locus-tag	class	description
Tharo_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tharo_RS00050	COG2161	toxin-antitoxin pair type II binding
Tharo_RS00100	COG1451	nucleotide metabolic process
Tharo_RS00115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tharo_RS00115	COG1017	nitric oxide dioxygenase activity
Tharo_RS00120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tharo_RS00125	COG2814	Major facilitator Superfamily
Tharo_RS00135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Tharo_RS00155	COG3264	Mechanosensitive ion channel
Tharo_RS00155	COG1196	nuclear chromosome segregation
Tharo_RS00165	COG0679	Auxin Efflux Carrier
Tharo_RS00170	COG0114	fumarate hydratase activity
Tharo_RS00190	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Tharo_RS00215	COG2974	May be involved in recombination
Tharo_RS00240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tharo_RS00255	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Tharo_RS00260	COG0501	Belongs to the peptidase M48B family
Tharo_RS00265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tharo_RS00270	COG0242	peptide deformylase activity
Tharo_RS00280	COG0758	DNA mediated transformation
Tharo_RS00285	COG2922	Belongs to the Smg family
Tharo_RS00305	COG0783	Belongs to the Dps family
Tharo_RS00315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tharo_RS00320	COG3909	cytochrome
Tharo_RS00330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tharo_RS00345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tharo_RS00345	COG2111	Na H antiporter
Tharo_RS00350	COG1006	Multisubunit Na H antiporter MnhC subunit
Tharo_RS00355	COG0651	ATP synthesis coupled electron transport
Tharo_RS00360	COG1863	multisubunit Na H antiporter MnhE subunit
Tharo_RS00365	COG2212	antiporter activity
Tharo_RS00370	COG1320	monovalent cation:proton antiporter activity
Tharo_RS00375	COG0861	Integral membrane protein TerC family
Tharo_RS00380	COG1253	flavin adenine dinucleotide binding
Tharo_RS00390	COG3609	addiction module antidote protein, CC2985 family
Tharo_RS00400	COG1132	(ABC) transporter
Tharo_RS00405	COG0420	3'-5' exonuclease activity
Tharo_RS00435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tharo_RS00455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tharo_RS00485	COG0243	molybdopterin cofactor binding
Tharo_RS00490	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tharo_RS00495	COG1910	domain protein
Tharo_RS00500	COG1960	acyl-CoA dehydrogenase activity
Tharo_RS00505	COG1960	acyl-CoA dehydrogenase activity
Tharo_RS00515	COG0445	tRNA wobble uridine modification
Tharo_RS00520	COG0357	Ribosomal RNA small subunit methyltransferase G
Tharo_RS00525	COG1192	Involved in chromosome partitioning
Tharo_RS00530	COG1475	DNA binding
Tharo_RS00545	COG0356	it plays a direct role in the translocation of protons across the membrane
Tharo_RS00555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tharo_RS00560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tharo_RS00565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tharo_RS00570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tharo_RS00575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tharo_RS00580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tharo_RS00595	COG2226	methyltransferase
Tharo_RS00605	COG0745	RESPONSE REGULATOR receiver
Tharo_RS00620	COG0121	glutamine amidotransferase
Tharo_RS00625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tharo_RS00655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tharo_RS00660	COG0154	amidase activity
Tharo_RS00665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tharo_RS00670	COG1077	Cell shape determining protein MreB Mrl
Tharo_RS00680	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Tharo_RS00685	COG0768	penicillin binding
Tharo_RS00690	COG0772	Belongs to the SEDS family
Tharo_RS00700	COG1686	Belongs to the peptidase S11 family
Tharo_RS00710	COG2921	Belongs to the UPF0250 family
Tharo_RS00715	COG0321	lipoyl(octanoyl) transferase activity
Tharo_RS00720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Tharo_RS00730	COG0210	DNA helicase
Tharo_RS00825	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Tharo_RS00840	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tharo_RS00845	COG3246	L-lysine catabolic process to acetate
Tharo_RS00895	COG0243	molybdopterin cofactor binding
Tharo_RS00910	COG5012	cobalamin binding
Tharo_RS00940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tharo_RS00955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tharo_RS00965	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Tharo_RS00980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tharo_RS00980	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tharo_RS00980	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Tharo_RS00980	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tharo_RS01005	COG0028	Belongs to the TPP enzyme family
Tharo_RS01010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tharo_RS01015	COG5433	transposase activity
Tharo_RS01090	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tharo_RS01095	COG2336	PFAM SpoVT AbrB
Tharo_RS01120	COG4372	Transposase
Tharo_RS01185	COG1959	2 iron, 2 sulfur cluster binding
Tharo_RS01195	COG0583	DNA-binding transcription factor activity
Tharo_RS01210	COG0625	glutathione transferase activity
Tharo_RS01215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tharo_RS01225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tharo_RS01265	COG0194	GDP metabolic process
Tharo_RS01270	COG1758	RNA polymerase activity
Tharo_RS01275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tharo_RS01285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tharo_RS01285	COG1199	ATP-dependent helicase activity
Tharo_RS01295	COG3850	Histidine kinase
Tharo_RS01300	COG2197	response regulator
Tharo_RS01305	COG4133	protoheme IX ABC transporter activity
Tharo_RS01310	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tharo_RS01325	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Tharo_RS01335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tharo_RS01340	COG3088	subunit of a heme lyase
Tharo_RS01345	COG4235	cytochrome complex assembly
Tharo_RS01350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tharo_RS01435	COG3135	benzoate transporter
Tharo_RS01445	COG0505	Belongs to the CarA family
Tharo_RS01450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tharo_RS01455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tharo_RS01460	COG1595	DNA-templated transcription, initiation
Tharo_RS01480	COG4771	TonB-dependent receptor
Tharo_RS01490	COG2226	methyltransferase
Tharo_RS01500	COG0583	DNA-binding transcription factor activity
Tharo_RS01505	COG2003	Belongs to the UPF0758 family
Tharo_RS01580	COG4372	Transposase
Tharo_RS01610	COG4372	Transposase
Tharo_RS01625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tharo_RS01630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tharo_RS01635	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tharo_RS01635	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tharo_RS01660	COG1558	bacterial-type flagellum-dependent cell motility
Tharo_RS01670	COG1749	Flagellar hook protein flgE
Tharo_RS01675	COG4787	bacterial-type flagellum-dependent cell motility
Tharo_RS01680	COG4786	Flagellar basal body rod
Tharo_RS01685	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Tharo_RS01690	COG1706	bacterial-type flagellum-dependent cell motility
Tharo_RS01700	COG1256	bacterial-type flagellum assembly
Tharo_RS01715	COG1987	bacterial-type flagellum assembly
Tharo_RS01720	COG1338	Plays a role in the flagellum-specific transport system
Tharo_RS01730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tharo_RS01765	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tharo_RS01780	COG1334	flagellar protein FlaG
Tharo_RS01785	COG0840	transmembrane signaling receptor activity
Tharo_RS01795	COG1487	ribonuclease activity
Tharo_RS01840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tharo_RS01840	COG4797	methyltransferase
Tharo_RS01855	COG3657	addiction module killer protein
Tharo_RS01860	COG4372	Transposase
Tharo_RS01950	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Tharo_RS01970	COG2257	FlhB HrpN YscU SpaS Family
Tharo_RS01990	COG1360	Flagellar Motor Protein
Tharo_RS01995	COG0643	Histidine kinase
Tharo_RS01995	COG2198	Histidine kinase
Tharo_RS02000	COG0835	chemotaxis
Tharo_RS02005	COG0840	transmembrane signaling receptor activity
Tharo_RS02010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tharo_RS02015	COG2201	protein-glutamate methylesterase activity
Tharo_RS02020	COG0745	RESPONSE REGULATOR receiver
Tharo_RS02035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tharo_RS02055	COG1191	sigma factor activity
Tharo_RS02060	COG0488	(ABC) transporter
Tharo_RS02065	COG2203	Gaf domain
Tharo_RS02065	COG5001	Diguanylate cyclase
Tharo_RS02065	COG4251	negative regulation of phosphorylation
Tharo_RS02065	COG3706	GGDEF domain
Tharo_RS02070	COG0625	glutathione transferase activity
Tharo_RS02090	COG0582	viral genome integration into host DNA
Tharo_RS02145	COG1525	nuclease
Tharo_RS02195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tharo_RS02200	COG0393	Putative heavy-metal-binding
Tharo_RS02205	COG0697	spore germination
Tharo_RS02210	COG0217	transcriptional regulatory protein
Tharo_RS02215	COG0433	COG0433 Predicted ATPase
Tharo_RS02220	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Tharo_RS02225	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Tharo_RS02230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tharo_RS02235	COG0688	phosphatidylethanolamine metabolic process
Tharo_RS02240	COG0840	transmembrane signaling receptor activity
Tharo_RS02245	COG0513	Belongs to the DEAD box helicase family
Tharo_RS02255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tharo_RS02265	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Tharo_RS02270	COG1492	cobalamin metabolic process
Tharo_RS02275	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tharo_RS02275	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tharo_RS02280	COG4654	Cytochrome c, class I
Tharo_RS02285	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Tharo_RS02300	COG1981	membrane
Tharo_RS02305	COG1763	Mo-molybdopterin cofactor biosynthetic process
Tharo_RS02310	COG0746	molybdenum cofactor guanylyltransferase activity
Tharo_RS02315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tharo_RS02345	COG3383	formate dehydrogenase (NAD+) activity
Tharo_RS02345	COG0243	molybdopterin cofactor binding
Tharo_RS02350	COG0437	4 iron, 4 sulfur cluster binding
Tharo_RS02390	COG0762	integral membrane protein
Tharo_RS02405	COG0540	Belongs to the ATCase OTCase family
Tharo_RS02410	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tharo_RS02415	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tharo_RS02420	COG1678	Uncharacterized ACR, COG1678
Tharo_RS02425	COG0415	Belongs to the DNA photolyase family
Tharo_RS02430	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Tharo_RS02445	COG0352	thiamine-phosphate diphosphorylase activity
Tharo_RS02450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tharo_RS02455	COG2239	Acts as a magnesium transporter
Tharo_RS02460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tharo_RS02465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tharo_RS02475	COG0557	exoribonuclease II activity
