locus-tag	class	description
Tchl_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tchl_RS00025	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tchl_RS00065	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tchl_RS00075	COG3609	addiction module antidote protein, CC2985 family
Tchl_RS00125	COG1451	nucleotide metabolic process
Tchl_RS00140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tchl_RS00145	COG2814	Major facilitator Superfamily
Tchl_RS00155	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Tchl_RS00175	COG3264	Mechanosensitive ion channel
Tchl_RS00175	COG1196	nuclear chromosome segregation
Tchl_RS00185	COG1116	anion transmembrane transporter activity
Tchl_RS00190	COG0390	transport system, permease component
Tchl_RS00195	COG0679	Auxin Efflux Carrier
Tchl_RS00200	COG0114	fumarate hydratase activity
Tchl_RS00215	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Tchl_RS00240	COG2974	May be involved in recombination
Tchl_RS00250	COG1187	pseudouridine synthase activity
Tchl_RS00265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tchl_RS00285	COG2212	antiporter activity
Tchl_RS00290	COG1863	multisubunit Na H antiporter MnhE subunit
Tchl_RS00295	COG0651	ATP synthesis coupled electron transport
Tchl_RS00300	COG1006	Multisubunit Na H antiporter MnhC subunit
Tchl_RS00305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tchl_RS00305	COG2111	Na H antiporter
Tchl_RS00330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tchl_RS00340	COG3909	cytochrome
Tchl_RS00345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tchl_RS00355	COG0783	Belongs to the Dps family
Tchl_RS00375	COG2922	Belongs to the Smg family
Tchl_RS00380	COG0758	DNA mediated transformation
Tchl_RS00385	COG1652	LysM domain
Tchl_RS00390	COG0242	peptide deformylase activity
Tchl_RS00395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tchl_RS00400	COG0501	Belongs to the peptidase M48B family
Tchl_RS00405	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Tchl_RS00425	COG1132	(ABC) transporter
Tchl_RS00430	COG0420	3'-5' exonuclease activity
Tchl_RS00465	COG1960	acyl-CoA dehydrogenase activity
Tchl_RS00475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tchl_RS00505	COG0243	molybdopterin cofactor binding
Tchl_RS00510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tchl_RS00515	COG1910	domain protein
Tchl_RS00520	COG1960	acyl-CoA dehydrogenase activity
Tchl_RS00525	COG1960	acyl-CoA dehydrogenase activity
Tchl_RS00535	COG0445	tRNA wobble uridine modification
Tchl_RS00540	COG0357	Ribosomal RNA small subunit methyltransferase G
Tchl_RS00545	COG1192	Involved in chromosome partitioning
Tchl_RS00550	COG1475	DNA binding
Tchl_RS00565	COG0356	it plays a direct role in the translocation of protons across the membrane
Tchl_RS00575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tchl_RS00580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tchl_RS00585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tchl_RS00590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tchl_RS00595	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tchl_RS00600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tchl_RS00615	COG2226	methyltransferase
Tchl_RS00625	COG0745	RESPONSE REGULATOR receiver
Tchl_RS00640	COG0121	glutamine amidotransferase
Tchl_RS00645	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tchl_RS00655	COG4372	Transposase
Tchl_RS00675	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tchl_RS00680	COG0154	amidase activity
Tchl_RS00685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tchl_RS00690	COG1077	Cell shape determining protein MreB Mrl
Tchl_RS00700	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Tchl_RS00705	COG0768	penicillin binding
Tchl_RS00710	COG0772	Belongs to the SEDS family
Tchl_RS00720	COG1686	Belongs to the peptidase S11 family
Tchl_RS00730	COG2921	Belongs to the UPF0250 family
Tchl_RS00735	COG0321	lipoyl(octanoyl) transferase activity
Tchl_RS00740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Tchl_RS00750	COG0210	DNA helicase
Tchl_RS00795	COG1074	ATP-dependent DNA helicase activity
Tchl_RS00805	COG5002	protein histidine kinase activity
Tchl_RS00830	COG2132	Multicopper oxidase
Tchl_RS00850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_RS00855	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tchl_RS00960	COG0583	DNA-binding transcription factor activity
Tchl_RS01055	COG0277	FAD linked oxidase domain protein
Tchl_RS01060	COG1944	ATP diphosphatase activity
Tchl_RS01065	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tchl_RS01070	COG2336	PFAM SpoVT AbrB
Tchl_RS01075	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tchl_RS01080	COG3657	addiction module killer protein
Tchl_RS01105	COG1959	2 iron, 2 sulfur cluster binding
Tchl_RS01115	COG0583	DNA-binding transcription factor activity
Tchl_RS01130	COG0625	glutathione transferase activity
Tchl_RS01135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tchl_RS01145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_RS01185	COG0194	GDP metabolic process
Tchl_RS01190	COG1758	RNA polymerase activity
Tchl_RS01195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tchl_RS01205	COG5002	protein histidine kinase activity
Tchl_RS01205	COG2176	DNA-directed DNA polymerase activity
Tchl_RS01215	COG3850	Histidine kinase
Tchl_RS01220	COG2197	response regulator
Tchl_RS01225	COG4133	protoheme IX ABC transporter activity
Tchl_RS01230	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tchl_RS01245	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Tchl_RS01255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tchl_RS01260	COG3088	subunit of a heme lyase
Tchl_RS01265	COG4235	cytochrome complex assembly
Tchl_RS01270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tchl_RS01370	COG0776	regulation of translation
Tchl_RS01390	COG2326	polyphosphate kinase activity
Tchl_RS01400	COG0583	DNA-binding transcription factor activity
Tchl_RS01420	COG4372	Transposase
Tchl_RS01435	COG4974	Belongs to the 'phage' integrase family
Tchl_RS01440	COG1285	pathogenesis
Tchl_RS01450	COG0583	DNA-binding transcription factor activity
Tchl_RS01475	COG1484	DNA-dependent DNA replication
Tchl_RS01480	COG4584	PFAM Integrase catalytic
Tchl_RS01585	COG2003	Belongs to the UPF0758 family
Tchl_RS01670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tchl_RS01700	COG0583	DNA-binding transcription factor activity
Tchl_RS01705	COG1396	sequence-specific DNA binding
Tchl_RS01715	COG0582	viral genome integration into host DNA
Tchl_RS01725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tchl_RS01730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tchl_RS01735	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tchl_RS01735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tchl_RS01740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Tchl_RS01775	COG1558	bacterial-type flagellum-dependent cell motility
Tchl_RS01785	COG1749	Flagellar hook protein flgE
Tchl_RS01790	COG4787	bacterial-type flagellum-dependent cell motility
Tchl_RS01795	COG4786	Flagellar basal body rod
Tchl_RS01800	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Tchl_RS01805	COG1706	bacterial-type flagellum-dependent cell motility
Tchl_RS01815	COG1256	bacterial-type flagellum assembly
Tchl_RS01830	COG1987	bacterial-type flagellum assembly
Tchl_RS01835	COG1338	Plays a role in the flagellum-specific transport system
Tchl_RS01855	COG1580	Controls the rotational direction of flagella during chemotaxis
Tchl_RS01880	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tchl_RS01895	COG1334	flagellar protein FlaG
Tchl_RS01900	COG0840	transmembrane signaling receptor activity
Tchl_RS01910	COG1487	ribonuclease activity
Tchl_RS01930	COG4372	Transposase
Tchl_RS02080	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Tchl_RS02100	COG2257	FlhB HrpN YscU SpaS Family
Tchl_RS02120	COG1360	Flagellar Motor Protein
Tchl_RS02125	COG0643	Histidine kinase
Tchl_RS02125	COG2198	Histidine kinase
Tchl_RS02130	COG0835	chemotaxis
Tchl_RS02135	COG0840	transmembrane signaling receptor activity
Tchl_RS02140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tchl_RS02145	COG2201	protein-glutamate methylesterase activity
Tchl_RS02150	COG0745	RESPONSE REGULATOR receiver
Tchl_RS02165	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tchl_RS02185	COG1191	sigma factor activity
Tchl_RS02190	COG0488	(ABC) transporter
Tchl_RS02195	COG5001	Diguanylate cyclase
Tchl_RS02195	COG4251	negative regulation of phosphorylation
Tchl_RS02195	COG2203	Gaf domain
Tchl_RS02195	COG3706	GGDEF domain
Tchl_RS02200	COG0625	glutathione transferase activity
Tchl_RS02225	COG0513	Belongs to the DEAD box helicase family
Tchl_RS02235	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
Tchl_RS02250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tchl_RS02255	COG0393	Putative heavy-metal-binding
Tchl_RS02260	COG0697	spore germination
Tchl_RS02265	COG0217	transcriptional regulatory protein
Tchl_RS02270	COG0583	DNA-binding transcription factor activity
Tchl_RS02290	COG0433	COG0433 Predicted ATPase
Tchl_RS02295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Tchl_RS02300	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Tchl_RS02305	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tchl_RS02310	COG0688	phosphatidylethanolamine metabolic process
Tchl_RS02315	COG0840	transmembrane signaling receptor activity
Tchl_RS02320	COG0513	Belongs to the DEAD box helicase family
Tchl_RS02330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tchl_RS02340	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Tchl_RS02345	COG1492	cobalamin metabolic process
Tchl_RS02350	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tchl_RS02350	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tchl_RS02355	COG4654	Cytochrome c, class I
Tchl_RS02360	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Tchl_RS02375	COG1981	membrane
Tchl_RS02385	COG3852	Histidine kinase
Tchl_RS02390	COG1763	Mo-molybdopterin cofactor biosynthetic process
Tchl_RS02400	COG0746	molybdenum cofactor guanylyltransferase activity
Tchl_RS02435	COG0243	molybdopterin cofactor binding
Tchl_RS02435	COG3383	formate dehydrogenase (NAD+) activity
Tchl_RS02440	COG0437	4 iron, 4 sulfur cluster binding
Tchl_RS02490	COG0540	Belongs to the ATCase OTCase family
Tchl_RS02495	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tchl_RS02500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tchl_RS02505	COG1678	Uncharacterized ACR, COG1678
Tchl_RS02510	COG0415	Belongs to the DNA photolyase family
Tchl_RS02515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Tchl_RS02530	COG0352	thiamine-phosphate diphosphorylase activity
Tchl_RS02535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tchl_RS02540	COG3622	Belongs to the hyi family
Tchl_RS02545	COG2239	Acts as a magnesium transporter
Tchl_RS02550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tchl_RS02555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tchl_RS02565	COG0557	exoribonuclease II activity
Tchl_RS02570	COG2226	methyltransferase
Tchl_RS02575	COG3150	esterase
Tchl_RS02580	COG1968	undecaprenyl-diphosphatase activity
Tchl_RS02585	COG1618	nucleotide phosphatase activity, acting on free nucleotides
Tchl_RS02585	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Tchl_RS02590	COG1643	Atp-dependent helicase
Tchl_RS02600	COG0360	Binds together with S18 to 16S ribosomal RNA
Tchl_RS02605	COG2965	DNA replication, synthesis of RNA primer
Tchl_RS02610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tchl_RS02615	COG0359	binds to the 23S rRNA
Tchl_RS02620	COG0305	Participates in initiation and elongation during chromosome replication
Tchl_RS02650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tchl_RS02655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tchl_RS02660	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Tchl_RS02670	COG0494	nUDIX hydrolase
Tchl_RS02675	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Tchl_RS02680	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Tchl_RS02685	COG0237	dephospho-CoA kinase activity
Tchl_RS02695	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Tchl_RS02700	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tchl_RS02715	COG3852	Histidine kinase
Tchl_RS02725	COG0174	glutamine synthetase
Tchl_RS02730	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tchl_RS02740	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tchl_RS02745	COG3568	Endonuclease Exonuclease Phosphatase
Tchl_RS02755	COG1832	CoA-binding protein
Tchl_RS02760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tchl_RS02765	COG3245	cytochrome
Tchl_RS02815	COG4263	nitrous-oxide reductase activity
Tchl_RS02830	COG3706	GGDEF domain
Tchl_RS02835	COG0012	GTP binding
Tchl_RS02840	COG0193	aminoacyl-tRNA hydrolase activity
Tchl_RS02845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tchl_RS02850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tchl_RS02860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tchl_RS02865	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Tchl_RS02875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tchl_RS02880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tchl_RS02885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tchl_RS02890	COG0742	ribosomal rna small subunit methyltransferase
Tchl_RS02895	COG0612	Peptidase, M16
Tchl_RS02900	COG0612	Peptidase, M16
Tchl_RS02910	COG2884	Cell division ATP-binding protein ftsE
Tchl_RS02920	COG0450	alkyl hydroperoxide reductase
Tchl_RS02925	COG3634	alkyl hydroperoxide reductase activity
Tchl_RS02930	COG1132	(ABC) transporter
Tchl_RS02950	COG3550	peptidyl-serine autophosphorylation
Tchl_RS02955	COG1396	sequence-specific DNA binding
Tchl_RS02985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tchl_RS02990	COG1702	phosphate starvation-inducible protein PhoH
Tchl_RS02995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tchl_RS03000	COG4535	Mg2 and Co2 transporter CorC
Tchl_RS03005	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Tchl_RS03010	COG0752	glycyl-tRNA synthetase alpha subunit
Tchl_RS03015	COG0751	glycine-tRNA ligase activity
Tchl_RS03020	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Tchl_RS03025	COG0204	Acyl-transferase
Tchl_RS03040	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Tchl_RS03055	COG4537	Required for transformation and DNA binding
Tchl_RS03075	COG1459	type II secretion system
Tchl_RS03080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Tchl_RS03090	COG1127	ABC transporter
Tchl_RS03095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tchl_RS03100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Tchl_RS03105	COG2853	Lipoprotein
Tchl_RS03120	COG1131	(ABC) transporter
Tchl_RS03125	COG0842	Transport permease protein
Tchl_RS03135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tchl_RS03140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tchl_RS03145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tchl_RS03150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tchl_RS03155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tchl_RS03160	COG0131	Imidazoleglycerol-phosphate dehydratase
Tchl_RS03165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tchl_RS03170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Tchl_RS03175	COG0107	imidazoleglycerol-phosphate synthase activity
Tchl_RS03180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tchl_RS03185	COG0140	phosphoribosyl-ATP diphosphatase activity
Tchl_RS03190	COG0537	adenosine 5'-monophosphoramidase activity
Tchl_RS03195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tchl_RS03200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tchl_RS03205	COG0805	protein transport
Tchl_RS03215	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Tchl_RS03230	COG0045	succinate-CoA ligase (ADP-forming) activity
Tchl_RS03235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tchl_RS03240	COG1716	ATPase activity
Tchl_RS03250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Tchl_RS03255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tchl_RS03260	COG0546	phosphoglycolate phosphatase activity
Tchl_RS03275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tchl_RS03280	COG0134	indole-3-glycerol-phosphate synthase activity
Tchl_RS03290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tchl_RS03315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tchl_RS03320	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Tchl_RS03350	COG0109	protoheme IX farnesyltransferase activity
Tchl_RS03355	COG1999	signal sequence binding
Tchl_RS03380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tchl_RS03385	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tchl_RS03415	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_RS03420	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Tchl_RS03425	COG1040	competence protein
Tchl_RS03440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tchl_RS03450	COG2119	membrane
Tchl_RS03455	COG2895	sulfate adenylyltransferase (ATP) activity
Tchl_RS03460	COG0175	sulfate reduction
Tchl_RS03465	COG0175	sulfate reduction
Tchl_RS03480	COG0730	response to heat
Tchl_RS03485	COG0583	DNA-binding transcription factor activity
Tchl_RS03490	COG0252	asparaginase activity
Tchl_RS03500	COG5265	(ABC) transporter
Tchl_RS03510	COG1960	acyl-CoA dehydrogenase activity
Tchl_RS03515	COG1607	acyl-coa hydrolase
Tchl_RS03520	COG1024	Enoyl-CoA hydratase
Tchl_RS03520	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tchl_RS03525	COG0183	Belongs to the thiolase family
Tchl_RS03535	COG1805	sodium ion transport
Tchl_RS03570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tchl_RS03575	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Tchl_RS03595	COG0284	orotidine-5'-phosphate decarboxylase activity
Tchl_RS03600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Tchl_RS03630	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_RS03675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tchl_RS03680	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_RS03715	COG1965	Belongs to the frataxin family
Tchl_RS03750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tchl_RS03755	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tchl_RS03760	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tchl_RS03765	COG0070	glutamate synthase
Tchl_RS03765	COG0067	glutamate synthase
Tchl_RS03765	COG0069	glutamate synthase activity
Tchl_RS03780	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tchl_RS03790	COG0405	Gamma-glutamyltransferase
Tchl_RS03795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tchl_RS03810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Tchl_RS03820	COG2030	dehydratase
Tchl_RS03825	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tchl_RS03835	COG5002	protein histidine kinase activity
Tchl_RS03845	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
Tchl_RS03860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_RS03865	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tchl_RS03875	COG3058	Necessary for formate dehydrogenase activity
Tchl_RS03890	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Tchl_RS03910	COG0243	molybdopterin cofactor binding
Tchl_RS03915	COG3023	N-Acetylmuramoyl-L-alanine amidase
Tchl_RS03920	COG0741	lytic transglycosylase activity
Tchl_RS03925	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Tchl_RS03950	COG1414	Transcriptional regulator
Tchl_RS03955	COG2111	Na H antiporter
Tchl_RS03955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tchl_RS03960	COG1006	Multisubunit Na H antiporter MnhC subunit
Tchl_RS03965	COG0651	ATP synthesis coupled electron transport
Tchl_RS03975	COG2212	antiporter activity
Tchl_RS03980	COG1320	monovalent cation:proton antiporter activity
Tchl_RS03995	COG1187	pseudouridine synthase activity
Tchl_RS04000	COG1320	monovalent cation:proton antiporter activity
Tchl_RS04005	COG2212	antiporter activity
Tchl_RS04010	COG1863	multisubunit Na H antiporter MnhE subunit
Tchl_RS04015	COG0651	ATP synthesis coupled electron transport
Tchl_RS04020	COG1006	Multisubunit Na H antiporter MnhC subunit
Tchl_RS04025	COG2111	Na H antiporter
Tchl_RS04025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tchl_RS04040	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tchl_RS04055	COG4372	Transposase
Tchl_RS04075	COG0732	type I restriction modification DNA specificity domain
Tchl_RS04080	COG4804	nuclease activity
Tchl_RS04085	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tchl_RS04090	COG1136	(ABC) transporter
Tchl_RS04090	COG0577	efflux transmembrane transporter activity
Tchl_RS04100	COG1136	(ABC) transporter
Tchl_RS04100	COG0577	efflux transmembrane transporter activity
Tchl_RS04115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tchl_RS04120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tchl_RS04125	COG3047	cAMP biosynthetic process
Tchl_RS04125	COG2885	chlorophyll binding
Tchl_RS04130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tchl_RS04135	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Tchl_RS04140	COG0351	phosphomethylpyrimidine kinase
Tchl_RS04145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tchl_RS04165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Tchl_RS04170	COG4115	mRNA cleavage
Tchl_RS04190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tchl_RS04205	COG2264	protein methyltransferase activity
Tchl_RS04210	COG0439	Biotin carboxylase
Tchl_RS04215	COG0511	ligase activity, forming carbon-carbon bonds
Tchl_RS04220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tchl_RS04230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tchl_RS04240	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tchl_RS04245	COG0792	nuclease activity
Tchl_RS04255	COG0418	dihydroorotase activity
Tchl_RS04260	COG0840	transmembrane signaling receptor activity
Tchl_RS04270	COG2001	Belongs to the MraZ family
Tchl_RS04275	COG0275	rRNA processing
Tchl_RS04290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tchl_RS04295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tchl_RS04300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tchl_RS04305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Tchl_RS04310	COG0772	Belongs to the SEDS family
Tchl_RS04315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tchl_RS04320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tchl_RS04325	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tchl_RS04330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Tchl_RS04340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tchl_RS04345	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Tchl_RS04370	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Tchl_RS04375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tchl_RS04380	COG0438	transferase activity, transferring glycosyl groups
Tchl_RS04395	COG4456	Virulence-associated protein
Tchl_RS04410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tchl_RS04435	COG0297	glycogen (starch) synthase activity
Tchl_RS04450	COG2089	acid synthase
Tchl_RS04460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tchl_RS04475	COG1083	cytidylyl-transferase
Tchl_RS04490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tchl_RS04495	COG1086	Polysaccharide biosynthesis protein
Tchl_RS04560	COG0653	protein targeting
Tchl_RS04565	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tchl_RS04575	COG3447	MASE1 domain protein
Tchl_RS04575	COG5002	protein histidine kinase activity
Tchl_RS04575	COG5001	Diguanylate cyclase
Tchl_RS04595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tchl_RS04600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tchl_RS04605	COG1862	Preprotein translocase
Tchl_RS04610	COG0343	queuine tRNA-ribosyltransferase activity
Tchl_RS04615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tchl_RS04685	COG0583	DNA-binding transcription factor activity
Tchl_RS04695	COG0670	Belongs to the BI1 family
Tchl_RS04700	COG0825	malonyl-CoA metabolic process
Tchl_RS04705	COG0037	tRNA processing
Tchl_RS04710	COG4566	intracellular signal transduction
Tchl_RS04735	COG0105	UTP biosynthetic process
Tchl_RS04740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tchl_RS04755	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tchl_RS04760	COG0124	histidyl-tRNA synthetase
Tchl_RS04770	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tchl_RS04775	COG1160	GTP binding
Tchl_RS04780	COG1923	regulation of RNA biosynthetic process
Tchl_RS04785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tchl_RS04790	COG0330	HflC and HflK could
Tchl_RS04795	COG0330	HflC and HflK could
Tchl_RS04805	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Tchl_RS04810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tchl_RS04825	COG0557	exoribonuclease II activity
Tchl_RS04830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tchl_RS04835	COG0778	Nitroreductase
Tchl_RS04840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tchl_RS04850	COG2223	nitrite transmembrane transporter activity
Tchl_RS04855	COG2815	serine threonine protein kinase
Tchl_RS04855	COG0515	serine threonine protein kinase
Tchl_RS04860	COG0243	molybdopterin cofactor binding
Tchl_RS04885	COG0745	RESPONSE REGULATOR receiver
Tchl_RS04905	COG3706	GGDEF domain
Tchl_RS04905	COG2203	Gaf domain
Tchl_RS04905	COG5001	Diguanylate cyclase
Tchl_RS04905	COG4251	negative regulation of phosphorylation
Tchl_RS04915	COG3273	potassium ion transport
Tchl_RS04915	COG0471	metal ion transport
Tchl_RS04930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tchl_RS04935	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tchl_RS04940	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tchl_RS04945	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tchl_RS04950	COG0723	plastoquinol--plastocyanin reductase activity
Tchl_RS04955	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Tchl_RS04960	COG2857	Cytochrome c1
Tchl_RS04965	COG0625	glutathione transferase activity
Tchl_RS04970	COG2969	positive regulation of protein catabolic process
Tchl_RS04980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tchl_RS04985	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Tchl_RS05005	COG1335	isochorismatase
Tchl_RS05010	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tchl_RS05020	COG0459	protein refolding
Tchl_RS05025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tchl_RS05030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tchl_RS05035	COG0022	dehydrogenase e1 component
Tchl_RS05035	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tchl_RS05045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tchl_RS05050	COG1902	pentaerythritol trinitrate reductase activity
Tchl_RS05060	COG1067	ATP-dependent peptidase activity
Tchl_RS05065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tchl_RS05070	COG0459	protein refolding
Tchl_RS05080	COG0642	Histidine kinase
Tchl_RS05090	COG2814	Major facilitator Superfamily
Tchl_RS05095	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tchl_RS05100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tchl_RS05105	COG2890	protein-(glutamine-N5) methyltransferase activity
Tchl_RS05110	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tchl_RS05125	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Tchl_RS05140	COG4536	flavin adenine dinucleotide binding
Tchl_RS05150	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tchl_RS05180	COG2070	2-Nitropropane dioxygenase
Tchl_RS05190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_RS05195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tchl_RS05205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tchl_RS05210	COG1238	metal cluster binding
Tchl_RS05215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tchl_RS05220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Tchl_RS05230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tchl_RS05230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tchl_RS05240	COG0720	synthase
Tchl_RS05255	COG0527	aspartate kinase activity
Tchl_RS05265	COG3384	dioxygenase
Tchl_RS05280	COG2159	amidohydrolase
Tchl_RS05310	COG0667	Aldo Keto reductase
Tchl_RS05315	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tchl_RS05320	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tchl_RS05345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Tchl_RS05355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_RS05365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tchl_RS05395	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_RS05400	COG1024	Enoyl-CoA hydratase
Tchl_RS05405	COG0183	Belongs to the thiolase family
Tchl_RS05420	COG0367	asparagine synthase
Tchl_RS05425	COG0189	ligase activity
Tchl_RS05425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tchl_RS05430	COG1363	Peptidase, m42
Tchl_RS05450	COG0277	FAD linked oxidase domain protein
Tchl_RS05460	COG2910	NAD(P)H-binding
Tchl_RS05475	COG3712	iron ion homeostasis
Tchl_RS05480	COG1595	DNA-templated transcription, initiation
Tchl_RS05495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tchl_RS05540	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tchl_RS05545	COG4177	L-phenylalanine transmembrane transporter activity
Tchl_RS05590	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_RS05615	COG0642	Histidine kinase
Tchl_RS05650	COG0577	efflux transmembrane transporter activity
Tchl_RS05650	COG1136	(ABC) transporter
Tchl_RS05660	COG2814	Major facilitator Superfamily
Tchl_RS05670	COG2813	Specifically methylates the guanine in position
Tchl_RS05670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tchl_RS05675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tchl_RS05685	COG2022	thiamine diphosphate biosynthetic process
Tchl_RS05690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Tchl_RS05695	COG0616	signal peptide processing
Tchl_RS05700	COG1881	PFAM PEBP family protein
Tchl_RS05725	COG1629	transport
Tchl_RS05745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tchl_RS05750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tchl_RS05755	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Tchl_RS05765	COG1561	YicC-like family, N-terminal region
Tchl_RS05795	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Tchl_RS05800	COG0826	peptidase U32
Tchl_RS05810	COG0004	ammonium transporteR
Tchl_RS05815	COG0583	DNA-binding transcription factor activity
Tchl_RS05820	COG2814	Major facilitator Superfamily
Tchl_RS05835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tchl_RS05840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tchl_RS05850	COG2860	membrane
Tchl_RS05860	COG3284	Transcriptional regulator
Tchl_RS05865	COG1012	belongs to the aldehyde dehydrogenase family
Tchl_RS05870	COG1454	alcohol dehydrogenase
Tchl_RS05885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tchl_RS05900	COG0513	Belongs to the DEAD box helicase family
Tchl_RS05915	COG1012	belongs to the aldehyde dehydrogenase family
Tchl_RS05930	COG0309	Hydrogenase expression formation protein (HypE)
Tchl_RS05935	COG0409	Hydrogenase expression formation protein
Tchl_RS05940	COG0298	carbon dioxide binding
Tchl_RS05945	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Tchl_RS05960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tchl_RS05965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tchl_RS05990	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Tchl_RS05990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Tchl_RS06000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tchl_RS06010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Tchl_RS06010	COG2755	lipolytic protein G-D-S-L family
Tchl_RS06015	COG2192	nodulation
Tchl_RS06025	COG0438	transferase activity, transferring glycosyl groups
Tchl_RS06030	COG0110	maltose O-acetyltransferase activity
Tchl_RS06035	COG2226	methyltransferase
Tchl_RS06045	COG1132	(ABC) transporter
Tchl_RS06050	COG3642	lipopolysaccharide core region biosynthetic process
Tchl_RS06060	COG1368	sulfuric ester hydrolase activity
Tchl_RS06070	COG2194	sulfuric ester hydrolase activity
Tchl_RS06075	COG0642	Histidine kinase
Tchl_RS06100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tchl_RS06115	COG0438	transferase activity, transferring glycosyl groups
Tchl_RS06120	COG0859	PFAM glycosyl transferase family 9
Tchl_RS06130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tchl_RS06140	COG0406	alpha-ribazole phosphatase activity
Tchl_RS06165	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Tchl_RS06175	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tchl_RS06180	COG4636	protein conserved in cyanobacteria
Tchl_RS06190	COG4206	TonB-dependent receptor
Tchl_RS06195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tchl_RS06200	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Tchl_RS06210	COG1648	precorrin-2 dehydrogenase activity
Tchl_RS06210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tchl_RS06215	COG1797	cobyrinic acid a,c-diamide synthase activity
Tchl_RS06245	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Tchl_RS06275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tchl_RS06285	COG1560	Kdo2-lipid A biosynthetic process
Tchl_RS06290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tchl_RS06300	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Tchl_RS06305	COG2255	four-way junction helicase activity
Tchl_RS06310	COG0632	four-way junction helicase activity
Tchl_RS06325	COG1530	ribonuclease E activity
Tchl_RS06330	COG0424	maF-like protein
Tchl_RS06335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Tchl_RS06340	COG0799	negative regulation of ribosome biogenesis
Tchl_RS06345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tchl_RS06360	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Tchl_RS06380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tchl_RS06380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tchl_RS06390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_RS06395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tchl_RS06405	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Tchl_RS06410	COG0523	cobalamin synthesis protein
Tchl_RS06430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tchl_RS06450	COG0653	protein targeting
Tchl_RS06480	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tchl_RS06510	COG0842	Transport permease protein
Tchl_RS06515	COG0842	Transport permease protein
Tchl_RS06520	COG1131	(ABC) transporter
Tchl_RS06530	COG1309	transcriptional regulator
Tchl_RS06540	COG1739	Uncharacterized protein family UPF0029
Tchl_RS06555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tchl_RS06570	COG2204	response regulator
Tchl_RS06580	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_RS06600	COG1611	Belongs to the LOG family
Tchl_RS06605	COG2267	carboxylic ester hydrolase activity
Tchl_RS06610	COG3012	SEC-C Motif Domain Protein
Tchl_RS06615	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tchl_RS06635	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Tchl_RS06660	COG3647	Membrane
Tchl_RS06665	COG3189	MarR family transcriptional regulator
Tchl_RS06670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tchl_RS06680	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_RS06685	COG0827	DNA restriction-modification system
Tchl_RS06685	COG0732	type I restriction modification DNA specificity domain
Tchl_RS06700	COG2226	methyltransferase
Tchl_RS06705	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Tchl_RS06705	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Tchl_RS06705	COG0506	proline dehydrogenase activity
Tchl_RS06710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tchl_RS06720	COG0189	ligase activity
Tchl_RS06735	COG0697	spore germination
Tchl_RS06750	COG0488	(ABC) transporter
Tchl_RS06775	COG4191	Histidine kinase
Tchl_RS06780	COG2204	response regulator
Tchl_RS06820	COG0004	ammonium transporteR
Tchl_RS06825	COG0347	Belongs to the P(II) protein family
Tchl_RS06855	COG2814	Major facilitator Superfamily
Tchl_RS06900	COG3781	membrane
Tchl_RS06910	COG0604	alcohol dehydrogenase
Tchl_RS06910	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_RS06910	COG3321	synthase
Tchl_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_RS06920	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_RS06940	COG1024	Enoyl-CoA hydratase
Tchl_RS06945	COG1881	PFAM PEBP family protein
Tchl_RS06950	COG4115	mRNA cleavage
Tchl_RS06955	COG2161	toxin-antitoxin pair type II binding
Tchl_RS06980	COG2814	Major facilitator Superfamily
Tchl_RS07075	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tchl_RS07085	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Tchl_RS07090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tchl_RS07095	COG3876	Protein conserved in bacteria
Tchl_RS07115	COG0668	transmembrane transport
Tchl_RS07130	COG0659	secondary active sulfate transmembrane transporter activity
Tchl_RS07140	COG0180	Tryptophanyl-tRNA synthetase
Tchl_RS07150	COG0583	DNA-binding transcription factor activity
Tchl_RS07175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tchl_RS07180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tchl_RS07185	COG1024	Enoyl-CoA hydratase
Tchl_RS07195	COG1368	sulfuric ester hydrolase activity
Tchl_RS07230	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tchl_RS07235	COG1518	maintenance of DNA repeat elements
Tchl_RS07270	COG0583	DNA-binding transcription factor activity
Tchl_RS07300	COG2084	Dehydrogenase
Tchl_RS07305	COG0006	proline dipeptidase activity
Tchl_RS07310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_RS07320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Tchl_RS07320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Tchl_RS07325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_RS07340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tchl_RS07355	COG0523	cobalamin synthesis protein
Tchl_RS07360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Tchl_RS07370	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tchl_RS07375	COG0583	DNA-binding transcription factor activity
Tchl_RS07480	COG2409	Drug exporters of the RND superfamily
Tchl_RS07490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tchl_RS07495	COG2814	Major facilitator Superfamily
Tchl_RS07505	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Tchl_RS07515	COG3447	MASE1 domain protein
Tchl_RS07515	COG5001	Diguanylate cyclase
Tchl_RS07515	COG5002	protein histidine kinase activity
Tchl_RS07520	COG0708	Exodeoxyribonuclease III
Tchl_RS07525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tchl_RS07555	COG0037	tRNA processing
Tchl_RS07560	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_RS07570	COG0840	transmembrane signaling receptor activity
Tchl_RS07580	COG0625	glutathione transferase activity
Tchl_RS07585	COG0617	tRNA 3'-terminal CCA addition
Tchl_RS07595	COG0702	epimerase
Tchl_RS07605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Tchl_RS07610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Tchl_RS07615	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Tchl_RS07625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Tchl_RS07630	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Tchl_RS07635	COG1137	ATPase activity
Tchl_RS07640	COG2137	regulation of response to DNA damage stimulus
Tchl_RS07645	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tchl_RS07650	COG1546	Belongs to the CinA family
Tchl_RS07655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Tchl_RS07660	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Tchl_RS07665	COG3154	lipid carrier protein
Tchl_RS07670	COG0826	peptidase U32
Tchl_RS07675	COG0826	peptidase U32
Tchl_RS07685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tchl_RS07690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tchl_RS07695	COG0018	arginyl-trna synthetase
Tchl_RS07705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tchl_RS07725	COG3243	poly(R)-hydroxyalkanoic acid synthase
Tchl_RS07735	COG1960	acyl-CoA dehydrogenase activity
Tchl_RS07760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tchl_RS07765	COG1024	Enoyl-CoA hydratase
Tchl_RS07780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_RS07795	COG4948	Mandelate Racemase Muconate Lactonizing
Tchl_RS07800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tchl_RS07805	COG1309	transcriptional regulator
Tchl_RS07810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tchl_RS07825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tchl_RS07830	COG1132	(ABC) transporter
Tchl_RS07835	COG1404	Belongs to the peptidase S8 family
Tchl_RS07855	COG0604	alcohol dehydrogenase
Tchl_RS07860	COG0183	Belongs to the thiolase family
Tchl_RS07890	COG0439	Biotin carboxylase
Tchl_RS07895	COG0511	ligase activity, forming carbon-carbon bonds
Tchl_RS07905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tchl_RS07950	COG1012	belongs to the aldehyde dehydrogenase family
Tchl_RS07970	COG2204	response regulator
Tchl_RS07980	COG1115	amino acid carrier protein
Tchl_RS07985	COG1660	Displays ATPase and GTPase activities
Tchl_RS08000	COG0412	Dienelactone hydrolase
Tchl_RS08005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tchl_RS08015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Tchl_RS08020	COG0602	queuosine metabolic process
Tchl_RS08035	COG0823	Involved in the tonB-independent uptake of proteins
Tchl_RS08055	COG0824	Thioesterase
Tchl_RS08060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tchl_RS08065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Tchl_RS08080	COG4969	Belongs to the N-Me-Phe pilin family
Tchl_RS08110	COG0330	HflC and HflK could
Tchl_RS08145	COG4774	siderophore transport
Tchl_RS08180	COG1595	DNA-templated transcription, initiation
Tchl_RS08185	COG0659	secondary active sulfate transmembrane transporter activity
Tchl_RS08190	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_RS08195	COG0784	Response regulator, receiver
Tchl_RS08195	COG4191	Histidine kinase
Tchl_RS08210	COG4772	TonB-dependent receptor
Tchl_RS08215	COG1538	Outer membrane efflux protein
Tchl_RS08220	COG1136	(ABC) transporter
Tchl_RS08220	COG0577	efflux transmembrane transporter activity
Tchl_RS08225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_RS08285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tchl_RS08290	COG3132	Protein of unknown function, DUF480
Tchl_RS08295	COG0129	dihydroxy-acid dehydratase activity
Tchl_RS08325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tchl_RS08325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Tchl_RS08340	COG0745	RESPONSE REGULATOR receiver
Tchl_RS08345	COG2205	protein histidine kinase activity
Tchl_RS08360	COG0730	response to heat
Tchl_RS08375	COG1121	(ABC) transporter
Tchl_RS08380	COG0735	belongs to the Fur family
Tchl_RS08390	COG0577	efflux transmembrane transporter activity
Tchl_RS08390	COG1136	(ABC) transporter
Tchl_RS08410	COG1215	transferase activity, transferring glycosyl groups
Tchl_RS08415	COG2274	protein secretion by the type I secretion system
Tchl_RS08420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_RS08425	COG2197	response regulator
Tchl_RS08440	COG3706	GGDEF domain
Tchl_RS08455	COG1024	Enoyl-CoA hydratase
Tchl_RS08465	COG1253	flavin adenine dinucleotide binding
Tchl_RS08470	COG1802	Transcriptional regulator
Tchl_RS08475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tchl_RS08475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tchl_RS08480	COG1703	isobutyryl-CoA mutase activity
Tchl_RS08485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tchl_RS08490	COG4770	biotin carboxylase activity
Tchl_RS08495	COG1509	lysine 2,3-aminomutase activity
Tchl_RS08510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tchl_RS08510	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tchl_RS08510	COG1703	isobutyryl-CoA mutase activity
Tchl_RS08535	COG4566	intracellular signal transduction
Tchl_RS08545	COG2201	protein-glutamate methylesterase activity
Tchl_RS08575	COG4964	Belongs to the GSP D family
Tchl_RS08600	COG2894	cell division
Tchl_RS08630	COG0784	Response regulator, receiver
Tchl_RS08630	COG2205	protein histidine kinase activity
Tchl_RS08630	COG2198	Histidine kinase
Tchl_RS08635	COG2197	response regulator
Tchl_RS08640	COG0277	FAD linked oxidase domain protein
Tchl_RS08660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tchl_RS08670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tchl_RS08680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tchl_RS08685	COG0081	regulation of translation
Tchl_RS08690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tchl_RS08695	COG0222	ribosome binding
Tchl_RS08700	COG0085	RNA polymerase activity
Tchl_RS08705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tchl_RS08710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tchl_RS08715	COG0049	tRNA binding
Tchl_RS08720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tchl_RS08725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tchl_RS08730	COG0051	transcription antitermination factor activity, RNA binding
Tchl_RS08735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tchl_RS08740	COG0088	Forms part of the polypeptide exit tunnel
Tchl_RS08745	COG0089	rRNA binding
Tchl_RS08750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tchl_RS08755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tchl_RS08760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tchl_RS08765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tchl_RS08770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tchl_RS08775	COG0255	Belongs to the universal ribosomal protein uL29 family
Tchl_RS08780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tchl_RS08785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tchl_RS08790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tchl_RS08795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tchl_RS08800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tchl_RS08805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tchl_RS08810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tchl_RS08815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tchl_RS08820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tchl_RS08825	COG1841	ribosomal large subunit assembly
Tchl_RS08830	COG0200	Binds to the 23S rRNA
Tchl_RS08835	COG0201	protein transport
Tchl_RS08840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tchl_RS08845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tchl_RS08850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tchl_RS08855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tchl_RS08860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tchl_RS08865	COG0202	RNA polymerase activity
Tchl_RS08870	COG0203	ribosomal protein L17
Tchl_RS08875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tchl_RS08885	COG2814	Major facilitator Superfamily
Tchl_RS08890	COG0629	single-stranded DNA binding
Tchl_RS08900	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Tchl_RS08925	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Tchl_RS08935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Tchl_RS08945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tchl_RS08950	COG2084	Dehydrogenase
Tchl_RS08955	COG2084	Dehydrogenase
Tchl_RS08985	COG1857	crispr-associated protein
Tchl_RS08995	COG1518	maintenance of DNA repeat elements
Tchl_RS09000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tchl_RS09005	COG4372	Transposase
Tchl_RS09020	COG4584	PFAM Integrase catalytic
Tchl_RS09025	COG1484	DNA-dependent DNA replication
Tchl_RS09035	COG0235	Class ii aldolase
Tchl_RS09040	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tchl_RS09045	COG0436	Aminotransferase
Tchl_RS09085	COG2151	metal-sulfur cluster biosynthetic enzyme
Tchl_RS09090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tchl_RS09110	COG0071	Belongs to the small heat shock protein (HSP20) family
Tchl_RS09125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Tchl_RS09130	COG0165	Argininosuccinate lyase
Tchl_RS09140	COG0181	hydroxymethylbilane synthase activity
Tchl_RS09150	COG2959	enzyme of heme biosynthesis
Tchl_RS09160	COG0408	coproporphyrinogen oxidase activity
Tchl_RS09170	COG0151	Belongs to the GarS family
Tchl_RS09175	COG0138	bifunctional purine biosynthesis protein purh
Tchl_RS09180	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Tchl_RS09190	COG0659	secondary active sulfate transmembrane transporter activity
Tchl_RS09195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tchl_RS09195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tchl_RS09205	COG0489	protein tyrosine kinase activity
Tchl_RS09210	COG0717	Belongs to the dCTP deaminase family
Tchl_RS09225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Tchl_RS09260	COG3093	addiction module antidote protein HigA
Tchl_RS09270	COG0582	viral genome integration into host DNA
Tchl_RS09285	COG0488	(ABC) transporter
Tchl_RS09290	COG0604	alcohol dehydrogenase
Tchl_RS09295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tchl_RS09300	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tchl_RS09305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tchl_RS09310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tchl_RS09315	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tchl_RS09325	COG0277	FAD linked oxidase domain protein
Tchl_RS09330	COG0277	FAD linked oxidase domain protein
Tchl_RS09335	COG0247	lactate metabolic process
Tchl_RS09340	COG0631	protein serine/threonine phosphatase activity
Tchl_RS09350	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Tchl_RS09360	COG0513	Belongs to the DEAD box helicase family
Tchl_RS09365	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Tchl_RS09370	COG0667	Aldo Keto reductase
Tchl_RS09375	COG1653	transport
Tchl_RS09380	COG0142	geranyltranstransferase activity
Tchl_RS09390	COG0183	Belongs to the thiolase family
Tchl_RS09395	COG0435	Glutathione S-transferase
Tchl_RS09400	COG2353	YceI-like domain
Tchl_RS09410	COG3038	cytochrome b561
Tchl_RS09420	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Tchl_RS09425	COG1074	ATP-dependent DNA helicase activity
Tchl_RS09430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tchl_RS09435	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tchl_RS09440	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tchl_RS09440	COG1902	pentaerythritol trinitrate reductase activity
Tchl_RS09470	COG1703	isobutyryl-CoA mutase activity
Tchl_RS09475	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Tchl_RS09480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tchl_RS09495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tchl_RS09515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tchl_RS09515	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tchl_RS09525	COG1960	acyl-CoA dehydrogenase activity
Tchl_RS09550	COG1802	Transcriptional regulator
Tchl_RS09555	COG0163	prenyltransferase activity
Tchl_RS09565	COG2414	aldehyde ferredoxin oxidoreductase
Tchl_RS09570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tchl_RS09590	COG0840	transmembrane signaling receptor activity
Tchl_RS09600	COG0745	RESPONSE REGULATOR receiver
Tchl_RS09610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tchl_RS09615	COG2205	protein histidine kinase activity
Tchl_RS09615	COG3437	response regulator, receiver
Tchl_RS09615	COG3850	Histidine kinase
Tchl_RS09615	COG4999	Histidine kinase
Tchl_RS09630	COG0315	cyclic pyranopterin monophosphate synthase activity
Tchl_RS09665	COG4372	Transposase
Tchl_RS09705	COG0315	cyclic pyranopterin monophosphate synthase activity
Tchl_RS09710	COG4783	chaperone-mediated protein folding
Tchl_RS09715	COG0425	Belongs to the sulfur carrier protein TusA family
Tchl_RS09720	COG0525	valine-tRNA ligase activity
Tchl_RS09735	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tchl_RS09740	COG0795	lipopolysaccharide-transporting ATPase activity
Tchl_RS09745	COG0795	lipopolysaccharide-transporting ATPase activity
Tchl_RS09750	COG0335	large ribosomal subunit rRNA binding
Tchl_RS09755	COG0336	Belongs to the RNA methyltransferase TrmD family
Tchl_RS09760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tchl_RS09765	COG0228	four-way junction DNA binding
Tchl_RS09780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tchl_RS09785	COG1183	phosphatidylcholine synthase activity
Tchl_RS09790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tchl_RS09795	COG0440	acetolactate synthase activity
Tchl_RS09800	COG0028	Belongs to the TPP enzyme family
Tchl_RS09825	COG0308	aminopeptidase N
Tchl_RS09830	COG0517	IMP dehydrogenase activity
Tchl_RS09830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Tchl_RS09835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Tchl_RS09840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tchl_RS09855	COG0617	tRNA 3'-terminal CCA addition
Tchl_RS09865	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tchl_RS09870	COG0628	permease
Tchl_RS09875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tchl_RS09885	COG0582	viral genome integration into host DNA
Tchl_RS09925	COG1403	HNH endonuclease
Tchl_RS09935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tchl_RS09980	COG1525	nuclease
Tchl_RS10040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tchl_RS10045	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tchl_RS10050	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tchl_RS10065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Tchl_RS10070	COG4974	Belongs to the 'phage' integrase family
Tchl_RS10080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tchl_RS10085	COG1466	dna polymerase III delta subunit
Tchl_RS10095	COG0495	leucyl-tRNA aminoacylation
Tchl_RS10105	COG0210	DNA helicase
Tchl_RS10110	COG1192	Involved in chromosome partitioning
Tchl_RS10115	COG0281	malic enzyme
Tchl_RS10115	COG0280	phosphate acetyltransferase
Tchl_RS10130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tchl_RS10135	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Tchl_RS10140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tchl_RS10145	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Tchl_RS10160	COG0006	proline dipeptidase activity
Tchl_RS10165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tchl_RS10175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tchl_RS10205	COG2223	nitrite transmembrane transporter activity
Tchl_RS10210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tchl_RS10220	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tchl_RS10225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tchl_RS10230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tchl_RS10235	COG0215	cysteine-tRNA ligase activity
Tchl_RS10245	COG0484	heat shock protein binding
Tchl_RS10250	COG0443	Heat shock 70 kDa protein
Tchl_RS10255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tchl_RS10265	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Tchl_RS10275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tchl_RS10280	COG0287	Prephenate dehydrogenase
Tchl_RS10285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tchl_RS10295	COG0776	regulation of translation
Tchl_RS10305	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Tchl_RS10335	COG2261	transglycosylase associated protein
Tchl_RS10345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tchl_RS10350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tchl_RS10355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tchl_RS10360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tchl_RS10365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tchl_RS10370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tchl_RS10370	COG0072	phenylalanine-tRNA ligase activity
Tchl_RS10375	COG0776	regulation of translation
Tchl_RS10390	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tchl_RS10395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tchl_RS10405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tchl_RS10415	COG2951	lytic endotransglycosylase activity
Tchl_RS10430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tchl_RS10435	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Tchl_RS10445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tchl_RS10485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_RS10495	COG0011	TIGRFAM Protein of
Tchl_RS10515	COG1012	belongs to the aldehyde dehydrogenase family
Tchl_RS10520	COG1024	Enoyl-CoA hydratase
Tchl_RS10535	COG3396	Phenylacetate-CoA oxygenase
Tchl_RS10540	COG3460	Phenylacetate-CoA oxygenase
Tchl_RS10545	COG3396	Phenylacetate-CoA oxygenase
Tchl_RS10550	COG2151	metal-sulfur cluster biosynthetic enzyme
Tchl_RS10555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tchl_RS10560	COG1309	transcriptional regulator
Tchl_RS10565	COG0183	Belongs to the thiolase family
Tchl_RS10570	COG0789	Transcriptional regulator
Tchl_RS10590	COG4658	electron transport chain
Tchl_RS10595	COG4656	Part of a membrane complex involved in electron transport
Tchl_RS10600	COG2878	Part of a membrane complex involved in electron transport
Tchl_RS10605	COG4657	Part of a membrane complex involved in electron transport
Tchl_RS10620	COG0826	peptidase U32
Tchl_RS10725	COG0437	4 iron, 4 sulfur cluster binding
Tchl_RS10730	COG0243	molybdopterin cofactor binding
Tchl_RS10735	COG0517	IMP dehydrogenase activity
Tchl_RS10745	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tchl_RS10750	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tchl_RS10750	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tchl_RS10790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tchl_RS10845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Tchl_RS10845	COG0456	acetyltransferase
Tchl_RS10865	COG2902	Dehydrogenase
Tchl_RS10870	COG0504	CTP synthase activity
Tchl_RS10875	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Tchl_RS10880	COG0148	phosphopyruvate hydratase activity
Tchl_RS10885	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Tchl_RS10890	COG0791	NLP P60 protein
Tchl_RS10905	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Tchl_RS10910	COG0306	phosphate transporter
Tchl_RS10920	COG0302	gtp cyclohydrolase
Tchl_RS10940	COG0513	Belongs to the DEAD box helicase family
Tchl_RS10945	COG1278	Cold shock
Tchl_RS10950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Tchl_RS10955	COG0613	PHP domain protein
Tchl_RS10960	COG0009	L-threonylcarbamoyladenylate synthase
Tchl_RS10965	COG1994	Peptidase M50
Tchl_RS10970	COG0180	Tryptophanyl-tRNA synthetase
Tchl_RS10975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Tchl_RS10980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tchl_RS10990	COG0779	Required for maturation of 30S ribosomal subunits
Tchl_RS10995	COG2251	uridine kinase activity
Tchl_RS10995	COG0195	Participates in both transcription termination and antitermination
Tchl_RS11000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tchl_RS11005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tchl_RS11010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tchl_RS11015	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tchl_RS11020	COG1185	polyribonucleotide nucleotidyltransferase activity
Tchl_RS11025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tchl_RS11090	COG0822	iron-sulfur transferase activity
Tchl_RS11095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tchl_RS11100	COG0719	Fe-S assembly protein
Tchl_RS11105	COG0396	ATPase activity
Tchl_RS11110	COG0719	Fe-S assembly protein
Tchl_RS11130	COG4251	negative regulation of phosphorylation
Tchl_RS11135	COG0625	glutathione transferase activity
Tchl_RS11145	COG4691	Plasmid stability protein
Tchl_RS11155	COG2363	Small membrane protein
Tchl_RS11160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Tchl_RS11180	COG2205	protein histidine kinase activity
Tchl_RS11180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tchl_RS11185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tchl_RS11190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tchl_RS11190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Tchl_RS11195	COG2354	Protein conserved in bacteria
Tchl_RS11200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tchl_RS11205	COG1196	nuclear chromosome segregation
Tchl_RS11210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tchl_RS11240	COG2188	Transcriptional regulator
Tchl_RS11250	COG1116	anion transmembrane transporter activity
Tchl_RS11255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tchl_RS11265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tchl_RS11275	COG3314	Sporulation integral membrane protein YlbJ
Tchl_RS11280	COG0010	Belongs to the arginase family
Tchl_RS11285	COG1228	amidohydrolase
Tchl_RS11290	COG0583	DNA-binding transcription factor activity
Tchl_RS11295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tchl_RS11315	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Tchl_RS11320	COG1984	allophanate hydrolase subunit 2
Tchl_RS11325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Tchl_RS11335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_RS11350	COG0583	DNA-binding transcription factor activity
Tchl_RS11355	COG1760	l-serine dehydratase
Tchl_RS11360	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Tchl_RS11365	COG3047	cAMP biosynthetic process
Tchl_RS11385	COG1032	radical SAM domain protein
Tchl_RS11405	COG1136	(ABC) transporter
Tchl_RS11410	COG0658	competence protein
Tchl_RS11410	COG2333	competence protein COMEC
Tchl_RS11425	COG0501	Belongs to the peptidase M48B family
Tchl_RS11430	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Tchl_RS11440	COG0254	rRNA binding
Tchl_RS11455	COG3012	SEC-C Motif Domain Protein
Tchl_RS11455	COG3318	Belongs to the UPF0149 family
Tchl_RS11465	COG0727	PFAM Uncharacterised protein family (UPF0153)
Tchl_RS11475	COG2501	S4 domain
Tchl_RS11495	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Tchl_RS11505	COG3177	Filamentation induced by cAMP protein fic
Tchl_RS11515	COG0739	heme binding
Tchl_RS11515	COG0741	lytic transglycosylase activity
Tchl_RS11515	COG1196	nuclear chromosome segregation
Tchl_RS11520	COG2197	response regulator
Tchl_RS11545	COG2165	general secretion pathway protein
Tchl_RS11580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Tchl_RS11590	COG2165	general secretion pathway protein
Tchl_RS11600	COG0039	L-malate dehydrogenase activity
Tchl_RS11605	COG2188	Transcriptional regulator
Tchl_RS11620	COG1053	succinate dehydrogenase
Tchl_RS11625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Tchl_RS11630	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Tchl_RS11635	COG0372	Belongs to the citrate synthase family
Tchl_RS11640	COG0567	Dehydrogenase, E1 component
Tchl_RS11645	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tchl_RS11650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tchl_RS11655	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Tchl_RS11660	COG1199	ATP-dependent helicase activity
Tchl_RS11665	COG1763	Mo-molybdopterin cofactor biosynthetic process
Tchl_RS11670	COG0303	'Molybdopterin
Tchl_RS11675	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Tchl_RS11680	COG0314	molybdopterin synthase activity
Tchl_RS11705	COG0471	metal ion transport
Tchl_RS11705	COG3273	potassium ion transport
Tchl_RS11715	COG0657	acetylesterase activity
Tchl_RS11725	COG1376	ErfK ybiS ycfS ynhG family protein
Tchl_RS11735	COG0354	folic acid binding
Tchl_RS11740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Tchl_RS11745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tchl_RS11760	COG0084	hydrolase, TatD family'
Tchl_RS11770	COG0641	radical SAM
Tchl_RS11775	COG1414	Transcriptional regulator
Tchl_RS11800	COG2207	Transcriptional regulator
Tchl_RS11805	COG2807	transmembrane transport
Tchl_RS11840	COG2824	Alkylphosphonate utilization operon protein PhnA
Tchl_RS11845	COG1473	amidohydrolase
Tchl_RS11850	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Tchl_RS11870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tchl_RS11875	COG1067	ATP-dependent peptidase activity
Tchl_RS11910	COG0556	nucleotide-excision repair
Tchl_RS11915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tchl_RS11920	COG1530	ribonuclease E activity
Tchl_RS11930	COG0564	pseudouridine synthase activity
Tchl_RS11940	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tchl_RS11945	COG0424	maF-like protein
Tchl_RS11950	COG1399	metal-binding, possibly nucleic acid-binding protein
Tchl_RS11955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tchl_RS11960	COG0416	fatty acid biosynthetic process
Tchl_RS11965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tchl_RS11980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tchl_RS11995	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tchl_RS12020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tchl_RS12030	COG0481	GTPase activity
Tchl_RS12035	COG0681	Belongs to the peptidase S26 family
Tchl_RS12045	COG0571	ribonuclease III activity
Tchl_RS12050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tchl_RS12055	COG1381	Involved in DNA repair and RecF pathway recombination
Tchl_RS12060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Tchl_RS12065	COG0736	holo-[acyl-carrier-protein] synthase activity
Tchl_RS12070	COG1472	Belongs to the glycosyl hydrolase 3 family
Tchl_RS12075	COG0322	excinuclease ABC activity
Tchl_RS12095	COG0501	Belongs to the peptidase M48B family
Tchl_RS12100	COG1704	LemA family
Tchl_RS12105	COG1242	4 iron, 4 sulfur cluster binding
Tchl_RS12170	COG4453	Protein conserved in bacteria
Tchl_RS12250	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tchl_RS12285	COG0789	Transcriptional regulator
Tchl_RS12365	COG2816	NAD+ diphosphatase activity
Tchl_RS12375	COG4771	TonB-dependent receptor
Tchl_RS12405	COG3437	response regulator, receiver
Tchl_RS12430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Tchl_RS12435	COG1469	GTP cyclohydrolase I activity
Tchl_RS12440	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tchl_RS12445	COG0142	geranyltranstransferase activity
Tchl_RS12450	COG1722	exodeoxyribonuclease VII activity
Tchl_RS12460	COG3411	Ferredoxin
Tchl_RS12465	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tchl_RS12470	COG1047	Peptidyl-prolyl cis-trans
Tchl_RS12475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tchl_RS12480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tchl_RS12485	COG0196	riboflavin kinase activity
Tchl_RS12490	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tchl_RS12495	COG0802	atpase or kinase
Tchl_RS12500	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tchl_RS12505	COG2900	Belongs to the SlyX family
Tchl_RS12510	COG3045	CreA protein
Tchl_RS12515	COG3033	Beta-eliminating lyase
Tchl_RS12550	COG0826	peptidase U32
Tchl_RS12560	COG2133	pyrroloquinoline quinone binding
Tchl_RS12570	COG3108	Peptidase M15
Tchl_RS12575	COG2989	Protein conserved in bacteria
Tchl_RS12605	COG0697	spore germination
Tchl_RS12610	COG0488	(ABC) transporter
Tchl_RS12620	COG0583	DNA-binding transcription factor activity
Tchl_RS12630	COG0268	Binds directly to 16S ribosomal RNA
Tchl_RS12640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tchl_RS12645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tchl_RS12650	COG0137	argininosuccinate synthase activity
Tchl_RS12660	COG3123	guanosine phosphorylase activity
Tchl_RS12665	COG1666	GTP binding
Tchl_RS12695	COG4969	Belongs to the N-Me-Phe pilin family
Tchl_RS12705	COG0494	nUDIX hydrolase
Tchl_RS12715	COG0183	Belongs to the thiolase family
Tchl_RS12720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tchl_RS12730	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Tchl_RS12750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tchl_RS12760	COG5002	protein histidine kinase activity
Tchl_RS12765	COG0745	RESPONSE REGULATOR receiver
Tchl_RS12770	COG2176	DNA-directed DNA polymerase activity
Tchl_RS12770	COG5002	protein histidine kinase activity
Tchl_RS12775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tchl_RS12785	COG0542	response to heat
Tchl_RS12810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tchl_RS12815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Tchl_RS12835	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Tchl_RS12840	COG1140	nitrate reductase beta subunit
Tchl_RS12845	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Tchl_RS12850	COG2181	nitrate reductase activity
Tchl_RS12855	COG3850	Histidine kinase
Tchl_RS12860	COG2197	response regulator
Tchl_RS12875	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tchl_RS12885	COG2914	Belongs to the UPF0125 (RnfH) family
Tchl_RS12895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tchl_RS12895	COG0519	Catalyzes the synthesis of GMP from XMP
Tchl_RS12920	COG4974	Belongs to the 'phage' integrase family
Tchl_RS12925	COG0582	viral genome integration into host DNA
Tchl_RS12930	COG4974	Belongs to the 'phage' integrase family
Tchl_RS12955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tchl_RS12980	COG4680	protein conserved in bacteria
Tchl_RS12995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tchl_RS12995	COG1648	precorrin-2 dehydrogenase activity
Tchl_RS13000	COG2010	Cytochrome c
Tchl_RS13045	COG0535	radical SAM domain protein
Tchl_RS13075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tchl_RS13095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tchl_RS13105	COG2010	Cytochrome c
Tchl_RS13115	COG0167	dihydroorotate dehydrogenase activity
Tchl_RS13120	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Tchl_RS13125	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Tchl_RS13130	COG3842	ATPase activity
Tchl_RS13135	COG1178	ABC-type Fe3 transport system permease component
Tchl_RS13140	COG1840	ABC-type Fe3 transport system, periplasmic component
Tchl_RS13150	COG0791	NLP P60 protein
Tchl_RS13165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Tchl_RS13170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tchl_RS13180	COG0436	Aminotransferase
Tchl_RS13190	COG2258	MOSC domain
Tchl_RS13195	COG3360	Dodecin
Tchl_RS13205	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Tchl_RS13215	COG0850	regulation of cytokinetic process
Tchl_RS13220	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Tchl_RS13225	COG1393	Belongs to the ArsC family
Tchl_RS13230	COG2183	response to ionizing radiation
Tchl_RS13240	COG1042	CoA-binding domain protein
Tchl_RS13240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tchl_RS13240	COG0045	succinate-CoA ligase (ADP-forming) activity
Tchl_RS13250	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Tchl_RS13265	COG4181	ATPase activity
Tchl_RS13270	COG0560	Phosphoserine phosphatase
Tchl_RS13275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tchl_RS13280	COG0519	Catalyzes the synthesis of GMP from XMP
Tchl_RS13285	COG0346	lactoylglutathione lyase activity
Tchl_RS13305	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Tchl_RS13315	COG2078	PFAM AMMECR1 domain protein
Tchl_RS13320	COG1355	regulation of microtubule-based process
Tchl_RS13325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tchl_RS13330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tchl_RS13335	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Tchl_RS13345	COG3228	Belongs to the MtfA family
Tchl_RS13350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tchl_RS13355	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Tchl_RS13360	COG0248	Ppx GppA phosphatase
Tchl_RS13365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tchl_RS13370	COG1127	ABC transporter
Tchl_RS13385	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_RS13390	COG0084	hydrolase, TatD family'
Tchl_RS13410	COG1960	acyl-CoA dehydrogenase activity
Tchl_RS13415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tchl_RS13425	COG2350	Protein conserved in bacteria
Tchl_RS13430	COG2917	probably involved in intracellular septation
Tchl_RS13450	COG1214	PFAM Peptidase M22, glycoprotease
Tchl_RS13460	COG1573	uracil-dna glycosylase
Tchl_RS13465	COG0477	Major facilitator Superfamily
Tchl_RS13480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Tchl_RS13480	COG0512	Glutamine amidotransferase of anthranilate synthase
Tchl_RS13490	COG3259	Nickel-dependent hydrogenase
Tchl_RS13505	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tchl_RS13520	COG0628	permease
Tchl_RS13525	COG3162	membrane
Tchl_RS13545	COG3174	membrane
Tchl_RS13550	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tchl_RS13555	COG2814	Major facilitator Superfamily
Tchl_RS13570	COG5012	cobalamin binding
Tchl_RS13575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tchl_RS13655	COG2226	methyltransferase
Tchl_RS13670	COG1595	DNA-templated transcription, initiation
Tchl_RS13700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Tchl_RS13705	COG0438	transferase activity, transferring glycosyl groups
Tchl_RS13710	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Tchl_RS13715	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Tchl_RS13720	COG3639	organic phosphonate transmembrane transporter activity
Tchl_RS13725	COG3639	organic phosphonate transmembrane transporter activity
Tchl_RS13775	COG1136	(ABC) transporter
Tchl_RS13780	COG0861	Integral membrane protein TerC family
Tchl_RS13785	COG1562	ergosterol biosynthetic process
Tchl_RS13790	COG1562	ergosterol biosynthetic process
Tchl_RS13795	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
Tchl_RS13810	COG1702	phosphate starvation-inducible protein PhoH
Tchl_RS13815	COG2866	Carboxypeptidase
Tchl_RS13820	COG3022	response to hydroperoxide
Tchl_RS13835	COG0156	8-amino-7-oxononanoate synthase activity
Tchl_RS13840	COG2267	carboxylic ester hydrolase activity
Tchl_RS13845	COG2226	methyltransferase
Tchl_RS13850	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Tchl_RS13855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tchl_RS13860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tchl_RS13865	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tchl_RS13870	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tchl_RS13875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tchl_RS13880	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Tchl_RS13900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tchl_RS13905	COG0575	Belongs to the CDS family
Tchl_RS13910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tchl_RS13915	COG0233	cytoplasmic translational termination
Tchl_RS13920	COG0528	UMP kinase activity
Tchl_RS13925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tchl_RS13930	COG0052	Belongs to the universal ribosomal protein uS2 family
Tchl_RS13935	COG0024	Methionine aminopeptidase
Tchl_RS13940	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Tchl_RS13965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tchl_RS13975	COG1196	nuclear chromosome segregation
Tchl_RS13980	COG0436	Aminotransferase
Tchl_RS13985	COG2171	N-acyltransferase activity
Tchl_RS13995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tchl_RS14015	COG0443	Heat shock 70 kDa protein
Tchl_RS14020	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Tchl_RS14030	COG0822	iron-sulfur transferase activity
Tchl_RS14035	COG1104	cysteine desulfurase activity
Tchl_RS14040	COG1104	cysteine desulfurase activity
Tchl_RS14050	COG1045	serine acetyltransferase
Tchl_RS14060	COG0483	inositol monophosphate 1-phosphatase activity
Tchl_RS14065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tchl_RS14080	COG0517	IMP dehydrogenase activity
Tchl_RS14090	COG0328	RNA-DNA hybrid ribonuclease activity
Tchl_RS14095	COG2226	methyltransferase
Tchl_RS14280	COG4197	protein conserved in bacteria, prophage-related
Tchl_RS14315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tchl_RS14350	COG1475	DNA binding
Tchl_RS14375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tchl_RS14380	COG0741	lytic transglycosylase activity
Tchl_RS14380	COG1388	LysM domain
Tchl_RS14400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tchl_RS14475	COG5002	protein histidine kinase activity
Tchl_RS14485	COG0789	Transcriptional regulator
Tchl_RS14575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tchl_RS14580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tchl_RS14585	COG0740	serine-type endopeptidase activity
Tchl_RS14590	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tchl_RS14595	COG2766	serine protein kinase
Tchl_RS14600	COG2718	Belongs to the UPF0229 family
Tchl_RS14605	COG2719	SpoVR family
Tchl_RS14610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tchl_RS14610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tchl_RS14625	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tchl_RS14635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tchl_RS14640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Tchl_RS14645	COG1674	ftsk spoiiie
Tchl_RS14655	COG0492	ferredoxin-NADP+ reductase activity
Tchl_RS14660	COG2840	Smr protein MutS2
Tchl_RS14665	COG0347	Belongs to the P(II) protein family
Tchl_RS14670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tchl_RS14670	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tchl_RS14675	COG0494	nUDIX hydrolase
Tchl_RS14680	COG1007	ATP synthesis coupled electron transport
Tchl_RS14695	COG0713	ATP synthesis coupled electron transport
Tchl_RS14705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tchl_RS14710	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tchl_RS14715	COG1034	ATP synthesis coupled electron transport
Tchl_RS14725	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Tchl_RS14730	COG0649	NAD binding
Tchl_RS14735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tchl_RS14740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tchl_RS14745	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tchl_RS14760	COG0149	triose-phosphate isomerase activity
Tchl_RS14770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tchl_RS14785	COG0798	PFAM Bile acid sodium symporter
Tchl_RS14800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tchl_RS14810	COG0573	inorganic phosphate transmembrane transporter activity
Tchl_RS14815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tchl_RS14820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tchl_RS14825	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tchl_RS14830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tchl_RS14835	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Tchl_RS14840	COG1534	Rna-binding protein
Tchl_RS14845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tchl_RS14850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tchl_RS14855	COG0505	Belongs to the CarA family
Tchl_RS14865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tchl_RS14875	COG0735	belongs to the Fur family
Tchl_RS14880	COG0497	DNA recombination
Tchl_RS14885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tchl_RS14890	COG1420	regulation of RNA biosynthetic process
Tchl_RS14895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Tchl_RS14900	COG2815	serine threonine protein kinase
Tchl_RS14900	COG0515	serine threonine protein kinase
Tchl_RS14905	COG0402	S-adenosylhomocysteine deaminase activity
Tchl_RS14915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tchl_RS14920	COG1309	transcriptional regulator
Tchl_RS14925	COG1024	Enoyl-CoA hydratase
Tchl_RS14935	COG1024	Enoyl-CoA hydratase
Tchl_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_RS14945	COG1960	acyl-CoA dehydrogenase activity
Tchl_RS14955	COG1024	Enoyl-CoA hydratase
Tchl_RS14960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_RS14970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tchl_RS14970	COG0045	succinate-CoA ligase (ADP-forming) activity
Tchl_RS14970	COG1042	CoA-binding domain protein
Tchl_RS14980	COG1139	Iron-sulfur cluster binding protein
Tchl_RS14990	COG2186	Transcriptional regulator
Tchl_RS14995	COG2951	lytic endotransglycosylase activity
Tchl_RS15000	COG0584	glycerophosphoryl diester phosphodiesterase
Tchl_RS15015	COG2204	response regulator
Tchl_RS15035	COG2358	TRAP transporter, solute receptor (TAXI family
Tchl_RS15040	COG0579	oxidoreductase
Tchl_RS15045	COG1454	alcohol dehydrogenase
Tchl_RS15055	COG1454	alcohol dehydrogenase
Tchl_RS15065	COG1137	ATPase activity
Tchl_RS15075	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tchl_RS15090	COG2204	response regulator
Tchl_RS15095	COG3852	Histidine kinase
Tchl_RS15110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tchl_RS15115	COG1960	acyl-CoA dehydrogenase activity
Tchl_RS15120	COG0583	DNA-binding transcription factor activity
Tchl_RS15165	COG0582	viral genome integration into host DNA
Tchl_RS15240	COG4372	Transposase
Tchl_RS15265	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Tchl_RS15275	COG0686	Belongs to the AlaDH PNT family
Tchl_RS15295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tchl_RS15305	COG0583	DNA-binding transcription factor activity
Tchl_RS15310	COG0583	DNA-binding transcription factor activity
Tchl_RS15315	COG0509	glycine decarboxylation via glycine cleavage system
Tchl_RS15320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tchl_RS15320	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tchl_RS15350	COG4628	conserved protein (DUF2132)
Tchl_RS15405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Tchl_RS15420	COG0789	Transcriptional regulator
Tchl_RS15440	COG4372	Transposase
Tchl_RS15455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tchl_RS15465	COG1881	PFAM PEBP family protein
Tchl_RS15470	COG2801	Transposase and inactivated derivatives
Tchl_RS15485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Tchl_RS15500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tchl_RS15510	COG0163	prenyltransferase activity
Tchl_RS15520	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Tchl_RS15525	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tchl_RS15535	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tchl_RS15555	COG0163	prenyltransferase activity
Tchl_RS15595	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tchl_RS15600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tchl_RS15615	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
Tchl_RS15620	COG2132	Multicopper oxidase
Tchl_RS15645	COG5002	protein histidine kinase activity
Tchl_RS15670	COG4628	conserved protein (DUF2132)
Tchl_RS15685	COG0251	oxidation-reduction process
Tchl_RS15690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Tchl_RS15700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Tchl_RS15705	COG0028	Belongs to the TPP enzyme family
Tchl_RS15715	COG0009	L-threonylcarbamoyladenylate synthase
Tchl_RS15720	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Tchl_RS15725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tchl_RS15730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tchl_RS15740	COG4566	intracellular signal transduction
Tchl_RS15755	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Tchl_RS15760	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tchl_RS15765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tchl_RS15785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tchl_RS15785	COG0047	phosphoribosylformylglycinamidine synthase activity
Tchl_RS15790	COG4372	Transposase
Tchl_RS15830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tchl_RS15835	COG0509	glycine decarboxylation via glycine cleavage system
Tchl_RS15840	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tchl_RS15840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tchl_RS15855	COG1215	transferase activity, transferring glycosyl groups
Tchl_RS15860	COG0471	metal ion transport
Tchl_RS15870	COG0563	adenylate kinase activity
Tchl_RS15875	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Tchl_RS15880	COG2835	tetraacyldisaccharide 4'-kinase activity
Tchl_RS15885	COG1663	tetraacyldisaccharide 4'-kinase activity
Tchl_RS15890	COG0848	biopolymer transport protein
Tchl_RS15895	COG0811	peptide transport
Tchl_RS15900	COG1570	exodeoxyribonuclease VII activity
Tchl_RS15905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Tchl_RS15915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tchl_RS15925	COG4657	Part of a membrane complex involved in electron transport
Tchl_RS15930	COG2878	Part of a membrane complex involved in electron transport
Tchl_RS15950	COG4660	Part of a membrane complex involved in electron transport
Tchl_RS15955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tchl_RS15970	COG1280	lysine exporter protein (LysE YggA)
Tchl_RS15980	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Tchl_RS15985	COG2169	Transcriptional regulator
Tchl_RS15985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tchl_RS16025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tchl_RS16040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tchl_RS16075	COG0326	Molecular chaperone. Has ATPase activity
Tchl_RS16105	COG1230	cation diffusion facilitator family transporter
Tchl_RS16110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Tchl_RS16115	COG0643	Histidine kinase
Tchl_RS16115	COG2198	Histidine kinase
Tchl_RS16130	COG0840	transmembrane signaling receptor activity
Tchl_RS16145	COG2197	response regulator
Tchl_RS16155	COG0697	spore germination
Tchl_RS16160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Tchl_RS16170	COG2217	Heavy metal translocating P-type atpase
Tchl_RS16185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tchl_RS16190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tchl_RS16205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tchl_RS16230	COG2010	Cytochrome c
Tchl_RS16245	COG3278	Belongs to the heme-copper respiratory oxidase family
Tchl_RS16255	COG2217	Heavy metal translocating P-type atpase
Tchl_RS16275	COG1346	cytolysis
Tchl_RS16300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tchl_RS16325	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Tchl_RS16330	COG1051	belongs to the nudix hydrolase family
Tchl_RS16335	COG0756	dUTP diphosphatase activity
Tchl_RS16340	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tchl_RS16345	COG2003	Belongs to the UPF0758 family
Tchl_RS16350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tchl_RS16355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tchl_RS16360	COG1278	Cold shock
Tchl_RS16365	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Tchl_RS16370	COG0542	response to heat
Tchl_RS16375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Tchl_RS16415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tchl_RS16420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tchl_RS16425	COG0739	heme binding
Tchl_RS16430	COG0316	Belongs to the HesB IscA family
Tchl_RS16435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tchl_RS16440	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tchl_RS16445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tchl_RS16450	COG1765	OsmC-like protein
Tchl_RS16455	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Tchl_RS16470	COG0247	lactate metabolic process
Tchl_RS16475	COG1592	Rubrerythrin
Tchl_RS16480	COG0494	nUDIX hydrolase
Tchl_RS16485	COG0442	prolyl-tRNA aminoacylation
Tchl_RS16490	COG0741	lytic transglycosylase activity
Tchl_RS16505	COG2204	response regulator
Tchl_RS16515	COG0312	modulator of DNA gyrase
Tchl_RS16520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tchl_RS16530	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Tchl_RS16555	COG0482	sulfurtransferase activity
Tchl_RS16600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tchl_RS16615	COG2096	Adenosyltransferase
Tchl_RS16620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tchl_RS16625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Tchl_RS16630	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Tchl_RS16635	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Tchl_RS16640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Tchl_RS16645	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tchl_RS16650	COG3028	Belongs to the UPF0307 family
Tchl_RS16655	COG0312	modulator of DNA gyrase
Tchl_RS16660	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tchl_RS16665	COG0406	alpha-ribazole phosphatase activity
Tchl_RS16670	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Tchl_RS16680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Tchl_RS16685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tchl_RS16690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tchl_RS16695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tchl_RS16695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tchl_RS16700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tchl_RS16710	COG0793	Belongs to the peptidase S41A family
Tchl_RS16720	COG0640	Transcriptional regulator
Tchl_RS16725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tchl_RS16735	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Tchl_RS16745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tchl_RS16750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Tchl_RS16755	COG1040	competence protein
Tchl_RS16760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tchl_RS16765	COG2226	methyltransferase
Tchl_RS16780	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Tchl_RS16795	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Tchl_RS16800	COG0704	Plays a role in the regulation of phosphate uptake
Tchl_RS16805	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Tchl_RS16810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tchl_RS16810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Tchl_RS16820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tchl_RS16825	COG0483	inositol monophosphate 1-phosphatase activity
Tchl_RS16830	COG3954	Phosphoribulokinase
Tchl_RS16840	COG0672	)-iron permease
Tchl_RS16860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tchl_RS16865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tchl_RS16870	COG0126	phosphoglycerate kinase activity
Tchl_RS16905	COG0285	dihydrofolate synthase activity
Tchl_RS16910	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Tchl_RS16915	COG0159	tryptophan synthase activity
Tchl_RS16920	COG0133	tryptophan synthase activity
Tchl_RS16925	COG0135	phosphoribosylanthranilate isomerase activity
Tchl_RS16930	COG0101	tRNA pseudouridine synthase activity
Tchl_RS16950	COG0473	3-isopropylmalate dehydrogenase activity
Tchl_RS16955	COG0066	3-isopropylmalate dehydratase activity
Tchl_RS16965	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tchl_RS16970	COG0501	Belongs to the peptidase M48B family
Tchl_RS16975	COG2814	Major facilitator Superfamily
Tchl_RS16980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tchl_RS16985	COG0440	acetolactate synthase activity
Tchl_RS16990	COG0028	Belongs to the TPP enzyme family
Tchl_RS16995	COG0318	PFAM AMP-dependent synthetase and ligase
Tchl_RS17015	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tchl_RS17020	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tchl_RS17060	COG0277	FAD linked oxidase domain protein
Tchl_RS17065	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tchl_RS17070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tchl_RS17085	COG1028	Short-chain dehydrogenase reductase Sdr
Tchl_RS17090	COG3243	poly(R)-hydroxyalkanoic acid synthase
Tchl_RS17105	COG0564	pseudouridine synthase activity
Tchl_RS17115	COG2814	Major facilitator Superfamily
Tchl_RS17120	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Tchl_RS17125	COG3383	formate dehydrogenase (NAD+) activity
Tchl_RS17135	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tchl_RS17160	COG4177	L-phenylalanine transmembrane transporter activity
Tchl_RS17165	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tchl_RS17175	COG1024	Enoyl-CoA hydratase
Tchl_RS17185	COG1960	acyl-CoA dehydrogenase activity
Tchl_RS17190	COG0427	acetyl-CoA hydrolase
Tchl_RS17205	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tchl_RS17210	COG1960	acyl-CoA dehydrogenase activity
Tchl_RS17235	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tchl_RS17240	COG1024	Enoyl-CoA hydratase
Tchl_RS17245	COG0183	Belongs to the thiolase family
Tchl_RS17310	COG1309	transcriptional regulator
Tchl_RS17335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tchl_RS17355	COG0288	reversible hydration of carbon dioxide
Tchl_RS17370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tchl_RS17375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tchl_RS17380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tchl_RS17390	COG0569	domain protein
Tchl_RS17395	COG2204	response regulator
Tchl_RS17400	COG5000	phosphorelay sensor kinase activity
Tchl_RS17425	COG2259	Doxx family
Tchl_RS17490	COG0582	viral genome integration into host DNA
Tchl_RS17495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tchl_RS17500	COG0706	membrane insertase activity
Tchl_RS17505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tchl_RS17510	COG0594	ribonuclease P activity
Tchl_RS17515	COG0230	Belongs to the bacterial ribosomal protein bL34 family