locus-tag	class	description
LP316_RS00030	COG0023	Translation Initiation Factor
LP316_RS00035	COG0745	RESPONSE REGULATOR receiver
LP316_RS00040	COG3119	arylsulfatase activity
LP316_RS00050	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LP316_RS00085	COG1183	phosphatidylcholine synthase activity
LP316_RS00095	COG0542	response to heat
LP316_RS00105	COG0564	pseudouridine synthase activity
LP316_RS00110	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LP316_RS00120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LP316_RS00125	COG4969	Belongs to the N-Me-Phe pilin family
LP316_RS00160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LP316_RS00165	COG1047	Peptidyl-prolyl cis-trans
LP316_RS00175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LP316_RS00180	COG0196	riboflavin kinase activity
LP316_RS00185	COG0728	peptidoglycan biosynthetic process
LP316_RS00190	COG0268	Binds directly to 16S ribosomal RNA
LP316_RS00200	COG3118	belongs to the thioredoxin family
LP316_RS00210	COG1968	undecaprenyl-diphosphatase activity
LP316_RS00215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LP316_RS00220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LP316_RS00225	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LP316_RS00230	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LP316_RS00235	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LP316_RS00240	COG1610	YqeY-like protein
LP316_RS00260	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LP316_RS00265	COG0583	DNA-binding transcription factor activity
LP316_RS00285	COG1238	metal cluster binding
LP316_RS00290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LP316_RS00295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LP316_RS00305	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LP316_RS00310	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LP316_RS00315	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LP316_RS00325	COG0583	DNA-binding transcription factor activity
LP316_RS00335	COG0656	L-ascorbic acid biosynthetic process
LP316_RS00340	COG4771	TonB-dependent receptor
LP316_RS00350	COG0596	Alpha beta hydrolase
LP316_RS00365	COG2130	NADP-dependent
LP316_RS00375	COG0318	PFAM AMP-dependent synthetase and ligase
LP316_RS00380	COG1028	Short-chain dehydrogenase reductase Sdr
LP316_RS00390	COG1960	acyl-CoA dehydrogenase activity
LP316_RS00395	COG1028	Short-chain dehydrogenase reductase Sdr
LP316_RS00415	COG1028	Short-chain dehydrogenase reductase Sdr
LP316_RS00435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LP316_RS00450	COG0625	glutathione transferase activity
LP316_RS00460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LP316_RS00470	COG3608	succinylglutamate desuccinylase aspartoacylase
LP316_RS00490	COG1429	ligase activity, forming nitrogen-metal bonds
LP316_RS00525	COG1266	CAAX protease self-immunity
LP316_RS00575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LP316_RS00605	COG2200	EAL domain
LP316_RS00630	COG0795	lipopolysaccharide-transporting ATPase activity
LP316_RS00635	COG0795	lipopolysaccharide-transporting ATPase activity
LP316_RS00640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LP316_RS00650	COG0525	valine-tRNA ligase activity
LP316_RS00655	COG1278	Cold shock
LP316_RS00660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LP316_RS00695	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LP316_RS00700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LP316_RS00705	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LP316_RS00710	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LP316_RS00725	COG1049	propionate catabolic process, 2-methylcitrate cycle
LP316_RS00735	COG4946	Tricorn protease homolog
LP316_RS00735	COG1506	peptidase
LP316_RS00735	COG0823	Involved in the tonB-independent uptake of proteins
LP316_RS00740	COG4771	TonB-dependent receptor
LP316_RS00745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LP316_RS00750	COG0508	dehydrogenase complex catalyzes the overall conversion of
LP316_RS00755	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LP316_RS00760	COG2186	Transcriptional regulator
LP316_RS00770	COG3023	N-Acetylmuramoyl-L-alanine amidase
LP316_RS00780	COG0157	Belongs to the NadC ModD family
LP316_RS00790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LP316_RS00795	COG1459	type II secretion system
LP316_RS00800	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LP316_RS00810	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LP316_RS00820	COG0494	nUDIX hydrolase
LP316_RS00825	COG0653	protein targeting
LP316_RS00830	COG0739	heme binding
LP316_RS00840	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LP316_RS00845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LP316_RS00850	COG0849	cell division
LP316_RS00855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LP316_RS00865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LP316_RS00875	COG0772	Belongs to the SEDS family
LP316_RS00885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LP316_RS00890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LP316_RS00895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LP316_RS00900	COG0768	penicillin binding
LP316_RS00905	COG3116	cell division
LP316_RS00910	COG0275	rRNA processing
LP316_RS00915	COG2001	Belongs to the MraZ family
LP316_RS00925	COG3842	ATPase activity
LP316_RS00935	COG1840	ABC-type Fe3 transport system, periplasmic component
LP316_RS00955	COG0022	dehydrogenase e1 component
LP316_RS00960	COG1960	acyl-CoA dehydrogenase activity
LP316_RS00965	COG0583	DNA-binding transcription factor activity
LP316_RS00985	COG1024	Enoyl-CoA hydratase
LP316_RS01000	COG1842	Phage shock protein A
LP316_RS01020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LP316_RS01025	COG0735	belongs to the Fur family
LP316_RS01040	COG0432	Pfam Uncharacterised protein family UPF0047
LP316_RS01045	COG4206	TonB-dependent receptor
LP316_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LP316_RS01055	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LP316_RS01060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LP316_RS01065	COG1120	ATPase activity
LP316_RS01070	COG0668	transmembrane transport
LP316_RS01090	COG4152	abc transporter atp-binding protein
LP316_RS01140	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LP316_RS01170	COG3292	Two component regulator propeller
LP316_RS01170	COG0745	RESPONSE REGULATOR receiver
LP316_RS01170	COG2205	protein histidine kinase activity
LP316_RS01180	COG1404	Belongs to the peptidase S8 family
LP316_RS01195	COG3590	peptidase
LP316_RS01205	COG1301	dicarboxylic acid transport
LP316_RS01210	COG1283	sodium-dependent phosphate transmembrane transporter activity
LP316_RS01215	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LP316_RS01220	COG1611	Belongs to the LOG family
LP316_RS01225	COG1846	Transcriptional regulator
LP316_RS01235	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LP316_RS01265	COG4585	Histidine kinase
LP316_RS01270	COG2197	response regulator
LP316_RS01290	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LP316_RS01295	COG2823	Periplasmic or secreted lipoprotein
LP316_RS01310	COG0175	sulfate reduction
LP316_RS01315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LP316_RS01335	COG0625	glutathione transferase activity
LP316_RS01340	COG3119	arylsulfatase activity
LP316_RS01345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LP316_RS01350	COG0305	Participates in initiation and elongation during chromosome replication
LP316_RS01370	COG0254	rRNA binding
LP316_RS01380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LP316_RS01385	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LP316_RS01390	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LP316_RS01395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LP316_RS01410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LP316_RS01435	COG0330	HflC and HflK could
LP316_RS01440	COG0330	HflC and HflK could
LP316_RS01450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LP316_RS01460	COG0456	acetyltransferase
LP316_RS01470	COG1490	D-aminoacyl-tRNA deacylase activity
LP316_RS01480	COG1295	ribonuclease BN
LP316_RS01505	COG1217	gtp-binding protein TYPA
LP316_RS01510	COG0174	glutamine synthetase
LP316_RS01520	COG3852	Histidine kinase
LP316_RS01535	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LP316_RS01570	COG0724	RNA recognition motif
LP316_RS01575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LP316_RS01590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LP316_RS01605	COG5001	Diguanylate cyclase
LP316_RS01635	COG2996	Protein conserved in bacteria
LP316_RS01640	COG4771	TonB-dependent receptor
LP316_RS01665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LP316_RS01665	COG4191	Histidine kinase
LP316_RS01670	COG0745	RESPONSE REGULATOR receiver
LP316_RS01680	COG1469	GTP cyclohydrolase I activity
LP316_RS01685	COG0067	glutamate synthase
LP316_RS01685	COG0070	glutamate synthase
LP316_RS01685	COG0069	glutamate synthase activity
LP316_RS01690	COG0493	'glutamate synthase
LP316_RS01695	COG1028	Short-chain dehydrogenase reductase Sdr
LP316_RS01700	COG0183	Belongs to the thiolase family
LP316_RS01710	COG1028	Short-chain dehydrogenase reductase Sdr
LP316_RS01730	COG2205	protein histidine kinase activity
LP316_RS01750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LP316_RS01760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LP316_RS01780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LP316_RS01785	COG4942	peptidase
LP316_RS01825	COG0446	pyridine nucleotide-disulphide oxidoreductase
LP316_RS01825	COG1902	pentaerythritol trinitrate reductase activity
LP316_RS01835	COG2814	Major facilitator Superfamily
LP316_RS01840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LP316_RS01865	COG4946	Tricorn protease homolog
LP316_RS01865	COG1506	peptidase
LP316_RS01865	COG0823	Involved in the tonB-independent uptake of proteins
LP316_RS01870	COG0163	prenyltransferase activity
LP316_RS01875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LP316_RS01880	COG0633	Ferredoxin
LP316_RS01880	COG3217	Mosc domain protein beta barrel domain protein
LP316_RS01895	COG1984	allophanate hydrolase subunit 2
LP316_RS01905	COG0512	Glutamine amidotransferase of anthranilate synthase
LP316_RS01915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LP316_RS01925	COG1012	belongs to the aldehyde dehydrogenase family
LP316_RS01940	COG1765	OsmC-like protein
LP316_RS01945	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LP316_RS01950	COG3954	Phosphoribulokinase
LP316_RS01955	COG0203	ribosomal protein L17
LP316_RS01960	COG0202	RNA polymerase activity
LP316_RS01965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LP316_RS01970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LP316_RS01975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LP316_RS01985	COG0201	protein transport
LP316_RS01990	COG0200	Binds to the 23S rRNA
LP316_RS01995	COG1841	ribosomal large subunit assembly
LP316_RS02000	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LP316_RS02005	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LP316_RS02010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LP316_RS02015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LP316_RS02025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LP316_RS02030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LP316_RS02040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LP316_RS02045	COG0255	Belongs to the universal ribosomal protein uL29 family
LP316_RS02050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LP316_RS02055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LP316_RS02060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LP316_RS02065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LP316_RS02070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LP316_RS02075	COG0089	rRNA binding
LP316_RS02080	COG0088	Forms part of the polypeptide exit tunnel
LP316_RS02085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LP316_RS02090	COG0051	transcription antitermination factor activity, RNA binding
LP316_RS02095	COG2205	protein histidine kinase activity
LP316_RS02100	COG0745	RESPONSE REGULATOR receiver
LP316_RS02145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LP316_RS02155	COG1187	pseudouridine synthase activity
LP316_RS02160	COG4771	TonB-dependent receptor
LP316_RS02170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LP316_RS02175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LP316_RS02180	COG0049	tRNA binding
LP316_RS02185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LP316_RS02190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LP316_RS02195	COG0085	RNA polymerase activity
LP316_RS02200	COG0222	ribosome binding
LP316_RS02205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LP316_RS02210	COG0081	regulation of translation
LP316_RS02215	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LP316_RS02220	COG0250	Participates in transcription elongation, termination and antitermination
LP316_RS02235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LP316_RS02275	COG0489	protein tyrosine kinase activity
LP316_RS02275	COG3206	protein involved in exopolysaccharide biosynthesis
LP316_RS02310	COG0151	Belongs to the GarS family
LP316_RS02320	COG0138	bifunctional purine biosynthesis protein purh
LP316_RS02325	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LP316_RS02335	COG2264	protein methyltransferase activity
LP316_RS02340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LP316_RS02345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LP316_RS02345	COG1648	precorrin-2 dehydrogenase activity
LP316_RS02355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LP316_RS02365	COG0180	Tryptophanyl-tRNA synthetase
LP316_RS02370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LP316_RS02385	COG0583	DNA-binding transcription factor activity
LP316_RS02405	COG2184	nucleotidyltransferase activity
LP316_RS02430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LP316_RS02475	COG0402	S-adenosylhomocysteine deaminase activity
LP316_RS02480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LP316_RS02485	COG0243	molybdopterin cofactor binding
LP316_RS02500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LP316_RS02505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LP316_RS02525	COG0629	single-stranded DNA binding
LP316_RS02540	COG2268	Band 7 protein
LP316_RS02555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LP316_RS02560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LP316_RS02565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LP316_RS02595	COG1612	heme a metabolic process
LP316_RS02600	COG0109	protoheme IX farnesyltransferase activity
LP316_RS02615	COG0534	Mate efflux family protein
LP316_RS02620	COG0316	Belongs to the HesB IscA family
LP316_RS02620	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LP316_RS02630	COG1040	competence protein
LP316_RS02635	COG0596	Alpha beta hydrolase
LP316_RS02655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LP316_RS02680	COG0577	efflux transmembrane transporter activity
LP316_RS02680	COG1136	(ABC) transporter
LP316_RS02685	COG0577	efflux transmembrane transporter activity
LP316_RS02700	COG1561	YicC-like family, N-terminal region
LP316_RS02760	COG3550	peptidyl-serine autophosphorylation
LP316_RS02770	COG1506	peptidase
LP316_RS02780	COG2183	response to ionizing radiation
LP316_RS02785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LP316_RS02790	COG0513	Belongs to the DEAD box helicase family
LP316_RS02810	COG1448	Aminotransferase
LP316_RS02815	COG0194	GDP metabolic process
LP316_RS02820	COG1758	RNA polymerase activity
LP316_RS02825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LP316_RS02835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LP316_RS02840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LP316_RS02845	COG2226	methyltransferase
LP316_RS02855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LP316_RS02900	COG0129	dihydroxy-acid dehydratase activity
LP316_RS02905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LP316_RS02920	COG0606	chelatase, subunit chli
LP316_RS02930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LP316_RS02935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LP316_RS02940	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LP316_RS02945	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LP316_RS02950	COG1166	arginine decarboxylase activity
LP316_RS02955	COG0204	Acyl-transferase
LP316_RS02960	COG0668	transmembrane transport
LP316_RS02965	COG1946	Acyl-CoA thioesterase
LP316_RS03000	COG1683	Conserved Protein
LP316_RS03015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LP316_RS03030	COG2962	Rard protein
LP316_RS03040	COG0210	DNA helicase
LP316_RS03055	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LP316_RS03060	COG0019	diaminopimelate decarboxylase activity
LP316_RS03065	COG1965	Belongs to the frataxin family
LP316_RS03070	COG0181	hydroxymethylbilane synthase activity
LP316_RS03080	COG2959	enzyme of heme biosynthesis
LP316_RS03115	COG3118	belongs to the thioredoxin family
LP316_RS03120	COG0513	Belongs to the DEAD box helicase family
LP316_RS03125	COG0248	Ppx GppA phosphatase
LP316_RS03140	COG0084	hydrolase, TatD family'
LP316_RS03150	COG0805	protein transport
LP316_RS03155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LP316_RS03160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LP316_RS03200	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LP316_RS03205	COG2177	Part of the ABC transporter FtsEX involved in
LP316_RS03210	COG2884	Cell division ATP-binding protein ftsE
LP316_RS03215	COG0552	protein localization to endoplasmic reticulum
LP316_RS03220	COG0742	ribosomal rna small subunit methyltransferase
LP316_RS03375	COG1566	PFAM secretion protein HlyD family protein
LP316_RS03380	COG0628	permease
LP316_RS03415	COG3064	Membrane
LP316_RS03420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LP316_RS03425	COG1349	DNA-binding transcription factor activity
LP316_RS03430	COG0741	lytic transglycosylase activity
LP316_RS03435	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LP316_RS03440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LP316_RS03445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LP316_RS03450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LP316_RS03455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LP316_RS03460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LP316_RS03465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LP316_RS03485	COG1475	DNA binding
LP316_RS03490	COG1192	Involved in chromosome partitioning
LP316_RS03495	COG0357	Ribosomal RNA small subunit methyltransferase G
LP316_RS03500	COG0445	tRNA wobble uridine modification
LP316_RS03505	COG0716	FMN binding
LP316_RS03510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LP316_RS03515	COG0706	membrane insertase activity
LP316_RS03520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LP316_RS03530	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LP316_RS03535	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LP316_RS03550	COG0187	DNA topoisomerase II activity
LP316_RS03555	COG0752	glycyl-tRNA synthetase alpha subunit
LP316_RS03560	COG0751	glycine-tRNA ligase activity
LP316_RS03565	COG0425	Belongs to the sulfur carrier protein TusA family
LP316_RS03580	COG0006	proline dipeptidase activity
LP316_RS03585	COG1739	Uncharacterized protein family UPF0029
LP316_RS03590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LP316_RS03595	COG0569	domain protein
LP316_RS03600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LP316_RS03600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LP316_RS03610	COG0242	peptide deformylase activity
LP316_RS03615	COG1652	LysM domain
LP316_RS03620	COG0758	DNA mediated transformation
LP316_RS03625	COG2922	Belongs to the Smg family
LP316_RS03630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LP316_RS03640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LP316_RS03645	COG0318	PFAM AMP-dependent synthetase and ligase
LP316_RS03660	COG3047	cAMP biosynthetic process
LP316_RS03675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LP316_RS03710	COG0745	RESPONSE REGULATOR receiver
LP316_RS03715	COG1960	acyl-CoA dehydrogenase activity
LP316_RS03720	COG1505	serine-type exopeptidase activity
LP316_RS03725	COG3706	GGDEF domain
LP316_RS03730	COG2081	HI0933 family
LP316_RS03735	COG1528	Iron-storage protein
LP316_RS03740	COG0678	peroxiredoxin activity
LP316_RS03750	COG0742	ribosomal rna small subunit methyltransferase
LP316_RS03770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LP316_RS03775	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LP316_RS03775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LP316_RS03790	COG1595	DNA-templated transcription, initiation
LP316_RS03820	COG4555	ABC transporter
LP316_RS03835	COG0596	Alpha beta hydrolase
LP316_RS03845	COG1272	protein, Hemolysin III
LP316_RS03855	COG2059	Chromate
LP316_RS03860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LP316_RS03880	COG2995	paraquat-inducible protein a
LP316_RS03885	COG3008	intermembrane lipid transfer
LP316_RS03890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LP316_RS03895	COG0840	transmembrane signaling receptor activity
LP316_RS03925	COG2195	Cleaves the N-terminal amino acid of tripeptides
LP316_RS03930	COG1309	transcriptional regulator
LP316_RS03935	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LP316_RS03940	COG2003	Belongs to the UPF0758 family
LP316_RS03960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LP316_RS03965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LP316_RS03975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LP316_RS03980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LP316_RS03995	COG3642	lipopolysaccharide core region biosynthetic process
LP316_RS04005	COG1519	Transferase
LP316_RS04010	COG0156	8-amino-7-oxononanoate synthase activity
LP316_RS04015	COG1063	alcohol dehydrogenase
LP316_RS04020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LP316_RS04035	COG0534	Mate efflux family protein
LP316_RS04045	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LP316_RS04055	COG2937	Belongs to the GPAT DAPAT family
LP316_RS04070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LP316_RS04075	COG3290	protein histidine kinase activity
LP316_RS04080	COG2204	response regulator
LP316_RS04090	COG3409	Peptidoglycan-binding domain 1 protein
LP316_RS04090	COG3267	Type II secretory pathway component ExeA
LP316_RS04100	COG0489	protein tyrosine kinase activity
LP316_RS04110	COG1596	polysaccharide export
LP316_RS04115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LP316_RS04120	COG0673	inositol 2-dehydrogenase activity
LP316_RS04140	COG0438	transferase activity, transferring glycosyl groups
LP316_RS04155	COG0726	polysaccharide deacetylase
LP316_RS04170	COG1045	serine acetyltransferase
LP316_RS04220	COG2861	carbohydrate metabolic process
LP316_RS04225	COG4942	peptidase
LP316_RS04230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LP316_RS04235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LP316_RS04240	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LP316_RS04245	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LP316_RS04250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LP316_RS04255	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LP316_RS04260	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LP316_RS04265	COG2267	carboxylic ester hydrolase activity
LP316_RS04285	COG0688	phosphatidylethanolamine metabolic process
LP316_RS04290	COG1162	GTPase activity
LP316_RS04295	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LP316_RS04315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LP316_RS04315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LP316_RS04320	COG0802	atpase or kinase
LP316_RS04325	COG0860	N-Acetylmuramoyl-L-alanine amidase
LP316_RS04335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LP316_RS04340	COG1923	regulation of RNA biosynthetic process
LP316_RS04345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LP316_RS04350	COG0330	HflC and HflK could
LP316_RS04355	COG0330	HflC and HflK could
LP316_RS04365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LP316_RS04370	COG0281	malic enzyme
LP316_RS04375	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
LP316_RS04380	COG0626	cystathionine gamma-synthase activity
LP316_RS04385	COG0527	aspartate kinase activity
LP316_RS04385	COG0460	homoserine dehydrogenase
LP316_RS04395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LP316_RS04400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LP316_RS04405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LP316_RS04410	COG0137	argininosuccinate synthase activity
LP316_RS04415	COG0165	Argininosuccinate lyase
LP316_RS04415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LP316_RS04420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LP316_RS04420	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LP316_RS04430	COG1215	transferase activity, transferring glycosyl groups
LP316_RS04445	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LP316_RS04475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LP316_RS04480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LP316_RS04490	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LP316_RS04515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LP316_RS04520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LP316_RS04525	COG1045	serine acetyltransferase
LP316_RS04535	COG0438	transferase activity, transferring glycosyl groups
LP316_RS04550	COG0438	transferase activity, transferring glycosyl groups
LP316_RS04550	COG0297	glycogen (starch) synthase activity
LP316_RS04555	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LP316_RS04595	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LP316_RS04600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LP316_RS04610	COG3031	protein transport across the cell outer membrane
LP316_RS04620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LP316_RS04625	COG1459	type II secretion system
LP316_RS04630	COG2165	general secretion pathway protein
LP316_RS04640	COG2165	general secretion pathway protein
LP316_RS04645	COG4795	General secretion pathway protein
LP316_RS04650	COG3156	type II secretion system protein K
LP316_RS04660	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LP316_RS04670	COG1011	Hydrolase
LP316_RS04675	COG0494	nUDIX hydrolase
LP316_RS04680	COG1218	3'(2'),5'-bisphosphate nucleotidase
LP316_RS04695	COG0429	hydrolase of the alpha beta-hydrolase fold
LP316_RS04700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LP316_RS04710	COG0488	(ABC) transporter
LP316_RS04720	COG2900	Belongs to the SlyX family
LP316_RS04730	COG0545	Peptidyl-prolyl cis-trans isomerase
LP316_RS04745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LP316_RS04750	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LP316_RS04750	COG0506	proline dehydrogenase activity
LP316_RS04750	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LP316_RS04770	COG0733	neurotransmitter:sodium symporter activity
LP316_RS04775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LP316_RS04780	COG1280	lysine exporter protein (LysE YggA)
LP316_RS04785	COG1793	dna ligase
LP316_RS04805	COG2827	Endonuclease containing a URI domain
LP316_RS04820	COG0347	Belongs to the P(II) protein family
LP316_RS04825	COG0004	ammonium transporteR
LP316_RS04830	COG2837	iron assimilation
LP316_RS04835	COG1438	arginine binding
LP316_RS04840	COG0039	L-malate dehydrogenase activity
LP316_RS04850	COG0142	geranyltranstransferase activity
LP316_RS04855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LP316_RS04865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LP316_RS04890	COG2967	ApaG domain
LP316_RS04895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LP316_RS04900	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LP316_RS04905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LP316_RS04910	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LP316_RS04920	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LP316_RS04925	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LP316_RS04950	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LP316_RS04960	COG0069	glutamate synthase activity
LP316_RS04970	COG5002	protein histidine kinase activity
LP316_RS04970	COG2205	protein histidine kinase activity
LP316_RS04970	COG0784	Response regulator, receiver
LP316_RS04980	COG1960	acyl-CoA dehydrogenase activity
LP316_RS04990	COG1024	Enoyl-CoA hydratase
LP316_RS04990	COG1250	3-hydroxyacyl-CoA dehydrogenase
LP316_RS04995	COG0183	Belongs to the thiolase family
LP316_RS05020	COG1227	inorganic diphosphatase activity
LP316_RS05025	COG1294	oxidase, subunit
LP316_RS05030	COG1271	oxidase subunit
LP316_RS05040	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LP316_RS05050	COG0697	spore germination
LP316_RS05055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LP316_RS05060	COG2814	Major facilitator Superfamily
LP316_RS05070	COG0439	Biotin carboxylase
LP316_RS05075	COG0511	ligase activity, forming carbon-carbon bonds
LP316_RS05080	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LP316_RS05105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LP316_RS05110	COG4232	protein-disulfide reductase activity
LP316_RS05115	COG1324	tolerance protein
LP316_RS05125	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LP316_RS05140	COG4946	Tricorn protease homolog
LP316_RS05140	COG0823	Involved in the tonB-independent uptake of proteins
LP316_RS05140	COG1506	peptidase
LP316_RS05160	COG0668	transmembrane transport
LP316_RS05170	COG1509	lysine 2,3-aminomutase activity
LP316_RS05175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LP316_RS05180	COG1131	(ABC) transporter
LP316_RS05185	COG0842	Transport permease protein
LP316_RS05190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LP316_RS05195	COG0076	glutamate decarboxylase activity
LP316_RS05200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LP316_RS05205	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LP316_RS05210	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LP316_RS05260	COG1643	Atp-dependent helicase
LP316_RS05265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LP316_RS05270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LP316_RS05275	COG0540	Belongs to the ATCase OTCase family
LP316_RS05285	COG4783	chaperone-mediated protein folding
LP316_RS05295	COG1981	membrane
LP316_RS05310	COG0316	Belongs to the HesB IscA family
LP316_RS05365	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LP316_RS05370	COG0557	exoribonuclease II activity
LP316_RS05375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LP316_RS05380	COG0589	response to stress
LP316_RS05395	COG2965	DNA replication, synthesis of RNA primer
LP316_RS05400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LP316_RS05405	COG0359	binds to the 23S rRNA
LP316_RS05410	COG2200	EAL domain
LP316_RS05410	COG2199	diguanylate cyclase activity
LP316_RS05445	COG3409	Peptidoglycan-binding domain 1 protein
LP316_RS05445	COG3267	Type II secretory pathway component ExeA
LP316_RS05455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LP316_RS05460	COG1459	type II secretion system
LP316_RS05470	COG2165	general secretion pathway protein
LP316_RS05475	COG2165	general secretion pathway protein
LP316_RS05480	COG2165	general secretion pathway protein
LP316_RS05505	COG1077	Cell shape determining protein MreB Mrl
LP316_RS05510	COG1792	Involved in formation and maintenance of cell shape
LP316_RS05515	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LP316_RS05520	COG0424	maF-like protein
LP316_RS05525	COG1530	ribonuclease E activity
LP316_RS05530	COG3164	Protein of unknown function
LP316_RS05535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LP316_RS05540	COG0312	modulator of DNA gyrase
LP316_RS05545	COG4628	conserved protein (DUF2132)
LP316_RS05555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LP316_RS05560	COG0166	Belongs to the GPI family
LP316_RS05565	COG0179	Fumarylacetoacetate (FAA) hydrolase
LP316_RS05570	COG3706	GGDEF domain
LP316_RS05580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LP316_RS05585	COG0436	Aminotransferase
LP316_RS05590	COG1082	Xylose isomerase domain protein TIM barrel
LP316_RS05660	COG2205	protein histidine kinase activity
LP316_RS05665	COG0745	RESPONSE REGULATOR receiver
LP316_RS05690	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LP316_RS05695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LP316_RS05700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LP316_RS05705	COG0723	plastoquinol--plastocyanin reductase activity
LP316_RS05710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LP316_RS05715	COG2857	Cytochrome c1
LP316_RS05725	COG0625	glutathione transferase activity
LP316_RS05730	COG2969	positive regulation of protein catabolic process
LP316_RS05735	COG1607	acyl-coa hydrolase
LP316_RS05745	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LP316_RS05755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LP316_RS05765	COG1309	transcriptional regulator
LP316_RS05775	COG2311	Membrane
LP316_RS05780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LP316_RS05790	COG1640	4-alpha-glucanotransferase
LP316_RS05800	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LP316_RS05805	COG0058	SHG alpha-glucan phosphorylase activity
LP316_RS05815	COG1538	Outer membrane efflux protein
LP316_RS05820	COG0494	nUDIX hydrolase
LP316_RS05835	COG3150	esterase
LP316_RS05845	COG0010	Belongs to the arginase family
LP316_RS05850	COG1166	arginine decarboxylase activity
LP316_RS05855	COG1253	flavin adenine dinucleotide binding
LP316_RS05860	COG1982	Orn Lys Arg decarboxylase major
LP316_RS05865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LP316_RS05910	COG0583	DNA-binding transcription factor activity
LP316_RS05915	COG4771	TonB-dependent receptor
LP316_RS05930	COG1858	cytochrome C peroxidase
LP316_RS05960	COG0583	DNA-binding transcription factor activity
LP316_RS05965	COG2259	Doxx family
LP316_RS05970	COG1741	Belongs to the pirin family
LP316_RS05975	COG0435	Glutathione S-transferase
LP316_RS05995	COG2119	membrane
LP316_RS06000	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LP316_RS06005	COG1194	a g-specific adenine glycosylase
LP316_RS06010	COG3171	Protein conserved in bacteria
LP316_RS06015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LP316_RS06030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LP316_RS06055	COG0659	secondary active sulfate transmembrane transporter activity
LP316_RS06060	COG3313	Fe-S protein
LP316_RS06075	COG4191	Histidine kinase
LP316_RS06075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LP316_RS06080	COG3437	response regulator, receiver
LP316_RS06080	COG0784	Response regulator, receiver
LP316_RS06095	COG4555	ABC transporter
LP316_RS06105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LP316_RS06115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LP316_RS06115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LP316_RS06140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LP316_RS06145	COG0142	geranyltranstransferase activity
LP316_RS06150	COG1722	exodeoxyribonuclease VII activity
LP316_RS06155	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LP316_RS06165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LP316_RS06165	COG0301	tRNA thio-modification
LP316_RS06180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LP316_RS06190	COG1666	GTP binding
LP316_RS06195	COG0733	neurotransmitter:sodium symporter activity
LP316_RS06200	COG0564	pseudouridine synthase activity
LP316_RS06205	COG1757	Na H antiporter
LP316_RS06210	COG2918	glutathione biosynthetic process
LP316_RS06220	COG4536	flavin adenine dinucleotide binding
LP316_RS06235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LP316_RS06240	COG1404	Belongs to the peptidase S8 family
LP316_RS06245	COG3028	Belongs to the UPF0307 family
LP316_RS06250	COG0312	modulator of DNA gyrase
LP316_RS06255	COG2239	Acts as a magnesium transporter
LP316_RS06260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LP316_RS06265	COG1660	Displays ATPase and GTPase activities
LP316_RS06270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LP316_RS06275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LP316_RS06280	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LP316_RS06285	COG1137	ATPase activity
LP316_RS06305	COG0517	IMP dehydrogenase activity
LP316_RS06305	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LP316_RS06315	COG1127	ABC transporter
LP316_RS06320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LP316_RS06325	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LP316_RS06330	COG2854	intermembrane phospholipid transfer
LP316_RS06340	COG5007	Belongs to the BolA IbaG family
LP316_RS06350	COG3409	Peptidoglycan-binding domain 1 protein
LP316_RS06350	COG3267	Type II secretory pathway component ExeA
LP316_RS06370	COG0066	3-isopropylmalate dehydratase activity
LP316_RS06375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LP316_RS06380	COG0473	3-isopropylmalate dehydrogenase activity
LP316_RS06385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LP316_RS06405	COG4991	sh3 domain protein
LP316_RS06415	COG1388	LysM domain
LP316_RS06415	COG1376	ErfK ybiS ycfS ynhG family protein
LP316_RS06445	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LP316_RS06470	COG1560	Kdo2-lipid A biosynthetic process
LP316_RS06475	COG0438	transferase activity, transferring glycosyl groups
LP316_RS06480	COG0228	four-way junction DNA binding
LP316_RS06485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LP316_RS06490	COG0336	Belongs to the RNA methyltransferase TrmD family
LP316_RS06505	COG0028	Belongs to the TPP enzyme family
LP316_RS06515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LP316_RS06520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LP316_RS06525	COG1605	Chorismate mutase
LP316_RS06525	COG0287	Prephenate dehydrogenase
LP316_RS06560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LP316_RS06570	COG1605	Chorismate mutase
LP316_RS06570	COG0077	Prephenate dehydratase
LP316_RS06585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LP316_RS06590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LP316_RS06610	COG0259	pyridoxamine-phosphate oxidase activity
LP316_RS06615	COG1473	amidohydrolase
LP316_RS06625	COG3005	denitrification pathway
LP316_RS06630	COG3043	anaerobic respiration
LP316_RS06635	COG0243	molybdopterin cofactor binding
LP316_RS06655	COG1444	tRNA N-acetyltransferase activity
LP316_RS06660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LP316_RS06675	COG3085	chromosome segregation
LP316_RS06680	COG3130	regulation of translation
LP316_RS06685	COG1104	cysteine desulfurase activity
LP316_RS06690	COG0281	malic enzyme
LP316_RS06695	COG0105	UTP biosynthetic process
LP316_RS06700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LP316_RS06715	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LP316_RS06720	COG0124	histidyl-tRNA synthetase
LP316_RS06725	COG2976	Protein conserved in bacteria
LP316_RS06730	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LP316_RS06735	COG1160	GTP binding
LP316_RS06750	COG0516	GMP reductase activity
LP316_RS06750	COG0517	IMP dehydrogenase activity
LP316_RS06755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LP316_RS06755	COG0519	Catalyzes the synthesis of GMP from XMP
LP316_RS06775	COG1671	Belongs to the UPF0178 family
LP316_RS06815	COG0271	Belongs to the BolA IbaG family
LP316_RS06830	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LP316_RS06840	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LP316_RS06850	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LP316_RS06855	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LP316_RS06860	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LP316_RS06865	COG2871	sodium ion transport
LP316_RS06870	COG1477	protein flavinylation
LP316_RS06875	COG2991	Protein conserved in bacteria
LP316_RS06880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LP316_RS06890	COG2974	May be involved in recombination
LP316_RS06895	COG4191	Histidine kinase
LP316_RS06895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LP316_RS06905	COG0745	RESPONSE REGULATOR receiver
LP316_RS06910	COG5002	protein histidine kinase activity
LP316_RS06925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LP316_RS06940	COG0488	(ABC) transporter
LP316_RS06945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LP316_RS06955	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LP316_RS06970	COG0415	Belongs to the DNA photolyase family
LP316_RS06980	COG3806	Anti-sigma factor
LP316_RS06985	COG1595	DNA-templated transcription, initiation
LP316_RS06995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LP316_RS07000	COG0517	IMP dehydrogenase activity
LP316_RS07000	COG0516	GMP reductase activity
LP316_RS07020	COG1960	acyl-CoA dehydrogenase activity
LP316_RS07030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LP316_RS07040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LP316_RS07045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LP316_RS07055	COG0513	Belongs to the DEAD box helicase family
LP316_RS07075	COG3022	response to hydroperoxide
LP316_RS07080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LP316_RS07100	COG1733	regulation of RNA biosynthetic process
LP316_RS07135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LP316_RS07155	COG0835	chemotaxis
LP316_RS07155	COG0784	Response regulator, receiver
LP316_RS07160	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LP316_RS07165	COG1815	bacterial-type flagellum-dependent cell motility
LP316_RS07195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LP316_RS07200	COG1706	bacterial-type flagellum-dependent cell motility
LP316_RS07205	COG1705	Flagellar rod assembly protein muramidase FlgJ
LP316_RS07205	COG3951	Flagellar rod assembly protein muramidase FlgJ
LP316_RS07210	COG1256	bacterial-type flagellum assembly
LP316_RS07225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LP316_RS07245	COG1516	flagellar protein fliS
LP316_RS07260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LP316_RS07265	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LP316_RS07270	COG2089	acid synthase
LP316_RS07280	COG0673	inositol 2-dehydrogenase activity
LP316_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
LP316_RS07315	COG1677	Flagellar hook-basal body complex protein FliE
LP316_RS07325	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LP316_RS07375	COG1987	bacterial-type flagellum assembly
LP316_RS07415	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LP316_RS07420	COG0643	Histidine kinase
LP316_RS07420	COG0784	Response regulator, receiver
LP316_RS07420	COG2198	Histidine kinase
LP316_RS07430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LP316_RS07435	COG1360	Flagellar Motor Protein
LP316_RS07440	COG1192	Involved in chromosome partitioning
LP316_RS07450	COG0835	chemotaxis
LP316_RS07460	COG2853	Lipoprotein
LP316_RS07475	COG1472	Belongs to the glycosyl hydrolase 3 family
LP316_RS07480	COG0471	metal ion transport
LP316_RS07490	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LP316_RS07500	COG2719	SpoVR family
LP316_RS07505	COG2718	Belongs to the UPF0229 family
LP316_RS07510	COG2766	serine protein kinase
LP316_RS07535	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LP316_RS07540	COG0450	alkyl hydroperoxide reductase
LP316_RS07545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LP316_RS07560	COG4172	Belongs to the ABC transporter superfamily
LP316_RS07565	COG4172	Belongs to the ABC transporter superfamily
LP316_RS07575	COG0601	transmembrane transport
LP316_RS07580	COG0747	negative chemotaxis
LP316_RS07585	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LP316_RS07590	COG1842	Phage shock protein A
LP316_RS07605	COG3106	COG3106 Predicted ATPase
LP316_RS07610	COG3768	UPF0283 membrane protein
LP316_RS07620	COG2154	pterin-4-alpha-carbinolamine dehydratase
LP316_RS07635	COG0625	glutathione transferase activity
LP316_RS07665	COG0730	response to heat
LP316_RS07690	COG0457	Tetratricopeptide repeat
LP316_RS07710	COG0811	peptide transport
LP316_RS07715	COG0811	peptide transport
LP316_RS07720	COG0848	biopolymer transport protein
LP316_RS07735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LP316_RS07750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LP316_RS07755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LP316_RS07760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LP316_RS07815	COG1566	PFAM secretion protein HlyD family protein
LP316_RS07835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LP316_RS07840	COG0326	Molecular chaperone. Has ATPase activity
LP316_RS07880	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LP316_RS07885	COG0346	lactoylglutathione lyase activity
LP316_RS07890	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LP316_RS07895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LP316_RS07900	COG4660	Part of a membrane complex involved in electron transport
LP316_RS07905	COG4659	FMN binding
LP316_RS07910	COG4658	electron transport chain
LP316_RS07915	COG4656	Part of a membrane complex involved in electron transport
LP316_RS07920	COG2878	Part of a membrane complex involved in electron transport
LP316_RS07925	COG4657	Part of a membrane complex involved in electron transport
LP316_RS07935	COG0779	Required for maturation of 30S ribosomal subunits
LP316_RS07940	COG0195	Participates in both transcription termination and antitermination
LP316_RS07945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LP316_RS07950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LP316_RS07955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LP316_RS07960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LP316_RS07970	COG1185	polyribonucleotide nucleotidyltransferase activity
LP316_RS07990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LP316_RS07995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LP316_RS08005	COG2009	succinate dehydrogenase
LP316_RS08010	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LP316_RS08015	COG1053	succinate dehydrogenase
LP316_RS08025	COG0567	Dehydrogenase, E1 component
LP316_RS08030	COG0508	dehydrogenase complex catalyzes the overall conversion of
LP316_RS08045	COG0045	succinate-CoA ligase (ADP-forming) activity
LP316_RS08050	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LP316_RS08085	COG4628	conserved protein (DUF2132)
LP316_RS08110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LP316_RS08115	COG0735	belongs to the Fur family
LP316_RS08125	COG0716	FMN binding
LP316_RS08140	COG0596	Alpha beta hydrolase
LP316_RS08140	COG0508	dehydrogenase complex catalyzes the overall conversion of
LP316_RS08150	COG0033	Phosphoglucomutase
LP316_RS08155	COG2988	succinylglutamate desuccinylase activity
LP316_RS08165	COG0022	dehydrogenase e1 component
LP316_RS08185	COG0515	serine threonine protein kinase
LP316_RS08195	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LP316_RS08205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LP316_RS08210	COG2226	methyltransferase
LP316_RS08220	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LP316_RS08225	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LP316_RS08230	COG0632	four-way junction helicase activity
LP316_RS08235	COG2255	four-way junction helicase activity
LP316_RS08250	COG0824	Thioesterase
LP316_RS08255	COG0811	peptide transport
LP316_RS08270	COG0823	Involved in the tonB-independent uptake of proteins
LP316_RS08275	COG2885	chlorophyll binding
LP316_RS08280	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LP316_RS08300	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LP316_RS08320	COG3119	arylsulfatase activity
LP316_RS08325	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LP316_RS08330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LP316_RS08335	COG0215	cysteine-tRNA ligase activity
LP316_RS08350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LP316_RS08380	COG0544	peptidyl-prolyl cis-trans isomerase activity
LP316_RS08385	COG0740	serine-type endopeptidase activity
LP316_RS08390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LP316_RS08395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LP316_RS08405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LP316_RS08415	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LP316_RS08420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LP316_RS08430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LP316_RS08435	COG3547	Transposase (IS116 IS110 IS902 family)
LP316_RS08440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LP316_RS08445	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LP316_RS08450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LP316_RS08455	COG3104	oligopeptide transport
LP316_RS08460	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LP316_RS08470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LP316_RS08500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LP316_RS08505	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LP316_RS08570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LP316_RS08590	COG0175	sulfate reduction
LP316_RS08600	COG2895	sulfate adenylyltransferase (ATP) activity
LP316_RS08605	COG0471	metal ion transport
LP316_RS08605	COG0490	domain, Protein
LP316_RS08610	COG0529	Catalyzes the synthesis of activated sulfate
LP316_RS08620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LP316_RS08625	COG3547	Transposase (IS116 IS110 IS902 family)
LP316_RS08645	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LP316_RS08660	COG2304	oxidoreductase activity
LP316_RS08680	COG0714	Associated with various cellular activities
LP316_RS08685	COG0183	Belongs to the thiolase family
LP316_RS08710	COG1025	Belongs to the peptidase M16 family
LP316_RS08715	COG2062	phosphohistidine phosphatase, SixA
LP316_RS08720	COG2840	Smr protein MutS2
LP316_RS08730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LP316_RS08735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LP316_RS08740	COG0321	lipoyl(octanoyl) transferase activity
LP316_RS08745	COG2921	Belongs to the UPF0250 family
LP316_RS08750	COG1686	Belongs to the peptidase S11 family
LP316_RS08755	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LP316_RS08760	COG0772	Belongs to the SEDS family
LP316_RS08765	COG0768	penicillin binding
LP316_RS08770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LP316_RS08775	COG0799	negative regulation of ribosome biogenesis
LP316_RS08780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LP316_RS08790	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LP316_RS08795	COG0495	leucyl-tRNA aminoacylation
LP316_RS08800	COG2888	peptidyl-tyrosine sulfation
LP316_RS08815	COG1067	ATP-dependent peptidase activity
LP316_RS08820	COG0513	Belongs to the DEAD box helicase family
LP316_RS08830	COG0288	reversible hydration of carbon dioxide
LP316_RS08835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LP316_RS08845	COG0840	transmembrane signaling receptor activity
LP316_RS08850	COG2957	Belongs to the agmatine deiminase family
LP316_RS08860	COG4591	ABC-type transport system involved in lipoprotein release permease component
LP316_RS08870	COG4591	ABC-type transport system involved in lipoprotein release permease component
LP316_RS08880	COG0658	competence protein
LP316_RS08880	COG2333	competence protein COMEC
LP316_RS08885	COG1132	(ABC) transporter
LP316_RS08895	COG2835	tetraacyldisaccharide 4'-kinase activity
LP316_RS08900	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LP316_RS08920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LP316_RS08925	COG3844	kynureninase activity
LP316_RS08935	COG0662	Cupin 2, conserved barrel domain protein
LP316_RS08955	COG0596	Alpha beta hydrolase
LP316_RS08970	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LP316_RS08975	COG2201	protein-glutamate methylesterase activity
LP316_RS08980	COG3706	GGDEF domain
LP316_RS08985	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LP316_RS08990	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LP316_RS08995	COG4535	Mg2 and Co2 transporter CorC
LP316_RS09005	COG1702	phosphate starvation-inducible protein PhoH
LP316_RS09010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LP316_RS09030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LP316_RS09080	COG0193	aminoacyl-tRNA hydrolase activity
LP316_RS09085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LP316_RS09120	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LP316_RS09125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LP316_RS09130	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LP316_RS09135	COG2890	protein-(glutamine-N5) methyltransferase activity
LP316_RS09145	COG2912	Transglutaminase-like superfamily
LP316_RS09155	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LP316_RS09165	COG0583	DNA-binding transcription factor activity
LP316_RS09180	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LP316_RS09190	COG0473	3-isopropylmalate dehydrogenase activity
LP316_RS09200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LP316_RS09205	COG1611	Belongs to the LOG family
LP316_RS09260	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LP316_RS09265	COG0436	Aminotransferase
LP316_RS09275	COG0442	prolyl-tRNA aminoacylation
LP316_RS09300	COG1609	Transcriptional regulator
LP316_RS09305	COG2211	Major facilitator Superfamily
LP316_RS09375	COG1280	lysine exporter protein (LysE YggA)
LP316_RS09405	COG0527	aspartate kinase activity
LP316_RS09415	COG0367	asparagine synthase
LP316_RS09425	COG0741	lytic transglycosylase activity
LP316_RS09425	COG1388	LysM domain
LP316_RS09435	COG2226	methyltransferase
LP316_RS09440	COG0612	Peptidase, M16
LP316_RS09445	COG4771	TonB-dependent receptor
LP316_RS09450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LP316_RS09460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LP316_RS09480	COG4771	TonB-dependent receptor
LP316_RS09500	COG1960	acyl-CoA dehydrogenase activity
LP316_RS09535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LP316_RS09540	COG2211	Major facilitator Superfamily
LP316_RS09545	COG3459	Glycosyltransferase 36 associated
LP316_RS09550	COG3265	gluconokinase activity
LP316_RS09555	COG3693	PFAM glycoside hydrolase, family 10
LP316_RS09560	COG1472	Belongs to the glycosyl hydrolase 3 family
LP316_RS09570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LP316_RS09570	COG3153	acetyltransferase
LP316_RS09580	COG0528	UMP kinase activity
LP316_RS09585	COG0233	cytoplasmic translational termination
LP316_RS09590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LP316_RS09595	COG0575	Belongs to the CDS family
LP316_RS09600	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LP316_RS09605	COG0750	zinc metalloprotease
LP316_RS09620	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LP316_RS09625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LP316_RS09635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LP316_RS09640	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LP316_RS09645	COG0587	DNA-directed DNA polymerase activity
LP316_RS09650	COG0825	malonyl-CoA metabolic process
LP316_RS09665	COG2161	toxin-antitoxin pair type II binding
LP316_RS09670	COG4115	mRNA cleavage
LP316_RS09680	COG3724	N-succinylarginine dihydrolase activity
LP316_RS09685	COG2326	polyphosphate kinase activity
LP316_RS09705	COG0563	adenylate kinase activity
LP316_RS09710	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LP316_RS09725	COG0140	phosphoribosyl-ATP diphosphatase activity
LP316_RS09725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LP316_RS09730	COG0107	imidazoleglycerol-phosphate synthase activity
LP316_RS09735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LP316_RS09740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LP316_RS09745	COG0131	Imidazoleglycerol-phosphate dehydratase
LP316_RS09745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LP316_RS09755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LP316_RS09760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LP316_RS09770	COG1199	ATP-dependent helicase activity
LP316_RS09790	COG0596	Alpha beta hydrolase
LP316_RS09795	COG0318	PFAM AMP-dependent synthetase and ligase
LP316_RS09800	COG1028	Short-chain dehydrogenase reductase Sdr
LP316_RS09805	COG2267	carboxylic ester hydrolase activity
LP316_RS09810	COG0616	signal peptide processing
LP316_RS09820	COG1301	dicarboxylic acid transport
LP316_RS09835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LP316_RS09840	COG1846	Transcriptional regulator
LP316_RS09845	COG0386	Belongs to the glutathione peroxidase family
LP316_RS09850	COG2084	Dehydrogenase
LP316_RS09860	COG2925	Exonuclease
LP316_RS09870	COG3706	GGDEF domain
LP316_RS09885	COG2176	DNA-directed DNA polymerase activity
LP316_RS09900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LP316_RS09910	COG0440	acetolactate synthase activity
LP316_RS09915	COG0028	Belongs to the TPP enzyme family
LP316_RS09925	COG2203	Gaf domain
LP316_RS09925	COG5001	Diguanylate cyclase
LP316_RS09925	COG4251	negative regulation of phosphorylation
LP316_RS09925	COG3706	GGDEF domain
LP316_RS09930	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LP316_RS09980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LP316_RS09985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LP316_RS09995	COG1090	epimerase
LP316_RS10010	COG0134	indole-3-glycerol-phosphate synthase activity
LP316_RS10010	COG0135	phosphoribosylanthranilate isomerase activity
LP316_RS10025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LP316_RS10030	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LP316_RS10035	COG0613	PHP domain protein
LP316_RS10045	COG1024	Enoyl-CoA hydratase
LP316_RS10050	COG0009	L-threonylcarbamoyladenylate synthase
LP316_RS10060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LP316_RS10065	COG1187	pseudouridine synthase activity
LP316_RS10080	COG2951	lytic endotransglycosylase activity
LP316_RS10085	COG2983	Belongs to the UPF0260 family
LP316_RS10095	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LP316_RS10100	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LP316_RS10105	COG1115	amino acid carrier protein
LP316_RS10115	COG0513	Belongs to the DEAD box helicase family
LP316_RS10130	COG0454	-acetyltransferase
LP316_RS10140	COG3431	PFAM Phosphate-starvation-inducible E
LP316_RS10165	COG3706	GGDEF domain
LP316_RS10175	COG0625	glutathione transferase activity
LP316_RS10195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LP316_RS10205	COG4770	biotin carboxylase activity
LP316_RS10210	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LP316_RS10215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LP316_RS10220	COG1960	acyl-CoA dehydrogenase activity
LP316_RS10230	COG0183	Belongs to the thiolase family
LP316_RS10240	COG1024	Enoyl-CoA hydratase
LP316_RS10245	COG1024	Enoyl-CoA hydratase
LP316_RS10245	COG1250	3-hydroxyacyl-CoA dehydrogenase
LP316_RS10255	COG1028	Short-chain dehydrogenase reductase Sdr
LP316_RS10295	COG0488	(ABC) transporter
LP316_RS10300	COG1032	radical SAM domain protein
LP316_RS10320	COG0405	Gamma-glutamyltransferase
LP316_RS10345	COG0542	response to heat
LP316_RS10355	COG1714	RDD family
LP316_RS10365	COG1803	Methylglyoxal synthase
LP316_RS10380	COG3609	addiction module antidote protein, CC2985 family
LP316_RS10400	COG0420	3'-5' exonuclease activity
LP316_RS10405	COG0419	ATPase involved in DNA repair
LP316_RS10415	COG1228	amidohydrolase
LP316_RS10425	COG1720	tRNA m6t6A37 methyltransferase activity
LP316_RS10435	COG1301	dicarboxylic acid transport
LP316_RS10460	COG1054	Belongs to the UPF0176 family
LP316_RS10480	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LP316_RS10490	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LP316_RS10490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LP316_RS10495	COG0489	protein tyrosine kinase activity
LP316_RS10500	COG0717	Belongs to the dCTP deaminase family
LP316_RS10540	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LP316_RS10550	COG4181	ATPase activity
LP316_RS10555	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LP316_RS10560	COG0628	permease
LP316_RS10570	COG2350	Protein conserved in bacteria
LP316_RS10585	COG0745	RESPONSE REGULATOR receiver
LP316_RS10600	COG0835	chemotaxis
LP316_RS10605	COG0840	transmembrane signaling receptor activity
LP316_RS10610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LP316_RS10615	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LP316_RS10630	COG2204	response regulator
LP316_RS10635	COG5001	Diguanylate cyclase
LP316_RS10635	COG4251	negative regulation of phosphorylation
LP316_RS10635	COG2203	Gaf domain
LP316_RS10635	COG3706	GGDEF domain
LP316_RS10650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LP316_RS10655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LP316_RS10665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LP316_RS10690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LP316_RS10695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LP316_RS10700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LP316_RS10705	COG0539	negative regulation of cytoplasmic translation
LP316_RS10710	COG0776	regulation of translation
LP316_RS10720	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LP316_RS10725	COG0284	orotidine-5'-phosphate decarboxylase activity
LP316_RS10730	COG1555	photosystem II stabilization
LP316_RS10730	COG1596	polysaccharide export
LP316_RS10750	COG1399	metal-binding, possibly nucleic acid-binding protein
LP316_RS10755	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LP316_RS10760	COG0416	fatty acid biosynthetic process
LP316_RS10765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LP316_RS10770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LP316_RS10780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LP316_RS10785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LP316_RS10790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LP316_RS10795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LP316_RS10800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LP316_RS10805	COG0470	DNA polymerase III
LP316_RS10815	COG0084	hydrolase, TatD family'
LP316_RS10820	COG0700	Nucleoside recognition
LP316_RS10830	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LP316_RS10835	COG0372	Belongs to the citrate synthase family
LP316_RS10850	COG1115	amino acid carrier protein
LP316_RS10870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LP316_RS10880	COG1944	ATP diphosphatase activity
LP316_RS10895	COG0277	FAD linked oxidase domain protein
LP316_RS10895	COG0247	lactate metabolic process
LP316_RS10900	COG1785	Belongs to the alkaline phosphatase family
LP316_RS10910	COG1309	transcriptional regulator
LP316_RS10920	COG3130	regulation of translation
LP316_RS10925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LP316_RS10935	COG2197	response regulator
LP316_RS10940	COG0322	excinuclease ABC activity
LP316_RS10995	COG4771	TonB-dependent receptor
LP316_RS11000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LP316_RS11015	COG0252	asparaginase activity
LP316_RS11020	COG0616	signal peptide processing
LP316_RS11030	COG0778	Nitroreductase
LP316_RS11035	COG0017	Asparaginyl-tRNA synthetase
LP316_RS11045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LP316_RS11050	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LP316_RS11055	COG0156	8-amino-7-oxononanoate synthase activity
LP316_RS11060	COG2226	methyltransferase
LP316_RS11065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LP316_RS11080	COG0469	pyruvate kinase activity
LP316_RS11085	COG1737	Transcriptional regulator
LP316_RS11090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LP316_RS11095	COG0363	glucosamine-6-phosphate deaminase activity
LP316_RS11100	COG0129	dihydroxy-acid dehydratase activity
LP316_RS11110	COG0800	Aldolase
LP316_RS11125	COG5001	Diguanylate cyclase
LP316_RS11130	COG2199	diguanylate cyclase activity
LP316_RS11145	COG3082	Protein of unknown function (DUF1414)
LP316_RS11150	COG3081	Nucleoid-associated protein
LP316_RS11180	COG0243	molybdopterin cofactor binding
LP316_RS11190	COG2146	nitrite reductase [NAD(P)H] activity
LP316_RS11190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LP316_RS11200	COG1116	anion transmembrane transporter activity
LP316_RS11205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LP316_RS11210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LP316_RS11215	COG3707	response regulator
LP316_RS11230	COG3279	Response regulator of the LytR AlgR family
LP316_RS11235	COG2972	Histidine kinase
LP316_RS11245	COG3201	nicotinamide mononucleotide transporter
LP316_RS11255	COG4774	siderophore transport
LP316_RS11255	COG1629	transport
LP316_RS11260	COG0537	adenosine 5'-monophosphoramidase activity
LP316_RS11265	COG0626	cystathionine gamma-synthase activity
LP316_RS11270	COG0417	DNA replication proofreading
LP316_RS11275	COG1199	ATP-dependent helicase activity
LP316_RS11295	COG0602	queuosine metabolic process
LP316_RS11300	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LP316_RS11315	COG1187	pseudouridine synthase activity
LP316_RS11325	COG0482	sulfurtransferase activity
LP316_RS11330	COG2915	High frequency lysogenization protein hflD homolog
LP316_RS11335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LP316_RS11340	COG2850	peptidyl-arginine hydroxylation
LP316_RS11355	COG0574	Belongs to the PEP-utilizing enzyme family
LP316_RS11355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LP316_RS11360	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LP316_RS11365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LP316_RS11385	COG2200	EAL domain
LP316_RS11385	COG2199	diguanylate cyclase activity
LP316_RS11385	COG2202	Pas domain
LP316_RS11390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LP316_RS11395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LP316_RS11405	COG0813	purine-nucleoside phosphorylase activity
LP316_RS11415	COG4771	TonB-dependent receptor
LP316_RS11425	COG0572	uridine kinase
LP316_RS11430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LP316_RS11435	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LP316_RS11440	COG1435	thymidine kinase activity
LP316_RS11470	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
LP316_RS11475	COG2944	sequence-specific DNA binding
LP316_RS11480	COG2161	toxin-antitoxin pair type II binding
LP316_RS11485	COG4115	mRNA cleavage
LP316_RS11495	COG0295	cytidine deaminase activity
LP316_RS11505	COG0488	(ABC) transporter
LP316_RS11515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LP316_RS11515	COG0116	Belongs to the methyltransferase superfamily
LP316_RS11540	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LP316_RS11555	COG1254	Belongs to the acylphosphatase family
LP316_RS11560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LP316_RS11575	COG1643	Atp-dependent helicase
LP316_RS11580	COG4109	DRTGG domain
LP316_RS11585	COG1446	asparaginase
LP316_RS11595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LP316_RS11600	COG1074	ATP-dependent DNA helicase activity
LP316_RS11605	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LP316_RS11630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LP316_RS11640	COG0640	Transcriptional regulator
LP316_RS11670	COG0612	Peptidase, M16
LP316_RS11815	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LP316_RS11820	COG0167	dihydroorotate dehydrogenase activity
LP316_RS11825	COG2902	Dehydrogenase
LP316_RS11855	COG0308	aminopeptidase N
LP316_RS11860	COG1757	Na H antiporter
LP316_RS11870	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LP316_RS11880	COG1956	GAF domain-containing protein
LP316_RS11895	COG0519	Catalyzes the synthesis of GMP from XMP
LP316_RS11900	COG0670	Belongs to the BI1 family
LP316_RS11910	COG2923	Belongs to the DsrF TusC family
LP316_RS11920	COG2920	part of a sulfur-relay system
LP316_RS11945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LP316_RS11950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LP316_RS11965	COG3139	Protein of unknown function (DUF1315)
LP316_RS11975	COG1115	amino acid carrier protein
LP316_RS11980	COG2866	Carboxypeptidase
LP316_RS11990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LP316_RS11995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LP316_RS12000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LP316_RS12005	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LP316_RS12010	COG1674	ftsk spoiiie
LP316_RS12010	COG0531	amino acid
LP316_RS12020	COG0686	Belongs to the AlaDH PNT family
LP316_RS12025	COG0492	ferredoxin-NADP+ reductase activity
LP316_RS12035	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LP316_RS12040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LP316_RS12045	COG0542	response to heat
LP316_RS12050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LP316_RS12055	COG1278	Cold shock
LP316_RS12070	COG0556	nucleotide-excision repair
LP316_RS12075	COG0534	Mate efflux family protein
LP316_RS12095	COG1280	lysine exporter protein (LysE YggA)
LP316_RS12105	COG3278	Belongs to the heme-copper respiratory oxidase family
LP316_RS12120	COG2010	Cytochrome c
LP316_RS12130	COG2217	Heavy metal translocating P-type atpase
LP316_RS12150	COG0589	response to stress
LP316_RS12155	COG0037	tRNA processing
LP316_RS12160	COG2252	PERMEase
LP316_RS12180	COG1280	lysine exporter protein (LysE YggA)
LP316_RS12190	COG5265	(ABC) transporter
LP316_RS12195	COG0776	regulation of translation
LP316_RS12200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LP316_RS12200	COG0072	phenylalanine-tRNA ligase activity
LP316_RS12205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LP316_RS12210	COG4807	Protein conserved in bacteria
LP316_RS12215	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LP316_RS12220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LP316_RS12225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LP316_RS12230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LP316_RS12235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LP316_RS12245	COG3001	Fructosamine kinase
LP316_RS12255	COG0307	riboflavin synthase, alpha
LP316_RS12260	COG0534	Mate efflux family protein
LP316_RS12310	COG3119	arylsulfatase activity
LP316_RS12315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LP316_RS12320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LP316_RS12340	COG1131	(ABC) transporter
LP316_RS12345	COG0071	Belongs to the small heat shock protein (HSP20) family
LP316_RS12355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LP316_RS12360	COG0583	DNA-binding transcription factor activity
LP316_RS12405	COG0714	Associated with various cellular activities
LP316_RS12410	COG3119	arylsulfatase activity
LP316_RS12435	COG2234	aminopeptidase activity
LP316_RS12445	COG3706	GGDEF domain
LP316_RS12455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LP316_RS12475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LP316_RS12490	COG3437	response regulator, receiver
LP316_RS12490	COG0784	Response regulator, receiver
LP316_RS12495	COG5002	protein histidine kinase activity
LP316_RS12505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LP316_RS12510	COG0052	Belongs to the universal ribosomal protein uS2 family
LP316_RS12520	COG0024	Methionine aminopeptidase
LP316_RS12525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LP316_RS12530	COG2171	N-acyltransferase activity
LP316_RS12575	COG1253	flavin adenine dinucleotide binding
LP316_RS12635	COG2207	Transcriptional regulator
LP316_RS12640	COG4771	TonB-dependent receptor
LP316_RS12660	COG2315	Protein conserved in bacteria
LP316_RS12665	COG1187	pseudouridine synthase activity
LP316_RS12675	COG1476	TRANSCRIPTIONal
LP316_RS12685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LP316_RS12695	COG0733	neurotransmitter:sodium symporter activity
LP316_RS12700	COG0401	homolog of Blt101
LP316_RS12715	COG0471	metal ion transport
LP316_RS12715	COG3273	potassium ion transport
LP316_RS12730	COG0494	nUDIX hydrolase
LP316_RS12735	COG1760	l-serine dehydratase
LP316_RS12740	COG0583	DNA-binding transcription factor activity
LP316_RS12760	COG3012	SEC-C Motif Domain Protein
LP316_RS12770	COG2205	protein histidine kinase activity
LP316_RS12775	COG0745	RESPONSE REGULATOR receiver
LP316_RS12785	COG0708	Exodeoxyribonuclease III
LP316_RS12790	COG2226	methyltransferase
LP316_RS12795	COG3092	negative regulation of chromosome organization
LP316_RS12800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LP316_RS12805	COG0280	phosphate acetyltransferase
LP316_RS12805	COG0857	belongs to the CobB CobQ family
LP316_RS12815	COG1393	Belongs to the ArsC family
LP316_RS12820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LP316_RS12825	COG1876	peptidase activity
LP316_RS12840	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LP316_RS12845	COG2716	regulation of RNA biosynthetic process
LP316_RS12850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LP316_RS12870	COG4783	chaperone-mediated protein folding
LP316_RS12875	COG1393	Belongs to the ArsC family
LP316_RS12890	COG5507	3-demethylubiquinone-9 3-methyltransferase
LP316_RS12895	COG0640	Transcriptional regulator
LP316_RS12900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LP316_RS12920	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LP316_RS12925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LP316_RS12935	COG0121	glutamine amidotransferase
LP316_RS12940	COG1960	acyl-CoA dehydrogenase activity
LP316_RS12945	COG0204	Acyl-transferase
LP316_RS12950	COG3547	Transposase (IS116 IS110 IS902 family)
LP316_RS12985	COG0328	RNA-DNA hybrid ribonuclease activity
LP316_RS12990	COG3453	Protein conserved in bacteria
LP316_RS12990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LP316_RS13015	COG2165	general secretion pathway protein
LP316_RS13020	COG2133	pyrroloquinoline quinone binding
LP316_RS13045	COG3279	Response regulator of the LytR AlgR family
LP316_RS13115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LP316_RS13125	COG0729	surface antigen
LP316_RS13130	COG2911	Protein conserved in bacteria
LP316_RS13140	COG2165	general secretion pathway protein
LP316_RS13175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LP316_RS13180	COG0149	triose-phosphate isomerase activity
LP316_RS13185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LP316_RS13190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LP316_RS13195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LP316_RS13200	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LP316_RS13205	COG1534	Rna-binding protein
LP316_RS13220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LP316_RS13225	COG0505	Belongs to the CarA family
LP316_RS13230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LP316_RS13240	COG0545	Peptidyl-prolyl cis-trans isomerase
LP316_RS13255	COG5002	protein histidine kinase activity
LP316_RS13265	COG0745	RESPONSE REGULATOR receiver
LP316_RS13325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LP316_RS13340	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
LP316_RS13350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LP316_RS13370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LP316_RS13375	COG1286	toxin biosynthetic process
LP316_RS13385	COG0285	dihydrofolate synthase activity
LP316_RS13390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LP316_RS13395	COG0101	tRNA pseudouridine synthase activity
LP316_RS13415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LP316_RS13435	COG3101	peptidyl-lysine hydroxylation
LP316_RS13440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LP316_RS13450	COG0484	heat shock protein binding
LP316_RS13455	COG0443	Heat shock 70 kDa protein
LP316_RS13460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LP316_RS13465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LP316_RS13470	COG0497	DNA recombination
LP316_RS13475	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LP316_RS13480	COG2914	Belongs to the UPF0125 (RnfH) family
LP316_RS13485	COG2867	negative regulation of translational initiation
LP316_RS13490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LP316_RS13510	COG1024	Enoyl-CoA hydratase
LP316_RS13555	COG3148	PFAM DTW domain containing protein
LP316_RS13575	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LP316_RS13605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LP316_RS13625	COG1979	alcohol dehydrogenase
LP316_RS13650	COG0626	cystathionine gamma-synthase activity
LP316_RS13675	COG1902	pentaerythritol trinitrate reductase activity
LP316_RS13675	COG0446	pyridine nucleotide-disulphide oxidoreductase
LP316_RS13705	COG4989	oxidoreductase activity
LP316_RS13710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LP316_RS13725	COG2354	Protein conserved in bacteria
LP316_RS13730	COG2201	protein-glutamate methylesterase activity
LP316_RS13770	COG3547	Transposase (IS116 IS110 IS902 family)
LP316_RS13790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LP316_RS13795	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LP316_RS13800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LP316_RS13805	COG0126	phosphoglycerate kinase activity
LP316_RS13825	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LP316_RS13830	COG0583	DNA-binding transcription factor activity
LP316_RS13845	COG1380	Effector of murein hydrolase LrgA
LP316_RS13850	COG1346	cytolysis
LP316_RS13890	COG1595	DNA-templated transcription, initiation
LP316_RS13895	COG0583	DNA-binding transcription factor activity
LP316_RS13900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LP316_RS13905	COG0306	phosphate transporter
LP316_RS13910	COG1392	Phosphate transport regulator
LP316_RS13915	COG0704	Plays a role in the regulation of phosphate uptake
LP316_RS13920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LP316_RS13925	COG0573	inorganic phosphate transmembrane transporter activity
LP316_RS13930	COG0573	inorganic phosphate transmembrane transporter activity
LP316_RS13940	COG1597	lipid kinase activity
LP316_RS13950	COG0840	transmembrane signaling receptor activity
LP316_RS13960	COG3634	alkyl hydroperoxide reductase activity
LP316_RS13975	COG0714	Associated with various cellular activities
LP316_RS14000	COG0443	Heat shock 70 kDa protein
LP316_RS14015	COG0822	iron-sulfur transferase activity
LP316_RS14020	COG1104	cysteine desulfurase activity
LP316_RS14025	COG1959	2 iron, 2 sulfur cluster binding
LP316_RS14030	COG1045	serine acetyltransferase
LP316_RS14040	COG0483	inositol monophosphate 1-phosphatase activity
LP316_RS14050	COG3713	MltA-interacting MipA family protein
LP316_RS14055	COG1295	ribonuclease BN
LP316_RS14070	COG2234	aminopeptidase activity
LP316_RS14075	COG1648	precorrin-2 dehydrogenase activity
LP316_RS14075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LP316_RS14080	COG3610	response to peptide
LP316_RS14085	COG2966	Psort location CytoplasmicMembrane, score
LP316_RS14090	COG0513	Belongs to the DEAD box helicase family
LP316_RS14120	COG0789	Transcriptional regulator
LP316_RS14130	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LP316_RS14135	COG0848	biopolymer transport protein
LP316_RS14140	COG0811	peptide transport
LP316_RS14145	COG0811	peptide transport
LP316_RS14170	COG2204	response regulator
LP316_RS14185	COG4191	Histidine kinase
LP316_RS14185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LP316_RS14205	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LP316_RS14215	COG2188	Transcriptional regulator
LP316_RS14240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LP316_RS14245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LP316_RS14250	COG1862	Preprotein translocase
LP316_RS14255	COG0343	queuine tRNA-ribosyltransferase activity
LP316_RS14260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LP316_RS14265	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LP316_RS14285	COG3706	GGDEF domain
LP316_RS14320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LP316_RS14350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LP316_RS14435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LP316_RS14450	COG0681	Belongs to the peptidase S26 family
LP316_RS14470	COG1074	ATP-dependent DNA helicase activity
LP316_RS14480	COG1404	Belongs to the peptidase S8 family
LP316_RS14485	COG0464	growth
LP316_RS14505	COG0629	single-stranded DNA binding
LP316_RS14525	COG0714	Associated with various cellular activities
LP316_RS14550	COG2003	Belongs to the UPF0758 family
LP316_RS14570	COG1162	GTPase activity
LP316_RS14580	COG4106	trans-aconitate 2-methyltransferase activity
LP316_RS14640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LP316_RS14645	COG0018	arginyl-trna synthetase
LP316_RS14650	COG0084	hydrolase, TatD family'
LP316_RS14665	COG0560	Phosphoserine phosphatase
LP316_RS14675	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LP316_RS14705	COG0166	Belongs to the GPI family
LP316_RS14725	COG2971	BadF BadG BcrA BcrD
LP316_RS14730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LP316_RS14735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LP316_RS14755	COG0646	methionine synthase
LP316_RS14755	COG1410	methionine synthase
LP316_RS14770	COG0826	peptidase U32
LP316_RS14775	COG3706	GGDEF domain
LP316_RS14790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LP316_RS14795	COG4948	Mandelate Racemase Muconate Lactonizing
LP316_RS14820	COG3590	peptidase
LP316_RS14840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LP316_RS14845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LP316_RS14850	COG0730	response to heat
LP316_RS14860	COG0494	nUDIX hydrolase
LP316_RS14865	COG3066	DNA modification
LP316_RS14880	COG0676	glucose-6-phosphate 1-epimerase activity
LP316_RS14900	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LP316_RS14910	COG3122	Protein conserved in bacteria
LP316_RS14920	COG2832	Protein of unknown function (DUF454)
LP316_RS14925	COG3956	TIGRFAM MazG family protein
LP316_RS14930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LP316_RS14940	COG3437	response regulator, receiver
LP316_RS14940	COG4999	Histidine kinase
LP316_RS14940	COG2205	protein histidine kinase activity
LP316_RS14940	COG3850	Histidine kinase
LP316_RS14955	COG3609	addiction module antidote protein, CC2985 family
LP316_RS14975	COG3706	GGDEF domain
LP316_RS14980	COG0736	holo-[acyl-carrier-protein] synthase activity
LP316_RS14985	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LP316_RS14990	COG1381	Involved in DNA repair and RecF pathway recombination
LP316_RS14995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LP316_RS15000	COG0571	ribonuclease III activity
LP316_RS15010	COG0481	GTPase activity
LP316_RS15030	COG1595	DNA-templated transcription, initiation
LP316_RS15035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LP316_RS15045	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LP316_RS15055	COG1047	Peptidyl-prolyl cis-trans
LP316_RS15060	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
LP316_RS15095	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LP316_RS15100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LP316_RS15115	COG4191	Histidine kinase
LP316_RS15115	COG0784	Response regulator, receiver
LP316_RS15125	COG0840	transmembrane signaling receptor activity
LP316_RS15145	COG3046	protein related to deoxyribodipyrimidine photolyase
LP316_RS15155	COG0415	Belongs to the DNA photolyase family
LP316_RS15160	COG0415	Belongs to the DNA photolyase family
LP316_RS15175	COG5002	protein histidine kinase activity
LP316_RS15175	COG3850	Histidine kinase
LP316_RS15180	COG0745	RESPONSE REGULATOR receiver
LP316_RS15205	COG0583	DNA-binding transcription factor activity
LP316_RS15210	COG2824	Alkylphosphonate utilization operon protein PhnA
LP316_RS15215	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LP316_RS15225	COG0583	DNA-binding transcription factor activity
LP316_RS15250	COG0583	DNA-binding transcription factor activity
LP316_RS15285	COG2239	Acts as a magnesium transporter
LP316_RS15310	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LP316_RS15310	COG3264	Mechanosensitive ion channel
LP316_RS15325	COG0189	ligase activity
LP316_RS15345	COG2217	Heavy metal translocating P-type atpase
LP316_RS15355	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LP316_RS15380	COG4774	siderophore transport
LP316_RS15420	COG1401	restriction endodeoxyribonuclease activity
LP316_RS15485	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LP316_RS15485	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LP316_RS15490	COG0509	glycine decarboxylation via glycine cleavage system
LP316_RS15495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LP316_RS15500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LP316_RS15505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LP316_RS15510	COG0006	proline dipeptidase activity
LP316_RS15515	COG3079	Belongs to the UPF0149 family
LP316_RS15520	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LP316_RS15545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LP316_RS15560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LP316_RS15565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LP316_RS15570	COG0189	ligase activity
LP316_RS15580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LP316_RS15590	COG0840	transmembrane signaling receptor activity
LP316_RS15615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LP316_RS15620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LP316_RS15625	COG0762	integral membrane protein
LP316_RS15635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LP316_RS15640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LP316_RS15645	COG0590	tRNA wobble adenosine to inosine editing
LP316_RS15655	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LP316_RS15660	COG0047	phosphoribosylformylglycinamidine synthase activity
LP316_RS15660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LP316_RS15665	COG0778	Nitroreductase
LP316_RS15680	COG0564	pseudouridine synthase activity
LP316_RS15685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LP316_RS15720	COG0339	signal peptide processing
LP316_RS15725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LP316_RS15730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LP316_RS15740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LP316_RS15745	COG0083	homoserine kinase activity
LP316_RS15755	COG3706	GGDEF domain
LP316_RS15775	COG3141	response to X-ray
LP316_RS15780	COG0405	Gamma-glutamyltransferase
LP316_RS15800	COG4269	membrane
LP316_RS15815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LP316_RS15820	COG1288	antiporter activity
LP316_RS15825	COG4206	TonB-dependent receptor
LP316_RS15835	COG5001	Diguanylate cyclase
LP316_RS15835	COG4251	negative regulation of phosphorylation
LP316_RS15835	COG3706	GGDEF domain
LP316_RS15835	COG2203	Gaf domain
LP316_RS15845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LP316_RS15850	COG0746	molybdenum cofactor guanylyltransferase activity
LP316_RS15855	COG0521	Mo-molybdopterin cofactor biosynthetic process
LP316_RS15860	COG0315	cyclic pyranopterin monophosphate synthase activity
LP316_RS15865	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LP316_RS15870	COG0314	molybdopterin synthase activity
LP316_RS15885	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LP316_RS15890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LP316_RS15905	COG0504	CTP synthase activity
LP316_RS15930	COG0023	Translation Initiation Factor
LP316_RS15935	COG0745	RESPONSE REGULATOR receiver