Tharo_RS02480	COG3150	esterase
Tharo_RS02485	COG1968	undecaprenyl-diphosphatase activity
Tharo_RS02490	COG1618	nucleotide phosphatase activity, acting on free nucleotides
Tharo_RS02490	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Tharo_RS02495	COG1643	Atp-dependent helicase
Tharo_RS02505	COG0360	Binds together with S18 to 16S ribosomal RNA
Tharo_RS02510	COG2965	DNA replication, synthesis of RNA primer
Tharo_RS02515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tharo_RS02520	COG0359	binds to the 23S rRNA
Tharo_RS02525	COG0305	Participates in initiation and elongation during chromosome replication
Tharo_RS02555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tharo_RS02560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tharo_RS02565	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Tharo_RS02575	COG0494	nUDIX hydrolase
Tharo_RS02580	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Tharo_RS02585	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Tharo_RS02590	COG0237	dephospho-CoA kinase activity
Tharo_RS02600	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Tharo_RS02605	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tharo_RS02620	COG3852	Histidine kinase
Tharo_RS02630	COG0174	glutamine synthetase
Tharo_RS02635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tharo_RS02645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tharo_RS02650	COG3568	Endonuclease Exonuclease Phosphatase
Tharo_RS02660	COG1832	CoA-binding protein
Tharo_RS02665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tharo_RS02670	COG3245	cytochrome
Tharo_RS02720	COG4263	nitrous-oxide reductase activity
Tharo_RS02730	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Tharo_RS02735	COG3706	GGDEF domain
Tharo_RS02740	COG0012	GTP binding
Tharo_RS02745	COG0193	aminoacyl-tRNA hydrolase activity
Tharo_RS02750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tharo_RS02755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tharo_RS02765	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tharo_RS02770	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Tharo_RS02780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tharo_RS02785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tharo_RS02790	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tharo_RS02795	COG0742	ribosomal rna small subunit methyltransferase
Tharo_RS02800	COG0612	Peptidase, M16
Tharo_RS02805	COG0612	Peptidase, M16
Tharo_RS02815	COG2884	Cell division ATP-binding protein ftsE
Tharo_RS02820	COG2177	Part of the ABC transporter FtsEX involved in
Tharo_RS02825	COG0450	alkyl hydroperoxide reductase
Tharo_RS02830	COG3634	alkyl hydroperoxide reductase activity
Tharo_RS02835	COG1132	(ABC) transporter
Tharo_RS02870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tharo_RS02875	COG0582	viral genome integration into host DNA
Tharo_RS02955	COG0515	serine threonine protein kinase
Tharo_RS02965	COG4245	von Willebrand factor, type A
Tharo_RS02970	COG2204	response regulator
Tharo_RS03010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tharo_RS03015	COG1702	phosphate starvation-inducible protein PhoH
Tharo_RS03020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tharo_RS03030	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Tharo_RS03035	COG0752	glycyl-tRNA synthetase alpha subunit
Tharo_RS03040	COG0751	glycine-tRNA ligase activity
Tharo_RS03045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Tharo_RS03050	COG0204	Acyl-transferase
Tharo_RS03065	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Tharo_RS03105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Tharo_RS03115	COG1127	ABC transporter
Tharo_RS03120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tharo_RS03125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Tharo_RS03145	COG1131	(ABC) transporter
Tharo_RS03150	COG0842	Transport permease protein
Tharo_RS03160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tharo_RS03165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tharo_RS03170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tharo_RS03175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tharo_RS03180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tharo_RS03185	COG0131	Imidazoleglycerol-phosphate dehydratase
Tharo_RS03190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tharo_RS03195	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Tharo_RS03200	COG0107	imidazoleglycerol-phosphate synthase activity
Tharo_RS03205	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tharo_RS03210	COG0140	phosphoribosyl-ATP diphosphatase activity
Tharo_RS03220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tharo_RS03225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tharo_RS03230	COG0805	protein transport
Tharo_RS03240	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Tharo_RS03255	COG0045	succinate-CoA ligase (ADP-forming) activity
Tharo_RS03260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tharo_RS03265	COG1716	ATPase activity
Tharo_RS03275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Tharo_RS03280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tharo_RS03285	COG0546	phosphoglycolate phosphatase activity
Tharo_RS03295	COG0582	viral genome integration into host DNA
Tharo_RS03305	COG1396	sequence-specific DNA binding
Tharo_RS03310	COG0583	DNA-binding transcription factor activity
Tharo_RS03315	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Tharo_RS03320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tharo_RS03340	COG0589	response to stress
Tharo_RS03345	COG3243	poly(R)-hydroxyalkanoic acid synthase
Tharo_RS03350	COG0786	glutamate:sodium symporter activity
Tharo_RS03355	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tharo_RS03365	COG0280	phosphate acetyltransferase
Tharo_RS03375	COG1028	Short-chain dehydrogenase reductase Sdr
Tharo_RS03385	COG0842	Transport permease protein
Tharo_RS03390	COG0842	Transport permease protein
Tharo_RS03390	COG1129	ABC transporter
Tharo_RS03395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tharo_RS03480	COG2003	Belongs to the UPF0758 family
Tharo_RS03570	COG1074	ATP-dependent DNA helicase activity
Tharo_RS03575	COG3593	DNA synthesis involved in DNA repair
Tharo_RS03665	COG0270	DNA (cytosine-5-)-methyltransferase activity
Tharo_RS03670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tharo_RS03675	COG0629	single-stranded DNA binding
Tharo_RS03725	COG0512	Glutamine amidotransferase of anthranilate synthase
Tharo_RS03730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tharo_RS03735	COG0134	indole-3-glycerol-phosphate synthase activity
Tharo_RS03745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tharo_RS03770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tharo_RS03775	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Tharo_RS03805	COG0109	protoheme IX farnesyltransferase activity
Tharo_RS03810	COG1999	signal sequence binding
Tharo_RS03865	COG1028	Short-chain dehydrogenase reductase Sdr
Tharo_RS03870	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Tharo_RS03900	COG2119	membrane
Tharo_RS03910	COG2895	sulfate adenylyltransferase (ATP) activity
Tharo_RS03915	COG0175	sulfate reduction
Tharo_RS03920	COG0175	sulfate reduction
Tharo_RS03935	COG0730	response to heat
Tharo_RS03940	COG0583	DNA-binding transcription factor activity
Tharo_RS03945	COG0252	asparaginase activity
Tharo_RS03955	COG5265	(ABC) transporter
Tharo_RS03965	COG1960	acyl-CoA dehydrogenase activity
Tharo_RS03970	COG1607	acyl-coa hydrolase
Tharo_RS03975	COG1024	Enoyl-CoA hydratase
Tharo_RS03975	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tharo_RS03980	COG0183	Belongs to the thiolase family
Tharo_RS03990	COG1805	sodium ion transport
Tharo_RS04025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tharo_RS04040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Tharo_RS04075	COG0284	orotidine-5'-phosphate decarboxylase activity
Tharo_RS04080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Tharo_RS04110	COG1965	Belongs to the frataxin family
Tharo_RS04145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tharo_RS04150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tharo_RS04155	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tharo_RS04160	COG0069	glutamate synthase activity
Tharo_RS04160	COG0070	glutamate synthase
Tharo_RS04160	COG0067	glutamate synthase
Tharo_RS04170	COG0679	Auxin Efflux Carrier
Tharo_RS04175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tharo_RS04195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tharo_RS04210	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Tharo_RS04220	COG2030	dehydratase
Tharo_RS04225	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tharo_RS04250	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Tharo_RS04270	COG0463	Glycosyl transferase, family 2
Tharo_RS04295	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Tharo_RS04310	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Tharo_RS04340	COG1414	Transcriptional regulator
Tharo_RS04345	COG2111	Na H antiporter
Tharo_RS04345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tharo_RS04350	COG1006	Multisubunit Na H antiporter MnhC subunit
Tharo_RS04355	COG0651	ATP synthesis coupled electron transport
Tharo_RS04360	COG1863	multisubunit Na H antiporter MnhE subunit
Tharo_RS04365	COG2212	antiporter activity
Tharo_RS04370	COG1320	monovalent cation:proton antiporter activity
Tharo_RS04385	COG1187	pseudouridine synthase activity
Tharo_RS04395	COG1136	(ABC) transporter
Tharo_RS04395	COG0577	efflux transmembrane transporter activity
Tharo_RS04400	COG0577	efflux transmembrane transporter activity
Tharo_RS04400	COG1136	(ABC) transporter
Tharo_RS04405	COG0577	efflux transmembrane transporter activity
Tharo_RS04405	COG1136	(ABC) transporter
Tharo_RS04410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tharo_RS04415	COG1715	Restriction endonuclease
Tharo_RS04430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tharo_RS04435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tharo_RS04445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tharo_RS04455	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
Tharo_RS04460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Tharo_RS04465	COG0351	phosphomethylpyrimidine kinase
Tharo_RS04470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tharo_RS04490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Tharo_RS04505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tharo_RS04520	COG2264	protein methyltransferase activity
Tharo_RS04525	COG0439	Biotin carboxylase
Tharo_RS04530	COG0511	ligase activity, forming carbon-carbon bonds
Tharo_RS04535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tharo_RS04545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tharo_RS04555	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tharo_RS04560	COG0792	nuclease activity
Tharo_RS04570	COG0418	dihydroorotase activity
Tharo_RS04575	COG0840	transmembrane signaling receptor activity
Tharo_RS04585	COG2001	Belongs to the MraZ family
Tharo_RS04590	COG0275	rRNA processing
Tharo_RS04595	COG3116	cell division
Tharo_RS04605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tharo_RS04610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tharo_RS04615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tharo_RS04620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Tharo_RS04625	COG0772	Belongs to the SEDS family
Tharo_RS04630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tharo_RS04635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tharo_RS04640	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tharo_RS04645	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Tharo_RS04655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tharo_RS04660	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Tharo_RS04695	COG0438	transferase activity, transferring glycosyl groups
Tharo_RS04705	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Tharo_RS04715	COG1696	Membrane protein involved in D-alanine export
Tharo_RS04730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tharo_RS04735	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Tharo_RS04815	COG4115	mRNA cleavage
Tharo_RS04855	COG0653	protein targeting
Tharo_RS04860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tharo_RS04875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tharo_RS04880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tharo_RS04885	COG1862	Preprotein translocase
Tharo_RS04890	COG0343	queuine tRNA-ribosyltransferase activity
Tharo_RS04895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tharo_RS04910	COG3550	peptidyl-serine autophosphorylation
Tharo_RS04920	COG0583	DNA-binding transcription factor activity
Tharo_RS04930	COG0670	Belongs to the BI1 family
Tharo_RS04935	COG0825	malonyl-CoA metabolic process
Tharo_RS04940	COG0037	tRNA processing
Tharo_RS04970	COG0586	Pfam SNARE associated Golgi protein
Tharo_RS04975	COG0105	UTP biosynthetic process
Tharo_RS04980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tharo_RS04995	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tharo_RS05000	COG0124	histidyl-tRNA synthetase
Tharo_RS05010	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tharo_RS05015	COG1160	GTP binding
Tharo_RS05020	COG1923	regulation of RNA biosynthetic process
Tharo_RS05025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tharo_RS05030	COG0330	HflC and HflK could
Tharo_RS05035	COG0330	HflC and HflK could
Tharo_RS05045	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Tharo_RS05050	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tharo_RS05065	COG0557	exoribonuclease II activity
Tharo_RS05070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tharo_RS05075	COG0778	Nitroreductase
Tharo_RS05080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tharo_RS05090	COG2223	nitrite transmembrane transporter activity
Tharo_RS05095	COG2815	serine threonine protein kinase
Tharo_RS05095	COG0515	serine threonine protein kinase
Tharo_RS05100	COG0243	molybdopterin cofactor binding
Tharo_RS05150	COG0471	metal ion transport
Tharo_RS05150	COG3273	potassium ion transport
Tharo_RS05155	COG0778	Nitroreductase
Tharo_RS05170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tharo_RS05175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tharo_RS05180	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tharo_RS05185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tharo_RS05190	COG0723	plastoquinol--plastocyanin reductase activity
Tharo_RS05195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Tharo_RS05200	COG2857	Cytochrome c1
Tharo_RS05205	COG0625	glutathione transferase activity
Tharo_RS05210	COG2969	positive regulation of protein catabolic process
Tharo_RS05220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tharo_RS05225	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Tharo_RS05240	COG1335	isochorismatase
Tharo_RS05245	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tharo_RS05255	COG1902	pentaerythritol trinitrate reductase activity
Tharo_RS05265	COG1067	ATP-dependent peptidase activity
Tharo_RS05270	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Tharo_RS05275	COG1984	allophanate hydrolase subunit 2
Tharo_RS05285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tharo_RS05290	COG0459	protein refolding
Tharo_RS05300	COG0642	Histidine kinase
Tharo_RS05315	COG2026	Addiction module toxin, RelE StbE family
Tharo_RS05320	COG2814	Major facilitator Superfamily
Tharo_RS05325	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tharo_RS05330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tharo_RS05335	COG2890	protein-(glutamine-N5) methyltransferase activity
Tharo_RS05340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tharo_RS05355	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Tharo_RS05370	COG4536	flavin adenine dinucleotide binding
Tharo_RS05380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tharo_RS05410	COG2070	2-Nitropropane dioxygenase
Tharo_RS05420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tharo_RS05425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tharo_RS05435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tharo_RS05450	COG1238	metal cluster binding
Tharo_RS05455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tharo_RS05460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Tharo_RS05470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tharo_RS05470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tharo_RS05480	COG0720	synthase
Tharo_RS05495	COG0527	aspartate kinase activity
Tharo_RS05555	COG2159	amidohydrolase
Tharo_RS05585	COG0667	Aldo Keto reductase
Tharo_RS05590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tharo_RS05625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tharo_RS05655	COG0318	PFAM AMP-dependent synthetase and ligase
Tharo_RS05660	COG1024	Enoyl-CoA hydratase
Tharo_RS05665	COG0183	Belongs to the thiolase family
Tharo_RS05675	COG1960	acyl-CoA dehydrogenase activity
Tharo_RS05680	COG0367	asparagine synthase
Tharo_RS05685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tharo_RS05685	COG0189	ligase activity
Tharo_RS05690	COG1363	Peptidase, m42
Tharo_RS05715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tharo_RS05765	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tharo_RS05770	COG4177	L-phenylalanine transmembrane transporter activity
Tharo_RS05795	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tharo_RS05805	COG3383	formate dehydrogenase (NAD+) activity
Tharo_RS05810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Tharo_RS05815	COG2814	Major facilitator Superfamily
Tharo_RS05825	COG0564	pseudouridine synthase activity
Tharo_RS05840	COG3243	poly(R)-hydroxyalkanoic acid synthase
Tharo_RS05845	COG1028	Short-chain dehydrogenase reductase Sdr
Tharo_RS05860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tharo_RS05865	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tharo_RS05870	COG0277	FAD linked oxidase domain protein
Tharo_RS05905	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tharo_RS05910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tharo_RS05930	COG0318	PFAM AMP-dependent synthetase and ligase
Tharo_RS05935	COG0028	Belongs to the TPP enzyme family
Tharo_RS05940	COG0440	acetolactate synthase activity
Tharo_RS05945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tharo_RS05950	COG2814	Major facilitator Superfamily
Tharo_RS05955	COG0501	Belongs to the peptidase M48B family
Tharo_RS05960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tharo_RS05970	COG0066	3-isopropylmalate dehydratase activity
Tharo_RS05975	COG0473	3-isopropylmalate dehydrogenase activity
Tharo_RS05995	COG0101	tRNA pseudouridine synthase activity
Tharo_RS06000	COG0135	phosphoribosylanthranilate isomerase activity
Tharo_RS06005	COG0133	tryptophan synthase activity
Tharo_RS06010	COG0159	tryptophan synthase activity
Tharo_RS06015	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Tharo_RS06020	COG0285	dihydrofolate synthase activity
Tharo_RS06045	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tharo_RS06050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tharo_RS06055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tharo_RS06060	COG0215	cysteine-tRNA ligase activity
Tharo_RS06070	COG0484	heat shock protein binding
Tharo_RS06075	COG0443	Heat shock 70 kDa protein
Tharo_RS06080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tharo_RS06090	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Tharo_RS06100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tharo_RS06105	COG0287	Prephenate dehydrogenase
Tharo_RS06110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tharo_RS06120	COG0776	regulation of translation
Tharo_RS06130	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Tharo_RS06160	COG2261	transglycosylase associated protein
Tharo_RS06170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tharo_RS06175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tharo_RS06180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tharo_RS06185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tharo_RS06190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tharo_RS06195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tharo_RS06195	COG0072	phenylalanine-tRNA ligase activity
Tharo_RS06200	COG0776	regulation of translation
Tharo_RS06215	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tharo_RS06220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tharo_RS06240	COG2951	lytic endotransglycosylase activity
Tharo_RS06245	COG0123	including yeast histone deacetylase and acetoin utilization protein
Tharo_RS06250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tharo_RS06255	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Tharo_RS06265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tharo_RS06305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tharo_RS06315	COG0011	TIGRFAM Protein of
Tharo_RS06335	COG1012	belongs to the aldehyde dehydrogenase family
Tharo_RS06340	COG1024	Enoyl-CoA hydratase
Tharo_RS06355	COG3396	Phenylacetate-CoA oxygenase
Tharo_RS06360	COG3460	Phenylacetate-CoA oxygenase
Tharo_RS06365	COG3396	Phenylacetate-CoA oxygenase
Tharo_RS06370	COG2151	metal-sulfur cluster biosynthetic enzyme
Tharo_RS06375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tharo_RS06380	COG1309	transcriptional regulator
Tharo_RS06385	COG0183	Belongs to the thiolase family
Tharo_RS06390	COG0789	Transcriptional regulator
Tharo_RS06405	COG4659	FMN binding
Tharo_RS06410	COG4658	electron transport chain
Tharo_RS06415	COG4656	Part of a membrane complex involved in electron transport
Tharo_RS06420	COG2878	Part of a membrane complex involved in electron transport
Tharo_RS06425	COG4657	Part of a membrane complex involved in electron transport
Tharo_RS06440	COG0826	peptidase U32
Tharo_RS06540	COG0437	4 iron, 4 sulfur cluster binding
Tharo_RS06545	COG0243	molybdopterin cofactor binding
Tharo_RS06550	COG0517	IMP dehydrogenase activity
Tharo_RS06560	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tharo_RS06565	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tharo_RS06565	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tharo_RS06605	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tharo_RS06685	COG2902	Dehydrogenase
Tharo_RS06690	COG0504	CTP synthase activity
Tharo_RS06695	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Tharo_RS06700	COG0148	phosphopyruvate hydratase activity
Tharo_RS06705	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Tharo_RS06710	COG0791	NLP P60 protein
Tharo_RS06725	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Tharo_RS06730	COG0306	phosphate transporter
Tharo_RS06740	COG0302	gtp cyclohydrolase
Tharo_RS06750	COG4681	YaeQ
Tharo_RS06765	COG1278	Cold shock
Tharo_RS06770	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Tharo_RS06775	COG0613	PHP domain protein
Tharo_RS06780	COG0009	L-threonylcarbamoyladenylate synthase
Tharo_RS06785	COG1994	Peptidase M50
Tharo_RS06790	COG0180	Tryptophanyl-tRNA synthetase
Tharo_RS06795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Tharo_RS06800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tharo_RS06805	COG1187	pseudouridine synthase activity
Tharo_RS06810	COG0779	Required for maturation of 30S ribosomal subunits
Tharo_RS06815	COG2251	uridine kinase activity
Tharo_RS06815	COG0195	Participates in both transcription termination and antitermination
Tharo_RS06820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tharo_RS06825	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tharo_RS06830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tharo_RS06835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tharo_RS06840	COG1185	polyribonucleotide nucleotidyltransferase activity
Tharo_RS06845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tharo_RS06910	COG0822	iron-sulfur transferase activity
Tharo_RS06915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tharo_RS06920	COG0719	Fe-S assembly protein
Tharo_RS06925	COG0396	ATPase activity
Tharo_RS06930	COG0719	Fe-S assembly protein
Tharo_RS06955	COG4251	negative regulation of phosphorylation
Tharo_RS06960	COG0625	glutathione transferase activity
Tharo_RS06965	COG1487	ribonuclease activity
Tharo_RS06970	COG4691	Plasmid stability protein
Tharo_RS06995	COG2363	Small membrane protein
Tharo_RS07025	COG3158	transport of potassium into the cell
Tharo_RS07030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tharo_RS07040	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Tharo_RS07040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tharo_RS07045	COG2354	Protein conserved in bacteria
Tharo_RS07050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tharo_RS07055	COG1196	nuclear chromosome segregation
Tharo_RS07060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tharo_RS07090	COG2188	Transcriptional regulator
Tharo_RS07105	COG3314	Sporulation integral membrane protein YlbJ
Tharo_RS07110	COG0010	Belongs to the arginase family
Tharo_RS07115	COG1228	amidohydrolase
Tharo_RS07135	COG3047	cAMP biosynthetic process
Tharo_RS07160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tharo_RS07175	COG0348	domain, Protein
Tharo_RS07180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tharo_RS07205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tharo_RS07235	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Tharo_RS07240	COG1140	nitrate reductase beta subunit
Tharo_RS07245	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Tharo_RS07250	COG2181	nitrate reductase activity
Tharo_RS07255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tharo_RS07270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tharo_RS07275	COG0826	peptidase U32
Tharo_RS07280	COG0826	peptidase U32
Tharo_RS07310	COG4263	nitrous-oxide reductase activity
Tharo_RS07315	COG1032	radical SAM domain protein
Tharo_RS07335	COG1136	(ABC) transporter
Tharo_RS07355	COG0501	Belongs to the peptidase M48B family
Tharo_RS07360	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Tharo_RS07370	COG0254	rRNA binding
Tharo_RS07385	COG3012	SEC-C Motif Domain Protein
Tharo_RS07385	COG3318	Belongs to the UPF0149 family
Tharo_RS07395	COG0727	PFAM Uncharacterised protein family (UPF0153)
Tharo_RS07405	COG2501	S4 domain
Tharo_RS07425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Tharo_RS07460	COG0039	L-malate dehydrogenase activity
Tharo_RS07465	COG2188	Transcriptional regulator
Tharo_RS07480	COG1053	succinate dehydrogenase
Tharo_RS07485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Tharo_RS07490	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Tharo_RS07495	COG0372	Belongs to the citrate synthase family
Tharo_RS07500	COG0567	Dehydrogenase, E1 component
Tharo_RS07505	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tharo_RS07510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tharo_RS07515	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Tharo_RS07520	COG1199	ATP-dependent helicase activity
Tharo_RS07525	COG1763	Mo-molybdopterin cofactor biosynthetic process
Tharo_RS07530	COG0303	'Molybdopterin
Tharo_RS07535	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Tharo_RS07540	COG0314	molybdopterin synthase activity
Tharo_RS07570	COG0657	acetylesterase activity
Tharo_RS07580	COG1376	ErfK ybiS ycfS ynhG family protein
Tharo_RS07590	COG0354	folic acid binding
Tharo_RS07595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tharo_RS07600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tharo_RS07615	COG0084	hydrolase, TatD family'
Tharo_RS07630	COG2207	Transcriptional regulator
Tharo_RS07635	COG2807	transmembrane transport
Tharo_RS07670	COG2824	Alkylphosphonate utilization operon protein PhnA
Tharo_RS07675	COG1473	amidohydrolase
Tharo_RS07680	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Tharo_RS07700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tharo_RS07705	COG1067	ATP-dependent peptidase activity
Tharo_RS07715	COG3647	Membrane
Tharo_RS07725	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Tharo_RS07760	COG3409	Peptidoglycan-binding domain 1 protein
Tharo_RS07760	COG3267	Type II secretory pathway component ExeA
Tharo_RS07820	COG2151	metal-sulfur cluster biosynthetic enzyme
Tharo_RS07825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tharo_RS07835	COG0318	PFAM AMP-dependent synthetase and ligase
Tharo_RS07845	COG0071	Belongs to the small heat shock protein (HSP20) family
Tharo_RS07860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Tharo_RS07865	COG0165	Argininosuccinate lyase
Tharo_RS07870	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Tharo_RS07875	COG0181	hydroxymethylbilane synthase activity
Tharo_RS07885	COG2959	enzyme of heme biosynthesis
Tharo_RS07895	COG0408	coproporphyrinogen oxidase activity
Tharo_RS07900	COG3422	double-strand break repair
Tharo_RS07905	COG0151	Belongs to the GarS family
Tharo_RS07910	COG0138	bifunctional purine biosynthesis protein purh
Tharo_RS07915	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Tharo_RS07925	COG0659	secondary active sulfate transmembrane transporter activity
Tharo_RS07930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tharo_RS07930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tharo_RS07940	COG0489	protein tyrosine kinase activity
Tharo_RS07945	COG0717	Belongs to the dCTP deaminase family
Tharo_RS07960	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Tharo_RS08015	COG3267	Type II secretory pathway component ExeA
Tharo_RS08015	COG3409	Peptidoglycan-binding domain 1 protein
Tharo_RS08040	COG0556	nucleotide-excision repair
Tharo_RS08045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tharo_RS08050	COG1530	ribonuclease E activity
Tharo_RS08060	COG0564	pseudouridine synthase activity
Tharo_RS08070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tharo_RS08075	COG0424	maF-like protein
Tharo_RS08085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tharo_RS08090	COG0416	fatty acid biosynthetic process
Tharo_RS08095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tharo_RS08100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Tharo_RS08110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tharo_RS08115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tharo_RS08125	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tharo_RS08150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tharo_RS08160	COG0481	GTPase activity
Tharo_RS08165	COG0681	Belongs to the peptidase S26 family
Tharo_RS08175	COG0571	ribonuclease III activity
Tharo_RS08180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tharo_RS08185	COG1381	Involved in DNA repair and RecF pathway recombination
Tharo_RS08190	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Tharo_RS08195	COG0736	holo-[acyl-carrier-protein] synthase activity
Tharo_RS08200	COG1472	Belongs to the glycosyl hydrolase 3 family
Tharo_RS08205	COG0322	excinuclease ABC activity
Tharo_RS08225	COG0501	Belongs to the peptidase M48B family
Tharo_RS08230	COG1704	LemA family
Tharo_RS08235	COG1242	4 iron, 4 sulfur cluster binding
Tharo_RS08290	COG2816	NAD+ diphosphatase activity
Tharo_RS08300	COG4771	TonB-dependent receptor
Tharo_RS08345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Tharo_RS08350	COG1469	GTP cyclohydrolase I activity
Tharo_RS08355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tharo_RS08360	COG0142	geranyltranstransferase activity
Tharo_RS08365	COG1722	exodeoxyribonuclease VII activity
Tharo_RS08375	COG3411	Ferredoxin
Tharo_RS08380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tharo_RS08385	COG1047	Peptidyl-prolyl cis-trans
Tharo_RS08390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tharo_RS08395	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tharo_RS08400	COG0196	riboflavin kinase activity
Tharo_RS08405	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tharo_RS08410	COG0802	atpase or kinase
Tharo_RS08415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tharo_RS08420	COG2900	Belongs to the SlyX family
Tharo_RS08425	COG3045	CreA protein
Tharo_RS08430	COG3033	Beta-eliminating lyase
Tharo_RS08440	COG0826	peptidase U32
Tharo_RS08450	COG2133	pyrroloquinoline quinone binding
Tharo_RS08460	COG3108	Peptidase M15
Tharo_RS08465	COG2989	Protein conserved in bacteria
Tharo_RS08485	COG2204	response regulator
Tharo_RS08500	COG0697	spore germination
Tharo_RS08505	COG0488	(ABC) transporter
Tharo_RS08515	COG0583	DNA-binding transcription factor activity
Tharo_RS08525	COG0268	Binds directly to 16S ribosomal RNA
Tharo_RS08535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tharo_RS08540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tharo_RS08545	COG0137	argininosuccinate synthase activity
Tharo_RS08555	COG3123	guanosine phosphorylase activity
Tharo_RS08560	COG1666	GTP binding
Tharo_RS08595	COG0494	nUDIX hydrolase
Tharo_RS08605	COG0183	Belongs to the thiolase family
Tharo_RS08610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tharo_RS08620	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Tharo_RS08640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tharo_RS08650	COG5002	protein histidine kinase activity
Tharo_RS08655	COG0745	RESPONSE REGULATOR receiver
Tharo_RS08660	COG5002	protein histidine kinase activity
Tharo_RS08660	COG2176	DNA-directed DNA polymerase activity
Tharo_RS08665	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tharo_RS08675	COG0542	response to heat
Tharo_RS08680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tharo_RS08695	COG0601	transmembrane transport
Tharo_RS08700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tharo_RS08705	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Tharo_RS08725	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Tharo_RS08730	COG1140	nitrate reductase beta subunit
Tharo_RS08735	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Tharo_RS08740	COG2181	nitrate reductase activity
Tharo_RS08745	COG3850	Histidine kinase
Tharo_RS08750	COG2197	response regulator
Tharo_RS08765	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tharo_RS08775	COG2914	Belongs to the UPF0125 (RnfH) family
Tharo_RS08785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tharo_RS08785	COG0519	Catalyzes the synthesis of GMP from XMP
Tharo_RS08790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tharo_RS08805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tharo_RS08805	COG1648	precorrin-2 dehydrogenase activity
Tharo_RS08810	COG2010	Cytochrome c
Tharo_RS08840	COG1522	sequence-specific DNA binding
Tharo_RS08855	COG0535	radical SAM domain protein
Tharo_RS08885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tharo_RS08905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tharo_RS08915	COG2010	Cytochrome c
Tharo_RS08925	COG0167	dihydroorotate dehydrogenase activity
Tharo_RS08930	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Tharo_RS08935	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Tharo_RS08940	COG3842	ATPase activity
Tharo_RS08945	COG1178	ABC-type Fe3 transport system permease component
Tharo_RS08950	COG1840	ABC-type Fe3 transport system, periplasmic component
Tharo_RS08965	COG0791	NLP P60 protein
Tharo_RS08980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Tharo_RS08985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tharo_RS08995	COG0436	Aminotransferase
Tharo_RS09005	COG2258	MOSC domain
Tharo_RS09010	COG3360	Dodecin
Tharo_RS09020	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Tharo_RS09030	COG0850	regulation of cytokinetic process
Tharo_RS09035	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Tharo_RS09040	COG1393	Belongs to the ArsC family
Tharo_RS09045	COG2183	response to ionizing radiation
Tharo_RS09055	COG0045	succinate-CoA ligase (ADP-forming) activity
Tharo_RS09055	COG1042	CoA-binding domain protein
Tharo_RS09055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tharo_RS09065	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Tharo_RS09080	COG4181	ATPase activity
Tharo_RS09085	COG0560	Phosphoserine phosphatase
Tharo_RS09090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tharo_RS09115	COG0686	Belongs to the AlaDH PNT family
Tharo_RS09125	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Tharo_RS09185	COG0583	DNA-binding transcription factor activity
Tharo_RS09190	COG1960	acyl-CoA dehydrogenase activity
Tharo_RS09195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tharo_RS09210	COG3852	Histidine kinase
Tharo_RS09215	COG2204	response regulator
Tharo_RS09240	COG1137	ATPase activity
Tharo_RS09250	COG1454	alcohol dehydrogenase
Tharo_RS09260	COG1454	alcohol dehydrogenase
Tharo_RS09270	COG0579	oxidoreductase
Tharo_RS09275	COG2358	TRAP transporter, solute receptor (TAXI family
Tharo_RS09295	COG2204	response regulator
Tharo_RS09310	COG0584	glycerophosphoryl diester phosphodiesterase
Tharo_RS09340	COG0789	Transcriptional regulator
Tharo_RS09350	COG5002	protein histidine kinase activity
Tharo_RS09435	COG0045	succinate-CoA ligase (ADP-forming) activity
Tharo_RS09435	COG1042	CoA-binding domain protein
Tharo_RS09435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tharo_RS09445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tharo_RS09450	COG1024	Enoyl-CoA hydratase
Tharo_RS09460	COG1960	acyl-CoA dehydrogenase activity
Tharo_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
Tharo_RS09470	COG1024	Enoyl-CoA hydratase
Tharo_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
Tharo_RS09480	COG1024	Enoyl-CoA hydratase
Tharo_RS09485	COG1309	transcriptional regulator
Tharo_RS09490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tharo_RS09500	COG0402	S-adenosylhomocysteine deaminase activity
Tharo_RS09505	COG2815	serine threonine protein kinase
Tharo_RS09505	COG0515	serine threonine protein kinase
Tharo_RS09510	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Tharo_RS09515	COG1420	regulation of RNA biosynthetic process
Tharo_RS09520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tharo_RS09525	COG0497	DNA recombination
Tharo_RS09530	COG0735	belongs to the Fur family
Tharo_RS09540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tharo_RS09550	COG0505	Belongs to the CarA family
Tharo_RS09555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tharo_RS09560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tharo_RS09570	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Tharo_RS09575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tharo_RS09580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tharo_RS09585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tharo_RS09590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tharo_RS09595	COG0573	inorganic phosphate transmembrane transporter activity
Tharo_RS09605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tharo_RS09620	COG0798	PFAM Bile acid sodium symporter
Tharo_RS09635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tharo_RS09645	COG0149	triose-phosphate isomerase activity
Tharo_RS09660	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tharo_RS09665	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tharo_RS09670	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tharo_RS09675	COG0649	NAD binding
Tharo_RS09680	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Tharo_RS09690	COG1034	ATP synthesis coupled electron transport
Tharo_RS09695	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tharo_RS09700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tharo_RS09710	COG0713	ATP synthesis coupled electron transport
Tharo_RS09725	COG1007	ATP synthesis coupled electron transport
Tharo_RS09730	COG0494	nUDIX hydrolase
Tharo_RS09735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tharo_RS09735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tharo_RS09745	COG2840	Smr protein MutS2
Tharo_RS09750	COG0492	ferredoxin-NADP+ reductase activity
Tharo_RS09760	COG1674	ftsk spoiiie
Tharo_RS09765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Tharo_RS09770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tharo_RS09780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tharo_RS09785	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Tharo_RS09815	COG1487	ribonuclease activity
Tharo_RS09840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Tharo_RS09850	COG2078	PFAM AMMECR1 domain protein
Tharo_RS09855	COG1355	regulation of microtubule-based process
Tharo_RS09860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tharo_RS09865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tharo_RS09880	COG3228	Belongs to the MtfA family
Tharo_RS09885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tharo_RS09890	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Tharo_RS09895	COG0248	Ppx GppA phosphatase
Tharo_RS09900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tharo_RS09905	COG1127	ABC transporter
Tharo_RS09920	COG0318	PFAM AMP-dependent synthetase and ligase
Tharo_RS09930	COG0084	hydrolase, TatD family'
Tharo_RS09940	COG1960	acyl-CoA dehydrogenase activity
Tharo_RS09945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tharo_RS09955	COG2350	Protein conserved in bacteria
Tharo_RS09960	COG2917	probably involved in intracellular septation
Tharo_RS09980	COG1214	PFAM Peptidase M22, glycoprotease
Tharo_RS09985	COG0456	acetyltransferase
Tharo_RS09990	COG1573	uracil-dna glycosylase
Tharo_RS09995	COG0477	Major facilitator Superfamily
Tharo_RS10020	COG3259	Nickel-dependent hydrogenase
Tharo_RS10025	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
Tharo_RS10035	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tharo_RS10050	COG0628	permease
Tharo_RS10055	COG3162	membrane
Tharo_RS10075	COG3174	membrane
Tharo_RS10085	COG2814	Major facilitator Superfamily
Tharo_RS10095	COG5012	cobalamin binding
Tharo_RS10100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tharo_RS10160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Tharo_RS10170	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Tharo_RS10175	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Tharo_RS10180	COG3639	organic phosphonate transmembrane transporter activity
Tharo_RS10185	COG3639	organic phosphonate transmembrane transporter activity
Tharo_RS10195	COG3550	peptidyl-serine autophosphorylation
Tharo_RS10250	COG0577	efflux transmembrane transporter activity
Tharo_RS10250	COG1136	(ABC) transporter
Tharo_RS10255	COG1562	ergosterol biosynthetic process
Tharo_RS10260	COG1562	ergosterol biosynthetic process
Tharo_RS10265	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Tharo_RS10270	COG0210	DNA helicase
Tharo_RS10275	COG2866	Carboxypeptidase
Tharo_RS10280	COG3022	response to hydroperoxide
Tharo_RS10295	COG0156	8-amino-7-oxononanoate synthase activity
Tharo_RS10300	COG2267	carboxylic ester hydrolase activity
Tharo_RS10305	COG2226	methyltransferase
Tharo_RS10310	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Tharo_RS10340	COG1487	ribonuclease activity
Tharo_RS10365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tharo_RS10370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tharo_RS10375	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tharo_RS10380	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tharo_RS10385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tharo_RS10390	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tharo_RS10410	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tharo_RS10415	COG0575	Belongs to the CDS family
Tharo_RS10420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tharo_RS10425	COG0233	cytoplasmic translational termination
Tharo_RS10430	COG0528	UMP kinase activity
Tharo_RS10435	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tharo_RS10440	COG0052	Belongs to the universal ribosomal protein uS2 family
Tharo_RS10445	COG0024	Methionine aminopeptidase
Tharo_RS10450	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Tharo_RS10470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tharo_RS10480	COG1196	nuclear chromosome segregation
Tharo_RS10485	COG0436	Aminotransferase
Tharo_RS10490	COG2171	N-acyltransferase activity
Tharo_RS10500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tharo_RS10520	COG0443	Heat shock 70 kDa protein
Tharo_RS10525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Tharo_RS10535	COG0822	iron-sulfur transferase activity
Tharo_RS10540	COG1104	cysteine desulfurase activity
Tharo_RS10545	COG1104	cysteine desulfurase activity
Tharo_RS10555	COG1045	serine acetyltransferase
Tharo_RS10565	COG0483	inositol monophosphate 1-phosphatase activity
Tharo_RS10645	COG3772	lysozyme
Tharo_RS10730	COG3728	DNA packaging
Tharo_RS10730	COG5484	DNA packaging
Tharo_RS10760	COG3561	AntA/AntB antirepressor
Tharo_RS10850	COG2974	May be involved in recombination
Tharo_RS10855	COG0419	ATPase involved in DNA repair
Tharo_RS10930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tharo_RS10945	COG0517	IMP dehydrogenase activity
Tharo_RS10955	COG0328	RNA-DNA hybrid ribonuclease activity
Tharo_RS10960	COG2226	methyltransferase
Tharo_RS10965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tharo_RS10970	COG0741	lytic transglycosylase activity
Tharo_RS10970	COG1388	LysM domain
Tharo_RS10990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tharo_RS11055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tharo_RS11060	COG0509	glycine decarboxylation via glycine cleavage system
Tharo_RS11065	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tharo_RS11065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tharo_RS11090	COG0563	adenylate kinase activity
Tharo_RS11095	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Tharo_RS11100	COG2835	tetraacyldisaccharide 4'-kinase activity
Tharo_RS11105	COG1663	tetraacyldisaccharide 4'-kinase activity
Tharo_RS11110	COG0848	biopolymer transport protein
Tharo_RS11115	COG0811	peptide transport
Tharo_RS11120	COG1570	exodeoxyribonuclease VII activity
Tharo_RS11125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Tharo_RS11135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tharo_RS11150	COG2878	Part of a membrane complex involved in electron transport
Tharo_RS11155	COG4656	Part of a membrane complex involved in electron transport
Tharo_RS11175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tharo_RS11190	COG1280	lysine exporter protein (LysE YggA)
Tharo_RS11200	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Tharo_RS11205	COG2169	Transcriptional regulator
Tharo_RS11205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tharo_RS11210	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tharo_RS11225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tharo_RS11260	COG0326	Molecular chaperone. Has ATPase activity
Tharo_RS11295	COG1404	Belongs to the peptidase S8 family
Tharo_RS11340	COG4795	General secretion pathway protein
Tharo_RS11345	COG2165	general secretion pathway protein
Tharo_RS11355	COG2165	general secretion pathway protein
Tharo_RS11360	COG1459	type II secretion system
Tharo_RS11365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Tharo_RS11385	COG0840	transmembrane signaling receptor activity
Tharo_RS11395	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Tharo_RS11400	COG0840	transmembrane signaling receptor activity
Tharo_RS11405	COG4191	Histidine kinase
Tharo_RS11410	COG4566	intracellular signal transduction
Tharo_RS11430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Tharo_RS11450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tharo_RS11460	COG2154	pterin-4-alpha-carbinolamine dehydratase
Tharo_RS11465	COG0402	S-adenosylhomocysteine deaminase activity
Tharo_RS11470	COG2201	protein-glutamate methylesterase activity
Tharo_RS11475	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Tharo_RS11485	COG0835	chemotaxis
Tharo_RS11490	COG0840	transmembrane signaling receptor activity
Tharo_RS11495	COG0643	Histidine kinase
Tharo_RS11495	COG2198	Histidine kinase
Tharo_RS11520	COG4251	negative regulation of phosphorylation
Tharo_RS11535	COG3300	MHYT domain
Tharo_RS11535	COG5001	Diguanylate cyclase
Tharo_RS11540	COG3622	Belongs to the hyi family
Tharo_RS11545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Tharo_RS11555	COG2217	Heavy metal translocating P-type atpase
Tharo_RS11575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tharo_RS11580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tharo_RS11590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tharo_RS11595	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tharo_RS11620	COG2010	Cytochrome c
Tharo_RS11635	COG3278	Belongs to the heme-copper respiratory oxidase family
Tharo_RS11645	COG2217	Heavy metal translocating P-type atpase
Tharo_RS11665	COG1346	cytolysis
Tharo_RS11690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tharo_RS11710	COG1051	belongs to the nudix hydrolase family
Tharo_RS11715	COG0756	dUTP diphosphatase activity
Tharo_RS11720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tharo_RS11725	COG2003	Belongs to the UPF0758 family
Tharo_RS11730	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tharo_RS11735	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tharo_RS11740	COG1278	Cold shock
Tharo_RS11745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Tharo_RS11750	COG0542	response to heat
Tharo_RS11755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Tharo_RS11775	COG2205	protein histidine kinase activity
Tharo_RS11795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tharo_RS11800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tharo_RS11805	COG0739	heme binding
Tharo_RS11810	COG0316	Belongs to the HesB IscA family
Tharo_RS11815	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tharo_RS11820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tharo_RS11825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tharo_RS11830	COG1765	OsmC-like protein
Tharo_RS11835	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Tharo_RS11850	COG0247	lactate metabolic process
Tharo_RS11855	COG1592	Rubrerythrin
Tharo_RS11860	COG0494	nUDIX hydrolase
Tharo_RS11865	COG0442	prolyl-tRNA aminoacylation
Tharo_RS11870	COG0741	lytic transglycosylase activity
Tharo_RS11880	COG2204	response regulator
Tharo_RS11890	COG0312	modulator of DNA gyrase
Tharo_RS11895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tharo_RS11905	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Tharo_RS11930	COG0482	sulfurtransferase activity
Tharo_RS11975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tharo_RS11990	COG2096	Adenosyltransferase
Tharo_RS11995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tharo_RS12000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tharo_RS12005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Tharo_RS12010	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Tharo_RS12020	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tharo_RS12025	COG3028	Belongs to the UPF0307 family
Tharo_RS12030	COG0312	modulator of DNA gyrase
Tharo_RS12035	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tharo_RS12045	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tharo_RS12060	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tharo_RS12065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tharo_RS12070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tharo_RS12070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tharo_RS12075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tharo_RS12085	COG0793	Belongs to the peptidase S41A family
Tharo_RS12095	COG0640	Transcriptional regulator
Tharo_RS12100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tharo_RS12110	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Tharo_RS12120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tharo_RS12125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Tharo_RS12135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tharo_RS12140	COG2226	methyltransferase
Tharo_RS12155	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Tharo_RS12165	COG0303	'Molybdopterin
Tharo_RS12170	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Tharo_RS12180	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Tharo_RS12185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tharo_RS12185	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Tharo_RS12195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tharo_RS12200	COG0483	inositol monophosphate 1-phosphatase activity
Tharo_RS12205	COG3954	Phosphoribulokinase
Tharo_RS12215	COG0672	)-iron permease
Tharo_RS12235	COG5002	protein histidine kinase activity
Tharo_RS12240	COG0745	RESPONSE REGULATOR receiver
Tharo_RS12250	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
Tharo_RS12265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tharo_RS12270	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tharo_RS12290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tharo_RS12295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tharo_RS12300	COG0126	phosphoglycerate kinase activity
Tharo_RS12315	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Tharo_RS12335	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Tharo_RS12340	COG1074	ATP-dependent DNA helicase activity
Tharo_RS12345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tharo_RS12350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tharo_RS12355	COG2223	nitrite transmembrane transporter activity
Tharo_RS12400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tharo_RS12405	COG0006	proline dipeptidase activity
Tharo_RS12410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tharo_RS12420	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Tharo_RS12425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tharo_RS12430	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Tharo_RS12435	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tharo_RS12455	COG0281	malic enzyme
Tharo_RS12455	COG0280	phosphate acetyltransferase
Tharo_RS12495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tharo_RS12500	COG2274	protein secretion by the type I secretion system
Tharo_RS12515	COG1192	Involved in chromosome partitioning
Tharo_RS12525	COG0210	DNA helicase
Tharo_RS12535	COG0495	leucyl-tRNA aminoacylation
Tharo_RS12545	COG1466	dna polymerase III delta subunit
Tharo_RS12550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tharo_RS12560	COG4974	Belongs to the 'phage' integrase family
Tharo_RS12565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Tharo_RS12580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tharo_RS12585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tharo_RS12590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tharo_RS12610	COG3177	Filamentation induced by cAMP protein fic
Tharo_RS12620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tharo_RS12625	COG0628	permease
Tharo_RS12630	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tharo_RS12640	COG0617	tRNA 3'-terminal CCA addition
Tharo_RS12655	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tharo_RS12660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Tharo_RS12665	COG0517	IMP dehydrogenase activity
Tharo_RS12665	COG0516	GMP reductase activity
Tharo_RS12670	COG0308	aminopeptidase N
Tharo_RS12695	COG0028	Belongs to the TPP enzyme family
Tharo_RS12700	COG0440	acetolactate synthase activity
Tharo_RS12705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tharo_RS12710	COG1183	phosphatidylcholine synthase activity
Tharo_RS12715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tharo_RS12730	COG0228	four-way junction DNA binding
Tharo_RS12735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tharo_RS12740	COG0336	Belongs to the RNA methyltransferase TrmD family
Tharo_RS12745	COG0335	large ribosomal subunit rRNA binding
Tharo_RS12750	COG0795	lipopolysaccharide-transporting ATPase activity
Tharo_RS12755	COG0795	lipopolysaccharide-transporting ATPase activity
Tharo_RS12760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tharo_RS12775	COG0525	valine-tRNA ligase activity
Tharo_RS12780	COG0425	Belongs to the sulfur carrier protein TusA family
Tharo_RS12785	COG4783	chaperone-mediated protein folding
Tharo_RS12790	COG0315	cyclic pyranopterin monophosphate synthase activity
Tharo_RS12805	COG2205	protein histidine kinase activity
Tharo_RS12810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tharo_RS12820	COG0745	RESPONSE REGULATOR receiver
Tharo_RS12835	COG0840	transmembrane signaling receptor activity
Tharo_RS12855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tharo_RS12860	COG2414	aldehyde ferredoxin oxidoreductase
Tharo_RS12870	COG0163	prenyltransferase activity
Tharo_RS12875	COG1802	Transcriptional regulator
Tharo_RS12880	COG0183	Belongs to the thiolase family
Tharo_RS12900	COG1960	acyl-CoA dehydrogenase activity
Tharo_RS12910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tharo_RS12910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tharo_RS12930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tharo_RS12945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tharo_RS12950	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Tharo_RS12985	COG1902	pentaerythritol trinitrate reductase activity
Tharo_RS12985	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tharo_RS12990	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tharo_RS13000	COG3038	cytochrome b561
Tharo_RS13010	COG2353	YceI-like domain
Tharo_RS13015	COG0435	Glutathione S-transferase
Tharo_RS13050	COG0463	Glycosyl transferase, family 2
Tharo_RS13080	COG0142	geranyltranstransferase activity
Tharo_RS13085	COG1653	transport
Tharo_RS13090	COG0667	Aldo Keto reductase
Tharo_RS13095	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Tharo_RS13100	COG0513	Belongs to the DEAD box helicase family
Tharo_RS13110	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tharo_RS13120	COG0631	protein serine/threonine phosphatase activity
Tharo_RS13125	COG0247	lactate metabolic process
Tharo_RS13130	COG0277	FAD linked oxidase domain protein
Tharo_RS13140	COG0277	FAD linked oxidase domain protein
Tharo_RS13145	COG0583	DNA-binding transcription factor activity
Tharo_RS13150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tharo_RS13155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tharo_RS13160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tharo_RS13165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tharo_RS13170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tharo_RS13175	COG0604	alcohol dehydrogenase
Tharo_RS13180	COG0488	(ABC) transporter
Tharo_RS13195	COG0582	viral genome integration into host DNA
Tharo_RS13205	COG3093	addiction module antidote protein HigA
Tharo_RS13225	COG4628	conserved protein (DUF2132)
Tharo_RS13235	COG1401	restriction endodeoxyribonuclease activity
Tharo_RS13275	COG0009	L-threonylcarbamoyladenylate synthase
Tharo_RS13280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Tharo_RS13285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tharo_RS13290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tharo_RS13300	COG4566	intracellular signal transduction
Tharo_RS13315	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Tharo_RS13320	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tharo_RS13325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tharo_RS13345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tharo_RS13345	COG0047	phosphoribosylformylglycinamidine synthase activity
Tharo_RS13460	COG0582	viral genome integration into host DNA
Tharo_RS13475	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tharo_RS13480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tharo_RS13485	COG0740	serine-type endopeptidase activity
Tharo_RS13490	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tharo_RS13495	COG2766	serine protein kinase
Tharo_RS13500	COG2718	Belongs to the UPF0229 family
Tharo_RS13505	COG2719	SpoVR family
Tharo_RS13510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tharo_RS13510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tharo_RS13540	COG4372	Transposase
Tharo_RS13555	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tharo_RS13570	COG4680	protein conserved in bacteria
Tharo_RS13585	COG2084	Dehydrogenase
Tharo_RS13590	COG2084	Dehydrogenase
Tharo_RS13595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tharo_RS13605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Tharo_RS13615	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Tharo_RS13640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Tharo_RS13650	COG0629	single-stranded DNA binding
Tharo_RS13655	COG2814	Major facilitator Superfamily
Tharo_RS13665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tharo_RS13670	COG0203	ribosomal protein L17
Tharo_RS13675	COG0202	RNA polymerase activity
Tharo_RS13680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tharo_RS13685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tharo_RS13690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tharo_RS13695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tharo_RS13700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tharo_RS13705	COG0201	protein transport
Tharo_RS13710	COG0200	Binds to the 23S rRNA
Tharo_RS13715	COG1841	ribosomal large subunit assembly
Tharo_RS13720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tharo_RS13725	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tharo_RS13730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tharo_RS13735	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tharo_RS13740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tharo_RS13745	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tharo_RS13750	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tharo_RS13755	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tharo_RS13760	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tharo_RS13765	COG0255	Belongs to the universal ribosomal protein uL29 family
Tharo_RS13770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tharo_RS13775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tharo_RS13780	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tharo_RS13785	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tharo_RS13790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tharo_RS13795	COG0089	rRNA binding
Tharo_RS13800	COG0088	Forms part of the polypeptide exit tunnel
Tharo_RS13805	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tharo_RS13810	COG0051	transcription antitermination factor activity, RNA binding
Tharo_RS13815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tharo_RS13820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tharo_RS13825	COG0049	tRNA binding
Tharo_RS13830	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tharo_RS13835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tharo_RS13840	COG0085	RNA polymerase activity
Tharo_RS13845	COG0222	ribosome binding
Tharo_RS13850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tharo_RS13855	COG0081	regulation of translation
Tharo_RS13860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tharo_RS13870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tharo_RS13880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tharo_RS13900	COG0277	FAD linked oxidase domain protein
Tharo_RS13905	COG2197	response regulator
Tharo_RS13940	COG2894	cell division
Tharo_RS13965	COG4964	Belongs to the GSP D family
Tharo_RS13995	COG2201	protein-glutamate methylesterase activity
Tharo_RS14010	COG4566	intracellular signal transduction
Tharo_RS14035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tharo_RS14035	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tharo_RS14035	COG1703	isobutyryl-CoA mutase activity
Tharo_RS14055	COG0574	Belongs to the PEP-utilizing enzyme family
Tharo_RS14055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tharo_RS14060	COG0517	IMP dehydrogenase activity
Tharo_RS14070	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Tharo_RS14085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Tharo_RS14110	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Tharo_RS14130	COG1509	lysine 2,3-aminomutase activity
Tharo_RS14135	COG4770	biotin carboxylase activity
Tharo_RS14140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tharo_RS14145	COG1703	isobutyryl-CoA mutase activity
Tharo_RS14150	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tharo_RS14150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tharo_RS14155	COG1802	Transcriptional regulator
Tharo_RS14160	COG1253	flavin adenine dinucleotide binding
Tharo_RS14180	COG3706	GGDEF domain
Tharo_RS14200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tharo_RS14205	COG2274	protein secretion by the type I secretion system
Tharo_RS14220	COG1136	(ABC) transporter
Tharo_RS14220	COG0577	efflux transmembrane transporter activity
Tharo_RS14225	COG0735	belongs to the Fur family
Tharo_RS14245	COG0730	response to heat
Tharo_RS14260	COG2205	protein histidine kinase activity
Tharo_RS14265	COG0745	RESPONSE REGULATOR receiver
Tharo_RS14270	COG2197	response regulator
Tharo_RS14280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tharo_RS14280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tharo_RS14300	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Tharo_RS14310	COG0129	dihydroxy-acid dehydratase activity
Tharo_RS14315	COG3132	Protein of unknown function, DUF480
Tharo_RS14320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tharo_RS14385	COG0577	efflux transmembrane transporter activity
Tharo_RS14385	COG1136	(ABC) transporter
Tharo_RS14390	COG1538	Outer membrane efflux protein
Tharo_RS14395	COG4772	TonB-dependent receptor
Tharo_RS14440	COG4774	siderophore transport
Tharo_RS14445	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Tharo_RS14455	COG2217	Heavy metal translocating P-type atpase
Tharo_RS14485	COG0330	HflC and HflK could
Tharo_RS14540	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Tharo_RS14545	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tharo_RS14550	COG0824	Thioesterase
Tharo_RS14560	COG0848	biopolymer transport protein
Tharo_RS14570	COG0823	Involved in the tonB-independent uptake of proteins
Tharo_RS14585	COG0602	queuosine metabolic process
Tharo_RS14590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Tharo_RS14660	COG0582	viral genome integration into host DNA
Tharo_RS14665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tharo_RS14670	COG0412	Dienelactone hydrolase
Tharo_RS14685	COG1660	Displays ATPase and GTPase activities
Tharo_RS14695	COG2204	response regulator
Tharo_RS14715	COG1012	belongs to the aldehyde dehydrogenase family
Tharo_RS14755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tharo_RS14765	COG0511	ligase activity, forming carbon-carbon bonds
Tharo_RS14770	COG0439	Biotin carboxylase
Tharo_RS14800	COG0183	Belongs to the thiolase family
Tharo_RS14810	COG0604	alcohol dehydrogenase
Tharo_RS14830	COG1404	Belongs to the peptidase S8 family
Tharo_RS14835	COG1132	(ABC) transporter
Tharo_RS14840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tharo_RS14855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tharo_RS14860	COG1309	transcriptional regulator
Tharo_RS14865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tharo_RS14870	COG4948	Mandelate Racemase Muconate Lactonizing
Tharo_RS14885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tharo_RS14900	COG1024	Enoyl-CoA hydratase
Tharo_RS14905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tharo_RS14910	COG0183	Belongs to the thiolase family
Tharo_RS14915	COG1960	acyl-CoA dehydrogenase activity
Tharo_RS14925	COG3243	poly(R)-hydroxyalkanoic acid synthase
Tharo_RS14945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tharo_RS14955	COG0018	arginyl-trna synthetase
Tharo_RS14960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tharo_RS14965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tharo_RS14975	COG0826	peptidase U32
Tharo_RS14980	COG0826	peptidase U32
Tharo_RS14985	COG3154	lipid carrier protein
Tharo_RS14990	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Tharo_RS14995	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Tharo_RS15000	COG1546	Belongs to the CinA family
Tharo_RS15005	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tharo_RS15010	COG2137	regulation of response to DNA damage stimulus
Tharo_RS15015	COG1137	ATPase activity
Tharo_RS15020	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Tharo_RS15025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Tharo_RS15035	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Tharo_RS15040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Tharo_RS15045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Tharo_RS15055	COG0702	epimerase
Tharo_RS15065	COG0617	tRNA 3'-terminal CCA addition
Tharo_RS15070	COG0625	glutathione transferase activity
Tharo_RS15075	COG2267	carboxylic ester hydrolase activity
Tharo_RS15080	COG0840	transmembrane signaling receptor activity
Tharo_RS15090	COG1028	Short-chain dehydrogenase reductase Sdr
Tharo_RS15095	COG0037	tRNA processing
Tharo_RS15105	COG1238	metal cluster binding
Tharo_RS15115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tharo_RS15125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tharo_RS15130	COG0708	Exodeoxyribonuclease III
Tharo_RS15145	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Tharo_RS15155	COG2814	Major facilitator Superfamily
Tharo_RS15160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tharo_RS15170	COG2409	Drug exporters of the RND superfamily
Tharo_RS15190	COG3474	cytochrome
Tharo_RS15290	COG1518	maintenance of DNA repeat elements
Tharo_RS15295	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tharo_RS15305	COG0438	transferase activity, transferring glycosyl groups
Tharo_RS15340	COG1024	Enoyl-CoA hydratase
Tharo_RS15355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tharo_RS15375	COG0583	DNA-binding transcription factor activity
Tharo_RS15400	COG0180	Tryptophanyl-tRNA synthetase
Tharo_RS15415	COG0668	transmembrane transport
Tharo_RS15425	COG0784	Response regulator, receiver
Tharo_RS15425	COG2205	protein histidine kinase activity
Tharo_RS15435	COG3876	Protein conserved in bacteria
Tharo_RS15440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tharo_RS15445	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Tharo_RS15455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tharo_RS15545	COG2814	Major facilitator Superfamily
Tharo_RS15570	COG2161	toxin-antitoxin pair type II binding
Tharo_RS15575	COG4115	mRNA cleavage
Tharo_RS15580	COG1881	PFAM PEBP family protein
Tharo_RS15585	COG1024	Enoyl-CoA hydratase
Tharo_RS15605	COG1028	Short-chain dehydrogenase reductase Sdr
Tharo_RS15610	COG1028	Short-chain dehydrogenase reductase Sdr
Tharo_RS15615	COG0604	alcohol dehydrogenase
Tharo_RS15615	COG3321	synthase
Tharo_RS15615	COG1028	Short-chain dehydrogenase reductase Sdr
Tharo_RS15625	COG3781	membrane
Tharo_RS15670	COG2814	Major facilitator Superfamily
Tharo_RS15675	COG0606	chelatase, subunit chli
Tharo_RS15690	COG0347	Belongs to the P(II) protein family
Tharo_RS15695	COG0004	ammonium transporteR
Tharo_RS15750	COG2204	response regulator
Tharo_RS15755	COG4191	Histidine kinase
Tharo_RS15765	COG0488	(ABC) transporter
Tharo_RS15780	COG0697	spore germination
Tharo_RS15795	COG0189	ligase activity
Tharo_RS15810	COG2226	methyltransferase
Tharo_RS15815	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
Tharo_RS15835	COG3409	Peptidoglycan-binding domain 1 protein
Tharo_RS15835	COG3267	Type II secretory pathway component ExeA
Tharo_RS15845	COG1943	Transposase
Tharo_RS15855	COG0827	DNA restriction-modification system
Tharo_RS15855	COG0732	type I restriction modification DNA specificity domain
Tharo_RS15860	COG0318	PFAM AMP-dependent synthetase and ligase
Tharo_RS15870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tharo_RS15875	COG3189	MarR family transcriptional regulator
Tharo_RS15880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Tharo_RS15925	COG3012	SEC-C Motif Domain Protein
Tharo_RS15935	COG1611	Belongs to the LOG family
Tharo_RS15955	COG1028	Short-chain dehydrogenase reductase Sdr
Tharo_RS15965	COG2204	response regulator
Tharo_RS15980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tharo_RS15995	COG1739	Uncharacterized protein family UPF0029
Tharo_RS16010	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Tharo_RS16015	COG0653	protein targeting
Tharo_RS16035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tharo_RS16055	COG0523	cobalamin synthesis protein
Tharo_RS16070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tharo_RS16075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tharo_RS16085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tharo_RS16085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tharo_RS16105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Tharo_RS16120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tharo_RS16125	COG0799	negative regulation of ribosome biogenesis
Tharo_RS16130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Tharo_RS16135	COG0424	maF-like protein
Tharo_RS16140	COG1530	ribonuclease E activity
Tharo_RS16160	COG0632	four-way junction helicase activity
Tharo_RS16165	COG2255	four-way junction helicase activity
Tharo_RS16170	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Tharo_RS16180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tharo_RS16185	COG1560	Kdo2-lipid A biosynthetic process
Tharo_RS16195	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tharo_RS16225	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Tharo_RS16255	COG1797	cobyrinic acid a,c-diamide synthase activity
Tharo_RS16260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tharo_RS16260	COG1648	precorrin-2 dehydrogenase activity
Tharo_RS16270	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Tharo_RS16275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tharo_RS16280	COG4206	TonB-dependent receptor
Tharo_RS16290	COG4636	protein conserved in cyanobacteria
Tharo_RS16295	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tharo_RS16300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Tharo_RS16330	COG3657	addiction module killer protein
Tharo_RS16375	COG0406	alpha-ribazole phosphatase activity
Tharo_RS16385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tharo_RS16390	COG0859	PFAM glycosyl transferase family 9
Tharo_RS16395	COG0859	PFAM glycosyl transferase family 9
Tharo_RS16400	COG0438	transferase activity, transferring glycosyl groups
Tharo_RS16415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tharo_RS16435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tharo_RS16445	COG0642	Histidine kinase
Tharo_RS16450	COG1368	sulfuric ester hydrolase activity
Tharo_RS16460	COG3642	lipopolysaccharide core region biosynthetic process
Tharo_RS16465	COG1132	(ABC) transporter
Tharo_RS16485	COG2192	nodulation
Tharo_RS16490	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Tharo_RS16490	COG2755	lipolytic protein G-D-S-L family
Tharo_RS16500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tharo_RS16510	COG1396	sequence-specific DNA binding
Tharo_RS16520	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Tharo_RS16520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Tharo_RS16525	COG1324	tolerance protein
Tharo_RS16530	COG4232	protein-disulfide reductase activity
Tharo_RS16545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tharo_RS16550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tharo_RS16555	COG0375	protein maturation
Tharo_RS16565	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Tharo_RS16570	COG0298	carbon dioxide binding
Tharo_RS16575	COG0409	Hydrogenase expression formation protein
Tharo_RS16580	COG0309	Hydrogenase expression formation protein (HypE)
Tharo_RS16590	COG1012	belongs to the aldehyde dehydrogenase family
Tharo_RS16605	COG0513	Belongs to the DEAD box helicase family
Tharo_RS16620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tharo_RS16625	COG1194	a g-specific adenine glycosylase
Tharo_RS16635	COG1454	alcohol dehydrogenase
Tharo_RS16640	COG1012	belongs to the aldehyde dehydrogenase family
Tharo_RS16645	COG3284	Transcriptional regulator
Tharo_RS16655	COG2860	membrane
Tharo_RS16665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tharo_RS16670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tharo_RS16685	COG2814	Major facilitator Superfamily
Tharo_RS16690	COG0583	DNA-binding transcription factor activity
Tharo_RS16695	COG0004	ammonium transporteR
Tharo_RS16705	COG0826	peptidase U32
Tharo_RS16710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Tharo_RS16745	COG1561	YicC-like family, N-terminal region
Tharo_RS16755	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Tharo_RS16760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tharo_RS16770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tharo_RS16775	COG4772	TonB-dependent receptor
Tharo_RS16830	COG0616	signal peptide processing
Tharo_RS16835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Tharo_RS16840	COG2022	thiamine diphosphate biosynthetic process
Tharo_RS16850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tharo_RS16855	COG2813	Specifically methylates the guanine in position
Tharo_RS16855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tharo_RS16865	COG2814	Major facilitator Superfamily
Tharo_RS16875	COG1136	(ABC) transporter
Tharo_RS16875	COG0577	efflux transmembrane transporter activity
Tharo_RS16910	COG0642	Histidine kinase
Tharo_RS16980	COG4177	L-phenylalanine transmembrane transporter activity
Tharo_RS16985	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tharo_RS16995	COG1021	2,3-dihydroxybenzoate-AMP ligase
Tharo_RS17010	COG1902	pentaerythritol trinitrate reductase activity
Tharo_RS17010	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tharo_RS17035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tharo_RS17055	COG0288	reversible hydration of carbon dioxide
Tharo_RS17070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tharo_RS17075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tharo_RS17080	COG0675	Transposase, IS605 OrfB family
Tharo_RS17090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tharo_RS17100	COG0569	domain protein
Tharo_RS17105	COG2204	response regulator
Tharo_RS17110	COG5000	phosphorelay sensor kinase activity
Tharo_RS17125	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tharo_RS17130	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Tharo_RS17140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tharo_RS17155	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tharo_RS17160	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tharo_RS17165	COG0706	membrane insertase activity
Tharo_RS17170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tharo_RS17175	COG0594	ribonuclease P activity
Tharo_RS17180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Tharo_RS17205	COG4962	Type ii secretion system protein e
Tharo_RS17210	COG3838	Conjugal transfer protein Trbc
Tharo_RS17215	COG5268	conjugation
Tharo_RS17220	COG3451	type IV secretory pathway VirB4
Tharo_RS17320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tharo_RS17390	COG0697	spore germination
Tharo_RS17415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone