locus-tag	class	description
E2K93_RS00055	COG2897	thiosulfate sulfurtransferase activity
E2K93_RS00060	COG0322	excinuclease ABC activity
E2K93_RS00065	COG2197	response regulator
E2K93_RS00075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E2K93_RS00090	COG0488	(ABC) transporter
E2K93_RS00100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E2K93_RS00100	COG0116	Belongs to the methyltransferase superfamily
E2K93_RS00155	COG1254	Belongs to the acylphosphatase family
E2K93_RS00160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E2K93_RS00170	COG1643	Atp-dependent helicase
E2K93_RS00190	COG0745	RESPONSE REGULATOR receiver
E2K93_RS00200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E2K93_RS00205	COG1074	ATP-dependent DNA helicase activity
E2K93_RS00210	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E2K93_RS00235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2K93_RS00240	COG2249	NAD(P)H dehydrogenase (quinone) activity
E2K93_RS00250	COG2814	Major facilitator Superfamily
E2K93_RS00260	COG2925	Exonuclease
E2K93_RS00265	COG2084	Dehydrogenase
E2K93_RS00270	COG0386	Belongs to the glutathione peroxidase family
E2K93_RS00275	COG0527	aspartate kinase activity
E2K93_RS00280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E2K93_RS00290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E2K93_RS00305	COG1185	polyribonucleotide nucleotidyltransferase activity
E2K93_RS00310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E2K93_RS00345	COG2304	oxidoreductase activity
E2K93_RS00365	COG0714	Associated with various cellular activities
E2K93_RS00375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E2K93_RS00380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E2K93_RS00385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E2K93_RS00390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E2K93_RS00395	COG0195	Participates in both transcription termination and antitermination
E2K93_RS00400	COG0779	Required for maturation of 30S ribosomal subunits
E2K93_RS00425	COG0745	RESPONSE REGULATOR receiver
E2K93_RS00460	COG0513	Belongs to the DEAD box helicase family
E2K93_RS00475	COG4974	Belongs to the 'phage' integrase family
E2K93_RS00490	COG3311	Transcriptional regulator
E2K93_RS00500	COG0582	viral genome integration into host DNA
E2K93_RS00510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2K93_RS00515	COG0149	triose-phosphate isomerase activity
E2K93_RS00520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E2K93_RS00525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E2K93_RS00530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2K93_RS00535	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E2K93_RS00540	COG1534	Rna-binding protein
E2K93_RS00545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2K93_RS00570	COG2197	response regulator
E2K93_RS00575	COG4585	Histidine kinase
E2K93_RS00600	COG0454	-acetyltransferase
E2K93_RS00605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2K93_RS00610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E2K93_RS00615	COG0505	Belongs to the CarA family
E2K93_RS00620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E2K93_RS00625	COG0545	Peptidyl-prolyl cis-trans isomerase
E2K93_RS00645	COG3038	cytochrome b561
E2K93_RS00650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E2K93_RS00655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E2K93_RS00660	COG2226	methyltransferase
E2K93_RS00665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2K93_RS00670	COG1388	LysM domain
E2K93_RS00670	COG0741	lytic transglycosylase activity
E2K93_RS00675	COG1757	Na H antiporter
E2K93_RS00705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E2K93_RS00710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E2K93_RS00715	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E2K93_RS00725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E2K93_RS00735	COG3001	Fructosamine kinase
E2K93_RS00745	COG0307	riboflavin synthase, alpha
E2K93_RS00750	COG0534	Mate efflux family protein
E2K93_RS00770	COG0579	oxidoreductase
E2K93_RS00805	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E2K93_RS00810	COG0848	biopolymer transport protein
E2K93_RS00815	COG0811	peptide transport
E2K93_RS00820	COG0811	peptide transport
E2K93_RS00860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E2K93_RS00865	COG0857	belongs to the CobB CobQ family
E2K93_RS00865	COG0280	phosphate acetyltransferase
E2K93_RS00890	COG0028	Belongs to the TPP enzyme family
E2K93_RS00900	COG3012	SEC-C Motif Domain Protein
E2K93_RS00905	COG2205	protein histidine kinase activity
E2K93_RS00910	COG0745	RESPONSE REGULATOR receiver
E2K93_RS00915	COG0708	Exodeoxyribonuclease III
E2K93_RS00920	COG2226	methyltransferase
E2K93_RS00925	COG3092	negative regulation of chromosome organization
E2K93_RS00935	COG1393	Belongs to the ArsC family
E2K93_RS00945	COG1876	peptidase activity
E2K93_RS00955	COG0583	DNA-binding transcription factor activity
E2K93_RS00965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E2K93_RS00980	COG0006	proline dipeptidase activity
E2K93_RS00995	COG2350	Protein conserved in bacteria
E2K93_RS01005	COG0628	permease
E2K93_RS01010	COG1090	epimerase
E2K93_RS01015	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E2K93_RS01020	COG4181	ATPase activity
E2K93_RS01025	COG2755	lipolytic protein G-D-S-L family
E2K93_RS01030	COG5002	protein histidine kinase activity
E2K93_RS01030	COG2198	Histidine kinase
E2K93_RS01030	COG0784	Response regulator, receiver
E2K93_RS01045	COG0471	metal ion transport
E2K93_RS01050	COG1472	Belongs to the glycosyl hydrolase 3 family
E2K93_RS01055	COG1309	transcriptional regulator
E2K93_RS01075	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E2K93_RS01085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2K93_RS01090	COG0733	neurotransmitter:sodium symporter activity
E2K93_RS01100	COG1506	peptidase
E2K93_RS01100	COG0823	Involved in the tonB-independent uptake of proteins
E2K93_RS01120	COG1760	l-serine dehydratase
E2K93_RS01145	COG3148	PFAM DTW domain containing protein
E2K93_RS01150	COG2983	Belongs to the UPF0260 family
E2K93_RS01155	COG2951	lytic endotransglycosylase activity
E2K93_RS01160	COG3100	YcgL domain-containing protein
E2K93_RS01165	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E2K93_RS01170	COG0318	PFAM AMP-dependent synthetase and ligase
E2K93_RS01190	COG1214	PFAM Peptidase M22, glycoprotease
E2K93_RS01195	COG1199	ATP-dependent helicase activity
E2K93_RS01200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E2K93_RS01205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E2K93_RS01215	COG0131	Imidazoleglycerol-phosphate dehydratase
E2K93_RS01215	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E2K93_RS01220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E2K93_RS01225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E2K93_RS01235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E2K93_RS01235	COG0140	phosphoribosyl-ATP diphosphatase activity
E2K93_RS01240	COG2153	protein acetylation
E2K93_RS01260	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E2K93_RS01280	COG0326	Molecular chaperone. Has ATPase activity
E2K93_RS01285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E2K93_RS01300	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
E2K93_RS01305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E2K93_RS01315	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E2K93_RS01320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E2K93_RS01325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E2K93_RS01360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E2K93_RS01365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E2K93_RS01375	COG0589	response to stress
E2K93_RS01390	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E2K93_RS01460	COG1088	dTDP-glucose 4,6-dehydratase activity
E2K93_RS01500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E2K93_RS01520	COG0438	transferase activity, transferring glycosyl groups
E2K93_RS01585	COG1596	polysaccharide export
E2K93_RS01665	COG3590	peptidase
E2K93_RS01670	COG0529	Catalyzes the synthesis of activated sulfate
E2K93_RS01675	COG3273	potassium ion transport
E2K93_RS01675	COG0471	metal ion transport
E2K93_RS01680	COG2895	sulfate adenylyltransferase (ATP) activity
E2K93_RS01685	COG0175	sulfate reduction
E2K93_RS01690	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E2K93_RS01695	COG2835	tetraacyldisaccharide 4'-kinase activity
E2K93_RS01705	COG1132	(ABC) transporter
E2K93_RS01710	COG0658	competence protein
E2K93_RS01710	COG2333	competence protein COMEC
E2K93_RS01725	COG4591	ABC-type transport system involved in lipoprotein release permease component
E2K93_RS01735	COG4591	ABC-type transport system involved in lipoprotein release permease component
E2K93_RS01740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E2K93_RS01755	COG1335	isochorismatase
E2K93_RS01760	COG1187	pseudouridine synthase activity
E2K93_RS01785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E2K93_RS01790	COG3171	Protein conserved in bacteria
E2K93_RS01795	COG1194	a g-specific adenine glycosylase
E2K93_RS01800	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E2K93_RS01820	COG0348	domain, Protein
E2K93_RS01820	COG3901	Regulator of nitric oxide reductase transcription
E2K93_RS01870	COG1476	TRANSCRIPTIONal
E2K93_RS01925	COG1611	Belongs to the LOG family
E2K93_RS01930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E2K93_RS01940	COG0473	3-isopropylmalate dehydrogenase activity
E2K93_RS01945	COG1404	Belongs to the peptidase S8 family
E2K93_RS01950	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E2K93_RS01965	COG0583	DNA-binding transcription factor activity
E2K93_RS01990	COG1301	dicarboxylic acid transport
E2K93_RS01995	COG0500	methyltransferase
E2K93_RS02000	COG0616	signal peptide processing
E2K93_RS02010	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_RS02020	COG2890	protein-(glutamine-N5) methyltransferase activity
E2K93_RS02025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E2K93_RS02030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E2K93_RS02035	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E2K93_RS02045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E2K93_RS02050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E2K93_RS02055	COG0193	aminoacyl-tRNA hydrolase activity
E2K93_RS02065	COG1454	alcohol dehydrogenase
E2K93_RS02065	COG1012	belongs to the aldehyde dehydrogenase family
E2K93_RS02075	COG1278	Cold shock
E2K93_RS02080	COG1022	Amp-dependent synthetase and ligase
E2K93_RS02085	COG0564	pseudouridine synthase activity
E2K93_RS02120	COG5002	protein histidine kinase activity
E2K93_RS02125	COG0745	RESPONSE REGULATOR receiver
E2K93_RS02140	COG0604	alcohol dehydrogenase
E2K93_RS02170	COG1472	Belongs to the glycosyl hydrolase 3 family
E2K93_RS02180	COG3459	Glycosyltransferase 36 associated
E2K93_RS02185	COG2211	Major facilitator Superfamily
E2K93_RS02230	COG1472	Belongs to the glycosyl hydrolase 3 family
E2K93_RS02245	COG2211	Major facilitator Superfamily
E2K93_RS02250	COG1609	Transcriptional regulator
E2K93_RS02275	COG0519	Catalyzes the synthesis of GMP from XMP
E2K93_RS02275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E2K93_RS02285	COG0174	glutamine synthetase
E2K93_RS02320	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E2K93_RS02335	COG0488	(ABC) transporter
E2K93_RS02355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E2K93_RS02360	COG0513	Belongs to the DEAD box helicase family
E2K93_RS02370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2K93_RS02410	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E2K93_RS02420	COG0318	PFAM AMP-dependent synthetase and ligase
E2K93_RS02450	COG0804	urea catabolic process
E2K93_RS02455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K93_RS02470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2K93_RS02535	COG1136	(ABC) transporter
E2K93_RS02545	COG2207	Transcriptional regulator
E2K93_RS02580	COG2151	metal-sulfur cluster biosynthetic enzyme
E2K93_RS02590	COG2855	membrane
E2K93_RS02595	COG1960	acyl-CoA dehydrogenase activity
E2K93_RS02605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E2K93_RS02610	COG2890	protein-(glutamine-N5) methyltransferase activity
E2K93_RS02615	COG2840	Smr protein MutS2
E2K93_RS02620	COG2062	phosphohistidine phosphatase, SixA
E2K93_RS02625	COG1025	Belongs to the peptidase M16 family
E2K93_RS02640	COG1024	Enoyl-CoA hydratase
E2K93_RS02640	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2K93_RS02645	COG0183	Belongs to the thiolase family
E2K93_RS02650	COG0714	Associated with various cellular activities
E2K93_RS02670	COG2304	oxidoreductase activity
E2K93_RS02695	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E2K93_RS02700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2K93_RS02710	COG1215	transferase activity, transferring glycosyl groups
E2K93_RS02735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E2K93_RS02740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E2K93_RS02770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2K93_RS02775	COG3104	oligopeptide transport
E2K93_RS02780	COG1404	Belongs to the peptidase S8 family
E2K93_RS02790	COG1228	amidohydrolase
E2K93_RS02810	COG4771	TonB-dependent receptor
E2K93_RS02840	COG1404	Belongs to the peptidase S8 family
E2K93_RS02875	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E2K93_RS02880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E2K93_RS02885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2K93_RS02890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E2K93_RS02900	COG2853	Lipoprotein
E2K93_RS02925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E2K93_RS02930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2K93_RS02935	COG0126	phosphoglycerate kinase activity
E2K93_RS02970	COG2914	Belongs to the UPF0125 (RnfH) family
E2K93_RS02975	COG2867	negative regulation of translational initiation
E2K93_RS02980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E2K93_RS03000	COG5001	Diguanylate cyclase
E2K93_RS03000	COG1716	ATPase activity
E2K93_RS03015	COG0745	RESPONSE REGULATOR receiver
E2K93_RS03020	COG2205	protein histidine kinase activity
E2K93_RS03075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E2K93_RS03080	COG1047	Peptidyl-prolyl cis-trans
E2K93_RS03090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E2K93_RS03095	COG0196	riboflavin kinase activity
E2K93_RS03100	COG0728	peptidoglycan biosynthetic process
E2K93_RS03105	COG0268	Binds directly to 16S ribosomal RNA
E2K93_RS03120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E2K93_RS03125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E2K93_RS03130	COG0730	response to heat
E2K93_RS03140	COG1051	belongs to the nudix hydrolase family
E2K93_RS03145	COG3066	DNA modification
E2K93_RS03150	COG0676	glucose-6-phosphate 1-epimerase activity
E2K93_RS03200	COG4964	Belongs to the GSP D family
E2K93_RS03270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2K93_RS03275	COG0463	Glycosyl transferase, family 2
E2K93_RS03285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E2K93_RS03290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E2K93_RS03295	COG0497	DNA recombination
E2K93_RS03300	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2K93_RS03315	COG1595	DNA-templated transcription, initiation
E2K93_RS03320	COG0583	DNA-binding transcription factor activity
E2K93_RS03325	COG0306	phosphate transporter
E2K93_RS03330	COG1392	Phosphate transport regulator
E2K93_RS03335	COG0704	Plays a role in the regulation of phosphate uptake
E2K93_RS03340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E2K93_RS03345	COG0573	inorganic phosphate transmembrane transporter activity
E2K93_RS03380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2K93_RS03380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2K93_RS03385	COG0339	signal peptide processing
E2K93_RS03390	COG2204	response regulator
E2K93_RS03420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2K93_RS03420	COG0784	Response regulator, receiver
E2K93_RS03420	COG2198	Histidine kinase
E2K93_RS03420	COG2205	protein histidine kinase activity
E2K93_RS03425	COG0488	(ABC) transporter
E2K93_RS03430	COG3590	peptidase
E2K93_RS03440	COG2119	membrane
E2K93_RS03445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2K93_RS03450	COG0826	peptidase U32
E2K93_RS03455	COG2974	May be involved in recombination
E2K93_RS03460	COG1950	PFAM Membrane protein of
E2K93_RS03465	COG5002	protein histidine kinase activity
E2K93_RS03470	COG0745	RESPONSE REGULATOR receiver
E2K93_RS03500	COG0301	tRNA thio-modification
E2K93_RS03500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2K93_RS03505	COG1722	exodeoxyribonuclease VII activity
E2K93_RS03510	COG0142	geranyltranstransferase activity
E2K93_RS03515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E2K93_RS03540	COG0443	Heat shock 70 kDa protein
E2K93_RS03545	COG3437	response regulator, receiver
E2K93_RS03550	COG2205	protein histidine kinase activity
E2K93_RS03550	COG3437	response regulator, receiver
E2K93_RS03550	COG3850	Histidine kinase
E2K93_RS03550	COG4999	Histidine kinase
E2K93_RS03555	COG2814	Major facilitator Superfamily
E2K93_RS03565	COG1451	nucleotide metabolic process
E2K93_RS03575	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E2K93_RS03605	COG0583	DNA-binding transcription factor activity
E2K93_RS03615	COG2205	protein histidine kinase activity
E2K93_RS03620	COG0745	RESPONSE REGULATOR receiver
E2K93_RS03635	COG1404	Belongs to the peptidase S8 family
E2K93_RS03655	COG1132	(ABC) transporter
E2K93_RS03680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2K93_RS03690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E2K93_RS03710	COG0463	Glycosyl transferase, family 2
E2K93_RS03725	COG1216	Glycosyl transferase, family 2
E2K93_RS03725	COG1442	glycosyl transferase family 8
E2K93_RS03760	COG0798	PFAM Bile acid sodium symporter
E2K93_RS03765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E2K93_RS03775	COG1902	pentaerythritol trinitrate reductase activity
E2K93_RS03785	COG4232	protein-disulfide reductase activity
E2K93_RS03795	COG1979	alcohol dehydrogenase
E2K93_RS03800	COG2095	MarC family integral membrane protein
E2K93_RS03805	COG0823	Involved in the tonB-independent uptake of proteins
E2K93_RS03805	COG4946	Tricorn protease homolog
E2K93_RS03805	COG1506	peptidase
E2K93_RS03815	COG1119	ATPase activity
E2K93_RS03820	COG1304	FMN binding
E2K93_RS03825	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2K93_RS03835	COG0738	Major facilitator superfamily
E2K93_RS03855	COG2721	sulfolactate sulfo-lyase activity
E2K93_RS03885	COG3119	arylsulfatase activity
E2K93_RS03890	COG3119	arylsulfatase activity
E2K93_RS03895	COG3408	Glycogen debranching enzyme
E2K93_RS03895	COG3119	arylsulfatase activity
E2K93_RS03900	COG3119	arylsulfatase activity
E2K93_RS03905	COG3119	arylsulfatase activity
E2K93_RS03915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E2K93_RS03915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E2K93_RS03920	COG0509	glycine decarboxylation via glycine cleavage system
E2K93_RS03925	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E2K93_RS03930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K93_RS03940	COG1538	Outer membrane efflux protein
E2K93_RS03945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K93_RS03950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K93_RS03955	COG0006	proline dipeptidase activity
E2K93_RS03960	COG3079	Belongs to the UPF0149 family
E2K93_RS03970	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E2K93_RS03975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E2K93_RS03980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E2K93_RS03985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2K93_RS03990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E2K93_RS04010	COG3706	GGDEF domain
E2K93_RS04015	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E2K93_RS04020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E2K93_RS04025	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E2K93_RS04030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E2K93_RS04035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2K93_RS04045	COG0513	Belongs to the DEAD box helicase family
E2K93_RS04065	COG3022	response to hydroperoxide
E2K93_RS04070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E2K93_RS04080	COG1272	protein, Hemolysin III
E2K93_RS04085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2K93_RS04095	COG1131	(ABC) transporter
E2K93_RS04100	COG1444	tRNA N-acetyltransferase activity
E2K93_RS04105	COG4459	periplasmic nitrate reductase
E2K93_RS04110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2K93_RS04120	COG0243	molybdopterin cofactor binding
E2K93_RS04125	COG3043	anaerobic respiration
E2K93_RS04130	COG3005	denitrification pathway
E2K93_RS04140	COG0303	'Molybdopterin
E2K93_RS04150	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E2K93_RS04155	COG0746	molybdenum cofactor guanylyltransferase activity
E2K93_RS04160	COG0521	Mo-molybdopterin cofactor biosynthetic process
E2K93_RS04165	COG0315	cyclic pyranopterin monophosphate synthase activity
E2K93_RS04175	COG0314	molybdopterin synthase activity
E2K93_RS04190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E2K93_RS04195	COG3130	regulation of translation
E2K93_RS04200	COG3530	Putative quorum-sensing-regulated virulence factor
E2K93_RS04205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2K93_RS04210	COG3118	belongs to the thioredoxin family
E2K93_RS04260	COG3047	cAMP biosynthetic process
E2K93_RS04260	COG2885	chlorophyll binding
E2K93_RS04265	COG0745	RESPONSE REGULATOR receiver
E2K93_RS04270	COG2205	protein histidine kinase activity
E2K93_RS04280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E2K93_RS04295	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E2K93_RS04305	COG0302	gtp cyclohydrolase
E2K93_RS04320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2K93_RS04335	COG4221	oxidoreductase activity
E2K93_RS04345	COG0415	Belongs to the DNA photolyase family
E2K93_RS04355	COG3806	Anti-sigma factor
E2K93_RS04360	COG1595	DNA-templated transcription, initiation
E2K93_RS04370	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E2K93_RS04375	COG3040	lipid binding
E2K93_RS04380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K93_RS04385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K93_RS04420	COG0788	formyltetrahydrofolate deformylase activity
E2K93_RS04440	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E2K93_RS04450	COG0800	Aldolase
E2K93_RS04455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2K93_RS04460	COG2271	Major facilitator Superfamily
E2K93_RS04495	COG2186	Transcriptional regulator
E2K93_RS04515	COG1454	alcohol dehydrogenase
E2K93_RS04520	COG0778	Nitroreductase
E2K93_RS04535	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E2K93_RS04535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E2K93_RS04540	COG1560	Kdo2-lipid A biosynthetic process
E2K93_RS04560	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E2K93_RS04600	COG4991	sh3 domain protein
E2K93_RS04610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E2K93_RS04625	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E2K93_RS04630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2K93_RS04635	COG0473	3-isopropylmalate dehydrogenase activity
E2K93_RS04640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2K93_RS04645	COG0066	3-isopropylmalate dehydratase activity
E2K93_RS04655	COG3267	Type II secretory pathway component ExeA
E2K93_RS04655	COG3409	Peptidoglycan-binding domain 1 protein
E2K93_RS04660	COG0617	tRNA 3'-terminal CCA addition
E2K93_RS04665	COG1832	CoA-binding protein
E2K93_RS04670	COG1968	undecaprenyl-diphosphatase activity
E2K93_RS04680	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E2K93_RS04685	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E2K93_RS04690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E2K93_RS04695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E2K93_RS04700	COG1610	YqeY-like protein
E2K93_RS04705	COG0358	DNA primase activity
E2K93_RS04725	COG3706	GGDEF domain
E2K93_RS04735	COG0582	viral genome integration into host DNA
E2K93_RS04775	COG1696	Membrane protein involved in D-alanine export
E2K93_RS04810	COG1404	Belongs to the peptidase S8 family
E2K93_RS04830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E2K93_RS04850	COG0741	lytic transglycosylase activity
E2K93_RS04870	COG0733	neurotransmitter:sodium symporter activity
E2K93_RS04875	COG0116	Belongs to the methyltransferase superfamily
E2K93_RS04875	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E2K93_RS04880	COG1280	lysine exporter protein (LysE YggA)
E2K93_RS04885	COG1793	dna ligase
E2K93_RS04905	COG2827	Endonuclease containing a URI domain
E2K93_RS04920	COG3842	ATPase activity
E2K93_RS04930	COG1840	ABC-type Fe3 transport system, periplasmic component
E2K93_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_RS04985	COG4948	Mandelate Racemase Muconate Lactonizing
E2K93_RS04995	COG1388	LysM domain
E2K93_RS04995	COG1376	ErfK ybiS ycfS ynhG family protein
E2K93_RS05040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2K93_RS05055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2K93_RS05065	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E2K93_RS05070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E2K93_RS05090	COG3141	response to X-ray
E2K93_RS05110	COG1473	amidohydrolase
E2K93_RS05125	COG1404	Belongs to the peptidase S8 family
E2K93_RS05125	COG1404	Belongs to the peptidase S8 family
E2K93_RS05140	COG0583	DNA-binding transcription factor activity
E2K93_RS05155	COG2203	Gaf domain
E2K93_RS05155	COG3706	GGDEF domain
E2K93_RS05155	COG4251	negative regulation of phosphorylation
E2K93_RS05155	COG5001	Diguanylate cyclase
E2K93_RS05165	COG0823	Involved in the tonB-independent uptake of proteins
E2K93_RS05165	COG4946	Tricorn protease homolog
E2K93_RS05165	COG1506	peptidase
E2K93_RS05170	COG0163	prenyltransferase activity
E2K93_RS05175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2K93_RS05185	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E2K93_RS05200	COG4459	periplasmic nitrate reductase
E2K93_RS05205	COG3005	denitrification pathway
E2K93_RS05210	COG0243	molybdopterin cofactor binding
E2K93_RS05215	COG3381	protein complex oligomerization
E2K93_RS05245	COG0183	Belongs to the thiolase family
E2K93_RS05250	COG1024	Enoyl-CoA hydratase
E2K93_RS05250	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2K93_RS05255	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E2K93_RS05260	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E2K93_RS05265	COG0175	sulfate reduction
E2K93_RS05270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2K93_RS05275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E2K93_RS05305	COG1842	Phage shock protein A
E2K93_RS05325	COG0735	belongs to the Fur family
E2K93_RS05335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E2K93_RS05340	COG0305	Participates in initiation and elongation during chromosome replication
E2K93_RS05345	COG2719	SpoVR family
E2K93_RS05350	COG2718	Belongs to the UPF0229 family
E2K93_RS05355	COG2766	serine protein kinase
E2K93_RS05370	COG1595	DNA-templated transcription, initiation
E2K93_RS05375	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E2K93_RS05385	COG1984	allophanate hydrolase subunit 2
E2K93_RS05390	COG2832	Protein of unknown function (DUF454)
E2K93_RS05395	COG4807	Protein conserved in bacteria
E2K93_RS05405	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E2K93_RS05410	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E2K93_RS05420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E2K93_RS05425	COG0254	rRNA binding
E2K93_RS05445	COG0339	signal peptide processing
E2K93_RS05460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2K93_RS05475	COG1741	Belongs to the pirin family
E2K93_RS05485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E2K93_RS05490	COG2986	histidine ammonia-lyase
E2K93_RS05505	COG0435	Glutathione S-transferase
E2K93_RS05515	COG0037	tRNA processing
E2K93_RS05535	COG0330	HflC and HflK could
E2K93_RS05540	COG0330	HflC and HflK could
E2K93_RS05550	COG2133	pyrroloquinoline quinone binding
E2K93_RS05560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2K93_RS05565	COG0456	acetyltransferase
E2K93_RS05570	COG1490	D-aminoacyl-tRNA deacylase activity
E2K93_RS05580	COG1295	ribonuclease BN
E2K93_RS05610	COG1217	gtp-binding protein TYPA
E2K93_RS05615	COG0174	glutamine synthetase
E2K93_RS05625	COG3852	Histidine kinase
E2K93_RS05640	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E2K93_RS05645	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E2K93_RS05650	COG1509	lysine 2,3-aminomutase activity
E2K93_RS05675	COG0459	protein refolding
E2K93_RS05680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E2K93_RS05690	COG1324	tolerance protein
E2K93_RS05695	COG4232	protein-disulfide reductase activity
E2K93_RS05705	COG0511	ligase activity, forming carbon-carbon bonds
E2K93_RS05710	COG0439	Biotin carboxylase
E2K93_RS05735	COG2814	Major facilitator Superfamily
E2K93_RS05740	COG0633	Ferredoxin
E2K93_RS05740	COG3217	Mosc domain protein beta barrel domain protein
E2K93_RS05755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2K93_RS05765	COG1012	belongs to the aldehyde dehydrogenase family
E2K93_RS05775	COG1966	Carbon starvation protein
E2K93_RS05780	COG1765	OsmC-like protein
E2K93_RS05790	COG3954	Phosphoribulokinase
E2K93_RS05795	COG0203	ribosomal protein L17
E2K93_RS05800	COG0202	RNA polymerase activity
E2K93_RS05810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E2K93_RS05815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E2K93_RS05825	COG0201	protein transport
E2K93_RS05830	COG0200	Binds to the 23S rRNA
E2K93_RS05835	COG1841	ribosomal large subunit assembly
E2K93_RS05840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E2K93_RS05845	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E2K93_RS05850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E2K93_RS05855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E2K93_RS05860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E2K93_RS05865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E2K93_RS05870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E2K93_RS05890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E2K93_RS05895	COG0255	Belongs to the universal ribosomal protein uL29 family
E2K93_RS05900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E2K93_RS05905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E2K93_RS05910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E2K93_RS05915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E2K93_RS05920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E2K93_RS05925	COG0089	rRNA binding
E2K93_RS05930	COG0088	Forms part of the polypeptide exit tunnel
E2K93_RS05935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E2K93_RS05940	COG0051	transcription antitermination factor activity, RNA binding
E2K93_RS05945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E2K93_RS05960	COG0446	pyridine nucleotide-disulphide oxidoreductase
E2K93_RS05960	COG1902	pentaerythritol trinitrate reductase activity
E2K93_RS05965	COG3314	Sporulation integral membrane protein YlbJ
E2K93_RS05970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E2K93_RS05995	COG0668	transmembrane transport
E2K93_RS06030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2K93_RS06035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2K93_RS06045	COG4772	TonB-dependent receptor
E2K93_RS06050	COG0640	Transcriptional regulator
E2K93_RS06055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K93_RS06075	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E2K93_RS06085	COG2175	clavaminate synthase activity
E2K93_RS06095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2K93_RS06100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2K93_RS06105	COG0049	tRNA binding
E2K93_RS06110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E2K93_RS06115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E2K93_RS06120	COG0085	RNA polymerase activity
E2K93_RS06125	COG0222	ribosome binding
E2K93_RS06130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E2K93_RS06135	COG0081	regulation of translation
E2K93_RS06140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E2K93_RS06150	COG0250	Participates in transcription elongation, termination and antitermination
E2K93_RS06180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2K93_RS06210	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E2K93_RS06210	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E2K93_RS06215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E2K93_RS06220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E2K93_RS06235	COG0545	Peptidyl-prolyl cis-trans isomerase
E2K93_RS06240	COG2900	Belongs to the SlyX family
E2K93_RS06245	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E2K93_RS06250	COG0488	(ABC) transporter
E2K93_RS06255	COG2824	Alkylphosphonate utilization operon protein PhnA
E2K93_RS06265	COG0429	hydrolase of the alpha beta-hydrolase fold
E2K93_RS06280	COG1218	3'(2'),5'-bisphosphate nucleotidase
E2K93_RS06285	COG0494	nUDIX hydrolase
E2K93_RS06290	COG1011	Hydrolase
E2K93_RS06295	COG2195	Cleaves the N-terminal amino acid of tripeptides
E2K93_RS06300	COG1309	transcriptional regulator
E2K93_RS06305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E2K93_RS06310	COG2003	Belongs to the UPF0758 family
E2K93_RS06315	COG2321	neutral zinc metallopeptidase
E2K93_RS06320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E2K93_RS06325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E2K93_RS06330	COG1704	LemA family
E2K93_RS06335	COG0501	Belongs to the peptidase M48B family
E2K93_RS06340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E2K93_RS06345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E2K93_RS06350	COG1309	transcriptional regulator
E2K93_RS06355	COG3642	lipopolysaccharide core region biosynthetic process
E2K93_RS06360	COG0859	PFAM glycosyl transferase family 9
E2K93_RS06380	COG1519	Transferase
E2K93_RS06390	COG1063	alcohol dehydrogenase
E2K93_RS06395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2K93_RS06420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E2K93_RS06430	COG0514	ATP-dependent DNA helicase (RecQ)
E2K93_RS06435	COG2050	protein possibly involved in aromatic compounds catabolism
E2K93_RS06440	COG2962	Rard protein
E2K93_RS06460	COG1404	Belongs to the peptidase S8 family
E2K93_RS06490	COG2271	Major facilitator Superfamily
E2K93_RS06495	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2K93_RS06510	COG4269	membrane
E2K93_RS06515	COG0210	DNA helicase
E2K93_RS06525	COG1011	Hydrolase
E2K93_RS06535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E2K93_RS06540	COG0019	diaminopimelate decarboxylase activity
E2K93_RS06550	COG1965	Belongs to the frataxin family
E2K93_RS06555	COG0181	hydroxymethylbilane synthase activity
E2K93_RS06565	COG2959	enzyme of heme biosynthesis
E2K93_RS06590	COG0583	DNA-binding transcription factor activity
E2K93_RS06620	COG1006	Multisubunit Na H antiporter MnhC subunit
E2K93_RS06625	COG0651	ATP synthesis coupled electron transport
E2K93_RS06630	COG0651	ATP synthesis coupled electron transport
E2K93_RS06640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E2K93_RS06640	COG2111	Na H antiporter
E2K93_RS06660	COG2937	Belongs to the GPAT DAPAT family
E2K93_RS06675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E2K93_RS06680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E2K93_RS06685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2K93_RS06690	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E2K93_RS06715	COG1612	heme a metabolic process
E2K93_RS06720	COG0109	protoheme IX farnesyltransferase activity
E2K93_RS06730	COG0217	transcriptional regulatory protein
E2K93_RS06740	COG0625	glutathione transferase activity
E2K93_RS06745	COG0726	polysaccharide deacetylase
E2K93_RS06750	COG0534	Mate efflux family protein
E2K93_RS06755	COG2814	Major facilitator Superfamily
E2K93_RS06760	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E2K93_RS06760	COG0316	Belongs to the HesB IscA family
E2K93_RS06770	COG1040	competence protein
E2K93_RS06775	COG0596	Alpha beta hydrolase
E2K93_RS06785	COG0668	transmembrane transport
E2K93_RS06800	COG0583	DNA-binding transcription factor activity
E2K93_RS06810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E2K93_RS06815	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E2K93_RS06835	COG1561	YicC-like family, N-terminal region
E2K93_RS06845	COG3132	Protein of unknown function, DUF480
E2K93_RS06855	COG0583	DNA-binding transcription factor activity
E2K93_RS06865	COG2207	Transcriptional regulator
E2K93_RS06865	COG1917	Cupin 2, conserved barrel domain protein
E2K93_RS06870	COG1346	cytolysis
E2K93_RS06885	COG0668	transmembrane transport
E2K93_RS06910	COG2193	ferroxidase activity
E2K93_RS06930	COG1448	Aminotransferase
E2K93_RS06945	COG0194	GDP metabolic process
E2K93_RS06950	COG1758	RNA polymerase activity
E2K93_RS06955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2K93_RS06965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2K93_RS06970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E2K93_RS06975	COG2226	methyltransferase
E2K93_RS06995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2K93_RS07000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2K93_RS07005	COG0805	protein transport
E2K93_RS07030	COG0248	Ppx GppA phosphatase
E2K93_RS07040	COG3118	belongs to the thioredoxin family
E2K93_RS07050	COG1187	pseudouridine synthase activity
E2K93_RS07055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E2K93_RS07060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E2K93_RS07065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E2K93_RS07070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2K93_RS07075	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E2K93_RS07080	COG4942	peptidase
E2K93_RS07090	COG2861	carbohydrate metabolic process
E2K93_RS07095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2K93_RS07155	COG0482	sulfurtransferase activity
E2K93_RS07180	COG1045	serine acetyltransferase
E2K93_RS07185	COG0438	transferase activity, transferring glycosyl groups
E2K93_RS07195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E2K93_RS07200	COG1596	polysaccharide export
E2K93_RS07210	COG0489	protein tyrosine kinase activity
E2K93_RS07220	COG3409	Peptidoglycan-binding domain 1 protein
E2K93_RS07220	COG3267	Type II secretory pathway component ExeA
E2K93_RS07225	COG2204	response regulator
E2K93_RS07230	COG4191	Histidine kinase
E2K93_RS07245	COG0745	RESPONSE REGULATOR receiver
E2K93_RS07250	COG4251	negative regulation of phosphorylation
E2K93_RS07260	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_RS07265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E2K93_RS07300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2K93_RS07320	COG3618	amidohydrolase
E2K93_RS07330	COG0457	Tetratricopeptide repeat
E2K93_RS07345	COG3119	arylsulfatase activity
E2K93_RS07355	COG3119	arylsulfatase activity
E2K93_RS07360	COG3119	arylsulfatase activity
E2K93_RS07370	COG1802	Transcriptional regulator
E2K93_RS07385	COG4948	Mandelate Racemase Muconate Lactonizing
E2K93_RS07390	COG1012	belongs to the aldehyde dehydrogenase family
E2K93_RS07410	COG0330	HflC and HflK could
E2K93_RS07425	COG3119	arylsulfatase activity
E2K93_RS07430	COG3119	arylsulfatase activity
E2K93_RS07435	COG3734	2-keto-3-deoxy-galactonokinase
E2K93_RS07445	COG2017	converts alpha-aldose to the beta-anomer
E2K93_RS07460	COG0800	Aldolase
E2K93_RS07465	COG3734	2-keto-3-deoxy-galactonokinase
E2K93_RS07470	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_RS07475	COG3119	arylsulfatase activity
E2K93_RS07490	COG3250	beta-galactosidase activity
E2K93_RS07500	COG2706	6-phosphogluconolactonase activity
E2K93_RS07515	COG3119	arylsulfatase activity
E2K93_RS07530	COG3119	arylsulfatase activity
E2K93_RS07560	COG3250	beta-galactosidase activity
E2K93_RS07570	COG3119	arylsulfatase activity
E2K93_RS07595	COG3119	arylsulfatase activity
E2K93_RS07600	COG3119	arylsulfatase activity
E2K93_RS07605	COG3250	beta-galactosidase activity
E2K93_RS07610	COG3119	arylsulfatase activity
E2K93_RS07620	COG3119	arylsulfatase activity
E2K93_RS07625	COG3250	beta-galactosidase activity
E2K93_RS07635	COG2186	Transcriptional regulator
E2K93_RS07640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2K93_RS07645	COG1085	galactose-1-phosphate uridylyltransferase
E2K93_RS07650	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E2K93_RS07670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2K93_RS07705	COG1349	DNA-binding transcription factor activity
E2K93_RS07710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2K93_RS07720	COG0625	glutathione transferase activity
E2K93_RS07725	COG3265	gluconokinase activity
E2K93_RS07730	COG0673	inositol 2-dehydrogenase activity
E2K93_RS07740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2K93_RS07750	COG0640	Transcriptional regulator
E2K93_RS07755	COG0678	peroxiredoxin activity
E2K93_RS07755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E2K93_RS07760	COG4628	conserved protein (DUF2132)
E2K93_RS07785	COG2095	MarC family integral membrane protein
E2K93_RS07795	COG3068	Protein conserved in bacteria
E2K93_RS07800	COG3360	Dodecin
E2K93_RS07805	COG0742	ribosomal rna small subunit methyltransferase
E2K93_RS07810	COG0552	protein localization to endoplasmic reticulum
E2K93_RS07815	COG2884	Cell division ATP-binding protein ftsE
E2K93_RS07820	COG2177	Part of the ABC transporter FtsEX involved in
E2K93_RS07840	COG0210	DNA helicase
E2K93_RS07855	COG0129	dihydroxy-acid dehydratase activity
E2K93_RS07870	COG0606	chelatase, subunit chli
E2K93_RS07880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E2K93_RS07885	COG0252	asparaginase activity
E2K93_RS07890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E2K93_RS07895	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E2K93_RS07900	COG0668	transmembrane transport
E2K93_RS07905	COG1946	Acyl-CoA thioesterase
E2K93_RS07935	COG0295	cytidine deaminase activity
E2K93_RS07965	COG1082	Xylose isomerase domain protein TIM barrel
E2K93_RS07990	COG4989	oxidoreductase activity
E2K93_RS08005	COG1476	TRANSCRIPTIONal
E2K93_RS08025	COG1640	4-alpha-glucanotransferase
E2K93_RS08035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E2K93_RS08040	COG0058	SHG alpha-glucan phosphorylase activity
E2K93_RS08055	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2K93_RS08100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E2K93_RS08105	COG0662	Cupin 2, conserved barrel domain protein
E2K93_RS08140	COG3738	Protein conserved in bacteria
E2K93_RS08145	COG0384	phenazine biosynthesis protein PhzF
E2K93_RS08185	COG2264	protein methyltransferase activity
E2K93_RS08190	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
E2K93_RS08215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E2K93_RS08255	COG0726	polysaccharide deacetylase
E2K93_RS08295	COG1671	Belongs to the UPF0178 family
E2K93_RS08300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E2K93_RS08325	COG3064	Membrane
E2K93_RS08340	COG0633	Ferredoxin
E2K93_RS08350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E2K93_RS08360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E2K93_RS08365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E2K93_RS08370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E2K93_RS08390	COG1475	DNA binding
E2K93_RS08395	COG1192	Involved in chromosome partitioning
E2K93_RS08400	COG0357	Ribosomal RNA small subunit methyltransferase G
E2K93_RS08405	COG0445	tRNA wobble uridine modification
E2K93_RS08410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E2K93_RS08415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E2K93_RS08420	COG0706	membrane insertase activity
E2K93_RS08425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E2K93_RS08430	COG0594	ribonuclease P activity
E2K93_RS08435	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E2K93_RS08440	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E2K93_RS08445	COG0592	DNA-directed DNA polymerase activity
E2K93_RS08455	COG0187	DNA topoisomerase II activity
E2K93_RS08460	COG0752	glycyl-tRNA synthetase alpha subunit
E2K93_RS08465	COG0751	glycine-tRNA ligase activity
E2K93_RS08470	COG0425	Belongs to the sulfur carrier protein TusA family
E2K93_RS08480	COG0006	proline dipeptidase activity
E2K93_RS08485	COG1739	Uncharacterized protein family UPF0029
E2K93_RS08490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E2K93_RS08495	COG0569	domain protein
E2K93_RS08500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2K93_RS08500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2K93_RS08520	COG0758	DNA mediated transformation
E2K93_RS08525	COG2922	Belongs to the Smg family
E2K93_RS08540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E2K93_RS08560	COG3083	sulfuric ester hydrolase activity
E2K93_RS08565	COG3047	cAMP biosynthetic process
E2K93_RS08580	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E2K93_RS08625	COG3078	GTPase activator activity
E2K93_RS08650	COG2199	diguanylate cyclase activity
E2K93_RS08660	COG0189	ligase activity
E2K93_RS08675	COG0745	RESPONSE REGULATOR receiver
E2K93_RS08675	COG2205	protein histidine kinase activity
E2K93_RS08675	COG3292	Two component regulator propeller
E2K93_RS08695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E2K93_RS08705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E2K93_RS08705	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E2K93_RS08710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2K93_RS08725	COG0742	ribosomal rna small subunit methyltransferase
E2K93_RS08735	COG0450	alkyl hydroperoxide reductase
E2K93_RS08740	COG0583	DNA-binding transcription factor activity
E2K93_RS08750	COG0678	peroxiredoxin activity
E2K93_RS08755	COG1528	Iron-storage protein
E2K93_RS08760	COG2081	HI0933 family
E2K93_RS08800	COG1472	Belongs to the glycosyl hydrolase 3 family
E2K93_RS08815	COG0668	transmembrane transport
E2K93_RS08820	COG0352	thiamine-phosphate diphosphorylase activity
E2K93_RS08820	COG0351	phosphomethylpyrimidine kinase
E2K93_RS08850	COG0346	lactoylglutathione lyase activity
E2K93_RS08885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2K93_RS08920	COG1335	isochorismatase
E2K93_RS08940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2K93_RS08950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2K93_RS08970	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_RS08975	COG2814	Major facilitator Superfamily
E2K93_RS08995	COG1960	acyl-CoA dehydrogenase activity
E2K93_RS09005	COG1012	belongs to the aldehyde dehydrogenase family
E2K93_RS09015	COG1335	isochorismatase
E2K93_RS09025	COG4774	siderophore transport
E2K93_RS09060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2K93_RS09065	COG0066	3-isopropylmalate dehydratase activity
E2K93_RS09095	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_RS09110	COG0477	Major facilitator Superfamily
E2K93_RS09120	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_RS09130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2K93_RS09130	COG3153	acetyltransferase
E2K93_RS09150	COG2188	Transcriptional regulator
E2K93_RS09170	COG0457	Tetratricopeptide repeat
E2K93_RS09175	COG4771	TonB-dependent receptor
E2K93_RS09185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2K93_RS09210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2K93_RS09235	COG0154	amidase activity
E2K93_RS09240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2K93_RS09250	COG1944	ATP diphosphatase activity
E2K93_RS09275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2K93_RS09280	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2K93_RS09280	COG1024	Enoyl-CoA hydratase
E2K93_RS09300	COG1012	belongs to the aldehyde dehydrogenase family
E2K93_RS09350	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_RS09360	COG2301	Belongs to the HpcH HpaI aldolase family
E2K93_RS09370	COG1960	acyl-CoA dehydrogenase activity
E2K93_RS09375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2K93_RS09380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2K93_RS09395	COG0277	FAD linked oxidase domain protein
E2K93_RS09405	COG2130	NADP-dependent
E2K93_RS09410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2K93_RS09440	COG2030	dehydratase
E2K93_RS09445	COG2301	Belongs to the HpcH HpaI aldolase family
E2K93_RS09510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E2K93_RS09520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2K93_RS09525	COG1228	amidohydrolase
E2K93_RS09530	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E2K93_RS09535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E2K93_RS09545	COG2267	carboxylic ester hydrolase activity
E2K93_RS09550	COG2205	protein histidine kinase activity
E2K93_RS09555	COG0745	RESPONSE REGULATOR receiver
E2K93_RS09585	COG1929	Belongs to the glycerate kinase type-1 family
E2K93_RS09590	COG2183	response to ionizing radiation
E2K93_RS09595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2K93_RS09615	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E2K93_RS09620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E2K93_RS09625	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E2K93_RS09630	COG3031	protein transport across the cell outer membrane
E2K93_RS09640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E2K93_RS09645	COG1459	type II secretion system
E2K93_RS09650	COG2165	general secretion pathway protein
E2K93_RS09660	COG2165	general secretion pathway protein
E2K93_RS09665	COG4795	General secretion pathway protein
E2K93_RS09670	COG3156	type II secretion system protein K
E2K93_RS09680	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E2K93_RS09690	COG0584	glycerophosphoryl diester phosphodiesterase
E2K93_RS09695	COG0688	phosphatidylethanolamine metabolic process
E2K93_RS09700	COG1162	GTPase activity
E2K93_RS09705	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E2K93_RS09725	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E2K93_RS09730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E2K93_RS09730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E2K93_RS09735	COG0802	atpase or kinase
E2K93_RS09740	COG0860	N-Acetylmuramoyl-L-alanine amidase
E2K93_RS09750	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E2K93_RS09755	COG1923	regulation of RNA biosynthetic process
E2K93_RS09760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E2K93_RS09765	COG0330	HflC and HflK could
E2K93_RS09770	COG0330	HflC and HflK could
E2K93_RS09775	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E2K93_RS09780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E2K93_RS09800	COG0281	malic enzyme
E2K93_RS09805	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
E2K93_RS09810	COG0626	cystathionine gamma-synthase activity
E2K93_RS09815	COG0460	homoserine dehydrogenase
E2K93_RS09815	COG0527	aspartate kinase activity
E2K93_RS09830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E2K93_RS09835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E2K93_RS09840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E2K93_RS09845	COG0137	argininosuccinate synthase activity
E2K93_RS09855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E2K93_RS09885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E2K93_RS09890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E2K93_RS09895	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E2K93_RS09910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E2K93_RS09925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2K93_RS09945	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E2K93_RS09970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E2K93_RS09995	COG3038	cytochrome b561
E2K93_RS10000	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E2K93_RS10005	COG0583	DNA-binding transcription factor activity
E2K93_RS10020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E2K93_RS10030	COG4783	chaperone-mediated protein folding
E2K93_RS10045	COG1648	precorrin-2 dehydrogenase activity
E2K93_RS10045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2K93_RS10050	COG2264	protein methyltransferase activity
E2K93_RS10060	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E2K93_RS10065	COG0138	bifunctional purine biosynthesis protein purh
E2K93_RS10075	COG0151	Belongs to the GarS family
E2K93_RS10080	COG0724	RNA recognition motif
E2K93_RS10140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2K93_RS10155	COG2814	Major facilitator Superfamily
E2K93_RS10165	COG1131	(ABC) transporter
E2K93_RS10170	COG0842	Transport permease protein
E2K93_RS10175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E2K93_RS10180	COG0438	transferase activity, transferring glycosyl groups
E2K93_RS10185	COG1301	dicarboxylic acid transport
E2K93_RS10190	COG0076	glutamate decarboxylase activity
E2K93_RS10195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E2K93_RS10205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E2K93_RS10210	COG0617	tRNA 3'-terminal CCA addition
E2K93_RS10225	COG1489	DNA binding
E2K93_RS10235	COG0668	transmembrane transport
E2K93_RS10250	COG1643	Atp-dependent helicase
E2K93_RS10255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E2K93_RS10260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E2K93_RS10265	COG0540	Belongs to the ATCase OTCase family
E2K93_RS10270	COG1981	membrane
E2K93_RS10275	COG0038	chloride channel
E2K93_RS10285	COG0316	Belongs to the HesB IscA family
E2K93_RS10320	COG0557	exoribonuclease II activity
E2K93_RS10325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2K93_RS10330	COG0360	Binds together with S18 to 16S ribosomal RNA
E2K93_RS10335	COG2965	DNA replication, synthesis of RNA primer
E2K93_RS10340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E2K93_RS10345	COG0359	binds to the 23S rRNA
E2K93_RS10365	COG1077	Cell shape determining protein MreB Mrl
E2K93_RS10370	COG1792	Involved in formation and maintenance of cell shape
E2K93_RS10375	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E2K93_RS10380	COG0424	maF-like protein
E2K93_RS10385	COG1530	ribonuclease E activity
E2K93_RS10395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2K93_RS10400	COG0312	modulator of DNA gyrase
E2K93_RS10410	COG0312	modulator of DNA gyrase
E2K93_RS10415	COG2239	Acts as a magnesium transporter
E2K93_RS10420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E2K93_RS10425	COG1660	Displays ATPase and GTPase activities
E2K93_RS10430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E2K93_RS10435	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E2K93_RS10440	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E2K93_RS10445	COG1137	ATPase activity
E2K93_RS10460	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E2K93_RS10485	COG1127	ABC transporter
E2K93_RS10490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E2K93_RS10495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E2K93_RS10500	COG2854	intermembrane phospholipid transfer
E2K93_RS10510	COG5007	Belongs to the BolA IbaG family
E2K93_RS10515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E2K93_RS10525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2K93_RS10535	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E2K93_RS10540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E2K93_RS10545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E2K93_RS10550	COG0723	plastoquinol--plastocyanin reductase activity
E2K93_RS10555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E2K93_RS10560	COG2857	Cytochrome c1
E2K93_RS10565	COG0625	glutathione transferase activity
E2K93_RS10570	COG2969	positive regulation of protein catabolic process
E2K93_RS10585	COG2823	Periplasmic or secreted lipoprotein
E2K93_RS10590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E2K93_RS10595	COG0792	nuclease activity
E2K93_RS10605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E2K93_RS10625	COG0415	Belongs to the DNA photolyase family
E2K93_RS10640	COG2610	gluconate transmembrane transporter activity
E2K93_RS10650	COG3137	Salt-induced outer membrane protein
E2K93_RS10655	COG2205	protein histidine kinase activity
E2K93_RS10655	COG5002	protein histidine kinase activity
E2K93_RS10655	COG0784	Response regulator, receiver
E2K93_RS10660	COG0166	Belongs to the GPI family
E2K93_RS10665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E2K93_RS10670	COG2001	Belongs to the MraZ family
E2K93_RS10675	COG0275	rRNA processing
E2K93_RS10685	COG0768	penicillin binding
E2K93_RS10695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E2K93_RS10700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2K93_RS10710	COG0772	Belongs to the SEDS family
E2K93_RS10730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E2K93_RS10735	COG0849	cell division
E2K93_RS10740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E2K93_RS10745	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E2K93_RS10755	COG0739	heme binding
E2K93_RS10760	COG0653	protein targeting
E2K93_RS10775	COG0583	DNA-binding transcription factor activity
E2K93_RS10790	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E2K93_RS10805	COG1459	type II secretion system
E2K93_RS10810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E2K93_RS10845	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E2K93_RS10850	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2K93_RS10855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2K93_RS10885	COG1049	propionate catabolic process, 2-methylcitrate cycle
E2K93_RS10900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K93_RS10920	COG0004	ammonium transporteR
E2K93_RS10935	COG0039	L-malate dehydrogenase activity
E2K93_RS10940	COG1438	arginine binding
E2K93_RS10945	COG2837	iron assimilation
E2K93_RS10955	COG2967	ApaG domain
E2K93_RS10960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E2K93_RS10965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E2K93_RS10970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2K93_RS10975	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E2K93_RS10980	COG3178	'Phosphotransferase
E2K93_RS10990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E2K93_RS11000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E2K93_RS11005	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E2K93_RS11015	COG2072	flavoprotein involved in K transport
E2K93_RS11020	COG1960	acyl-CoA dehydrogenase activity
E2K93_RS11025	COG0745	RESPONSE REGULATOR receiver
E2K93_RS11030	COG0848	biopolymer transport protein
E2K93_RS11045	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E2K93_RS11050	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2K93_RS11055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2K93_RS11060	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2K93_RS11070	COG1138	Cytochrome C-type biogenesis protein
E2K93_RS11095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E2K93_RS11100	COG0659	secondary active sulfate transmembrane transporter activity
E2K93_RS11105	COG3313	Fe-S protein
E2K93_RS11115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E2K93_RS11155	COG3483	tryptophan 2,3-dioxygenase activity
E2K93_RS11160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K93_RS11165	COG3844	kynureninase activity
E2K93_RS11175	COG1917	Cupin 2, conserved barrel domain protein
E2K93_RS11190	COG0657	acetylesterase activity
E2K93_RS11195	COG0583	DNA-binding transcription factor activity
E2K93_RS11205	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E2K93_RS11210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2K93_RS11220	COG0531	amino acid
E2K93_RS11225	COG2957	Belongs to the agmatine deiminase family
E2K93_RS11230	COG0531	amino acid
E2K93_RS11235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E2K93_RS11250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2K93_RS11270	COG0405	Gamma-glutamyltransferase
E2K93_RS11275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E2K93_RS11280	COG1882	Formate acetyltransferase
E2K93_RS11285	COG0622	Phosphoesterase
E2K93_RS11315	COG0739	heme binding
E2K93_RS11320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E2K93_RS11340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2K93_RS11345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E2K93_RS11390	COG1215	transferase activity, transferring glycosyl groups
E2K93_RS11395	COG0561	phosphatase activity
E2K93_RS11400	COG0493	'glutamate synthase
E2K93_RS11405	COG0070	glutamate synthase
E2K93_RS11405	COG0069	glutamate synthase activity
E2K93_RS11405	COG0067	glutamate synthase
E2K93_RS11410	COG1469	GTP cyclohydrolase I activity
E2K93_RS11420	COG0745	RESPONSE REGULATOR receiver
E2K93_RS11440	COG1024	Enoyl-CoA hydratase
E2K93_RS11450	COG2996	Protein conserved in bacteria
E2K93_RS11485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E2K93_RS11490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E2K93_RS11495	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E2K93_RS11500	COG0142	geranyltranstransferase activity
E2K93_RS11530	COG0786	glutamate:sodium symporter activity
E2K93_RS11535	COG1301	dicarboxylic acid transport
E2K93_RS11545	COG1404	Belongs to the peptidase S8 family
E2K93_RS11555	COG0105	UTP biosynthetic process
E2K93_RS11560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E2K93_RS11575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E2K93_RS11580	COG0124	histidyl-tRNA synthetase
E2K93_RS11585	COG2976	Protein conserved in bacteria
E2K93_RS11590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2K93_RS11595	COG1160	GTP binding
E2K93_RS11600	COG1538	Outer membrane efflux protein
E2K93_RS11605	COG0494	nUDIX hydrolase
E2K93_RS11610	COG3151	Protein conserved in bacteria
E2K93_RS11620	COG3150	esterase
E2K93_RS11655	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E2K93_RS11665	COG0525	valine-tRNA ligase activity
E2K93_RS11670	COG2927	DNA polymerase III (CHI subunit)
E2K93_RS11675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E2K93_RS11680	COG0795	lipopolysaccharide-transporting ATPase activity
E2K93_RS11685	COG0795	lipopolysaccharide-transporting ATPase activity
E2K93_RS11715	COG0516	GMP reductase activity
E2K93_RS11715	COG0517	IMP dehydrogenase activity
E2K93_RS11720	COG0519	Catalyzes the synthesis of GMP from XMP
E2K93_RS11720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E2K93_RS11745	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E2K93_RS11755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2K93_RS11760	COG1104	cysteine desulfurase activity
E2K93_RS11765	COG2975	iron-sulfur cluster assembly
E2K93_RS11770	COG0281	malic enzyme
E2K93_RS11805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E2K93_RS11820	COG1280	lysine exporter protein (LysE YggA)
E2K93_RS11830	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E2K93_RS11835	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E2K93_RS11925	COG0047	phosphoribosylformylglycinamidine synthase activity
E2K93_RS11925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E2K93_RS11930	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E2K93_RS11935	COG0590	tRNA wobble adenosine to inosine editing
E2K93_RS11945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2K93_RS11950	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E2K93_RS11960	COG0762	integral membrane protein
E2K93_RS11965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E2K93_RS11970	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E2K93_RS11985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E2K93_RS11990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E2K93_RS11995	COG0189	ligase activity
E2K93_RS12015	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E2K93_RS12025	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E2K93_RS12030	COG1595	DNA-templated transcription, initiation
E2K93_RS12045	COG3086	response to oxidative stress
E2K93_RS12050	COG0481	GTPase activity
E2K93_RS12060	COG0571	ribonuclease III activity
E2K93_RS12070	COG1381	Involved in DNA repair and RecF pathway recombination
E2K93_RS12075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E2K93_RS12095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2K93_RS12100	COG3956	TIGRFAM MazG family protein
E2K93_RS12110	COG0432	Pfam Uncharacterised protein family UPF0047
E2K93_RS12115	COG0504	CTP synthase activity
E2K93_RS12130	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E2K93_RS12140	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E2K93_RS12150	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E2K93_RS12155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2K93_RS12160	COG1238	metal cluster binding
E2K93_RS12175	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E2K93_RS12180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E2K93_RS12190	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E2K93_RS12195	COG0646	methionine synthase
E2K93_RS12195	COG1410	methionine synthase
E2K93_RS12205	COG2137	regulation of response to DNA damage stimulus
E2K93_RS12210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2K93_RS12215	COG0527	aspartate kinase activity
E2K93_RS12220	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E2K93_RS12245	COG3119	arylsulfatase activity
E2K93_RS12250	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E2K93_RS12265	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
E2K93_RS12270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E2K93_RS12285	COG0513	Belongs to the DEAD box helicase family
E2K93_RS12290	COG2814	Major facilitator Superfamily
E2K93_RS12320	COG0271	Belongs to the BolA IbaG family
E2K93_RS12330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2K93_RS12330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E2K93_RS12335	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E2K93_RS12340	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E2K93_RS12345	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E2K93_RS12355	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E2K93_RS12360	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E2K93_RS12365	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E2K93_RS12370	COG2871	sodium ion transport
E2K93_RS12375	COG1477	protein flavinylation
E2K93_RS12395	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E2K93_RS12410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E2K93_RS12505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E2K93_RS12520	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E2K93_RS12525	COG0560	Phosphoserine phosphatase
E2K93_RS12535	COG2326	polyphosphate kinase activity
E2K93_RS12540	COG0084	hydrolase, TatD family'
E2K93_RS12555	COG0018	arginyl-trna synthetase
E2K93_RS12560	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E2K93_RS12585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E2K93_RS12590	COG0343	queuine tRNA-ribosyltransferase activity
E2K93_RS12595	COG1862	Preprotein translocase
E2K93_RS12600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2K93_RS12605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2K93_RS12625	COG1794	racemase activity, acting on amino acids and derivatives
E2K93_RS12640	COG1288	antiporter activity
E2K93_RS12645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2K93_RS12645	COG1648	precorrin-2 dehydrogenase activity
E2K93_RS12655	COG0483	inositol monophosphate 1-phosphatase activity
E2K93_RS12670	COG1959	2 iron, 2 sulfur cluster binding
E2K93_RS12675	COG1104	cysteine desulfurase activity
E2K93_RS12680	COG0822	iron-sulfur transferase activity
E2K93_RS12695	COG0443	Heat shock 70 kDa protein
E2K93_RS12705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E2K93_RS12710	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E2K93_RS12715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2K93_RS12715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2K93_RS12730	COG2354	Protein conserved in bacteria
E2K93_RS12735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E2K93_RS12760	COG2066	Belongs to the glutaminase family
E2K93_RS12765	COG0544	peptidyl-prolyl cis-trans isomerase activity
E2K93_RS12770	COG0740	serine-type endopeptidase activity
E2K93_RS12775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E2K93_RS12780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E2K93_RS12790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2K93_RS12805	COG1012	belongs to the aldehyde dehydrogenase family
E2K93_RS12830	COG0215	cysteine-tRNA ligase activity
E2K93_RS12840	COG3101	peptidyl-lysine hydroxylation
E2K93_RS12860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2K93_RS12870	COG0564	pseudouridine synthase activity
E2K93_RS12875	COG1757	Na H antiporter
E2K93_RS12895	COG4536	flavin adenine dinucleotide binding
E2K93_RS12900	COG4137	Cytochrome C assembly protein
E2K93_RS12905	COG0701	Predicted permease
E2K93_RS12910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E2K93_RS12920	COG3485	protocatechuate 3,4-dioxygenase
E2K93_RS12925	COG0697	spore germination
E2K93_RS12930	COG0228	four-way junction DNA binding
E2K93_RS12935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E2K93_RS12945	COG0335	large ribosomal subunit rRNA binding
E2K93_RS12955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2K93_RS12975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E2K93_RS12980	COG1605	Chorismate mutase
E2K93_RS12980	COG0287	Prephenate dehydrogenase
E2K93_RS13005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K93_RS13010	COG2824	Alkylphosphonate utilization operon protein PhnA
E2K93_RS13020	COG0077	Prephenate dehydratase
E2K93_RS13020	COG1605	Chorismate mutase
E2K93_RS13025	COG3122	Protein conserved in bacteria
E2K93_RS13035	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E2K93_RS13045	COG0564	pseudouridine synthase activity
E2K93_RS13060	COG0626	cystathionine gamma-synthase activity
E2K93_RS13070	COG0028	Belongs to the TPP enzyme family
E2K93_RS13075	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2K93_RS13080	COG0023	Translation Initiation Factor
E2K93_RS13100	COG0259	pyridoxamine-phosphate oxidase activity
E2K93_RS13105	COG0612	Peptidase, M16
E2K93_RS13110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E2K93_RS13115	COG0347	Belongs to the P(II) protein family
E2K93_RS13120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E2K93_RS13140	COG0303	'Molybdopterin
E2K93_RS13170	COG0243	molybdopterin cofactor binding
E2K93_RS13170	COG3383	formate dehydrogenase (NAD+) activity
E2K93_RS13175	COG0437	4 iron, 4 sulfur cluster binding
E2K93_RS13185	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2K93_RS13190	COG0564	pseudouridine synthase activity
E2K93_RS13200	COG0542	response to heat
E2K93_RS13235	COG1404	Belongs to the peptidase S8 family
E2K93_RS13255	COG5002	protein histidine kinase activity
E2K93_RS13255	COG3850	Histidine kinase
E2K93_RS13270	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E2K93_RS13280	COG1666	GTP binding
E2K93_RS13285	COG0457	Tetratricopeptide repeat
E2K93_RS13290	COG0653	protein targeting
E2K93_RS13295	COG0653	protein targeting
E2K93_RS13300	COG0733	neurotransmitter:sodium symporter activity
E2K93_RS13310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E2K93_RS13320	COG0101	tRNA pseudouridine synthase activity
E2K93_RS13325	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E2K93_RS13330	COG0285	dihydrofolate synthase activity
E2K93_RS13340	COG1286	toxin biosynthetic process
E2K93_RS13345	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E2K93_RS13355	COG4172	Belongs to the ABC transporter superfamily
E2K93_RS13360	COG4171	peptide transport system, permease
E2K93_RS13370	COG0747	negative chemotaxis
E2K93_RS13375	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E2K93_RS13380	COG1842	Phage shock protein A
E2K93_RS13390	COG1983	PspC domain protein
E2K93_RS13395	COG3106	COG3106 Predicted ATPase
E2K93_RS13400	COG3768	UPF0283 membrane protein
E2K93_RS13410	COG2154	pterin-4-alpha-carbinolamine dehydratase
E2K93_RS13420	COG0625	glutathione transferase activity
E2K93_RS13450	COG0730	response to heat
E2K93_RS13470	COG0811	peptide transport
E2K93_RS13475	COG0811	peptide transport
E2K93_RS13480	COG0848	biopolymer transport protein
E2K93_RS13495	COG0288	reversible hydration of carbon dioxide
E2K93_RS13500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2K93_RS13510	COG0159	tryptophan synthase activity
E2K93_RS13530	COG0512	Glutamine amidotransferase of anthranilate synthase
E2K93_RS13535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E2K93_RS13545	COG0009	L-threonylcarbamoyladenylate synthase
E2K93_RS13555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E2K93_RS13560	COG1187	pseudouridine synthase activity
E2K93_RS13575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E2K93_RS13585	COG3108	Peptidase M15
E2K93_RS13590	COG0668	transmembrane transport
E2K93_RS13595	COG0604	alcohol dehydrogenase
E2K93_RS13600	COG0583	DNA-binding transcription factor activity
E2K93_RS13605	COG3604	Transcriptional regulator
E2K93_RS13615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2K93_RS13615	COG1017	nitric oxide dioxygenase activity
E2K93_RS13620	COG2755	lipolytic protein G-D-S-L family
E2K93_RS13625	COG4771	TonB-dependent receptor
E2K93_RS13640	COG1858	cytochrome C peroxidase
E2K93_RS13685	COG0596	Alpha beta hydrolase
E2K93_RS13725	COG0494	nUDIX hydrolase
E2K93_RS13745	COG0724	RNA recognition motif
E2K93_RS13750	COG3097	Belongs to the UPF0267 family
E2K93_RS13770	COG0071	Belongs to the small heat shock protein (HSP20) family
E2K93_RS13780	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E2K93_RS13785	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E2K93_RS13790	COG0577	efflux transmembrane transporter activity
E2K93_RS13800	COG1136	(ABC) transporter
E2K93_RS13805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K93_RS13810	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E2K93_RS13815	COG4535	Mg2 and Co2 transporter CorC
E2K93_RS13825	COG1702	phosphate starvation-inducible protein PhoH
E2K93_RS13830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E2K93_RS13835	COG1454	alcohol dehydrogenase
E2K93_RS13840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2K93_RS13855	COG1595	DNA-templated transcription, initiation
E2K93_RS13880	COG0505	Belongs to the CarA family
E2K93_RS13890	COG2076	Multidrug Resistance protein
E2K93_RS13925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K93_RS13945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2K93_RS13950	COG1566	PFAM secretion protein HlyD family protein
E2K93_RS13960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E2K93_RS13990	COG2971	BadF BadG BcrA BcrD
E2K93_RS13995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2K93_RS14000	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E2K93_RS14035	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E2K93_RS14040	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E2K93_RS14045	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E2K93_RS14050	COG1047	Peptidyl-prolyl cis-trans
E2K93_RS14060	COG1228	amidohydrolase
E2K93_RS14070	COG0697	spore germination
E2K93_RS14080	COG1115	amino acid carrier protein
E2K93_RS14085	COG0513	Belongs to the DEAD box helicase family
E2K93_RS14135	COG0745	RESPONSE REGULATOR receiver
E2K93_RS14140	COG2205	protein histidine kinase activity
E2K93_RS14145	COG1309	transcriptional regulator
E2K93_RS14155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2K93_RS14170	COG4770	biotin carboxylase activity
E2K93_RS14175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E2K93_RS14180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E2K93_RS14185	COG1960	acyl-CoA dehydrogenase activity
E2K93_RS14195	COG0183	Belongs to the thiolase family
E2K93_RS14200	COG1960	acyl-CoA dehydrogenase activity
E2K93_RS14205	COG1024	Enoyl-CoA hydratase
E2K93_RS14210	COG1024	Enoyl-CoA hydratase
E2K93_RS14220	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_RS14250	COG2176	DNA-directed DNA polymerase activity
E2K93_RS14255	COG3104	oligopeptide transport
E2K93_RS14265	COG0546	phosphoglycolate phosphatase activity
E2K93_RS14285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E2K93_RS14320	COG0183	Belongs to the thiolase family
E2K93_RS14325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2K93_RS14330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E2K93_RS14355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E2K93_RS14365	COG1278	Cold shock
E2K93_RS14380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E2K93_RS14385	COG0321	lipoyl(octanoyl) transferase activity
E2K93_RS14390	COG2921	Belongs to the UPF0250 family
E2K93_RS14400	COG1686	Belongs to the peptidase S11 family
E2K93_RS14405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E2K93_RS14415	COG0768	penicillin binding
E2K93_RS14420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E2K93_RS14430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E2K93_RS14435	COG1466	dna polymerase III delta subunit
E2K93_RS14440	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
E2K93_RS14445	COG0495	leucyl-tRNA aminoacylation
E2K93_RS14450	COG2888	peptidyl-tyrosine sulfation
E2K93_RS14455	COG1067	ATP-dependent peptidase activity
E2K93_RS14490	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2K93_RS14495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2K93_RS14500	COG0649	NAD binding
E2K93_RS14500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2K93_RS14520	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E2K93_RS14525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2K93_RS14530	COG0839	Belongs to the complex I subunit 6 family
E2K93_RS14540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E2K93_RS14550	COG1007	ATP synthesis coupled electron transport
E2K93_RS14585	COG0513	Belongs to the DEAD box helicase family
E2K93_RS14590	COG1024	Enoyl-CoA hydratase
E2K93_RS14600	COG0604	alcohol dehydrogenase
E2K93_RS14605	COG2171	N-acyltransferase activity
E2K93_RS14610	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E2K93_RS14615	COG0024	Methionine aminopeptidase
E2K93_RS14620	COG0052	Belongs to the universal ribosomal protein uS2 family
E2K93_RS14625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E2K93_RS14635	COG0528	UMP kinase activity
E2K93_RS14640	COG0233	cytoplasmic translational termination
E2K93_RS14645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E2K93_RS14650	COG0575	Belongs to the CDS family
E2K93_RS14655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E2K93_RS14660	COG0750	zinc metalloprotease
E2K93_RS14675	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2K93_RS14680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E2K93_RS14690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2K93_RS14705	COG0825	malonyl-CoA metabolic process
E2K93_RS14710	COG0037	tRNA processing
E2K93_RS14715	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E2K93_RS14720	COG3094	Invasion gene expression up-regulator, SirB
E2K93_RS14725	COG2912	Transglutaminase-like superfamily
E2K93_RS14735	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E2K93_RS14745	COG1803	Methylglyoxal synthase
E2K93_RS14755	COG0420	3'-5' exonuclease activity
E2K93_RS14760	COG0419	ATPase involved in DNA repair
E2K93_RS14770	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2K93_RS14775	COG2186	Transcriptional regulator
E2K93_RS14780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E2K93_RS14785	COG0450	alkyl hydroperoxide reductase
E2K93_RS14795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E2K93_RS14820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2K93_RS14825	COG2226	methyltransferase
E2K93_RS14830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E2K93_RS14835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E2K93_RS14840	COG0632	four-way junction helicase activity
E2K93_RS14845	COG2255	four-way junction helicase activity
E2K93_RS14860	COG0824	Thioesterase
E2K93_RS14865	COG0811	peptide transport
E2K93_RS14880	COG0823	Involved in the tonB-independent uptake of proteins
E2K93_RS14885	COG2885	chlorophyll binding
E2K93_RS14925	COG0705	Rhomboid family
E2K93_RS14925	COG0457	Tetratricopeptide repeat
E2K93_RS14935	COG0405	Gamma-glutamyltransferase
E2K93_RS14945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2K93_RS15015	COG0328	RNA-DNA hybrid ribonuclease activity
E2K93_RS15020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E2K93_RS15060	COG1960	acyl-CoA dehydrogenase activity
E2K93_RS15065	COG0121	glutamine amidotransferase
E2K93_RS15075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E2K93_RS15080	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E2K93_RS15105	COG1393	Belongs to the ArsC family
E2K93_RS15110	COG4783	chaperone-mediated protein folding
E2K93_RS15125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E2K93_RS15130	COG2716	regulation of RNA biosynthetic process
E2K93_RS15135	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E2K93_RS15170	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E2K93_RS15175	COG1053	succinate dehydrogenase
E2K93_RS15185	COG0567	Dehydrogenase, E1 component
E2K93_RS15190	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2K93_RS15215	COG2201	protein-glutamate methylesterase activity
E2K93_RS15220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K93_RS15220	COG1116	anion transmembrane transporter activity
E2K93_RS15225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2K93_RS15230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2K93_RS15235	COG1116	anion transmembrane transporter activity
E2K93_RS15245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2K93_RS15245	COG2146	nitrite reductase [NAD(P)H] activity
E2K93_RS15250	COG2146	nitrite reductase [NAD(P)H] activity
E2K93_RS15255	COG0243	molybdopterin cofactor binding
E2K93_RS15260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2K93_RS15260	COG1648	precorrin-2 dehydrogenase activity
E2K93_RS15265	COG0045	succinate-CoA ligase (ADP-forming) activity
E2K93_RS15270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E2K93_RS15280	COG1505	serine-type exopeptidase activity
E2K93_RS15310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2K93_RS15315	COG0735	belongs to the Fur family
E2K93_RS15320	COG0716	FMN binding
E2K93_RS15335	COG0596	Alpha beta hydrolase
E2K93_RS15345	COG0033	Phosphoglucomutase
E2K93_RS15350	COG2988	succinylglutamate desuccinylase activity
E2K93_RS15355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E2K93_RS15360	COG0022	dehydrogenase e1 component
E2K93_RS15385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2K93_RS15385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2K93_RS15395	COG0717	Belongs to the dCTP deaminase family
E2K93_RS15430	COG0531	amino acid
E2K93_RS15435	COG1309	transcriptional regulator
E2K93_RS15450	COG0248	Ppx GppA phosphatase
E2K93_RS15455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E2K93_RS15480	COG0440	acetolactate synthase activity
E2K93_RS15485	COG0028	Belongs to the TPP enzyme family
E2K93_RS15490	COG3724	N-succinylarginine dihydrolase activity
E2K93_RS15495	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E2K93_RS15500	COG4206	TonB-dependent receptor
E2K93_RS15510	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E2K93_RS15515	COG1492	cobalamin metabolic process
E2K93_RS15520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2K93_RS15525	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E2K93_RS15530	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E2K93_RS15535	COG0436	Aminotransferase
E2K93_RS15575	COG0442	prolyl-tRNA aminoacylation
E2K93_RS15585	COG1054	Belongs to the UPF0176 family
E2K93_RS15590	COG1720	tRNA m6t6A37 methyltransferase activity
E2K93_RS15615	COG4681	YaeQ
E2K93_RS15620	COG0346	lactoylglutathione lyase activity
E2K93_RS15650	COG0823	Involved in the tonB-independent uptake of proteins
E2K93_RS15650	COG1506	peptidase
E2K93_RS15650	COG4946	Tricorn protease homolog
E2K93_RS15690	COG3119	arylsulfatase activity
E2K93_RS15695	COG1858	cytochrome C peroxidase
E2K93_RS15700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E2K93_RS15705	COG4660	Part of a membrane complex involved in electron transport
E2K93_RS15710	COG4659	FMN binding
E2K93_RS15715	COG4658	electron transport chain
E2K93_RS15720	COG4656	Part of a membrane complex involved in electron transport
E2K93_RS15725	COG2878	Part of a membrane complex involved in electron transport
E2K93_RS15730	COG4657	Part of a membrane complex involved in electron transport
E2K93_RS15735	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E2K93_RS15740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E2K93_RS15745	COG4536	flavin adenine dinucleotide binding
E2K93_RS15755	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E2K93_RS15775	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E2K93_RS15780	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
E2K93_RS15785	COG1196	nuclear chromosome segregation
E2K93_RS15795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E2K93_RS15805	COG0702	epimerase
E2K93_RS15820	COG0583	DNA-binding transcription factor activity
E2K93_RS15850	COG2040	homocysteine
E2K93_RS15860	COG1607	acyl-coa hydrolase
E2K93_RS15870	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E2K93_RS15875	COG3273	potassium ion transport
E2K93_RS15875	COG0471	metal ion transport
E2K93_RS15880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E2K93_RS15890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2K93_RS15915	COG1301	dicarboxylic acid transport
E2K93_RS15925	COG2311	Membrane
E2K93_RS15950	COG0123	including yeast histone deacetylase and acetoin utilization protein
E2K93_RS15960	COG0513	Belongs to the DEAD box helicase family
E2K93_RS15990	COG1404	Belongs to the peptidase S8 family
E2K93_RS15995	COG5002	protein histidine kinase activity
E2K93_RS15995	COG2205	protein histidine kinase activity
E2K93_RS15995	COG0784	Response regulator, receiver
E2K93_RS16005	COG2204	response regulator
E2K93_RS16025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E2K93_RS16030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E2K93_RS16035	COG0539	negative regulation of cytoplasmic translation
E2K93_RS16040	COG0776	regulation of translation
E2K93_RS16050	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E2K93_RS16055	COG0284	orotidine-5'-phosphate decarboxylase activity
E2K93_RS16060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E2K93_RS16065	COG1555	photosystem II stabilization
E2K93_RS16070	COG1530	ribonuclease E activity
E2K93_RS16075	COG0564	pseudouridine synthase activity
E2K93_RS16095	COG1399	metal-binding, possibly nucleic acid-binding protein
E2K93_RS16100	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E2K93_RS16105	COG0416	fatty acid biosynthetic process
E2K93_RS16110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2K93_RS16125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2K93_RS16130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2K93_RS16135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E2K93_RS16140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E2K93_RS16145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E2K93_RS16160	COG0084	hydrolase, TatD family'
E2K93_RS16165	COG2715	membrane protein required for spore maturation
E2K93_RS16200	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E2K93_RS16205	COG0372	Belongs to the citrate synthase family
E2K93_RS16235	COG1956	GAF domain-containing protein
E2K93_RS16245	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E2K93_RS16250	COG0793	Belongs to the peptidase S41A family
E2K93_RS16255	COG1757	Na H antiporter
E2K93_RS16260	COG0308	aminopeptidase N
E2K93_RS16285	COG2902	Dehydrogenase
E2K93_RS16290	COG0167	dihydroorotate dehydrogenase activity
E2K93_RS16295	COG0564	pseudouridine synthase activity
E2K93_RS16310	COG0367	asparagine synthase
E2K93_RS16320	COG4555	ABC transporter
E2K93_RS16325	COG1668	transmembrane transport
E2K93_RS16330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E2K93_RS16335	COG0072	phenylalanine-tRNA ligase activity
E2K93_RS16335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2K93_RS16340	COG0776	regulation of translation
E2K93_RS16350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E2K93_RS16350	COG0674	pyruvate-flavodoxin oxidoreductase activity
E2K93_RS16355	COG0493	'glutamate synthase
E2K93_RS16370	COG1280	lysine exporter protein (LysE YggA)
E2K93_RS16395	COG2252	PERMEase
E2K93_RS16405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2K93_RS16420	COG2217	Heavy metal translocating P-type atpase
E2K93_RS16445	COG3278	Belongs to the heme-copper respiratory oxidase family
E2K93_RS16460	COG1280	lysine exporter protein (LysE YggA)
E2K93_RS16475	COG0625	glutathione transferase activity
E2K93_RS16495	COG1028	Short-chain dehydrogenase reductase Sdr
E2K93_RS16500	COG0183	Belongs to the thiolase family
E2K93_RS16520	COG0446	pyridine nucleotide-disulphide oxidoreductase
E2K93_RS16520	COG1902	pentaerythritol trinitrate reductase activity
E2K93_RS16525	COG2272	Belongs to the type-B carboxylesterase lipase family
E2K93_RS16530	COG2211	Major facilitator Superfamily
E2K93_RS16535	COG4771	TonB-dependent receptor
E2K93_RS16550	COG1454	alcohol dehydrogenase
E2K93_RS16555	COG0824	Thioesterase
E2K93_RS16590	COG2130	NADP-dependent
E2K93_RS16595	COG1960	acyl-CoA dehydrogenase activity
E2K93_RS16600	COG1960	acyl-CoA dehydrogenase activity
E2K93_RS16610	COG2311	Membrane
E2K93_RS16635	COG0534	Mate efflux family protein
E2K93_RS16640	COG0556	nucleotide-excision repair
E2K93_RS16680	COG4106	trans-aconitate 2-methyltransferase activity
E2K93_RS16690	COG5001	Diguanylate cyclase
E2K93_RS16690	COG1716	ATPase activity
E2K93_RS16710	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E2K93_RS16715	COG0602	queuosine metabolic process
E2K93_RS16720	COG0730	response to heat
E2K93_RS16730	COG1199	ATP-dependent helicase activity
E2K93_RS16735	COG0417	DNA replication proofreading
E2K93_RS16740	COG0626	cystathionine gamma-synthase activity
E2K93_RS16745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2K93_RS16750	COG0789	Transcriptional regulator
E2K93_RS16765	COG1230	cation diffusion facilitator family transporter
E2K93_RS16790	COG1785	Belongs to the alkaline phosphatase family
E2K93_RS16795	COG1435	thymidine kinase activity
E2K93_RS16800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E2K93_RS16805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E2K93_RS16810	COG0572	uridine kinase
E2K93_RS16820	COG0813	purine-nucleoside phosphorylase activity
E2K93_RS16830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E2K93_RS16860	COG0587	DNA-directed DNA polymerase activity
E2K93_RS16885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E2K93_RS16895	COG0348	domain, Protein
E2K93_RS16900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2K93_RS16910	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E2K93_RS16915	COG0574	Belongs to the PEP-utilizing enzyme family
E2K93_RS16915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E2K93_RS16920	COG0247	lactate metabolic process
E2K93_RS16920	COG0277	FAD linked oxidase domain protein
E2K93_RS16930	COG0604	alcohol dehydrogenase
E2K93_RS16935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E2K93_RS16950	COG2850	peptidyl-arginine hydroxylation
E2K93_RS16955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E2K93_RS16960	COG2915	High frequency lysogenization protein hflD homolog
E2K93_RS16965	COG0482	sulfurtransferase activity
E2K93_RS16975	COG1187	pseudouridine synthase activity
E2K93_RS16985	COG1278	Cold shock
E2K93_RS16990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E2K93_RS16995	COG0542	response to heat
E2K93_RS17010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E2K93_RS17015	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E2K93_RS17025	COG0492	ferredoxin-NADP+ reductase activity
E2K93_RS17030	COG0686	Belongs to the AlaDH PNT family
E2K93_RS17040	COG1674	ftsk spoiiie
E2K93_RS17040	COG0531	amino acid
E2K93_RS17045	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E2K93_RS17050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E2K93_RS17055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E2K93_RS17060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E2K93_RS17085	COG2920	part of a sulfur-relay system
E2K93_RS17095	COG2923	Belongs to the DsrF TusC family
E2K93_RS17100	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E2K93_RS17105	COG0670	Belongs to the BI1 family
E2K93_RS17110	COG0519	Catalyzes the synthesis of GMP from XMP
E2K93_RS17130	COG4282	regulation of fungal-type cell wall biogenesis
E2K93_RS17215	COG5507	3-demethylubiquinone-9 3-methyltransferase
E2K93_RS17220	COG0454	-acetyltransferase
E2K93_RS17235	COG2234	aminopeptidase activity
E2K93_RS17260	COG2995	paraquat-inducible protein a
E2K93_RS17265	COG3008	intermembrane lipid transfer
E2K93_RS17295	COG3081	Nucleoid-associated protein
E2K93_RS17300	COG3082	Protein of unknown function (DUF1414)
E2K93_RS17345	COG2819	hydrolase of the alpha beta superfamily
E2K93_RS17355	COG2067	long-chain fatty acid transport protein
E2K93_RS17380	COG2304	oxidoreductase activity
E2K93_RS17400	COG0714	Associated with various cellular activities
E2K93_RS17410	COG0786	glutamate:sodium symporter activity
E2K93_RS17415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E2K93_RS17420	COG2226	methyltransferase
E2K93_RS17420	COG1073	alpha beta
E2K93_RS17425	COG0156	8-amino-7-oxononanoate synthase activity
E2K93_RS17430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E2K93_RS17435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2K93_RS17440	COG0017	Asparaginyl-tRNA synthetase
E2K93_RS17445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2K93_RS17450	COG1136	(ABC) transporter
E2K93_RS17450	COG0577	efflux transmembrane transporter activity
E2K93_RS17455	COG0577	efflux transmembrane transporter activity
E2K93_RS17455	COG1136	(ABC) transporter
E2K93_RS17485	COG0778	Nitroreductase
E2K93_RS17495	COG0616	signal peptide processing
E2K93_RS17515	COG3139	Protein of unknown function (DUF1315)
E2K93_RS17525	COG1115	amino acid carrier protein
E2K93_RS17530	COG2866	Carboxypeptidase
E2K93_RS17545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2K93_RS17550	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E2K93_RS17565	COG3119	arylsulfatase activity
E2K93_RS17575	COG0800	Aldolase
E2K93_RS17585	COG0129	dihydroxy-acid dehydratase activity
E2K93_RS17590	COG0363	glucosamine-6-phosphate deaminase activity
E2K93_RS17595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E2K93_RS17600	COG1737	Transcriptional regulator
E2K93_RS17605	COG0469	pyruvate kinase activity
E2K93_RS17610	COG0205	6-phosphofructokinase activity
E2K93_RS17615	COG3279	Response regulator of the LytR AlgR family
E2K93_RS17620	COG3275	phosphorelay sensor kinase activity
E2K93_RS17630	COG3201	nicotinamide mononucleotide transporter
E2K93_RS17640	COG4773	Receptor
E2K93_RS17645	COG0537	adenosine 5'-monophosphoramidase activity