locus-tag	class	description
M9H61_RS00015	COG2391	methyltransferase activity
M9H61_RS00035	COG0513	Belongs to the DEAD box helicase family
M9H61_RS00040	COG1278	Cold shock
M9H61_RS00045	COG2186	Transcriptional regulator
M9H61_RS00055	COG0765	amino acid transport
M9H61_RS00060	COG0765	amino acid transport
M9H61_RS00075	COG1671	Belongs to the UPF0178 family
M9H61_RS00125	COG2814	Major facilitator Superfamily
M9H61_RS00130	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
M9H61_RS00135	COG0523	cobalamin synthesis protein
M9H61_RS00140	COG0625	glutathione transferase activity
M9H61_RS00145	COG0625	glutathione transferase activity
M9H61_RS00155	COG2814	Major facilitator Superfamily
M9H61_RS00160	COG0583	DNA-binding transcription factor activity
M9H61_RS00165	COG0477	Major facilitator Superfamily
M9H61_RS00170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M9H61_RS00175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M9H61_RS00180	COG1845	cytochrome c oxidase, subunit III
M9H61_RS00185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M9H61_RS00200	COG1309	transcriptional regulator
M9H61_RS00210	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M9H61_RS00230	COG0679	Auxin Efflux Carrier
M9H61_RS00235	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M9H61_RS00235	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M9H61_RS00250	COG3180	Ammonia monooxygenase
M9H61_RS00275	COG3300	MHYT domain
M9H61_RS00275	COG5001	Diguanylate cyclase
M9H61_RS00285	COG0745	RESPONSE REGULATOR receiver
M9H61_RS00290	COG1366	Belongs to the anti-sigma-factor antagonist family
M9H61_RS00295	COG2204	response regulator
M9H61_RS00325	COG1879	ABC-type sugar transport system periplasmic component
M9H61_RS00335	COG0772	Belongs to the SEDS family
M9H61_RS00340	COG0768	penicillin binding
M9H61_RS00365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M9H61_RS00375	COG1280	lysine exporter protein (LysE YggA)
M9H61_RS00390	COG3706	GGDEF domain
M9H61_RS00395	COG1278	Cold shock
M9H61_RS00400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M9H61_RS00425	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M9H61_RS00435	COG0840	transmembrane signaling receptor activity
M9H61_RS00445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M9H61_RS00445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M9H61_RS00455	COG0519	Catalyzes the synthesis of GMP from XMP
M9H61_RS00465	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS00475	COG3655	Transcriptional regulator
M9H61_RS00520	COG3909	cytochrome
M9H61_RS00535	COG0596	Alpha beta hydrolase
M9H61_RS00540	COG0494	nUDIX hydrolase
M9H61_RS00555	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M9H61_RS00560	COG0363	glucosamine-6-phosphate deaminase activity
M9H61_RS00565	COG0129	dihydroxy-acid dehydratase activity
M9H61_RS00570	COG0837	glucose binding
M9H61_RS00575	COG0800	Aldolase
M9H61_RS00620	COG2719	SpoVR family
M9H61_RS00625	COG2718	Belongs to the UPF0229 family
M9H61_RS00630	COG2766	serine protein kinase
M9H61_RS00635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M9H61_RS00645	COG0251	oxidation-reduction process
M9H61_RS00695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M9H61_RS00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M9H61_RS00720	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M9H61_RS00730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M9H61_RS00740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M9H61_RS00745	COG0222	ribosome binding
M9H61_RS00750	COG0085	RNA polymerase activity
M9H61_RS00755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M9H61_RS00770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M9H61_RS00775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M9H61_RS00785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M9H61_RS00790	COG0088	Forms part of the polypeptide exit tunnel
M9H61_RS00795	COG0089	rRNA binding
M9H61_RS00805	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M9H61_RS00815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M9H61_RS00820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M9H61_RS00825	COG0255	Belongs to the universal ribosomal protein uL29 family
M9H61_RS00840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M9H61_RS00845	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M9H61_RS00855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M9H61_RS00865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M9H61_RS00875	COG1841	ribosomal large subunit assembly
M9H61_RS00880	COG0200	Binds to the 23S rRNA
M9H61_RS00885	COG0201	protein transport
M9H61_RS00890	COG0563	adenylate kinase activity
M9H61_RS00895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M9H61_RS00900	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M9H61_RS00910	COG0203	ribosomal protein L17
M9H61_RS00915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M9H61_RS00920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M9H61_RS00925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M9H61_RS00935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M9H61_RS00940	COG0564	pseudouridine synthase activity
M9H61_RS00950	COG0546	phosphoglycolate phosphatase activity
M9H61_RS00965	COG0412	Dienelactone hydrolase
M9H61_RS00970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M9H61_RS00995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M9H61_RS01000	COG4770	biotin carboxylase activity
M9H61_RS01015	COG1254	Belongs to the acylphosphatase family
M9H61_RS01025	COG0277	FAD linked oxidase domain protein
M9H61_RS01030	COG0009	L-threonylcarbamoyladenylate synthase
M9H61_RS01045	COG1355	regulation of microtubule-based process
M9H61_RS01065	COG0456	acetyltransferase
M9H61_RS01075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M9H61_RS01105	COG2011	ABC-type metal ion transport system permease component
M9H61_RS01110	COG1464	Belongs to the NlpA lipoprotein family
M9H61_RS01115	COG1280	lysine exporter protein (LysE YggA)
M9H61_RS01130	COG0488	(ABC) transporter
M9H61_RS01135	COG0105	UTP biosynthetic process
M9H61_RS01160	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M9H61_RS01165	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M9H61_RS01175	COG0628	permease
M9H61_RS01180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M9H61_RS01185	COG4067	protein conserved in archaea
M9H61_RS01185	COG0189	ligase activity
M9H61_RS01190	COG0189	ligase activity
M9H61_RS01200	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M9H61_RS01205	COG1309	transcriptional regulator
M9H61_RS01220	COG0702	epimerase
M9H61_RS01225	COG0583	DNA-binding transcription factor activity
M9H61_RS01230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M9H61_RS01235	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M9H61_RS01250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M9H61_RS01265	COG0248	Ppx GppA phosphatase
M9H61_RS01295	COG0640	Transcriptional regulator
M9H61_RS01300	COG0123	including yeast histone deacetylase and acetoin utilization protein
M9H61_RS01320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M9H61_RS01335	COG0318	PFAM AMP-dependent synthetase and ligase
M9H61_RS01365	COG1802	Transcriptional regulator
M9H61_RS01370	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M9H61_RS01405	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M9H61_RS01410	COG1295	ribonuclease BN
M9H61_RS01415	COG0300	oxidoreductase activity
M9H61_RS01420	COG0668	transmembrane transport
M9H61_RS01425	COG0484	heat shock protein binding
M9H61_RS01430	COG4520	surface antigen
M9H61_RS01440	COG0640	Transcriptional regulator
M9H61_RS01455	COG2135	peptidase activity
M9H61_RS01460	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS01465	COG3153	acetyltransferase
M9H61_RS01475	COG0156	8-amino-7-oxononanoate synthase activity
M9H61_RS01480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M9H61_RS01495	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M9H61_RS01505	COG0659	secondary active sulfate transmembrane transporter activity
M9H61_RS01510	COG1024	Enoyl-CoA hydratase
M9H61_RS01520	COG2814	Major facilitator Superfamily
M9H61_RS01525	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS01530	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M9H61_RS01545	COG4191	Histidine kinase
M9H61_RS01550	COG3660	Nucleoside-diphosphate-sugar epimerase
M9H61_RS01560	COG0583	DNA-binding transcription factor activity
M9H61_RS01565	COG2814	Major facilitator Superfamily
M9H61_RS01570	COG0656	L-ascorbic acid biosynthetic process
M9H61_RS01575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M9H61_RS01585	COG1252	NADH dehydrogenase
M9H61_RS01590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M9H61_RS01595	COG0583	DNA-binding transcription factor activity
M9H61_RS01600	COG3622	Belongs to the hyi family
M9H61_RS01610	COG2186	Transcriptional regulator
M9H61_RS01620	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
M9H61_RS01660	COG3135	benzoate transporter
M9H61_RS01680	COG0483	inositol monophosphate 1-phosphatase activity
M9H61_RS01685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M9H61_RS01690	COG0352	thiamine-phosphate diphosphorylase activity
M9H61_RS01725	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M9H61_RS01735	COG1692	metallophosphoesterase
M9H61_RS01745	COG0840	transmembrane signaling receptor activity
M9H61_RS01750	COG0217	transcriptional regulatory protein
M9H61_RS01760	COG0632	four-way junction helicase activity
M9H61_RS01765	COG2255	four-way junction helicase activity
M9H61_RS01770	COG0824	Thioesterase
M9H61_RS01780	COG0848	biopolymer transport protein
M9H61_RS01795	COG2885	chlorophyll binding
M9H61_RS01805	COG0037	tRNA processing
M9H61_RS01810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M9H61_RS01815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M9H61_RS01820	COG0745	RESPONSE REGULATOR receiver
M9H61_RS01825	COG3852	Histidine kinase
M9H61_RS01830	COG2205	protein histidine kinase activity
M9H61_RS01835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M9H61_RS01840	COG0352	thiamine-phosphate diphosphorylase activity
M9H61_RS01840	COG0351	phosphomethylpyrimidine kinase
M9H61_RS01860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M9H61_RS01870	COG0129	dihydroxy-acid dehydratase activity
M9H61_RS01875	COG0686	Belongs to the AlaDH PNT family
M9H61_RS01880	COG1522	sequence-specific DNA binding
M9H61_RS01900	COG1177	transmembrane transport
M9H61_RS01905	COG1176	ABC-type spermidine putrescine transport system, permease component I
M9H61_RS01910	COG3842	ATPase activity
M9H61_RS01915	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M9H61_RS01920	COG0174	glutamine synthetase
M9H61_RS01930	COG4948	Mandelate Racemase Muconate Lactonizing
M9H61_RS01970	COG0842	Transport permease protein
M9H61_RS01975	COG0842	Transport permease protein
M9H61_RS01975	COG1129	ABC transporter
M9H61_RS01980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9H61_RS02000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M9H61_RS02005	COG0583	DNA-binding transcription factor activity
M9H61_RS02015	COG0247	lactate metabolic process
M9H61_RS02015	COG0277	FAD linked oxidase domain protein
M9H61_RS02020	COG0583	DNA-binding transcription factor activity
M9H61_RS02045	COG0110	maltose O-acetyltransferase activity
M9H61_RS02065	COG0642	Histidine kinase
M9H61_RS02070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M9H61_RS02095	COG2194	sulfuric ester hydrolase activity
M9H61_RS02105	COG0432	Pfam Uncharacterised protein family UPF0047
M9H61_RS02120	COG2132	Multicopper oxidase
M9H61_RS02155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M9H61_RS02160	COG3761	NADH ubiquinone oxidoreductase 17.2 kD subunit
M9H61_RS02175	COG4765	Protein conserved in bacteria
M9H61_RS02190	COG3038	cytochrome b561
M9H61_RS02205	COG0840	transmembrane signaling receptor activity
M9H61_RS02210	COG0400	carboxylic ester hydrolase activity
M9H61_RS02215	COG1280	lysine exporter protein (LysE YggA)
M9H61_RS02220	COG0534	Mate efflux family protein
M9H61_RS02225	COG1522	sequence-specific DNA binding
M9H61_RS02235	COG1959	2 iron, 2 sulfur cluster binding
M9H61_RS02240	COG0513	Belongs to the DEAD box helicase family
M9H61_RS02260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M9H61_RS02270	COG0187	DNA topoisomerase II activity
M9H61_RS02285	COG4608	Belongs to the ABC transporter superfamily
M9H61_RS02290	COG0444	Belongs to the ABC transporter superfamily
M9H61_RS02295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M9H61_RS02300	COG0601	transmembrane transport
M9H61_RS02305	COG0747	negative chemotaxis
M9H61_RS02340	COG0469	pyruvate kinase activity
M9H61_RS02360	COG0693	protein deglycase activity
M9H61_RS02365	COG0668	transmembrane transport
M9H61_RS02370	COG2885	chlorophyll binding
M9H61_RS02380	COG1832	CoA-binding protein
M9H61_RS02385	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
M9H61_RS02390	COG1280	lysine exporter protein (LysE YggA)
M9H61_RS02395	COG1024	Enoyl-CoA hydratase
M9H61_RS02415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M9H61_RS02420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M9H61_RS02440	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M9H61_RS02445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M9H61_RS02450	COG0697	spore germination
M9H61_RS02460	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M9H61_RS02475	COG1858	cytochrome C peroxidase
M9H61_RS02480	COG2084	Dehydrogenase
M9H61_RS02485	COG3243	poly(R)-hydroxyalkanoic acid synthase
M9H61_RS02495	COG0436	Aminotransferase
M9H61_RS02505	COG1494	fructose-1,6-bisphosphatase
M9H61_RS02515	COG0443	Heat shock 70 kDa protein
M9H61_RS02555	COG2223	nitrite transmembrane transporter activity
M9H61_RS02575	COG5002	protein histidine kinase activity
M9H61_RS02575	COG0784	Response regulator, receiver
M9H61_RS02580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M9H61_RS02600	COG1234	tRNA 3'-trailer cleavage
M9H61_RS02610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M9H61_RS02620	COG2972	Histidine kinase
M9H61_RS02620	COG0840	transmembrane signaling receptor activity
M9H61_RS02635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M9H61_RS02660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M9H61_RS02665	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M9H61_RS02670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M9H61_RS02675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M9H61_RS02680	COG1116	anion transmembrane transporter activity
M9H61_RS02685	COG0123	including yeast histone deacetylase and acetoin utilization protein
M9H61_RS02720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M9H61_RS02725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M9H61_RS02730	COG1120	ATPase activity
M9H61_RS02755	COG0523	cobalamin synthesis protein
M9H61_RS02770	COG1121	(ABC) transporter
M9H61_RS02775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M9H61_RS02780	COG0626	cystathionine gamma-synthase activity
M9H61_RS02785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M9H61_RS02790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M9H61_RS02805	COG2897	thiosulfate sulfurtransferase activity
M9H61_RS02810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M9H61_RS02825	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M9H61_RS02850	COG1620	l-lactate permease
M9H61_RS02855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M9H61_RS02865	COG2814	Major facilitator Superfamily
M9H61_RS02875	COG0494	nUDIX hydrolase
M9H61_RS02890	COG2195	Cleaves the N-terminal amino acid of tripeptides
M9H61_RS02910	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M9H61_RS02940	COG0730	response to heat
M9H61_RS02945	COG0425	Belongs to the sulfur carrier protein TusA family
M9H61_RS02950	COG2153	protein acetylation
M9H61_RS02965	COG2202	Pas domain
M9H61_RS02965	COG2199	diguanylate cyclase activity
M9H61_RS02965	COG2200	EAL domain
M9H61_RS02985	COG1067	ATP-dependent peptidase activity
M9H61_RS02990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M9H61_RS03000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M9H61_RS03015	COG3273	potassium ion transport
M9H61_RS03015	COG0471	metal ion transport
M9H61_RS03025	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M9H61_RS03050	COG0564	pseudouridine synthase activity
M9H61_RS03070	COG3448	diguanylate cyclase activity
M9H61_RS03070	COG4175	Glycine betaine
M9H61_RS03075	COG4176	ABC-type proline glycine betaine transport system permease component
M9H61_RS03080	COG2113	Glycine betaine
M9H61_RS03085	COG4176	ABC-type proline glycine betaine transport system permease component
M9H61_RS03090	COG4175	Glycine betaine
M9H61_RS03120	COG1840	ABC-type Fe3 transport system, periplasmic component
M9H61_RS03125	COG1840	ABC-type Fe3 transport system, periplasmic component
M9H61_RS03130	COG1840	ABC-type Fe3 transport system, periplasmic component
M9H61_RS03140	COG0303	'Molybdopterin
M9H61_RS03145	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M9H61_RS03155	COG0438	transferase activity, transferring glycosyl groups
M9H61_RS03160	COG0438	transferase activity, transferring glycosyl groups
M9H61_RS03190	COG4166	transmembrane transport
M9H61_RS03195	COG0601	transmembrane transport
M9H61_RS03200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M9H61_RS03210	COG2814	Major facilitator Superfamily
M9H61_RS03215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M9H61_RS03215	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M9H61_RS03220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M9H61_RS03225	COG1393	Belongs to the ArsC family
M9H61_RS03230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M9H61_RS03235	COG0405	Gamma-glutamyltransferase
M9H61_RS03250	COG2363	Small membrane protein
M9H61_RS03260	COG0793	Belongs to the peptidase S41A family
M9H61_RS03275	COG0557	exoribonuclease II activity
M9H61_RS03280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M9H61_RS03285	COG0758	DNA mediated transformation
M9H61_RS03285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M9H61_RS03295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M9H61_RS03315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M9H61_RS03320	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M9H61_RS03330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M9H61_RS03345	COG0583	DNA-binding transcription factor activity
M9H61_RS03350	COG1435	thymidine kinase activity
M9H61_RS03365	COG2995	paraquat-inducible protein a
M9H61_RS03370	COG3008	intermembrane lipid transfer
M9H61_RS03370	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M9H61_RS03390	COG2814	Major facilitator Superfamily
M9H61_RS03415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M9H61_RS03420	COG0737	Belongs to the 5'-nucleotidase family
M9H61_RS03425	COG1744	ABC transporter substrate-binding protein PnrA-like
M9H61_RS03430	COG3845	ABC transporter
M9H61_RS03440	COG1079	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS03445	COG0295	cytidine deaminase activity
M9H61_RS03450	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M9H61_RS03455	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M9H61_RS03470	COG0559	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS03480	COG0411	ABC transporter
M9H61_RS03505	COG1126	abc transporter atp-binding protein
M9H61_RS03510	COG0765	amino acid transport
M9H61_RS03515	COG4597	amino acid ABC transporter
M9H61_RS03520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M9H61_RS03525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M9H61_RS03530	COG0521	Mo-molybdopterin cofactor biosynthetic process
M9H61_RS03555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M9H61_RS03590	COG2814	Major facilitator Superfamily
M9H61_RS03615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M9H61_RS03625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M9H61_RS03640	COG0310	cobalt ion transport
M9H61_RS03665	COG0310	cobalt ion transport
M9H61_RS03685	COG0045	succinate-CoA ligase (ADP-forming) activity
M9H61_RS03685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M9H61_RS03685	COG1042	CoA-binding domain protein
M9H61_RS03710	COG0840	transmembrane signaling receptor activity
M9H61_RS03715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M9H61_RS03720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M9H61_RS03725	COG1538	Outer membrane efflux protein
M9H61_RS03735	COG0525	valine-tRNA ligase activity
M9H61_RS03745	COG0512	Glutamine amidotransferase of anthranilate synthase
M9H61_RS03760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M9H61_RS03775	COG0316	Belongs to the HesB IscA family
M9H61_RS03790	COG1472	Belongs to the glycosyl hydrolase 3 family
M9H61_RS03795	COG1994	Peptidase M50
M9H61_RS03805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M9H61_RS03810	COG3842	ATPase activity
M9H61_RS03815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M9H61_RS03820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M9H61_RS03840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M9H61_RS03845	COG4942	peptidase
M9H61_RS03855	COG1862	Preprotein translocase
M9H61_RS03860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M9H61_RS03880	COG0668	transmembrane transport
M9H61_RS03905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M9H61_RS03910	COG0191	fructose-bisphosphate aldolase activity
M9H61_RS03920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M9H61_RS03925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M9H61_RS03930	COG2188	Transcriptional regulator
M9H61_RS03935	COG2971	BadF BadG BcrA BcrD
M9H61_RS03940	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M9H61_RS03945	COG1653	transport
M9H61_RS03950	COG1175	transmembrane transport
M9H61_RS03960	COG3842	ATPase activity
M9H61_RS03975	COG3842	ATPase activity
M9H61_RS03985	COG1177	transmembrane transport
M9H61_RS03995	COG1175	transmembrane transport
M9H61_RS04000	COG0395	ABC-type sugar transport system, permease component
M9H61_RS04005	COG3842	ATPase activity
M9H61_RS04010	COG1956	GAF domain-containing protein
M9H61_RS04015	COG0629	single-stranded DNA binding
M9H61_RS04020	COG1051	belongs to the nudix hydrolase family
M9H61_RS04050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M9H61_RS04055	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M9H61_RS04060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M9H61_RS04070	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M9H61_RS04075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M9H61_RS04120	COG2824	Alkylphosphonate utilization operon protein PhnA
M9H61_RS04135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M9H61_RS04140	COG2951	lytic endotransglycosylase activity
M9H61_RS04150	COG1686	Belongs to the peptidase S11 family
M9H61_RS04155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M9H61_RS04170	COG0084	hydrolase, TatD family'
M9H61_RS04175	COG0321	lipoyl(octanoyl) transferase activity
M9H61_RS04175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M9H61_RS04200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M9H61_RS04225	COG0840	transmembrane signaling receptor activity
M9H61_RS04230	COG3180	Ammonia monooxygenase
M9H61_RS04245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M9H61_RS04250	COG0662	Cupin 2, conserved barrel domain protein
M9H61_RS04255	COG0527	aspartate kinase activity
M9H61_RS04260	COG3956	TIGRFAM MazG family protein
M9H61_RS04265	COG0483	inositol monophosphate 1-phosphatase activity
M9H61_RS04270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M9H61_RS04285	COG0569	domain protein
M9H61_RS04290	COG2204	response regulator
M9H61_RS04330	COG1324	tolerance protein
M9H61_RS04355	COG0776	regulation of translation
M9H61_RS04365	COG0416	fatty acid biosynthetic process
M9H61_RS04390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M9H61_RS04395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M9H61_RS04400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M9H61_RS04405	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M9H61_RS04405	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M9H61_RS04415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M9H61_RS04415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M9H61_RS04420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M9H61_RS04430	COG0698	ribose 5-phosphate isomerase
M9H61_RS04435	COG4957	zinc ion binding
M9H61_RS04440	COG0683	leucine binding
M9H61_RS04475	COG1024	Enoyl-CoA hydratase
M9H61_RS04480	COG1960	acyl-CoA dehydrogenase activity
M9H61_RS04495	COG0738	Major facilitator superfamily
M9H61_RS04500	COG0113	porphobilinogen synthase activity
M9H61_RS04505	COG1011	Hydrolase
M9H61_RS04515	COG0318	PFAM AMP-dependent synthetase and ligase
M9H61_RS04530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M9H61_RS04540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M9H61_RS04555	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M9H61_RS04560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS04570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M9H61_RS04575	COG1381	Involved in DNA repair and RecF pathway recombination
M9H61_RS04595	COG0571	ribonuclease III activity
M9H61_RS04600	COG0681	Belongs to the peptidase S26 family
M9H61_RS04605	COG0736	holo-[acyl-carrier-protein] synthase activity
M9H61_RS04610	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M9H61_RS04630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M9H61_RS04640	COG1573	uracil-dna glycosylase
M9H61_RS04645	COG0514	ATP-dependent DNA helicase (RecQ)
M9H61_RS04650	COG0386	Belongs to the glutathione peroxidase family
M9H61_RS04655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M9H61_RS04660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M9H61_RS04665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M9H61_RS04670	COG0741	lytic transglycosylase activity
M9H61_RS04685	COG0739	heme binding
M9H61_RS04690	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M9H61_RS04695	COG1546	Belongs to the CinA family
M9H61_RS04695	COG1058	Belongs to the CinA family
M9H61_RS04700	COG2867	negative regulation of translational initiation
M9H61_RS04705	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M9H61_RS04710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M9H61_RS04715	COG0508	dehydrogenase complex catalyzes the overall conversion of
M9H61_RS04720	COG0022	dehydrogenase e1 component
M9H61_RS04720	COG0508	dehydrogenase complex catalyzes the overall conversion of
M9H61_RS04725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M9H61_RS04735	COG0148	phosphopyruvate hydratase activity
M9H61_RS04755	COG0149	triose-phosphate isomerase activity
M9H61_RS04760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M9H61_RS04765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M9H61_RS04770	COG2861	carbohydrate metabolic process
M9H61_RS04795	COG0315	cyclic pyranopterin monophosphate synthase activity
M9H61_RS04805	COG0658	competence protein
M9H61_RS04805	COG2333	competence protein COMEC
M9H61_RS04810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M9H61_RS04815	COG0372	Belongs to the citrate synthase family
M9H61_RS04825	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9H61_RS04830	COG3494	Protein of unknown function (DUF1009)
M9H61_RS04835	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9H61_RS04840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M9H61_RS04845	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9H61_RS04860	COG0750	zinc metalloprotease
M9H61_RS04865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M9H61_RS04875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M9H61_RS04890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M9H61_RS04915	COG0442	prolyl-tRNA aminoacylation
M9H61_RS04930	COG0346	lactoylglutathione lyase activity
M9H61_RS04965	COG0713	ATP synthesis coupled electron transport
M9H61_RS04975	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9H61_RS04980	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M9H61_RS04985	COG1034	ATP synthesis coupled electron transport
M9H61_RS04990	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M9H61_RS04995	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M9H61_RS05010	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9H61_RS05015	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9H61_RS05025	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M9H61_RS05045	COG0776	regulation of translation
M9H61_RS05080	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M9H61_RS05080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M9H61_RS05090	COG2205	protein histidine kinase activity
M9H61_RS05090	COG2202	Pas domain
M9H61_RS05105	COG2217	Heavy metal translocating P-type atpase
M9H61_RS05110	COG2193	ferroxidase activity
M9H61_RS05120	COG3046	protein related to deoxyribodipyrimidine photolyase
M9H61_RS05135	COG1175	transmembrane transport
M9H61_RS05140	COG0395	ABC-type sugar transport system, permease component
M9H61_RS05145	COG3842	ATPase activity
M9H61_RS05165	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
M9H61_RS05195	COG0010	Belongs to the arginase family
M9H61_RS05200	COG1012	belongs to the aldehyde dehydrogenase family
M9H61_RS05205	COG1396	sequence-specific DNA binding
M9H61_RS05205	COG1917	Cupin 2, conserved barrel domain protein
M9H61_RS05210	COG0174	glutamine synthetase
M9H61_RS05220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M9H61_RS05230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M9H61_RS05235	COG1760	l-serine dehydratase
M9H61_RS05250	COG1012	belongs to the aldehyde dehydrogenase family
M9H61_RS05265	COG4176	ABC-type proline glycine betaine transport system permease component
M9H61_RS05280	COG0583	DNA-binding transcription factor activity
M9H61_RS05300	COG3842	ATPase activity
M9H61_RS05305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M9H61_RS05310	COG3246	L-lysine catabolic process to acetate
M9H61_RS05325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M9H61_RS05330	COG0251	oxidation-reduction process
M9H61_RS05350	COG2423	ornithine cyclodeaminase activity
M9H61_RS05365	COG3616	Alanine racemase, N-terminal domain
M9H61_RS05375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M9H61_RS05380	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS05390	COG0251	oxidation-reduction process
M9H61_RS05410	COG0729	surface antigen
M9H61_RS05415	COG0189	ligase activity
M9H61_RS05450	COG0183	Belongs to the thiolase family
M9H61_RS05455	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M9H61_RS05460	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M9H61_RS05465	COG3485	protocatechuate 3,4-dioxygenase
M9H61_RS05470	COG3485	protocatechuate 3,4-dioxygenase
M9H61_RS05480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M9H61_RS05485	COG0583	DNA-binding transcription factor activity
M9H61_RS05510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M9H61_RS05525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M9H61_RS05525	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M9H61_RS05545	COG2814	Major facilitator Superfamily
M9H61_RS05555	COG2375	cellular response to nickel ion
M9H61_RS05580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS05595	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M9H61_RS05625	COG3769	mannosylglycerate metabolic process
M9H61_RS05630	COG1215	transferase activity, transferring glycosyl groups
M9H61_RS05650	COG0366	Alpha amylase catalytic
M9H61_RS05690	COG2186	Transcriptional regulator
M9H61_RS05700	COG1172	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS05705	COG1172	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS05710	COG1129	ABC transporter
M9H61_RS05715	COG1879	ABC-type sugar transport system periplasmic component
M9H61_RS05735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS05745	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M9H61_RS05750	COG1802	Transcriptional regulator
M9H61_RS05795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M9H61_RS05810	COG0308	aminopeptidase N
M9H61_RS05825	COG0628	permease
M9H61_RS05830	COG1917	Cupin 2, conserved barrel domain protein
M9H61_RS05830	COG2207	Transcriptional regulator
M9H61_RS05835	COG1280	lysine exporter protein (LysE YggA)
M9H61_RS05855	COG5002	protein histidine kinase activity
M9H61_RS05865	COG2205	protein histidine kinase activity
M9H61_RS05875	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M9H61_RS05880	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M9H61_RS05905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M9H61_RS05910	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M9H61_RS05925	COG0848	biopolymer transport protein
M9H61_RS05935	COG0811	peptide transport
M9H61_RS05960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M9H61_RS05965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M9H61_RS05995	COG0418	dihydroorotase activity
M9H61_RS06000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M9H61_RS06020	COG0436	Aminotransferase
M9H61_RS06035	COG0457	Tetratricopeptide repeat
M9H61_RS06040	COG0457	Tetratricopeptide repeat
M9H61_RS06045	COG0457	Tetratricopeptide repeat
M9H61_RS06060	COG1765	OsmC-like protein
M9H61_RS06085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M9H61_RS06090	COG0457	Tetratricopeptide repeat
M9H61_RS06095	COG2200	EAL domain
M9H61_RS06095	COG2199	diguanylate cyclase activity
M9H61_RS06095	COG3287	FIST C domain
M9H61_RS06110	COG1802	Transcriptional regulator
M9H61_RS06115	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M9H61_RS06115	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS06125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M9H61_RS06130	COG2207	Transcriptional regulator
M9H61_RS06130	COG3708	Transcriptional regulator
M9H61_RS06150	COG0625	glutathione transferase activity
M9H61_RS06165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M9H61_RS06185	COG0697	spore germination
M9H61_RS06215	COG0482	sulfurtransferase activity
M9H61_RS06220	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M9H61_RS06225	COG2975	iron-sulfur cluster assembly
M9H61_RS06230	COG0633	Ferredoxin
M9H61_RS06235	COG0443	Heat shock 70 kDa protein
M9H61_RS06240	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M9H61_RS06245	COG0316	Belongs to the HesB IscA family
M9H61_RS06250	COG0822	iron-sulfur transferase activity
M9H61_RS06265	COG1959	2 iron, 2 sulfur cluster binding
M9H61_RS06270	COG1045	serine acetyltransferase
M9H61_RS06275	COG2945	thiolester hydrolase activity
M9H61_RS06280	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M9H61_RS06310	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M9H61_RS06315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M9H61_RS06325	COG2833	Protein of unknown function (DUF455)
M9H61_RS06365	COG0860	N-Acetylmuramoyl-L-alanine amidase
M9H61_RS06370	COG1530	ribonuclease E activity
M9H61_RS06375	COG0436	Aminotransferase
M9H61_RS06395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M9H61_RS06395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M9H61_RS06410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M9H61_RS06415	COG0511	ligase activity, forming carbon-carbon bonds
M9H61_RS06420	COG0439	Biotin carboxylase
M9H61_RS06425	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M9H61_RS06435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M9H61_RS06445	COG2972	Histidine kinase
M9H61_RS06445	COG0840	transmembrane signaling receptor activity
M9H61_RS06465	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M9H61_RS06485	COG1686	Belongs to the peptidase S11 family
M9H61_RS06495	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M9H61_RS06500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M9H61_RS06525	COG0579	oxidoreductase
M9H61_RS06555	COG4774	siderophore transport
M9H61_RS06580	COG0506	proline dehydrogenase activity
M9H61_RS06580	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M9H61_RS06580	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M9H61_RS06595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M9H61_RS06600	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M9H61_RS06605	COG4770	biotin carboxylase activity
M9H61_RS06620	COG0840	transmembrane signaling receptor activity
M9H61_RS06630	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M9H61_RS06645	COG0583	DNA-binding transcription factor activity
M9H61_RS06660	COG2084	Dehydrogenase
M9H61_RS06665	COG0793	Belongs to the peptidase S41A family
M9H61_RS06670	COG1960	acyl-CoA dehydrogenase activity
M9H61_RS06675	COG0795	lipopolysaccharide-transporting ATPase activity
M9H61_RS06685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M9H61_RS06690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M9H61_RS06695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M9H61_RS06700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M9H61_RS06705	COG0194	GDP metabolic process
M9H61_RS06710	COG1561	YicC-like family, N-terminal region
M9H61_RS06720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M9H61_RS06725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M9H61_RS06740	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M9H61_RS06750	COG0360	Binds together with S18 to 16S ribosomal RNA
M9H61_RS06755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M9H61_RS06765	COG0359	binds to the 23S rRNA
M9H61_RS06770	COG0305	Participates in initiation and elongation during chromosome replication
M9H61_RS06775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M9H61_RS06780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M9H61_RS06785	COG1127	ABC transporter
M9H61_RS06800	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M9H61_RS06805	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS06815	COG1160	GTP binding
M9H61_RS06850	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M9H61_RS06855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M9H61_RS06870	COG0071	Belongs to the small heat shock protein (HSP20) family
M9H61_RS06875	COG1902	pentaerythritol trinitrate reductase activity
M9H61_RS06880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M9H61_RS06895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M9H61_RS06905	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M9H61_RS06910	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M9H61_RS06915	COG1091	dTDP-4-dehydrorhamnose reductase activity
M9H61_RS06920	COG1088	dTDP-glucose 4,6-dehydratase activity
M9H61_RS06925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M9H61_RS06930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M9H61_RS06935	COG0546	phosphoglycolate phosphatase activity
M9H61_RS06945	COG0129	dihydroxy-acid dehydratase activity
M9H61_RS06950	COG4214	carbohydrate transport
M9H61_RS06960	COG4213	ABC transporter substrate-binding protein
M9H61_RS07005	COG1234	tRNA 3'-trailer cleavage
M9H61_RS07020	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M9H61_RS07095	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M9H61_RS07100	COG2205	protein histidine kinase activity
M9H61_RS07120	COG1283	sodium-dependent phosphate transmembrane transporter activity
M9H61_RS07135	COG0367	asparagine synthase
M9H61_RS07145	COG3284	Transcriptional regulator
M9H61_RS07150	COG1012	belongs to the aldehyde dehydrogenase family
M9H61_RS07160	COG2855	membrane
M9H61_RS07165	COG0583	DNA-binding transcription factor activity
M9H61_RS07175	COG1271	oxidase subunit
M9H61_RS07180	COG1294	oxidase, subunit
M9H61_RS07190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M9H61_RS07215	COG0175	sulfate reduction
M9H61_RS07235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M9H61_RS07250	COG2827	Endonuclease containing a URI domain
M9H61_RS07255	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS07260	COG0800	Aldolase
M9H61_RS07265	COG3734	2-keto-3-deoxy-galactonokinase
M9H61_RS07275	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M9H61_RS07315	COG3938	Belongs to the proline racemase family
M9H61_RS07330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M9H61_RS07335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M9H61_RS07340	COG0438	transferase activity, transferring glycosyl groups
M9H61_RS07355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M9H61_RS07380	COG2814	Major facilitator Superfamily
M9H61_RS07405	COG3842	ATPase activity
M9H61_RS07420	COG0395	ABC-type sugar transport system, permease component
M9H61_RS07445	COG0746	molybdenum cofactor guanylyltransferase activity
M9H61_RS07465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M9H61_RS07470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M9H61_RS07485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M9H61_RS07490	COG1309	transcriptional regulator
M9H61_RS07510	COG0493	'glutamate synthase
M9H61_RS07520	COG2814	Major facilitator Superfamily
M9H61_RS07525	COG1566	PFAM secretion protein HlyD family protein
M9H61_RS07535	COG0826	peptidase U32
M9H61_RS07550	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M9H61_RS07570	COG0784	Response regulator, receiver
M9H61_RS07570	COG5002	protein histidine kinase activity
M9H61_RS07570	COG2205	protein histidine kinase activity
M9H61_RS07580	COG3842	ATPase activity
M9H61_RS07585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M9H61_RS07590	COG0395	ABC-type sugar transport system, permease component
M9H61_RS07605	COG1940	carbohydrate kinase activity
M9H61_RS07610	COG3386	PFAM SMP-30 Gluconolaconase
M9H61_RS07615	COG1120	ATPase activity
M9H61_RS07655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M9H61_RS07670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M9H61_RS07675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M9H61_RS07690	COG2186	Transcriptional regulator
M9H61_RS07695	COG2017	converts alpha-aldose to the beta-anomer
M9H61_RS07700	COG2186	Transcriptional regulator
M9H61_RS07705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M9H61_RS07710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M9H61_RS07715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M9H61_RS07720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9H61_RS07750	COG4120	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS07760	COG4774	siderophore transport
M9H61_RS07775	COG1595	DNA-templated transcription, initiation
M9H61_RS07780	COG1024	Enoyl-CoA hydratase
M9H61_RS07790	COG1725	Transcriptional regulator
M9H61_RS07795	COG0626	cystathionine gamma-synthase activity
M9H61_RS07805	COG1175	transmembrane transport
M9H61_RS07810	COG0395	ABC-type sugar transport system, permease component
M9H61_RS07815	COG3842	ATPase activity
M9H61_RS07825	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M9H61_RS07835	COG0697	spore germination
M9H61_RS07855	COG0167	dihydroorotate dehydrogenase activity
M9H61_RS07865	COG1902	pentaerythritol trinitrate reductase activity
M9H61_RS07880	COG0583	DNA-binding transcription factor activity
M9H61_RS07885	COG0384	phenazine biosynthesis protein PhzF
M9H61_RS07895	COG1569	PIN domain
M9H61_RS07900	COG3311	Transcriptional regulator
M9H61_RS07935	COG3609	addiction module antidote protein, CC2985 family
M9H61_RS08050	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS08060	COG1850	ribulose-bisphosphate carboxylase activity
M9H61_RS08080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M9H61_RS08105	COG0583	DNA-binding transcription factor activity
M9H61_RS08125	COG0840	transmembrane signaling receptor activity
M9H61_RS08130	COG1846	Transcriptional regulator
M9H61_RS08140	COG1764	response to oxidative stress
M9H61_RS08150	COG1349	DNA-binding transcription factor activity
M9H61_RS08160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M9H61_RS08165	COG1238	metal cluster binding
M9H61_RS08180	COG1917	Cupin 2, conserved barrel domain protein
M9H61_RS08180	COG2207	Transcriptional regulator
M9H61_RS08190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M9H61_RS08200	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M9H61_RS08200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS08205	COG1199	ATP-dependent helicase activity
M9H61_RS08210	COG1819	glycosyl
M9H61_RS08230	COG3247	response to pH
M9H61_RS08255	COG2084	Dehydrogenase
M9H61_RS08265	COG2890	protein-(glutamine-N5) methyltransferase activity
M9H61_RS08270	COG2900	Belongs to the SlyX family
M9H61_RS08280	COG0583	DNA-binding transcription factor activity
M9H61_RS08295	COG1396	sequence-specific DNA binding
M9H61_RS08325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M9H61_RS08330	COG0154	amidase activity
M9H61_RS08335	COG1643	Atp-dependent helicase
M9H61_RS08400	COG0438	transferase activity, transferring glycosyl groups
M9H61_RS08415	COG0495	leucyl-tRNA aminoacylation
M9H61_RS08460	COG2226	methyltransferase
M9H61_RS08465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M9H61_RS08470	COG0720	synthase
M9H61_RS08475	COG0602	queuosine metabolic process
M9H61_RS08490	COG2207	Transcriptional regulator
M9H61_RS08490	COG3708	Transcriptional regulator
M9H61_RS08510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M9H61_RS08530	COG0688	phosphatidylethanolamine metabolic process
M9H61_RS08545	COG1611	Belongs to the LOG family
M9H61_RS08555	COG1349	DNA-binding transcription factor activity
M9H61_RS08575	COG0395	ABC-type sugar transport system, permease component
M9H61_RS08610	COG0538	isocitrate dehydrogenase activity
M9H61_RS08640	COG1595	DNA-templated transcription, initiation
M9H61_RS08665	COG0655	NAD(P)H dehydrogenase (quinone) activity
M9H61_RS08670	COG0584	glycerophosphoryl diester phosphodiesterase
M9H61_RS08680	COG1755	Isoprenylcysteine carboxyl methyltransferase
M9H61_RS08685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M9H61_RS08705	COG1309	transcriptional regulator
M9H61_RS08715	COG1176	ABC-type spermidine putrescine transport system, permease component I
M9H61_RS08720	COG1177	transmembrane transport
M9H61_RS08730	COG3842	ATPase activity
M9H61_RS08765	COG3708	Transcriptional regulator
M9H61_RS08765	COG2207	Transcriptional regulator
M9H61_RS08770	COG1522	sequence-specific DNA binding
M9H61_RS08775	COG0697	spore germination
M9H61_RS08785	COG0519	Catalyzes the synthesis of GMP from XMP
M9H61_RS08795	COG5487	UPF0391 membrane protein
M9H61_RS08820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M9H61_RS08895	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M9H61_RS08905	COG1987	bacterial-type flagellum assembly
M9H61_RS08910	COG1677	Flagellar hook-basal body complex protein FliE
M9H61_RS08915	COG1558	bacterial-type flagellum-dependent cell motility
M9H61_RS08920	COG1815	bacterial-type flagellum-dependent cell motility
M9H61_RS08930	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M9H61_RS08945	COG1338	Plays a role in the flagellum-specific transport system
M9H61_RS08975	COG0745	RESPONSE REGULATOR receiver
M9H61_RS09005	COG4786	Flagellar basal body rod
M9H61_RS09010	COG4786	Flagellar basal body rod
M9H61_RS09020	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M9H61_RS09035	COG1706	bacterial-type flagellum-dependent cell motility
M9H61_RS09040	COG3951	Flagellar rod assembly protein muramidase FlgJ
M9H61_RS09055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M9H61_RS09065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M9H61_RS09070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M9H61_RS09075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M9H61_RS09080	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M9H61_RS09095	COG1516	flagellar protein fliS
M9H61_RS09110	COG1749	Flagellar hook protein flgE
M9H61_RS09115	COG1766	The M ring may be actively involved in energy transduction
M9H61_RS09125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M9H61_RS09130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M9H61_RS09135	COG2204	response regulator
M9H61_RS09140	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M9H61_RS09165	COG3128	pkhd-type hydroxylase
M9H61_RS09170	COG4136	ATPase activity
M9H61_RS09175	COG4135	transport system, permease component
M9H61_RS09180	COG4134	Bacterial extracellular solute-binding protein
M9H61_RS09185	COG0861	Integral membrane protein TerC family
M9H61_RS09205	COG0745	RESPONSE REGULATOR receiver
M9H61_RS09230	COG0745	RESPONSE REGULATOR receiver
M9H61_RS09240	COG0643	Histidine kinase
M9H61_RS09240	COG0784	Response regulator, receiver
M9H61_RS09240	COG2198	Histidine kinase
M9H61_RS09280	COG2962	Rard protein
M9H61_RS09285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M9H61_RS09290	COG0668	transmembrane transport
M9H61_RS09295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M9H61_RS09305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M9H61_RS09325	COG1070	Carbohydrate kinase
M9H61_RS09340	COG1172	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS09355	COG3347	Dehydrogenase
M9H61_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS09385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M9H61_RS09395	COG0393	Putative heavy-metal-binding
M9H61_RS09415	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M9H61_RS09430	COG1739	Uncharacterized protein family UPF0029
M9H61_RS09435	COG1609	Transcriptional regulator
M9H61_RS09440	COG3265	gluconokinase activity
M9H61_RS09445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M9H61_RS09475	COG0175	sulfate reduction
M9H61_RS09485	COG1612	heme a metabolic process
M9H61_RS09490	COG0312	modulator of DNA gyrase
M9H61_RS09520	COG0747	negative chemotaxis
M9H61_RS09525	COG0601	transmembrane transport
M9H61_RS09530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M9H61_RS09535	COG0444	Belongs to the ABC transporter superfamily
M9H61_RS09540	COG4608	Belongs to the ABC transporter superfamily
M9H61_RS09545	COG1280	lysine exporter protein (LysE YggA)
M9H61_RS09555	COG2847	Copper chaperone PCu(A)C
M9H61_RS09575	COG1349	DNA-binding transcription factor activity
M9H61_RS09590	COG3639	organic phosphonate transmembrane transporter activity
M9H61_RS09600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M9H61_RS09655	COG0312	modulator of DNA gyrase
M9H61_RS09660	COG0840	transmembrane signaling receptor activity
M9H61_RS09670	COG1597	lipid kinase activity
M9H61_RS09680	COG0438	transferase activity, transferring glycosyl groups
M9H61_RS09680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M9H61_RS09690	COG1132	(ABC) transporter
M9H61_RS09700	COG1519	Transferase
M9H61_RS09705	COG1663	tetraacyldisaccharide 4'-kinase activity
M9H61_RS09725	COG0405	Gamma-glutamyltransferase
M9H61_RS09735	COG1570	exodeoxyribonuclease VII activity
M9H61_RS09740	COG0151	Belongs to the GarS family
M9H61_RS09745	COG1120	ATPase activity
M9H61_RS09750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M9H61_RS09760	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M9H61_RS09765	COG2207	Transcriptional regulator
M9H61_RS09770	COG4221	oxidoreductase activity
M9H61_RS09780	COG2226	methyltransferase
M9H61_RS09790	COG0590	tRNA wobble adenosine to inosine editing
M9H61_RS09795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M9H61_RS09800	COG1187	pseudouridine synthase activity
M9H61_RS09805	COG0742	ribosomal rna small subunit methyltransferase
M9H61_RS09830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M9H61_RS09860	COG0783	Belongs to the Dps family
M9H61_RS09865	COG1597	lipid kinase activity
M9H61_RS09870	COG0552	protein localization to endoplasmic reticulum
M9H61_RS09875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M9H61_RS09885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M9H61_RS09890	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M9H61_RS09895	COG0706	membrane insertase activity
M9H61_RS09900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M9H61_RS09910	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M9H61_RS09920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9H61_RS09925	COG2274	protein secretion by the type I secretion system
M9H61_RS10035	COG2239	Acts as a magnesium transporter
M9H61_RS10040	COG0280	phosphate acetyltransferase
M9H61_RS10040	COG0281	malic enzyme
M9H61_RS10085	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M9H61_RS10105	COG0604	alcohol dehydrogenase
M9H61_RS10110	COG1733	regulation of RNA biosynthetic process
M9H61_RS10130	COG1234	tRNA 3'-trailer cleavage
M9H61_RS10145	COG1012	belongs to the aldehyde dehydrogenase family
M9H61_RS10150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M9H61_RS10160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M9H61_RS10165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M9H61_RS10170	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M9H61_RS10175	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS10180	COG3473	Maleate cis-trans isomerase
M9H61_RS10185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M9H61_RS10190	COG2423	ornithine cyclodeaminase activity
M9H61_RS10195	COG0006	proline dipeptidase activity
M9H61_RS10200	COG3608	succinylglutamate desuccinylase aspartoacylase
M9H61_RS10205	COG1522	sequence-specific DNA binding
M9H61_RS10220	COG0154	amidase activity
M9H61_RS10235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M9H61_RS10245	COG0673	inositol 2-dehydrogenase activity
M9H61_RS10255	COG1879	ABC-type sugar transport system periplasmic component
M9H61_RS10260	COG1172	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS10265	COG1129	ABC transporter
M9H61_RS10270	COG1609	Transcriptional regulator
M9H61_RS10280	COG0019	diaminopimelate decarboxylase activity
M9H61_RS10290	COG1522	sequence-specific DNA binding
M9H61_RS10310	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M9H61_RS10320	COG0745	RESPONSE REGULATOR receiver
M9H61_RS10325	COG2205	protein histidine kinase activity
M9H61_RS10330	COG0583	DNA-binding transcription factor activity
M9H61_RS10335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M9H61_RS10340	COG3842	ATPase activity
M9H61_RS10345	COG1176	ABC-type spermidine putrescine transport system, permease component I
M9H61_RS10350	COG1177	transmembrane transport
M9H61_RS10355	COG1012	belongs to the aldehyde dehydrogenase family
M9H61_RS10385	COG2186	Transcriptional regulator
M9H61_RS10390	COG0405	Gamma-glutamyltransferase
M9H61_RS10395	COG0625	glutathione transferase activity
M9H61_RS10405	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M9H61_RS10415	COG1522	sequence-specific DNA binding
M9H61_RS10420	COG0410	ABC transporter
M9H61_RS10445	COG3800	Transcriptional regulator
M9H61_RS10445	COG1396	sequence-specific DNA binding
M9H61_RS10460	COG5002	protein histidine kinase activity
M9H61_RS10465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M9H61_RS10465	COG1116	anion transmembrane transporter activity
M9H61_RS10475	COG2223	nitrite transmembrane transporter activity
M9H61_RS10480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M9H61_RS10485	COG2146	nitrite reductase [NAD(P)H] activity
M9H61_RS10490	COG0243	molybdopterin cofactor binding
M9H61_RS10495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M9H61_RS10495	COG1648	precorrin-2 dehydrogenase activity
M9H61_RS10540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M9H61_RS10550	COG0318	PFAM AMP-dependent synthetase and ligase
M9H61_RS10600	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS10605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M9H61_RS10610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M9H61_RS10620	COG0667	Aldo Keto reductase
M9H61_RS10630	COG2376	Dihydroxyacetone kinase
M9H61_RS10635	COG1172	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS10640	COG1129	ABC transporter
M9H61_RS10650	COG1172	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS10680	COG1012	belongs to the aldehyde dehydrogenase family
M9H61_RS10695	COG1132	(ABC) transporter
M9H61_RS10700	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M9H61_RS10705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M9H61_RS10730	COG2188	Transcriptional regulator
M9H61_RS10740	COG1228	amidohydrolase
M9H61_RS10745	COG2986	histidine ammonia-lyase
M9H61_RS10760	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M9H61_RS10770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS10775	COG3852	Histidine kinase
M9H61_RS10805	COG1129	ABC transporter
M9H61_RS10815	COG1454	alcohol dehydrogenase
M9H61_RS10820	COG1012	belongs to the aldehyde dehydrogenase family
M9H61_RS10825	COG1454	alcohol dehydrogenase
M9H61_RS10840	COG1238	metal cluster binding
M9H61_RS10845	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M9H61_RS10865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M9H61_RS10890	COG0583	DNA-binding transcription factor activity
M9H61_RS10895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M9H61_RS10915	COG0271	Belongs to the BolA IbaG family
M9H61_RS10940	COG0517	IMP dehydrogenase activity
M9H61_RS10940	COG0516	GMP reductase activity
M9H61_RS10945	COG4536	flavin adenine dinucleotide binding
M9H61_RS10950	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M9H61_RS10975	COG2200	EAL domain
M9H61_RS10975	COG2202	Pas domain
M9H61_RS10975	COG2199	diguanylate cyclase activity
M9H61_RS10990	COG0617	tRNA 3'-terminal CCA addition
M9H61_RS11010	COG0714	Associated with various cellular activities
M9H61_RS11030	COG0583	DNA-binding transcription factor activity
M9H61_RS11035	COG0435	Glutathione S-transferase
M9H61_RS11070	COG1196	nuclear chromosome segregation
M9H61_RS11085	COG1194	a g-specific adenine glycosylase
M9H61_RS11100	COG1744	ABC transporter substrate-binding protein PnrA-like
M9H61_RS11105	COG3845	ABC transporter
M9H61_RS11110	COG4603	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS11120	COG0402	S-adenosylhomocysteine deaminase activity
M9H61_RS11125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M9H61_RS11135	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
M9H61_RS11165	COG0679	Auxin Efflux Carrier
M9H61_RS11175	COG5265	(ABC) transporter
M9H61_RS11180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M9H61_RS11185	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M9H61_RS11190	COG0799	negative regulation of ribosome biogenesis
M9H61_RS11200	COG0840	transmembrane signaling receptor activity
M9H61_RS11205	COG0840	transmembrane signaling receptor activity
M9H61_RS11210	COG1349	DNA-binding transcription factor activity
M9H61_RS11215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M9H61_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS11235	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M9H61_RS11240	COG1760	l-serine dehydratase
M9H61_RS11245	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M9H61_RS11250	COG4942	peptidase
M9H61_RS11255	COG0793	Belongs to the peptidase S41A family
M9H61_RS11265	COG0494	nUDIX hydrolase
M9H61_RS11275	COG4106	trans-aconitate 2-methyltransferase activity
M9H61_RS11305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M9H61_RS11330	COG2010	Cytochrome c
M9H61_RS11345	COG2217	Heavy metal translocating P-type atpase
M9H61_RS11355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M9H61_RS11370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M9H61_RS11375	COG0228	four-way junction DNA binding
M9H61_RS11405	COG0066	3-isopropylmalate dehydratase activity
M9H61_RS11415	COG1595	DNA-templated transcription, initiation
M9H61_RS11420	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M9H61_RS11430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M9H61_RS11435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M9H61_RS11455	COG0395	ABC-type sugar transport system, permease component
M9H61_RS11465	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS11475	COG3273	potassium ion transport
M9H61_RS11475	COG0471	metal ion transport
M9H61_RS11485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M9H61_RS11490	COG1872	DUF167
M9H61_RS11500	COG0519	Catalyzes the synthesis of GMP from XMP
M9H61_RS11505	COG0438	transferase activity, transferring glycosyl groups
M9H61_RS11510	COG1609	Transcriptional regulator
M9H61_RS11525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M9H61_RS11530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9H61_RS11545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M9H61_RS11555	COG1178	ABC-type Fe3 transport system permease component
M9H61_RS11560	COG1176	ABC-type spermidine putrescine transport system, permease component I
M9H61_RS11565	COG3842	ATPase activity
M9H61_RS11615	COG0798	PFAM Bile acid sodium symporter
M9H61_RS11620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M9H61_RS11630	COG1702	phosphate starvation-inducible protein PhoH
M9H61_RS11635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M9H61_RS11635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M9H61_RS11640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M9H61_RS11645	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M9H61_RS11650	COG1138	Cytochrome C-type biogenesis protein
M9H61_RS11655	COG4235	cytochrome complex assembly
M9H61_RS11660	COG0784	Response regulator, receiver
M9H61_RS11695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M9H61_RS11715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M9H61_RS11725	COG4974	Belongs to the 'phage' integrase family
M9H61_RS11735	COG0625	glutathione transferase activity
M9H61_RS11745	COG0174	glutamine synthetase
M9H61_RS11750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M9H61_RS11760	COG0494	nUDIX hydrolase
M9H61_RS11765	COG1196	nuclear chromosome segregation
M9H61_RS11765	COG3264	Mechanosensitive ion channel
M9H61_RS11770	COG0598	Magnesium transport protein CorA
M9H61_RS11775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M9H61_RS11780	COG0039	L-malate dehydrogenase activity
M9H61_RS11785	COG0045	succinate-CoA ligase (ADP-forming) activity
M9H61_RS11790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M9H61_RS11800	COG0508	dehydrogenase complex catalyzes the overall conversion of
M9H61_RS11805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M9H61_RS11810	COG1803	Methylglyoxal synthase
M9H61_RS11820	COG0564	pseudouridine synthase activity
M9H61_RS11830	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS11845	COG2211	Major facilitator Superfamily
M9H61_RS11850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M9H61_RS11860	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
M9H61_RS11865	COG1595	DNA-templated transcription, initiation
M9H61_RS11870	COG3806	Anti-sigma factor
M9H61_RS11875	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M9H61_RS11900	COG3706	GGDEF domain
M9H61_RS11905	COG2081	HI0933 family
M9H61_RS11915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS11935	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M9H61_RS11940	COG0024	Methionine aminopeptidase
M9H61_RS11950	COG3485	protocatechuate 3,4-dioxygenase
M9H61_RS11955	COG3485	protocatechuate 3,4-dioxygenase
M9H61_RS11960	COG0583	DNA-binding transcription factor activity
M9H61_RS11970	COG2188	Transcriptional regulator
M9H61_RS11975	COG3624	Phosphonate C-P lyase system protein PhnG
M9H61_RS11985	COG3626	phosphonate metabolism
M9H61_RS11990	COG3627	carbon phosphorus lyase activity
M9H61_RS11995	COG4107	phosphonate C-P lyase system protein PhnK
M9H61_RS12000	COG4778	phosphonate C-P lyase system protein PhnL
M9H61_RS12005	COG3454	Phosphonate metabolism
M9H61_RS12010	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M9H61_RS12010	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
M9H61_RS12015	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
M9H61_RS12025	COG3639	organic phosphonate transmembrane transporter activity
M9H61_RS12030	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
M9H61_RS12035	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
M9H61_RS12040	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
M9H61_RS12050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M9H61_RS12065	COG0039	L-malate dehydrogenase activity
M9H61_RS12070	COG1250	3-hydroxyacyl-CoA dehydrogenase
M9H61_RS12075	COG3246	L-lysine catabolic process to acetate
M9H61_RS12080	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS12090	COG0411	ABC transporter
M9H61_RS12100	COG0559	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS12110	COG1802	Transcriptional regulator
M9H61_RS12190	COG2948	multi-organism process
M9H61_RS12200	COG4962	Type ii secretion system protein e
M9H61_RS12235	COG5002	protein histidine kinase activity
M9H61_RS12260	COG2132	Multicopper oxidase
M9H61_RS12285	COG0531	amino acid
M9H61_RS12330	COG0584	glycerophosphoryl diester phosphodiesterase
M9H61_RS12335	COG0534	Mate efflux family protein
M9H61_RS12350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M9H61_RS12355	COG3001	Fructosamine kinase
M9H61_RS12365	COG0302	gtp cyclohydrolase
M9H61_RS12380	COG0398	Pfam SNARE associated Golgi protein
M9H61_RS12395	COG2818	Glycosylase
M9H61_RS12405	COG1309	transcriptional regulator
M9H61_RS12410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M9H61_RS12425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M9H61_RS12435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M9H61_RS12450	COG4774	siderophore transport
M9H61_RS12470	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M9H61_RS12505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M9H61_RS12510	COG2226	methyltransferase
M9H61_RS12520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M9H61_RS12525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M9H61_RS12525	COG0512	Glutamine amidotransferase of anthranilate synthase
M9H61_RS12535	COG3237	CsbD-like
M9H61_RS12550	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M9H61_RS12575	COG1749	Flagellar hook protein flgE
M9H61_RS12610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M9H61_RS12615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M9H61_RS12635	COG2171	N-acyltransferase activity
M9H61_RS12640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M9H61_RS12655	COG0625	glutathione transferase activity
M9H61_RS12660	COG0583	DNA-binding transcription factor activity
M9H61_RS12675	COG2816	NAD+ diphosphatase activity
M9H61_RS12685	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M9H61_RS12690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M9H61_RS12695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M9H61_RS12710	COG1802	Transcriptional regulator
M9H61_RS12715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M9H61_RS12720	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS12730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M9H61_RS12770	COG2205	protein histidine kinase activity
M9H61_RS12775	COG1078	dGTPase activity
M9H61_RS12785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M9H61_RS12795	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS12800	COG2721	sulfolactate sulfo-lyase activity
M9H61_RS12820	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M9H61_RS12825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M9H61_RS12830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M9H61_RS12835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M9H61_RS12835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M9H61_RS12845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M9H61_RS12850	COG0642	Histidine kinase
M9H61_RS12855	COG0745	RESPONSE REGULATOR receiver
M9H61_RS12865	COG2204	response regulator
M9H61_RS12870	COG2358	TRAP transporter, solute receptor (TAXI family
M9H61_RS12895	COG0583	DNA-binding transcription factor activity
M9H61_RS12905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M9H61_RS12915	COG0242	peptide deformylase activity
M9H61_RS12920	COG1322	Protein conserved in bacteria
M9H61_RS12925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M9H61_RS12930	COG0659	secondary active sulfate transmembrane transporter activity
M9H61_RS12935	COG0589	response to stress
M9H61_RS12950	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M9H61_RS12955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M9H61_RS12960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M9H61_RS12965	COG0842	Transport permease protein
M9H61_RS12970	COG2137	regulation of response to DNA damage stimulus
M9H61_RS12975	COG1393	Belongs to the ArsC family
M9H61_RS12985	COG1346	cytolysis
M9H61_RS13000	COG0137	argininosuccinate synthase activity
M9H61_RS13010	COG1280	lysine exporter protein (LysE YggA)
M9H61_RS13035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M9H61_RS13040	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M9H61_RS13050	COG1063	alcohol dehydrogenase
M9H61_RS13065	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M9H61_RS13070	COG1802	Transcriptional regulator
M9H61_RS13075	COG1312	Catalyzes the dehydration of D-mannonate
M9H61_RS13080	COG0246	Mannitol dehydrogenase
M9H61_RS13085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M9H61_RS13090	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M9H61_RS13135	COG2226	methyltransferase
M9H61_RS13160	COG1846	Transcriptional regulator
M9H61_RS13165	COG0438	transferase activity, transferring glycosyl groups
M9H61_RS13180	COG3842	ATPase activity
M9H61_RS13185	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M9H61_RS13200	COG4191	Histidine kinase
M9H61_RS13215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M9H61_RS13225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M9H61_RS13230	COG0268	Binds directly to 16S ribosomal RNA
M9H61_RS13235	COG1024	Enoyl-CoA hydratase
M9H61_RS13240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M9H61_RS13245	COG0730	response to heat
M9H61_RS13250	COG2814	Major facilitator Superfamily
M9H61_RS13255	COG0284	orotidine-5'-phosphate decarboxylase activity
M9H61_RS13265	COG0776	regulation of translation
M9H61_RS13270	COG0616	signal peptide processing
M9H61_RS13280	COG0539	negative regulation of cytoplasmic translation
M9H61_RS13305	COG2186	Transcriptional regulator
M9H61_RS13310	COG0179	Fumarylacetoacetate (FAA) hydrolase
M9H61_RS13315	COG2358	TRAP transporter, solute receptor (TAXI family
M9H61_RS13320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS13330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M9H61_RS13340	COG2391	methyltransferase activity
M9H61_RS13350	COG0519	Catalyzes the synthesis of GMP from XMP
M9H61_RS13350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M9H61_RS13370	COG1234	tRNA 3'-trailer cleavage
M9H61_RS13380	COG2983	Belongs to the UPF0260 family
M9H61_RS13390	COG1999	signal sequence binding
M9H61_RS13405	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
M9H61_RS13450	COG1492	cobalamin metabolic process
M9H61_RS13495	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M9H61_RS13500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M9H61_RS13525	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M9H61_RS13530	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
M9H61_RS13560	COG2308	Evidence 4 Homologs of previously reported genes of
M9H61_RS13570	COG1305	Transglutaminase-like
M9H61_RS13585	COG1268	BioY protein
M9H61_RS13590	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M9H61_RS13640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M9H61_RS13645	COG1120	ATPase activity
M9H61_RS13650	COG4303	Ethanolamine ammonia lyase large subunit
M9H61_RS13655	COG4302	ethanolamine ammonia-lyase activity
M9H61_RS13660	COG1592	Rubrerythrin
M9H61_RS13680	COG1185	polyribonucleotide nucleotidyltransferase activity
M9H61_RS13685	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M9H61_RS13690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M9H61_RS13695	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M9H61_RS13725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9H61_RS13730	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
M9H61_RS13740	COG1629	transport
M9H61_RS13740	COG4206	TonB-dependent receptor
M9H61_RS13750	COG1595	DNA-templated transcription, initiation
M9H61_RS13755	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M9H61_RS13760	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M9H61_RS13765	COG1396	sequence-specific DNA binding
M9H61_RS13770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M9H61_RS13785	COG1702	phosphate starvation-inducible protein PhoH
M9H61_RS13820	COG1214	PFAM Peptidase M22, glycoprotease
M9H61_RS13825	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
M9H61_RS13835	COG0395	ABC-type sugar transport system, permease component
M9H61_RS13840	COG1175	transmembrane transport
M9H61_RS13845	COG1653	transport
M9H61_RS13850	COG2723	6-phospho-beta-galactosidase activity
M9H61_RS13855	COG1609	Transcriptional regulator
M9H61_RS13860	COG1285	pathogenesis
M9H61_RS13870	COG1280	lysine exporter protein (LysE YggA)
M9H61_RS13880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M9H61_RS13890	COG1959	2 iron, 2 sulfur cluster binding
M9H61_RS13895	COG0756	dUTP diphosphatase activity
M9H61_RS13900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M9H61_RS13915	COG5002	protein histidine kinase activity
M9H61_RS13925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M9H61_RS13935	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M9H61_RS13955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M9H61_RS13965	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M9H61_RS14000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M9H61_RS14010	COG0583	DNA-binding transcription factor activity
M9H61_RS14015	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS14020	COG0456	acetyltransferase
M9H61_RS14040	COG0606	chelatase, subunit chli
M9H61_RS14055	COG1846	Transcriptional regulator
M9H61_RS14070	COG0625	glutathione transferase activity
M9H61_RS14115	COG0697	spore germination
M9H61_RS14135	COG1476	TRANSCRIPTIONal
M9H61_RS14150	COG3030	protein affecting phage T7 exclusion by the F plasmid
M9H61_RS14155	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M9H61_RS14160	COG1981	membrane
M9H61_RS14175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M9H61_RS14195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M9H61_RS14215	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M9H61_RS14225	COG0583	DNA-binding transcription factor activity
M9H61_RS14235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M9H61_RS14245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M9H61_RS14250	COG1331	Highly conserved protein containing a thioredoxin domain
M9H61_RS14260	COG3411	Ferredoxin
M9H61_RS14265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M9H61_RS14270	COG0445	tRNA wobble uridine modification
M9H61_RS14325	COG0352	thiamine-phosphate diphosphorylase activity
M9H61_RS14330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M9H61_RS14335	COG0745	RESPONSE REGULATOR receiver
M9H61_RS14350	COG0180	Tryptophanyl-tRNA synthetase
M9H61_RS14365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M9H61_RS14375	COG0280	phosphate acetyltransferase
M9H61_RS14375	COG0281	malic enzyme
M9H61_RS14390	COG2992	FlgJ-related protein
M9H61_RS14395	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M9H61_RS14410	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M9H61_RS14415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M9H61_RS14425	COG0583	DNA-binding transcription factor activity
M9H61_RS14460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M9H61_RS14465	COG1420	regulation of RNA biosynthetic process
M9H61_RS14470	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M9H61_RS14475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M9H61_RS14480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M9H61_RS14495	COG0517	IMP dehydrogenase activity
M9H61_RS14495	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M9H61_RS14510	COG1137	ATPase activity
M9H61_RS14515	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M9H61_RS14520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M9H61_RS14525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M9H61_RS14530	COG2211	Major facilitator Superfamily
M9H61_RS14535	COG1217	gtp-binding protein TYPA
M9H61_RS14540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M9H61_RS14570	COG0792	nuclease activity
M9H61_RS14575	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M9H61_RS14585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M9H61_RS14605	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M9H61_RS14615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M9H61_RS14615	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M9H61_RS14630	COG0285	dihydrofolate synthase activity
M9H61_RS14635	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M9H61_RS14645	COG0133	tryptophan synthase activity
M9H61_RS14655	COG1131	(ABC) transporter
M9H61_RS14660	COG2267	carboxylic ester hydrolase activity
M9H61_RS14680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M9H61_RS14685	COG0028	Belongs to the TPP enzyme family
M9H61_RS14700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M9H61_RS14705	COG0601	transmembrane transport
M9H61_RS14720	COG4172	Belongs to the ABC transporter superfamily
M9H61_RS14740	COG4566	intracellular signal transduction
M9H61_RS14745	COG2203	Gaf domain
M9H61_RS14745	COG3706	GGDEF domain
M9H61_RS14745	COG4251	negative regulation of phosphorylation
M9H61_RS14745	COG5001	Diguanylate cyclase
M9H61_RS14755	COG3852	Histidine kinase
M9H61_RS14770	COG1741	Belongs to the pirin family
M9H61_RS14815	COG1595	DNA-templated transcription, initiation
M9H61_RS14825	COG3842	ATPase activity
M9H61_RS14840	COG4208	sulfate ABC transporter
M9H61_RS14850	COG2186	Transcriptional regulator
M9H61_RS14855	COG0730	response to heat
M9H61_RS14860	COG3181	Tripartite tricarboxylate transporter family receptor
M9H61_RS14885	COG3416	Protein conserved in bacteria
M9H61_RS14885	COG2943	transferase activity, transferring hexosyl groups
M9H61_RS14895	COG0300	oxidoreductase activity
M9H61_RS14900	COG1024	Enoyl-CoA hydratase
M9H61_RS14910	COG1960	acyl-CoA dehydrogenase activity
M9H61_RS14915	COG1250	3-hydroxyacyl-CoA dehydrogenase
M9H61_RS14915	COG1024	Enoyl-CoA hydratase
M9H61_RS14920	COG0183	Belongs to the thiolase family
M9H61_RS14925	COG0789	Transcriptional regulator
M9H61_RS14930	COG0318	PFAM AMP-dependent synthetase and ligase
M9H61_RS14935	COG2067	long-chain fatty acid transport protein
M9H61_RS14960	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M9H61_RS14970	COG2807	transmembrane transport
M9H61_RS14980	COG4771	TonB-dependent receptor
M9H61_RS14985	COG3720	iron ion transport
M9H61_RS14990	COG4558	Periplasmic binding protein
M9H61_RS14995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M9H61_RS15000	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M9H61_RS15005	COG0840	transmembrane signaling receptor activity
M9H61_RS15010	COG0583	DNA-binding transcription factor activity
M9H61_RS15020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M9H61_RS15025	COG1012	belongs to the aldehyde dehydrogenase family
M9H61_RS15040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M9H61_RS15050	COG0352	thiamine-phosphate diphosphorylase activity
M9H61_RS15060	COG2183	response to ionizing radiation
M9H61_RS15075	COG0243	molybdopterin cofactor binding
M9H61_RS15080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M9H61_RS15085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M9H61_RS15085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M9H61_RS15090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M9H61_RS15100	COG5383	Protein conserved in bacteria
M9H61_RS15105	COG0138	bifunctional purine biosynthesis protein purh
M9H61_RS15110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M9H61_RS15115	COG1120	ATPase activity
M9H61_RS15120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M9H61_RS15125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M9H61_RS15130	COG4607	ABC-type enterochelin transport system periplasmic component
M9H61_RS15150	COG0181	hydroxymethylbilane synthase activity
M9H61_RS15160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M9H61_RS15165	COG2350	Protein conserved in bacteria
M9H61_RS15185	COG0438	transferase activity, transferring glycosyl groups
M9H61_RS15195	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M9H61_RS15205	COG0679	Auxin Efflux Carrier
M9H61_RS15210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M9H61_RS15215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M9H61_RS15220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M9H61_RS15225	COG0072	phenylalanine-tRNA ligase activity
M9H61_RS15235	COG4251	negative regulation of phosphorylation
M9H61_RS15250	COG4702	Belongs to the UPF0303 family
M9H61_RS15255	COG1733	regulation of RNA biosynthetic process
M9H61_RS15280	COG0802	atpase or kinase
M9H61_RS15290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M9H61_RS15300	COG1074	ATP-dependent DNA helicase activity
M9H61_RS15320	COG3069	C4-dicarboxylate transmembrane transporter activity
M9H61_RS15325	COG0840	transmembrane signaling receptor activity
M9H61_RS15330	COG1674	ftsk spoiiie
M9H61_RS15335	COG0436	Aminotransferase
M9H61_RS15340	COG0004	ammonium transporteR
M9H61_RS15345	COG0004	ammonium transporteR
M9H61_RS15355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M9H61_RS15360	COG3047	cAMP biosynthetic process
M9H61_RS15370	COG2835	tetraacyldisaccharide 4'-kinase activity
M9H61_RS15380	COG3118	belongs to the thioredoxin family
M9H61_RS15405	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M9H61_RS15410	COG2902	Dehydrogenase
M9H61_RS15420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9H61_RS15435	COG0501	Belongs to the peptidase M48B family
M9H61_RS15445	COG0670	Belongs to the BI1 family
M9H61_RS15455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M9H61_RS15460	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M9H61_RS15465	COG4181	ATPase activity
M9H61_RS15485	COG0667	Aldo Keto reductase
M9H61_RS15490	COG1741	Belongs to the pirin family
M9H61_RS15495	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M9H61_RS15500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M9H61_RS15510	COG0697	spore germination
M9H61_RS15515	COG1846	Transcriptional regulator
M9H61_RS15540	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M9H61_RS15545	COG0210	DNA helicase
M9H61_RS15565	COG0604	alcohol dehydrogenase
M9H61_RS15565	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS15565	COG3321	synthase
M9H61_RS15580	COG0583	DNA-binding transcription factor activity
M9H61_RS15585	COG4166	transmembrane transport
M9H61_RS15590	COG4174	ABC transporter (Permease)
M9H61_RS15595	COG4239	(ABC) transporter, permease
M9H61_RS15600	COG4172	Belongs to the ABC transporter superfamily
M9H61_RS15610	COG1280	lysine exporter protein (LysE YggA)
M9H61_RS15620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M9H61_RS15625	COG2819	hydrolase of the alpha beta superfamily
M9H61_RS15635	COG1573	uracil-dna glycosylase
M9H61_RS15640	COG2154	pterin-4-alpha-carbinolamine dehydratase
M9H61_RS15660	COG0697	spore germination
M9H61_RS15665	COG1522	sequence-specific DNA binding
M9H61_RS15700	COG3474	cytochrome
M9H61_RS15705	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M9H61_RS15720	COG0513	Belongs to the DEAD box helicase family
M9H61_RS15745	COG1960	acyl-CoA dehydrogenase activity
M9H61_RS15750	COG0183	Belongs to the thiolase family
M9H61_RS15755	COG0288	reversible hydration of carbon dioxide
M9H61_RS15760	COG1960	acyl-CoA dehydrogenase activity
M9H61_RS15775	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M9H61_RS15780	COG1842	Phage shock protein A
M9H61_RS15835	COG1566	PFAM secretion protein HlyD family protein
M9H61_RS15840	COG2301	Belongs to the HpcH HpaI aldolase family
M9H61_RS15845	COG2030	dehydratase
M9H61_RS15865	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M9H61_RS15875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M9H61_RS15885	COG4266	Belongs to the allantoicase family
M9H61_RS15910	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M9H61_RS15910	COG2010	Cytochrome c
M9H61_RS15920	COG0590	tRNA wobble adenosine to inosine editing
M9H61_RS15925	COG3845	ABC transporter
M9H61_RS15975	COG0583	DNA-binding transcription factor activity
M9H61_RS16010	COG0411	ABC transporter
M9H61_RS16020	COG0829	nickel cation binding
M9H61_RS16025	COG0831	urea catabolic process
M9H61_RS16030	COG0832	Belongs to the urease beta subunit family
M9H61_RS16035	COG0804	urea catabolic process
M9H61_RS16045	COG0830	nickel cation binding
M9H61_RS16050	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M9H61_RS16060	COG0640	Transcriptional regulator
M9H61_RS16065	COG1268	BioY protein
M9H61_RS16070	COG1122	ATPase activity
M9H61_RS16075	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M9H61_RS16085	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M9H61_RS16090	COG0583	DNA-binding transcription factor activity
M9H61_RS16110	COG2226	methyltransferase
M9H61_RS16135	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS16160	COG2239	Acts as a magnesium transporter
M9H61_RS16165	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
M9H61_RS16175	COG2095	MarC family integral membrane protein
M9H61_RS16185	COG0501	Belongs to the peptidase M48B family
M9H61_RS16195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9H61_RS16220	COG1703	isobutyryl-CoA mutase activity
M9H61_RS16240	COG3186	Phenylalanine-4-hydroxylase
M9H61_RS16245	COG1522	sequence-specific DNA binding
M9H61_RS16255	COG1742	UPF0060 membrane protein
M9H61_RS16265	COG2204	response regulator
M9H61_RS16270	COG2207	Transcriptional regulator
M9H61_RS16270	COG4753	response regulator
M9H61_RS16290	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M9H61_RS16295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M9H61_RS16340	COG0778	Nitroreductase
M9H61_RS16380	COG1968	undecaprenyl-diphosphatase activity
M9H61_RS16410	COG0747	negative chemotaxis
M9H61_RS16435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M9H61_RS16450	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M9H61_RS16455	COG0277	FAD linked oxidase domain protein
M9H61_RS16460	COG0277	FAD linked oxidase domain protein
M9H61_RS16465	COG0247	lactate metabolic process
M9H61_RS16475	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M9H61_RS16480	COG0573	inorganic phosphate transmembrane transporter activity
M9H61_RS16485	COG0581	inorganic phosphate transmembrane transporter activity
M9H61_RS16500	COG0745	RESPONSE REGULATOR receiver
M9H61_RS16515	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS16520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M9H61_RS16530	COG2233	PERMEase
M9H61_RS16535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M9H61_RS16560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M9H61_RS16575	COG0287	Prephenate dehydrogenase
M9H61_RS16640	COG2884	Cell division ATP-binding protein ftsE
M9H61_RS16655	COG0019	diaminopimelate decarboxylase activity
M9H61_RS16670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M9H61_RS16680	COG1070	Carbohydrate kinase
M9H61_RS16685	COG1250	3-hydroxyacyl-CoA dehydrogenase
M9H61_RS16700	COG2096	Adenosyltransferase
M9H61_RS16710	COG3604	Transcriptional regulator
M9H61_RS16715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M9H61_RS16720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M9H61_RS16725	COG1116	anion transmembrane transporter activity
M9H61_RS16730	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
M9H61_RS16735	COG0625	glutathione transferase activity
M9H61_RS16755	COG0604	alcohol dehydrogenase
M9H61_RS16760	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M9H61_RS16760	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M9H61_RS16775	COG0328	RNA-DNA hybrid ribonuclease activity
M9H61_RS16785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M9H61_RS16795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M9H61_RS16800	COG0509	glycine decarboxylation via glycine cleavage system
M9H61_RS16805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M9H61_RS16810	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M9H61_RS16825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M9H61_RS16825	COG0678	peroxiredoxin activity
M9H61_RS16835	COG1678	Uncharacterized ACR, COG1678
M9H61_RS16845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M9H61_RS16850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M9H61_RS16855	COG0109	protoheme IX farnesyltransferase activity
M9H61_RS16865	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M9H61_RS16885	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M9H61_RS16890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M9H61_RS16900	COG0612	Peptidase, M16
M9H61_RS16905	COG1940	carbohydrate kinase activity
M9H61_RS16925	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M9H61_RS16940	COG1473	amidohydrolase
M9H61_RS16955	COG0583	DNA-binding transcription factor activity
M9H61_RS16965	COG1012	belongs to the aldehyde dehydrogenase family
M9H61_RS16975	COG1573	uracil-dna glycosylase
M9H61_RS16980	COG0741	lytic transglycosylase activity
M9H61_RS16995	COG3088	subunit of a heme lyase
M9H61_RS17000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M9H61_RS17005	COG1138	Cytochrome C-type biogenesis protein
M9H61_RS17010	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M9H61_RS17020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M9H61_RS17025	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M9H61_RS17040	COG0733	neurotransmitter:sodium symporter activity
M9H61_RS17045	COG3300	MHYT domain
M9H61_RS17045	COG5001	Diguanylate cyclase
M9H61_RS17085	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M9H61_RS17090	COG0701	Predicted permease
M9H61_RS17110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M9H61_RS17110	COG2111	Na H antiporter
M9H61_RS17115	COG1006	Multisubunit Na H antiporter MnhC subunit
M9H61_RS17120	COG0651	ATP synthesis coupled electron transport
M9H61_RS17125	COG1863	multisubunit Na H antiporter MnhE subunit
M9H61_RS17130	COG2212	antiporter activity
M9H61_RS17135	COG1320	monovalent cation:proton antiporter activity
M9H61_RS17140	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M9H61_RS17155	COG2832	Protein of unknown function (DUF454)
M9H61_RS17165	COG4251	negative regulation of phosphorylation
M9H61_RS17225	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M9H61_RS17240	COG0583	DNA-binding transcription factor activity
M9H61_RS17245	COG1960	acyl-CoA dehydrogenase activity
M9H61_RS17250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M9H61_RS17255	COG3842	ATPase activity
M9H61_RS17265	COG1177	transmembrane transport
M9H61_RS17280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M9H61_RS17310	COG2207	Transcriptional regulator
M9H61_RS17355	COG3300	MHYT domain
M9H61_RS17355	COG5001	Diguanylate cyclase
M9H61_RS17360	COG4942	peptidase
M9H61_RS17370	COG2226	methyltransferase
M9H61_RS17375	COG2030	dehydratase
M9H61_RS17380	COG0196	riboflavin kinase activity
M9H61_RS17390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M9H61_RS17400	COG0612	Peptidase, M16
M9H61_RS17405	COG0612	Peptidase, M16
M9H61_RS17410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M9H61_RS17420	COG1360	Flagellar Motor Protein
M9H61_RS17425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M9H61_RS17445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M9H61_RS17450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M9H61_RS17450	COG1321	iron dependent repressor
M9H61_RS17455	COG1121	(ABC) transporter
M9H61_RS17460	COG0803	Belongs to the bacterial solute-binding protein 9 family
M9H61_RS17465	COG1321	iron dependent repressor
M9H61_RS17475	COG2264	protein methyltransferase activity
M9H61_RS17480	COG0438	transferase activity, transferring glycosyl groups
M9H61_RS17505	COG0107	imidazoleglycerol-phosphate synthase activity
M9H61_RS17515	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M9H61_RS17520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M9H61_RS17525	COG2089	acid synthase
M9H61_RS17535	COG1083	cytidylyl-transferase
M9H61_RS17540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M9H61_RS17560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M9H61_RS17565	COG2089	acid synthase
M9H61_RS17570	COG1132	(ABC) transporter
M9H61_RS17600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M9H61_RS17605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M9H61_RS17615	COG0438	transferase activity, transferring glycosyl groups
M9H61_RS17630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M9H61_RS17635	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M9H61_RS17640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M9H61_RS17655	COG1396	sequence-specific DNA binding
M9H61_RS17680	COG3243	poly(R)-hydroxyalkanoic acid synthase
M9H61_RS17690	COG1522	sequence-specific DNA binding
M9H61_RS17700	COG2132	Multicopper oxidase
M9H61_RS17730	COG1072	(Pantothenic acid kinase))
M9H61_RS17755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M9H61_RS17770	COG1280	lysine exporter protein (LysE YggA)
M9H61_RS17790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M9H61_RS17795	COG0408	coproporphyrinogen oxidase activity
M9H61_RS17820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M9H61_RS17825	COG1846	Transcriptional regulator
M9H61_RS17830	COG0745	RESPONSE REGULATOR receiver
M9H61_RS17865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M9H61_RS17920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M9H61_RS17925	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M9H61_RS17935	COG0012	GTP binding
M9H61_RS17940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M9H61_RS17940	COG0519	Catalyzes the synthesis of GMP from XMP
M9H61_RS17945	COG1618	nucleotide phosphatase activity, acting on free nucleotides
M9H61_RS17945	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M9H61_RS17965	COG0450	alkyl hydroperoxide reductase
M9H61_RS17970	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M9H61_RS17980	COG0436	Aminotransferase
M9H61_RS17985	COG0556	nucleotide-excision repair
M9H61_RS17995	COG1914	H( )-stimulated, divalent metal cation uptake system
M9H61_RS18000	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M9H61_RS18005	COG0583	DNA-binding transcription factor activity
M9H61_RS18010	COG4336	lyase activity
M9H61_RS18025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS18035	COG0154	amidase activity
M9H61_RS18040	COG0783	Belongs to the Dps family
M9H61_RS18045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M9H61_RS18050	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M9H61_RS18055	COG0583	DNA-binding transcription factor activity
M9H61_RS18060	COG0492	ferredoxin-NADP+ reductase activity
M9H61_RS18065	COG1522	sequence-specific DNA binding
M9H61_RS18080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M9H61_RS18085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M9H61_RS18090	COG0505	Belongs to the CarA family
M9H61_RS18100	COG0358	DNA primase activity
M9H61_RS18105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M9H61_RS18135	COG2223	nitrite transmembrane transporter activity
M9H61_RS18140	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M9H61_RS18145	COG1140	nitrate reductase beta subunit
M9H61_RS18150	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M9H61_RS18155	COG2181	nitrate reductase activity
M9H61_RS18160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M9H61_RS18165	COG0288	reversible hydration of carbon dioxide
M9H61_RS18175	COG0826	peptidase U32
M9H61_RS18180	COG0826	peptidase U32
M9H61_RS18235	COG3901	Regulator of nitric oxide reductase transcription
M9H61_RS18235	COG0348	domain, Protein
M9H61_RS18245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M9H61_RS18260	COG2207	Transcriptional regulator
M9H61_RS18265	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M9H61_RS18270	COG2814	Major facilitator Superfamily
M9H61_RS18275	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
M9H61_RS18280	COG4221	oxidoreductase activity
M9H61_RS18285	COG4977	sequence-specific DNA binding
M9H61_RS18305	COG0583	DNA-binding transcription factor activity
M9H61_RS18340	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M9H61_RS18350	COG4191	Histidine kinase
M9H61_RS18355	COG4566	intracellular signal transduction
M9H61_RS18360	COG4566	intracellular signal transduction
M9H61_RS18365	COG0840	transmembrane signaling receptor activity
M9H61_RS18420	COG2358	TRAP transporter, solute receptor (TAXI family
M9H61_RS18425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS18430	COG0840	transmembrane signaling receptor activity
M9H61_RS18465	COG4585	Histidine kinase
M9H61_RS18475	COG1129	ABC transporter
M9H61_RS18480	COG1172	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS18485	COG1172	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS18495	COG1609	Transcriptional regulator
M9H61_RS18515	COG1879	ABC-type sugar transport system periplasmic component
M9H61_RS18520	COG1129	ABC transporter
M9H61_RS18525	COG1172	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS18530	COG1129	ABC transporter
M9H61_RS18555	COG0626	cystathionine gamma-synthase activity
M9H61_RS18570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M9H61_RS18595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M9H61_RS18600	COG1120	ATPase activity
M9H61_RS18605	COG4774	siderophore transport
M9H61_RS18635	COG0587	DNA-directed DNA polymerase activity
M9H61_RS18645	COG2201	protein-glutamate methylesterase activity
M9H61_RS18660	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
M9H61_RS18665	COG1132	(ABC) transporter
M9H61_RS18670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9H61_RS18680	COG0784	Response regulator, receiver
M9H61_RS18680	COG2205	protein histidine kinase activity
M9H61_RS18680	COG5002	protein histidine kinase activity
M9H61_RS18690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M9H61_RS18700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M9H61_RS18720	COG1175	transmembrane transport
M9H61_RS18725	COG3833	ABC-type maltose transport systems, permease component
M9H61_RS18730	COG3842	ATPase activity
M9H61_RS18740	COG3254	rhamnose metabolic process
M9H61_RS18755	COG2721	sulfolactate sulfo-lyase activity
M9H61_RS18760	COG2721	sulfolactate sulfo-lyase activity
M9H61_RS18765	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS18770	COG0179	Fumarylacetoacetate (FAA) hydrolase
M9H61_RS18790	COG0583	DNA-binding transcription factor activity
M9H61_RS18815	COG0473	3-isopropylmalate dehydrogenase activity
M9H61_RS18820	COG0583	DNA-binding transcription factor activity
M9H61_RS18825	COG4948	Mandelate Racemase Muconate Lactonizing
M9H61_RS18855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M9H61_RS18860	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M9H61_RS18865	COG0583	DNA-binding transcription factor activity
M9H61_RS18895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M9H61_RS18905	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M9H61_RS18910	COG4149	molybdate abc transporter
M9H61_RS18915	COG0725	ABC transporter, periplasmic molybdate-binding protein
M9H61_RS18935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M9H61_RS18945	COG0488	(ABC) transporter
M9H61_RS18955	COG2853	Lipoprotein
M9H61_RS18960	COG2226	methyltransferase
M9H61_RS18965	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M9H61_RS18975	COG1410	methionine synthase
M9H61_RS18975	COG0646	methionine synthase
M9H61_RS18980	COG2814	Major facilitator Superfamily
M9H61_RS18985	COG0038	chloride channel
M9H61_RS19005	COG0210	DNA helicase
M9H61_RS19010	COG2264	protein methyltransferase activity
M9H61_RS19015	COG0730	response to heat
M9H61_RS19030	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS19040	COG0006	proline dipeptidase activity
M9H61_RS19045	COG0667	Aldo Keto reductase
M9H61_RS19055	COG0697	spore germination
M9H61_RS19075	COG0497	DNA recombination
M9H61_RS19080	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M9H61_RS19090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M9H61_RS19095	COG0849	cell division
M9H61_RS19105	COG1175	transmembrane transport
M9H61_RS19125	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M9H61_RS19130	COG1181	Belongs to the D-alanine--D-alanine ligase family
M9H61_RS19135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M9H61_RS19140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M9H61_RS19155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M9H61_RS19170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M9H61_RS19205	COG1335	isochorismatase
M9H61_RS19220	COG3023	N-Acetylmuramoyl-L-alanine amidase
M9H61_RS19230	COG0488	(ABC) transporter
M9H61_RS19235	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M9H61_RS19245	COG0840	transmembrane signaling receptor activity
M9H61_RS19280	COG0069	glutamate synthase activity
M9H61_RS19290	COG3811	Belongs to the UPF0386 family
M9H61_RS19295	COG0454	-acetyltransferase
M9H61_RS19295	COG0456	acetyltransferase
M9H61_RS19305	COG0559	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS19315	COG0277	FAD linked oxidase domain protein
M9H61_RS19335	COG0306	phosphate transporter
M9H61_RS19340	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M9H61_RS19345	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M9H61_RS19350	COG0343	queuine tRNA-ribosyltransferase activity
M9H61_RS19355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M9H61_RS19360	COG1595	DNA-templated transcription, initiation
M9H61_RS19365	COG3712	iron ion homeostasis
M9H61_RS19375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M9H61_RS19380	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M9H61_RS19405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M9H61_RS19410	COG3246	L-lysine catabolic process to acetate
M9H61_RS19415	COG2358	TRAP transporter, solute receptor (TAXI family
M9H61_RS19435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M9H61_RS19445	COG3474	cytochrome
M9H61_RS19465	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M9H61_RS19480	COG0142	geranyltranstransferase activity
M9H61_RS19490	COG2890	protein-(glutamine-N5) methyltransferase activity
M9H61_RS19500	COG0752	glycyl-tRNA synthetase alpha subunit
M9H61_RS19510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M9H61_RS19510	COG0574	Belongs to the PEP-utilizing enzyme family
M9H61_RS19520	COG0354	folic acid binding
M9H61_RS19550	COG3339	Conserved Protein
M9H61_RS19555	COG0604	alcohol dehydrogenase
M9H61_RS19615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M9H61_RS19625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M9H61_RS19645	COG1530	ribonuclease E activity
M9H61_RS19650	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M9H61_RS19670	COG0415	Belongs to the DNA photolyase family
M9H61_RS19685	COG2313	pseudouridylate synthase activity
M9H61_RS19690	COG2814	Major facilitator Superfamily
M9H61_RS19695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M9H61_RS19700	COG0440	acetolactate synthase activity
M9H61_RS19705	COG0028	Belongs to the TPP enzyme family
M9H61_RS19715	COG0560	Phosphoserine phosphatase
M9H61_RS19715	COG3830	Belongs to the UPF0237 family
M9H61_RS19735	COG0330	HflC and HflK could
M9H61_RS19740	COG0489	protein tyrosine kinase activity
M9H61_RS19745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M9H61_RS19750	COG0047	phosphoribosylformylglycinamidine synthase activity
M9H61_RS19755	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M9H61_RS19760	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M9H61_RS19775	COG2197	response regulator
M9H61_RS19800	COG3473	Maleate cis-trans isomerase
M9H61_RS19805	COG1802	Transcriptional regulator
M9H61_RS19810	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M9H61_RS19815	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M9H61_RS19830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M9H61_RS19835	COG0601	transmembrane transport
M9H61_RS19840	COG4166	transmembrane transport
M9H61_RS19855	COG4771	TonB-dependent receptor
M9H61_RS19870	COG0346	lactoylglutathione lyase activity
M9H61_RS19875	COG2003	Belongs to the UPF0758 family
M9H61_RS19880	COG0024	Methionine aminopeptidase
M9H61_RS19885	COG1489	DNA binding
M9H61_RS19905	COG0625	glutathione transferase activity
M9H61_RS19960	COG1136	(ABC) transporter
M9H61_RS19970	COG1785	Belongs to the alkaline phosphatase family
M9H61_RS19975	COG2813	Specifically methylates the guanine in position
M9H61_RS19985	COG3920	Histidine kinase
M9H61_RS19985	COG2202	Pas domain
M9H61_RS19990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M9H61_RS20005	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
M9H61_RS20015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M9H61_RS20020	COG0124	histidyl-tRNA synthetase
M9H61_RS20025	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M9H61_RS20030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M9H61_RS20035	COG2890	protein-(glutamine-N5) methyltransferase activity
M9H61_RS20055	COG0542	response to heat
M9H61_RS20080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M9H61_RS20105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M9H61_RS20115	COG1566	PFAM secretion protein HlyD family protein
M9H61_RS20120	COG0242	peptide deformylase activity
M9H61_RS20135	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M9H61_RS20140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M9H61_RS20195	COG1349	DNA-binding transcription factor activity
M9H61_RS20205	COG0604	alcohol dehydrogenase
M9H61_RS20205	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS20205	COG3321	synthase
M9H61_RS20230	COG0254	rRNA binding
M9H61_RS20240	COG1132	(ABC) transporter
M9H61_RS20245	COG0739	heme binding
M9H61_RS20245	COG0741	lytic transglycosylase activity
M9H61_RS20245	COG1196	nuclear chromosome segregation
M9H61_RS20285	COG1024	Enoyl-CoA hydratase
M9H61_RS20285	COG1250	3-hydroxyacyl-CoA dehydrogenase
M9H61_RS20295	COG1902	pentaerythritol trinitrate reductase activity
M9H61_RS20300	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS20315	COG1960	acyl-CoA dehydrogenase activity
M9H61_RS20330	COG3483	tryptophan 2,3-dioxygenase activity
M9H61_RS20340	COG0559	Belongs to the binding-protein-dependent transport system permease family
M9H61_RS20350	COG0411	ABC transporter
M9H61_RS20370	COG2204	response regulator
M9H61_RS20375	COG4191	Histidine kinase
M9H61_RS20385	COG2223	nitrite transmembrane transporter activity
M9H61_RS20390	COG0583	DNA-binding transcription factor activity
M9H61_RS20405	COG3383	formate dehydrogenase (NAD+) activity
M9H61_RS20420	COG1609	Transcriptional regulator
M9H61_RS20445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M9H61_RS20455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M9H61_RS20475	COG4214	carbohydrate transport
M9H61_RS20480	COG4213	ABC transporter substrate-binding protein
M9H61_RS20485	COG1028	Short-chain dehydrogenase reductase Sdr
M9H61_RS20490	COG0129	dihydroxy-acid dehydratase activity
M9H61_RS20495	COG1538	Outer membrane efflux protein
M9H61_RS20500	COG0577	efflux transmembrane transporter activity
M9H61_RS20500	COG1136	(ABC) transporter
M9H61_RS20505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M9H61_RS20510	COG0745	RESPONSE REGULATOR receiver
M9H61_RS20515	COG2205	protein histidine kinase activity
M9H61_RS20525	COG0174	glutamine synthetase
M9H61_RS20530	COG0069	glutamate synthase activity
M9H61_RS20535	COG2218	PFAM glutamate synthase alpha subunit domain protein
M9H61_RS20540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M9H61_RS20555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M9H61_RS20580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M9H61_RS20595	COG4977	sequence-specific DNA binding
M9H61_RS20600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M9H61_RS20605	COG4311	Sarcosine oxidase, delta subunit
M9H61_RS20610	COG0446	pyridine nucleotide-disulphide oxidoreductase
M9H61_RS20610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M9H61_RS20625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls