locus-tag	class	description
AC731_RS00020	COG2205	protein histidine kinase activity
AC731_RS00040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AC731_RS00045	COG0542	response to heat
AC731_RS00050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AC731_RS00055	COG1278	Cold shock
AC731_RS00060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AC731_RS00065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AC731_RS00070	COG2003	Belongs to the UPF0758 family
AC731_RS00075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AC731_RS00080	COG0756	dUTP diphosphatase activity
AC731_RS00095	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC731_RS00105	COG0640	Transcriptional regulator
AC731_RS00115	COG4654	Cytochrome c, class I
AC731_RS00150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC731_RS00165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AC731_RS00190	COG0697	spore germination
AC731_RS00230	COG3278	Belongs to the heme-copper respiratory oxidase family
AC731_RS00245	COG2010	Cytochrome c
AC731_RS00270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AC731_RS00275	COG3243	poly(R)-hydroxyalkanoic acid synthase
AC731_RS00290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC731_RS00295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AC731_RS00310	COG2217	Heavy metal translocating P-type atpase
AC731_RS00320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AC731_RS00325	COG2201	protein-glutamate methylesterase activity
AC731_RS00335	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AC731_RS00340	COG0840	transmembrane signaling receptor activity
AC731_RS00345	COG0835	chemotaxis
AC731_RS00350	COG0840	transmembrane signaling receptor activity
AC731_RS00355	COG2198	Histidine kinase
AC731_RS00355	COG0643	Histidine kinase
AC731_RS00370	COG0745	RESPONSE REGULATOR receiver
AC731_RS00375	COG0402	S-adenosylhomocysteine deaminase activity
AC731_RS00400	COG2204	response regulator
AC731_RS00415	COG1079	Belongs to the binding-protein-dependent transport system permease family
AC731_RS00420	COG4603	Belongs to the binding-protein-dependent transport system permease family
AC731_RS00425	COG3845	ABC transporter
AC731_RS00430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AC731_RS00460	COG1230	cation diffusion facilitator family transporter
AC731_RS00520	COG0840	transmembrane signaling receptor activity
AC731_RS00525	COG0326	Molecular chaperone. Has ATPase activity
AC731_RS00570	COG0564	pseudouridine synthase activity
AC731_RS00585	COG3243	poly(R)-hydroxyalkanoic acid synthase
AC731_RS00590	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS00605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC731_RS00610	COG1752	Esterase of the alpha-beta hydrolase superfamily
AC731_RS00615	COG0277	FAD linked oxidase domain protein
AC731_RS00650	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC731_RS00655	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AC731_RS00665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AC731_RS00675	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_RS00680	COG0028	Belongs to the TPP enzyme family
AC731_RS00685	COG0440	acetolactate synthase activity
AC731_RS00690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AC731_RS00695	COG2814	Major facilitator Superfamily
AC731_RS00700	COG0501	Belongs to the peptidase M48B family
AC731_RS00705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AC731_RS00715	COG0066	3-isopropylmalate dehydratase activity
AC731_RS00720	COG0473	3-isopropylmalate dehydrogenase activity
AC731_RS00740	COG0101	tRNA pseudouridine synthase activity
AC731_RS00745	COG0135	phosphoribosylanthranilate isomerase activity
AC731_RS00750	COG0133	tryptophan synthase activity
AC731_RS00755	COG0159	tryptophan synthase activity
AC731_RS00760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AC731_RS00765	COG0285	dihydrofolate synthase activity
AC731_RS00790	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC731_RS00795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC731_RS00800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AC731_RS00805	COG0215	cysteine-tRNA ligase activity
AC731_RS00810	COG0484	heat shock protein binding
AC731_RS00815	COG0443	Heat shock 70 kDa protein
AC731_RS00820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AC731_RS00835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AC731_RS00845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC731_RS00850	COG0287	Prephenate dehydrogenase
AC731_RS00855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AC731_RS00865	COG0776	regulation of translation
AC731_RS00875	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AC731_RS00905	COG2261	transglycosylase associated protein
AC731_RS00915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AC731_RS00920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AC731_RS00925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AC731_RS00930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AC731_RS00935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AC731_RS00940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC731_RS00940	COG0072	phenylalanine-tRNA ligase activity
AC731_RS00945	COG0776	regulation of translation
AC731_RS00960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AC731_RS00965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC731_RS00985	COG2951	lytic endotransglycosylase activity
AC731_RS01000	COG0714	Associated with various cellular activities
AC731_RS01005	COG0123	including yeast histone deacetylase and acetoin utilization protein
AC731_RS01010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AC731_RS01015	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AC731_RS01025	COG2850	peptidyl-arginine hydroxylation
AC731_RS01030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC731_RS01050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC731_RS01055	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AC731_RS01075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AC731_RS01080	COG1360	Flagellar Motor Protein
AC731_RS01110	COG1815	bacterial-type flagellum-dependent cell motility
AC731_RS01115	COG1558	bacterial-type flagellum-dependent cell motility
AC731_RS01120	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AC731_RS01125	COG1749	Flagellar hook protein flgE
AC731_RS01130	COG4787	bacterial-type flagellum-dependent cell motility
AC731_RS01140	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AC731_RS01145	COG1706	bacterial-type flagellum-dependent cell motility
AC731_RS01150	COG1705	Flagellar rod assembly protein muramidase FlgJ
AC731_RS01150	COG3951	Flagellar rod assembly protein muramidase FlgJ
AC731_RS01190	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AC731_RS01195	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AC731_RS01215	COG1157	protein secretion by the type III secretion system
AC731_RS01230	COG1766	The M ring may be actively involved in energy transduction
AC731_RS01245	COG1677	Flagellar hook-basal body complex protein FliE
AC731_RS01260	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AC731_RS01265	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AC731_RS01310	COG3754	Rhamnan synthesis protein F
AC731_RS01315	COG1216	Glycosyl transferase, family 2
AC731_RS01325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AC731_RS01360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC731_RS01365	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC731_RS01370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AC731_RS01385	COG4566	intracellular signal transduction
AC731_RS01395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AC731_RS01400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AC731_RS01405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AC731_RS01410	COG0009	L-threonylcarbamoyladenylate synthase
AC731_RS01435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC731_RS01485	COG0732	type I restriction modification DNA specificity domain
AC731_RS01490	COG1401	restriction endodeoxyribonuclease activity
AC731_RS01530	COG2176	DNA-directed DNA polymerase activity
AC731_RS01545	COG0625	glutathione transferase activity
AC731_RS01555	COG1022	Amp-dependent synthetase and ligase
AC731_RS01565	COG0300	oxidoreductase activity
AC731_RS01580	COG0642	Histidine kinase
AC731_RS01595	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC731_RS01600	COG0723	plastoquinol--plastocyanin reductase activity
AC731_RS01615	COG0625	glutathione transferase activity
AC731_RS01620	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AC731_RS01625	COG3383	formate dehydrogenase (NAD+) activity
AC731_RS01630	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
AC731_RS01635	COG3259	Nickel-dependent hydrogenase
AC731_RS01670	COG0473	3-isopropylmalate dehydrogenase activity
AC731_RS01700	COG0583	DNA-binding transcription factor activity
AC731_RS01720	COG0210	DNA helicase
AC731_RS01740	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AC731_RS01815	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AC731_RS01820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC731_RS01850	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AC731_RS01865	COG0395	ABC-type sugar transport system, permease component
AC731_RS01870	COG1175	transmembrane transport
AC731_RS01875	COG1653	transport
AC731_RS01880	COG3842	ATPase activity
AC731_RS01890	COG0438	transferase activity, transferring glycosyl groups
AC731_RS01900	COG2032	superoxide dismutase activity
AC731_RS01910	COG0584	glycerophosphoryl diester phosphodiesterase
AC731_RS01925	COG2951	lytic endotransglycosylase activity
AC731_RS01930	COG2186	Transcriptional regulator
AC731_RS01935	COG1620	l-lactate permease
AC731_RS01940	COG0247	lactate metabolic process
AC731_RS01960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AC731_RS01970	COG0402	S-adenosylhomocysteine deaminase activity
AC731_RS01975	COG2815	serine threonine protein kinase
AC731_RS01975	COG0515	serine threonine protein kinase
AC731_RS01980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AC731_RS01985	COG1420	regulation of RNA biosynthetic process
AC731_RS01990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AC731_RS01995	COG0497	DNA recombination
AC731_RS02000	COG0735	belongs to the Fur family
AC731_RS02005	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC731_RS02010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AC731_RS02020	COG0505	Belongs to the CarA family
AC731_RS02025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AC731_RS02030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC731_RS02035	COG1534	Rna-binding protein
AC731_RS02040	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AC731_RS02045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AC731_RS02050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AC731_RS02055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AC731_RS02060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AC731_RS02065	COG0573	inorganic phosphate transmembrane transporter activity
AC731_RS02070	COG0581	inorganic phosphate transmembrane transporter activity
AC731_RS02075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AC731_RS02080	COG0149	triose-phosphate isomerase activity
AC731_RS02095	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC731_RS02100	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC731_RS02105	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC731_RS02110	COG0649	NAD binding
AC731_RS02115	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AC731_RS02125	COG1034	ATP synthesis coupled electron transport
AC731_RS02130	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AC731_RS02135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AC731_RS02145	COG0713	ATP synthesis coupled electron transport
AC731_RS02160	COG1007	ATP synthesis coupled electron transport
AC731_RS02180	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AC731_RS02180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC731_RS02190	COG2840	Smr protein MutS2
AC731_RS02195	COG0492	ferredoxin-NADP+ reductase activity
AC731_RS02205	COG1674	ftsk spoiiie
AC731_RS02210	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AC731_RS02215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AC731_RS02225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AC731_RS02230	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AC731_RS02235	COG0484	heat shock protein binding
AC731_RS02255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AC731_RS02260	COG1469	GTP cyclohydrolase I activity
AC731_RS02265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AC731_RS02270	COG0142	geranyltranstransferase activity
AC731_RS02275	COG1722	exodeoxyribonuclease VII activity
AC731_RS02285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AC731_RS02290	COG1047	Peptidyl-prolyl cis-trans
AC731_RS02295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AC731_RS02300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AC731_RS02305	COG0196	riboflavin kinase activity
AC731_RS02310	COG0860	N-Acetylmuramoyl-L-alanine amidase
AC731_RS02315	COG0802	atpase or kinase
AC731_RS02350	COG3045	CreA protein
AC731_RS02360	COG2239	Acts as a magnesium transporter
AC731_RS02370	COG0826	peptidase U32
AC731_RS02380	COG2133	pyrroloquinoline quinone binding
AC731_RS02385	COG2815	serine threonine protein kinase
AC731_RS02385	COG0515	serine threonine protein kinase
AC731_RS02395	COG3108	Peptidase M15
AC731_RS02400	COG2989	Protein conserved in bacteria
AC731_RS02405	COG0438	transferase activity, transferring glycosyl groups
AC731_RS02435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AC731_RS02445	COG0640	Transcriptional regulator
AC731_RS02455	COG0798	PFAM Bile acid sodium symporter
AC731_RS02530	COG0019	diaminopimelate decarboxylase activity
AC731_RS02540	COG0840	transmembrane signaling receptor activity
AC731_RS02545	COG1116	anion transmembrane transporter activity
AC731_RS02550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC731_RS02555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC731_RS02560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC731_RS02570	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC731_RS02595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC731_RS02595	COG1116	anion transmembrane transporter activity
AC731_RS02620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC731_RS02625	COG0431	NADPH-dependent FMN reductase
AC731_RS02635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC731_RS02640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AC731_RS02645	COG2011	ABC-type metal ion transport system permease component
AC731_RS02650	COG1464	Belongs to the NlpA lipoprotein family
AC731_RS02655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AC731_RS02665	COG0243	molybdopterin cofactor binding
AC731_RS02680	COG1960	acyl-CoA dehydrogenase activity
AC731_RS02710	COG3829	transcription factor binding
AC731_RS02755	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AC731_RS02795	COG2081	HI0933 family
AC731_RS02825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AC731_RS02830	COG0719	Fe-S assembly protein
AC731_RS02835	COG0396	ATPase activity
AC731_RS02840	COG0719	Fe-S assembly protein
AC731_RS02860	COG2363	Small membrane protein
AC731_RS02865	COG0534	Mate efflux family protein
AC731_RS02870	COG1490	D-aminoacyl-tRNA deacylase activity
AC731_RS02880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AC731_RS02910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC731_RS02930	COG3706	GGDEF domain
AC731_RS02935	COG1902	pentaerythritol trinitrate reductase activity
AC731_RS02940	COG1979	alcohol dehydrogenase
AC731_RS02945	COG1309	transcriptional regulator
AC731_RS02950	COG2814	Major facilitator Superfamily
AC731_RS02955	COG0842	Transport permease protein
AC731_RS02960	COG1129	ABC transporter
AC731_RS02960	COG0842	Transport permease protein
AC731_RS02965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC731_RS02970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC731_RS02975	COG1127	ABC transporter
AC731_RS02990	COG0587	DNA-directed DNA polymerase activity
AC731_RS03000	COG4120	Belongs to the binding-protein-dependent transport system permease family
AC731_RS03005	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AC731_RS03010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC731_RS03020	COG2197	response regulator
AC731_RS03030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC731_RS03030	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AC731_RS03035	COG2354	Protein conserved in bacteria
AC731_RS03040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AC731_RS03055	COG1196	nuclear chromosome segregation
AC731_RS03070	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AC731_RS03100	COG1278	Cold shock
AC731_RS03105	COG1032	radical SAM domain protein
AC731_RS03120	COG1136	(ABC) transporter
AC731_RS03160	COG0501	Belongs to the peptidase M48B family
AC731_RS03165	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AC731_RS03175	COG0254	rRNA binding
AC731_RS03185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AC731_RS03190	COG3318	Belongs to the UPF0149 family
AC731_RS03190	COG3012	SEC-C Motif Domain Protein
AC731_RS03195	COG0727	PFAM Uncharacterised protein family (UPF0153)
AC731_RS03220	COG3012	SEC-C Motif Domain Protein
AC731_RS03230	COG5002	protein histidine kinase activity
AC731_RS03230	COG3447	MASE1 domain protein
AC731_RS03230	COG5001	Diguanylate cyclase
AC731_RS03240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC731_RS03250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AC731_RS03255	COG4215	(ABC) transporter
AC731_RS03260	COG4160	amino acid transport
AC731_RS03270	COG2814	Major facilitator Superfamily
AC731_RS03275	COG0583	DNA-binding transcription factor activity
AC731_RS03285	COG0039	L-malate dehydrogenase activity
AC731_RS03305	COG1053	succinate dehydrogenase
AC731_RS03310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AC731_RS03315	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AC731_RS03320	COG0372	Belongs to the citrate synthase family
AC731_RS03325	COG0567	Dehydrogenase, E1 component
AC731_RS03330	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC731_RS03335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AC731_RS03340	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AC731_RS03405	COG1199	ATP-dependent helicase activity
AC731_RS03415	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AC731_RS03420	COG0415	Belongs to the DNA photolyase family
AC731_RS03425	COG0415	Belongs to the DNA photolyase family
AC731_RS03505	COG1222	aaa ATPase
AC731_RS03555	COG4974	Belongs to the 'phage' integrase family
AC731_RS03655	COG0517	IMP dehydrogenase activity
AC731_RS03660	COG4974	Belongs to the 'phage' integrase family
AC731_RS03680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AC731_RS03695	COG1763	Mo-molybdopterin cofactor biosynthetic process
AC731_RS03700	COG0303	'Molybdopterin
AC731_RS03705	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AC731_RS03710	COG0314	molybdopterin synthase activity
AC731_RS03725	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AC731_RS03730	COG1704	LemA family
AC731_RS03755	COG0657	acetylesterase activity
AC731_RS03765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AC731_RS03770	COG0590	tRNA wobble adenosine to inosine editing
AC731_RS03775	COG1376	ErfK ybiS ycfS ynhG family protein
AC731_RS03780	COG2153	protein acetylation
AC731_RS03785	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AC731_RS03800	COG0354	folic acid binding
AC731_RS03805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AC731_RS03810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC731_RS03825	COG0084	hydrolase, TatD family'
AC731_RS03835	COG0513	Belongs to the DEAD box helicase family
AC731_RS03840	COG2824	Alkylphosphonate utilization operon protein PhnA
AC731_RS03855	COG0728	peptidoglycan biosynthetic process
AC731_RS03860	COG0268	Binds directly to 16S ribosomal RNA
AC731_RS03870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC731_RS03875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AC731_RS03880	COG0137	argininosuccinate synthase activity
AC731_RS03890	COG3123	guanosine phosphorylase activity
AC731_RS03895	COG1666	GTP binding
AC731_RS03955	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC731_RS03960	COG0183	Belongs to the thiolase family
AC731_RS03965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC731_RS03975	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AC731_RS03990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC731_RS04000	COG5002	protein histidine kinase activity
AC731_RS04005	COG0745	RESPONSE REGULATOR receiver
AC731_RS04010	COG2176	DNA-directed DNA polymerase activity
AC731_RS04010	COG5002	protein histidine kinase activity
AC731_RS04015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC731_RS04020	COG3300	MHYT domain
AC731_RS04020	COG5001	Diguanylate cyclase
AC731_RS04025	COG3852	Histidine kinase
AC731_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS04035	COG0542	response to heat
AC731_RS04045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC731_RS04060	COG0601	transmembrane transport
AC731_RS04065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AC731_RS04070	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AC731_RS04075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AC731_RS04085	COG2914	Belongs to the UPF0125 (RnfH) family
AC731_RS04100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AC731_RS04100	COG0519	Catalyzes the synthesis of GMP from XMP
AC731_RS04125	COG4680	protein conserved in bacteria
AC731_RS04135	COG2194	sulfuric ester hydrolase activity
AC731_RS04140	COG0058	SHG alpha-glucan phosphorylase activity
AC731_RS04145	COG0297	glycogen (starch) synthase activity
AC731_RS04150	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AC731_RS04155	COG0033	Phosphoglucomutase
AC731_RS04160	COG1523	belongs to the glycosyl hydrolase 13 family
AC731_RS04170	COG0166	Belongs to the GPI family
AC731_RS04175	COG0837	glucose binding
AC731_RS04180	COG1640	4-alpha-glucanotransferase
AC731_RS04210	COG1959	2 iron, 2 sulfur cluster binding
AC731_RS04215	COG1309	transcriptional regulator
AC731_RS04230	COG0577	efflux transmembrane transporter activity
AC731_RS04230	COG1136	(ABC) transporter
AC731_RS04235	COG1944	ATP diphosphatase activity
AC731_RS04240	COG2186	Transcriptional regulator
AC731_RS04245	COG0277	FAD linked oxidase domain protein
AC731_RS04250	COG0277	FAD linked oxidase domain protein
AC731_RS04255	COG0247	lactate metabolic process
AC731_RS04260	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AC731_RS04265	COG1620	l-lactate permease
AC731_RS04290	COG0435	Glutathione S-transferase
AC731_RS04295	COG0583	DNA-binding transcription factor activity
AC731_RS04300	COG3384	dioxygenase
AC731_RS04305	COG0400	carboxylic ester hydrolase activity
AC731_RS04380	COG0582	viral genome integration into host DNA
AC731_RS04385	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AC731_RS04395	COG0850	regulation of cytokinetic process
AC731_RS04400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AC731_RS04405	COG1393	Belongs to the ArsC family
AC731_RS04410	COG2183	response to ionizing radiation
AC731_RS04420	COG0045	succinate-CoA ligase (ADP-forming) activity
AC731_RS04420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AC731_RS04420	COG1042	CoA-binding domain protein
AC731_RS04425	COG2205	protein histidine kinase activity
AC731_RS04425	COG2202	Pas domain
AC731_RS04435	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AC731_RS04450	COG4181	ATPase activity
AC731_RS04455	COG0560	Phosphoserine phosphatase
AC731_RS04460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AC731_RS04465	COG0598	Magnesium transport protein CorA
AC731_RS04470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AC731_RS04495	COG2078	PFAM AMMECR1 domain protein
AC731_RS04500	COG1355	regulation of microtubule-based process
AC731_RS04505	COG3174	membrane
AC731_RS04510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AC731_RS04515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AC731_RS04530	COG0655	NAD(P)H dehydrogenase (quinone) activity
AC731_RS04535	COG3228	Belongs to the MtfA family
AC731_RS04540	COG0697	spore germination
AC731_RS04545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC731_RS04550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AC731_RS04555	COG0248	Ppx GppA phosphatase
AC731_RS04560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC731_RS04565	COG1127	ABC transporter
AC731_RS04585	COG0084	hydrolase, TatD family'
AC731_RS04590	COG1309	transcriptional regulator
AC731_RS04610	COG1960	acyl-CoA dehydrogenase activity
AC731_RS04615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC731_RS04625	COG2350	Protein conserved in bacteria
AC731_RS04630	COG2917	probably involved in intracellular septation
AC731_RS04640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC731_RS04665	COG1573	uracil-dna glycosylase
AC731_RS04670	COG0477	Major facilitator Superfamily
AC731_RS04675	COG0583	DNA-binding transcription factor activity
AC731_RS04685	COG4772	TonB-dependent receptor
AC731_RS04700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AC731_RS04705	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AC731_RS04715	COG0535	radical SAM domain protein
AC731_RS04720	COG2197	response regulator
AC731_RS04750	COG1131	(ABC) transporter
AC731_RS04840	COG0702	epimerase
AC731_RS04845	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
AC731_RS04850	COG0189	ligase activity
AC731_RS04855	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
AC731_RS04910	COG1229	Formylmethanofuran dehydrogenase subunit A
AC731_RS04915	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
AC731_RS04945	COG3284	Transcriptional regulator
AC731_RS04955	COG0242	peptide deformylase activity
AC731_RS04970	COG0662	Cupin 2, conserved barrel domain protein
AC731_RS04970	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AC731_RS04975	COG1091	dTDP-4-dehydrorhamnose reductase activity
AC731_RS05000	COG1562	ergosterol biosynthetic process
AC731_RS05010	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AC731_RS05015	COG2866	Carboxypeptidase
AC731_RS05020	COG3022	response to hydroperoxide
AC731_RS05030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC731_RS05035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AC731_RS05040	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC731_RS05045	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC731_RS05050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AC731_RS05055	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AC731_RS05075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AC731_RS05080	COG0575	Belongs to the CDS family
AC731_RS05085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AC731_RS05090	COG0233	cytoplasmic translational termination
AC731_RS05095	COG0528	UMP kinase activity
AC731_RS05100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AC731_RS05105	COG0052	Belongs to the universal ribosomal protein uS2 family
AC731_RS05110	COG0024	Methionine aminopeptidase
AC731_RS05115	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AC731_RS05120	COG2862	Uncharacterized protein family, UPF0114
AC731_RS05140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AC731_RS05150	COG1196	nuclear chromosome segregation
AC731_RS05155	COG0436	Aminotransferase
AC731_RS05160	COG2171	N-acyltransferase activity
AC731_RS05170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AC731_RS05180	COG2201	protein-glutamate methylesterase activity
AC731_RS05190	COG0633	Ferredoxin
AC731_RS05195	COG0443	Heat shock 70 kDa protein
AC731_RS05200	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AC731_RS05210	COG0822	iron-sulfur transferase activity
AC731_RS05215	COG1104	cysteine desulfurase activity
AC731_RS05220	COG1104	cysteine desulfurase activity
AC731_RS05230	COG1045	serine acetyltransferase
AC731_RS05240	COG0483	inositol monophosphate 1-phosphatase activity
AC731_RS05420	COG1783	phage Terminase large subunit
AC731_RS05470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AC731_RS05505	COG3723	Recombinational DNA repair protein, rece pathway
AC731_RS05515	COG2974	May be involved in recombination
AC731_RS05520	COG0419	ATPase involved in DNA repair
AC731_RS05565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AC731_RS05580	COG0517	IMP dehydrogenase activity
AC731_RS05590	COG0328	RNA-DNA hybrid ribonuclease activity
AC731_RS05600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC731_RS05605	COG2197	response regulator
AC731_RS05610	COG0741	lytic transglycosylase activity
AC731_RS05610	COG1388	LysM domain
AC731_RS05620	COG1047	Peptidyl-prolyl cis-trans
AC731_RS05635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC731_RS05655	COG0534	Mate efflux family protein
AC731_RS05660	COG1393	Belongs to the ArsC family
AC731_RS05675	COG4628	conserved protein (DUF2132)
AC731_RS05680	COG3040	lipid binding
AC731_RS05685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AC731_RS05700	COG3005	denitrification pathway
AC731_RS05715	COG5001	Diguanylate cyclase
AC731_RS05715	COG4251	negative regulation of phosphorylation
AC731_RS05715	COG2203	Gaf domain
AC731_RS05715	COG3706	GGDEF domain
AC731_RS05735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC731_RS05740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC731_RS05770	COG0589	response to stress
AC731_RS05770	COG0475	glutathione-regulated potassium exporter activity
AC731_RS05810	COG3135	benzoate transporter
AC731_RS05830	COG3384	dioxygenase
AC731_RS05840	COG0861	Integral membrane protein TerC family
AC731_RS05845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AC731_RS05855	COG1858	cytochrome C peroxidase
AC731_RS05870	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AC731_RS05880	COG5002	protein histidine kinase activity
AC731_RS05885	COG2194	sulfuric ester hydrolase activity
AC731_RS05940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AC731_RS05945	COG0671	phosphoesterase, PA-phosphatase related
AC731_RS05960	COG2204	response regulator
AC731_RS05970	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AC731_RS06045	COG0582	viral genome integration into host DNA
AC731_RS06060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AC731_RS06065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AC731_RS06070	COG0740	serine-type endopeptidase activity
AC731_RS06075	COG0544	peptidyl-prolyl cis-trans isomerase activity
AC731_RS06080	COG2766	serine protein kinase
AC731_RS06085	COG2718	Belongs to the UPF0229 family
AC731_RS06090	COG2719	SpoVR family
AC731_RS06095	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AC731_RS06095	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AC731_RS06105	COG0697	spore germination
AC731_RS06130	COG3360	Dodecin
AC731_RS06135	COG2258	MOSC domain
AC731_RS06145	COG0436	Aminotransferase
AC731_RS06155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AC731_RS06160	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AC731_RS06175	COG0791	NLP P60 protein
AC731_RS06185	COG1840	ABC-type Fe3 transport system, periplasmic component
AC731_RS06195	COG1178	ABC-type Fe3 transport system permease component
AC731_RS06200	COG3842	ATPase activity
AC731_RS06205	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AC731_RS06210	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AC731_RS06215	COG0167	dihydroorotate dehydrogenase activity
AC731_RS06230	COG2010	Cytochrome c
AC731_RS06240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AC731_RS06245	COG3706	GGDEF domain
AC731_RS06290	COG2200	EAL domain
AC731_RS06305	COG0535	radical SAM domain protein
AC731_RS06330	COG3391	amine dehydrogenase activity
AC731_RS06340	COG3794	PFAM blue (type 1) copper domain protein
AC731_RS06355	COG2010	Cytochrome c
AC731_RS06525	COG1783	phage Terminase large subunit
AC731_RS06575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AC731_RS06610	COG3723	Recombinational DNA repair protein, rece pathway
AC731_RS06625	COG2974	May be involved in recombination
AC731_RS06630	COG0419	ATPase involved in DNA repair
AC731_RS06695	COG0322	excinuclease ABC activity
AC731_RS06700	COG1472	Belongs to the glycosyl hydrolase 3 family
AC731_RS06705	COG0736	holo-[acyl-carrier-protein] synthase activity
AC731_RS06710	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AC731_RS06715	COG1381	Involved in DNA repair and RecF pathway recombination
AC731_RS06720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AC731_RS06725	COG0571	ribonuclease III activity
AC731_RS06735	COG0681	Belongs to the peptidase S26 family
AC731_RS06740	COG0481	GTPase activity
AC731_RS06750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC731_RS06775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AC731_RS06785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AC731_RS06790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC731_RS06800	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AC731_RS06805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AC731_RS06810	COG0416	fatty acid biosynthetic process
AC731_RS06815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AC731_RS06825	COG0424	maF-like protein
AC731_RS06830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AC731_RS06840	COG0564	pseudouridine synthase activity
AC731_RS06845	COG1530	ribonuclease E activity
AC731_RS06850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AC731_RS06855	COG0556	nucleotide-excision repair
AC731_RS06880	COG0784	Response regulator, receiver
AC731_RS06880	COG2205	protein histidine kinase activity
AC731_RS06880	COG2198	Histidine kinase
AC731_RS06895	COG3647	Membrane
AC731_RS06905	COG1067	ATP-dependent peptidase activity
AC731_RS06910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AC731_RS06935	COG0438	transferase activity, transferring glycosyl groups
AC731_RS06955	COG0776	regulation of translation
AC731_RS07000	COG3409	Peptidoglycan-binding domain 1 protein
AC731_RS07000	COG3267	Type II secretory pathway component ExeA
AC731_RS07100	COG4373	Mu-like prophage FluMu protein gp28
AC731_RS07220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC731_RS07245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AC731_RS07250	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AC731_RS07255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_RS07270	COG0583	DNA-binding transcription factor activity
AC731_RS07285	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AC731_RS07290	COG1473	amidohydrolase
AC731_RS07295	COG0583	DNA-binding transcription factor activity
AC731_RS07305	COG0386	Belongs to the glutathione peroxidase family
AC731_RS07310	COG0488	(ABC) transporter
AC731_RS07325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AC731_RS07330	COG1185	polyribonucleotide nucleotidyltransferase activity
AC731_RS07335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AC731_RS07340	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AC731_RS07345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AC731_RS07350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AC731_RS07355	COG0195	Participates in both transcription termination and antitermination
AC731_RS07355	COG2251	uridine kinase activity
AC731_RS07360	COG0779	Required for maturation of 30S ribosomal subunits
AC731_RS07365	COG1187	pseudouridine synthase activity
AC731_RS07370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AC731_RS07375	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AC731_RS07380	COG1994	Peptidase M50
AC731_RS07385	COG0009	L-threonylcarbamoyladenylate synthase
AC731_RS07390	COG0613	PHP domain protein
AC731_RS07395	COG2267	carboxylic ester hydrolase activity
AC731_RS07405	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AC731_RS07410	COG1278	Cold shock
AC731_RS07435	COG4681	YaeQ
AC731_RS07450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AC731_RS07460	COG0302	gtp cyclohydrolase
AC731_RS07470	COG0306	phosphate transporter
AC731_RS07480	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AC731_RS07505	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AC731_RS07510	COG0148	phosphopyruvate hydratase activity
AC731_RS07515	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AC731_RS07520	COG0504	CTP synthase activity
AC731_RS07530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC731_RS07535	COG0824	Thioesterase
AC731_RS07565	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AC731_RS07570	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AC731_RS07570	COG0047	phosphoribosylformylglycinamidine synthase activity
AC731_RS07580	COG1484	DNA-dependent DNA replication
AC731_RS07585	COG4584	PFAM Integrase catalytic
AC731_RS07620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AC731_RS07625	COG0509	glycine decarboxylation via glycine cleavage system
AC731_RS07630	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC731_RS07630	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AC731_RS07640	COG1215	transferase activity, transferring glycosyl groups
AC731_RS07645	COG0471	metal ion transport
AC731_RS07655	COG0563	adenylate kinase activity
AC731_RS07660	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AC731_RS07665	COG2835	tetraacyldisaccharide 4'-kinase activity
AC731_RS07670	COG1663	tetraacyldisaccharide 4'-kinase activity
AC731_RS07675	COG0848	biopolymer transport protein
AC731_RS07680	COG0811	peptide transport
AC731_RS07685	COG1570	exodeoxyribonuclease VII activity
AC731_RS07690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AC731_RS07695	COG0564	pseudouridine synthase activity
AC731_RS07700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AC731_RS07705	COG2198	Histidine kinase
AC731_RS07705	COG0784	Response regulator, receiver
AC731_RS07705	COG0643	Histidine kinase
AC731_RS07710	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AC731_RS07715	COG0745	RESPONSE REGULATOR receiver
AC731_RS07720	COG0784	Response regulator, receiver
AC731_RS07720	COG0835	chemotaxis
AC731_RS07725	COG0835	chemotaxis
AC731_RS07725	COG0784	Response regulator, receiver
AC731_RS07730	COG1360	Flagellar Motor Protein
AC731_RS07735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AC731_RS07765	COG2878	Part of a membrane complex involved in electron transport
AC731_RS07770	COG4656	Part of a membrane complex involved in electron transport
AC731_RS07780	COG4659	FMN binding
AC731_RS07790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AC731_RS07825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AC731_RS07835	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC731_RS07840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC731_RS07860	COG5002	protein histidine kinase activity
AC731_RS07870	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AC731_RS07875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AC731_RS07890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AC731_RS07905	COG2814	Major facilitator Superfamily
AC731_RS07925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AC731_RS07930	COG3383	formate dehydrogenase (NAD+) activity
AC731_RS07945	COG0583	DNA-binding transcription factor activity
AC731_RS07960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_RS07965	COG1363	Peptidase, m42
AC731_RS07970	COG0189	ligase activity
AC731_RS07970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AC731_RS07985	COG2226	methyltransferase
AC731_RS07990	COG2205	protein histidine kinase activity
AC731_RS07990	COG2198	Histidine kinase
AC731_RS07990	COG0784	Response regulator, receiver
AC731_RS07995	COG0784	Response regulator, receiver
AC731_RS07995	COG5002	protein histidine kinase activity
AC731_RS08010	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AC731_RS08025	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS08035	COG0840	transmembrane signaling receptor activity
AC731_RS08050	COG2086	electron transfer activity
AC731_RS08060	COG1902	pentaerythritol trinitrate reductase activity
AC731_RS08075	COG1960	acyl-CoA dehydrogenase activity
AC731_RS08090	COG2207	Transcriptional regulator
AC731_RS08095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC731_RS08110	COG1309	transcriptional regulator
AC731_RS08115	COG0183	Belongs to the thiolase family
AC731_RS08120	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC731_RS08120	COG1024	Enoyl-CoA hydratase
AC731_RS08130	COG1960	acyl-CoA dehydrogenase activity
AC731_RS08135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC731_RS08140	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_RS08150	COG0786	glutamate:sodium symporter activity
AC731_RS08155	COG0010	Belongs to the arginase family
AC731_RS08175	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_RS08180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC731_RS08195	COG1012	belongs to the aldehyde dehydrogenase family
AC731_RS08205	COG0778	Nitroreductase
AC731_RS08210	COG1024	Enoyl-CoA hydratase
AC731_RS08225	COG1309	transcriptional regulator
AC731_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS08235	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_RS08245	COG0641	radical SAM
AC731_RS08250	COG3119	arylsulfatase activity
AC731_RS08255	COG0714	Associated with various cellular activities
AC731_RS08275	COG2304	oxidoreductase activity
AC731_RS08300	COG1960	acyl-CoA dehydrogenase activity
AC731_RS08305	COG1960	acyl-CoA dehydrogenase activity
AC731_RS08310	COG0183	Belongs to the thiolase family
AC731_RS08320	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS08360	COG4266	Belongs to the allantoicase family
AC731_RS08370	COG0235	Class ii aldolase
AC731_RS08375	COG1942	4-Oxalocrotonate Tautomerase
AC731_RS08380	COG2233	PERMEase
AC731_RS08390	COG4566	intracellular signal transduction
AC731_RS08400	COG0697	spore germination
AC731_RS08405	COG0583	DNA-binding transcription factor activity
AC731_RS08415	COG3960	tartronate-semialdehyde synthase activity
AC731_RS08420	COG3622	Belongs to the hyi family
AC731_RS08425	COG2084	Dehydrogenase
AC731_RS08440	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AC731_RS08445	COG0469	pyruvate kinase activity
AC731_RS08455	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS08460	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS08470	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS08475	COG0183	Belongs to the thiolase family
AC731_RS08480	COG1960	acyl-CoA dehydrogenase activity
AC731_RS08485	COG1960	acyl-CoA dehydrogenase activity
AC731_RS08500	COG1024	Enoyl-CoA hydratase
AC731_RS08540	COG0657	acetylesterase activity
AC731_RS08570	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_RS08585	COG2814	Major facilitator Superfamily
AC731_RS08595	COG0446	pyridine nucleotide-disulphide oxidoreductase
AC731_RS08595	COG1902	pentaerythritol trinitrate reductase activity
AC731_RS08620	COG1595	DNA-templated transcription, initiation
AC731_RS08625	COG0431	NADPH-dependent FMN reductase
AC731_RS08650	COG0778	Nitroreductase
AC731_RS08650	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AC731_RS08655	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AC731_RS08660	COG1920	GTP binding
AC731_RS08665	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AC731_RS08670	COG0175	sulfate reduction
AC731_RS08700	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS08705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AC731_RS08715	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS08740	COG1960	acyl-CoA dehydrogenase activity
AC731_RS08745	COG1960	acyl-CoA dehydrogenase activity
AC731_RS08750	COG1960	acyl-CoA dehydrogenase activity
AC731_RS08765	COG1960	acyl-CoA dehydrogenase activity
AC731_RS08775	COG2814	Major facilitator Superfamily
AC731_RS08795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC731_RS08810	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS08820	COG0300	oxidoreductase activity
AC731_RS08880	COG1012	belongs to the aldehyde dehydrogenase family
AC731_RS08885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC731_RS08900	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AC731_RS08905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC731_RS08955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC731_RS08990	COG4974	Belongs to the 'phage' integrase family
AC731_RS09015	COG3293	Transposase
AC731_RS09025	COG3344	reverse transcriptase
AC731_RS09030	COG2801	Transposase and inactivated derivatives
AC731_RS09075	COG0720	synthase
AC731_RS09080	COG2860	membrane
AC731_RS09085	COG1473	amidohydrolase
AC731_RS09105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC731_RS09110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AC731_RS09110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC731_RS09120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AC731_RS09130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AC731_RS09135	COG1238	metal cluster binding
AC731_RS09150	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AC731_RS09160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC731_RS09165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC731_RS09210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AC731_RS09215	COG0628	permease
AC731_RS09220	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AC731_RS09230	COG0617	tRNA 3'-terminal CCA addition
AC731_RS09245	COG1428	Deoxynucleoside kinase
AC731_RS09250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AC731_RS09255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AC731_RS09260	COG0516	GMP reductase activity
AC731_RS09260	COG0517	IMP dehydrogenase activity
AC731_RS09265	COG0308	aminopeptidase N
AC731_RS09275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AC731_RS09275	COG4651	solute:proton antiporter activity
AC731_RS09290	COG0028	Belongs to the TPP enzyme family
AC731_RS09295	COG0440	acetolactate synthase activity
AC731_RS09300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AC731_RS09305	COG1183	phosphatidylcholine synthase activity
AC731_RS09310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC731_RS09325	COG1295	ribonuclease BN
AC731_RS09335	COG0228	four-way junction DNA binding
AC731_RS09340	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AC731_RS09345	COG0336	Belongs to the RNA methyltransferase TrmD family
AC731_RS09350	COG0335	large ribosomal subunit rRNA binding
AC731_RS09360	COG0795	lipopolysaccharide-transporting ATPase activity
AC731_RS09365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AC731_RS09380	COG0525	valine-tRNA ligase activity
AC731_RS09385	COG0425	Belongs to the sulfur carrier protein TusA family
AC731_RS09390	COG4783	chaperone-mediated protein folding
AC731_RS09395	COG0315	cyclic pyranopterin monophosphate synthase activity
AC731_RS09545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AC731_RS09570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AC731_RS09575	COG2414	aldehyde ferredoxin oxidoreductase
AC731_RS09585	COG3284	Transcriptional regulator
AC731_RS09595	COG1012	belongs to the aldehyde dehydrogenase family
AC731_RS09645	COG0156	8-amino-7-oxononanoate synthase activity
AC731_RS09650	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AC731_RS09655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AC731_RS09660	COG2124	cytochrome p450
AC731_RS09665	COG0443	Heat shock 70 kDa protein
AC731_RS09705	COG0583	DNA-binding transcription factor activity
AC731_RS09715	COG0628	permease
AC731_RS09730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AC731_RS09740	COG1879	ABC-type sugar transport system periplasmic component
AC731_RS09745	COG2205	protein histidine kinase activity
AC731_RS09745	COG0784	Response regulator, receiver
AC731_RS09745	COG2198	Histidine kinase
AC731_RS09760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AC731_RS09765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AC731_RS09770	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AC731_RS09780	COG0521	Mo-molybdopterin cofactor biosynthetic process
AC731_RS09785	COG3028	Belongs to the UPF0307 family
AC731_RS09790	COG0312	modulator of DNA gyrase
AC731_RS09795	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AC731_RS09800	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AC731_RS09810	COG0406	alpha-ribazole phosphatase activity
AC731_RS09815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AC731_RS09830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AC731_RS09835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AC731_RS09840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC731_RS09840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AC731_RS09845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AC731_RS09855	COG0793	Belongs to the peptidase S41A family
AC731_RS09865	COG0640	Transcriptional regulator
AC731_RS09870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC731_RS09880	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AC731_RS09890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AC731_RS09895	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AC731_RS09905	COG2226	methyltransferase
AC731_RS09925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AC731_RS09935	COG1333	cytochrome c biogenesis protein
AC731_RS09940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AC731_RS09945	COG2833	Protein of unknown function (DUF455)
AC731_RS09955	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AC731_RS09960	COG0704	Plays a role in the regulation of phosphate uptake
AC731_RS09965	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AC731_RS09975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AC731_RS09975	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AC731_RS09985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AC731_RS09990	COG0483	inositol monophosphate 1-phosphatase activity
AC731_RS09995	COG3954	Phosphoribulokinase
AC731_RS10000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AC731_RS10005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AC731_RS10010	COG0126	phosphoglycerate kinase activity
AC731_RS10045	COG0583	DNA-binding transcription factor activity
AC731_RS10065	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AC731_RS10070	COG3954	Phosphoribulokinase
AC731_RS10080	COG0126	phosphoglycerate kinase activity
AC731_RS10085	COG0191	fructose-bisphosphate aldolase activity
AC731_RS10095	COG3485	protocatechuate 3,4-dioxygenase
AC731_RS10105	COG2818	Glycosylase
AC731_RS10110	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AC731_RS10130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AC731_RS10140	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AC731_RS10145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AC731_RS10150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AC731_RS10155	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AC731_RS10165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AC731_RS10170	COG0006	proline dipeptidase activity
AC731_RS10175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC731_RS10185	COG2011	ABC-type metal ion transport system permease component
AC731_RS10200	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AC731_RS10205	COG0138	bifunctional purine biosynthesis protein purh
AC731_RS10210	COG0151	Belongs to the GarS family
AC731_RS10215	COG3422	double-strand break repair
AC731_RS10220	COG0408	coproporphyrinogen oxidase activity
AC731_RS10230	COG2959	enzyme of heme biosynthesis
AC731_RS10240	COG0181	hydroxymethylbilane synthase activity
AC731_RS10250	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AC731_RS10260	COG3275	phosphorelay sensor kinase activity
AC731_RS10265	COG0165	Argininosuccinate lyase
AC731_RS10270	COG0515	serine threonine protein kinase
AC731_RS10270	COG2815	serine threonine protein kinase
AC731_RS10275	COG3001	Fructosamine kinase
AC731_RS10300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AC731_RS10305	COG2890	protein-(glutamine-N5) methyltransferase activity
AC731_RS10310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AC731_RS10315	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AC731_RS10360	COG0642	Histidine kinase
AC731_RS10365	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC731_RS10370	COG3162	membrane
AC731_RS10375	COG0642	Histidine kinase
AC731_RS10385	COG0459	protein refolding
AC731_RS10390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AC731_RS10410	COG3273	potassium ion transport
AC731_RS10410	COG0471	metal ion transport
AC731_RS10415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC731_RS10425	COG0604	alcohol dehydrogenase
AC731_RS10435	COG1704	LemA family
AC731_RS10445	COG0488	(ABC) transporter
AC731_RS10480	COG2204	response regulator
AC731_RS10485	COG3852	Histidine kinase
AC731_RS10490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AC731_RS10495	COG2030	dehydratase
AC731_RS10530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AC731_RS10545	COG0717	Belongs to the dCTP deaminase family
AC731_RS10550	COG0489	protein tyrosine kinase activity
AC731_RS10560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC731_RS10560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AC731_RS10565	COG0659	secondary active sulfate transmembrane transporter activity
AC731_RS10570	COG1254	Belongs to the acylphosphatase family
AC731_RS10575	COG0668	transmembrane transport
AC731_RS10590	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
AC731_RS10600	COG1192	Involved in chromosome partitioning
AC731_RS10605	COG0210	DNA helicase
AC731_RS10615	COG0495	leucyl-tRNA aminoacylation
AC731_RS10625	COG1466	dna polymerase III delta subunit
AC731_RS10630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AC731_RS10650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AC731_RS10665	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AC731_RS10670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AC731_RS10690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AC731_RS10745	COG4964	Belongs to the GSP D family
AC731_RS10780	COG3209	COG3209 Rhs family protein
AC731_RS10810	COG0604	alcohol dehydrogenase
AC731_RS10815	COG2070	2-Nitropropane dioxygenase
AC731_RS10840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AC731_RS10860	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AC731_RS10875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AC731_RS10895	COG0071	Belongs to the small heat shock protein (HSP20) family
AC731_RS10900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AC731_RS10925	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AC731_RS10930	COG3338	carbonate dehydratase activity
AC731_RS10935	COG0351	phosphomethylpyrimidine kinase
AC731_RS10940	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AC731_RS10945	COG1063	alcohol dehydrogenase
AC731_RS10955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AC731_RS10960	COG0668	transmembrane transport
AC731_RS10965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC731_RS10975	COG1715	Restriction endonuclease
AC731_RS10980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC731_RS10985	COG1136	(ABC) transporter
AC731_RS10985	COG0577	efflux transmembrane transporter activity
AC731_RS10990	COG0577	efflux transmembrane transporter activity
AC731_RS10990	COG1136	(ABC) transporter
AC731_RS10995	COG0577	efflux transmembrane transporter activity
AC731_RS10995	COG1136	(ABC) transporter
AC731_RS11005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC731_RS11005	COG2111	Na H antiporter
AC731_RS11010	COG1006	Multisubunit Na H antiporter MnhC subunit
AC731_RS11015	COG0651	ATP synthesis coupled electron transport
AC731_RS11020	COG1863	multisubunit Na H antiporter MnhE subunit
AC731_RS11025	COG2212	antiporter activity
AC731_RS11030	COG1320	monovalent cation:proton antiporter activity
AC731_RS11035	COG1187	pseudouridine synthase activity
AC731_RS11040	COG1320	monovalent cation:proton antiporter activity
AC731_RS11045	COG2212	antiporter activity
AC731_RS11050	COG1863	multisubunit Na H antiporter MnhE subunit
AC731_RS11055	COG0651	ATP synthesis coupled electron transport
AC731_RS11060	COG1006	Multisubunit Na H antiporter MnhC subunit
AC731_RS11065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC731_RS11065	COG2111	Na H antiporter
AC731_RS11070	COG1414	Transcriptional regulator
AC731_RS11085	COG0281	malic enzyme
AC731_RS11085	COG0280	phosphate acetyltransferase
AC731_RS11090	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AC731_RS11095	COG0436	Aminotransferase
AC731_RS11100	COG0741	lytic transglycosylase activity
AC731_RS11115	COG0175	sulfate reduction
AC731_RS11120	COG1218	3'(2'),5'-bisphosphate nucleotidase
AC731_RS11125	COG3273	potassium ion transport
AC731_RS11125	COG0471	metal ion transport
AC731_RS11130	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_RS11170	COG1696	Membrane protein involved in D-alanine export
AC731_RS11185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC731_RS11225	COG1216	Glycosyl transferase, family 2
AC731_RS11230	COG1216	Glycosyl transferase, family 2
AC731_RS11255	COG0438	transferase activity, transferring glycosyl groups
AC731_RS11275	COG0367	asparagine synthase
AC731_RS11280	COG0438	transferase activity, transferring glycosyl groups
AC731_RS11310	COG3267	Type II secretory pathway component ExeA
AC731_RS11310	COG3409	Peptidoglycan-binding domain 1 protein
AC731_RS11320	COG0489	protein tyrosine kinase activity
AC731_RS11335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AC731_RS11355	COG0436	Aminotransferase
AC731_RS11360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AC731_RS11365	COG0235	Class ii aldolase
AC731_RS11365	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AC731_RS11370	COG2084	Dehydrogenase
AC731_RS11375	COG2084	Dehydrogenase
AC731_RS11380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AC731_RS11395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AC731_RS11405	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AC731_RS11435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AC731_RS11445	COG0629	single-stranded DNA binding
AC731_RS11450	COG2814	Major facilitator Superfamily
AC731_RS11460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AC731_RS11465	COG0203	ribosomal protein L17
AC731_RS11470	COG0202	RNA polymerase activity
AC731_RS11475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AC731_RS11480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AC731_RS11485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AC731_RS11490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AC731_RS11495	COG0201	protein transport
AC731_RS11500	COG0200	Binds to the 23S rRNA
AC731_RS11505	COG1841	ribosomal large subunit assembly
AC731_RS11510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AC731_RS11515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AC731_RS11520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AC731_RS11525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AC731_RS11530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AC731_RS11535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AC731_RS11540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AC731_RS11545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AC731_RS11550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AC731_RS11555	COG0255	Belongs to the universal ribosomal protein uL29 family
AC731_RS11560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AC731_RS11565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AC731_RS11570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AC731_RS11575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AC731_RS11580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AC731_RS11585	COG0089	rRNA binding
AC731_RS11590	COG0088	Forms part of the polypeptide exit tunnel
AC731_RS11595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AC731_RS11600	COG0051	transcription antitermination factor activity, RNA binding
AC731_RS11605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC731_RS11610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AC731_RS11615	COG0049	tRNA binding
AC731_RS11620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AC731_RS11625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AC731_RS11630	COG0085	RNA polymerase activity
AC731_RS11635	COG0222	ribosome binding
AC731_RS11640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AC731_RS11645	COG0081	regulation of translation
AC731_RS11650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AC731_RS11660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AC731_RS11670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AC731_RS11705	COG2197	response regulator
AC731_RS11715	COG2205	protein histidine kinase activity
AC731_RS11715	COG2198	Histidine kinase
AC731_RS11715	COG0784	Response regulator, receiver
AC731_RS11725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC731_RS11760	COG1022	Amp-dependent synthetase and ligase
AC731_RS11780	COG0840	transmembrane signaling receptor activity
AC731_RS11785	COG1703	isobutyryl-CoA mutase activity
AC731_RS11785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AC731_RS11785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AC731_RS11810	COG2321	neutral zinc metallopeptidase
AC731_RS11815	COG1509	lysine 2,3-aminomutase activity
AC731_RS11820	COG2111	Na H antiporter
AC731_RS11820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AC731_RS11825	COG1006	Multisubunit Na H antiporter MnhC subunit
AC731_RS11830	COG0651	ATP synthesis coupled electron transport
AC731_RS11835	COG1863	multisubunit Na H antiporter MnhE subunit
AC731_RS11840	COG2212	antiporter activity
AC731_RS11845	COG1320	monovalent cation:proton antiporter activity
AC731_RS11850	COG4770	biotin carboxylase activity
AC731_RS11855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC731_RS11860	COG1703	isobutyryl-CoA mutase activity
AC731_RS11865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AC731_RS11865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AC731_RS11870	COG1802	Transcriptional regulator
AC731_RS11875	COG1253	flavin adenine dinucleotide binding
AC731_RS11880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC731_RS11885	COG3162	membrane
AC731_RS11890	COG1024	Enoyl-CoA hydratase
AC731_RS11905	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AC731_RS11910	COG2274	protein secretion by the type I secretion system
AC731_RS11920	COG2197	response regulator
AC731_RS11955	COG1136	(ABC) transporter
AC731_RS11965	COG0735	belongs to the Fur family
AC731_RS11975	COG1121	(ABC) transporter
AC731_RS11980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AC731_RS11985	COG0803	Belongs to the bacterial solute-binding protein 9 family
AC731_RS12000	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AC731_RS12010	COG0129	dihydroxy-acid dehydratase activity
AC731_RS12015	COG3132	Protein of unknown function, DUF480
AC731_RS12020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AC731_RS12030	COG5001	Diguanylate cyclase
AC731_RS12075	COG1858	cytochrome C peroxidase
AC731_RS12080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC731_RS12085	COG0577	efflux transmembrane transporter activity
AC731_RS12085	COG1136	(ABC) transporter
AC731_RS12095	COG4774	siderophore transport
AC731_RS12110	COG3128	pkhd-type hydroxylase
AC731_RS12120	COG1116	anion transmembrane transporter activity
AC731_RS12135	COG4206	TonB-dependent receptor
AC731_RS12145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AC731_RS12165	COG0745	RESPONSE REGULATOR receiver
AC731_RS12170	COG0784	Response regulator, receiver
AC731_RS12170	COG4191	Histidine kinase
AC731_RS12175	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_RS12180	COG0659	secondary active sulfate transmembrane transporter activity
AC731_RS12195	COG2119	membrane
AC731_RS12200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC731_RS12220	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AC731_RS12245	COG4178	(ABC) transporter
AC731_RS12260	COG1132	(ABC) transporter
AC731_RS12265	COG3634	alkyl hydroperoxide reductase activity
AC731_RS12275	COG2177	Part of the ABC transporter FtsEX involved in
AC731_RS12280	COG2884	Cell division ATP-binding protein ftsE
AC731_RS12290	COG0612	Peptidase, M16
AC731_RS12295	COG0612	Peptidase, M16
AC731_RS12300	COG0742	ribosomal rna small subunit methyltransferase
AC731_RS12305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AC731_RS12310	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AC731_RS12315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AC731_RS12320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AC731_RS12330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AC731_RS12335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AC731_RS12345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC731_RS12350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AC731_RS12355	COG0193	aminoacyl-tRNA hydrolase activity
AC731_RS12365	COG0012	GTP binding
AC731_RS12370	COG3344	reverse transcriptase
AC731_RS12395	COG4263	nitrous-oxide reductase activity
AC731_RS12445	COG3245	cytochrome
AC731_RS12450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AC731_RS12455	COG1832	CoA-binding protein
AC731_RS12460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AC731_RS12465	COG3568	Endonuclease Exonuclease Phosphatase
AC731_RS12470	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AC731_RS12480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AC731_RS12485	COG0174	glutamine synthetase
AC731_RS12495	COG3852	Histidine kinase
AC731_RS12505	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AC731_RS12505	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AC731_RS12510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AC731_RS12515	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AC731_RS12525	COG0237	dephospho-CoA kinase activity
AC731_RS12530	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AC731_RS12535	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AC731_RS12540	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AC731_RS12540	COG0352	thiamine-phosphate diphosphorylase activity
AC731_RS12555	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AC731_RS12565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AC731_RS12595	COG0305	Participates in initiation and elongation during chromosome replication
AC731_RS12600	COG0359	binds to the 23S rRNA
AC731_RS12605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AC731_RS12610	COG2965	DNA replication, synthesis of RNA primer
AC731_RS12615	COG0360	Binds together with S18 to 16S ribosomal RNA
AC731_RS12625	COG1643	Atp-dependent helicase
AC731_RS12640	COG1968	undecaprenyl-diphosphatase activity
AC731_RS12645	COG3150	esterase
AC731_RS12650	COG2226	methyltransferase
AC731_RS12660	COG0557	exoribonuclease II activity
AC731_RS12670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC731_RS12675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AC731_RS12680	COG2239	Acts as a magnesium transporter
AC731_RS12685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AC731_RS12690	COG0352	thiamine-phosphate diphosphorylase activity
AC731_RS12695	COG0351	phosphomethylpyrimidine kinase
AC731_RS12715	COG0835	chemotaxis
AC731_RS12720	COG0840	transmembrane signaling receptor activity
AC731_RS12730	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AC731_RS12735	COG0415	Belongs to the DNA photolyase family
AC731_RS12740	COG1678	Uncharacterized ACR, COG1678
AC731_RS12745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AC731_RS12750	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AC731_RS12755	COG0540	Belongs to the ATCase OTCase family
AC731_RS12760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AC731_RS12765	COG0762	integral membrane protein
AC731_RS12805	COG0437	4 iron, 4 sulfur cluster binding
AC731_RS12810	COG0243	molybdopterin cofactor binding
AC731_RS12810	COG3383	formate dehydrogenase (NAD+) activity
AC731_RS12845	COG0746	molybdenum cofactor guanylyltransferase activity
AC731_RS12860	COG2026	Addiction module toxin, RelE StbE family
AC731_RS12880	COG4969	Belongs to the N-Me-Phe pilin family
AC731_RS12905	COG1131	(ABC) transporter
AC731_RS12910	COG4636	protein conserved in cyanobacteria
AC731_RS12915	COG1763	Mo-molybdopterin cofactor biosynthetic process
AC731_RS12920	COG3852	Histidine kinase
AC731_RS12930	COG1981	membrane
AC731_RS12945	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AC731_RS12950	COG5002	protein histidine kinase activity
AC731_RS12960	COG4654	Cytochrome c, class I
AC731_RS12965	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC731_RS12965	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AC731_RS12970	COG1492	cobalamin metabolic process
AC731_RS12975	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AC731_RS12985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AC731_RS13000	COG0513	Belongs to the DEAD box helicase family
AC731_RS13005	COG0427	acetyl-CoA hydrolase
AC731_RS13020	COG0688	phosphatidylethanolamine metabolic process
AC731_RS13035	COG1797	cobyrinic acid a,c-diamide synthase activity
AC731_RS13040	COG1648	precorrin-2 dehydrogenase activity
AC731_RS13040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AC731_RS13055	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AC731_RS13060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AC731_RS13065	COG4206	TonB-dependent receptor
AC731_RS13075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AC731_RS13080	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AC731_RS13085	COG0406	alpha-ribazole phosphatase activity
AC731_RS13090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AC731_RS13090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AC731_RS13115	COG0438	transferase activity, transferring glycosyl groups
AC731_RS13120	COG0438	transferase activity, transferring glycosyl groups
AC731_RS13130	COG0859	PFAM glycosyl transferase family 9
AC731_RS13140	COG0438	transferase activity, transferring glycosyl groups
AC731_RS13145	COG0726	polysaccharide deacetylase
AC731_RS13150	COG1132	(ABC) transporter
AC731_RS13160	COG1682	transport, permease protein
AC731_RS13165	COG1134	teichoic acid transport
AC731_RS13195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AC731_RS13220	COG3668	Plasmid stabilization system
AC731_RS13235	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AC731_RS13235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AC731_RS13260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AC731_RS13275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AC731_RS13280	COG0799	negative regulation of ribosome biogenesis
AC731_RS13285	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AC731_RS13290	COG0424	maF-like protein
AC731_RS13320	COG1294	oxidase, subunit
AC731_RS13360	COG0632	four-way junction helicase activity
AC731_RS13365	COG2255	four-way junction helicase activity
AC731_RS13380	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AC731_RS13390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AC731_RS13395	COG1560	Kdo2-lipid A biosynthetic process
AC731_RS13405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AC731_RS13420	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AC731_RS13425	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AC731_RS13430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AC731_RS13440	COG0433	COG0433 Predicted ATPase
AC731_RS13450	COG0217	transcriptional regulatory protein
AC731_RS13460	COG0393	Putative heavy-metal-binding
AC731_RS13465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AC731_RS13510	COG2308	Evidence 4 Homologs of previously reported genes of
AC731_RS13540	COG2945	thiolester hydrolase activity
AC731_RS13540	COG0596	Alpha beta hydrolase
AC731_RS13545	COG0625	glutathione transferase activity
AC731_RS13550	COG1324	tolerance protein
AC731_RS13555	COG4232	protein-disulfide reductase activity
AC731_RS13570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AC731_RS13575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC731_RS13590	COG0375	protein maturation
AC731_RS13600	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AC731_RS13605	COG0298	carbon dioxide binding
AC731_RS13610	COG0409	Hydrogenase expression formation protein
AC731_RS13615	COG0309	Hydrogenase expression formation protein (HypE)
AC731_RS13630	COG0765	amino acid transport
AC731_RS13635	COG1126	abc transporter atp-binding protein
AC731_RS13645	COG1335	isochorismatase
AC731_RS13650	COG0513	Belongs to the DEAD box helicase family
AC731_RS13665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AC731_RS13670	COG1194	a g-specific adenine glycosylase
AC731_RS13695	COG0559	Belongs to the binding-protein-dependent transport system permease family
AC731_RS13710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC731_RS13715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AC731_RS13725	COG1652	LysM domain
AC731_RS13745	COG3384	dioxygenase
AC731_RS13750	COG0583	DNA-binding transcription factor activity
AC731_RS13755	COG0826	peptidase U32
AC731_RS13760	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AC731_RS13780	COG0322	excinuclease ABC activity
AC731_RS13785	COG3300	MHYT domain
AC731_RS13785	COG5001	Diguanylate cyclase
AC731_RS13825	COG0693	protein deglycase activity
AC731_RS13830	COG3344	reverse transcriptase
AC731_RS13845	COG0210	DNA helicase
AC731_RS13865	COG2201	protein-glutamate methylesterase activity
AC731_RS13890	COG3284	Transcriptional regulator
AC731_RS13895	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS13905	COG1063	alcohol dehydrogenase
AC731_RS13920	COG1278	Cold shock
AC731_RS13935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AC731_RS13940	COG0321	lipoyl(octanoyl) transferase activity
AC731_RS13945	COG2921	Belongs to the UPF0250 family
AC731_RS13955	COG1686	Belongs to the peptidase S11 family
AC731_RS13965	COG0772	Belongs to the SEDS family
AC731_RS13970	COG0768	penicillin binding
AC731_RS13985	COG1077	Cell shape determining protein MreB Mrl
AC731_RS13990	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AC731_RS13995	COG0154	amidase activity
AC731_RS14005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AC731_RS14010	COG2391	methyltransferase activity
AC731_RS14015	COG0121	glutamine amidotransferase
AC731_RS14035	COG0745	RESPONSE REGULATOR receiver
AC731_RS14045	COG2226	methyltransferase
AC731_RS14060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AC731_RS14065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AC731_RS14070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AC731_RS14075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AC731_RS14080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AC731_RS14085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AC731_RS14095	COG0356	it plays a direct role in the translocation of protons across the membrane
AC731_RS14115	COG1475	DNA binding
AC731_RS14120	COG1192	Involved in chromosome partitioning
AC731_RS14125	COG0357	Ribosomal RNA small subunit methyltransferase G
AC731_RS14130	COG0445	tRNA wobble uridine modification
AC731_RS14135	COG1024	Enoyl-CoA hydratase
AC731_RS14145	COG1024	Enoyl-CoA hydratase
AC731_RS14170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AC731_RS14195	COG1132	(ABC) transporter
AC731_RS14210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AC731_RS14225	COG1253	flavin adenine dinucleotide binding
AC731_RS14230	COG3344	reverse transcriptase
AC731_RS14235	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AC731_RS14255	COG3179	chitinase
AC731_RS14280	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AC731_RS14315	COG0679	Auxin Efflux Carrier
AC731_RS14320	COG2186	Transcriptional regulator
AC731_RS14330	COG2084	Dehydrogenase
AC731_RS14340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AC731_RS14345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_RS14360	COG2706	6-phosphogluconolactonase activity
AC731_RS14365	COG2721	sulfolactate sulfo-lyase activity
AC731_RS14375	COG1929	Belongs to the glycerate kinase type-1 family
AC731_RS14380	COG3835	regulator
AC731_RS14395	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AC731_RS14400	COG0840	transmembrane signaling receptor activity
AC731_RS14420	COG2974	May be involved in recombination
AC731_RS14430	COG1187	pseudouridine synthase activity
AC731_RS14445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AC731_RS14455	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AC731_RS14485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC731_RS14495	COG1858	cytochrome C peroxidase
AC731_RS14510	COG0348	domain, Protein
AC731_RS14520	COG3909	cytochrome
AC731_RS14530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC731_RS14535	COG4206	TonB-dependent receptor
AC731_RS14545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AC731_RS14545	COG0551	DNA topoisomerase type I activity
AC731_RS14550	COG2922	Belongs to the Smg family
AC731_RS14555	COG0758	DNA mediated transformation
AC731_RS14560	COG1652	LysM domain
AC731_RS14565	COG0242	peptide deformylase activity
AC731_RS14570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AC731_RS14575	COG0501	Belongs to the peptidase M48B family
AC731_RS14580	COG1196	nuclear chromosome segregation
AC731_RS14580	COG3264	Mechanosensitive ion channel
AC731_RS14590	COG0583	DNA-binding transcription factor activity
AC731_RS14595	COG0477	Major facilitator Superfamily
AC731_RS14625	COG1451	nucleotide metabolic process
AC731_RS14630	COG3909	cytochrome
AC731_RS14645	COG1192	Involved in chromosome partitioning
AC731_RS14660	COG3781	membrane
AC731_RS14690	COG1802	Transcriptional regulator
AC731_RS14695	COG0730	response to heat
AC731_RS14700	COG0154	amidase activity
AC731_RS14715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AC731_RS14720	COG1116	anion transmembrane transporter activity
AC731_RS14735	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AC731_RS14740	COG0594	ribonuclease P activity
AC731_RS14745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AC731_RS14750	COG0706	membrane insertase activity
AC731_RS14755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AC731_RS14765	COG4106	trans-aconitate 2-methyltransferase activity
AC731_RS14780	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AC731_RS14785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AC731_RS14785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AC731_RS14805	COG0569	domain protein
AC731_RS14815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AC731_RS14820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AC731_RS14830	COG1940	carbohydrate kinase activity
AC731_RS14835	COG0288	reversible hydration of carbon dioxide
AC731_RS14855	COG2223	nitrite transmembrane transporter activity
AC731_RS14865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC731_RS14865	COG2813	Specifically methylates the guanine in position
AC731_RS14870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AC731_RS14880	COG2022	thiamine diphosphate biosynthetic process
AC731_RS14885	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AC731_RS14890	COG0616	signal peptide processing
AC731_RS14895	COG1881	PFAM PEBP family protein
AC731_RS14900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AC731_RS14905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AC731_RS14910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AC731_RS14925	COG1561	YicC-like family, N-terminal region
AC731_RS14930	COG0194	GDP metabolic process
AC731_RS14935	COG1758	RNA polymerase activity
AC731_RS14940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AC731_RS14945	COG3706	GGDEF domain
AC731_RS14955	COG1199	ATP-dependent helicase activity
AC731_RS14955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AC731_RS14965	COG3850	Histidine kinase
AC731_RS14970	COG2197	response regulator
AC731_RS14975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AC731_RS14975	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
AC731_RS14985	COG0243	molybdopterin cofactor binding
AC731_RS14990	COG0437	4 iron, 4 sulfur cluster binding
AC731_RS14995	COG0348	domain, Protein
AC731_RS15000	COG3043	anaerobic respiration
AC731_RS15005	COG3005	denitrification pathway
AC731_RS15010	COG4133	protoheme IX ABC transporter activity
AC731_RS15030	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AC731_RS15040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC731_RS15050	COG4235	cytochrome complex assembly
AC731_RS15055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AC731_RS15060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC731_RS15080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AC731_RS15085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC731_RS15090	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AC731_RS15095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AC731_RS15160	COG1476	TRANSCRIPTIONal
AC731_RS15190	COG1525	nuclease
AC731_RS15205	COG2135	peptidase activity
AC731_RS15210	COG0517	IMP dehydrogenase activity
AC731_RS15215	COG4974	Belongs to the 'phage' integrase family
AC731_RS15275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC731_RS15330	COG5002	protein histidine kinase activity
AC731_RS15340	COG0517	IMP dehydrogenase activity
AC731_RS15345	COG4974	Belongs to the 'phage' integrase family
AC731_RS15350	COG0488	(ABC) transporter
AC731_RS15355	COG3706	GGDEF domain
AC731_RS15365	COG2201	protein-glutamate methylesterase activity
AC731_RS15385	COG0419	ATPase involved in DNA repair
AC731_RS15390	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AC731_RS15395	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AC731_RS15400	COG0583	DNA-binding transcription factor activity
AC731_RS15420	COG2267	carboxylic ester hydrolase activity
AC731_RS15425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_RS15435	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AC731_RS15445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AC731_RS15450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC731_RS15460	COG0523	cobalamin synthesis protein
AC731_RS15470	COG2703	oxygen carrier activity
AC731_RS15480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AC731_RS15505	COG2095	MarC family integral membrane protein
AC731_RS15520	COG5002	protein histidine kinase activity
AC731_RS15520	COG5001	Diguanylate cyclase
AC731_RS15520	COG3447	MASE1 domain protein
AC731_RS15525	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AC731_RS15530	COG1739	Uncharacterized protein family UPF0029
AC731_RS15535	COG0783	Belongs to the Dps family
AC731_RS15540	COG3046	protein related to deoxyribodipyrimidine photolyase
AC731_RS15555	COG1074	ATP-dependent DNA helicase activity
AC731_RS15560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AC731_RS15605	COG2610	gluconate transmembrane transporter activity
AC731_RS15620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AC731_RS15625	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_RS15630	COG0732	type I restriction modification DNA specificity domain
AC731_RS15630	COG0827	DNA restriction-modification system
AC731_RS15635	COG3437	response regulator, receiver
AC731_RS15645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_RS15650	COG5001	Diguanylate cyclase
AC731_RS15705	COG0683	leucine binding
AC731_RS15715	COG1522	sequence-specific DNA binding
AC731_RS15725	COG0189	ligase activity
AC731_RS15740	COG1280	lysine exporter protein (LysE YggA)
AC731_RS15745	COG3135	benzoate transporter
AC731_RS15750	COG0697	spore germination
AC731_RS15760	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AC731_RS15765	COG3383	formate dehydrogenase (NAD+) activity
AC731_RS15780	COG0583	DNA-binding transcription factor activity
AC731_RS15810	COG0154	amidase activity
AC731_RS15835	COG0346	lactoylglutathione lyase activity
AC731_RS15855	COG0488	(ABC) transporter
AC731_RS15870	COG0788	formyltetrahydrofolate deformylase activity
AC731_RS15875	COG0527	aspartate kinase activity
AC731_RS15880	COG0004	ammonium transporteR
AC731_RS15885	COG0347	Belongs to the P(II) protein family
AC731_RS15900	COG0606	chelatase, subunit chli
AC731_RS15955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC731_RS15960	COG0583	DNA-binding transcription factor activity
AC731_RS15980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AC731_RS16000	COG3876	Protein conserved in bacteria
AC731_RS16015	COG0668	transmembrane transport
AC731_RS16025	COG0180	Tryptophanyl-tRNA synthetase
AC731_RS16035	COG1917	Cupin 2, conserved barrel domain protein
AC731_RS16035	COG4977	sequence-specific DNA binding
AC731_RS16040	COG0583	DNA-binding transcription factor activity
AC731_RS16045	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AC731_RS16050	COG4208	sulfate ABC transporter
AC731_RS16065	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AC731_RS16070	COG0583	DNA-binding transcription factor activity
AC731_RS16075	COG3038	cytochrome b561
AC731_RS16085	COG2353	YceI-like domain
AC731_RS16090	COG1741	Belongs to the pirin family
AC731_RS16100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AC731_RS16105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC731_RS16110	COG1414	Transcriptional regulator
AC731_RS16130	COG0730	response to heat
AC731_RS16140	COG1414	Transcriptional regulator
AC731_RS16190	COG2855	membrane
AC731_RS16195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AC731_RS16205	COG2022	thiamine diphosphate biosynthetic process
AC731_RS16210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC731_RS16220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC731_RS16225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_RS16230	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AC731_RS16235	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AC731_RS16235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AC731_RS16250	COG0583	DNA-binding transcription factor activity
AC731_RS16265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AC731_RS16275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AC731_RS16280	COG0277	FAD linked oxidase domain protein
AC731_RS16300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC731_RS16365	COG0490	domain, Protein
AC731_RS16365	COG0471	metal ion transport
AC731_RS16375	COG0829	nickel cation binding
AC731_RS16380	COG0831	urea catabolic process
AC731_RS16385	COG0832	Belongs to the urease beta subunit family
AC731_RS16390	COG0804	urea catabolic process
AC731_RS16395	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AC731_RS16400	COG0830	nickel cation binding
AC731_RS16405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AC731_RS16415	COG0840	transmembrane signaling receptor activity
AC731_RS16415	COG0840	transmembrane signaling receptor activity
AC731_RS16425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AC731_RS16480	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AC731_RS16485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AC731_RS16490	COG2233	PERMEase
AC731_RS16505	COG4575	ribosome binding
AC731_RS16510	COG2226	methyltransferase
AC731_RS16515	COG0708	Exodeoxyribonuclease III
AC731_RS16520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AC731_RS16540	COG0251	oxidation-reduction process
AC731_RS16545	COG1238	metal cluster binding
AC731_RS16560	COG0037	tRNA processing
AC731_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS16585	COG0617	tRNA 3'-terminal CCA addition
AC731_RS16605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AC731_RS16610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AC731_RS16615	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AC731_RS16625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AC731_RS16630	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AC731_RS16635	COG1137	ATPase activity
AC731_RS16640	COG2137	regulation of response to DNA damage stimulus
AC731_RS16645	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AC731_RS16650	COG1546	Belongs to the CinA family
AC731_RS16655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AC731_RS16665	COG3154	lipid carrier protein
AC731_RS16670	COG0826	peptidase U32
AC731_RS16675	COG0826	peptidase U32
AC731_RS16680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AC731_RS16685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AC731_RS16690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AC731_RS16695	COG0018	arginyl-trna synthetase
AC731_RS16705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AC731_RS16725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AC731_RS16740	COG3243	poly(R)-hydroxyalkanoic acid synthase
AC731_RS16760	COG0288	reversible hydration of carbon dioxide
AC731_RS16765	COG0183	Belongs to the thiolase family
AC731_RS16770	COG1960	acyl-CoA dehydrogenase activity
AC731_RS16775	COG2807	transmembrane transport
AC731_RS16790	COG2159	amidohydrolase
AC731_RS16820	COG0667	Aldo Keto reductase
AC731_RS16830	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS16840	COG1053	succinate dehydrogenase
AC731_RS16845	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS16870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AC731_RS16875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AC731_RS16880	COG0583	DNA-binding transcription factor activity
AC731_RS16925	COG0589	response to stress
AC731_RS16930	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC731_RS16935	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AC731_RS16940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AC731_RS16945	COG1414	Transcriptional regulator
AC731_RS16965	COG1414	Transcriptional regulator
AC731_RS16985	COG0673	inositol 2-dehydrogenase activity
AC731_RS16990	COG1028	Short-chain dehydrogenase reductase Sdr
AC731_RS17000	COG1053	succinate dehydrogenase
AC731_RS17005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AC731_RS17035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AC731_RS17040	COG0583	DNA-binding transcription factor activity
AC731_RS17045	COG1760	l-serine dehydratase
AC731_RS17050	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AC731_RS17070	COG1607	acyl-coa hydrolase
AC731_RS17095	COG1960	acyl-CoA dehydrogenase activity
AC731_RS17115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AC731_RS17120	COG1024	Enoyl-CoA hydratase
AC731_RS17130	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_RS17145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AC731_RS17150	COG1132	(ABC) transporter
AC731_RS17160	COG0644	oxidoreductase
AC731_RS17195	COG1012	belongs to the aldehyde dehydrogenase family
AC731_RS17205	COG1115	amino acid carrier protein
AC731_RS17210	COG1660	Displays ATPase and GTPase activities
AC731_RS17225	COG0412	Dienelactone hydrolase
AC731_RS17230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AC731_RS17235	COG1671	Belongs to the UPF0178 family
AC731_RS17250	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AC731_RS17255	COG0602	queuosine metabolic process
AC731_RS17270	COG0823	Involved in the tonB-independent uptake of proteins
AC731_RS17280	COG0848	biopolymer transport protein
AC731_RS17290	COG0824	Thioesterase
AC731_RS17300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AC731_RS17305	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AC731_RS17320	COG0330	HflC and HflK could
AC731_RS17345	COG2895	sulfate adenylyltransferase (ATP) activity
AC731_RS17350	COG0175	sulfate reduction
AC731_RS17355	COG0175	sulfate reduction
AC731_RS17370	COG0583	DNA-binding transcription factor activity
AC731_RS17375	COG0252	asparaginase activity
AC731_RS17385	COG5265	(ABC) transporter
AC731_RS17405	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC731_RS17405	COG1024	Enoyl-CoA hydratase
AC731_RS17410	COG1607	acyl-coa hydrolase
AC731_RS17415	COG2067	long-chain fatty acid transport protein
AC731_RS17420	COG1250	3-hydroxyacyl-CoA dehydrogenase
AC731_RS17420	COG1024	Enoyl-CoA hydratase
AC731_RS17425	COG0183	Belongs to the thiolase family
AC731_RS17435	COG1805	sodium ion transport
AC731_RS17480	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AC731_RS17490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AC731_RS17495	COG3161	chorismate lyase activity
AC731_RS17500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AC731_RS17505	COG0284	orotidine-5'-phosphate decarboxylase activity
AC731_RS17510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AC731_RS17530	COG0019	diaminopimelate decarboxylase activity
AC731_RS17535	COG1965	Belongs to the frataxin family
AC731_RS17570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AC731_RS17575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AC731_RS17580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AC731_RS17585	COG0067	glutamate synthase
AC731_RS17585	COG0069	glutamate synthase activity
AC731_RS17585	COG0070	glutamate synthase
AC731_RS17595	COG0747	negative chemotaxis
AC731_RS17600	COG3706	GGDEF domain
AC731_RS17600	COG2203	Gaf domain
AC731_RS17600	COG5001	Diguanylate cyclase
AC731_RS17600	COG4251	negative regulation of phosphorylation
AC731_RS17615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC731_RS17625	COG0405	Gamma-glutamyltransferase
AC731_RS17630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AC731_RS17640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AC731_RS17650	COG0348	domain, Protein
AC731_RS17665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AC731_RS17670	COG4974	Belongs to the 'phage' integrase family
AC731_RS17680	COG5002	protein histidine kinase activity
AC731_RS17705	COG2132	Multicopper oxidase
AC731_RS17730	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AC731_RS17760	COG0840	transmembrane signaling receptor activity
AC731_RS17765	COG0840	transmembrane signaling receptor activity
AC731_RS17785	COG1280	lysine exporter protein (LysE YggA)
AC731_RS17815	COG1172	Belongs to the binding-protein-dependent transport system permease family
AC731_RS17830	COG1022	Amp-dependent synthetase and ligase
AC731_RS17835	COG1024	Enoyl-CoA hydratase
AC731_RS17840	COG1960	acyl-CoA dehydrogenase activity
AC731_RS17855	COG0318	PFAM AMP-dependent synthetase and ligase
AC731_RS17860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AC731_RS17880	COG0628	permease
AC731_RS17890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AC731_RS17895	COG1702	phosphate starvation-inducible protein PhoH
AC731_RS17900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AC731_RS17905	COG4535	Mg2 and Co2 transporter CorC
AC731_RS17910	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AC731_RS17915	COG0752	glycyl-tRNA synthetase alpha subunit
AC731_RS17920	COG0751	glycine-tRNA ligase activity
AC731_RS17925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AC731_RS17930	COG0204	Acyl-transferase
AC731_RS17935	COG2154	pterin-4-alpha-carbinolamine dehydratase
AC731_RS17945	COG1024	Enoyl-CoA hydratase
AC731_RS17950	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AC731_RS18000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC731_RS18010	COG1127	ABC transporter
AC731_RS18015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AC731_RS18020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AC731_RS18040	COG1131	(ABC) transporter
AC731_RS18045	COG0842	Transport permease protein
AC731_RS18055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AC731_RS18060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AC731_RS18065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AC731_RS18070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AC731_RS18075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AC731_RS18080	COG0131	Imidazoleglycerol-phosphate dehydratase
AC731_RS18085	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AC731_RS18090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AC731_RS18095	COG0107	imidazoleglycerol-phosphate synthase activity
AC731_RS18100	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AC731_RS18105	COG0140	phosphoribosyl-ATP diphosphatase activity
AC731_RS18115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC731_RS18120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AC731_RS18125	COG0805	protein transport
AC731_RS18130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AC731_RS18135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AC731_RS18150	COG0045	succinate-CoA ligase (ADP-forming) activity
AC731_RS18155	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AC731_RS18170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AC731_RS18175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AC731_RS18180	COG0546	phosphoglycolate phosphatase activity
AC731_RS18195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AC731_RS18200	COG0134	indole-3-glycerol-phosphate synthase activity
AC731_RS18210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AC731_RS18220	COG1522	sequence-specific DNA binding
AC731_RS18225	COG0733	neurotransmitter:sodium symporter activity
AC731_RS18290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC731_RS18310	COG0300	oxidoreductase activity
AC731_RS18325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AC731_RS18330	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AC731_RS18365	COG0109	protoheme IX farnesyltransferase activity
AC731_RS18370	COG1999	signal sequence binding
AC731_RS18375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AC731_RS18390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AC731_RS18405	COG0537	adenosine 5'-monophosphoramidase activity
AC731_RS18410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AC731_RS18425	COG2264	protein methyltransferase activity
AC731_RS18430	COG0439	Biotin carboxylase
AC731_RS18435	COG0511	ligase activity, forming carbon-carbon bonds
AC731_RS18440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AC731_RS18450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC731_RS18460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AC731_RS18465	COG0792	nuclease activity
AC731_RS18475	COG0418	dihydroorotase activity
AC731_RS18490	COG2001	Belongs to the MraZ family
AC731_RS18495	COG0275	rRNA processing
AC731_RS18500	COG3116	cell division
AC731_RS18510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AC731_RS18515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AC731_RS18520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AC731_RS18525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AC731_RS18530	COG0772	Belongs to the SEDS family
AC731_RS18535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AC731_RS18540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AC731_RS18545	COG1181	Belongs to the D-alanine--D-alanine ligase family
AC731_RS18550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AC731_RS18560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AC731_RS18565	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AC731_RS18580	COG0653	protein targeting
AC731_RS18620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AC731_RS18625	COG2967	ApaG domain
AC731_RS18640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AC731_RS18645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AC731_RS18650	COG1862	Preprotein translocase
AC731_RS18655	COG0343	queuine tRNA-ribosyltransferase activity
AC731_RS18660	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AC731_RS18705	COG0583	DNA-binding transcription factor activity
AC731_RS18715	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AC731_RS18735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AC731_RS18755	COG0583	DNA-binding transcription factor activity
AC731_RS18765	COG0670	Belongs to the BI1 family
AC731_RS18770	COG0825	malonyl-CoA metabolic process
AC731_RS18775	COG0037	tRNA processing
AC731_RS18805	COG0105	UTP biosynthetic process
AC731_RS18810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AC731_RS18825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AC731_RS18830	COG0124	histidyl-tRNA synthetase
AC731_RS18840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AC731_RS18845	COG1160	GTP binding
AC731_RS18850	COG1923	regulation of RNA biosynthetic process
AC731_RS18855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AC731_RS18860	COG0330	HflC and HflK could
AC731_RS18865	COG0330	HflC and HflK could
AC731_RS18875	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AC731_RS18880	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AC731_RS18895	COG0557	exoribonuclease II activity
AC731_RS18900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AC731_RS18905	COG0778	Nitroreductase
AC731_RS18910	COG5001	Diguanylate cyclase
AC731_RS18915	COG0490	domain, Protein
AC731_RS18915	COG0471	metal ion transport
AC731_RS18930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC731_RS18945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AC731_RS18950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AC731_RS18955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AC731_RS18960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AC731_RS18965	COG0723	plastoquinol--plastocyanin reductase activity
AC731_RS18970	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AC731_RS18975	COG2857	Cytochrome c1
AC731_RS18980	COG0625	glutathione transferase activity
AC731_RS18985	COG2969	positive regulation of protein catabolic process
AC731_RS18990	COG2703	oxygen carrier activity
AC731_RS18995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AC731_RS19000	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AC731_RS19010	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AC731_RS19020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AC731_RS19030	COG0022	dehydrogenase e1 component
AC731_RS19030	COG0508	dehydrogenase complex catalyzes the overall conversion of
AC731_RS19040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AC731_RS19050	COG2226	methyltransferase
AC731_RS19085	COG2409	Drug exporters of the RND superfamily
AC731_RS19090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AC731_RS19095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AC731_RS19100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AC731_RS19105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AC731_RS19115	COG0631	protein serine/threonine phosphatase activity
AC731_RS19125	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AC731_RS19145	COG0513	Belongs to the DEAD box helicase family
AC731_RS19150	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AC731_RS19160	COG1653	transport
AC731_RS19165	COG0142	geranyltranstransferase activity
AC731_RS19175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AC731_RS19180	COG2096	Adenosyltransferase
AC731_RS19185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AC731_RS19200	COG0429	hydrolase of the alpha beta-hydrolase fold
AC731_RS19230	COG0482	sulfurtransferase activity
AC731_RS19255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AC731_RS19260	COG3164	Protein of unknown function
AC731_RS19265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AC731_RS19270	COG0312	modulator of DNA gyrase
AC731_RS19285	COG2204	response regulator
AC731_RS19295	COG2205	protein histidine kinase activity
AC731_RS19305	COG0741	lytic transglycosylase activity
AC731_RS19310	COG0442	prolyl-tRNA aminoacylation
AC731_RS19315	COG0494	nUDIX hydrolase
AC731_RS19325	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AC731_RS19330	COG1765	OsmC-like protein
AC731_RS19335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AC731_RS19340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AC731_RS19345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AC731_RS19350	COG0316	Belongs to the HesB IscA family
AC731_RS19355	COG0739	heme binding
AC731_RS19360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AC731_RS19365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis