locus-tag	class	description
TH3_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TH3_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TH3_RS00025	COG1216	Glycosyl transferase, family 2
TH3_RS00035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TH3_RS00070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TH3_RS00075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TH3_RS00080	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TH3_RS00110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TH3_RS00115	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TH3_RS00145	COG1280	lysine exporter protein (LysE YggA)
TH3_RS00155	COG0137	argininosuccinate synthase activity
TH3_RS00160	COG0101	tRNA pseudouridine synthase activity
TH3_RS00170	COG1346	cytolysis
TH3_RS00180	COG1393	Belongs to the ArsC family
TH3_RS00190	COG2137	regulation of response to DNA damage stimulus
TH3_RS00195	COG0842	Transport permease protein
TH3_RS00200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TH3_RS00205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TH3_RS00210	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TH3_RS00230	COG1595	DNA-templated transcription, initiation
TH3_RS00240	COG0589	response to stress
TH3_RS00245	COG0659	secondary active sulfate transmembrane transporter activity
TH3_RS00250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TH3_RS00255	COG1322	Protein conserved in bacteria
TH3_RS00260	COG0242	peptide deformylase activity
TH3_RS00280	COG0583	DNA-binding transcription factor activity
TH3_RS00305	COG2358	TRAP transporter, solute receptor (TAXI family
TH3_RS00310	COG2204	response regulator
TH3_RS00315	COG4191	Histidine kinase
TH3_RS00320	COG0745	RESPONSE REGULATOR receiver
TH3_RS00325	COG0642	Histidine kinase
TH3_RS00330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TH3_RS00335	COG1660	Displays ATPase and GTPase activities
TH3_RS00340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TH3_RS00340	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TH3_RS00350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TH3_RS00355	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TH3_RS00380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TH3_RS00390	COG1078	dGTPase activity
TH3_RS00395	COG2205	protein histidine kinase activity
TH3_RS00430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_RS00450	COG1802	Transcriptional regulator
TH3_RS00460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TH3_RS00470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TH3_RS00475	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TH3_RS00480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TH3_RS00490	COG2816	NAD+ diphosphatase activity
TH3_RS00505	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
TH3_RS00510	COG0583	DNA-binding transcription factor activity
TH3_RS00520	COG0625	glutathione transferase activity
TH3_RS00530	COG3128	pkhd-type hydroxylase
TH3_RS00535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TH3_RS00540	COG2171	N-acyltransferase activity
TH3_RS00550	COG2200	EAL domain
TH3_RS00550	COG2199	diguanylate cyclase activity
TH3_RS00560	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TH3_RS00575	COG3237	CsbD-like
TH3_RS00585	COG0512	Glutamine amidotransferase of anthranilate synthase
TH3_RS00585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TH3_RS00590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TH3_RS00605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TH3_RS00625	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TH3_RS00645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TH3_RS00655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TH3_RS00670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TH3_RS00685	COG2818	Glycosylase
TH3_RS00690	COG5002	protein histidine kinase activity
TH3_RS00700	COG0398	Pfam SNARE associated Golgi protein
TH3_RS00715	COG0302	gtp cyclohydrolase
TH3_RS00720	COG3001	Fructosamine kinase
TH3_RS00725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TH3_RS00740	COG0534	Mate efflux family protein
TH3_RS00745	COG0584	glycerophosphoryl diester phosphodiesterase
TH3_RS00795	COG4191	Histidine kinase
TH3_RS00810	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TH3_RS00815	COG3842	ATPase activity
TH3_RS00855	COG1205	dead DEAH box helicase
TH3_RS00855	COG1111	helicase
TH3_RS00860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TH3_RS00930	COG4962	Type ii secretion system protein e
TH3_RS00940	COG2948	multi-organism process
TH3_RS01035	COG0419	ATPase involved in DNA repair
TH3_RS01040	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TH3_RS01045	COG0039	L-malate dehydrogenase activity
TH3_RS01050	COG0657	acetylesterase activity
TH3_RS01060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TH3_RS01070	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TH3_RS01075	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TH3_RS01080	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TH3_RS01085	COG3639	organic phosphonate transmembrane transporter activity
TH3_RS01095	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
TH3_RS01100	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TH3_RS01100	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
TH3_RS01105	COG3454	Phosphonate metabolism
TH3_RS01110	COG4778	phosphonate C-P lyase system protein PhnL
TH3_RS01115	COG4107	phosphonate C-P lyase system protein PhnK
TH3_RS01120	COG3627	carbon phosphorus lyase activity
TH3_RS01125	COG3626	phosphonate metabolism
TH3_RS01135	COG3624	Phosphonate C-P lyase system protein PhnG
TH3_RS01140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TH3_RS01150	COG5001	Diguanylate cyclase
TH3_RS01155	COG0024	Methionine aminopeptidase
TH3_RS01160	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TH3_RS01175	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_RS01190	COG2081	HI0933 family
TH3_RS01195	COG3706	GGDEF domain
TH3_RS01225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TH3_RS01230	COG3806	Anti-sigma factor
TH3_RS01235	COG1595	DNA-templated transcription, initiation
TH3_RS01250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TH3_RS01255	COG2190	(PTS) system
TH3_RS01255	COG2211	Major facilitator Superfamily
TH3_RS01270	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS01285	COG0564	pseudouridine synthase activity
TH3_RS01305	COG1803	Methylglyoxal synthase
TH3_RS01325	COG0508	dehydrogenase complex catalyzes the overall conversion of
TH3_RS01335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TH3_RS01340	COG0045	succinate-CoA ligase (ADP-forming) activity
TH3_RS01345	COG0039	L-malate dehydrogenase activity
TH3_RS01355	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TH3_RS01365	COG1196	nuclear chromosome segregation
TH3_RS01365	COG3264	Mechanosensitive ion channel
TH3_RS01370	COG0494	nUDIX hydrolase
TH3_RS01380	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TH3_RS01400	COG0174	glutamine synthetase
TH3_RS01410	COG0625	glutathione transferase activity
TH3_RS01420	COG4974	Belongs to the 'phage' integrase family
TH3_RS01430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TH3_RS01455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TH3_RS01480	COG0784	Response regulator, receiver
TH3_RS01485	COG4235	cytochrome complex assembly
TH3_RS01490	COG1138	Cytochrome C-type biogenesis protein
TH3_RS01495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TH3_RS01500	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TH3_RS01505	COG1702	phosphate starvation-inducible protein PhoH
TH3_RS01515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TH3_RS01555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_RS01560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TH3_RS01580	COG0519	Catalyzes the synthesis of GMP from XMP
TH3_RS01590	COG1872	DUF167
TH3_RS01595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TH3_RS01605	COG3273	potassium ion transport
TH3_RS01605	COG0471	metal ion transport
TH3_RS01610	COG3214	Protein conserved in bacteria
TH3_RS01615	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS01625	COG0395	ABC-type sugar transport system, permease component
TH3_RS01655	COG4774	siderophore transport
TH3_RS01675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TH3_RS01680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TH3_RS01695	COG1595	DNA-templated transcription, initiation
TH3_RS01710	COG0066	3-isopropylmalate dehydratase activity
TH3_RS01720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TH3_RS01740	COG0228	four-way junction DNA binding
TH3_RS01745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TH3_RS01760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TH3_RS01770	COG2217	Heavy metal translocating P-type atpase
TH3_RS01785	COG2010	Cytochrome c
TH3_RS01805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TH3_RS01810	COG0126	phosphoglycerate kinase activity
TH3_RS01830	COG2267	carboxylic ester hydrolase activity
TH3_RS01835	COG4106	trans-aconitate 2-methyltransferase activity
TH3_RS01845	COG1051	belongs to the nudix hydrolase family
TH3_RS01855	COG0793	Belongs to the peptidase S41A family
TH3_RS01860	COG4942	peptidase
TH3_RS01865	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TH3_RS01870	COG1760	l-serine dehydratase
TH3_RS01875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TH3_RS01890	COG0799	negative regulation of ribosome biogenesis
TH3_RS01895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TH3_RS01905	COG5265	(ABC) transporter
TH3_RS01925	COG3706	GGDEF domain
TH3_RS01945	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TH3_RS01955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TH3_RS01960	COG0402	S-adenosylhomocysteine deaminase activity
TH3_RS01970	COG4603	Belongs to the binding-protein-dependent transport system permease family
TH3_RS01975	COG3845	ABC transporter
TH3_RS01980	COG1744	ABC transporter substrate-binding protein PnrA-like
TH3_RS01995	COG1194	a g-specific adenine glycosylase
TH3_RS02005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TH3_RS02005	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TH3_RS02010	COG1196	nuclear chromosome segregation
TH3_RS02040	COG0435	Glutathione S-transferase
TH3_RS02045	COG0583	DNA-binding transcription factor activity
TH3_RS02065	COG0714	Associated with various cellular activities
TH3_RS02085	COG0617	tRNA 3'-terminal CCA addition
TH3_RS02100	COG2202	Pas domain
TH3_RS02100	COG2200	EAL domain
TH3_RS02100	COG2199	diguanylate cyclase activity
TH3_RS02105	COG4974	Belongs to the 'phage' integrase family
TH3_RS02125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TH3_RS02130	COG4536	flavin adenine dinucleotide binding
TH3_RS02135	COG0517	IMP dehydrogenase activity
TH3_RS02160	COG0271	Belongs to the BolA IbaG family
TH3_RS02180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TH3_RS02205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TH3_RS02215	COG4774	siderophore transport
TH3_RS02225	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TH3_RS02230	COG1238	metal cluster binding
TH3_RS02245	COG1454	alcohol dehydrogenase
TH3_RS02250	COG1012	belongs to the aldehyde dehydrogenase family
TH3_RS02255	COG1454	alcohol dehydrogenase
TH3_RS02265	COG1129	ABC transporter
TH3_RS02290	COG2204	response regulator
TH3_RS02300	COG1063	alcohol dehydrogenase
TH3_RS02315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_RS02320	COG1802	Transcriptional regulator
TH3_RS02325	COG1312	Catalyzes the dehydration of D-mannonate
TH3_RS02330	COG0246	Mannitol dehydrogenase
TH3_RS02350	COG2814	Major facilitator Superfamily
TH3_RS02360	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TH3_RS02370	COG3842	ATPase activity
TH3_RS02390	COG1609	Transcriptional regulator
TH3_RS02395	COG2205	protein histidine kinase activity
TH3_RS02400	COG0745	RESPONSE REGULATOR receiver
TH3_RS02405	COG0746	molybdenum cofactor guanylyltransferase activity
TH3_RS02425	COG1522	sequence-specific DNA binding
TH3_RS02455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_RS02470	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
TH3_RS02480	COG0625	glutathione transferase activity
TH3_RS02500	COG0019	diaminopimelate decarboxylase activity
TH3_RS02510	COG1309	transcriptional regulator
TH3_RS02520	COG1609	Transcriptional regulator
TH3_RS02525	COG1129	ABC transporter
TH3_RS02530	COG1172	Belongs to the binding-protein-dependent transport system permease family
TH3_RS02535	COG1879	ABC-type sugar transport system periplasmic component
TH3_RS02545	COG0673	inositol 2-dehydrogenase activity
TH3_RS02560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_RS02575	COG0154	amidase activity
TH3_RS02610	COG1522	sequence-specific DNA binding
TH3_RS02615	COG3608	succinylglutamate desuccinylase aspartoacylase
TH3_RS02620	COG0006	proline dipeptidase activity
TH3_RS02625	COG2423	ornithine cyclodeaminase activity
TH3_RS02630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TH3_RS02640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_RS02645	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TH3_RS02650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TH3_RS02655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_RS02660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TH3_RS02665	COG1012	belongs to the aldehyde dehydrogenase family
TH3_RS02680	COG1234	tRNA 3'-trailer cleavage
TH3_RS02700	COG1733	regulation of RNA biosynthetic process
TH3_RS02730	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
TH3_RS02760	COG3706	GGDEF domain
TH3_RS02765	COG0321	lipoyl(octanoyl) transferase activity
TH3_RS02775	COG0280	phosphate acetyltransferase
TH3_RS02775	COG0281	malic enzyme
TH3_RS02780	COG2239	Acts as a magnesium transporter
TH3_RS02810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TH3_RS02855	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS02885	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TH3_RS02895	COG2274	protein secretion by the type I secretion system
TH3_RS02900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_RS02910	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TH3_RS02920	COG0706	membrane insertase activity
TH3_RS02925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TH3_RS02930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TH3_RS02935	COG3706	GGDEF domain
TH3_RS02940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TH3_RS02945	COG0552	protein localization to endoplasmic reticulum
TH3_RS02955	COG0783	Belongs to the Dps family
TH3_RS02980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TH3_RS03015	COG0742	ribosomal rna small subunit methyltransferase
TH3_RS03020	COG1187	pseudouridine synthase activity
TH3_RS03025	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TH3_RS03030	COG0590	tRNA wobble adenosine to inosine editing
TH3_RS03035	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
TH3_RS03050	COG4221	oxidoreductase activity
TH3_RS03055	COG2207	Transcriptional regulator
TH3_RS03065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TH3_RS03070	COG1120	ATPase activity
TH3_RS03075	COG0151	Belongs to the GarS family
TH3_RS03080	COG1570	exodeoxyribonuclease VII activity
TH3_RS03090	COG0405	Gamma-glutamyltransferase
TH3_RS03105	COG1560	Kdo2-lipid A biosynthetic process
TH3_RS03110	COG1663	tetraacyldisaccharide 4'-kinase activity
TH3_RS03115	COG1519	Transferase
TH3_RS03125	COG1132	(ABC) transporter
TH3_RS03135	COG0438	transferase activity, transferring glycosyl groups
TH3_RS03145	COG1597	lipid kinase activity
TH3_RS03150	COG0312	modulator of DNA gyrase
TH3_RS03170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TH3_RS03195	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TH3_RS03225	COG3639	organic phosphonate transmembrane transporter activity
TH3_RS03240	COG1349	DNA-binding transcription factor activity
TH3_RS03270	COG1280	lysine exporter protein (LysE YggA)
TH3_RS03280	COG0604	alcohol dehydrogenase
TH3_RS03290	COG4608	Belongs to the ABC transporter superfamily
TH3_RS03295	COG0444	Belongs to the ABC transporter superfamily
TH3_RS03300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_RS03305	COG0601	transmembrane transport
TH3_RS03310	COG0747	negative chemotaxis
TH3_RS03340	COG0312	modulator of DNA gyrase
TH3_RS03355	COG1612	heme a metabolic process
TH3_RS03365	COG0175	sulfate reduction
TH3_RS03410	COG4953	penicillin-binding protein 1C
TH3_RS03415	COG1522	sequence-specific DNA binding
TH3_RS03420	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TH3_RS03440	COG3265	gluconokinase activity
TH3_RS03445	COG1609	Transcriptional regulator
TH3_RS03450	COG1739	Uncharacterized protein family UPF0029
TH3_RS03470	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TH3_RS03485	COG0393	Putative heavy-metal-binding
TH3_RS03490	COG0393	Putative heavy-metal-binding
TH3_RS03500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TH3_RS03515	COG0789	Transcriptional regulator
TH3_RS03545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TH3_RS03555	COG0010	Belongs to the arginase family
TH3_RS03565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_RS03585	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TH3_RS03595	COG0668	transmembrane transport
TH3_RS03600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TH3_RS03605	COG2962	Rard protein
TH3_RS03625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TH3_RS03650	COG2198	Histidine kinase
TH3_RS03650	COG0784	Response regulator, receiver
TH3_RS03650	COG0643	Histidine kinase
TH3_RS03675	COG0745	RESPONSE REGULATOR receiver
TH3_RS03695	COG0861	Integral membrane protein TerC family
TH3_RS03700	COG4134	Bacterial extracellular solute-binding protein
TH3_RS03705	COG4135	transport system, permease component
TH3_RS03710	COG4136	ATPase activity
TH3_RS03715	COG3128	pkhd-type hydroxylase
TH3_RS03725	COG0251	oxidation-reduction process
TH3_RS03750	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TH3_RS03755	COG2204	response regulator
TH3_RS03760	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TH3_RS03765	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TH3_RS03775	COG1766	The M ring may be actively involved in energy transduction
TH3_RS03780	COG1749	Flagellar hook protein flgE
TH3_RS03800	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TH3_RS03810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TH3_RS03815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TH3_RS03830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TH3_RS03855	COG3951	Flagellar rod assembly protein muramidase FlgJ
TH3_RS03860	COG1706	bacterial-type flagellum-dependent cell motility
TH3_RS03875	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TH3_RS03885	COG4786	Flagellar basal body rod
TH3_RS03890	COG4786	Flagellar basal body rod
TH3_RS03915	COG0745	RESPONSE REGULATOR receiver
TH3_RS03950	COG1338	Plays a role in the flagellum-specific transport system
TH3_RS03965	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TH3_RS03970	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TH3_RS03975	COG1815	bacterial-type flagellum-dependent cell motility
TH3_RS03980	COG1558	bacterial-type flagellum-dependent cell motility
TH3_RS03985	COG1677	Flagellar hook-basal body complex protein FliE
TH3_RS03990	COG1987	bacterial-type flagellum assembly
TH3_RS03995	COG1684	flagellar biosynthetic protein fliR
TH3_RS04000	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TH3_RS04125	COG0542	response to heat
TH3_RS04145	COG4187	Peptidase family M20/M25/M40
TH3_RS04150	COG0584	glycerophosphoryl diester phosphodiesterase
TH3_RS04155	COG0655	NAD(P)H dehydrogenase (quinone) activity
TH3_RS04185	COG1595	DNA-templated transcription, initiation
TH3_RS04195	COG0538	isocitrate dehydrogenase activity
TH3_RS04230	COG0395	ABC-type sugar transport system, permease component
TH3_RS04240	COG1653	transport
TH3_RS04245	COG3842	ATPase activity
TH3_RS04250	COG1349	DNA-binding transcription factor activity
TH3_RS04255	COG0492	ferredoxin-NADP+ reductase activity
TH3_RS04275	COG1611	Belongs to the LOG family
TH3_RS04290	COG0688	phosphatidylethanolamine metabolic process
TH3_RS04350	COG0602	queuosine metabolic process
TH3_RS04355	COG0720	synthase
TH3_RS04360	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TH3_RS04365	COG2226	methyltransferase
TH3_RS04380	COG2032	superoxide dismutase activity
TH3_RS04395	COG0495	leucyl-tRNA aminoacylation
TH3_RS04415	COG0438	transferase activity, transferring glycosyl groups
TH3_RS04485	COG1643	Atp-dependent helicase
TH3_RS04525	COG2084	Dehydrogenase
TH3_RS04565	COG3247	response to pH
TH3_RS04570	COG1819	glycosyl
TH3_RS04575	COG1199	ATP-dependent helicase activity
TH3_RS04600	COG1238	metal cluster binding
TH3_RS04610	COG1764	response to oxidative stress
TH3_RS04620	COG1846	Transcriptional regulator
TH3_RS04650	COG4191	Histidine kinase
TH3_RS04660	COG0506	proline dehydrogenase activity
TH3_RS04670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TH3_RS04675	COG1609	Transcriptional regulator
TH3_RS04680	COG1840	ABC-type Fe3 transport system, periplasmic component
TH3_RS04690	COG3842	ATPase activity
TH3_RS04695	COG0483	inositol monophosphate 1-phosphatase activity
TH3_RS04710	COG3422	double-strand break repair
TH3_RS04745	COG2963	transposase activity
TH3_RS04960	COG0167	dihydroorotate dehydrogenase activity
TH3_RS04985	COG0697	spore germination
TH3_RS04990	COG0747	negative chemotaxis
TH3_RS04995	COG0601	transmembrane transport
TH3_RS05000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_RS05005	COG4172	Belongs to the ABC transporter superfamily
TH3_RS05010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TH3_RS05015	COG2162	N-hydroxyarylamine O-acetyltransferase activity
TH3_RS05050	COG1595	DNA-templated transcription, initiation
TH3_RS05060	COG4774	siderophore transport
TH3_RS05070	COG0500	methyltransferase
TH3_RS05080	COG4120	Belongs to the binding-protein-dependent transport system permease family
TH3_RS05105	COG1309	transcriptional regulator
TH3_RS05110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_RS05115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TH3_RS05135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TH3_RS05155	COG2391	methyltransferase activity
TH3_RS05160	COG0513	Belongs to the DEAD box helicase family
TH3_RS05165	COG1278	Cold shock
TH3_RS05170	COG2186	Transcriptional regulator
TH3_RS05180	COG0765	amino acid transport
TH3_RS05185	COG0765	amino acid transport
TH3_RS05200	COG1671	Belongs to the UPF0178 family
TH3_RS05220	COG2130	NADP-dependent
TH3_RS05235	COG0523	cobalamin synthesis protein
TH3_RS05240	COG0625	glutathione transferase activity
TH3_RS05245	COG0625	glutathione transferase activity
TH3_RS05250	COG0477	Major facilitator Superfamily
TH3_RS05255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TH3_RS05260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TH3_RS05265	COG1845	cytochrome c oxidase, subunit III
TH3_RS05270	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TH3_RS05275	COG3346	SURF1 family
TH3_RS05285	COG2226	methyltransferase
TH3_RS05290	COG1309	transcriptional regulator
TH3_RS05295	COG1970	mechanosensitive ion channel activity
TH3_RS05305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TH3_RS05320	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TH3_RS05320	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TH3_RS05335	COG3180	Ammonia monooxygenase
TH3_RS05340	COG1335	isochorismatase
TH3_RS05360	COG2378	regulation of single-species biofilm formation
TH3_RS05370	COG3300	MHYT domain
TH3_RS05370	COG5001	Diguanylate cyclase
TH3_RS05385	COG1366	Belongs to the anti-sigma-factor antagonist family
TH3_RS05390	COG2204	response regulator
TH3_RS05420	COG0584	glycerophosphoryl diester phosphodiesterase
TH3_RS05425	COG1879	ABC-type sugar transport system periplasmic component
TH3_RS05435	COG0772	Belongs to the SEDS family
TH3_RS05440	COG0768	penicillin binding
TH3_RS05465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TH3_RS05470	COG1280	lysine exporter protein (LysE YggA)
TH3_RS05485	COG3706	GGDEF domain
TH3_RS05490	COG1278	Cold shock
TH3_RS05495	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TH3_RS05520	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TH3_RS05525	COG0840	transmembrane signaling receptor activity
TH3_RS05540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TH3_RS05540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TH3_RS05550	COG0519	Catalyzes the synthesis of GMP from XMP
TH3_RS05560	COG2824	Alkylphosphonate utilization operon protein PhnA
TH3_RS05570	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS05575	COG3655	Transcriptional regulator
TH3_RS05595	COG0640	Transcriptional regulator
TH3_RS05625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TH3_RS05630	COG0765	amino acid transport
TH3_RS05635	COG0765	amino acid transport
TH3_RS05690	COG1653	transport
TH3_RS05700	COG0395	ABC-type sugar transport system, permease component
TH3_RS05715	COG1012	belongs to the aldehyde dehydrogenase family
TH3_RS05720	COG0596	Alpha beta hydrolase
TH3_RS05725	COG0494	nUDIX hydrolase
TH3_RS05750	COG1653	transport
TH3_RS05765	COG0366	Alpha amylase catalytic
TH3_RS05770	COG3842	ATPase activity
TH3_RS05775	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TH3_RS05780	COG0363	glucosamine-6-phosphate deaminase activity
TH3_RS05785	COG0129	dihydroxy-acid dehydratase activity
TH3_RS05790	COG0837	glucose binding
TH3_RS05795	COG0800	Aldolase
TH3_RS05820	COG1595	DNA-templated transcription, initiation
TH3_RS05870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_RS05880	COG2719	SpoVR family
TH3_RS05885	COG2718	Belongs to the UPF0229 family
TH3_RS05890	COG2766	serine protein kinase
TH3_RS05895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TH3_RS05930	COG0251	oxidation-reduction process
TH3_RS05935	COG0251	oxidation-reduction process
TH3_RS05940	COG1309	transcriptional regulator
TH3_RS05960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TH3_RS05975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TH3_RS05985	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TH3_RS05995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TH3_RS06005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TH3_RS06010	COG0222	ribosome binding
TH3_RS06015	COG0085	RNA polymerase activity
TH3_RS06020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TH3_RS06035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TH3_RS06040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TH3_RS06050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TH3_RS06055	COG0088	Forms part of the polypeptide exit tunnel
TH3_RS06060	COG0089	rRNA binding
TH3_RS06070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TH3_RS06080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TH3_RS06085	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TH3_RS06090	COG0255	Belongs to the universal ribosomal protein uL29 family
TH3_RS06100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TH3_RS06105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TH3_RS06110	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TH3_RS06120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TH3_RS06125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TH3_RS06130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TH3_RS06140	COG1841	ribosomal large subunit assembly
TH3_RS06150	COG0201	protein transport
TH3_RS06155	COG0563	adenylate kinase activity
TH3_RS06160	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TH3_RS06165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TH3_RS06175	COG0203	ribosomal protein L17
TH3_RS06180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TH3_RS06195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TH3_RS06200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TH3_RS06210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TH3_RS06215	COG0564	pseudouridine synthase activity
TH3_RS06225	COG0546	phosphoglycolate phosphatase activity
TH3_RS06240	COG0412	Dienelactone hydrolase
TH3_RS06245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_RS06270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TH3_RS06275	COG4770	biotin carboxylase activity
TH3_RS06300	COG1254	Belongs to the acylphosphatase family
TH3_RS06315	COG0277	FAD linked oxidase domain protein
TH3_RS06320	COG0009	L-threonylcarbamoyladenylate synthase
TH3_RS06355	COG1355	regulation of microtubule-based process
TH3_RS06365	COG0456	acetyltransferase
TH3_RS06375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TH3_RS06405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TH3_RS06410	COG2011	ABC-type metal ion transport system permease component
TH3_RS06435	COG0477	Major facilitator Superfamily
TH3_RS06465	COG0798	PFAM Bile acid sodium symporter
TH3_RS06475	COG0431	NADPH-dependent FMN reductase
TH3_RS06495	COG0488	(ABC) transporter
TH3_RS06500	COG0105	UTP biosynthetic process
TH3_RS06515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TH3_RS06520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TH3_RS06530	COG0628	permease
TH3_RS06535	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TH3_RS06540	COG0189	ligase activity
TH3_RS06540	COG4067	protein conserved in archaea
TH3_RS06545	COG0189	ligase activity
TH3_RS06555	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TH3_RS06565	COG0702	epimerase
TH3_RS06570	COG0583	DNA-binding transcription factor activity
TH3_RS06580	COG0248	Ppx GppA phosphatase
TH3_RS06585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TH3_RS06610	COG0640	Transcriptional regulator
TH3_RS06615	COG0123	including yeast histone deacetylase and acetoin utilization protein
TH3_RS06635	COG0142	geranyltranstransferase activity
TH3_RS06645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TH3_RS06670	COG0318	PFAM AMP-dependent synthetase and ligase
TH3_RS06695	COG1802	Transcriptional regulator
TH3_RS06700	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TH3_RS06710	COG0583	DNA-binding transcription factor activity
TH3_RS06740	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TH3_RS06745	COG1295	ribonuclease BN
TH3_RS06755	COG0300	oxidoreductase activity
TH3_RS06760	COG0318	PFAM AMP-dependent synthetase and ligase
TH3_RS06770	COG3264	Mechanosensitive ion channel
TH3_RS06770	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
TH3_RS06790	COG0484	heat shock protein binding
TH3_RS06795	COG4520	surface antigen
TH3_RS06805	COG0640	Transcriptional regulator
TH3_RS06820	COG2135	peptidase activity
TH3_RS06825	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS06830	COG3153	acetyltransferase
TH3_RS06840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TH3_RS06850	COG0156	8-amino-7-oxononanoate synthase activity
TH3_RS06855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TH3_RS06890	COG2249	NAD(P)H dehydrogenase (quinone) activity
TH3_RS06895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TH3_RS06905	COG0659	secondary active sulfate transmembrane transporter activity
TH3_RS06910	COG1024	Enoyl-CoA hydratase
TH3_RS06910	COG1250	3-hydroxyacyl-CoA dehydrogenase
TH3_RS06920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_RS06925	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TH3_RS06940	COG4191	Histidine kinase
TH3_RS06950	COG0583	DNA-binding transcription factor activity
TH3_RS06955	COG2814	Major facilitator Superfamily
TH3_RS06965	COG0656	L-ascorbic acid biosynthetic process
TH3_RS06985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TH3_RS06995	COG1252	NADH dehydrogenase
TH3_RS07000	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TH3_RS07005	COG0583	DNA-binding transcription factor activity
TH3_RS07010	COG3622	Belongs to the hyi family
TH3_RS07025	COG2186	Transcriptional regulator
TH3_RS07035	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TH3_RS07085	COG3135	benzoate transporter
TH3_RS07115	COG0483	inositol monophosphate 1-phosphatase activity
TH3_RS07120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TH3_RS07125	COG0352	thiamine-phosphate diphosphorylase activity
TH3_RS07150	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TH3_RS07155	COG1692	metallophosphoesterase
TH3_RS07170	COG0217	transcriptional regulatory protein
TH3_RS07180	COG0632	four-way junction helicase activity
TH3_RS07185	COG2255	four-way junction helicase activity
TH3_RS07190	COG0824	Thioesterase
TH3_RS07200	COG0848	biopolymer transport protein
TH3_RS07215	COG2885	chlorophyll binding
TH3_RS07235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TH3_RS07240	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TH3_RS07260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TH3_RS07265	COG0351	phosphomethylpyrimidine kinase
TH3_RS07265	COG0352	thiamine-phosphate diphosphorylase activity
TH3_RS07280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TH3_RS07290	COG0129	dihydroxy-acid dehydratase activity
TH3_RS07300	COG1473	amidohydrolase
TH3_RS07305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_RS07315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_RS07320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TH3_RS07325	COG0583	DNA-binding transcription factor activity
TH3_RS07330	COG0686	Belongs to the AlaDH PNT family
TH3_RS07335	COG1522	sequence-specific DNA binding
TH3_RS07360	COG1177	transmembrane transport
TH3_RS07365	COG1176	ABC-type spermidine putrescine transport system, permease component I
TH3_RS07370	COG3842	ATPase activity
TH3_RS07380	COG0174	glutamine synthetase
TH3_RS07390	COG4948	Mandelate Racemase Muconate Lactonizing
TH3_RS07420	COG4095	Psort location CytoplasmicMembrane, score
TH3_RS07425	COG0842	Transport permease protein
TH3_RS07430	COG0842	Transport permease protein
TH3_RS07430	COG1129	ABC transporter
TH3_RS07435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_RS07445	COG2202	Pas domain
TH3_RS07445	COG2200	EAL domain
TH3_RS07445	COG2199	diguanylate cyclase activity
TH3_RS07460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TH3_RS07465	COG0583	DNA-binding transcription factor activity
TH3_RS07470	COG5642	Protein of unknown function (DUF2384)
TH3_RS07475	COG5654	RES domain protein
TH3_RS07480	COG0247	lactate metabolic process
TH3_RS07480	COG0277	FAD linked oxidase domain protein
TH3_RS07485	COG1116	anion transmembrane transporter activity
TH3_RS07495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TH3_RS07605	COG1840	ABC-type Fe3 transport system, periplasmic component
TH3_RS07620	COG3842	ATPase activity
TH3_RS07625	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TH3_RS07630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TH3_RS07635	COG2076	Multidrug Resistance protein
TH3_RS07660	COG2194	sulfuric ester hydrolase activity
TH3_RS07665	COG1309	transcriptional regulator
TH3_RS07670	COG0432	Pfam Uncharacterised protein family UPF0047
TH3_RS07685	COG2132	Multicopper oxidase
TH3_RS07715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TH3_RS07740	COG4765	Protein conserved in bacteria
TH3_RS07745	COG2353	YceI-like domain
TH3_RS07750	COG3038	cytochrome b561
TH3_RS07755	COG2353	YceI-like domain
TH3_RS07775	COG0400	carboxylic ester hydrolase activity
TH3_RS07780	COG0534	Mate efflux family protein
TH3_RS07785	COG1522	sequence-specific DNA binding
TH3_RS07795	COG1959	2 iron, 2 sulfur cluster binding
TH3_RS07800	COG0513	Belongs to the DEAD box helicase family
TH3_RS07830	COG2066	Belongs to the glutaminase family
TH3_RS07835	COG0187	DNA topoisomerase II activity
TH3_RS07840	COG1607	acyl-coa hydrolase
TH3_RS07855	COG4221	oxidoreductase activity
TH3_RS07870	COG4608	Belongs to the ABC transporter superfamily
TH3_RS07875	COG0444	Belongs to the ABC transporter superfamily
TH3_RS07880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_RS07885	COG0601	transmembrane transport
TH3_RS07890	COG0747	negative chemotaxis
TH3_RS07925	COG0469	pyruvate kinase activity
TH3_RS07945	COG0693	protein deglycase activity
TH3_RS07950	COG0668	transmembrane transport
TH3_RS07965	COG1832	CoA-binding protein
TH3_RS08005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TH3_RS08010	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TH3_RS08040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TH3_RS08050	COG0697	spore germination
TH3_RS08060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TH3_RS08070	COG1858	cytochrome C peroxidase
TH3_RS08075	COG2084	Dehydrogenase
TH3_RS08080	COG3243	poly(R)-hydroxyalkanoic acid synthase
TH3_RS08085	COG2885	chlorophyll binding
TH3_RS08090	COG0436	Aminotransferase
TH3_RS08100	COG1494	fructose-1,6-bisphosphatase
TH3_RS08105	COG0443	Heat shock 70 kDa protein
TH3_RS08120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TH3_RS08120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TH3_RS08135	COG2223	nitrite transmembrane transporter activity
TH3_RS08155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TH3_RS08175	COG1234	tRNA 3'-trailer cleavage
TH3_RS08205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TH3_RS08230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TH3_RS08240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TH3_RS08245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_RS08250	COG1116	anion transmembrane transporter activity
TH3_RS08260	COG3210	domain, Protein
TH3_RS08310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TH3_RS08315	COG0372	Belongs to the citrate synthase family
TH3_RS08340	COG0123	including yeast histone deacetylase and acetoin utilization protein
TH3_RS08390	COG0523	cobalamin synthesis protein
TH3_RS08410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TH3_RS08420	COG0626	cystathionine gamma-synthase activity
TH3_RS08430	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TH3_RS08445	COG2897	thiosulfate sulfurtransferase activity
TH3_RS08450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TH3_RS08495	COG1620	l-lactate permease
TH3_RS08500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TH3_RS08510	COG0583	DNA-binding transcription factor activity
TH3_RS08515	COG2814	Major facilitator Superfamily
TH3_RS08525	COG0494	nUDIX hydrolase
TH3_RS08530	COG3706	GGDEF domain
TH3_RS08535	COG1247	-acetyltransferase
TH3_RS08540	COG2195	Cleaves the N-terminal amino acid of tripeptides
TH3_RS08545	COG0484	heat shock protein binding
TH3_RS08595	COG0730	response to heat
TH3_RS08600	COG0425	Belongs to the sulfur carrier protein TusA family
TH3_RS08605	COG2153	protein acetylation
TH3_RS08640	COG1067	ATP-dependent peptidase activity
TH3_RS08650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TH3_RS08665	COG0156	8-amino-7-oxononanoate synthase activity
TH3_RS08675	COG3273	potassium ion transport
TH3_RS08675	COG0471	metal ion transport
TH3_RS08710	COG0564	pseudouridine synthase activity
TH3_RS08730	COG1846	Transcriptional regulator
TH3_RS08800	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TH3_RS08810	COG4175	Glycine betaine
TH3_RS08810	COG3448	diguanylate cyclase activity
TH3_RS08815	COG4176	ABC-type proline glycine betaine transport system permease component
TH3_RS08820	COG2113	Glycine betaine
TH3_RS08825	COG4176	ABC-type proline glycine betaine transport system permease component
TH3_RS08830	COG4175	Glycine betaine
TH3_RS08850	COG1840	ABC-type Fe3 transport system, periplasmic component
TH3_RS08855	COG1840	ABC-type Fe3 transport system, periplasmic component
TH3_RS08865	COG0303	'Molybdopterin
TH3_RS08870	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TH3_RS08880	COG0438	transferase activity, transferring glycosyl groups
TH3_RS08915	COG0747	negative chemotaxis
TH3_RS08920	COG0601	transmembrane transport
TH3_RS08925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_RS08930	COG2814	Major facilitator Superfamily
TH3_RS08940	COG2814	Major facilitator Superfamily
TH3_RS08945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TH3_RS08945	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TH3_RS08950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TH3_RS08955	COG1393	Belongs to the ArsC family
TH3_RS08960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TH3_RS08965	COG0405	Gamma-glutamyltransferase
TH3_RS08985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TH3_RS08990	COG0793	Belongs to the peptidase S41A family
TH3_RS09005	COG0557	exoribonuclease II activity
TH3_RS09010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TH3_RS09015	COG0758	DNA mediated transformation
TH3_RS09020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TH3_RS09025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TH3_RS09050	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TH3_RS09060	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TH3_RS09070	COG0840	transmembrane signaling receptor activity
TH3_RS09080	COG2223	nitrite transmembrane transporter activity
TH3_RS09095	COG0583	DNA-binding transcription factor activity
TH3_RS09100	COG1435	thymidine kinase activity
TH3_RS09115	COG2995	paraquat-inducible protein a
TH3_RS09120	COG3008	intermembrane lipid transfer
TH3_RS09120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TH3_RS09135	COG4977	sequence-specific DNA binding
TH3_RS09140	COG2814	Major facilitator Superfamily
TH3_RS09185	COG0174	glutamine synthetase
TH3_RS09190	COG1012	belongs to the aldehyde dehydrogenase family
TH3_RS09195	COG1454	alcohol dehydrogenase
TH3_RS09200	COG0519	Catalyzes the synthesis of GMP from XMP
TH3_RS09200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TH3_RS09205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TH3_RS09210	COG0737	Belongs to the 5'-nucleotidase family
TH3_RS09225	COG1744	ABC transporter substrate-binding protein PnrA-like
TH3_RS09230	COG3845	ABC transporter
TH3_RS09240	COG1079	Belongs to the binding-protein-dependent transport system permease family
TH3_RS09250	COG0295	cytidine deaminase activity
TH3_RS09255	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TH3_RS09260	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TH3_RS09270	COG0471	metal ion transport
TH3_RS09280	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TH3_RS09290	COG1126	abc transporter atp-binding protein
TH3_RS09295	COG0765	amino acid transport
TH3_RS09300	COG4597	amino acid ABC transporter
TH3_RS09305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TH3_RS09310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TH3_RS09315	COG0521	Mo-molybdopterin cofactor biosynthetic process
TH3_RS09325	COG0840	transmembrane signaling receptor activity
TH3_RS09340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TH3_RS09370	COG2814	Major facilitator Superfamily
TH3_RS09395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TH3_RS09405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TH3_RS09415	COG1122	ATPase activity
TH3_RS09430	COG0310	cobalt ion transport
TH3_RS09460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TH3_RS09460	COG1042	CoA-binding domain protein
TH3_RS09460	COG0045	succinate-CoA ligase (ADP-forming) activity
TH3_RS09475	COG4989	oxidoreductase activity
TH3_RS09490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TH3_RS09495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TH3_RS09500	COG1538	Outer membrane efflux protein
TH3_RS09510	COG0525	valine-tRNA ligase activity
TH3_RS09520	COG0512	Glutamine amidotransferase of anthranilate synthase
TH3_RS09540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TH3_RS09550	COG0316	Belongs to the HesB IscA family
TH3_RS09565	COG1472	Belongs to the glycosyl hydrolase 3 family
TH3_RS09570	COG1994	Peptidase M50
TH3_RS09575	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TH3_RS09580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TH3_RS09585	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TH3_RS09590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TH3_RS09595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TH3_RS09600	COG0805	protein transport
TH3_RS09620	COG4942	peptidase
TH3_RS09630	COG1862	Preprotein translocase
TH3_RS09635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TH3_RS09650	COG3737	Protein of unknown function (DUF498/DUF598)
TH3_RS09655	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TH3_RS09660	COG0668	transmembrane transport
TH3_RS09685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TH3_RS09690	COG0191	fructose-bisphosphate aldolase activity
TH3_RS09700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TH3_RS09705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TH3_RS09710	COG2188	Transcriptional regulator
TH3_RS09715	COG2971	BadF BadG BcrA BcrD
TH3_RS09720	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TH3_RS09730	COG1175	transmembrane transport
TH3_RS09740	COG3842	ATPase activity
TH3_RS09750	COG3842	ATPase activity
TH3_RS09755	COG1176	ABC-type spermidine putrescine transport system, permease component I
TH3_RS09760	COG1177	transmembrane transport
TH3_RS09775	COG0395	ABC-type sugar transport system, permease component
TH3_RS09780	COG3842	ATPase activity
TH3_RS09785	COG1956	GAF domain-containing protein
TH3_RS09790	COG0629	single-stranded DNA binding
TH3_RS09830	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TH3_RS09835	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TH3_RS09840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TH3_RS09850	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TH3_RS09895	COG2951	lytic endotransglycosylase activity
TH3_RS09905	COG1686	Belongs to the peptidase S11 family
TH3_RS09910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TH3_RS09925	COG0084	hydrolase, TatD family'
TH3_RS09930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TH3_RS09930	COG0321	lipoyl(octanoyl) transferase activity
TH3_RS09935	COG1846	Transcriptional regulator
TH3_RS09945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TH3_RS09950	COG1917	Cupin 2, conserved barrel domain protein
TH3_RS09955	COG0527	aspartate kinase activity
TH3_RS09960	COG3956	TIGRFAM MazG family protein
TH3_RS09965	COG0483	inositol monophosphate 1-phosphatase activity
TH3_RS09970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TH3_RS09985	COG0569	domain protein
TH3_RS09990	COG2204	response regulator
TH3_RS10030	COG1324	tolerance protein
TH3_RS10055	COG0776	regulation of translation
TH3_RS10065	COG0416	fatty acid biosynthetic process
TH3_RS10085	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TH3_RS10090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TH3_RS10095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TH3_RS10100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TH3_RS10100	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TH3_RS10110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TH3_RS10110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TH3_RS10115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TH3_RS10125	COG0698	ribose 5-phosphate isomerase
TH3_RS10175	COG1024	Enoyl-CoA hydratase
TH3_RS10200	COG0113	porphobilinogen synthase activity
TH3_RS10215	COG0318	PFAM AMP-dependent synthetase and ligase
TH3_RS10225	COG1012	belongs to the aldehyde dehydrogenase family
TH3_RS10230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TH3_RS10235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TH3_RS10240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TH3_RS10245	COG1360	Flagellar Motor Protein
TH3_RS10255	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_RS10260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_RS10270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TH3_RS10275	COG1381	Involved in DNA repair and RecF pathway recombination
TH3_RS10290	COG0571	ribonuclease III activity
TH3_RS10295	COG0681	Belongs to the peptidase S26 family
TH3_RS10305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TH3_RS10335	COG1573	uracil-dna glycosylase
TH3_RS10340	COG0514	ATP-dependent DNA helicase (RecQ)
TH3_RS10345	COG0386	Belongs to the glutathione peroxidase family
TH3_RS10350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TH3_RS10355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TH3_RS10360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TH3_RS10365	COG1196	nuclear chromosome segregation
TH3_RS10365	COG0741	lytic transglycosylase activity
TH3_RS10365	COG0739	heme binding
TH3_RS10380	COG0739	heme binding
TH3_RS10385	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TH3_RS10390	COG1058	Belongs to the CinA family
TH3_RS10390	COG1546	Belongs to the CinA family
TH3_RS10395	COG2867	negative regulation of translational initiation
TH3_RS10400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TH3_RS10405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TH3_RS10410	COG0508	dehydrogenase complex catalyzes the overall conversion of
TH3_RS10415	COG0508	dehydrogenase complex catalyzes the overall conversion of
TH3_RS10415	COG0022	dehydrogenase e1 component
TH3_RS10420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TH3_RS10425	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TH3_RS10430	COG0148	phosphopyruvate hydratase activity
TH3_RS10450	COG0149	triose-phosphate isomerase activity
TH3_RS10455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TH3_RS10460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TH3_RS10475	COG0443	Heat shock 70 kDa protein
TH3_RS10480	COG2861	carbohydrate metabolic process
TH3_RS10500	COG0315	cyclic pyranopterin monophosphate synthase activity
TH3_RS10510	COG2333	competence protein COMEC
TH3_RS10510	COG0658	competence protein
TH3_RS10515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TH3_RS10520	COG0372	Belongs to the citrate synthase family
TH3_RS10530	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TH3_RS10535	COG3494	Protein of unknown function (DUF1009)
TH3_RS10550	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TH3_RS10565	COG0750	zinc metalloprotease
TH3_RS10570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TH3_RS10580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TH3_RS10590	COG0528	UMP kinase activity
TH3_RS10595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TH3_RS10625	COG0442	prolyl-tRNA aminoacylation
TH3_RS10640	COG0346	lactoylglutathione lyase activity
TH3_RS10675	COG0713	ATP synthesis coupled electron transport
TH3_RS10685	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TH3_RS10690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TH3_RS10695	COG1034	ATP synthesis coupled electron transport
TH3_RS10700	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TH3_RS10705	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TH3_RS10720	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TH3_RS10725	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TH3_RS10735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TH3_RS10755	COG0776	regulation of translation
TH3_RS10785	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TH3_RS10785	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TH3_RS10795	COG2205	protein histidine kinase activity
TH3_RS10795	COG2202	Pas domain
TH3_RS10810	COG2217	Heavy metal translocating P-type atpase
TH3_RS10815	COG2193	ferroxidase activity
TH3_RS10825	COG3046	protein related to deoxyribodipyrimidine photolyase
TH3_RS10840	COG1175	transmembrane transport
TH3_RS10845	COG0395	ABC-type sugar transport system, permease component
TH3_RS10850	COG3842	ATPase activity
TH3_RS10870	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
TH3_RS10875	COG0166	Belongs to the GPI family
TH3_RS10890	COG0010	Belongs to the arginase family
TH3_RS10895	COG1012	belongs to the aldehyde dehydrogenase family
TH3_RS10900	COG1396	sequence-specific DNA binding
TH3_RS10900	COG1917	Cupin 2, conserved barrel domain protein
TH3_RS10905	COG0174	glutamine synthetase
TH3_RS10915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TH3_RS10930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TH3_RS10940	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TH3_RS10945	COG1012	belongs to the aldehyde dehydrogenase family
TH3_RS10960	COG4176	ABC-type proline glycine betaine transport system permease component
TH3_RS10975	COG0583	DNA-binding transcription factor activity
TH3_RS10985	COG1177	transmembrane transport
TH3_RS10995	COG3842	ATPase activity
TH3_RS11000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TH3_RS11005	COG3246	L-lysine catabolic process to acetate
TH3_RS11020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TH3_RS11025	COG0251	oxidation-reduction process
TH3_RS11045	COG2423	ornithine cyclodeaminase activity
TH3_RS11050	COG0657	acetylesterase activity
TH3_RS11060	COG3616	Alanine racemase, N-terminal domain
TH3_RS11070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_RS11075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_RS11100	COG0729	surface antigen
TH3_RS11105	COG0189	ligase activity
TH3_RS11150	COG0183	Belongs to the thiolase family
TH3_RS11155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TH3_RS11160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TH3_RS11165	COG3485	protocatechuate 3,4-dioxygenase
TH3_RS11170	COG3485	protocatechuate 3,4-dioxygenase
TH3_RS11175	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TH3_RS11180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TH3_RS11185	COG0583	DNA-binding transcription factor activity
TH3_RS11215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_RS11250	COG2814	Major facilitator Superfamily
TH3_RS11260	COG2375	cellular response to nickel ion
TH3_RS11290	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TH3_RS11315	COG3769	mannosylglycerate metabolic process
TH3_RS11320	COG1215	transferase activity, transferring glycosyl groups
TH3_RS11340	COG0366	Alpha amylase catalytic
TH3_RS11350	COG0583	DNA-binding transcription factor activity
TH3_RS11370	COG1414	Transcriptional regulator
TH3_RS11380	COG1247	-acetyltransferase
TH3_RS11400	COG1741	Belongs to the pirin family
TH3_RS11405	COG2337	Toxic component of a toxin-antitoxin (TA) module
TH3_RS11445	COG2186	Transcriptional regulator
TH3_RS11455	COG1172	Belongs to the binding-protein-dependent transport system permease family
TH3_RS11460	COG1172	Belongs to the binding-protein-dependent transport system permease family
TH3_RS11465	COG1129	ABC transporter
TH3_RS11470	COG1879	ABC-type sugar transport system periplasmic component
TH3_RS11475	COG2017	converts alpha-aldose to the beta-anomer
TH3_RS11490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_RS11495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_RS11500	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_RS11505	COG1802	Transcriptional regulator
TH3_RS11570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TH3_RS11595	COG0308	aminopeptidase N
TH3_RS11610	COG0628	permease
TH3_RS11615	COG1917	Cupin 2, conserved barrel domain protein
TH3_RS11615	COG2207	Transcriptional regulator
TH3_RS11620	COG1280	lysine exporter protein (LysE YggA)
TH3_RS11635	COG2205	protein histidine kinase activity
TH3_RS11645	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_RS11650	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_RS11665	COG4977	sequence-specific DNA binding
TH3_RS11695	COG0848	biopolymer transport protein
TH3_RS11700	COG0848	biopolymer transport protein
TH3_RS11705	COG0811	peptide transport
TH3_RS11725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TH3_RS11730	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TH3_RS11735	COG0697	spore germination
TH3_RS11755	COG0418	dihydroorotase activity
TH3_RS11775	COG0436	Aminotransferase
TH3_RS11790	COG3706	GGDEF domain
TH3_RS11800	COG1765	OsmC-like protein
TH3_RS11825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TH3_RS11840	COG1802	Transcriptional regulator
TH3_RS11845	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_RS11855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_RS11860	COG5002	protein histidine kinase activity
TH3_RS11860	COG5001	Diguanylate cyclase
TH3_RS11875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TH3_RS11885	COG0583	DNA-binding transcription factor activity
TH3_RS11900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TH3_RS11940	COG0482	sulfurtransferase activity
TH3_RS11945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TH3_RS11950	COG2975	iron-sulfur cluster assembly
TH3_RS11955	COG0633	Ferredoxin
TH3_RS11970	COG0316	Belongs to the HesB IscA family
TH3_RS11975	COG0822	iron-sulfur transferase activity
TH3_RS11980	COG1104	cysteine desulfurase activity
TH3_RS11985	COG1104	cysteine desulfurase activity
TH3_RS11990	COG1959	2 iron, 2 sulfur cluster binding
TH3_RS11995	COG1045	serine acetyltransferase
TH3_RS12000	COG2945	thiolester hydrolase activity
TH3_RS12010	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TH3_RS12025	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TH3_RS12030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TH3_RS12040	COG2833	Protein of unknown function (DUF455)
TH3_RS12050	COG0625	glutathione transferase activity
TH3_RS12085	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TH3_RS12090	COG0860	N-Acetylmuramoyl-L-alanine amidase
TH3_RS12100	COG1530	ribonuclease E activity
TH3_RS12105	COG0436	Aminotransferase
TH3_RS12115	COG0501	Belongs to the peptidase M48B family
TH3_RS12140	COG0511	ligase activity, forming carbon-carbon bonds
TH3_RS12145	COG0439	Biotin carboxylase
TH3_RS12150	COG1280	lysine exporter protein (LysE YggA)
TH3_RS12155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TH3_RS12165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TH3_RS12195	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TH3_RS12210	COG1686	Belongs to the peptidase S11 family
TH3_RS12220	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TH3_RS12230	COG0484	heat shock protein binding
TH3_RS12250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TH3_RS12255	COG2342	PFAM TM1410 hypothetical-related protein
TH3_RS12290	COG1522	sequence-specific DNA binding
TH3_RS12300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TH3_RS12305	COG1024	Enoyl-CoA hydratase
TH3_RS12310	COG4770	biotin carboxylase activity
TH3_RS12355	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TH3_RS12370	COG0583	DNA-binding transcription factor activity
TH3_RS12385	COG2084	Dehydrogenase
TH3_RS12390	COG0793	Belongs to the peptidase S41A family
TH3_RS12395	COG1960	acyl-CoA dehydrogenase activity
TH3_RS12400	COG0795	lipopolysaccharide-transporting ATPase activity
TH3_RS12410	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TH3_RS12415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TH3_RS12425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TH3_RS12430	COG0194	GDP metabolic process
TH3_RS12435	COG1561	YicC-like family, N-terminal region
TH3_RS12445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TH3_RS12450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TH3_RS12465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TH3_RS12470	COG0360	Binds together with S18 to 16S ribosomal RNA
TH3_RS12475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TH3_RS12485	COG0359	binds to the 23S rRNA
TH3_RS12490	COG0305	Participates in initiation and elongation during chromosome replication
TH3_RS12495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TH3_RS12500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TH3_RS12505	COG1127	ABC transporter
TH3_RS12520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TH3_RS12525	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS12540	COG0667	Aldo Keto reductase
TH3_RS12550	COG1160	GTP binding
TH3_RS12580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TH3_RS12585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TH3_RS12585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TH3_RS12595	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TH3_RS12600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TH3_RS12610	COG1902	pentaerythritol trinitrate reductase activity
TH3_RS12620	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TH3_RS12625	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TH3_RS12635	COG1091	dTDP-4-dehydrorhamnose reductase activity
TH3_RS12645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TH3_RS12650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TH3_RS12655	COG0546	phosphoglycolate phosphatase activity
TH3_RS12665	COG0129	dihydroxy-acid dehydratase activity
TH3_RS12670	COG4214	carbohydrate transport
TH3_RS12680	COG4213	ABC transporter substrate-binding protein
TH3_RS12695	COG0237	dephospho-CoA kinase activity
TH3_RS12705	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TH3_RS12720	COG1234	tRNA 3'-trailer cleavage
TH3_RS12730	COG4149	molybdate abc transporter
TH3_RS12735	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TH3_RS12815	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TH3_RS12840	COG1283	sodium-dependent phosphate transmembrane transporter activity
TH3_RS12860	COG0367	asparagine synthase
TH3_RS12865	COG1522	sequence-specific DNA binding
TH3_RS12870	COG3284	Transcriptional regulator
TH3_RS12875	COG1012	belongs to the aldehyde dehydrogenase family
TH3_RS12885	COG2855	membrane
TH3_RS12890	COG0583	DNA-binding transcription factor activity
TH3_RS12900	COG1271	oxidase subunit
TH3_RS12905	COG1294	oxidase, subunit
TH3_RS12925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TH3_RS12940	COG1012	belongs to the aldehyde dehydrogenase family
TH3_RS12945	COG3724	N-succinylarginine dihydrolase activity
TH3_RS12950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TH3_RS12955	COG1522	sequence-specific DNA binding
TH3_RS12960	COG0175	sulfate reduction
TH3_RS12985	COG0587	DNA-directed DNA polymerase activity
TH3_RS12995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_RS13005	COG0747	negative chemotaxis
TH3_RS13020	COG1116	anion transmembrane transporter activity
TH3_RS13020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TH3_RS13030	COG2223	nitrite transmembrane transporter activity
TH3_RS13040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TH3_RS13045	COG2146	nitrite reductase [NAD(P)H] activity
TH3_RS13050	COG0243	molybdopterin cofactor binding
TH3_RS13055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TH3_RS13055	COG1648	precorrin-2 dehydrogenase activity
TH3_RS13060	COG0583	DNA-binding transcription factor activity
TH3_RS13085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TH3_RS13100	COG2827	Endonuclease containing a URI domain
TH3_RS13105	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS13120	COG0800	Aldolase
TH3_RS13125	COG3734	2-keto-3-deoxy-galactonokinase
TH3_RS13135	COG4638	Rieske (2fe-2S)
TH3_RS13140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TH3_RS13145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TH3_RS13155	COG2086	electron transfer activity
TH3_RS13165	COG0788	formyltetrahydrofolate deformylase activity
TH3_RS13180	COG1309	transcriptional regulator
TH3_RS13185	COG4774	siderophore transport
TH3_RS13215	COG4774	siderophore transport
TH3_RS13220	COG1120	ATPase activity
TH3_RS13225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TH3_RS13235	COG4114	ferric iron reductase
TH3_RS13250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TH3_RS13265	COG0626	cystathionine gamma-synthase activity
TH3_RS13355	COG2948	multi-organism process
TH3_RS13365	COG4962	Type ii secretion system protein e
TH3_RS13400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TH3_RS13430	COG1204	response to ionizing radiation
TH3_RS13495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TH3_RS13500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TH3_RS13505	COG0438	transferase activity, transferring glycosyl groups
TH3_RS13510	COG1063	alcohol dehydrogenase
TH3_RS13520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TH3_RS13550	COG3842	ATPase activity
TH3_RS13565	COG0395	ABC-type sugar transport system, permease component
TH3_RS13595	COG0330	HflC and HflK could
TH3_RS13620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_RS13625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_RS13640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TH3_RS13645	COG1309	transcriptional regulator
TH3_RS13665	COG0493	'glutamate synthase
TH3_RS13685	COG4208	sulfate ABC transporter
TH3_RS13700	COG0826	peptidase U32
TH3_RS13720	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TH3_RS13740	COG3386	PFAM SMP-30 Gluconolaconase
TH3_RS13745	COG1120	ATPase activity
TH3_RS13760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TH3_RS13785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TH3_RS13800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_RS13805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TH3_RS13825	COG2017	converts alpha-aldose to the beta-anomer
TH3_RS13830	COG2186	Transcriptional regulator
TH3_RS13835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TH3_RS13860	COG0129	dihydroxy-acid dehydratase activity
TH3_RS13865	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS13870	COG4213	ABC transporter substrate-binding protein
TH3_RS13875	COG4214	carbohydrate transport
TH3_RS13890	COG1940	carbohydrate kinase activity
TH3_RS13895	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TH3_RS13905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TH3_RS13930	COG1609	Transcriptional regulator
TH3_RS13935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TH3_RS13945	COG3383	formate dehydrogenase (NAD+) activity
TH3_RS13960	COG0583	DNA-binding transcription factor activity
TH3_RS13965	COG2223	nitrite transmembrane transporter activity
TH3_RS13970	COG4191	Histidine kinase
TH3_RS13975	COG2204	response regulator
TH3_RS13980	COG1629	transport
TH3_RS13980	COG4774	siderophore transport
TH3_RS13990	COG4178	(ABC) transporter
TH3_RS14015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TH3_RS14025	COG3597	protein domain associated with
TH3_RS14040	COG3597	protein domain associated with
TH3_RS14075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TH3_RS14115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TH3_RS14120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TH3_RS14130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TH3_RS14140	COG2986	histidine ammonia-lyase
TH3_RS14180	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS14185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TH3_RS14205	COG0411	ABC transporter
TH3_RS14225	COG3483	tryptophan 2,3-dioxygenase activity
TH3_RS14240	COG1960	acyl-CoA dehydrogenase activity
TH3_RS14275	COG0673	inositol 2-dehydrogenase activity
TH3_RS14280	COG3718	enzyme involved in inositol metabolism
TH3_RS14290	COG3962	Belongs to the TPP enzyme family
TH3_RS14295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TH3_RS14300	COG1129	ABC transporter
TH3_RS14330	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TH3_RS14335	COG1609	Transcriptional regulator
TH3_RS14340	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS14400	COG2948	multi-organism process
TH3_RS14425	COG3451	type IV secretory pathway VirB4
TH3_RS14440	COG4962	Type ii secretion system protein e
TH3_RS14485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_RS14490	COG0601	transmembrane transport
TH3_RS14505	COG4172	Belongs to the ABC transporter superfamily
TH3_RS14515	COG0741	lytic transglycosylase activity
TH3_RS14520	COG0681	Belongs to the peptidase S26 family
TH3_RS14570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TH3_RS14590	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS14600	COG0842	Transport permease protein
TH3_RS14605	COG0842	Transport permease protein
TH3_RS14605	COG1129	ABC transporter
TH3_RS14610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_RS14665	COG2963	transposase activity
TH3_RS14700	COG1196	nuclear chromosome segregation
TH3_RS14700	COG0741	lytic transglycosylase activity
TH3_RS14700	COG0739	heme binding
TH3_RS14705	COG0583	DNA-binding transcription factor activity
TH3_RS14710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TH3_RS14715	COG4597	amino acid ABC transporter
TH3_RS14720	COG0765	amino acid transport
TH3_RS14725	COG1126	abc transporter atp-binding protein
TH3_RS14740	COG1965	Belongs to the frataxin family
TH3_RS14745	COG0254	rRNA binding
TH3_RS14765	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS14765	COG0604	alcohol dehydrogenase
TH3_RS14765	COG3321	synthase
TH3_RS14785	COG1349	DNA-binding transcription factor activity
TH3_RS14790	COG0583	DNA-binding transcription factor activity
TH3_RS14855	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TH3_RS14860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TH3_RS14875	COG0242	peptide deformylase activity
TH3_RS14880	COG1566	PFAM secretion protein HlyD family protein
TH3_RS14890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TH3_RS14895	COG2056	Na+-H+ antiporter family
TH3_RS14925	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TH3_RS14955	COG0542	response to heat
TH3_RS14975	COG2890	protein-(glutamine-N5) methyltransferase activity
TH3_RS14980	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TH3_RS14985	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TH3_RS14990	COG0124	histidyl-tRNA synthetase
TH3_RS14995	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TH3_RS15005	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
TH3_RS15010	COG2070	2-Nitropropane dioxygenase
TH3_RS15020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TH3_RS15030	COG0500	methyltransferase
TH3_RS15050	COG1136	(ABC) transporter
TH3_RS15050	COG0577	efflux transmembrane transporter activity
TH3_RS15075	COG2186	Transcriptional regulator
TH3_RS15090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TH3_RS15095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TH3_RS15100	COG0583	DNA-binding transcription factor activity
TH3_RS15105	COG0625	glutathione transferase activity
TH3_RS15110	COG1017	nitric oxide dioxygenase activity
TH3_RS15110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TH3_RS15120	COG1489	DNA binding
TH3_RS15125	COG0024	Methionine aminopeptidase
TH3_RS15130	COG2003	Belongs to the UPF0758 family
TH3_RS15145	COG0583	DNA-binding transcription factor activity
TH3_RS15175	COG4166	transmembrane transport
TH3_RS15180	COG0601	transmembrane transport
TH3_RS15185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_RS15225	COG2169	Transcriptional regulator
TH3_RS15225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TH3_RS15230	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS15235	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TH3_RS15240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TH3_RS15245	COG0583	DNA-binding transcription factor activity
TH3_RS15250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TH3_RS15260	COG0583	DNA-binding transcription factor activity
TH3_RS15275	COG2197	response regulator
TH3_RS15290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TH3_RS15295	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TH3_RS15300	COG0047	phosphoribosylformylglycinamidine synthase activity
TH3_RS15305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TH3_RS15325	COG0489	protein tyrosine kinase activity
TH3_RS15330	COG0330	HflC and HflK could
TH3_RS15350	COG3830	Belongs to the UPF0237 family
TH3_RS15350	COG0560	Phosphoserine phosphatase
TH3_RS15370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TH3_RS15375	COG0028	Belongs to the TPP enzyme family
TH3_RS15380	COG0440	acetolactate synthase activity
TH3_RS15385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TH3_RS15390	COG2313	pseudouridylate synthase activity
TH3_RS15405	COG0415	Belongs to the DNA photolyase family
TH3_RS15435	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TH3_RS15440	COG1530	ribonuclease E activity
TH3_RS15460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TH3_RS15470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TH3_RS15515	COG2197	response regulator
TH3_RS15530	COG0604	alcohol dehydrogenase
TH3_RS15535	COG3339	Conserved Protein
TH3_RS15560	COG0354	folic acid binding
TH3_RS15565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TH3_RS15565	COG0574	Belongs to the PEP-utilizing enzyme family
TH3_RS15575	COG0752	glycyl-tRNA synthetase alpha subunit
TH3_RS15585	COG2890	protein-(glutamine-N5) methyltransferase activity
TH3_RS15595	COG0142	geranyltranstransferase activity
TH3_RS15610	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_RS15630	COG3474	cytochrome
TH3_RS15640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TH3_RS15660	COG2358	TRAP transporter, solute receptor (TAXI family
TH3_RS15665	COG3246	L-lysine catabolic process to acetate
TH3_RS15670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TH3_RS15685	COG5002	protein histidine kinase activity
TH3_RS15685	COG2205	protein histidine kinase activity
TH3_RS15685	COG0784	Response regulator, receiver
TH3_RS15690	COG0367	asparagine synthase
TH3_RS15700	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TH3_RS15705	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TH3_RS15710	COG4774	siderophore transport
TH3_RS15735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TH3_RS15740	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TH3_RS15745	COG0306	phosphate transporter
TH3_RS15825	COG0277	FAD linked oxidase domain protein
TH3_RS15850	COG0559	Belongs to the binding-protein-dependent transport system permease family
TH3_RS15865	COG3811	Belongs to the UPF0386 family
TH3_RS15890	COG0069	glutamate synthase activity
TH3_RS15920	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TH3_RS15925	COG4221	oxidoreductase activity
TH3_RS15940	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TH3_RS15945	COG0488	(ABC) transporter
TH3_RS15955	COG3023	N-Acetylmuramoyl-L-alanine amidase
TH3_RS15975	COG1335	isochorismatase
TH3_RS15980	COG4977	sequence-specific DNA binding
TH3_RS16005	COG2001	Belongs to the MraZ family
TH3_RS16010	COG0275	rRNA processing
TH3_RS16025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TH3_RS16040	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TH3_RS16055	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
TH3_RS16080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TH3_RS16090	COG1181	Belongs to the D-alanine--D-alanine ligase family
TH3_RS16095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TH3_RS16105	COG3842	ATPase activity
TH3_RS16115	COG1175	transmembrane transport
TH3_RS16120	COG1653	transport
TH3_RS16135	COG4608	Belongs to the ABC transporter superfamily
TH3_RS16140	COG0444	Belongs to the ABC transporter superfamily
TH3_RS16145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TH3_RS16150	COG0601	transmembrane transport
TH3_RS16155	COG0747	negative chemotaxis
TH3_RS16160	COG1414	Transcriptional regulator
TH3_RS16165	COG0849	cell division
TH3_RS16170	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TH3_RS16180	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TH3_RS16190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TH3_RS16210	COG0697	spore germination
TH3_RS16220	COG0667	Aldo Keto reductase
TH3_RS16225	COG0006	proline dipeptidase activity
TH3_RS16235	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS16240	COG0730	response to heat
TH3_RS16250	COG2264	protein methyltransferase activity
TH3_RS16255	COG0210	DNA helicase
TH3_RS16280	COG2814	Major facilitator Superfamily
TH3_RS16285	COG1410	methionine synthase
TH3_RS16285	COG0646	methionine synthase
TH3_RS16300	COG2226	methyltransferase
TH3_RS16305	COG2853	Lipoprotein
TH3_RS16315	COG0488	(ABC) transporter
TH3_RS16325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TH3_RS16345	COG0725	ABC transporter, periplasmic molybdate-binding protein
TH3_RS16350	COG4149	molybdate abc transporter
TH3_RS16355	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TH3_RS16365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TH3_RS16380	COG0446	pyridine nucleotide-disulphide oxidoreductase
TH3_RS16380	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TH3_RS16390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TH3_RS16395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TH3_RS16410	COG2010	Cytochrome c
TH3_RS16415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TH3_RS16415	COG1648	precorrin-2 dehydrogenase activity
TH3_RS16420	COG2010	Cytochrome c
TH3_RS16450	COG0535	radical SAM domain protein
TH3_RS16465	COG1845	cytochrome c oxidase, subunit III
TH3_RS16475	COG0714	Associated with various cellular activities
TH3_RS16500	COG0826	peptidase U32
TH3_RS16505	COG0826	peptidase U32
TH3_RS16535	COG4263	nitrous-oxide reductase activity
TH3_RS16545	COG0745	RESPONSE REGULATOR receiver
TH3_RS16555	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TH3_RS16560	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TH3_RS16565	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TH3_RS16575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TH3_RS16590	COG0505	Belongs to the CarA family
TH3_RS16595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TH3_RS16600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TH3_RS16610	COG1522	sequence-specific DNA binding
TH3_RS16620	COG0492	ferredoxin-NADP+ reductase activity
TH3_RS16625	COG0583	DNA-binding transcription factor activity
TH3_RS16635	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TH3_RS16640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TH3_RS16645	COG0783	Belongs to the Dps family
TH3_RS16655	COG0154	amidase activity
TH3_RS16680	COG4336	lyase activity
TH3_RS16685	COG0583	DNA-binding transcription factor activity
TH3_RS16690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TH3_RS16700	COG0556	nucleotide-excision repair
TH3_RS16705	COG0436	Aminotransferase
TH3_RS16715	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TH3_RS16720	COG0450	alkyl hydroperoxide reductase
TH3_RS16725	COG0583	DNA-binding transcription factor activity
TH3_RS16740	COG4459	periplasmic nitrate reductase
TH3_RS16760	COG3043	anaerobic respiration
TH3_RS16765	COG3005	denitrification pathway
TH3_RS16770	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TH3_RS16770	COG1618	nucleotide phosphatase activity, acting on free nucleotides
TH3_RS16775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TH3_RS16775	COG0519	Catalyzes the synthesis of GMP from XMP
TH3_RS16790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TH3_RS16795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TH3_RS16850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TH3_RS16880	COG0745	RESPONSE REGULATOR receiver
TH3_RS16885	COG1846	Transcriptional regulator
TH3_RS16890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TH3_RS16895	COG0625	glutathione transferase activity
TH3_RS16900	COG3119	arylsulfatase activity
TH3_RS16905	COG0583	DNA-binding transcription factor activity
TH3_RS16915	COG0408	coproporphyrinogen oxidase activity
TH3_RS16920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TH3_RS16945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TH3_RS16950	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TH3_RS16950	COG0662	Cupin 2, conserved barrel domain protein
TH3_RS16975	COG1072	(Pantothenic acid kinase))
TH3_RS17010	COG2132	Multicopper oxidase
TH3_RS17020	COG1522	sequence-specific DNA binding
TH3_RS17045	COG1396	sequence-specific DNA binding
TH3_RS17060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TH3_RS17065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TH3_RS17070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TH3_RS17080	COG1321	iron dependent repressor
TH3_RS17085	COG0803	Belongs to the bacterial solute-binding protein 9 family
TH3_RS17090	COG1121	(ABC) transporter
TH3_RS17095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TH3_RS17095	COG1321	iron dependent repressor
TH3_RS17100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TH3_RS17120	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TH3_RS17125	COG1360	Flagellar Motor Protein
TH3_RS17135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TH3_RS17140	COG0612	Peptidase, M16
TH3_RS17145	COG0612	Peptidase, M16
TH3_RS17155	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TH3_RS17165	COG0196	riboflavin kinase activity
TH3_RS17170	COG2030	dehydratase
TH3_RS17175	COG2226	methyltransferase
TH3_RS17225	COG0737	Belongs to the 5'-nucleotidase family
TH3_RS17235	COG2207	Transcriptional regulator
TH3_RS17250	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TH3_RS17255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TH3_RS17260	COG1960	acyl-CoA dehydrogenase activity
TH3_RS17265	COG0583	DNA-binding transcription factor activity
TH3_RS17280	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
TH3_RS17335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TH3_RS17335	COG2205	protein histidine kinase activity
TH3_RS17345	COG4251	negative regulation of phosphorylation
TH3_RS17355	COG2832	Protein of unknown function (DUF454)
TH3_RS17385	COG1320	monovalent cation:proton antiporter activity
TH3_RS17390	COG2212	antiporter activity
TH3_RS17395	COG1863	multisubunit Na H antiporter MnhE subunit
TH3_RS17400	COG0651	ATP synthesis coupled electron transport
TH3_RS17405	COG1006	Multisubunit Na H antiporter MnhC subunit
TH3_RS17410	COG2111	Na H antiporter
TH3_RS17410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TH3_RS17425	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TH3_RS17470	COG0733	neurotransmitter:sodium symporter activity
TH3_RS17485	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TH3_RS17490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TH3_RS17500	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TH3_RS17505	COG1138	Cytochrome C-type biogenesis protein
TH3_RS17510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TH3_RS17515	COG3088	subunit of a heme lyase
TH3_RS17520	COG4235	cytochrome complex assembly
TH3_RS17520	COG3088	subunit of a heme lyase
TH3_RS17525	COG1349	DNA-binding transcription factor activity
TH3_RS17530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TH3_RS17540	COG1129	ABC transporter
TH3_RS17545	COG1172	Belongs to the binding-protein-dependent transport system permease family
TH3_RS17550	COG1172	Belongs to the binding-protein-dependent transport system permease family
TH3_RS17570	COG0741	lytic transglycosylase activity
TH3_RS17570	COG0739	heme binding
TH3_RS17570	COG1196	nuclear chromosome segregation
TH3_RS17575	COG1573	uracil-dna glycosylase
TH3_RS17585	COG1012	belongs to the aldehyde dehydrogenase family
TH3_RS17595	COG0583	DNA-binding transcription factor activity
TH3_RS17610	COG1473	amidohydrolase
TH3_RS17640	COG3646	Phage regulatory protein
TH3_RS17655	COG0328	RNA-DNA hybrid ribonuclease activity
TH3_RS17680	COG3621	Patatin-like phospholipase
TH3_RS17705	COG3142	Participates in the control of copper homeostasis
TH3_RS17710	COG1940	carbohydrate kinase activity
TH3_RS17715	COG0612	Peptidase, M16
TH3_RS17725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TH3_RS17750	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
TH3_RS17755	COG0109	protoheme IX farnesyltransferase activity
TH3_RS17760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TH3_RS17765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TH3_RS17775	COG1678	Uncharacterized ACR, COG1678
TH3_RS17780	COG4232	protein-disulfide reductase activity
TH3_RS17790	COG0678	peroxiredoxin activity
TH3_RS17790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TH3_RS17805	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TH3_RS17810	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TH3_RS17815	COG0509	glycine decarboxylation via glycine cleavage system
TH3_RS17820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TH3_RS17835	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TH3_RS17855	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TH3_RS17855	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TH3_RS17860	COG0604	alcohol dehydrogenase
TH3_RS17880	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TH3_RS17885	COG0625	glutathione transferase activity
TH3_RS17890	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
TH3_RS17895	COG1116	anion transmembrane transporter activity
TH3_RS17900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TH3_RS17905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TH3_RS17910	COG3604	Transcriptional regulator
TH3_RS17920	COG2096	Adenosyltransferase
TH3_RS17935	COG1250	3-hydroxyacyl-CoA dehydrogenase
TH3_RS17940	COG1070	Carbohydrate kinase
TH3_RS17945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TH3_RS17950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TH3_RS17960	COG0019	diaminopimelate decarboxylase activity
TH3_RS17970	COG2207	Transcriptional regulator
TH3_RS17990	COG2884	Cell division ATP-binding protein ftsE
TH3_RS18020	COG0697	spore germination
TH3_RS18025	COG0287	Prephenate dehydrogenase
TH3_RS18040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TH3_RS18045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TH3_RS18045	COG2813	Specifically methylates the guanine in position
TH3_RS18060	COG0314	molybdopterin synthase activity
TH3_RS18065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TH3_RS18070	COG2233	PERMEase
TH3_RS18080	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TH3_RS18085	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS18100	COG0745	RESPONSE REGULATOR receiver
TH3_RS18115	COG0581	inorganic phosphate transmembrane transporter activity
TH3_RS18120	COG0573	inorganic phosphate transmembrane transporter activity
TH3_RS18125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TH3_RS18140	COG0247	lactate metabolic process
TH3_RS18145	COG0277	FAD linked oxidase domain protein
TH3_RS18150	COG0277	FAD linked oxidase domain protein
TH3_RS18155	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TH3_RS18170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TH3_RS18180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TH3_RS18195	COG0747	negative chemotaxis
TH3_RS18225	COG1968	undecaprenyl-diphosphatase activity
TH3_RS18255	COG0778	Nitroreductase
TH3_RS18270	COG1058	Belongs to the CinA family
TH3_RS18270	COG1546	Belongs to the CinA family
TH3_RS18300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TH3_RS18305	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TH3_RS18315	COG1639	'signal transduction protein
TH3_RS18330	COG1742	UPF0060 membrane protein
TH3_RS18340	COG1522	sequence-specific DNA binding
TH3_RS18345	COG3186	Phenylalanine-4-hydroxylase
TH3_RS18370	COG1703	isobutyryl-CoA mutase activity
TH3_RS18385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TH3_RS18415	COG2095	MarC family integral membrane protein
TH3_RS18420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TH3_RS18420	COG0617	tRNA 3'-terminal CCA addition
TH3_RS18420	COG3620	sequence-specific DNA binding
TH3_RS18450	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS18460	COG3550	peptidyl-serine autophosphorylation
TH3_RS18465	COG0583	DNA-binding transcription factor activity
TH3_RS18470	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TH3_RS18480	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TH3_RS18485	COG1122	ATPase activity
TH3_RS18490	COG1268	BioY protein
TH3_RS18495	COG0640	Transcriptional regulator
TH3_RS18505	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TH3_RS18510	COG0830	nickel cation binding
TH3_RS18515	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TH3_RS18520	COG0804	urea catabolic process
TH3_RS18525	COG0832	Belongs to the urease beta subunit family
TH3_RS18530	COG0831	urea catabolic process
TH3_RS18535	COG0829	nickel cation binding
TH3_RS18545	COG0411	ABC transporter
TH3_RS18580	COG0583	DNA-binding transcription factor activity
TH3_RS18595	COG0840	transmembrane signaling receptor activity
TH3_RS18620	COG3845	ABC transporter
TH3_RS18625	COG0590	tRNA wobble adenosine to inosine editing
TH3_RS18635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TH3_RS18655	COG3195	allantoin biosynthetic process
TH3_RS18655	COG3648	Uricase
TH3_RS18660	COG4266	Belongs to the allantoicase family
TH3_RS18670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TH3_RS18685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TH3_RS18705	COG2030	dehydratase
TH3_RS18710	COG2301	Belongs to the HpcH HpaI aldolase family
TH3_RS18765	COG1842	Phage shock protein A
TH3_RS18770	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TH3_RS18780	COG1960	acyl-CoA dehydrogenase activity
TH3_RS18785	COG0288	reversible hydration of carbon dioxide
TH3_RS18800	COG0183	Belongs to the thiolase family
TH3_RS18805	COG1960	acyl-CoA dehydrogenase activity
TH3_RS18820	COG0513	Belongs to the DEAD box helicase family
TH3_RS18835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TH3_RS18840	COG3474	cytochrome
TH3_RS18855	COG1280	lysine exporter protein (LysE YggA)
TH3_RS18870	COG3263	regulation of cellular component size
TH3_RS18875	COG1522	sequence-specific DNA binding
TH3_RS18900	COG2154	pterin-4-alpha-carbinolamine dehydratase
TH3_RS18905	COG1573	uracil-dna glycosylase
TH3_RS18915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TH3_RS18925	COG1280	lysine exporter protein (LysE YggA)
TH3_RS18935	COG4172	Belongs to the ABC transporter superfamily
TH3_RS18940	COG4239	(ABC) transporter, permease
TH3_RS18945	COG4174	ABC transporter (Permease)
TH3_RS18950	COG4166	transmembrane transport
TH3_RS18955	COG0583	DNA-binding transcription factor activity
TH3_RS18970	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS18970	COG3321	synthase
TH3_RS18970	COG0604	alcohol dehydrogenase
TH3_RS19000	COG0693	protein deglycase activity
TH3_RS19025	COG1522	sequence-specific DNA binding
TH3_RS19030	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TH3_RS19040	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TH3_RS19055	COG2986	histidine ammonia-lyase
TH3_RS19060	COG1228	amidohydrolase
TH3_RS19085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TH3_RS19090	COG1741	Belongs to the pirin family
TH3_RS19095	COG0667	Aldo Keto reductase
TH3_RS19120	COG4181	ATPase activity
TH3_RS19125	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TH3_RS19130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TH3_RS19140	COG0670	Belongs to the BI1 family
TH3_RS19150	COG0501	Belongs to the peptidase M48B family
TH3_RS19160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_RS19170	COG2902	Dehydrogenase
TH3_RS19175	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TH3_RS19205	COG3118	belongs to the thioredoxin family
TH3_RS19215	COG2835	tetraacyldisaccharide 4'-kinase activity
TH3_RS19225	COG3047	cAMP biosynthetic process
TH3_RS19230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TH3_RS19240	COG0004	ammonium transporteR
TH3_RS19275	COG1074	ATP-dependent DNA helicase activity
TH3_RS19285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TH3_RS19295	COG0802	atpase or kinase
TH3_RS19310	COG1028	Short-chain dehydrogenase reductase Sdr
TH3_RS19320	COG1733	regulation of RNA biosynthetic process
TH3_RS19325	COG4702	Belongs to the UPF0303 family
TH3_RS19330	COG0481	GTPase activity
TH3_RS19335	COG4251	negative regulation of phosphorylation
TH3_RS19345	COG0072	phenylalanine-tRNA ligase activity
TH3_RS19350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TH3_RS19355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TH3_RS19360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TH3_RS19370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TH3_RS19405	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TH3_RS19415	COG0181	hydroxymethylbilane synthase activity
TH3_RS19435	COG0138	bifunctional purine biosynthesis protein purh
TH3_RS19445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TH3_RS19450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TH3_RS19455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TH3_RS19465	COG2183	response to ionizing radiation
TH3_RS19480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TH3_RS19500	COG1012	belongs to the aldehyde dehydrogenase family
TH3_RS19520	COG0583	DNA-binding transcription factor activity
TH3_RS19530	COG2807	transmembrane transport
TH3_RS19560	COG2067	long-chain fatty acid transport protein
TH3_RS19565	COG0318	PFAM AMP-dependent synthetase and ligase
TH3_RS19570	COG0789	Transcriptional regulator
TH3_RS19575	COG0183	Belongs to the thiolase family
TH3_RS19580	COG1250	3-hydroxyacyl-CoA dehydrogenase
TH3_RS19580	COG1024	Enoyl-CoA hydratase
TH3_RS19585	COG1960	acyl-CoA dehydrogenase activity
TH3_RS19595	COG1024	Enoyl-CoA hydratase
TH3_RS19600	COG0300	oxidoreductase activity
TH3_RS19610	COG2943	transferase activity, transferring hexosyl groups
TH3_RS19620	COG2207	Transcriptional regulator
TH3_RS19650	COG0730	response to heat
TH3_RS19655	COG2186	Transcriptional regulator
TH3_RS19680	COG3842	ATPase activity
TH3_RS19715	COG0583	DNA-binding transcription factor activity
TH3_RS19720	COG1741	Belongs to the pirin family
TH3_RS19750	COG2200	EAL domain
TH3_RS19805	COG3181	Tripartite tricarboxylate transporter family receptor
TH3_RS19825	COG3180	Ammonia monooxygenase
TH3_RS19840	COG1596	polysaccharide export
TH3_RS19845	COG0028	Belongs to the TPP enzyme family
TH3_RS19870	COG1131	(ABC) transporter
TH3_RS19880	COG0133	tryptophan synthase activity
TH3_RS19890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TH3_RS19895	COG0285	dihydrofolate synthase activity
TH3_RS19905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TH3_RS19905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TH3_RS19910	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TH3_RS19930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TH3_RS19940	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TH3_RS19945	COG0792	nuclease activity
TH3_RS19970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TH3_RS19975	COG1217	gtp-binding protein TYPA
TH3_RS19980	COG2211	Major facilitator Superfamily
TH3_RS19985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TH3_RS19990	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TH3_RS19995	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TH3_RS20000	COG1137	ATPase activity
TH3_RS20015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TH3_RS20015	COG0517	IMP dehydrogenase activity
TH3_RS20040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TH3_RS20045	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TH3_RS20050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TH3_RS20055	COG1420	regulation of RNA biosynthetic process
TH3_RS20075	COG0697	spore germination
TH3_RS20095	COG0583	DNA-binding transcription factor activity
TH3_RS20110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TH3_RS20125	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TH3_RS20130	COG2992	FlgJ-related protein
TH3_RS20145	COG0280	phosphate acetyltransferase
TH3_RS20145	COG0281	malic enzyme
TH3_RS20155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TH3_RS20165	COG0728	peptidoglycan biosynthetic process
TH3_RS20170	COG0180	Tryptophanyl-tRNA synthetase
TH3_RS20185	COG0745	RESPONSE REGULATOR receiver
TH3_RS20255	COG0445	tRNA wobble uridine modification
TH3_RS20260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TH3_RS20275	COG1331	Highly conserved protein containing a thioredoxin domain
TH3_RS20290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TH3_RS20295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TH3_RS20325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TH3_RS20330	COG0237	dephospho-CoA kinase activity
TH3_RS20340	COG0424	maF-like protein
TH3_RS20345	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TH3_RS20360	COG1981	membrane
TH3_RS20365	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TH3_RS20370	COG3030	protein affecting phage T7 exclusion by the F plasmid
TH3_RS20375	COG4395	Tim44
TH3_RS20490	COG0583	DNA-binding transcription factor activity
TH3_RS20495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TH3_RS20525	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TH3_RS20535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TH3_RS20545	COG0131	Imidazoleglycerol-phosphate dehydratase
TH3_RS20550	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TH3_RS20560	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TH3_RS20565	COG5002	protein histidine kinase activity
TH3_RS20580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TH3_RS20585	COG0756	dUTP diphosphatase activity
TH3_RS20590	COG1959	2 iron, 2 sulfur cluster binding
TH3_RS20600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TH3_RS20610	COG1280	lysine exporter protein (LysE YggA)
TH3_RS20620	COG1285	pathogenesis
TH3_RS20625	COG1609	Transcriptional regulator
TH3_RS20630	COG2723	6-phospho-beta-galactosidase activity
TH3_RS20635	COG1653	transport
TH3_RS20640	COG1175	transmembrane transport
TH3_RS20650	COG3842	ATPase activity
TH3_RS20695	COG1702	phosphate starvation-inducible protein PhoH
TH3_RS20705	COG1253	flavin adenine dinucleotide binding
TH3_RS20710	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TH3_RS20715	COG1396	sequence-specific DNA binding
TH3_RS20720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TH3_RS20725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TH3_RS20730	COG1595	DNA-templated transcription, initiation
TH3_RS20740	COG1629	transport
TH3_RS20740	COG4206	TonB-dependent receptor
TH3_RS20750	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
TH3_RS20755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TH3_RS20775	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TH3_RS20790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TH3_RS20795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TH3_RS20800	COG1185	polyribonucleotide nucleotidyltransferase activity
TH3_RS20815	COG1592	Rubrerythrin
TH3_RS20825	COG1120	ATPase activity
TH3_RS20830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TH3_RS20840	COG2226	methyltransferase
TH3_RS20850	COG2186	Transcriptional regulator
TH3_RS20870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TH3_RS20875	COG1268	BioY protein
TH3_RS20890	COG1305	Transglutaminase-like
TH3_RS20900	COG2308	Evidence 4 Homologs of previously reported genes of
TH3_RS20905	COG2875	Belongs to the precorrin methyltransferase family
TH3_RS20930	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
TH3_RS20935	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TH3_RS20960	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TH3_RS20965	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TH3_RS20970	COG0588	phosphoglycerate mutase activity
TH3_RS21010	COG1492	cobalamin metabolic process
TH3_RS21055	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TH3_RS21070	COG1999	signal sequence binding
TH3_RS21075	COG1797	cobyrinic acid a,c-diamide synthase activity
TH3_RS21085	COG1234	tRNA 3'-trailer cleavage
TH3_RS21095	COG0071	Belongs to the small heat shock protein (HSP20) family
TH3_RS21105	COG0519	Catalyzes the synthesis of GMP from XMP
TH3_RS21125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TH3_RS21150	COG0539	negative regulation of cytoplasmic translation
TH3_RS21155	COG0616	signal peptide processing
TH3_RS21160	COG0776	regulation of translation
TH3_RS21170	COG0284	orotidine-5'-phosphate decarboxylase activity
TH3_RS21175	COG2814	Major facilitator Superfamily
TH3_RS21180	COG0730	response to heat
TH3_RS21185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TH3_RS21190	COG1024	Enoyl-CoA hydratase
TH3_RS21195	COG0268	Binds directly to 16S ribosomal RNA
TH3_RS21625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TH3_RS22205	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TH3_RS22215	COG2373	Large extracellular alpha-helical protein
TH3_RS22230	COG1256	bacterial-type flagellum assembly
TH3_RS22260	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
TH3_RS22290	COG0784	Response regulator, receiver
TH3_RS22290	COG5002	protein histidine kinase activity
TH3_RS22310	COG2814	Major facilitator Superfamily
TH3_RS22350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TH3_RS22355	COG2831	hemolysin activation secretion protein
TH3_RS22400	COG0443	Heat shock 70 kDa protein
TH3_RS22420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TH3_RS22430	COG2207	Transcriptional regulator
TH3_RS22470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TH3_RS22490	COG0840	transmembrane signaling receptor activity
TH3_RS22515	COG0840	transmembrane signaling receptor activity
TH3_RS22525	COG0352	thiamine-phosphate diphosphorylase activity