locus-tag	class	description
DIE29_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DIE29_RS00010	COG0592	DNA-directed DNA polymerase activity
DIE29_RS00035	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DIE29_RS00050	COG2974	May be involved in recombination
DIE29_RS00060	COG1187	pseudouridine synthase activity
DIE29_RS00070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DIE29_RS00080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DIE29_RS00090	COG3909	cytochrome
DIE29_RS00095	COG0840	transmembrane signaling receptor activity
DIE29_RS00100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DIE29_RS00105	COG4772	TonB-dependent receptor
DIE29_RS00110	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DIE29_RS00120	COG0523	cobalamin synthesis protein
DIE29_RS00130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIE29_RS00135	COG2951	lytic endotransglycosylase activity
DIE29_RS00145	COG0625	glutathione transferase activity
DIE29_RS00150	COG2267	carboxylic ester hydrolase activity
DIE29_RS00170	COG1028	Short-chain dehydrogenase reductase Sdr
DIE29_RS00175	COG0037	tRNA processing
DIE29_RS00205	COG4566	intracellular signal transduction
DIE29_RS00230	COG0210	DNA helicase
DIE29_RS00245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DIE29_RS00250	COG0321	lipoyl(octanoyl) transferase activity
DIE29_RS00255	COG2921	Belongs to the UPF0250 family
DIE29_RS00265	COG1686	Belongs to the peptidase S11 family
DIE29_RS00275	COG0772	Belongs to the SEDS family
DIE29_RS00280	COG0768	penicillin binding
DIE29_RS00290	COG1792	Involved in formation and maintenance of cell shape
DIE29_RS00295	COG1077	Cell shape determining protein MreB Mrl
DIE29_RS00300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DIE29_RS00305	COG0154	amidase activity
DIE29_RS00310	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DIE29_RS00315	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DIE29_RS00325	COG0501	Belongs to the peptidase M48B family
DIE29_RS00330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DIE29_RS00335	COG0242	peptide deformylase activity
DIE29_RS00340	COG1652	LysM domain
DIE29_RS00345	COG0758	DNA mediated transformation
DIE29_RS00350	COG2922	Belongs to the Smg family
DIE29_RS00360	COG0783	Belongs to the Dps family
DIE29_RS00370	COG3437	response regulator, receiver
DIE29_RS00370	COG0784	Response regulator, receiver
DIE29_RS00410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DIE29_RS00415	COG0602	queuosine metabolic process
DIE29_RS00425	COG2885	chlorophyll binding
DIE29_RS00430	COG0823	Involved in the tonB-independent uptake of proteins
DIE29_RS00445	COG0811	peptide transport
DIE29_RS00450	COG0824	Thioesterase
DIE29_RS00460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DIE29_RS00465	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DIE29_RS00470	COG0189	ligase activity
DIE29_RS00470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DIE29_RS00475	COG0189	ligase activity
DIE29_RS00475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DIE29_RS00480	COG1132	(ABC) transporter
DIE29_RS00495	COG2895	sulfate adenylyltransferase (ATP) activity
DIE29_RS00500	COG0175	sulfate reduction
DIE29_RS00505	COG0175	sulfate reduction
DIE29_RS00515	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DIE29_RS00520	COG0583	DNA-binding transcription factor activity
DIE29_RS00525	COG0252	asparaginase activity
DIE29_RS00530	COG1027	Aspartate ammonia-lyase
DIE29_RS00535	COG5265	(ABC) transporter
DIE29_RS00555	COG1960	acyl-CoA dehydrogenase activity
DIE29_RS00580	COG2067	long-chain fatty acid transport protein
DIE29_RS00585	COG1250	3-hydroxyacyl-CoA dehydrogenase
DIE29_RS00585	COG1024	Enoyl-CoA hydratase
DIE29_RS00590	COG0183	Belongs to the thiolase family
DIE29_RS00605	COG1805	sodium ion transport
DIE29_RS00620	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DIE29_RS00630	COG1024	Enoyl-CoA hydratase
DIE29_RS00655	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DIE29_RS00665	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DIE29_RS00670	COG3161	chorismate lyase activity
DIE29_RS00675	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DIE29_RS00680	COG0284	orotidine-5'-phosphate decarboxylase activity
DIE29_RS00690	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DIE29_RS00725	COG1965	Belongs to the frataxin family
DIE29_RS00760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DIE29_RS00765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DIE29_RS00770	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DIE29_RS00775	COG0070	glutamate synthase
DIE29_RS00775	COG0069	glutamate synthase activity
DIE29_RS00775	COG0067	glutamate synthase
DIE29_RS00795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DIE29_RS00835	COG0559	Belongs to the binding-protein-dependent transport system permease family
DIE29_RS00840	COG2070	2-Nitropropane dioxygenase
DIE29_RS00845	COG2860	membrane
DIE29_RS00860	COG5001	Diguanylate cyclase
DIE29_RS00875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DIE29_RS00880	COG3132	Protein of unknown function, DUF480
DIE29_RS00885	COG0129	dihydroxy-acid dehydratase activity
DIE29_RS00905	COG1121	(ABC) transporter
DIE29_RS00910	COG0735	belongs to the Fur family
DIE29_RS00920	COG1136	(ABC) transporter
DIE29_RS00935	COG1194	a g-specific adenine glycosylase
DIE29_RS00940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DIE29_RS00955	COG0310	cobalt ion transport
DIE29_RS00960	COG0310	cobalt ion transport
DIE29_RS00970	COG1122	ATPase activity
DIE29_RS00990	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DIE29_RS01010	COG2204	response regulator
DIE29_RS01015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DIE29_RS01015	COG1024	Enoyl-CoA hydratase
DIE29_RS01020	COG0309	Hydrogenase expression formation protein (HypE)
DIE29_RS01025	COG0409	Hydrogenase expression formation protein
DIE29_RS01030	COG0298	carbon dioxide binding
DIE29_RS01035	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DIE29_RS01045	COG0375	protein maturation
DIE29_RS01090	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DIE29_RS01105	COG1902	pentaerythritol trinitrate reductase activity
DIE29_RS01120	COG0583	DNA-binding transcription factor activity
DIE29_RS01125	COG0583	DNA-binding transcription factor activity
DIE29_RS01130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DIE29_RS01135	COG3002	Belongs to the UPF0753 family
DIE29_RS01150	COG3706	GGDEF domain
DIE29_RS01160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DIE29_RS01165	COG0459	protein refolding
DIE29_RS01180	COG1024	Enoyl-CoA hydratase
DIE29_RS01185	COG1250	3-hydroxyacyl-CoA dehydrogenase
DIE29_RS01190	COG2050	protein possibly involved in aromatic compounds catabolism
DIE29_RS01200	COG3396	Phenylacetate-CoA oxygenase
DIE29_RS01205	COG3460	Phenylacetate-CoA oxygenase
DIE29_RS01210	COG3396	Phenylacetate-CoA oxygenase
DIE29_RS01215	COG2151	metal-sulfur cluster biosynthetic enzyme
DIE29_RS01220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DIE29_RS01230	COG0183	Belongs to the thiolase family
DIE29_RS01265	COG0513	Belongs to the DEAD box helicase family
DIE29_RS01270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DIE29_RS01275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DIE29_RS01290	COG4232	protein-disulfide reductase activity
DIE29_RS01300	COG0625	glutathione transferase activity
DIE29_RS01320	COG3154	lipid carrier protein
DIE29_RS01325	COG0826	peptidase U32
DIE29_RS01330	COG0826	peptidase U32
DIE29_RS01340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DIE29_RS01350	COG0018	arginyl-trna synthetase
DIE29_RS01375	COG2358	TRAP transporter, solute receptor (TAXI family
DIE29_RS01380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DIE29_RS01395	COG0303	'Molybdopterin
DIE29_RS01400	COG0437	4 iron, 4 sulfur cluster binding
DIE29_RS01405	COG2414	aldehyde ferredoxin oxidoreductase
DIE29_RS01410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DIE29_RS01430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DIE29_RS01445	COG3243	poly(R)-hydroxyalkanoic acid synthase
DIE29_RS01465	COG1960	acyl-CoA dehydrogenase activity
DIE29_RS01470	COG0183	Belongs to the thiolase family
DIE29_RS01475	COG1960	acyl-CoA dehydrogenase activity
DIE29_RS01485	COG2207	Transcriptional regulator
DIE29_RS01490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DIE29_RS01525	COG1115	amino acid carrier protein
DIE29_RS01530	COG1660	Displays ATPase and GTPase activities
DIE29_RS01545	COG0642	Histidine kinase
DIE29_RS01570	COG1858	cytochrome C peroxidase
DIE29_RS01580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DIE29_RS01585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DIE29_RS01590	COG2201	protein-glutamate methylesterase activity
DIE29_RS01595	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DIE29_RS01605	COG0840	transmembrane signaling receptor activity
DIE29_RS01610	COG0835	chemotaxis
DIE29_RS01615	COG0840	transmembrane signaling receptor activity
DIE29_RS01620	COG0643	Histidine kinase
DIE29_RS01620	COG2198	Histidine kinase
DIE29_RS01635	COG0745	RESPONSE REGULATOR receiver
DIE29_RS01640	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DIE29_RS01645	COG0393	Putative heavy-metal-binding
DIE29_RS01655	COG0217	transcriptional regulatory protein
DIE29_RS01665	COG0433	COG0433 Predicted ATPase
DIE29_RS01675	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DIE29_RS01680	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DIE29_RS01685	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DIE29_RS01695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DIE29_RS01705	COG1560	Kdo2-lipid A biosynthetic process
DIE29_RS01715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DIE29_RS01725	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DIE29_RS01755	COG2255	four-way junction helicase activity
DIE29_RS01765	COG0632	four-way junction helicase activity
DIE29_RS01775	COG1530	ribonuclease E activity
DIE29_RS01780	COG0424	maF-like protein
DIE29_RS01785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DIE29_RS01790	COG0799	negative regulation of ribosome biogenesis
DIE29_RS01795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DIE29_RS01810	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DIE29_RS01835	COG1218	3'(2'),5'-bisphosphate nucleotidase
DIE29_RS01840	COG3273	potassium ion transport
DIE29_RS01840	COG0471	metal ion transport
DIE29_RS01845	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DIE29_RS01860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DIE29_RS01865	COG0109	protoheme IX farnesyltransferase activity
DIE29_RS01870	COG1612	heme a metabolic process
DIE29_RS01900	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DIE29_RS01905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DIE29_RS01920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIE29_RS01930	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DIE29_RS01935	COG1492	cobalamin metabolic process
DIE29_RS01965	COG2358	TRAP transporter, solute receptor (TAXI family
DIE29_RS01970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DIE29_RS01975	COG1960	acyl-CoA dehydrogenase activity
DIE29_RS01985	COG0840	transmembrane signaling receptor activity
DIE29_RS01995	COG1024	Enoyl-CoA hydratase
DIE29_RS02000	COG1253	flavin adenine dinucleotide binding
DIE29_RS02005	COG1802	Transcriptional regulator
DIE29_RS02010	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DIE29_RS02010	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DIE29_RS02015	COG1703	isobutyryl-CoA mutase activity
DIE29_RS02020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DIE29_RS02030	COG4770	biotin carboxylase activity
DIE29_RS02035	COG1509	lysine 2,3-aminomutase activity
DIE29_RS02050	COG0784	Response regulator, receiver
DIE29_RS02050	COG4191	Histidine kinase
DIE29_RS02060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DIE29_RS02060	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DIE29_RS02060	COG1703	isobutyryl-CoA mutase activity
DIE29_RS02070	COG1022	Amp-dependent synthetase and ligase
DIE29_RS02080	COG0559	Belongs to the binding-protein-dependent transport system permease family
DIE29_RS02105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DIE29_RS02115	COG2205	protein histidine kinase activity
DIE29_RS02135	COG0500	methyltransferase
DIE29_RS02145	COG0277	FAD linked oxidase domain protein
DIE29_RS02165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DIE29_RS02175	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DIE29_RS02185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DIE29_RS02190	COG0081	regulation of translation
DIE29_RS02195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DIE29_RS02200	COG0222	ribosome binding
DIE29_RS02205	COG0085	RNA polymerase activity
DIE29_RS02210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DIE29_RS02215	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DIE29_RS02220	COG0049	tRNA binding
DIE29_RS02225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DIE29_RS02230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DIE29_RS02235	COG0051	transcription antitermination factor activity, RNA binding
DIE29_RS02240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DIE29_RS02245	COG0088	Forms part of the polypeptide exit tunnel
DIE29_RS02250	COG0089	rRNA binding
DIE29_RS02255	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DIE29_RS02260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DIE29_RS02265	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DIE29_RS02270	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DIE29_RS02275	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DIE29_RS02280	COG0255	Belongs to the universal ribosomal protein uL29 family
DIE29_RS02285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DIE29_RS02290	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DIE29_RS02295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DIE29_RS02300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DIE29_RS02305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DIE29_RS02310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DIE29_RS02315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DIE29_RS02320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DIE29_RS02325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DIE29_RS02330	COG1841	ribosomal large subunit assembly
DIE29_RS02335	COG0200	Binds to the 23S rRNA
DIE29_RS02340	COG0201	protein transport
DIE29_RS02345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DIE29_RS02350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DIE29_RS02355	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DIE29_RS02360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DIE29_RS02365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DIE29_RS02370	COG0202	RNA polymerase activity
DIE29_RS02375	COG0203	ribosomal protein L17
DIE29_RS02380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DIE29_RS02400	COG2814	Major facilitator Superfamily
DIE29_RS02405	COG0629	single-stranded DNA binding
DIE29_RS02415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DIE29_RS02620	COG2842	Transposition protein
DIE29_RS02650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DIE29_RS02680	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DIE29_RS02680	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DIE29_RS02685	COG4654	Cytochrome c, class I
DIE29_RS02695	COG3852	Histidine kinase
DIE29_RS02700	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DIE29_RS02705	COG0543	2 iron, 2 sulfur cluster binding
DIE29_RS02705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DIE29_RS02715	COG1981	membrane
DIE29_RS02720	COG0746	molybdenum cofactor guanylyltransferase activity
DIE29_RS02750	COG0762	integral membrane protein
DIE29_RS02755	COG1872	DUF167
DIE29_RS02770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DIE29_RS02775	COG0540	Belongs to the ATCase OTCase family
DIE29_RS02780	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DIE29_RS02785	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DIE29_RS02790	COG1678	Uncharacterized ACR, COG1678
DIE29_RS02795	COG0415	Belongs to the DNA photolyase family
DIE29_RS02800	COG0643	Histidine kinase
DIE29_RS02800	COG2198	Histidine kinase
DIE29_RS02805	COG0840	transmembrane signaling receptor activity
DIE29_RS02810	COG0835	chemotaxis
DIE29_RS02825	COG1773	rubredoxin
DIE29_RS02830	COG0352	thiamine-phosphate diphosphorylase activity
DIE29_RS02835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DIE29_RS02840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DIE29_RS02845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DIE29_RS02850	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DIE29_RS02860	COG0494	nUDIX hydrolase
DIE29_RS02865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DIE29_RS02870	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DIE29_RS02875	COG0237	dephospho-CoA kinase activity
DIE29_RS02885	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DIE29_RS02890	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DIE29_RS02905	COG3852	Histidine kinase
DIE29_RS02915	COG0174	glutamine synthetase
DIE29_RS02930	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DIE29_RS02940	COG0662	Cupin 2, conserved barrel domain protein
DIE29_RS02945	COG1850	ribulose-bisphosphate carboxylase activity
DIE29_RS02950	COG3568	Endonuclease Exonuclease Phosphatase
DIE29_RS02955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DIE29_RS02960	COG1832	CoA-binding protein
DIE29_RS02965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DIE29_RS03080	COG0659	secondary active sulfate transmembrane transporter activity
DIE29_RS03085	COG0589	response to stress
DIE29_RS03095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DIE29_RS03115	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DIE29_RS03140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DIE29_RS03205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DIE29_RS03210	COG1205	dead DEAH box helicase
DIE29_RS03210	COG1111	helicase
DIE29_RS03240	COG0582	viral genome integration into host DNA
DIE29_RS03245	COG0012	GTP binding
DIE29_RS03250	COG0193	aminoacyl-tRNA hydrolase activity
DIE29_RS03255	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DIE29_RS03260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DIE29_RS03270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DIE29_RS03275	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DIE29_RS03285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DIE29_RS03290	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DIE29_RS03295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DIE29_RS03300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DIE29_RS03305	COG0742	ribosomal rna small subunit methyltransferase
DIE29_RS03310	COG0612	Peptidase, M16
DIE29_RS03315	COG0612	Peptidase, M16
DIE29_RS03325	COG2884	Cell division ATP-binding protein ftsE
DIE29_RS03330	COG2177	Part of the ABC transporter FtsEX involved in
DIE29_RS03345	COG1132	(ABC) transporter
DIE29_RS03365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DIE29_RS03370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DIE29_RS03375	COG1862	Preprotein translocase
DIE29_RS03390	COG2011	ABC-type metal ion transport system permease component
DIE29_RS03420	COG0683	leucine binding
DIE29_RS03425	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DIE29_RS03425	COG0506	proline dehydrogenase activity
DIE29_RS03425	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DIE29_RS03430	COG1522	sequence-specific DNA binding
DIE29_RS03435	COG0343	queuine tRNA-ribosyltransferase activity
DIE29_RS03440	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DIE29_RS03450	COG0583	DNA-binding transcription factor activity
DIE29_RS03460	COG0670	Belongs to the BI1 family
DIE29_RS03465	COG0825	malonyl-CoA metabolic process
DIE29_RS03470	COG0037	tRNA processing
DIE29_RS03485	COG0105	UTP biosynthetic process
DIE29_RS03490	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DIE29_RS03505	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DIE29_RS03510	COG0124	histidyl-tRNA synthetase
DIE29_RS03520	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DIE29_RS03525	COG1160	GTP binding
DIE29_RS03530	COG1923	regulation of RNA biosynthetic process
DIE29_RS03535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DIE29_RS03540	COG0330	HflC and HflK could
DIE29_RS03545	COG0330	HflC and HflK could
DIE29_RS03555	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DIE29_RS03560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DIE29_RS03575	COG0557	exoribonuclease II activity
DIE29_RS03580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DIE29_RS03585	COG3707	response regulator
DIE29_RS03590	COG1116	anion transmembrane transporter activity
DIE29_RS03590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DIE29_RS03595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DIE29_RS03600	COG1116	anion transmembrane transporter activity
DIE29_RS03610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DIE29_RS03620	COG0243	molybdopterin cofactor binding
DIE29_RS03625	COG0583	DNA-binding transcription factor activity
DIE29_RS03655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DIE29_RS03660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DIE29_RS03665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DIE29_RS03670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DIE29_RS03675	COG0723	plastoquinol--plastocyanin reductase activity
DIE29_RS03680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DIE29_RS03685	COG2857	Cytochrome c1
DIE29_RS03690	COG0625	glutathione transferase activity
DIE29_RS03695	COG2969	positive regulation of protein catabolic process
DIE29_RS03700	COG0438	transferase activity, transferring glycosyl groups
DIE29_RS03705	COG2703	oxygen carrier activity
DIE29_RS03715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DIE29_RS03720	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DIE29_RS03730	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DIE29_RS03735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DIE29_RS03740	COG0459	protein refolding
DIE29_RS03750	COG0642	Histidine kinase
DIE29_RS03760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DIE29_RS03775	COG4555	ABC transporter
DIE29_RS03790	COG0741	lytic transglycosylase activity
DIE29_RS03795	COG0442	prolyl-tRNA aminoacylation
DIE29_RS03800	COG0494	nUDIX hydrolase
DIE29_RS03815	COG0733	neurotransmitter:sodium symporter activity
DIE29_RS03820	COG1522	sequence-specific DNA binding
DIE29_RS03825	COG1116	anion transmembrane transporter activity
DIE29_RS03830	COG0390	transport system, permease component
DIE29_RS03855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DIE29_RS03875	COG2096	Adenosyltransferase
DIE29_RS03880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DIE29_RS03895	COG0429	hydrolase of the alpha beta-hydrolase fold
DIE29_RS03915	COG0668	transmembrane transport
DIE29_RS03930	COG0482	sulfurtransferase activity
DIE29_RS03950	COG3025	triphosphatase activity
DIE29_RS03955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DIE29_RS03960	COG3164	Protein of unknown function
DIE29_RS03965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DIE29_RS03970	COG0312	modulator of DNA gyrase
DIE29_RS04010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DIE29_RS04015	COG0542	response to heat
DIE29_RS04020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DIE29_RS04025	COG1278	Cold shock
DIE29_RS04030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DIE29_RS04035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DIE29_RS04040	COG2003	Belongs to the UPF0758 family
DIE29_RS04045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DIE29_RS04050	COG0756	dUTP diphosphatase activity
DIE29_RS04060	COG0446	pyridine nucleotide-disulphide oxidoreductase
DIE29_RS04080	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DIE29_RS04085	COG0538	isocitrate dehydrogenase activity
DIE29_RS04090	COG0589	response to stress
DIE29_RS04100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DIE29_RS04115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DIE29_RS04130	COG2885	chlorophyll binding
DIE29_RS04135	COG3706	GGDEF domain
DIE29_RS04170	COG0126	phosphoglycerate kinase activity
DIE29_RS04175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DIE29_RS04180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DIE29_RS04185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DIE29_RS04200	COG0483	inositol monophosphate 1-phosphatase activity
DIE29_RS04205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DIE29_RS04215	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DIE29_RS04215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DIE29_RS04225	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DIE29_RS04235	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DIE29_RS04240	COG2833	Protein of unknown function (DUF455)
DIE29_RS04245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DIE29_RS04250	COG1333	cytochrome c biogenesis protein
DIE29_RS04255	COG2863	cytochrome
DIE29_RS04260	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DIE29_RS04280	COG2226	methyltransferase
DIE29_RS04285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DIE29_RS04295	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DIE29_RS04300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DIE29_RS04310	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DIE29_RS04315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DIE29_RS04320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIE29_RS04330	COG4942	peptidase
DIE29_RS04335	COG0793	Belongs to the peptidase S41A family
DIE29_RS04345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DIE29_RS04350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DIE29_RS04350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DIE29_RS04355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DIE29_RS04360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DIE29_RS04365	COG0406	alpha-ribazole phosphatase activity
DIE29_RS04370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DIE29_RS04380	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DIE29_RS04385	COG0312	modulator of DNA gyrase
DIE29_RS04390	COG3028	Belongs to the UPF0307 family
DIE29_RS04395	COG0521	Mo-molybdopterin cofactor biosynthetic process
DIE29_RS04400	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DIE29_RS04405	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DIE29_RS04410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DIE29_RS04415	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DIE29_RS04430	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DIE29_RS04460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DIE29_RS04465	COG1360	Flagellar Motor Protein
DIE29_RS04475	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DIE29_RS04480	COG1765	OsmC-like protein
DIE29_RS04485	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DIE29_RS04490	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DIE29_RS04495	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DIE29_RS04500	COG0316	Belongs to the HesB IscA family
DIE29_RS04505	COG0739	heme binding
DIE29_RS04510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DIE29_RS04570	COG3617	BRO family, N-terminal domain
DIE29_RS04585	COG3311	Transcriptional regulator
DIE29_RS04590	COG1569	PIN domain
DIE29_RS04610	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DIE29_RS04660	COG2132	Multicopper oxidase
DIE29_RS04670	COG5002	protein histidine kinase activity
DIE29_RS04675	COG5001	Diguanylate cyclase
DIE29_RS04675	COG3300	MHYT domain
DIE29_RS04685	COG0789	Transcriptional regulator
DIE29_RS04695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DIE29_RS04705	COG0402	S-adenosylhomocysteine deaminase activity
DIE29_RS04725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DIE29_RS04730	COG0287	Prephenate dehydrogenase
DIE29_RS04735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DIE29_RS04745	COG0776	regulation of translation
DIE29_RS04755	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DIE29_RS04790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DIE29_RS04795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DIE29_RS04800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DIE29_RS04805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DIE29_RS04810	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DIE29_RS04815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIE29_RS04815	COG0072	phenylalanine-tRNA ligase activity
DIE29_RS04820	COG0776	regulation of translation
DIE29_RS04835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DIE29_RS04840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DIE29_RS04855	COG2951	lytic endotransglycosylase activity
DIE29_RS04870	COG0714	Associated with various cellular activities
DIE29_RS04875	COG0123	including yeast histone deacetylase and acetoin utilization protein
DIE29_RS04880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DIE29_RS04885	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DIE29_RS04895	COG2850	peptidyl-arginine hydroxylation
DIE29_RS04900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DIE29_RS04940	COG1815	bacterial-type flagellum-dependent cell motility
DIE29_RS04945	COG1558	bacterial-type flagellum-dependent cell motility
DIE29_RS04950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DIE29_RS04955	COG1749	Flagellar hook protein flgE
DIE29_RS04960	COG4787	bacterial-type flagellum-dependent cell motility
DIE29_RS04970	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DIE29_RS04975	COG1706	bacterial-type flagellum-dependent cell motility
DIE29_RS04980	COG3951	Flagellar rod assembly protein muramidase FlgJ
DIE29_RS04980	COG1705	Flagellar rod assembly protein muramidase FlgJ
DIE29_RS05000	COG1684	flagellar biosynthetic protein fliR
DIE29_RS05020	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DIE29_RS05025	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DIE29_RS05060	COG1766	The M ring may be actively involved in energy transduction
DIE29_RS05075	COG1677	Flagellar hook-basal body complex protein FliE
DIE29_RS05090	COG1121	(ABC) transporter
DIE29_RS05105	COG0735	belongs to the Fur family
DIE29_RS05110	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DIE29_RS05115	COG2257	FlhB HrpN YscU SpaS Family
DIE29_RS05135	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DIE29_RS05170	COG2197	response regulator
DIE29_RS05195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DIE29_RS05215	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DIE29_RS05225	COG1238	metal cluster binding
DIE29_RS05235	COG1802	Transcriptional regulator
DIE29_RS05240	COG1840	ABC-type Fe3 transport system, periplasmic component
DIE29_RS05245	COG3842	ATPase activity
DIE29_RS05255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DIE29_RS05260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DIE29_RS05265	COG2205	protein histidine kinase activity
DIE29_RS05265	COG3850	Histidine kinase
DIE29_RS05265	COG4999	Histidine kinase
DIE29_RS05265	COG3437	response regulator, receiver
DIE29_RS05270	COG2205	protein histidine kinase activity
DIE29_RS05270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIE29_RS05280	COG0583	DNA-binding transcription factor activity
DIE29_RS05285	COG0477	Major facilitator Superfamily
DIE29_RS05290	COG1648	precorrin-2 dehydrogenase activity
DIE29_RS05290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DIE29_RS05295	COG2010	Cytochrome c
DIE29_RS05320	COG2010	Cytochrome c
DIE29_RS05345	COG0535	radical SAM domain protein
DIE29_RS05375	COG0714	Associated with various cellular activities
DIE29_RS05395	COG2010	Cytochrome c
DIE29_RS05400	COG1454	alcohol dehydrogenase
DIE29_RS05420	COG0628	permease
DIE29_RS05425	COG1253	flavin adenine dinucleotide binding
DIE29_RS05430	COG0861	Integral membrane protein TerC family
DIE29_RS05445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DIE29_RS05455	COG5002	protein histidine kinase activity
DIE29_RS05460	COG0745	RESPONSE REGULATOR receiver
DIE29_RS05465	COG5002	protein histidine kinase activity
DIE29_RS05465	COG2176	DNA-directed DNA polymerase activity
DIE29_RS05470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DIE29_RS05510	COG0688	phosphatidylethanolamine metabolic process
DIE29_RS05525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DIE29_RS05530	COG0842	Transport permease protein
DIE29_RS05530	COG1129	ABC transporter
DIE29_RS05535	COG0842	Transport permease protein
DIE29_RS05550	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DIE29_RS05555	COG1238	metal cluster binding
DIE29_RS05565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DIE29_RS05570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DIE29_RS05580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DIE29_RS05580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DIE29_RS05600	COG0723	plastoquinol--plastocyanin reductase activity
DIE29_RS05605	COG2204	response regulator
DIE29_RS05620	COG1294	oxidase, subunit
DIE29_RS05630	COG3790	cyd operon protein YbgE
DIE29_RS05640	COG0446	pyridine nucleotide-disulphide oxidoreductase
DIE29_RS05650	COG0720	synthase
DIE29_RS05665	COG0527	aspartate kinase activity
DIE29_RS05780	COG0183	Belongs to the thiolase family
DIE29_RS05785	COG2308	Evidence 4 Homologs of previously reported genes of
DIE29_RS05795	COG1162	GTPase activity
DIE29_RS05800	COG0501	Belongs to the peptidase M48B family
DIE29_RS05805	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DIE29_RS05810	COG0166	Belongs to the GPI family
DIE29_RS05820	COG0254	rRNA binding
DIE29_RS05835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DIE29_RS05835	COG0426	domain, Protein
DIE29_RS05850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DIE29_RS05855	COG2119	membrane
DIE29_RS05870	COG0501	Belongs to the peptidase M48B family
DIE29_RS05875	COG1704	LemA family
DIE29_RS05890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DIE29_RS05895	COG4660	Part of a membrane complex involved in electron transport
DIE29_RS05910	COG4656	Part of a membrane complex involved in electron transport
DIE29_RS05915	COG2878	Part of a membrane complex involved in electron transport
DIE29_RS05920	COG4657	Part of a membrane complex involved in electron transport
DIE29_RS05925	COG0167	dihydroorotate dehydrogenase activity
DIE29_RS05930	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DIE29_RS05935	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DIE29_RS05940	COG3842	ATPase activity
DIE29_RS05945	COG1178	ABC-type Fe3 transport system permease component
DIE29_RS05950	COG1858	cytochrome C peroxidase
DIE29_RS05965	COG0628	permease
DIE29_RS05970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DIE29_RS05980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DIE29_RS06000	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DIE29_RS06010	COG1518	maintenance of DNA repeat elements
DIE29_RS06015	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DIE29_RS06090	COG0829	nickel cation binding
DIE29_RS06095	COG0831	urea catabolic process
DIE29_RS06100	COG0832	Belongs to the urease beta subunit family
DIE29_RS06105	COG0804	urea catabolic process
DIE29_RS06110	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DIE29_RS06115	COG0830	nickel cation binding
DIE29_RS06120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DIE29_RS06135	COG0745	RESPONSE REGULATOR receiver
DIE29_RS06140	COG2205	protein histidine kinase activity
DIE29_RS06165	COG1752	Esterase of the alpha-beta hydrolase superfamily
DIE29_RS06170	COG1607	acyl-coa hydrolase
DIE29_RS06180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DIE29_RS06180	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DIE29_RS06185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DIE29_RS06205	COG0315	cyclic pyranopterin monophosphate synthase activity
DIE29_RS06215	COG0425	Belongs to the sulfur carrier protein TusA family
DIE29_RS06235	COG1280	lysine exporter protein (LysE YggA)
DIE29_RS06245	COG0525	valine-tRNA ligase activity
DIE29_RS06260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DIE29_RS06265	COG0795	lipopolysaccharide-transporting ATPase activity
DIE29_RS06275	COG0335	large ribosomal subunit rRNA binding
DIE29_RS06280	COG0336	Belongs to the RNA methyltransferase TrmD family
DIE29_RS06285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DIE29_RS06290	COG0228	four-way junction DNA binding
DIE29_RS06300	COG1295	ribonuclease BN
DIE29_RS06325	COG0601	transmembrane transport
DIE29_RS06330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DIE29_RS06335	COG1763	Mo-molybdopterin cofactor biosynthetic process
DIE29_RS06340	COG0303	'Molybdopterin
DIE29_RS06345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DIE29_RS06350	COG0314	molybdopterin synthase activity
DIE29_RS06360	COG0542	response to heat
DIE29_RS06370	COG4772	TonB-dependent receptor
DIE29_RS06420	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DIE29_RS06425	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
DIE29_RS06435	COG0535	radical SAM domain protein
DIE29_RS06445	COG2197	response regulator
DIE29_RS06505	COG3284	Transcriptional regulator
DIE29_RS06510	COG1012	belongs to the aldehyde dehydrogenase family
DIE29_RS06530	COG3284	Transcriptional regulator
DIE29_RS06535	COG2133	pyrroloquinoline quinone binding
DIE29_RS06550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIE29_RS06565	COG4269	membrane
DIE29_RS06570	COG0501	Belongs to the peptidase M48B family
DIE29_RS06575	COG0488	(ABC) transporter
DIE29_RS06580	COG0840	transmembrane signaling receptor activity
DIE29_RS06580	COG0840	transmembrane signaling receptor activity
DIE29_RS06590	COG0583	DNA-binding transcription factor activity
DIE29_RS06615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DIE29_RS06615	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DIE29_RS06620	COG0509	glycine decarboxylation via glycine cleavage system
DIE29_RS06625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DIE29_RS06690	COG0613	PHP domain protein
DIE29_RS06695	COG0009	L-threonylcarbamoyladenylate synthase
DIE29_RS06700	COG1994	Peptidase M50
DIE29_RS06705	COG0180	Tryptophanyl-tRNA synthetase
DIE29_RS06710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DIE29_RS06715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DIE29_RS06720	COG1187	pseudouridine synthase activity
DIE29_RS06740	COG0504	CTP synthase activity
DIE29_RS06745	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DIE29_RS06750	COG0148	phosphopyruvate hydratase activity
DIE29_RS06755	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DIE29_RS06765	COG0791	NLP P60 protein
DIE29_RS06780	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DIE29_RS06790	COG0306	phosphate transporter
DIE29_RS06805	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DIE29_RS06815	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DIE29_RS06825	COG1562	ergosterol biosynthetic process
DIE29_RS06830	COG1136	(ABC) transporter
DIE29_RS06835	COG0577	efflux transmembrane transporter activity
DIE29_RS06850	COG0515	serine threonine protein kinase
DIE29_RS06850	COG2815	serine threonine protein kinase
DIE29_RS06855	COG2862	Uncharacterized protein family, UPF0114
DIE29_RS06860	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DIE29_RS06870	COG0052	Belongs to the universal ribosomal protein uS2 family
DIE29_RS06875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DIE29_RS06880	COG0528	UMP kinase activity
DIE29_RS06885	COG0233	cytoplasmic translational termination
DIE29_RS06890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DIE29_RS06895	COG0575	Belongs to the CDS family
DIE29_RS06900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DIE29_RS06920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DIE29_RS06925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DIE29_RS06930	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DIE29_RS06935	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DIE29_RS06940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DIE29_RS06950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DIE29_RS07000	COG5001	Diguanylate cyclase
DIE29_RS07000	COG5002	protein histidine kinase activity
DIE29_RS07010	COG4372	Transposase
DIE29_RS07035	COG0587	DNA-directed DNA polymerase activity
DIE29_RS07040	COG1067	ATP-dependent peptidase activity
DIE29_RS07045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DIE29_RS07065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DIE29_RS07085	COG1388	LysM domain
DIE29_RS07085	COG0741	lytic transglycosylase activity
DIE29_RS07090	COG4251	negative regulation of phosphorylation
DIE29_RS07090	COG3706	GGDEF domain
DIE29_RS07090	COG5001	Diguanylate cyclase
DIE29_RS07090	COG2203	Gaf domain
DIE29_RS07100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIE29_RS07110	COG0328	RNA-DNA hybrid ribonuclease activity
DIE29_RS07120	COG0579	oxidoreductase
DIE29_RS07125	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DIE29_RS07125	COG0617	tRNA 3'-terminal CCA addition
DIE29_RS07125	COG0517	IMP dehydrogenase activity
DIE29_RS07140	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DIE29_RS07160	COG0039	L-malate dehydrogenase activity
DIE29_RS07165	COG2188	Transcriptional regulator
DIE29_RS07180	COG1053	succinate dehydrogenase
DIE29_RS07185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DIE29_RS07190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DIE29_RS07195	COG0372	Belongs to the citrate synthase family
DIE29_RS07200	COG0567	Dehydrogenase, E1 component
DIE29_RS07205	COG0508	dehydrogenase complex catalyzes the overall conversion of
DIE29_RS07210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DIE29_RS07215	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DIE29_RS07230	COG1199	ATP-dependent helicase activity
DIE29_RS07235	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DIE29_RS07240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DIE29_RS07250	COG2914	Belongs to the UPF0125 (RnfH) family
DIE29_RS07265	COG0519	Catalyzes the synthesis of GMP from XMP
DIE29_RS07265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DIE29_RS07280	COG4372	Transposase
DIE29_RS07315	COG3012	SEC-C Motif Domain Protein
DIE29_RS07315	COG3318	Belongs to the UPF0149 family
DIE29_RS07325	COG0727	PFAM Uncharacterised protein family (UPF0153)
DIE29_RS07335	COG2501	S4 domain
DIE29_RS07355	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DIE29_RS07365	COG0483	inositol monophosphate 1-phosphatase activity
DIE29_RS07375	COG1045	serine acetyltransferase
DIE29_RS07385	COG1104	cysteine desulfurase activity
DIE29_RS07390	COG1104	cysteine desulfurase activity
DIE29_RS07395	COG0822	iron-sulfur transferase activity
DIE29_RS07405	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DIE29_RS07410	COG0443	Heat shock 70 kDa protein
DIE29_RS07415	COG0633	Ferredoxin
DIE29_RS07425	COG0386	Belongs to the glutathione peroxidase family
DIE29_RS07430	COG0784	Response regulator, receiver
DIE29_RS07440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DIE29_RS07450	COG2171	N-acyltransferase activity
DIE29_RS07455	COG0436	Aminotransferase
DIE29_RS07460	COG1196	nuclear chromosome segregation
DIE29_RS07470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DIE29_RS07475	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DIE29_RS07490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DIE29_RS07500	COG0583	DNA-binding transcription factor activity
DIE29_RS07510	COG1573	uracil-dna glycosylase
DIE29_RS07520	COG1214	PFAM Peptidase M22, glycoprotease
DIE29_RS07545	COG2917	probably involved in intracellular septation
DIE29_RS07550	COG2350	Protein conserved in bacteria
DIE29_RS07560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DIE29_RS07565	COG1960	acyl-CoA dehydrogenase activity
DIE29_RS07585	COG1309	transcriptional regulator
DIE29_RS07590	COG0728	peptidoglycan biosynthetic process
DIE29_RS07595	COG1881	PFAM PEBP family protein
DIE29_RS07600	COG0205	6-phosphofructokinase activity
DIE29_RS07605	COG0563	adenylate kinase activity
DIE29_RS07610	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DIE29_RS07615	COG1663	tetraacyldisaccharide 4'-kinase activity
DIE29_RS07620	COG0848	biopolymer transport protein
DIE29_RS07625	COG0811	peptide transport
DIE29_RS07630	COG1570	exodeoxyribonuclease VII activity
DIE29_RS07640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DIE29_RS07645	COG0084	hydrolase, TatD family'
DIE29_RS07655	COG0318	PFAM AMP-dependent synthetase and ligase
DIE29_RS07670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DIE29_RS07675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DIE29_RS07680	COG0248	Ppx GppA phosphatase
DIE29_RS07685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DIE29_RS07690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DIE29_RS07700	COG3228	Belongs to the MtfA family
DIE29_RS07715	COG4372	Transposase
DIE29_RS07740	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DIE29_RS07745	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DIE29_RS07770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DIE29_RS07775	COG1278	Cold shock
DIE29_RS07780	COG0513	Belongs to the DEAD box helicase family
DIE29_RS07790	COG2866	Carboxypeptidase
DIE29_RS07795	COG3022	response to hydroperoxide
DIE29_RS07805	COG0156	8-amino-7-oxononanoate synthase activity
DIE29_RS07810	COG2267	carboxylic ester hydrolase activity
DIE29_RS07815	COG2226	methyltransferase
DIE29_RS07820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DIE29_RS07825	COG0471	metal ion transport
DIE29_RS07825	COG3273	potassium ion transport
DIE29_RS07830	COG2703	oxygen carrier activity
DIE29_RS07835	COG0826	peptidase U32
DIE29_RS07850	COG4372	Transposase
DIE29_RS07860	COG0826	peptidase U32
DIE29_RS07865	COG2900	Belongs to the SlyX family
DIE29_RS07870	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DIE29_RS07875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DIE29_RS07880	COG0560	Phosphoserine phosphatase
DIE29_RS07890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DIE29_RS07900	COG2200	EAL domain
DIE29_RS07905	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DIE29_RS07910	COG1473	amidohydrolase
DIE29_RS07925	COG1305	Transglutaminase-like
DIE29_RS07950	COG0659	secondary active sulfate transmembrane transporter activity
DIE29_RS07970	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
DIE29_RS07990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DIE29_RS08010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DIE29_RS08050	COG4657	Part of a membrane complex involved in electron transport
DIE29_RS08055	COG2878	Part of a membrane complex involved in electron transport
DIE29_RS08060	COG4656	Part of a membrane complex involved in electron transport
DIE29_RS08065	COG4658	electron transport chain
DIE29_RS08070	COG4659	FMN binding
DIE29_RS08130	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
DIE29_RS08180	COG0446	pyridine nucleotide-disulphide oxidoreductase
DIE29_RS08190	COG0084	hydrolase, TatD family'
DIE29_RS08205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DIE29_RS08210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DIE29_RS08215	COG0354	folic acid binding
DIE29_RS08235	COG1376	ErfK ybiS ycfS ynhG family protein
DIE29_RS08245	COG4191	Histidine kinase
DIE29_RS08250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DIE29_RS08260	COG0071	Belongs to the small heat shock protein (HSP20) family
DIE29_RS08265	COG0501	Belongs to the peptidase M48B family
DIE29_RS08270	COG1666	GTP binding
DIE29_RS08275	COG3123	guanosine phosphorylase activity
DIE29_RS08285	COG0137	argininosuccinate synthase activity
DIE29_RS08290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DIE29_RS08295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DIE29_RS08305	COG0268	Binds directly to 16S ribosomal RNA
DIE29_RS08310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DIE29_RS08320	COG0643	Histidine kinase
DIE29_RS08320	COG2198	Histidine kinase
DIE29_RS08320	COG0784	Response regulator, receiver
DIE29_RS08325	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DIE29_RS08330	COG0745	RESPONSE REGULATOR receiver
DIE29_RS08335	COG0784	Response regulator, receiver
DIE29_RS08335	COG0835	chemotaxis
DIE29_RS08340	COG0835	chemotaxis
DIE29_RS08340	COG0784	Response regulator, receiver
DIE29_RS08345	COG2201	protein-glutamate methylesterase activity
DIE29_RS08355	COG0840	transmembrane signaling receptor activity
DIE29_RS08355	COG0840	transmembrane signaling receptor activity
DIE29_RS08360	COG2198	Histidine kinase
DIE29_RS08360	COG0643	Histidine kinase
DIE29_RS08370	COG1360	Flagellar Motor Protein
DIE29_RS08375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DIE29_RS08410	COG3845	ABC transporter
DIE29_RS08415	COG4603	Belongs to the binding-protein-dependent transport system permease family
DIE29_RS08420	COG1079	Belongs to the binding-protein-dependent transport system permease family
DIE29_RS08430	COG0402	S-adenosylhomocysteine deaminase activity
DIE29_RS08455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DIE29_RS08465	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DIE29_RS08470	COG4181	ATPase activity
DIE29_RS08485	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DIE29_RS08500	COG0840	transmembrane signaling receptor activity
DIE29_RS08515	COG2202	Pas domain
DIE29_RS08515	COG2205	protein histidine kinase activity
DIE29_RS08530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIE29_RS08530	COG1042	CoA-binding domain protein
DIE29_RS08530	COG0045	succinate-CoA ligase (ADP-forming) activity
DIE29_RS08535	COG0676	glucose-6-phosphate 1-epimerase activity
DIE29_RS08540	COG2183	response to ionizing radiation
DIE29_RS08545	COG1393	Belongs to the ArsC family
DIE29_RS08550	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DIE29_RS08560	COG0850	regulation of cytokinetic process
DIE29_RS08570	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DIE29_RS08575	COG0617	tRNA 3'-terminal CCA addition
DIE29_RS08590	COG1428	Deoxynucleoside kinase
DIE29_RS08595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DIE29_RS08600	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DIE29_RS08610	COG0308	aminopeptidase N
DIE29_RS08625	COG0028	Belongs to the TPP enzyme family
DIE29_RS08635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DIE29_RS08640	COG1183	phosphatidylcholine synthase activity
DIE29_RS08645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DIE29_RS08675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DIE29_RS08685	COG3437	response regulator, receiver
DIE29_RS08690	COG0657	acetylesterase activity
DIE29_RS08720	COG2194	sulfuric ester hydrolase activity
DIE29_RS08735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DIE29_RS08740	COG0322	excinuclease ABC activity
DIE29_RS08745	COG1472	Belongs to the glycosyl hydrolase 3 family
DIE29_RS08750	COG0736	holo-[acyl-carrier-protein] synthase activity
DIE29_RS08755	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DIE29_RS08760	COG1381	Involved in DNA repair and RecF pathway recombination
DIE29_RS08765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DIE29_RS08770	COG0571	ribonuclease III activity
DIE29_RS08780	COG0681	Belongs to the peptidase S26 family
DIE29_RS08785	COG0481	GTPase activity
DIE29_RS08795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DIE29_RS08820	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DIE29_RS08830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DIE29_RS08835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DIE29_RS08850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIE29_RS08855	COG0416	fatty acid biosynthetic process
DIE29_RS08860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DIE29_RS08865	COG1399	metal-binding, possibly nucleic acid-binding protein
DIE29_RS08870	COG0424	maF-like protein
DIE29_RS08875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DIE29_RS08890	COG1530	ribonuclease E activity
DIE29_RS08895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DIE29_RS08900	COG0556	nucleotide-excision repair
DIE29_RS08925	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DIE29_RS08935	COG4263	nitrous-oxide reductase activity
DIE29_RS08960	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DIE29_RS08985	COG3245	cytochrome
DIE29_RS08990	COG0252	asparaginase activity
DIE29_RS09000	COG1115	amino acid carrier protein
DIE29_RS09025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DIE29_RS09030	COG1185	polyribonucleotide nucleotidyltransferase activity
DIE29_RS09035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DIE29_RS09040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DIE29_RS09045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DIE29_RS09050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DIE29_RS09055	COG2251	uridine kinase activity
DIE29_RS09055	COG0195	Participates in both transcription termination and antitermination
DIE29_RS09060	COG0779	Required for maturation of 30S ribosomal subunits
DIE29_RS09070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DIE29_RS09075	COG0824	Thioesterase
DIE29_RS09090	COG1999	signal sequence binding
DIE29_RS09105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DIE29_RS09105	COG0047	phosphoribosylformylglycinamidine synthase activity
DIE29_RS09120	COG0739	heme binding
DIE29_RS09130	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DIE29_RS09140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DIE29_RS09165	COG1136	(ABC) transporter
DIE29_RS09180	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DIE29_RS09200	COG1196	nuclear chromosome segregation
DIE29_RS09215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIE29_RS09235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DIE29_RS09240	COG2354	Protein conserved in bacteria
DIE29_RS09245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DIE29_RS09245	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DIE29_RS09260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DIE29_RS09265	COG0494	nUDIX hydrolase
DIE29_RS09285	COG0776	regulation of translation
DIE29_RS09290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DIE29_RS09295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DIE29_RS09300	COG0740	serine-type endopeptidase activity
DIE29_RS09305	COG0544	peptidyl-prolyl cis-trans isomerase activity
DIE29_RS09310	COG2766	serine protein kinase
DIE29_RS09315	COG2718	Belongs to the UPF0229 family
DIE29_RS09320	COG2719	SpoVR family
DIE29_RS09330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DIE29_RS09330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DIE29_RS09355	COG1490	D-aminoacyl-tRNA deacylase activity
DIE29_RS09365	COG0436	Aminotransferase
DIE29_RS09375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DIE29_RS09380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DIE29_RS09395	COG0791	NLP P60 protein
DIE29_RS09405	COG1840	ABC-type Fe3 transport system, periplasmic component
DIE29_RS09410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DIE29_RS09420	COG0142	geranyltranstransferase activity
DIE29_RS09425	COG0584	glycerophosphoryl diester phosphodiesterase
DIE29_RS09440	COG0667	Aldo Keto reductase
DIE29_RS09445	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DIE29_RS09450	COG0513	Belongs to the DEAD box helicase family
DIE29_RS09495	COG0631	protein serine/threonine phosphatase activity
DIE29_RS09500	COG0247	lactate metabolic process
DIE29_RS09505	COG0277	FAD linked oxidase domain protein
DIE29_RS09510	COG0277	FAD linked oxidase domain protein
DIE29_RS09515	COG3622	Belongs to the hyi family
DIE29_RS09520	COG0659	secondary active sulfate transmembrane transporter activity
DIE29_RS09525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DIE29_RS09530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DIE29_RS09535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DIE29_RS09540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DIE29_RS09560	COG0577	efflux transmembrane transporter activity
DIE29_RS09560	COG1136	(ABC) transporter
DIE29_RS09575	COG1320	monovalent cation:proton antiporter activity
DIE29_RS09580	COG2212	antiporter activity
DIE29_RS09585	COG1863	multisubunit Na H antiporter MnhE subunit
DIE29_RS09590	COG0651	ATP synthesis coupled electron transport
DIE29_RS09595	COG1006	Multisubunit Na H antiporter MnhC subunit
DIE29_RS09600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DIE29_RS09600	COG2111	Na H antiporter
DIE29_RS09605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DIE29_RS09615	COG0604	alcohol dehydrogenase
DIE29_RS09625	COG2271	Major facilitator Superfamily
DIE29_RS09630	COG1704	LemA family
DIE29_RS09640	COG0488	(ABC) transporter
DIE29_RS09660	COG0741	lytic transglycosylase activity
DIE29_RS09675	COG2204	response regulator
DIE29_RS09685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DIE29_RS09715	COG5001	Diguanylate cyclase
DIE29_RS09715	COG5002	protein histidine kinase activity
DIE29_RS09715	COG3447	MASE1 domain protein
DIE29_RS09735	COG2703	oxygen carrier activity
DIE29_RS09745	COG0784	Response regulator, receiver
DIE29_RS09745	COG2198	Histidine kinase
DIE29_RS09745	COG5002	protein histidine kinase activity
DIE29_RS09755	COG0326	Molecular chaperone. Has ATPase activity
DIE29_RS09775	COG2267	carboxylic ester hydrolase activity
DIE29_RS09790	COG1230	cation diffusion facilitator family transporter
DIE29_RS09805	COG3259	Nickel-dependent hydrogenase
DIE29_RS09810	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
DIE29_RS09815	COG3383	formate dehydrogenase (NAD+) activity
DIE29_RS09820	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DIE29_RS09830	COG0537	adenosine 5'-monophosphoramidase activity
DIE29_RS09845	COG1007	ATP synthesis coupled electron transport
DIE29_RS09860	COG0713	ATP synthesis coupled electron transport
DIE29_RS09870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIE29_RS09875	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DIE29_RS09880	COG1034	ATP synthesis coupled electron transport
DIE29_RS09885	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DIE29_RS09895	COG0649	NAD binding
DIE29_RS09900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIE29_RS09905	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIE29_RS09910	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIE29_RS09925	COG0149	triose-phosphate isomerase activity
DIE29_RS09945	COG0640	Transcriptional regulator
DIE29_RS09950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DIE29_RS09970	COG0798	PFAM Bile acid sodium symporter
DIE29_RS09985	COG0701	Predicted permease
DIE29_RS10010	COG0573	inorganic phosphate transmembrane transporter activity
DIE29_RS10025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DIE29_RS10035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DIE29_RS10040	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DIE29_RS10055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DIE29_RS10060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DIE29_RS10065	COG0505	Belongs to the CarA family
DIE29_RS10070	COG5002	protein histidine kinase activity
DIE29_RS10070	COG2205	protein histidine kinase activity
DIE29_RS10070	COG0784	Response regulator, receiver
DIE29_RS10075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DIE29_RS10080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DIE29_RS10085	COG0735	belongs to the Fur family
DIE29_RS10090	COG0497	DNA recombination
DIE29_RS10095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DIE29_RS10100	COG1420	regulation of RNA biosynthetic process
DIE29_RS10105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DIE29_RS10115	COG0515	serine threonine protein kinase
DIE29_RS10115	COG2815	serine threonine protein kinase
DIE29_RS10120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DIE29_RS10125	COG0443	Heat shock 70 kDa protein
DIE29_RS10130	COG0484	heat shock protein binding
DIE29_RS10140	COG0215	cysteine-tRNA ligase activity
DIE29_RS10155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DIE29_RS10160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DIE29_RS10165	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DIE29_RS10190	COG0285	dihydrofolate synthase activity
DIE29_RS10195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DIE29_RS10200	COG0159	tryptophan synthase activity
DIE29_RS10205	COG0133	tryptophan synthase activity
DIE29_RS10210	COG0135	phosphoribosylanthranilate isomerase activity
DIE29_RS10215	COG0101	tRNA pseudouridine synthase activity
DIE29_RS10235	COG0473	3-isopropylmalate dehydrogenase activity
DIE29_RS10240	COG0066	3-isopropylmalate dehydratase activity
DIE29_RS10245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DIE29_RS10250	COG0501	Belongs to the peptidase M48B family
DIE29_RS10255	COG2814	Major facilitator Superfamily
DIE29_RS10260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DIE29_RS10265	COG0440	acetolactate synthase activity
DIE29_RS10270	COG0028	Belongs to the TPP enzyme family
DIE29_RS10275	COG0318	PFAM AMP-dependent synthetase and ligase
DIE29_RS10295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DIE29_RS10300	COG1250	3-hydroxyacyl-CoA dehydrogenase
DIE29_RS10335	COG0277	FAD linked oxidase domain protein
DIE29_RS10340	COG1752	Esterase of the alpha-beta hydrolase superfamily
DIE29_RS10345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DIE29_RS10350	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
DIE29_RS10360	COG1028	Short-chain dehydrogenase reductase Sdr
DIE29_RS10365	COG3243	poly(R)-hydroxyalkanoic acid synthase
DIE29_RS10380	COG0564	pseudouridine synthase activity
DIE29_RS10390	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DIE29_RS10390	COG0662	Cupin 2, conserved barrel domain protein
DIE29_RS10405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DIE29_RS10410	COG0802	atpase or kinase
DIE29_RS10415	COG0860	N-Acetylmuramoyl-L-alanine amidase
DIE29_RS10420	COG0196	riboflavin kinase activity
DIE29_RS10425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DIE29_RS10430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DIE29_RS10435	COG1047	Peptidyl-prolyl cis-trans
DIE29_RS10440	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DIE29_RS10450	COG1722	exodeoxyribonuclease VII activity
DIE29_RS10455	COG0142	geranyltranstransferase activity
DIE29_RS10460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DIE29_RS10465	COG1469	GTP cyclohydrolase I activity
DIE29_RS10470	COG2030	dehydratase
DIE29_RS10510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DIE29_RS10520	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DIE29_RS10530	COG2217	Heavy metal translocating P-type atpase
DIE29_RS10545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DIE29_RS10550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DIE29_RS10575	COG3243	poly(R)-hydroxyalkanoic acid synthase
DIE29_RS10620	COG3278	Belongs to the heme-copper respiratory oxidase family
DIE29_RS10630	COG2217	Heavy metal translocating P-type atpase
DIE29_RS10645	COG0489	protein tyrosine kinase activity
DIE29_RS10650	COG3047	cAMP biosynthetic process
DIE29_RS10650	COG2885	chlorophyll binding
DIE29_RS10655	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIE29_RS10655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIE29_RS10660	COG0659	secondary active sulfate transmembrane transporter activity
DIE29_RS10665	COG1254	Belongs to the acylphosphatase family
DIE29_RS10680	COG0281	malic enzyme
DIE29_RS10680	COG0280	phosphate acetyltransferase
DIE29_RS10695	COG0210	DNA helicase
DIE29_RS10705	COG0495	leucyl-tRNA aminoacylation
DIE29_RS10715	COG1466	dna polymerase III delta subunit
DIE29_RS10720	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DIE29_RS10730	COG4974	Belongs to the 'phage' integrase family
DIE29_RS10735	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DIE29_RS10745	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DIE29_RS10750	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DIE29_RS10755	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DIE29_RS10780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DIE29_RS10790	COG4536	flavin adenine dinucleotide binding
DIE29_RS10805	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DIE29_RS10820	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DIE29_RS10850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DIE29_RS10890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DIE29_RS10915	COG1216	Glycosyl transferase, family 2
DIE29_RS10915	COG1442	glycosyl transferase family 8
DIE29_RS10920	COG0438	transferase activity, transferring glycosyl groups
DIE29_RS10920	COG0297	glycogen (starch) synthase activity
DIE29_RS10925	COG1216	Glycosyl transferase, family 2
DIE29_RS10950	COG0438	transferase activity, transferring glycosyl groups
DIE29_RS10955	COG0297	glycogen (starch) synthase activity
DIE29_RS10960	COG0367	asparagine synthase
DIE29_RS10965	COG0438	transferase activity, transferring glycosyl groups
DIE29_RS10995	COG3267	Type II secretory pathway component ExeA
DIE29_RS10995	COG3409	Peptidoglycan-binding domain 1 protein
DIE29_RS11005	COG0489	protein tyrosine kinase activity
DIE29_RS11030	COG0577	efflux transmembrane transporter activity
DIE29_RS11030	COG1136	(ABC) transporter
DIE29_RS11050	COG0300	oxidoreductase activity
DIE29_RS11070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DIE29_RS11085	COG1469	GTP cyclohydrolase I activity
DIE29_RS11100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DIE29_RS11135	COG3609	addiction module antidote protein, CC2985 family
DIE29_RS11165	COG0514	ATP-dependent DNA helicase (RecQ)
DIE29_RS11170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DIE29_RS11180	COG0134	indole-3-glycerol-phosphate synthase activity
DIE29_RS11185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DIE29_RS11195	COG3246	L-lysine catabolic process to acetate
DIE29_RS11200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DIE29_RS11210	COG0546	phosphoglycolate phosphatase activity
DIE29_RS11215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DIE29_RS11220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DIE29_RS11230	COG1716	ATPase activity
DIE29_RS11235	COG0631	protein serine/threonine phosphatase activity
DIE29_RS11240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DIE29_RS11245	COG0045	succinate-CoA ligase (ADP-forming) activity
DIE29_RS11260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DIE29_RS11270	COG0805	protein transport
DIE29_RS11275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DIE29_RS11280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DIE29_RS11290	COG0140	phosphoribosyl-ATP diphosphatase activity
DIE29_RS11295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DIE29_RS11300	COG0107	imidazoleglycerol-phosphate synthase activity
DIE29_RS11305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DIE29_RS11310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DIE29_RS11315	COG0131	Imidazoleglycerol-phosphate dehydratase
DIE29_RS11320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DIE29_RS11325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DIE29_RS11330	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DIE29_RS11335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DIE29_RS11345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DIE29_RS11355	COG0842	Transport permease protein
DIE29_RS11360	COG1131	(ABC) transporter
DIE29_RS11380	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DIE29_RS11385	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DIE29_RS11390	COG1127	ABC transporter
DIE29_RS11400	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DIE29_RS11410	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DIE29_RS11415	COG1024	Enoyl-CoA hydratase
DIE29_RS11425	COG0204	Acyl-transferase
DIE29_RS11430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DIE29_RS11435	COG0751	glycine-tRNA ligase activity
DIE29_RS11440	COG0752	glycyl-tRNA synthetase alpha subunit
DIE29_RS11445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DIE29_RS11450	COG4535	Mg2 and Co2 transporter CorC
DIE29_RS11455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DIE29_RS11460	COG1702	phosphate starvation-inducible protein PhoH
DIE29_RS11465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DIE29_RS11515	COG5433	transposase activity
DIE29_RS11525	COG2154	pterin-4-alpha-carbinolamine dehydratase
DIE29_RS11530	COG0009	L-threonylcarbamoyladenylate synthase
DIE29_RS11535	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DIE29_RS11540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DIE29_RS11545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DIE29_RS11565	COG4566	intracellular signal transduction
DIE29_RS11580	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DIE29_RS11585	COG0508	dehydrogenase complex catalyzes the overall conversion of
DIE29_RS11590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DIE29_RS11610	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DIE29_RS11660	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DIE29_RS11665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DIE29_RS11675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DIE29_RS11680	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DIE29_RS11685	COG1674	ftsk spoiiie
DIE29_RS11695	COG0492	ferredoxin-NADP+ reductase activity
DIE29_RS11700	COG2840	Smr protein MutS2
DIE29_RS11710	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DIE29_RS11710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DIE29_RS11720	COG0717	Belongs to the dCTP deaminase family
DIE29_RS11725	COG0583	DNA-binding transcription factor activity
DIE29_RS11730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DIE29_RS11740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DIE29_RS11760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DIE29_RS11770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DIE29_RS11775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DIE29_RS11780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DIE29_RS11785	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DIE29_RS11795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DIE29_RS11800	COG0006	proline dipeptidase activity
DIE29_RS11805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DIE29_RS11825	COG0151	Belongs to the GarS family
DIE29_RS11830	COG0408	coproporphyrinogen oxidase activity
DIE29_RS11840	COG2959	enzyme of heme biosynthesis
DIE29_RS11850	COG0181	hydroxymethylbilane synthase activity
DIE29_RS11855	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DIE29_RS11895	COG4970	Tfp pilus assembly protein FimT
DIE29_RS11910	COG0165	Argininosuccinate lyase
DIE29_RS11915	COG3001	Fructosamine kinase
DIE29_RS11940	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DIE29_RS11950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DIE29_RS11955	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DIE29_RS11965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DIE29_RS11990	COG0631	protein serine/threonine phosphatase activity
DIE29_RS11995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DIE29_RS12000	COG0653	protein targeting
DIE29_RS12015	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DIE29_RS12020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DIE29_RS12030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DIE29_RS12035	COG1181	Belongs to the D-alanine--D-alanine ligase family
DIE29_RS12040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DIE29_RS12045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DIE29_RS12050	COG0772	Belongs to the SEDS family
DIE29_RS12055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DIE29_RS12060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DIE29_RS12065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DIE29_RS12070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DIE29_RS12085	COG0275	rRNA processing
DIE29_RS12090	COG2001	Belongs to the MraZ family
DIE29_RS12105	COG0418	dihydroorotase activity
DIE29_RS12115	COG0792	nuclease activity
DIE29_RS12120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DIE29_RS12125	COG2823	Periplasmic or secreted lipoprotein
DIE29_RS12130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DIE29_RS12205	COG3846	protein secretion by the type IV secretion system
DIE29_RS12230	COG0556	nucleotide-excision repair
DIE29_RS12245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DIE29_RS12265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DIE29_RS12275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DIE29_RS12280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DIE29_RS12285	COG0511	ligase activity, forming carbon-carbon bonds
DIE29_RS12290	COG0439	Biotin carboxylase
DIE29_RS12295	COG2264	protein methyltransferase activity
DIE29_RS12315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DIE29_RS12360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DIE29_RS12385	COG1450	Type ii and iii secretion system protein
DIE29_RS12415	COG2165	general secretion pathway protein
DIE29_RS12420	COG4970	Tfp pilus assembly protein FimT
DIE29_RS12430	COG1459	type II secretion system
DIE29_RS12435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DIE29_RS12450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DIE29_RS12460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DIE29_RS12465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DIE29_RS12475	COG1538	Outer membrane efflux protein
DIE29_RS12480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIE29_RS12485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DIE29_RS12505	COG1918	ferrous iron import across plasma membrane
DIE29_RS12510	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DIE29_RS12525	COG0351	phosphomethylpyrimidine kinase
DIE29_RS12530	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DIE29_RS12550	COG3150	esterase
DIE29_RS12555	COG2226	methyltransferase
DIE29_RS12565	COG0557	exoribonuclease II activity
DIE29_RS12575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DIE29_RS12580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DIE29_RS12585	COG2239	Acts as a magnesium transporter
DIE29_RS12670	COG0305	Participates in initiation and elongation during chromosome replication
DIE29_RS12675	COG0359	binds to the 23S rRNA
DIE29_RS12680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DIE29_RS12690	COG0360	Binds together with S18 to 16S ribosomal RNA
DIE29_RS12695	COG1643	Atp-dependent helicase
DIE29_RS12700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DIE29_RS12705	COG0668	transmembrane transport
DIE29_RS12710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DIE29_RS12720	COG1968	undecaprenyl-diphosphatase activity
DIE29_RS12725	COG2211	Major facilitator Superfamily
DIE29_RS12730	COG1187	pseudouridine synthase activity
DIE29_RS12735	COG1320	monovalent cation:proton antiporter activity
DIE29_RS12740	COG2212	antiporter activity
DIE29_RS12750	COG0651	ATP synthesis coupled electron transport
DIE29_RS12755	COG1006	Multisubunit Na H antiporter MnhC subunit
DIE29_RS12760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DIE29_RS12760	COG2111	Na H antiporter
DIE29_RS12765	COG1414	Transcriptional regulator
DIE29_RS12780	COG0281	malic enzyme
DIE29_RS12780	COG0280	phosphate acetyltransferase
DIE29_RS12785	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DIE29_RS12790	COG0436	Aminotransferase
DIE29_RS12795	COG0741	lytic transglycosylase activity
DIE29_RS12800	COG3023	N-Acetylmuramoyl-L-alanine amidase
DIE29_RS12810	COG0778	Nitroreductase
DIE29_RS12815	COG1797	cobyrinic acid a,c-diamide synthase activity
DIE29_RS12820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DIE29_RS12820	COG1648	precorrin-2 dehydrogenase activity
DIE29_RS12825	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DIE29_RS12830	COG4139	cobalamin transport
DIE29_RS12835	COG4206	TonB-dependent receptor
DIE29_RS12845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DIE29_RS12850	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DIE29_RS12855	COG0406	alpha-ribazole phosphatase activity
DIE29_RS12860	COG1132	(ABC) transporter
DIE29_RS12865	COG0726	polysaccharide deacetylase
DIE29_RS12870	COG0438	transferase activity, transferring glycosyl groups
DIE29_RS12875	COG0438	transferase activity, transferring glycosyl groups
DIE29_RS12890	COG0438	transferase activity, transferring glycosyl groups
DIE29_RS12895	COG0438	transferase activity, transferring glycosyl groups
DIE29_RS12920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DIE29_RS12920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DIE29_RS12935	COG4636	protein conserved in cyanobacteria
DIE29_RS12940	COG0367	asparagine synthase
DIE29_RS12960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DIE29_RS12970	COG0110	maltose O-acetyltransferase activity
DIE29_RS13015	COG0436	Aminotransferase
DIE29_RS13020	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DIE29_RS13030	COG2084	Dehydrogenase
DIE29_RS13035	COG2084	Dehydrogenase
DIE29_RS13040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DIE29_RS13045	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DIE29_RS13065	COG1215	transferase activity, transferring glycosyl groups
DIE29_RS13075	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DIE29_RS13080	COG0457	Tetratricopeptide repeat
DIE29_RS13090	COG1032	radical SAM domain protein
DIE29_RS13115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DIE29_RS13125	COG3088	subunit of a heme lyase
DIE29_RS13130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DIE29_RS13140	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DIE29_RS13160	COG4133	protoheme IX ABC transporter activity
DIE29_RS13165	COG3005	denitrification pathway
DIE29_RS13170	COG3043	anaerobic respiration
DIE29_RS13175	COG0348	domain, Protein
DIE29_RS13180	COG0437	4 iron, 4 sulfur cluster binding
DIE29_RS13185	COG0243	molybdopterin cofactor binding
DIE29_RS13195	COG0437	4 iron, 4 sulfur cluster binding
DIE29_RS13200	COG2197	response regulator
DIE29_RS13205	COG3850	Histidine kinase
DIE29_RS13215	COG2176	DNA-directed DNA polymerase activity
DIE29_RS13215	COG5002	protein histidine kinase activity
DIE29_RS13225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DIE29_RS13230	COG1758	RNA polymerase activity
DIE29_RS13235	COG0194	GDP metabolic process
DIE29_RS13240	COG1561	YicC-like family, N-terminal region
DIE29_RS13250	COG0631	protein serine/threonine phosphatase activity
DIE29_RS13255	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DIE29_RS13260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DIE29_RS13265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DIE29_RS13270	COG0616	signal peptide processing
DIE29_RS13275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DIE29_RS13280	COG2022	thiamine diphosphate biosynthetic process
DIE29_RS13310	COG0745	RESPONSE REGULATOR receiver
DIE29_RS13320	COG2226	methyltransferase
DIE29_RS13335	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DIE29_RS13340	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DIE29_RS13345	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DIE29_RS13350	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DIE29_RS13355	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DIE29_RS13360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DIE29_RS13370	COG0356	it plays a direct role in the translocation of protons across the membrane
DIE29_RS13380	COG1475	DNA binding
DIE29_RS13385	COG1192	Involved in chromosome partitioning
DIE29_RS13390	COG0357	Ribosomal RNA small subunit methyltransferase G
DIE29_RS13395	COG0445	tRNA wobble uridine modification
DIE29_RS13400	COG0697	spore germination
DIE29_RS13405	COG2207	Transcriptional regulator
DIE29_RS13415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DIE29_RS13420	COG0163	prenyltransferase activity
DIE29_RS13450	COG0420	3'-5' exonuclease activity
DIE29_RS13455	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DIE29_RS13465	COG4774	siderophore transport
DIE29_RS13495	COG4771	TonB-dependent receptor
DIE29_RS13500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DIE29_RS13525	COG4771	TonB-dependent receptor
DIE29_RS13545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DIE29_RS13565	COG4771	TonB-dependent receptor
DIE29_RS13575	COG0577	efflux transmembrane transporter activity
DIE29_RS13575	COG1136	(ABC) transporter
DIE29_RS13580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DIE29_RS13585	COG0735	belongs to the Fur family
DIE29_RS13630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIE29_RS13675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DIE29_RS13680	COG1074	ATP-dependent DNA helicase activity
DIE29_RS13685	COG0840	transmembrane signaling receptor activity
DIE29_RS13710	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DIE29_RS13715	COG2814	Major facilitator Superfamily
DIE29_RS13725	COG1363	Peptidase, m42
DIE29_RS13730	COG0189	ligase activity
DIE29_RS13730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DIE29_RS13740	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DIE29_RS13745	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DIE29_RS13750	COG1546	Belongs to the CinA family
DIE29_RS13755	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DIE29_RS13760	COG2137	regulation of response to DNA damage stimulus
DIE29_RS13765	COG1137	ATPase activity
DIE29_RS13770	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DIE29_RS13775	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DIE29_RS13785	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DIE29_RS13795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DIE29_RS13800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIE29_RS13805	COG5001	Diguanylate cyclase
DIE29_RS13805	COG5002	protein histidine kinase activity
DIE29_RS13805	COG3447	MASE1 domain protein
DIE29_RS13810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DIE29_RS13825	COG0617	tRNA 3'-terminal CCA addition
DIE29_RS13850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DIE29_RS13855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DIE29_RS13890	COG0604	alcohol dehydrogenase
DIE29_RS13895	COG1309	transcriptional regulator
DIE29_RS13910	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DIE29_RS13960	COG2099	Precorrin-6x reductase
DIE29_RS13975	COG2875	Belongs to the precorrin methyltransferase family
DIE29_RS14015	COG0625	glutathione transferase activity
DIE29_RS14025	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DIE29_RS14030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DIE29_RS14035	COG2233	PERMEase
DIE29_RS14040	COG3300	MHYT domain
DIE29_RS14040	COG5001	Diguanylate cyclase
DIE29_RS14045	COG0708	Exodeoxyribonuclease III
DIE29_RS14050	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DIE29_RS14060	COG0243	molybdopterin cofactor binding
DIE29_RS14075	COG0251	oxidation-reduction process
DIE29_RS14085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DIE29_RS14115	COG0559	Belongs to the binding-protein-dependent transport system permease family
DIE29_RS14130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIE29_RS14135	COG4597	amino acid ABC transporter
DIE29_RS14140	COG0765	amino acid transport
DIE29_RS14145	COG1126	abc transporter atp-binding protein
DIE29_RS14155	COG3876	Protein conserved in bacteria
DIE29_RS14160	COG0659	secondary active sulfate transmembrane transporter activity
DIE29_RS14165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DIE29_RS14170	COG0583	DNA-binding transcription factor activity
DIE29_RS14175	COG2814	Major facilitator Superfamily
DIE29_RS14195	COG1857	crispr-associated protein
DIE29_RS14215	COG1518	maintenance of DNA repeat elements
DIE29_RS14220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DIE29_RS14250	COG2814	Major facilitator Superfamily
DIE29_RS14255	COG0606	chelatase, subunit chli
DIE29_RS14270	COG0347	Belongs to the P(II) protein family
DIE29_RS14275	COG0004	ammonium transporteR
DIE29_RS14290	COG0488	(ABC) transporter
DIE29_RS14315	COG0697	spore germination
DIE29_RS14325	COG0189	ligase activity
DIE29_RS14335	COG0732	type I restriction modification DNA specificity domain
DIE29_RS14335	COG0827	DNA restriction-modification system
DIE29_RS14345	COG0826	peptidase U32
DIE29_RS14350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DIE29_RS14355	COG3706	GGDEF domain
DIE29_RS14365	COG0488	(ABC) transporter
DIE29_RS14380	COG0306	phosphate transporter
DIE29_RS14385	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DIE29_RS14390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DIE29_RS14395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DIE29_RS14400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DIE29_RS14405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DIE29_RS14405	COG2813	Specifically methylates the guanine in position
DIE29_RS14425	COG0288	reversible hydration of carbon dioxide
DIE29_RS14430	COG1940	carbohydrate kinase activity
DIE29_RS14435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DIE29_RS14440	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DIE29_RS14445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DIE29_RS14450	COG0569	domain protein
DIE29_RS14455	COG2204	response regulator
DIE29_RS14460	COG5000	phosphorelay sensor kinase activity
DIE29_RS14470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DIE29_RS14470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DIE29_RS14475	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DIE29_RS14480	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DIE29_RS14490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DIE29_RS14495	COG0706	membrane insertase activity
DIE29_RS14500	COG0594	ribonuclease P activity
DIE29_RS14505	COG0230	Belongs to the bacterial ribosomal protein bL34 family