H3_RS13270	COG1017	nitric oxide dioxygenase activity
CSC3H3_RS13275	COG2226	methyltransferase
CSC3H3_RS13285	COG1489	DNA binding
CSC3H3_RS13290	COG0024	Methionine aminopeptidase
CSC3H3_RS13295	COG2814	Major facilitator Superfamily
CSC3H3_RS13300	COG1335	isochorismatase
CSC3H3_RS13320	COG2003	Belongs to the UPF0758 family
CSC3H3_RS13325	COG0346	lactoylglutathione lyase activity
CSC3H3_RS13335	COG1846	Transcriptional regulator
CSC3H3_RS13340	COG0667	Aldo Keto reductase
CSC3H3_RS13375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CSC3H3_RS13395	COG2986	histidine ammonia-lyase
CSC3H3_RS13425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CSC3H3_RS13435	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS13440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CSC3H3_RS13450	COG2207	Transcriptional regulator
CSC3H3_RS13480	COG0688	phosphatidylethanolamine metabolic process
CSC3H3_RS13515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CSC3H3_RS13535	COG0583	DNA-binding transcription factor activity
CSC3H3_RS13570	COG0538	isocitrate dehydrogenase activity
CSC3H3_RS13575	COG4221	oxidoreductase activity
CSC3H3_RS13580	COG2207	Transcriptional regulator
CSC3H3_RS13590	COG1595	DNA-templated transcription, initiation
CSC3H3_RS13600	COG1741	Belongs to the pirin family
CSC3H3_RS13605	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CSC3H3_RS13610	COG0655	NAD(P)H dehydrogenase (quinone) activity
CSC3H3_RS13615	COG0584	glycerophosphoryl diester phosphodiesterase
CSC3H3_RS13620	COG4187	Peptidase family M20/M25/M40
CSC3H3_RS13630	COG1846	Transcriptional regulator
CSC3H3_RS13640	COG0542	response to heat
CSC3H3_RS13645	COG0583	DNA-binding transcription factor activity
CSC3H3_RS13650	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS13655	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS13695	COG1522	sequence-specific DNA binding
CSC3H3_RS13730	COG5487	UPF0391 membrane protein
CSC3H3_RS13745	COG0602	queuosine metabolic process
CSC3H3_RS13750	COG0720	synthase
CSC3H3_RS13760	COG2226	methyltransferase
CSC3H3_RS13775	COG0601	transmembrane transport
CSC3H3_RS13780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSC3H3_RS13785	COG0444	Belongs to the ABC transporter superfamily
CSC3H3_RS13795	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CSC3H3_RS13810	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CSC3H3_RS13815	COG0583	DNA-binding transcription factor activity
CSC3H3_RS13825	COG0504	CTP synthase activity
CSC3H3_RS13845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CSC3H3_RS13850	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CSC3H3_RS13855	COG0047	phosphoribosylformylglycinamidine synthase activity
CSC3H3_RS13860	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CSC3H3_RS13865	COG0583	DNA-binding transcription factor activity
CSC3H3_RS13870	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS13875	COG0489	protein tyrosine kinase activity
CSC3H3_RS13880	COG0330	HflC and HflK could
CSC3H3_RS13885	COG0330	HflC and HflK could
CSC3H3_RS13895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CSC3H3_RS13900	COG0560	Phosphoserine phosphatase
CSC3H3_RS13900	COG3830	Belongs to the UPF0237 family
CSC3H3_RS13915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CSC3H3_RS13920	COG0028	Belongs to the TPP enzyme family
CSC3H3_RS13925	COG0440	acetolactate synthase activity
CSC3H3_RS13930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CSC3H3_RS13935	COG2814	Major facilitator Superfamily
CSC3H3_RS13940	COG0583	DNA-binding transcription factor activity
CSC3H3_RS13960	COG0415	Belongs to the DNA photolyase family
CSC3H3_RS13965	COG3025	triphosphatase activity
CSC3H3_RS13975	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CSC3H3_RS13980	COG1530	ribonuclease E activity
CSC3H3_RS14005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CSC3H3_RS14015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CSC3H3_RS14065	COG2197	response regulator
CSC3H3_RS14075	COG0604	alcohol dehydrogenase
CSC3H3_RS14080	COG3339	Conserved Protein
CSC3H3_RS14110	COG0354	folic acid binding
CSC3H3_RS14115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CSC3H3_RS14115	COG0574	Belongs to the PEP-utilizing enzyme family
CSC3H3_RS14125	COG0752	glycyl-tRNA synthetase alpha subunit
CSC3H3_RS14140	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CSC3H3_RS14150	COG0142	geranyltranstransferase activity
CSC3H3_RS14175	COG3474	cytochrome
CSC3H3_RS14185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CSC3H3_RS14215	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CSC3H3_RS14220	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CSC3H3_RS14225	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS14235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CSC3H3_RS14260	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CSC3H3_RS14265	COG0343	queuine tRNA-ribosyltransferase activity
CSC3H3_RS14270	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CSC3H3_RS14275	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CSC3H3_RS14280	COG0306	phosphate transporter
CSC3H3_RS14300	COG1733	regulation of RNA biosynthetic process
CSC3H3_RS14305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CSC3H3_RS14335	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CSC3H3_RS14350	COG0277	FAD linked oxidase domain protein
CSC3H3_RS14355	COG3119	arylsulfatase activity
CSC3H3_RS14370	COG2378	regulation of single-species biofilm formation
CSC3H3_RS14380	COG0559	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS14385	COG0069	glutamate synthase activity
CSC3H3_RS14430	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CSC3H3_RS14435	COG0488	(ABC) transporter
CSC3H3_RS14445	COG3023	N-Acetylmuramoyl-L-alanine amidase
CSC3H3_RS14465	COG1335	isochorismatase
CSC3H3_RS14470	COG2207	Transcriptional regulator
CSC3H3_RS14490	COG2001	Belongs to the MraZ family
CSC3H3_RS14495	COG0275	rRNA processing
CSC3H3_RS14510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CSC3H3_RS14540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CSC3H3_RS14550	COG1181	Belongs to the D-alanine--D-alanine ligase family
CSC3H3_RS14570	COG3842	ATPase activity
CSC3H3_RS14580	COG1175	transmembrane transport
CSC3H3_RS14585	COG1653	transport
CSC3H3_RS14590	COG0849	cell division
CSC3H3_RS14605	COG0583	DNA-binding transcription factor activity
CSC3H3_RS14610	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CSC3H3_RS14630	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CSC3H3_RS14635	COG0497	DNA recombination
CSC3H3_RS14640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CSC3H3_RS14655	COG0697	spore germination
CSC3H3_RS14665	COG0667	Aldo Keto reductase
CSC3H3_RS14670	COG0583	DNA-binding transcription factor activity
CSC3H3_RS14715	COG0006	proline dipeptidase activity
CSC3H3_RS14725	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS14730	COG2264	protein methyltransferase activity
CSC3H3_RS14735	COG0210	DNA helicase
CSC3H3_RS14745	COG3188	usher protein
CSC3H3_RS14770	COG2814	Major facilitator Superfamily
CSC3H3_RS14795	COG4191	Histidine kinase
CSC3H3_RS14795	COG0784	Response regulator, receiver
CSC3H3_RS14800	COG2201	protein-glutamate methylesterase activity
CSC3H3_RS14810	COG0646	methionine synthase
CSC3H3_RS14810	COG1410	methionine synthase
CSC3H3_RS14820	COG2226	methyltransferase
CSC3H3_RS14825	COG2853	Lipoprotein
CSC3H3_RS14845	COG0488	(ABC) transporter
CSC3H3_RS14860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CSC3H3_RS14865	COG0516	GMP reductase activity
CSC3H3_RS14865	COG0517	IMP dehydrogenase activity
CSC3H3_RS14880	COG1063	alcohol dehydrogenase
CSC3H3_RS14890	COG0725	ABC transporter, periplasmic molybdate-binding protein
CSC3H3_RS14895	COG4149	molybdate abc transporter
CSC3H3_RS14900	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CSC3H3_RS14910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CSC3H3_RS14915	COG0583	DNA-binding transcription factor activity
CSC3H3_RS14940	COG3842	ATPase activity
CSC3H3_RS14945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CSC3H3_RS14950	COG0395	ABC-type sugar transport system, permease component
CSC3H3_RS14970	COG1349	DNA-binding transcription factor activity
CSC3H3_RS14980	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS15000	COG1309	transcriptional regulator
CSC3H3_RS15015	COG0745	RESPONSE REGULATOR receiver
CSC3H3_RS15020	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CSC3H3_RS15040	COG0583	DNA-binding transcription factor activity
CSC3H3_RS15055	COG4774	siderophore transport
CSC3H3_RS15060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CSC3H3_RS15065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CSC3H3_RS15070	COG1120	ATPase activity
CSC3H3_RS15075	COG1132	(ABC) transporter
CSC3H3_RS15080	COG1473	amidohydrolase
CSC3H3_RS15095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CSC3H3_RS15115	COG0505	Belongs to the CarA family
CSC3H3_RS15120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CSC3H3_RS15125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CSC3H3_RS15130	COG1522	sequence-specific DNA binding
CSC3H3_RS15135	COG0492	ferredoxin-NADP+ reductase activity
CSC3H3_RS15140	COG0583	DNA-binding transcription factor activity
CSC3H3_RS15145	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CSC3H3_RS15155	COG2932	Transcriptional regulator
CSC3H3_RS15165	COG1475	DNA binding
CSC3H3_RS15175	COG2801	Transposase and inactivated derivatives
CSC3H3_RS15180	COG2842	Transposition protein
CSC3H3_RS15270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CSC3H3_RS15290	COG4373	Mu-like prophage FluMu protein gp28
CSC3H3_RS15295	COG4383	Mu-like prophage protein gp29
CSC3H3_RS15310	COG4388	Caudovirus prohead serine protease
CSC3H3_RS15410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CSC3H3_RS15415	COG0783	Belongs to the Dps family
CSC3H3_RS15420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CSC3H3_RS15430	COG0556	nucleotide-excision repair
CSC3H3_RS15435	COG0436	Aminotransferase
CSC3H3_RS15445	COG0367	asparagine synthase
CSC3H3_RS15450	COG0463	Glycosyl transferase, family 2
CSC3H3_RS15460	COG0450	alkyl hydroperoxide reductase
CSC3H3_RS15465	COG0583	DNA-binding transcription factor activity
CSC3H3_RS15485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CSC3H3_RS15485	COG0519	Catalyzes the synthesis of GMP from XMP
CSC3H3_RS15490	COG0012	GTP binding
CSC3H3_RS15500	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CSC3H3_RS15505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CSC3H3_RS15560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CSC3H3_RS15590	COG0745	RESPONSE REGULATOR receiver
CSC3H3_RS15595	COG1846	Transcriptional regulator
CSC3H3_RS15600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CSC3H3_RS15605	COG2249	NAD(P)H dehydrogenase (quinone) activity
CSC3H3_RS15610	COG2207	Transcriptional regulator
CSC3H3_RS15615	COG0372	Belongs to the citrate synthase family
CSC3H3_RS15620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CSC3H3_RS15625	COG0408	coproporphyrinogen oxidase activity
CSC3H3_RS15630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CSC3H3_RS15650	COG1280	lysine exporter protein (LysE YggA)
CSC3H3_RS15665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CSC3H3_RS15690	COG0572	uridine kinase
CSC3H3_RS15700	COG1335	isochorismatase
CSC3H3_RS15710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CSC3H3_RS15715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CSC3H3_RS15720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CSC3H3_RS15735	COG0789	Transcriptional regulator
CSC3H3_RS15745	COG2376	Dihydroxyacetone kinase
CSC3H3_RS15750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CSC3H3_RS15765	COG3181	Tripartite tricarboxylate transporter family receptor
CSC3H3_RS15785	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CSC3H3_RS15790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CSC3H3_RS15875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CSC3H3_RS15880	COG1360	Flagellar Motor Protein
CSC3H3_RS15890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CSC3H3_RS15915	COG1473	amidohydrolase
CSC3H3_RS15925	COG0612	Peptidase, M16
CSC3H3_RS15930	COG0612	Peptidase, M16
CSC3H3_RS15950	COG0196	riboflavin kinase activity
CSC3H3_RS15955	COG2030	dehydratase
CSC3H3_RS15960	COG2226	methyltransferase
CSC3H3_RS16010	COG0737	Belongs to the 5'-nucleotidase family
CSC3H3_RS16020	COG2207	Transcriptional regulator
CSC3H3_RS16040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CSC3H3_RS16045	COG1940	carbohydrate kinase activity
CSC3H3_RS16050	COG1069	ribulokinase activity
CSC3H3_RS16055	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS16075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CSC3H3_RS16080	COG1960	acyl-CoA dehydrogenase activity
CSC3H3_RS16085	COG0583	DNA-binding transcription factor activity
CSC3H3_RS16115	COG0583	DNA-binding transcription factor activity
CSC3H3_RS16145	COG0501	Belongs to the peptidase M48B family
CSC3H3_RS16180	COG4251	negative regulation of phosphorylation
CSC3H3_RS16190	COG0583	DNA-binding transcription factor activity
CSC3H3_RS16195	COG2814	Major facilitator Superfamily
CSC3H3_RS16200	COG2832	Protein of unknown function (DUF454)
CSC3H3_RS16220	COG0583	DNA-binding transcription factor activity
CSC3H3_RS16235	COG1320	monovalent cation:proton antiporter activity
CSC3H3_RS16240	COG2212	antiporter activity
CSC3H3_RS16245	COG1863	multisubunit Na H antiporter MnhE subunit
CSC3H3_RS16250	COG0651	ATP synthesis coupled electron transport
CSC3H3_RS16255	COG1006	Multisubunit Na H antiporter MnhC subunit
CSC3H3_RS16260	COG2111	Na H antiporter
CSC3H3_RS16260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CSC3H3_RS16265	COG2814	Major facilitator Superfamily
CSC3H3_RS16270	COG0626	cystathionine gamma-synthase activity
CSC3H3_RS16275	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CSC3H3_RS16315	COG5001	Diguanylate cyclase
CSC3H3_RS16315	COG3300	MHYT domain
CSC3H3_RS16320	COG0733	neurotransmitter:sodium symporter activity
CSC3H3_RS16335	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CSC3H3_RS16340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CSC3H3_RS16350	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CSC3H3_RS16355	COG1138	Cytochrome C-type biogenesis protein
CSC3H3_RS16360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CSC3H3_RS16365	COG3088	subunit of a heme lyase
CSC3H3_RS16370	COG4235	cytochrome complex assembly
CSC3H3_RS16370	COG3088	subunit of a heme lyase
CSC3H3_RS16395	COG1012	belongs to the aldehyde dehydrogenase family
CSC3H3_RS16420	COG1473	amidohydrolase
CSC3H3_RS16450	COG3142	Participates in the control of copper homeostasis
CSC3H3_RS16455	COG1940	carbohydrate kinase activity
CSC3H3_RS16465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CSC3H3_RS16470	COG1446	asparaginase
CSC3H3_RS16475	COG1126	abc transporter atp-binding protein
CSC3H3_RS16480	COG0765	amino acid transport
CSC3H3_RS16485	COG0765	amino acid transport
CSC3H3_RS16500	COG0612	Peptidase, M16
CSC3H3_RS16510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CSC3H3_RS16515	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CSC3H3_RS16530	COG1845	cytochrome c oxidase, subunit III
CSC3H3_RS16540	COG0109	protoheme IX farnesyltransferase activity
CSC3H3_RS16545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CSC3H3_RS16550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CSC3H3_RS16575	COG0604	alcohol dehydrogenase
CSC3H3_RS16585	COG2814	Major facilitator Superfamily
CSC3H3_RS16590	COG0583	DNA-binding transcription factor activity
CSC3H3_RS16595	COG1309	transcriptional regulator
CSC3H3_RS16605	COG1678	Uncharacterized ACR, COG1678
CSC3H3_RS16615	COG0678	peroxiredoxin activity
CSC3H3_RS16630	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CSC3H3_RS16635	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CSC3H3_RS16640	COG0509	glycine decarboxylation via glycine cleavage system
CSC3H3_RS16645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CSC3H3_RS16655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CSC3H3_RS16665	COG0328	RNA-DNA hybrid ribonuclease activity
CSC3H3_RS16680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CSC3H3_RS16680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CSC3H3_RS16685	COG0604	alcohol dehydrogenase
CSC3H3_RS16710	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CSC3H3_RS16740	COG2096	Adenosyltransferase
CSC3H3_RS16755	COG1250	3-hydroxyacyl-CoA dehydrogenase
CSC3H3_RS16760	COG1070	Carbohydrate kinase
CSC3H3_RS16765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CSC3H3_RS16770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CSC3H3_RS16775	COG0165	Argininosuccinate lyase
CSC3H3_RS16780	COG0019	diaminopimelate decarboxylase activity
CSC3H3_RS16795	COG2884	Cell division ATP-binding protein ftsE
CSC3H3_RS16830	COG0287	Prephenate dehydrogenase
CSC3H3_RS16845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CSC3H3_RS16850	COG2813	Specifically methylates the guanine in position
CSC3H3_RS16850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CSC3H3_RS16865	COG0314	molybdopterin synthase activity
CSC3H3_RS16870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CSC3H3_RS16875	COG2233	PERMEase
CSC3H3_RS16910	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS16930	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CSC3H3_RS16950	COG0745	RESPONSE REGULATOR receiver
CSC3H3_RS16965	COG0581	inorganic phosphate transmembrane transporter activity
CSC3H3_RS16970	COG0573	inorganic phosphate transmembrane transporter activity
CSC3H3_RS16975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CSC3H3_RS16985	COG0247	lactate metabolic process
CSC3H3_RS16990	COG0277	FAD linked oxidase domain protein
CSC3H3_RS16995	COG0277	FAD linked oxidase domain protein
CSC3H3_RS17000	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CSC3H3_RS17015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CSC3H3_RS17035	COG0747	negative chemotaxis
CSC3H3_RS17065	COG1968	undecaprenyl-diphosphatase activity
CSC3H3_RS17070	COG0640	Transcriptional regulator
CSC3H3_RS17080	COG0740	serine-type endopeptidase activity
CSC3H3_RS17110	COG0778	Nitroreductase
CSC3H3_RS17125	COG1058	Belongs to the CinA family
CSC3H3_RS17125	COG1546	Belongs to the CinA family
CSC3H3_RS17140	COG0159	tryptophan synthase activity
CSC3H3_RS17170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CSC3H3_RS17175	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CSC3H3_RS17185	COG1639	'signal transduction protein
CSC3H3_RS17200	COG1742	UPF0060 membrane protein
CSC3H3_RS17215	COG1522	sequence-specific DNA binding
CSC3H3_RS17220	COG3186	Phenylalanine-4-hydroxylase
CSC3H3_RS17240	COG2814	Major facilitator Superfamily
CSC3H3_RS17260	COG1703	isobutyryl-CoA mutase activity
CSC3H3_RS17270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CSC3H3_RS17375	COG0501	Belongs to the peptidase M48B family
CSC3H3_RS17380	COG2095	MarC family integral membrane protein
CSC3H3_RS17410	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS17415	COG5642	Protein of unknown function (DUF2384)
CSC3H3_RS17425	COG0583	DNA-binding transcription factor activity
CSC3H3_RS17430	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CSC3H3_RS17440	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CSC3H3_RS17445	COG1122	ATPase activity
CSC3H3_RS17450	COG1268	BioY protein
CSC3H3_RS17465	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CSC3H3_RS17470	COG0830	nickel cation binding
CSC3H3_RS17475	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CSC3H3_RS17480	COG0804	urea catabolic process
CSC3H3_RS17485	COG0832	Belongs to the urease beta subunit family
CSC3H3_RS17490	COG0831	urea catabolic process
CSC3H3_RS17495	COG0829	nickel cation binding
CSC3H3_RS17505	COG0411	ABC transporter
CSC3H3_RS17515	COG0559	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS17545	COG0583	DNA-binding transcription factor activity
CSC3H3_RS17555	COG1346	cytolysis
CSC3H3_RS17560	COG1380	Effector of murein hydrolase LrgA
CSC3H3_RS17565	COG0583	DNA-binding transcription factor activity
CSC3H3_RS17580	COG0840	transmembrane signaling receptor activity
CSC3H3_RS17595	COG1079	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS17605	COG3845	ABC transporter
CSC3H3_RS17610	COG0590	tRNA wobble adenosine to inosine editing
CSC3H3_RS17620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CSC3H3_RS17625	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CSC3H3_RS17645	COG4266	Belongs to the allantoicase family
CSC3H3_RS17650	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CSC3H3_RS17665	COG1733	regulation of RNA biosynthetic process
CSC3H3_RS17675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CSC3H3_RS17685	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CSC3H3_RS17695	COG2030	dehydratase
CSC3H3_RS17700	COG2301	Belongs to the HpcH HpaI aldolase family
CSC3H3_RS17705	COG2885	chlorophyll binding
CSC3H3_RS17720	COG1566	PFAM secretion protein HlyD family protein
CSC3H3_RS17740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CSC3H3_RS17775	COG1842	Phage shock protein A
CSC3H3_RS17780	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CSC3H3_RS17795	COG1960	acyl-CoA dehydrogenase activity
CSC3H3_RS17800	COG0288	reversible hydration of carbon dioxide
CSC3H3_RS17805	COG0183	Belongs to the thiolase family
CSC3H3_RS17810	COG1960	acyl-CoA dehydrogenase activity
CSC3H3_RS17830	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSC3H3_RS17840	COG0513	Belongs to the DEAD box helicase family
CSC3H3_RS17855	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CSC3H3_RS17860	COG3474	cytochrome
CSC3H3_RS17890	COG4221	oxidoreductase activity
CSC3H3_RS17910	COG1522	sequence-specific DNA binding
CSC3H3_RS17930	COG2154	pterin-4-alpha-carbinolamine dehydratase
CSC3H3_RS17945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CSC3H3_RS17965	COG4172	Belongs to the ABC transporter superfamily
CSC3H3_RS17970	COG4239	(ABC) transporter, permease
CSC3H3_RS17975	COG4174	ABC transporter (Permease)
CSC3H3_RS17980	COG4166	transmembrane transport
CSC3H3_RS17985	COG0583	DNA-binding transcription factor activity
CSC3H3_RS18040	COG0693	protein deglycase activity
CSC3H3_RS18045	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CSC3H3_RS18050	COG1741	Belongs to the pirin family
CSC3H3_RS18055	COG0667	Aldo Keto reductase
CSC3H3_RS18085	COG4181	ATPase activity
CSC3H3_RS18090	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CSC3H3_RS18095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CSC3H3_RS18105	COG0670	Belongs to the BI1 family
CSC3H3_RS18115	COG0501	Belongs to the peptidase M48B family
CSC3H3_RS18120	COG2902	Dehydrogenase
CSC3H3_RS18125	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CSC3H3_RS18135	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS18140	COG5001	Diguanylate cyclase
CSC3H3_RS18160	COG3118	belongs to the thioredoxin family
CSC3H3_RS18170	COG2835	tetraacyldisaccharide 4'-kinase activity
CSC3H3_RS18180	COG3047	cAMP biosynthetic process
CSC3H3_RS18185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CSC3H3_RS18190	COG0347	Belongs to the P(II) protein family
CSC3H3_RS18195	COG0004	ammonium transporteR
CSC3H3_RS18200	COG0004	ammonium transporteR
CSC3H3_RS18210	COG1674	ftsk spoiiie
CSC3H3_RS18215	COG3069	C4-dicarboxylate transmembrane transporter activity
CSC3H3_RS18220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CSC3H3_RS18250	COG1074	ATP-dependent DNA helicase activity
CSC3H3_RS18255	COG2887	Belongs to the helicase family. UvrD subfamily
CSC3H3_RS18265	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CSC3H3_RS18275	COG0802	atpase or kinase
CSC3H3_RS18290	COG4702	Belongs to the UPF0303 family
CSC3H3_RS18300	COG4251	negative regulation of phosphorylation
CSC3H3_RS18325	COG0072	phenylalanine-tRNA ligase activity
CSC3H3_RS18330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CSC3H3_RS18335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CSC3H3_RS18340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CSC3H3_RS18345	COG0745	RESPONSE REGULATOR receiver
CSC3H3_RS18350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CSC3H3_RS18355	COG0859	PFAM glycosyl transferase family 9
CSC3H3_RS18390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CSC3H3_RS18400	COG0181	hydroxymethylbilane synthase activity
CSC3H3_RS18420	COG0138	bifunctional purine biosynthesis protein purh
CSC3H3_RS18430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CSC3H3_RS18460	COG2183	response to ionizing radiation
CSC3H3_RS18470	COG0352	thiamine-phosphate diphosphorylase activity
CSC3H3_RS18480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CSC3H3_RS18495	COG1012	belongs to the aldehyde dehydrogenase family
CSC3H3_RS18500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CSC3H3_RS18515	COG0583	DNA-binding transcription factor activity
CSC3H3_RS18520	COG0840	transmembrane signaling receptor activity
CSC3H3_RS18525	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CSC3H3_RS18530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CSC3H3_RS18535	COG4558	Periplasmic binding protein
CSC3H3_RS18540	COG2807	transmembrane transport
CSC3H3_RS18560	COG0583	DNA-binding transcription factor activity
CSC3H3_RS18580	COG2067	long-chain fatty acid transport protein
CSC3H3_RS18585	COG0318	PFAM AMP-dependent synthetase and ligase
CSC3H3_RS18590	COG0789	Transcriptional regulator
CSC3H3_RS18595	COG0183	Belongs to the thiolase family
CSC3H3_RS18600	COG1250	3-hydroxyacyl-CoA dehydrogenase
CSC3H3_RS18600	COG1024	Enoyl-CoA hydratase
CSC3H3_RS18605	COG1960	acyl-CoA dehydrogenase activity
CSC3H3_RS18615	COG1024	Enoyl-CoA hydratase
CSC3H3_RS18620	COG0300	oxidoreductase activity
CSC3H3_RS18630	COG2943	transferase activity, transferring hexosyl groups
CSC3H3_RS18645	COG4208	sulfate ABC transporter
CSC3H3_RS18660	COG3842	ATPase activity
CSC3H3_RS18690	COG0730	response to heat
CSC3H3_RS18695	COG2188	Transcriptional regulator
CSC3H3_RS18740	COG1595	DNA-templated transcription, initiation
CSC3H3_RS18750	COG1741	Belongs to the pirin family
CSC3H3_RS18755	COG2259	Doxx family
CSC3H3_RS18765	COG2207	Transcriptional regulator
CSC3H3_RS18765	COG4753	response regulator
CSC3H3_RS18770	COG4191	Histidine kinase
CSC3H3_RS18780	COG2200	EAL domain
CSC3H3_RS18785	COG2201	protein-glutamate methylesterase activity
CSC3H3_RS18850	COG3180	Ammonia monooxygenase
CSC3H3_RS18855	COG1228	amidohydrolase
CSC3H3_RS18860	COG2986	histidine ammonia-lyase
CSC3H3_RS18865	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CSC3H3_RS18870	COG2188	Transcriptional regulator
CSC3H3_RS18885	COG0297	glycogen (starch) synthase activity
CSC3H3_RS18910	COG2226	methyltransferase
CSC3H3_RS18910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CSC3H3_RS18910	COG0596	Alpha beta hydrolase
CSC3H3_RS18925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CSC3H3_RS18935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CSC3H3_RS18945	COG3206	protein involved in exopolysaccharide biosynthesis
CSC3H3_RS18945	COG0489	protein tyrosine kinase activity
CSC3H3_RS18970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CSC3H3_RS18980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CSC3H3_RS18985	COG3181	Tripartite tricarboxylate transporter family receptor
CSC3H3_RS19010	COG2186	Transcriptional regulator
CSC3H3_RS19015	COG0028	Belongs to the TPP enzyme family
CSC3H3_RS19020	COG1216	Glycosyl transferase, family 2
CSC3H3_RS19035	COG1216	Glycosyl transferase, family 2
CSC3H3_RS19040	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CSC3H3_RS19050	COG1215	transferase activity, transferring glycosyl groups
CSC3H3_RS19065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CSC3H3_RS19085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CSC3H3_RS19090	COG1132	(ABC) transporter
CSC3H3_RS19100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CSC3H3_RS19110	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CSC3H3_RS19110	COG0662	Cupin 2, conserved barrel domain protein
CSC3H3_RS19130	COG1131	(ABC) transporter
CSC3H3_RS19140	COG0133	tryptophan synthase activity
CSC3H3_RS19150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CSC3H3_RS19155	COG0285	dihydrofolate synthase activity
CSC3H3_RS19165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CSC3H3_RS19165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CSC3H3_RS19180	COG0667	Aldo Keto reductase
CSC3H3_RS19185	COG0583	DNA-binding transcription factor activity
CSC3H3_RS19195	COG0492	ferredoxin-NADP+ reductase activity
CSC3H3_RS19215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CSC3H3_RS19225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CSC3H3_RS19230	COG0792	nuclease activity
CSC3H3_RS19245	COG0667	Aldo Keto reductase
CSC3H3_RS19260	COG2814	Major facilitator Superfamily
CSC3H3_RS19270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CSC3H3_RS19275	COG1217	gtp-binding protein TYPA
CSC3H3_RS19280	COG2211	Major facilitator Superfamily
CSC3H3_RS19285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CSC3H3_RS19290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CSC3H3_RS19295	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CSC3H3_RS19300	COG1137	ATPase activity
CSC3H3_RS19340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CSC3H3_RS19345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CSC3H3_RS19350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CSC3H3_RS19360	COG1420	regulation of RNA biosynthetic process
CSC3H3_RS19365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CSC3H3_RS19380	COG0697	spore germination
CSC3H3_RS19405	COG0583	DNA-binding transcription factor activity
CSC3H3_RS19410	COG1216	Glycosyl transferase, family 2
CSC3H3_RS19415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CSC3H3_RS19430	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CSC3H3_RS19435	COG2992	FlgJ-related protein
CSC3H3_RS19445	COG0280	phosphate acetyltransferase
CSC3H3_RS19445	COG0281	malic enzyme
CSC3H3_RS19470	COG0180	Tryptophanyl-tRNA synthetase
CSC3H3_RS19485	COG0745	RESPONSE REGULATOR receiver
CSC3H3_RS19505	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CSC3H3_RS19550	COG0445	tRNA wobble uridine modification
CSC3H3_RS19555	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CSC3H3_RS19570	COG1331	Highly conserved protein containing a thioredoxin domain
CSC3H3_RS19575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CSC3H3_RS19580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CSC3H3_RS19595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CSC3H3_RS19615	COG1139	Iron-sulfur cluster binding protein
CSC3H3_RS19620	COG0247	lactate metabolic process
CSC3H3_RS19630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CSC3H3_RS19635	COG0237	dephospho-CoA kinase activity
CSC3H3_RS19640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CSC3H3_RS19645	COG0424	maF-like protein
CSC3H3_RS19650	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CSC3H3_RS19665	COG1981	membrane
CSC3H3_RS19670	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CSC3H3_RS19675	COG3030	protein affecting phage T7 exclusion by the F plasmid
CSC3H3_RS19705	COG0667	Aldo Keto reductase
CSC3H3_RS19740	COG0189	ligase activity
CSC3H3_RS19760	COG0606	chelatase, subunit chli
CSC3H3_RS19780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CSC3H3_RS19815	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CSC3H3_RS19825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CSC3H3_RS19845	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CSC3H3_RS19850	COG0656	L-ascorbic acid biosynthetic process
CSC3H3_RS19860	COG5002	protein histidine kinase activity
CSC3H3_RS19875	COG0726	polysaccharide deacetylase
CSC3H3_RS19875	COG1649	PFAM Uncharacterised BCR, COG1649
CSC3H3_RS19880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CSC3H3_RS19885	COG0756	dUTP diphosphatase activity
CSC3H3_RS19890	COG1959	2 iron, 2 sulfur cluster binding
CSC3H3_RS19895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CSC3H3_RS19915	COG1280	lysine exporter protein (LysE YggA)
CSC3H3_RS19930	COG0251	oxidation-reduction process
CSC3H3_RS19945	COG1214	PFAM Peptidase M22, glycoprotease
CSC3H3_RS19980	COG1702	phosphate starvation-inducible protein PhoH
CSC3H3_RS19990	COG1253	flavin adenine dinucleotide binding
CSC3H3_RS19995	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CSC3H3_RS20000	COG1396	sequence-specific DNA binding
CSC3H3_RS20005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CSC3H3_RS20010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CSC3H3_RS20015	COG1595	DNA-templated transcription, initiation
CSC3H3_RS20025	COG1629	transport
CSC3H3_RS20025	COG4206	TonB-dependent receptor
CSC3H3_RS20035	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
CSC3H3_RS20065	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CSC3H3_RS20080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CSC3H3_RS20090	COG1185	polyribonucleotide nucleotidyltransferase activity
CSC3H3_RS20105	COG1592	Rubrerythrin
CSC3H3_RS20115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CSC3H3_RS20140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CSC3H3_RS20145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CSC3H3_RS20150	COG1268	BioY protein
CSC3H3_RS20175	COG2308	Evidence 4 Homologs of previously reported genes of
CSC3H3_RS20180	COG2875	Belongs to the precorrin methyltransferase family
CSC3H3_RS20205	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CSC3H3_RS20210	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CSC3H3_RS20240	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CSC3H3_RS20285	COG1492	cobalamin metabolic process
CSC3H3_RS20295	COG2813	Specifically methylates the guanine in position
CSC3H3_RS20315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CSC3H3_RS20330	COG0583	DNA-binding transcription factor activity
CSC3H3_RS20340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CSC3H3_RS20345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSC3H3_RS20355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS20365	COG2099	Precorrin-6x reductase
CSC3H3_RS20390	COG1999	signal sequence binding
CSC3H3_RS20395	COG1797	cobyrinic acid a,c-diamide synthase activity
CSC3H3_RS20400	COG2983	Belongs to the UPF0260 family
CSC3H3_RS20415	COG0071	Belongs to the small heat shock protein (HSP20) family
CSC3H3_RS20425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CSC3H3_RS20425	COG0519	Catalyzes the synthesis of GMP from XMP
CSC3H3_RS20445	COG0672	)-iron permease
CSC3H3_RS20450	COG4633	Protein conserved in bacteria
CSC3H3_RS20510	COG0539	negative regulation of cytoplasmic translation
CSC3H3_RS20515	COG0616	signal peptide processing
CSC3H3_RS20520	COG0776	regulation of translation
CSC3H3_RS20545	COG2814	Major facilitator Superfamily
CSC3H3_RS20550	COG0730	response to heat
CSC3H3_RS20560	COG1024	Enoyl-CoA hydratase
CSC3H3_RS20565	COG0268	Binds directly to 16S ribosomal RNA
CSC3H3_RS20575	COG4962	Type ii secretion system protein e
CSC3H3_RS20645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CSC3H3_RS20675	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CSC3H3_RS20680	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CSC3H3_RS20685	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CSC3H3_RS20690	COG2205	protein histidine kinase activity
CSC3H3_RS20750	COG1070	Carbohydrate kinase
CSC3H3_RS20785	COG3347	Dehydrogenase
CSC3H3_RS20785	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS20790	COG1802	Transcriptional regulator
CSC3H3_RS20795	COG1063	alcohol dehydrogenase
CSC3H3_RS20800	COG0246	Mannitol dehydrogenase
CSC3H3_RS20805	COG2721	sulfolactate sulfo-lyase activity
CSC3H3_RS20810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSC3H3_RS20815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CSC3H3_RS20820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS20840	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS20850	COG0473	3-isopropylmalate dehydrogenase activity
CSC3H3_RS20850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CSC3H3_RS20860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CSC3H3_RS20875	COG3181	Tripartite tricarboxylate transporter family receptor
CSC3H3_RS20895	COG1175	transmembrane transport
CSC3H3_RS20905	COG3842	ATPase activity
CSC3H3_RS20915	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CSC3H3_RS20920	COG0456	acetyltransferase
CSC3H3_RS20935	COG1522	sequence-specific DNA binding
CSC3H3_RS20960	COG2197	response regulator
CSC3H3_RS20965	COG2197	response regulator
CSC3H3_RS20970	COG2197	response regulator
CSC3H3_RS20985	COG0587	DNA-directed DNA polymerase activity
CSC3H3_RS21005	COG0747	negative chemotaxis
CSC3H3_RS21015	COG0405	Gamma-glutamyltransferase
CSC3H3_RS21020	COG0601	transmembrane transport
CSC3H3_RS21025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSC3H3_RS21030	COG0444	Belongs to the ABC transporter superfamily
CSC3H3_RS21035	COG4608	Belongs to the ABC transporter superfamily
CSC3H3_RS21045	COG1472	Belongs to the glycosyl hydrolase 3 family
CSC3H3_RS21055	COG0601	transmembrane transport
CSC3H3_RS21060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSC3H3_RS21065	COG0444	Belongs to the ABC transporter superfamily
CSC3H3_RS21080	COG1921	L-seryl-tRNASec selenium transferase activity
CSC3H3_RS21105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CSC3H3_RS21120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CSC3H3_RS21125	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CSC3H3_RS21195	COG2030	dehydratase
CSC3H3_RS21200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CSC3H3_RS21210	COG0165	Argininosuccinate lyase
CSC3H3_RS21230	COG1940	carbohydrate kinase activity
CSC3H3_RS21245	COG4948	Mandelate Racemase Muconate Lactonizing
CSC3H3_RS21255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CSC3H3_RS21260	COG3246	L-lysine catabolic process to acetate
CSC3H3_RS21265	COG2358	TRAP transporter, solute receptor (TAXI family
CSC3H3_RS21320	COG1215	transferase activity, transferring glycosyl groups
CSC3H3_RS21325	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CSC3H3_RS21360	COG1250	3-hydroxyacyl-CoA dehydrogenase
CSC3H3_RS21360	COG1024	Enoyl-CoA hydratase
CSC3H3_RS21365	COG1960	acyl-CoA dehydrogenase activity
CSC3H3_RS21380	COG3483	tryptophan 2,3-dioxygenase activity
CSC3H3_RS21395	COG0300	oxidoreductase activity
CSC3H3_RS21400	COG0583	DNA-binding transcription factor activity
CSC3H3_RS21405	COG0583	DNA-binding transcription factor activity
CSC3H3_RS21415	COG4172	Belongs to the ABC transporter superfamily
CSC3H3_RS21420	COG0747	negative chemotaxis
CSC3H3_RS21425	COG0601	transmembrane transport
CSC3H3_RS21430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSC3H3_RS21440	COG2362	D-Aminopeptidase
CSC3H3_RS21450	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CSC3H3_RS21455	COG0395	ABC-type sugar transport system, permease component
CSC3H3_RS21470	COG1609	Transcriptional regulator
CSC3H3_RS21475	COG2030	dehydratase
CSC3H3_RS21485	COG3254	rhamnose metabolic process
CSC3H3_RS21500	COG3618	amidohydrolase
CSC3H3_RS21520	COG0596	Alpha beta hydrolase
CSC3H3_RS21530	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CSC3H3_RS21595	COG3829	transcription factor binding
CSC3H3_RS21685	COG0457	Tetratricopeptide repeat
CSC3H3_RS21695	COG2207	Transcriptional regulator
CSC3H3_RS21715	COG0673	inositol 2-dehydrogenase activity
CSC3H3_RS21725	COG3718	enzyme involved in inositol metabolism
CSC3H3_RS21735	COG3962	Belongs to the TPP enzyme family
CSC3H3_RS21740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CSC3H3_RS21795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSC3H3_RS21800	COG0625	glutathione transferase activity
CSC3H3_RS21815	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CSC3H3_RS21825	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CSC3H3_RS21850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CSC3H3_RS21850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS21855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS21855	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CSC3H3_RS21860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSC3H3_RS21870	COG1802	Transcriptional regulator
CSC3H3_RS21880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CSC3H3_RS21890	COG0039	L-malate dehydrogenase activity
CSC3H3_RS21900	COG0657	acetylesterase activity
CSC3H3_RS21910	COG4172	Belongs to the ABC transporter superfamily
CSC3H3_RS21915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSC3H3_RS21920	COG0601	transmembrane transport
CSC3H3_RS21935	COG0473	3-isopropylmalate dehydrogenase activity
CSC3H3_RS21940	COG2828	Protein conserved in bacteria
CSC3H3_RS21975	COG1802	Transcriptional regulator
CSC3H3_RS21985	COG0747	negative chemotaxis
CSC3H3_RS21995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSC3H3_RS22000	COG0444	Belongs to the ABC transporter superfamily
CSC3H3_RS22005	COG4608	Belongs to the ABC transporter superfamily
CSC3H3_RS22010	COG0405	Gamma-glutamyltransferase
CSC3H3_RS22020	COG4948	Mandelate Racemase Muconate Lactonizing
CSC3H3_RS22025	COG1414	Transcriptional regulator
CSC3H3_RS22045	COG1175	transmembrane transport
CSC3H3_RS22050	COG0395	ABC-type sugar transport system, permease component
CSC3H3_RS22055	COG3842	ATPase activity
CSC3H3_RS22060	COG4948	Mandelate Racemase Muconate Lactonizing
CSC3H3_RS22070	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS22075	COG0179	Fumarylacetoacetate (FAA) hydrolase
CSC3H3_RS22090	COG1538	Outer membrane efflux protein
CSC3H3_RS22100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CSC3H3_RS22105	COG0745	RESPONSE REGULATOR receiver
CSC3H3_RS22110	COG2205	protein histidine kinase activity
CSC3H3_RS22135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CSC3H3_RS22145	COG2186	Transcriptional regulator
CSC3H3_RS22175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CSC3H3_RS22180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSC3H3_RS22195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CSC3H3_RS22215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CSC3H3_RS22230	COG1120	ATPase activity
CSC3H3_RS22245	COG3153	acetyltransferase
CSC3H3_RS22285	COG0826	peptidase U32
CSC3H3_RS22295	COG2124	cytochrome p450
CSC3H3_RS22315	COG1115	amino acid carrier protein
CSC3H3_RS22330	COG0493	'glutamate synthase
CSC3H3_RS22350	COG1309	transcriptional regulator
CSC3H3_RS22355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CSC3H3_RS22370	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CSC3H3_RS22375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CSC3H3_RS22380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CSC3H3_RS22405	COG0698	ribose 5-phosphate isomerase
CSC3H3_RS22410	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CSC3H3_RS22425	COG1172	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS22430	COG1129	ABC transporter
CSC3H3_RS22460	COG1349	DNA-binding transcription factor activity
CSC3H3_RS22465	COG5654	RES domain protein
CSC3H3_RS22505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CSC3H3_RS22515	COG0673	inositol 2-dehydrogenase activity
CSC3H3_RS22520	COG0438	transferase activity, transferring glycosyl groups
CSC3H3_RS22525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CSC3H3_RS22530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CSC3H3_RS22545	COG3938	Belongs to the proline racemase family
CSC3H3_RS22575	COG0235	Class ii aldolase
CSC3H3_RS22590	COG1172	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS22595	COG1172	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS22600	COG1129	ABC transporter
CSC3H3_RS22620	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CSC3H3_RS22625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CSC3H3_RS22630	COG0583	DNA-binding transcription factor activity
CSC3H3_RS22640	COG0626	cystathionine gamma-synthase activity
CSC3H3_RS22645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CSC3H3_RS22650	COG4597	amino acid ABC transporter
CSC3H3_RS22655	COG0765	amino acid transport
CSC3H3_RS22660	COG1126	abc transporter atp-binding protein
CSC3H3_RS22670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CSC3H3_RS22670	COG2169	Transcriptional regulator
CSC3H3_RS22680	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CSC3H3_RS22685	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CSC3H3_RS22720	COG0746	molybdenum cofactor guanylyltransferase activity
CSC3H3_RS22725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CSC3H3_RS22740	COG0129	dihydroxy-acid dehydratase activity
CSC3H3_RS22745	COG0604	alcohol dehydrogenase
CSC3H3_RS22750	COG0583	DNA-binding transcription factor activity
CSC3H3_RS22770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS22780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSC3H3_RS22790	COG2207	Transcriptional regulator
CSC3H3_RS22795	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS22800	COG2188	Transcriptional regulator
CSC3H3_RS22805	COG0114	fumarate hydratase activity
CSC3H3_RS22820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CSC3H3_RS22825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS22830	COG1011	Hydrolase
CSC3H3_RS22835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CSC3H3_RS22840	COG1301	dicarboxylic acid transport
CSC3H3_RS22845	COG0251	oxidation-reduction process
CSC3H3_RS22860	COG0252	asparaginase activity
CSC3H3_RS22865	COG1126	abc transporter atp-binding protein
CSC3H3_RS22870	COG0765	amino acid transport
CSC3H3_RS22875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CSC3H3_RS22890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CSC3H3_RS22895	COG1012	belongs to the aldehyde dehydrogenase family
CSC3H3_RS22915	COG1522	sequence-specific DNA binding
CSC3H3_RS22955	COG0028	Belongs to the TPP enzyme family
CSC3H3_RS22960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CSC3H3_RS22965	COG1653	transport
CSC3H3_RS22970	COG1175	transmembrane transport
CSC3H3_RS22980	COG3842	ATPase activity
CSC3H3_RS23010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CSC3H3_RS23010	COG0446	pyridine nucleotide-disulphide oxidoreductase
CSC3H3_RS23015	COG4311	Sarcosine oxidase, delta subunit
CSC3H3_RS23020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CSC3H3_RS23025	COG1027	Aspartate ammonia-lyase
CSC3H3_RS23045	COG0765	amino acid transport
CSC3H3_RS23170	COG0583	DNA-binding transcription factor activity
CSC3H3_RS23185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CSC3H3_RS23250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CSC3H3_RS23260	COG2207	Transcriptional regulator
CSC3H3_RS23270	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS23285	COG1172	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS23295	COG4948	Mandelate Racemase Muconate Lactonizing
CSC3H3_RS23305	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS23320	COG0583	DNA-binding transcription factor activity
CSC3H3_RS23355	COG3842	ATPase activity
CSC3H3_RS23360	COG3842	ATPase activity
CSC3H3_RS23370	COG0395	ABC-type sugar transport system, permease component
CSC3H3_RS23385	COG0840	transmembrane signaling receptor activity
CSC3H3_RS23410	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CSC3H3_RS23430	COG2188	Transcriptional regulator
CSC3H3_RS23455	COG2986	histidine ammonia-lyase
CSC3H3_RS23470	COG4977	sequence-specific DNA binding
CSC3H3_RS23505	COG0163	prenyltransferase activity
CSC3H3_RS23510	COG2207	Transcriptional regulator
CSC3H3_RS23520	COG2733	membrane
CSC3H3_RS23525	COG0246	Mannitol dehydrogenase
CSC3H3_RS23530	COG1312	Catalyzes the dehydration of D-mannonate
CSC3H3_RS23535	COG1802	Transcriptional regulator
CSC3H3_RS23540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CSC3H3_RS23550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CSC3H3_RS23555	COG1063	alcohol dehydrogenase
CSC3H3_RS23570	COG1454	alcohol dehydrogenase
CSC3H3_RS23575	COG4302	ethanolamine ammonia-lyase activity
CSC3H3_RS23615	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS23630	COG1172	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS23635	COG1172	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS23640	COG1129	ABC transporter
CSC3H3_RS23650	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CSC3H3_RS23655	COG1349	DNA-binding transcription factor activity
CSC3H3_RS23665	COG0179	Fumarylacetoacetate (FAA) hydrolase
CSC3H3_RS23670	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CSC3H3_RS23695	COG4638	Rieske (2fe-2S)
CSC3H3_RS23700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CSC3H3_RS23705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CSC3H3_RS23715	COG2086	electron transfer activity
CSC3H3_RS23725	COG0788	formyltetrahydrofolate deformylase activity
CSC3H3_RS23735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CSC3H3_RS23745	COG0446	pyridine nucleotide-disulphide oxidoreductase
CSC3H3_RS23745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CSC3H3_RS23785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSC3H3_RS23795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CSC3H3_RS23820	COG0747	negative chemotaxis
CSC3H3_RS23840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CSC3H3_RS23845	COG1126	abc transporter atp-binding protein
CSC3H3_RS23850	COG0765	amino acid transport
CSC3H3_RS23855	COG4597	amino acid ABC transporter
CSC3H3_RS23860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CSC3H3_RS23865	COG0583	DNA-binding transcription factor activity
CSC3H3_RS23870	COG0517	IMP dehydrogenase activity
CSC3H3_RS23870	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CSC3H3_RS23870	COG0617	tRNA 3'-terminal CCA addition
CSC3H3_RS23885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CSC3H3_RS23890	COG2814	Major facilitator Superfamily
CSC3H3_RS23895	COG4264	IucA IucC family
CSC3H3_RS23905	COG4264	IucA IucC family
CSC3H3_RS23910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CSC3H3_RS23915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CSC3H3_RS23920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CSC3H3_RS23925	COG1120	ATPase activity
CSC3H3_RS23950	COG0444	Belongs to the ABC transporter superfamily
CSC3H3_RS23955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CSC3H3_RS23960	COG0601	transmembrane transport
CSC3H3_RS23965	COG0747	negative chemotaxis
CSC3H3_RS23970	COG1802	Transcriptional regulator
CSC3H3_RS24000	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS24005	COG3246	L-lysine catabolic process to acetate
CSC3H3_RS24010	COG1250	3-hydroxyacyl-CoA dehydrogenase
CSC3H3_RS24025	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CSC3H3_RS24040	COG3273	potassium ion transport
CSC3H3_RS24040	COG0471	metal ion transport
CSC3H3_RS24045	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CSC3H3_RS24050	COG4208	sulfate ABC transporter
CSC3H3_RS24060	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CSC3H3_RS24065	COG1959	2 iron, 2 sulfur cluster binding
CSC3H3_RS24070	COG3842	ATPase activity
CSC3H3_RS24080	COG0395	ABC-type sugar transport system, permease component
CSC3H3_RS24085	COG1175	transmembrane transport
CSC3H3_RS24100	COG2207	Transcriptional regulator
CSC3H3_RS24115	COG1566	PFAM secretion protein HlyD family protein
CSC3H3_RS24130	COG1129	ABC transporter
CSC3H3_RS24135	COG1172	Belongs to the binding-protein-dependent transport system permease family
CSC3H3_RS24140	COG1879	ABC-type sugar transport system periplasmic component
CSC3H3_RS24145	COG1028	Short-chain dehydrogenase reductase Sdr
CSC3H3_RS24150	COG2376	Dihydroxyacetone kinase
CSC3H3_RS24160	COG2376	Dihydroxyacetone kinase
CSC3H3_RS24180	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CSC3H3_RS24185	COG1073	alpha beta
CSC3H3_RS24185	COG2226	methyltransferase