locus-tag	class	description
CCZ27_RS00005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CCZ27_RS00015	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CCZ27_RS00025	COG0352	thiamine-phosphate diphosphorylase activity
CCZ27_RS00030	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CCZ27_RS00035	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CCZ27_RS00040	COG0237	dephospho-CoA kinase activity
CCZ27_RS00050	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CCZ27_RS00055	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CCZ27_RS00060	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CCZ27_RS00060	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CCZ27_RS00070	COG3852	Histidine kinase
CCZ27_RS00080	COG0174	glutamine synthetase
CCZ27_RS00085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CCZ27_RS00100	COG3568	Endonuclease Exonuclease Phosphatase
CCZ27_RS00105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CCZ27_RS00110	COG1832	CoA-binding protein
CCZ27_RS00115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CCZ27_RS00125	COG0463	Glycosyl transferase, family 2
CCZ27_RS00165	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CCZ27_RS00190	COG4263	nitrous-oxide reductase activity
CCZ27_RS00200	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CCZ27_RS00245	COG0012	GTP binding
CCZ27_RS00255	COG0193	aminoacyl-tRNA hydrolase activity
CCZ27_RS00260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CCZ27_RS00265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CCZ27_RS00275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CCZ27_RS00280	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CCZ27_RS00290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CCZ27_RS00295	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CCZ27_RS00300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCZ27_RS00305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CCZ27_RS00310	COG0742	ribosomal rna small subunit methyltransferase
CCZ27_RS00315	COG0612	Peptidase, M16
CCZ27_RS00320	COG0612	Peptidase, M16
CCZ27_RS00330	COG2884	Cell division ATP-binding protein ftsE
CCZ27_RS00335	COG2177	Part of the ABC transporter FtsEX involved in
CCZ27_RS00355	COG1132	(ABC) transporter
CCZ27_RS00370	COG2259	Doxx family
CCZ27_RS00375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CCZ27_RS00400	COG2409	Drug exporters of the RND superfamily
CCZ27_RS00415	COG1012	belongs to the aldehyde dehydrogenase family
CCZ27_RS00450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CCZ27_RS00455	COG0242	peptide deformylase activity
CCZ27_RS00475	COG2271	Major facilitator Superfamily
CCZ27_RS00490	COG0179	Fumarylacetoacetate (FAA) hydrolase
CCZ27_RS00495	COG1451	nucleotide metabolic process
CCZ27_RS00505	COG2070	2-Nitropropane dioxygenase
CCZ27_RS00520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CCZ27_RS00525	COG2368	4-hydroxyphenylacetate
CCZ27_RS00565	COG0656	L-ascorbic acid biosynthetic process
CCZ27_RS00575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CCZ27_RS00580	COG1993	acr, cog1993
CCZ27_RS00605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CCZ27_RS00610	COG1702	phosphate starvation-inducible protein PhoH
CCZ27_RS00615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CCZ27_RS00620	COG4535	Mg2 and Co2 transporter CorC
CCZ27_RS00625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CCZ27_RS00635	COG1959	2 iron, 2 sulfur cluster binding
CCZ27_RS00640	COG0719	Fe-S assembly protein
CCZ27_RS00645	COG0396	ATPase activity
CCZ27_RS00650	COG0719	Fe-S assembly protein
CCZ27_RS00655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CCZ27_RS00670	COG0752	glycyl-tRNA synthetase alpha subunit
CCZ27_RS00680	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CCZ27_RS00685	COG0204	Acyl-transferase
CCZ27_RS00700	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CCZ27_RS00750	COG1459	type II secretion system
CCZ27_RS00755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CCZ27_RS00765	COG1127	ABC transporter
CCZ27_RS00770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CCZ27_RS00775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CCZ27_RS00795	COG1131	(ABC) transporter
CCZ27_RS00800	COG0842	Transport permease protein
CCZ27_RS00810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CCZ27_RS00820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CCZ27_RS00825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CCZ27_RS00830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CCZ27_RS00835	COG0131	Imidazoleglycerol-phosphate dehydratase
CCZ27_RS00840	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CCZ27_RS00845	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CCZ27_RS00850	COG0107	imidazoleglycerol-phosphate synthase activity
CCZ27_RS00855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CCZ27_RS00860	COG0140	phosphoribosyl-ATP diphosphatase activity
CCZ27_RS00870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CCZ27_RS00875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CCZ27_RS00885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CCZ27_RS00890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CCZ27_RS00905	COG0045	succinate-CoA ligase (ADP-forming) activity
CCZ27_RS00910	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CCZ27_RS00920	COG5212	phosphodiesterase
CCZ27_RS00925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CCZ27_RS00930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CCZ27_RS00935	COG0546	phosphoglycolate phosphatase activity
CCZ27_RS00960	COG0582	viral genome integration into host DNA
CCZ27_RS01040	COG2003	Belongs to the UPF0758 family
CCZ27_RS01195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CCZ27_RS01200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CCZ27_RS01225	COG1028	Short-chain dehydrogenase reductase Sdr
CCZ27_RS01240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CCZ27_RS01245	COG1024	Enoyl-CoA hydratase
CCZ27_RS01265	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CCZ27_RS01285	COG0583	DNA-binding transcription factor activity
CCZ27_RS01290	COG1396	sequence-specific DNA binding
CCZ27_RS01300	COG0512	Glutamine amidotransferase of anthranilate synthase
CCZ27_RS01305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CCZ27_RS01310	COG0134	indole-3-glycerol-phosphate synthase activity
CCZ27_RS01320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CCZ27_RS01425	COG1960	acyl-CoA dehydrogenase activity
CCZ27_RS01440	COG1012	belongs to the aldehyde dehydrogenase family
CCZ27_RS01465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CCZ27_RS01475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CCZ27_RS01480	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CCZ27_RS01515	COG0109	protoheme IX farnesyltransferase activity
CCZ27_RS01520	COG1999	signal sequence binding
CCZ27_RS01535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CCZ27_RS01545	COG0741	lytic transglycosylase activity
CCZ27_RS01550	COG0436	Aminotransferase
CCZ27_RS01555	COG0735	belongs to the Fur family
CCZ27_RS01570	COG1136	(ABC) transporter
CCZ27_RS01590	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CCZ27_RS01595	COG0280	phosphate acetyltransferase
CCZ27_RS01595	COG0281	malic enzyme
CCZ27_RS01615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CCZ27_RS01615	COG2111	Na H antiporter
CCZ27_RS01620	COG1006	Multisubunit Na H antiporter MnhC subunit
CCZ27_RS01625	COG0651	ATP synthesis coupled electron transport
CCZ27_RS01645	COG1187	pseudouridine synthase activity
CCZ27_RS01665	COG0577	efflux transmembrane transporter activity
CCZ27_RS01665	COG1136	(ABC) transporter
CCZ27_RS01670	COG0577	efflux transmembrane transporter activity
CCZ27_RS01670	COG1136	(ABC) transporter
CCZ27_RS01675	COG1566	PFAM secretion protein HlyD family protein
CCZ27_RS01680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CCZ27_RS01685	COG2885	chlorophyll binding
CCZ27_RS01690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CCZ27_RS01695	COG0145	ligase activity
CCZ27_RS01700	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CCZ27_RS01705	COG4647	ligase activity
CCZ27_RS01710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CCZ27_RS01730	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CCZ27_RS01735	COG0351	phosphomethylpyrimidine kinase
CCZ27_RS01740	COG3338	carbonate dehydratase activity
CCZ27_RS01755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CCZ27_RS01765	COG1538	Outer membrane efflux protein
CCZ27_RS01790	COG3744	PilT protein domain protein
CCZ27_RS01810	COG1131	(ABC) transporter
CCZ27_RS01830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CCZ27_RS01835	COG4636	protein conserved in cyanobacteria
CCZ27_RS01850	COG0537	adenosine 5'-monophosphoramidase activity
CCZ27_RS01855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCZ27_RS01870	COG2264	protein methyltransferase activity
CCZ27_RS01875	COG0439	Biotin carboxylase
CCZ27_RS01880	COG0511	ligase activity, forming carbon-carbon bonds
CCZ27_RS01885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CCZ27_RS01895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CCZ27_RS01905	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CCZ27_RS01910	COG0792	nuclease activity
CCZ27_RS01920	COG0418	dihydroorotase activity
CCZ27_RS01935	COG2001	Belongs to the MraZ family
CCZ27_RS01940	COG0275	rRNA processing
CCZ27_RS01945	COG3116	cell division
CCZ27_RS01955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CCZ27_RS01960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CCZ27_RS01965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CCZ27_RS01970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CCZ27_RS01975	COG0772	Belongs to the SEDS family
CCZ27_RS01980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CCZ27_RS01985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CCZ27_RS01990	COG1181	Belongs to the D-alanine--D-alanine ligase family
CCZ27_RS01995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CCZ27_RS02005	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CCZ27_RS02010	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CCZ27_RS02025	COG0653	protein targeting
CCZ27_RS02065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CCZ27_RS02070	COG2967	ApaG domain
CCZ27_RS02085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CCZ27_RS02090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CCZ27_RS02095	COG1862	Preprotein translocase
CCZ27_RS02100	COG0343	queuine tRNA-ribosyltransferase activity
CCZ27_RS02105	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CCZ27_RS02115	COG0583	DNA-binding transcription factor activity
CCZ27_RS02125	COG0670	Belongs to the BI1 family
CCZ27_RS02130	COG1320	monovalent cation:proton antiporter activity
CCZ27_RS02135	COG2212	antiporter activity
CCZ27_RS02140	COG1863	multisubunit Na H antiporter MnhE subunit
CCZ27_RS02145	COG0651	ATP synthesis coupled electron transport
CCZ27_RS02150	COG1006	Multisubunit Na H antiporter MnhC subunit
CCZ27_RS02155	COG2111	Na H antiporter
CCZ27_RS02155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CCZ27_RS02160	COG1253	flavin adenine dinucleotide binding
CCZ27_RS02165	COG0825	malonyl-CoA metabolic process
CCZ27_RS02170	COG0037	tRNA processing
CCZ27_RS02175	COG4566	intracellular signal transduction
CCZ27_RS02200	COG0586	Pfam SNARE associated Golgi protein
CCZ27_RS02205	COG0105	UTP biosynthetic process
CCZ27_RS02210	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CCZ27_RS02220	COG1426	Protein conserved in bacteria
CCZ27_RS02225	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CCZ27_RS02230	COG0124	histidyl-tRNA synthetase
CCZ27_RS02245	COG1160	GTP binding
CCZ27_RS02250	COG1923	regulation of RNA biosynthetic process
CCZ27_RS02255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CCZ27_RS02260	COG0330	HflC and HflK could
CCZ27_RS02265	COG0330	HflC and HflK could
CCZ27_RS02275	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CCZ27_RS02280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CCZ27_RS02295	COG0557	exoribonuclease II activity
CCZ27_RS02300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CCZ27_RS02305	COG3707	response regulator
CCZ27_RS02310	COG1116	anion transmembrane transporter activity
CCZ27_RS02315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CCZ27_RS02325	COG2223	nitrite transmembrane transporter activity
CCZ27_RS02335	COG0243	molybdopterin cofactor binding
CCZ27_RS02355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CCZ27_RS02360	COG0753	catalase activity
CCZ27_RS02365	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CCZ27_RS02370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CCZ27_RS02375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CCZ27_RS02380	COG0723	plastoquinol--plastocyanin reductase activity
CCZ27_RS02385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CCZ27_RS02390	COG2857	Cytochrome c1
CCZ27_RS02395	COG0625	glutathione transferase activity
CCZ27_RS02400	COG2969	positive regulation of protein catabolic process
CCZ27_RS02405	COG2703	oxygen carrier activity
CCZ27_RS02410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CCZ27_RS02415	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CCZ27_RS02440	COG0656	L-ascorbic acid biosynthetic process
CCZ27_RS02450	COG1067	ATP-dependent peptidase activity
CCZ27_RS02460	COG2954	triphosphatase activity
CCZ27_RS02470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CCZ27_RS02475	COG0459	protein refolding
CCZ27_RS02485	COG0642	Histidine kinase
CCZ27_RS02490	COG3162	membrane
CCZ27_RS02530	COG1160	GTP binding
CCZ27_RS02650	COG0582	viral genome integration into host DNA
CCZ27_RS02695	COG0582	viral genome integration into host DNA
CCZ27_RS02700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CCZ27_RS02705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CCZ27_RS02710	COG2890	protein-(glutamine-N5) methyltransferase activity
CCZ27_RS02715	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CCZ27_RS02740	COG2815	serine threonine protein kinase
CCZ27_RS02740	COG0515	serine threonine protein kinase
CCZ27_RS02745	COG0165	Argininosuccinate lyase
CCZ27_RS02750	COG3275	phosphorelay sensor kinase activity
CCZ27_RS02760	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CCZ27_RS02765	COG0181	hydroxymethylbilane synthase activity
CCZ27_RS02775	COG2959	enzyme of heme biosynthesis
CCZ27_RS02785	COG0408	coproporphyrinogen oxidase activity
CCZ27_RS02790	COG0151	Belongs to the GarS family
CCZ27_RS02795	COG0138	bifunctional purine biosynthesis protein purh
CCZ27_RS02800	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CCZ27_RS02815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CCZ27_RS02820	COG2011	ABC-type metal ion transport system permease component
CCZ27_RS02830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CCZ27_RS02835	COG0006	proline dipeptidase activity
CCZ27_RS02850	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CCZ27_RS02860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CCZ27_RS02865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CCZ27_RS02870	COG0071	Belongs to the small heat shock protein (HSP20) family
CCZ27_RS02885	COG2204	response regulator
CCZ27_RS02890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CCZ27_RS02935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CCZ27_RS02955	COG0346	lactoylglutathione lyase activity
CCZ27_RS02990	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CCZ27_RS02995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CCZ27_RS03000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CCZ27_RS03015	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CCZ27_RS03020	COG4974	Belongs to the 'phage' integrase family
CCZ27_RS03030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CCZ27_RS03035	COG1466	dna polymerase III delta subunit
CCZ27_RS03045	COG0495	leucyl-tRNA aminoacylation
CCZ27_RS03055	COG0210	DNA helicase
CCZ27_RS03060	COG1192	Involved in chromosome partitioning
CCZ27_RS03065	COG0281	malic enzyme
CCZ27_RS03065	COG0280	phosphate acetyltransferase
CCZ27_RS03085	COG1254	Belongs to the acylphosphatase family
CCZ27_RS03090	COG0659	secondary active sulfate transmembrane transporter activity
CCZ27_RS03095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CCZ27_RS03095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CCZ27_RS03110	COG0489	protein tyrosine kinase activity
CCZ27_RS03115	COG0717	Belongs to the dCTP deaminase family
CCZ27_RS03130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CCZ27_RS03160	COG2030	dehydratase
CCZ27_RS03165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CCZ27_RS03170	COG4191	Histidine kinase
CCZ27_RS03175	COG2204	response regulator
CCZ27_RS03190	COG0739	heme binding
CCZ27_RS03190	COG0741	lytic transglycosylase activity
CCZ27_RS03190	COG1196	nuclear chromosome segregation
CCZ27_RS03245	COG2944	sequence-specific DNA binding
CCZ27_RS03250	COG0582	viral genome integration into host DNA
CCZ27_RS03275	COG1696	Membrane protein involved in D-alanine export
CCZ27_RS03285	COG0488	(ABC) transporter
CCZ27_RS03295	COG1704	LemA family
CCZ27_RS03305	COG0604	alcohol dehydrogenase
CCZ27_RS03315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CCZ27_RS03335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CCZ27_RS03365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CCZ27_RS03370	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CCZ27_RS03375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CCZ27_RS03380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CCZ27_RS03385	COG0277	FAD linked oxidase domain protein
CCZ27_RS03395	COG0277	FAD linked oxidase domain protein
CCZ27_RS03400	COG0247	lactate metabolic process
CCZ27_RS03405	COG0631	protein serine/threonine phosphatase activity
CCZ27_RS03415	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CCZ27_RS03430	COG2203	Gaf domain
CCZ27_RS03430	COG4251	negative regulation of phosphorylation
CCZ27_RS03430	COG3706	GGDEF domain
CCZ27_RS03430	COG5001	Diguanylate cyclase
CCZ27_RS03440	COG0513	Belongs to the DEAD box helicase family
CCZ27_RS03445	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CCZ27_RS03450	COG0667	Aldo Keto reductase
CCZ27_RS03460	COG1653	transport
CCZ27_RS03465	COG0142	geranyltranstransferase activity
CCZ27_RS03475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CCZ27_RS03490	COG1271	oxidase subunit
CCZ27_RS03495	COG1294	oxidase, subunit
CCZ27_RS03510	COG0019	diaminopimelate decarboxylase activity
CCZ27_RS03540	COG4772	TonB-dependent receptor
CCZ27_RS03565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CCZ27_RS03580	COG4174	ABC transporter (Permease)
CCZ27_RS03585	COG4239	(ABC) transporter, permease
CCZ27_RS03590	COG4172	Belongs to the ABC transporter superfamily
CCZ27_RS03595	COG4166	transmembrane transport
CCZ27_RS03600	COG1132	(ABC) transporter
CCZ27_RS03630	COG4771	TonB-dependent receptor
CCZ27_RS03635	COG1132	(ABC) transporter
CCZ27_RS03640	COG1132	(ABC) transporter
CCZ27_RS03650	COG3829	transcription factor binding
CCZ27_RS03655	COG0431	NADPH-dependent FMN reductase
CCZ27_RS03665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CCZ27_RS03670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CCZ27_RS03685	COG2274	protein secretion by the type I secretion system
CCZ27_RS03690	COG1132	(ABC) transporter
CCZ27_RS03695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CCZ27_RS03700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CCZ27_RS03715	COG0315	cyclic pyranopterin monophosphate synthase activity
CCZ27_RS03725	COG0425	Belongs to the sulfur carrier protein TusA family
CCZ27_RS03745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CCZ27_RS03750	COG0795	lipopolysaccharide-transporting ATPase activity
CCZ27_RS03760	COG0335	large ribosomal subunit rRNA binding
CCZ27_RS03765	COG0336	Belongs to the RNA methyltransferase TrmD family
CCZ27_RS03770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CCZ27_RS03775	COG0228	four-way junction DNA binding
CCZ27_RS03785	COG1295	ribonuclease BN
CCZ27_RS03800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CCZ27_RS03805	COG1183	phosphatidylcholine synthase activity
CCZ27_RS03810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CCZ27_RS03815	COG0440	acetolactate synthase activity
CCZ27_RS03820	COG0028	Belongs to the TPP enzyme family
CCZ27_RS03840	COG0308	aminopeptidase N
CCZ27_RS03860	COG0516	GMP reductase activity
CCZ27_RS03860	COG0517	IMP dehydrogenase activity
CCZ27_RS03865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CCZ27_RS03870	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CCZ27_RS03875	COG1428	Deoxynucleoside kinase
CCZ27_RS03890	COG0617	tRNA 3'-terminal CCA addition
CCZ27_RS03905	COG0628	permease
CCZ27_RS03910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CCZ27_RS03930	COG1794	racemase activity, acting on amino acids and derivatives
CCZ27_RS03945	COG2824	Alkylphosphonate utilization operon protein PhnA
CCZ27_RS03955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ27_RS03960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCZ27_RS03975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CCZ27_RS03985	COG1960	acyl-CoA dehydrogenase activity
CCZ27_RS03995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CCZ27_RS04005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CCZ27_RS04015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CCZ27_RS04015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CCZ27_RS04020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CCZ27_RS04025	COG3264	Mechanosensitive ion channel
CCZ27_RS04025	COG1511	domain protein
CCZ27_RS04035	COG0720	synthase
CCZ27_RS04050	COG0527	aspartate kinase activity
CCZ27_RS04060	COG0252	asparaginase activity
CCZ27_RS04075	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CCZ27_RS04100	COG0564	pseudouridine synthase activity
CCZ27_RS04115	COG3243	poly(R)-hydroxyalkanoic acid synthase
CCZ27_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
CCZ27_RS04135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CCZ27_RS04140	COG1752	Esterase of the alpha-beta hydrolase superfamily
CCZ27_RS04145	COG0277	FAD linked oxidase domain protein
CCZ27_RS04195	COG3251	PFAM MbtH domain protein
CCZ27_RS04210	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CCZ27_RS04240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CCZ27_RS04255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ27_RS04305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CCZ27_RS04310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCZ27_RS04320	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CCZ27_RS04325	COG1250	3-hydroxyacyl-CoA dehydrogenase
CCZ27_RS04330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CCZ27_RS04340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CCZ27_RS04345	COG0517	IMP dehydrogenase activity
CCZ27_RS04345	COG0617	tRNA 3'-terminal CCA addition
CCZ27_RS04345	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CCZ27_RS04350	COG0318	PFAM AMP-dependent synthetase and ligase
CCZ27_RS04355	COG0028	Belongs to the TPP enzyme family
CCZ27_RS04360	COG0440	acetolactate synthase activity
CCZ27_RS04365	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CCZ27_RS04370	COG2814	Major facilitator Superfamily
CCZ27_RS04375	COG0501	Belongs to the peptidase M48B family
CCZ27_RS04380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CCZ27_RS04390	COG0066	3-isopropylmalate dehydratase activity
CCZ27_RS04395	COG0473	3-isopropylmalate dehydrogenase activity
CCZ27_RS04410	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CCZ27_RS04415	COG0101	tRNA pseudouridine synthase activity
CCZ27_RS04420	COG0135	phosphoribosylanthranilate isomerase activity
CCZ27_RS04425	COG0133	tryptophan synthase activity
CCZ27_RS04430	COG0159	tryptophan synthase activity
CCZ27_RS04435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CCZ27_RS04440	COG0285	dihydrofolate synthase activity
CCZ27_RS04475	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CCZ27_RS04480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CCZ27_RS04485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CCZ27_RS04490	COG0215	cysteine-tRNA ligase activity
CCZ27_RS04495	COG0484	heat shock protein binding
CCZ27_RS04500	COG0443	Heat shock 70 kDa protein
CCZ27_RS04505	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CCZ27_RS04565	COG2910	NAD(P)H-binding
CCZ27_RS04570	COG1764	response to oxidative stress
CCZ27_RS04580	COG1733	regulation of RNA biosynthetic process
CCZ27_RS04585	COG1802	Transcriptional regulator
CCZ27_RS04600	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CCZ27_RS04620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CCZ27_RS04620	COG0047	phosphoribosylformylglycinamidine synthase activity
CCZ27_RS04645	COG1012	belongs to the aldehyde dehydrogenase family
CCZ27_RS04655	COG3284	Transcriptional regulator
CCZ27_RS04660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CCZ27_RS04665	COG3550	peptidyl-serine autophosphorylation
CCZ27_RS04690	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CCZ27_RS04690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CCZ27_RS04695	COG2354	Protein conserved in bacteria
CCZ27_RS04705	COG0750	zinc metalloprotease
CCZ27_RS04730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CCZ27_RS04735	COG0287	Prephenate dehydrogenase
CCZ27_RS04740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CCZ27_RS04750	COG0776	regulation of translation
CCZ27_RS04760	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CCZ27_RS04795	COG2261	transglycosylase associated protein
CCZ27_RS04805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CCZ27_RS04810	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CCZ27_RS04815	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CCZ27_RS04820	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CCZ27_RS04825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CCZ27_RS04830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CCZ27_RS04830	COG0072	phenylalanine-tRNA ligase activity
CCZ27_RS04835	COG0776	regulation of translation
CCZ27_RS04840	COG0789	Transcriptional regulator
CCZ27_RS04855	COG3591	Belongs to the peptidase S1B family
CCZ27_RS04855	COG1864	DNA RNA non-specific endonuclease
CCZ27_RS04880	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CCZ27_RS04885	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CCZ27_RS04895	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CCZ27_RS04900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CCZ27_RS04920	COG2951	lytic endotransglycosylase activity
CCZ27_RS04935	COG0714	Associated with various cellular activities
CCZ27_RS04940	COG0123	including yeast histone deacetylase and acetoin utilization protein
CCZ27_RS04945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CCZ27_RS04950	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CCZ27_RS04965	COG2850	peptidyl-arginine hydroxylation
CCZ27_RS04970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CCZ27_RS04980	COG0156	8-amino-7-oxononanoate synthase activity
CCZ27_RS04985	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CCZ27_RS04990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CCZ27_RS05055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CCZ27_RS05085	COG4456	Virulence-associated protein
CCZ27_RS05110	COG1815	bacterial-type flagellum-dependent cell motility
CCZ27_RS05115	COG1558	bacterial-type flagellum-dependent cell motility
CCZ27_RS05125	COG1749	Flagellar hook protein flgE
CCZ27_RS05130	COG4787	bacterial-type flagellum-dependent cell motility
CCZ27_RS05140	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CCZ27_RS05145	COG1706	bacterial-type flagellum-dependent cell motility
CCZ27_RS05150	COG3951	Flagellar rod assembly protein muramidase FlgJ
CCZ27_RS05150	COG1705	Flagellar rod assembly protein muramidase FlgJ
CCZ27_RS05160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CCZ27_RS05190	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CCZ27_RS05215	COG1157	protein secretion by the type III secretion system
CCZ27_RS05230	COG1766	The M ring may be actively involved in energy transduction
CCZ27_RS05245	COG1677	Flagellar hook-basal body complex protein FliE
CCZ27_RS05255	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CCZ27_RS05260	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CCZ27_RS05285	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CCZ27_RS05295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CCZ27_RS05310	COG0562	UDP-galactopyranose mutase
CCZ27_RS05330	COG4608	Belongs to the ABC transporter superfamily
CCZ27_RS05335	COG0444	Belongs to the ABC transporter superfamily
CCZ27_RS05345	COG0601	transmembrane transport
CCZ27_RS05370	COG0747	negative chemotaxis
CCZ27_RS05375	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CCZ27_RS05395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CCZ27_RS05400	COG1045	serine acetyltransferase
CCZ27_RS05410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CCZ27_RS05415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CCZ27_RS05475	COG4691	Plasmid stability protein
CCZ27_RS05520	COG3739	integral membrane protein
CCZ27_RS05530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CCZ27_RS05535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CCZ27_RS05540	COG1116	anion transmembrane transporter activity
CCZ27_RS05550	COG0431	NADPH-dependent FMN reductase
CCZ27_RS05560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CCZ27_RS05605	COG1518	maintenance of DNA repeat elements
CCZ27_RS05610	COG0765	amino acid transport
CCZ27_RS05615	COG0765	amino acid transport
CCZ27_RS05620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCZ27_RS05625	COG3209	COG3209 Rhs family protein
CCZ27_RS05650	COG3209	COG3209 Rhs family protein
CCZ27_RS05660	COG3209	COG3209 Rhs family protein
CCZ27_RS05675	COG3209	COG3209 Rhs family protein
CCZ27_RS05680	COG3209	COG3209 Rhs family protein
CCZ27_RS05685	COG3209	COG3209 Rhs family protein
CCZ27_RS05695	COG4941	Belongs to the sigma-70 factor family
CCZ27_RS05710	COG3795	YCII-related domain
CCZ27_RS05725	COG2200	EAL domain
CCZ27_RS05730	COG0475	glutathione-regulated potassium exporter activity
CCZ27_RS05740	COG0469	pyruvate kinase activity
CCZ27_RS05755	COG1966	Carbon starvation protein
CCZ27_RS05765	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CCZ27_RS05770	COG2116	formate transmembrane transporter activity
CCZ27_RS05775	COG3275	phosphorelay sensor kinase activity
CCZ27_RS05780	COG3279	Response regulator of the LytR AlgR family
CCZ27_RS05790	COG0471	metal ion transport
CCZ27_RS05800	COG2391	methyltransferase activity
CCZ27_RS05805	COG2897	thiosulfate sulfurtransferase activity
CCZ27_RS05815	COG1116	anion transmembrane transporter activity
CCZ27_RS05820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CCZ27_RS05825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CCZ27_RS05830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CCZ27_RS05835	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CCZ27_RS05840	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CCZ27_RS05845	COG4208	sulfate ABC transporter
CCZ27_RS05850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CCZ27_RS05855	COG0583	DNA-binding transcription factor activity
CCZ27_RS05885	COG2197	response regulator
CCZ27_RS05915	COG2032	superoxide dismutase activity
CCZ27_RS05925	COG3209	COG3209 Rhs family protein
CCZ27_RS05960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CCZ27_RS05970	COG0504	CTP synthase activity
CCZ27_RS05975	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CCZ27_RS05980	COG0148	phosphopyruvate hydratase activity
CCZ27_RS05985	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CCZ27_RS05995	COG0791	NLP P60 protein
CCZ27_RS06015	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CCZ27_RS06025	COG0306	phosphate transporter
CCZ27_RS06035	COG0302	gtp cyclohydrolase
CCZ27_RS06045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CCZ27_RS06060	COG4681	YaeQ
CCZ27_RS06075	COG0513	Belongs to the DEAD box helicase family
CCZ27_RS06080	COG1278	Cold shock
CCZ27_RS06085	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CCZ27_RS06105	COG0613	PHP domain protein
CCZ27_RS06110	COG0009	L-threonylcarbamoyladenylate synthase
CCZ27_RS06115	COG1994	Peptidase M50
CCZ27_RS06120	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CCZ27_RS06125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CCZ27_RS06130	COG1187	pseudouridine synthase activity
CCZ27_RS06135	COG0779	Required for maturation of 30S ribosomal subunits
CCZ27_RS06140	COG2251	uridine kinase activity
CCZ27_RS06140	COG0195	Participates in both transcription termination and antitermination
CCZ27_RS06145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CCZ27_RS06150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CCZ27_RS06155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CCZ27_RS06160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CCZ27_RS06165	COG1185	polyribonucleotide nucleotidyltransferase activity
CCZ27_RS06170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CCZ27_RS06210	COG2081	HI0933 family
CCZ27_RS06220	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CCZ27_RS06235	COG0587	DNA-directed DNA polymerase activity
CCZ27_RS06245	COG1136	(ABC) transporter
CCZ27_RS06270	COG1162	GTPase activity
CCZ27_RS06275	COG0501	Belongs to the peptidase M48B family
CCZ27_RS06280	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CCZ27_RS06290	COG0254	rRNA binding
CCZ27_RS06305	COG3012	SEC-C Motif Domain Protein
CCZ27_RS06305	COG3318	Belongs to the UPF0149 family
CCZ27_RS06325	COG2501	S4 domain
CCZ27_RS06345	COG3012	SEC-C Motif Domain Protein
CCZ27_RS06395	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CCZ27_RS06400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CCZ27_RS06410	COG2814	Major facilitator Superfamily
CCZ27_RS06420	COG0039	L-malate dehydrogenase activity
CCZ27_RS06440	COG1053	succinate dehydrogenase
CCZ27_RS06445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CCZ27_RS06450	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CCZ27_RS06455	COG0372	Belongs to the citrate synthase family
CCZ27_RS06460	COG0567	Dehydrogenase, E1 component
CCZ27_RS06465	COG0508	dehydrogenase complex catalyzes the overall conversion of
CCZ27_RS06470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCZ27_RS06475	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CCZ27_RS06480	COG1199	ATP-dependent helicase activity
CCZ27_RS06485	COG1763	Mo-molybdopterin cofactor biosynthetic process
CCZ27_RS06490	COG0303	'Molybdopterin
CCZ27_RS06495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CCZ27_RS06500	COG0314	molybdopterin synthase activity
CCZ27_RS06520	COG1704	LemA family
CCZ27_RS06530	COG0488	(ABC) transporter
CCZ27_RS06540	COG0583	DNA-binding transcription factor activity
CCZ27_RS06550	COG1595	DNA-templated transcription, initiation
CCZ27_RS06555	COG3712	iron ion homeostasis
CCZ27_RS06560	COG4774	siderophore transport
CCZ27_RS06585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ27_RS06600	COG1595	DNA-templated transcription, initiation
CCZ27_RS06635	COG1027	Aspartate ammonia-lyase
CCZ27_RS06640	COG1301	dicarboxylic acid transport
CCZ27_RS06650	COG4191	Histidine kinase
CCZ27_RS06695	COG1648	precorrin-2 dehydrogenase activity
CCZ27_RS06695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CCZ27_RS06700	COG2010	Cytochrome c
CCZ27_RS06725	COG3391	amine dehydrogenase activity
CCZ27_RS06730	COG1522	sequence-specific DNA binding
CCZ27_RS06780	COG0535	radical SAM domain protein
CCZ27_RS06820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CCZ27_RS06850	COG2010	Cytochrome c
CCZ27_RS06865	COG0463	Glycosyl transferase, family 2
CCZ27_RS06890	COG0840	transmembrane signaling receptor activity
CCZ27_RS06895	COG0402	S-adenosylhomocysteine deaminase activity
CCZ27_RS06905	COG0167	dihydroorotate dehydrogenase activity
CCZ27_RS06910	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CCZ27_RS06915	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CCZ27_RS06920	COG3842	ATPase activity
CCZ27_RS06925	COG1178	ABC-type Fe3 transport system permease component
CCZ27_RS06935	COG1840	ABC-type Fe3 transport system, periplasmic component
CCZ27_RS06945	COG0791	NLP P60 protein
CCZ27_RS06960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CCZ27_RS06965	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CCZ27_RS06975	COG0436	Aminotransferase
CCZ27_RS06990	COG2258	MOSC domain
CCZ27_RS07005	COG3360	Dodecin
CCZ27_RS07020	COG1139	Iron-sulfur cluster binding protein
CCZ27_RS07030	COG0247	lactate metabolic process
CCZ27_RS07070	COG1473	amidohydrolase
CCZ27_RS07075	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CCZ27_RS07095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CCZ27_RS07120	COG0686	Belongs to the AlaDH PNT family
CCZ27_RS07125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CCZ27_RS07130	COG1067	ATP-dependent peptidase activity
CCZ27_RS07150	COG0556	nucleotide-excision repair
CCZ27_RS07155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CCZ27_RS07160	COG1530	ribonuclease E activity
CCZ27_RS07170	COG0564	pseudouridine synthase activity
CCZ27_RS07180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CCZ27_RS07185	COG0424	maF-like protein
CCZ27_RS07190	COG1399	metal-binding, possibly nucleic acid-binding protein
CCZ27_RS07195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CCZ27_RS07200	COG0416	fatty acid biosynthetic process
CCZ27_RS07205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CCZ27_RS07210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CCZ27_RS07220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CCZ27_RS07225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CCZ27_RS07235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CCZ27_RS07260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CCZ27_RS07270	COG0481	GTPase activity
CCZ27_RS07275	COG0681	Belongs to the peptidase S26 family
CCZ27_RS07285	COG0571	ribonuclease III activity
CCZ27_RS07290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CCZ27_RS07295	COG1381	Involved in DNA repair and RecF pathway recombination
CCZ27_RS07300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CCZ27_RS07305	COG0736	holo-[acyl-carrier-protein] synthase activity
CCZ27_RS07315	COG1472	Belongs to the glycosyl hydrolase 3 family
CCZ27_RS07320	COG0322	excinuclease ABC activity
CCZ27_RS07330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CCZ27_RS07350	COG0058	SHG alpha-glucan phosphorylase activity
CCZ27_RS07355	COG0297	glycogen (starch) synthase activity
CCZ27_RS07360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CCZ27_RS07365	COG0033	Phosphoglucomutase
CCZ27_RS07375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CCZ27_RS07390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CCZ27_RS07410	COG1396	sequence-specific DNA binding
CCZ27_RS07410	COG3800	Transcriptional regulator
CCZ27_RS07435	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CCZ27_RS07460	COG3800	Transcriptional regulator
CCZ27_RS07460	COG1396	sequence-specific DNA binding
CCZ27_RS07470	COG1960	acyl-CoA dehydrogenase activity
CCZ27_RS07475	COG1024	Enoyl-CoA hydratase
CCZ27_RS07480	COG1024	Enoyl-CoA hydratase
CCZ27_RS07490	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CCZ27_RS07495	COG4977	sequence-specific DNA binding
CCZ27_RS07505	COG0583	DNA-binding transcription factor activity
CCZ27_RS07555	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CCZ27_RS07560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCZ27_RS07575	COG4206	TonB-dependent receptor
CCZ27_RS07610	COG4215	(ABC) transporter
CCZ27_RS07615	COG0765	amino acid transport
CCZ27_RS07630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CCZ27_RS07655	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CCZ27_RS07665	COG0850	regulation of cytokinetic process
CCZ27_RS07670	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CCZ27_RS07675	COG1393	Belongs to the ArsC family
CCZ27_RS07680	COG2183	response to ionizing radiation
CCZ27_RS07700	COG1042	CoA-binding domain protein
CCZ27_RS07700	COG0045	succinate-CoA ligase (ADP-forming) activity
CCZ27_RS07700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CCZ27_RS07705	COG4251	negative regulation of phosphorylation
CCZ27_RS07715	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CCZ27_RS07720	COG0709	Synthesizes selenophosphate from selenide and ATP
CCZ27_RS07730	COG4181	ATPase activity
CCZ27_RS07735	COG0560	Phosphoserine phosphatase
CCZ27_RS07740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CCZ27_RS07745	COG2818	Glycosylase
CCZ27_RS07750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CCZ27_RS07760	COG0826	peptidase U32
CCZ27_RS07770	COG2133	pyrroloquinoline quinone binding
CCZ27_RS07805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CCZ27_RS07810	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CCZ27_RS07920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CCZ27_RS07960	COG2814	Major facilitator Superfamily
CCZ27_RS08000	COG0657	acetylesterase activity
CCZ27_RS08005	COG3158	transport of potassium into the cell
CCZ27_RS08010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CCZ27_RS08025	COG2274	protein secretion by the type I secretion system
CCZ27_RS08045	COG1376	ErfK ybiS ycfS ynhG family protein
CCZ27_RS08070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CCZ27_RS08075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CCZ27_RS08090	COG0084	hydrolase, TatD family'
CCZ27_RS08100	COG0446	pyridine nucleotide-disulphide oxidoreductase
CCZ27_RS08110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CCZ27_RS08110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CCZ27_RS08115	COG2719	SpoVR family
CCZ27_RS08125	COG2766	serine protein kinase
CCZ27_RS08130	COG0544	peptidyl-prolyl cis-trans isomerase activity
CCZ27_RS08135	COG0740	serine-type endopeptidase activity
CCZ27_RS08140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CCZ27_RS08145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CCZ27_RS08270	COG3485	protocatechuate 3,4-dioxygenase
CCZ27_RS08275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CCZ27_RS08300	COG2030	dehydratase
CCZ27_RS08310	COG0534	Mate efflux family protein
CCZ27_RS08325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CCZ27_RS08350	COG0741	lytic transglycosylase activity
CCZ27_RS08350	COG1388	LysM domain
CCZ27_RS08355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CCZ27_RS08360	COG2226	methyltransferase
CCZ27_RS08365	COG0328	RNA-DNA hybrid ribonuclease activity
CCZ27_RS08380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CCZ27_RS08385	COG0483	inositol monophosphate 1-phosphatase activity
CCZ27_RS08395	COG1045	serine acetyltransferase
CCZ27_RS08405	COG1104	cysteine desulfurase activity
CCZ27_RS08410	COG1104	cysteine desulfurase activity
CCZ27_RS08415	COG0822	iron-sulfur transferase activity
CCZ27_RS08425	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CCZ27_RS08430	COG0443	Heat shock 70 kDa protein
CCZ27_RS08435	COG0633	Ferredoxin
CCZ27_RS08445	COG0386	Belongs to the glutathione peroxidase family
CCZ27_RS08450	COG0745	RESPONSE REGULATOR receiver
CCZ27_RS08460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CCZ27_RS08470	COG2171	N-acyltransferase activity
CCZ27_RS08480	COG1196	nuclear chromosome segregation
CCZ27_RS08490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CCZ27_RS08515	COG2862	Uncharacterized protein family, UPF0114
CCZ27_RS08520	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CCZ27_RS08530	COG0052	Belongs to the universal ribosomal protein uS2 family
CCZ27_RS08535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CCZ27_RS08540	COG0528	UMP kinase activity
CCZ27_RS08545	COG0233	cytoplasmic translational termination
CCZ27_RS08550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CCZ27_RS08555	COG0575	Belongs to the CDS family
CCZ27_RS08560	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CCZ27_RS08580	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CCZ27_RS08585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CCZ27_RS08590	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CCZ27_RS08595	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CCZ27_RS08600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CCZ27_RS08605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CCZ27_RS08610	COG3022	response to hydroperoxide
CCZ27_RS08615	COG2866	Carboxypeptidase
CCZ27_RS08620	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CCZ27_RS08635	COG0577	efflux transmembrane transporter activity
CCZ27_RS08635	COG1136	(ABC) transporter
CCZ27_RS08640	COG0577	efflux transmembrane transporter activity
CCZ27_RS08650	COG1091	dTDP-4-dehydrorhamnose reductase activity
CCZ27_RS08670	COG4974	Belongs to the 'phage' integrase family
CCZ27_RS08810	COG2086	electron transfer activity
CCZ27_RS08820	COG0583	DNA-binding transcription factor activity
CCZ27_RS08830	COG0302	gtp cyclohydrolase
CCZ27_RS08840	COG1024	Enoyl-CoA hydratase
CCZ27_RS08845	COG1960	acyl-CoA dehydrogenase activity
CCZ27_RS08850	COG1960	acyl-CoA dehydrogenase activity
CCZ27_RS08860	COG2124	cytochrome p450
CCZ27_RS08865	COG1028	Short-chain dehydrogenase reductase Sdr
CCZ27_RS08885	COG1028	Short-chain dehydrogenase reductase Sdr
CCZ27_RS08890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CCZ27_RS08920	COG1233	COG1233 Phytoene dehydrogenase and related
CCZ27_RS08940	COG0427	acetyl-CoA hydrolase
CCZ27_RS08945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CCZ27_RS09045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CCZ27_RS09050	COG1671	Belongs to the UPF0178 family
CCZ27_RS09130	COG3041	Addiction module toxin RelE StbE family
CCZ27_RS09135	COG3077	Addiction module antitoxin, RelB DinJ family
CCZ27_RS09200	COG3609	addiction module antidote protein, CC2985 family
CCZ27_RS09225	COG0837	glucose binding
CCZ27_RS09230	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CCZ27_RS09235	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CCZ27_RS09240	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CCZ27_RS09245	COG2205	protein histidine kinase activity
CCZ27_RS09250	COG0745	RESPONSE REGULATOR receiver
CCZ27_RS09255	COG1487	ribonuclease activity
CCZ27_RS09275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CCZ27_RS09285	COG1028	Short-chain dehydrogenase reductase Sdr
CCZ27_RS09305	COG0166	Belongs to the GPI family
CCZ27_RS09340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ27_RS09385	COG4221	oxidoreductase activity
CCZ27_RS09395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CCZ27_RS09435	COG4396	Host-nuclease inhibitor protein Gam
CCZ27_RS09670	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CCZ27_RS09675	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CCZ27_RS09680	COG4638	Rieske (2fe-2S)
CCZ27_RS09695	COG2076	Multidrug Resistance protein
CCZ27_RS09705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CCZ27_RS09720	COG2351	hydroxyisourate hydrolase activity
CCZ27_RS09740	COG4266	Belongs to the allantoicase family
CCZ27_RS09745	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CCZ27_RS09750	COG0842	Transport permease protein
CCZ27_RS09755	COG1131	(ABC) transporter
CCZ27_RS09785	COG0697	spore germination
CCZ27_RS09795	COG1301	dicarboxylic acid transport
CCZ27_RS09800	COG4266	Belongs to the allantoicase family
CCZ27_RS09805	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CCZ27_RS09815	COG2233	PERMEase
CCZ27_RS09835	COG0583	DNA-binding transcription factor activity
CCZ27_RS09845	COG1573	uracil-dna glycosylase
CCZ27_RS09885	COG2917	probably involved in intracellular septation
CCZ27_RS09890	COG2350	Protein conserved in bacteria
CCZ27_RS09900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CCZ27_RS09905	COG1960	acyl-CoA dehydrogenase activity
CCZ27_RS09925	COG1309	transcriptional regulator
CCZ27_RS09930	COG0084	hydrolase, TatD family'
CCZ27_RS09935	COG1024	Enoyl-CoA hydratase
CCZ27_RS09940	COG0318	PFAM AMP-dependent synthetase and ligase
CCZ27_RS09955	COG1127	ABC transporter
CCZ27_RS09960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CCZ27_RS09965	COG0248	Ppx GppA phosphatase
CCZ27_RS09970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CCZ27_RS09975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CCZ27_RS09980	COG3228	Belongs to the MtfA family
CCZ27_RS09995	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CCZ27_RS10000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CCZ27_RS10005	COG3174	membrane
CCZ27_RS10010	COG1355	regulation of microtubule-based process
CCZ27_RS10015	COG2078	PFAM AMMECR1 domain protein
CCZ27_RS10030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CCZ27_RS10035	COG0598	Magnesium transport protein CorA
CCZ27_RS10050	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CCZ27_RS10055	COG0802	atpase or kinase
CCZ27_RS10060	COG0860	N-Acetylmuramoyl-L-alanine amidase
CCZ27_RS10065	COG0196	riboflavin kinase activity
CCZ27_RS10070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CCZ27_RS10075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CCZ27_RS10080	COG1047	Peptidyl-prolyl cis-trans
CCZ27_RS10085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CCZ27_RS10095	COG1722	exodeoxyribonuclease VII activity
CCZ27_RS10100	COG0142	geranyltranstransferase activity
CCZ27_RS10105	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CCZ27_RS10110	COG1469	GTP cyclohydrolase I activity
CCZ27_RS10115	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CCZ27_RS10145	COG0366	Alpha amylase catalytic
CCZ27_RS10170	COG0484	heat shock protein binding
CCZ27_RS10175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CCZ27_RS10185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CCZ27_RS10190	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CCZ27_RS10195	COG1674	ftsk spoiiie
CCZ27_RS10205	COG0492	ferredoxin-NADP+ reductase activity
CCZ27_RS10210	COG2840	Smr protein MutS2
CCZ27_RS10220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CCZ27_RS10220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CCZ27_RS10235	COG1007	ATP synthesis coupled electron transport
CCZ27_RS10250	COG0713	ATP synthesis coupled electron transport
CCZ27_RS10260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CCZ27_RS10265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CCZ27_RS10270	COG1034	ATP synthesis coupled electron transport
CCZ27_RS10270	COG1034	ATP synthesis coupled electron transport
CCZ27_RS10280	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CCZ27_RS10285	COG0649	NAD binding
CCZ27_RS10290	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CCZ27_RS10295	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CCZ27_RS10300	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CCZ27_RS10315	COG0149	triose-phosphate isomerase activity
CCZ27_RS10320	COG0268	Binds directly to 16S ribosomal RNA
CCZ27_RS10335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CCZ27_RS10345	COG0573	inorganic phosphate transmembrane transporter activity
CCZ27_RS10365	COG3549	Plasmid maintenance system killer
CCZ27_RS10400	COG3621	Patatin-like phospholipase
CCZ27_RS10415	COG3328	transposase activity
CCZ27_RS10450	COG0464	growth
CCZ27_RS10505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CCZ27_RS10610	COG1201	RNA secondary structure unwinding
CCZ27_RS10690	COG2249	NAD(P)H dehydrogenase (quinone) activity
CCZ27_RS10750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CCZ27_RS10755	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CCZ27_RS10875	COG2003	Belongs to the UPF0758 family
CCZ27_RS10915	COG1192	Involved in chromosome partitioning
CCZ27_RS10950	COG0582	viral genome integration into host DNA
CCZ27_RS10955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CCZ27_RS10955	COG0519	Catalyzes the synthesis of GMP from XMP
CCZ27_RS10970	COG2914	Belongs to the UPF0125 (RnfH) family
CCZ27_RS10975	COG2867	negative regulation of translational initiation
CCZ27_RS10980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CCZ27_RS10985	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CCZ27_RS10990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCZ27_RS10995	COG0601	transmembrane transport
CCZ27_RS11010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CCZ27_RS11020	COG0542	response to heat
CCZ27_RS11025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CCZ27_RS11030	COG5002	protein histidine kinase activity
CCZ27_RS11030	COG2176	DNA-directed DNA polymerase activity
CCZ27_RS11035	COG0745	RESPONSE REGULATOR receiver
CCZ27_RS11040	COG5002	protein histidine kinase activity
CCZ27_RS11050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CCZ27_RS11070	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CCZ27_RS11080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CCZ27_RS11085	COG0183	Belongs to the thiolase family
CCZ27_RS11105	COG4969	Belongs to the N-Me-Phe pilin family
CCZ27_RS11115	COG4966	pilus assembly protein PilW
CCZ27_RS11135	COG1666	GTP binding
CCZ27_RS11140	COG3123	guanosine phosphorylase activity
CCZ27_RS11150	COG0137	argininosuccinate synthase activity
CCZ27_RS11155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CCZ27_RS11160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CCZ27_RS11175	COG0581	inorganic phosphate transmembrane transporter activity
CCZ27_RS11180	COG0573	inorganic phosphate transmembrane transporter activity
CCZ27_RS11185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CCZ27_RS11190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CCZ27_RS11195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CCZ27_RS11200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CCZ27_RS11205	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CCZ27_RS11210	COG1534	Rna-binding protein
CCZ27_RS11220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CCZ27_RS11225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CCZ27_RS11230	COG0505	Belongs to the CarA family
CCZ27_RS11235	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CCZ27_RS11240	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CCZ27_RS11245	COG0735	belongs to the Fur family
CCZ27_RS11250	COG0497	DNA recombination
CCZ27_RS11255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CCZ27_RS11260	COG1420	regulation of RNA biosynthetic process
CCZ27_RS11265	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CCZ27_RS11270	COG2815	serine threonine protein kinase
CCZ27_RS11270	COG0515	serine threonine protein kinase
CCZ27_RS11275	COG0402	S-adenosylhomocysteine deaminase activity
CCZ27_RS11285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CCZ27_RS11295	COG2951	lytic endotransglycosylase activity
CCZ27_RS11300	COG0438	transferase activity, transferring glycosyl groups
CCZ27_RS11315	COG0443	Heat shock 70 kDa protein
CCZ27_RS11345	COG1032	radical SAM domain protein
CCZ27_RS11350	COG2267	carboxylic ester hydrolase activity
CCZ27_RS11355	COG2226	methyltransferase
CCZ27_RS11365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CCZ27_RS11370	COG2766	serine protein kinase
CCZ27_RS11380	COG2719	SpoVR family
CCZ27_RS11430	COG0505	Belongs to the CarA family
CCZ27_RS11440	COG1196	nuclear chromosome segregation
CCZ27_RS11455	COG1518	maintenance of DNA repeat elements
CCZ27_RS11490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CCZ27_RS11505	COG1192	Involved in chromosome partitioning
CCZ27_RS11555	COG1459	type II secretion system
CCZ27_RS11565	COG0739	heme binding
CCZ27_RS11565	COG0741	lytic transglycosylase activity
CCZ27_RS11565	COG1196	nuclear chromosome segregation
CCZ27_RS11595	COG0811	peptide transport
CCZ27_RS11625	COG2771	luxR family
CCZ27_RS11695	COG0739	heme binding
CCZ27_RS11705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CCZ27_RS11730	COG0438	transferase activity, transferring glycosyl groups
CCZ27_RS11745	COG0438	transferase activity, transferring glycosyl groups
CCZ27_RS11785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CCZ27_RS11790	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CCZ27_RS11830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CCZ27_RS11865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCZ27_RS11865	COG0574	Belongs to the PEP-utilizing enzyme family
CCZ27_RS11870	COG3243	poly(R)-hydroxyalkanoic acid synthase
CCZ27_RS11885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CCZ27_RS11890	COG0469	pyruvate kinase activity
CCZ27_RS11895	COG0583	DNA-binding transcription factor activity
CCZ27_RS11900	COG1741	Belongs to the pirin family
CCZ27_RS11905	COG1335	isochorismatase
CCZ27_RS11915	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CCZ27_RS11930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CCZ27_RS11950	COG3668	Plasmid stabilization system
CCZ27_RS11970	COG0009	L-threonylcarbamoyladenylate synthase
CCZ27_RS11975	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CCZ27_RS11980	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CCZ27_RS11985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CCZ27_RS12000	COG4566	intracellular signal transduction
CCZ27_RS12010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CCZ27_RS12015	COG0508	dehydrogenase complex catalyzes the overall conversion of
CCZ27_RS12020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCZ27_RS12050	COG0509	glycine decarboxylation via glycine cleavage system
CCZ27_RS12055	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CCZ27_RS12055	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CCZ27_RS12070	COG1215	transferase activity, transferring glycosyl groups
CCZ27_RS12075	COG0405	Gamma-glutamyltransferase
CCZ27_RS12085	COG0563	adenylate kinase activity
CCZ27_RS12090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CCZ27_RS12095	COG2835	tetraacyldisaccharide 4'-kinase activity
CCZ27_RS12100	COG1663	tetraacyldisaccharide 4'-kinase activity
CCZ27_RS12105	COG0848	biopolymer transport protein
CCZ27_RS12110	COG0811	peptide transport
CCZ27_RS12115	COG1570	exodeoxyribonuclease VII activity
CCZ27_RS12120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CCZ27_RS12150	COG1690	Belongs to the RtcB family
CCZ27_RS12210	COG1196	nuclear chromosome segregation
CCZ27_RS12230	COG0443	Heat shock 70 kDa protein
CCZ27_RS12275	COG2135	peptidase activity
CCZ27_RS12310	COG1335	isochorismatase
CCZ27_RS12340	COG1902	pentaerythritol trinitrate reductase activity
CCZ27_RS12350	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CCZ27_RS12360	COG0564	pseudouridine synthase activity
CCZ27_RS12365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CCZ27_RS12370	COG0643	Histidine kinase
CCZ27_RS12370	COG0784	Response regulator, receiver
CCZ27_RS12370	COG2198	Histidine kinase
CCZ27_RS12375	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CCZ27_RS12380	COG0745	RESPONSE REGULATOR receiver
CCZ27_RS12385	COG0784	Response regulator, receiver
CCZ27_RS12385	COG0835	chemotaxis
CCZ27_RS12390	COG0784	Response regulator, receiver
CCZ27_RS12390	COG0835	chemotaxis
CCZ27_RS12395	COG1360	Flagellar Motor Protein
CCZ27_RS12400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CCZ27_RS12425	COG4657	Part of a membrane complex involved in electron transport
CCZ27_RS12430	COG2878	Part of a membrane complex involved in electron transport
CCZ27_RS12435	COG4656	Part of a membrane complex involved in electron transport
CCZ27_RS12445	COG4659	FMN binding
CCZ27_RS12455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CCZ27_RS12465	COG0121	glutamine amidotransferase
CCZ27_RS12470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CCZ27_RS12475	COG0626	cystathionine gamma-synthase activity
CCZ27_RS12485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CCZ27_RS12500	COG1846	Transcriptional regulator
CCZ27_RS12510	COG2070	2-Nitropropane dioxygenase
CCZ27_RS12555	COG2353	YceI-like domain
CCZ27_RS12560	COG0326	Molecular chaperone. Has ATPase activity
CCZ27_RS12590	COG1230	cation diffusion facilitator family transporter
CCZ27_RS12630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCZ27_RS12665	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CCZ27_RS12670	COG1858	cytochrome C peroxidase
CCZ27_RS12675	COG4771	TonB-dependent receptor
CCZ27_RS12680	COG3712	iron ion homeostasis
CCZ27_RS12685	COG1595	DNA-templated transcription, initiation
CCZ27_RS12695	COG2217	Heavy metal translocating P-type atpase
CCZ27_RS12710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CCZ27_RS12715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CCZ27_RS12740	COG1116	anion transmembrane transporter activity
CCZ27_RS12750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CCZ27_RS12755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CCZ27_RS12760	COG0431	NADPH-dependent FMN reductase
CCZ27_RS12765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CCZ27_RS12775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CCZ27_RS12790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CCZ27_RS12795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CCZ27_RS12835	COG0235	Class ii aldolase
CCZ27_RS12845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CCZ27_RS12875	COG2010	Cytochrome c
CCZ27_RS12890	COG3278	Belongs to the heme-copper respiratory oxidase family
CCZ27_RS12900	COG2217	Heavy metal translocating P-type atpase
CCZ27_RS12925	COG0583	DNA-binding transcription factor activity
CCZ27_RS12935	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CCZ27_RS12940	COG0697	spore germination
CCZ27_RS12955	COG1346	cytolysis
CCZ27_RS12995	COG0538	isocitrate dehydrogenase activity
CCZ27_RS13000	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CCZ27_RS13015	COG2863	cytochrome
CCZ27_RS13020	COG0446	pyridine nucleotide-disulphide oxidoreductase
CCZ27_RS13030	COG0756	dUTP diphosphatase activity
CCZ27_RS13035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CCZ27_RS13040	COG2003	Belongs to the UPF0758 family
CCZ27_RS13045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CCZ27_RS13050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CCZ27_RS13055	COG1278	Cold shock
CCZ27_RS13060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CCZ27_RS13065	COG0542	response to heat
CCZ27_RS13070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CCZ27_RS13095	COG0583	DNA-binding transcription factor activity
CCZ27_RS13110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CCZ27_RS13130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CCZ27_RS13135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CCZ27_RS13140	COG0739	heme binding
CCZ27_RS13145	COG0316	Belongs to the HesB IscA family
CCZ27_RS13150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CCZ27_RS13155	COG3284	Transcriptional regulator
CCZ27_RS13180	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
CCZ27_RS13185	COG1229	Formylmethanofuran dehydrogenase subunit A
CCZ27_RS13240	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
CCZ27_RS13245	COG0189	ligase activity
CCZ27_RS13250	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
CCZ27_RS13255	COG0702	epimerase
CCZ27_RS13270	COG2154	pterin-4-alpha-carbinolamine dehydratase
CCZ27_RS13355	COG1131	(ABC) transporter
CCZ27_RS13385	COG2197	response regulator
CCZ27_RS13390	COG0535	radical SAM domain protein
CCZ27_RS13400	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CCZ27_RS13405	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CCZ27_RS13420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CCZ27_RS13425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CCZ27_RS13430	COG1765	OsmC-like protein
CCZ27_RS13435	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CCZ27_RS13450	COG0247	lactate metabolic process
CCZ27_RS13465	COG0494	nUDIX hydrolase
CCZ27_RS13470	COG0442	prolyl-tRNA aminoacylation
CCZ27_RS13475	COG0741	lytic transglycosylase activity
CCZ27_RS13485	COG2205	protein histidine kinase activity
CCZ27_RS13495	COG2204	response regulator
CCZ27_RS13510	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CCZ27_RS13515	COG0312	modulator of DNA gyrase
CCZ27_RS13530	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CCZ27_RS13550	COG0482	sulfurtransferase activity
CCZ27_RS13580	COG0429	hydrolase of the alpha beta-hydrolase fold
CCZ27_RS13590	COG1607	acyl-coa hydrolase
CCZ27_RS13595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CCZ27_RS13600	COG2096	Adenosyltransferase
CCZ27_RS13615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CCZ27_RS13620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CCZ27_RS13640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CCZ27_RS13645	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CCZ27_RS13650	COG0521	Mo-molybdopterin cofactor biosynthetic process
CCZ27_RS13655	COG3028	Belongs to the UPF0307 family
CCZ27_RS13660	COG0312	modulator of DNA gyrase
CCZ27_RS13670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CCZ27_RS13675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CCZ27_RS13680	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CCZ27_RS13680	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CCZ27_RS13695	COG0793	Belongs to the peptidase S41A family
CCZ27_RS13710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CCZ27_RS13720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CCZ27_RS13730	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CCZ27_RS13735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CCZ27_RS13745	COG2226	methyltransferase
CCZ27_RS13775	COG2833	Protein of unknown function (DUF455)
CCZ27_RS13780	COG0303	'Molybdopterin
CCZ27_RS13785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CCZ27_RS13790	COG0704	Plays a role in the regulation of phosphate uptake
CCZ27_RS13795	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CCZ27_RS13805	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CCZ27_RS13805	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CCZ27_RS13815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CCZ27_RS13820	COG0483	inositol monophosphate 1-phosphatase activity
CCZ27_RS13825	COG3954	Phosphoribulokinase
CCZ27_RS13835	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CCZ27_RS13840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CCZ27_RS13845	COG0126	phosphoglycerate kinase activity
CCZ27_RS13880	COG4451	ribulose bisphosphate carboxylase, small
CCZ27_RS13890	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CCZ27_RS13895	COG3954	Phosphoribulokinase
CCZ27_RS13905	COG0126	phosphoglycerate kinase activity
CCZ27_RS13915	COG1301	dicarboxylic acid transport
CCZ27_RS13925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CCZ27_RS13930	COG2223	nitrite transmembrane transporter activity
CCZ27_RS13955	COG0730	response to heat
CCZ27_RS13965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CCZ27_RS13975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CCZ27_RS13985	COG2814	Major facilitator Superfamily
CCZ27_RS13995	COG0175	sulfate reduction
CCZ27_RS14005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CCZ27_RS14010	COG0318	PFAM AMP-dependent synthetase and ligase
CCZ27_RS14045	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CCZ27_RS14070	COG1216	Glycosyl transferase, family 2
CCZ27_RS14080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CCZ27_RS14100	COG0463	Glycosyl transferase, family 2
CCZ27_RS14115	COG1215	transferase activity, transferring glycosyl groups
CCZ27_RS14120	COG1215	transferase activity, transferring glycosyl groups
CCZ27_RS14125	COG3119	arylsulfatase activity
CCZ27_RS14130	COG0297	glycogen (starch) synthase activity
CCZ27_RS14140	COG0438	transferase activity, transferring glycosyl groups
CCZ27_RS14150	COG0297	glycogen (starch) synthase activity
CCZ27_RS14160	COG0367	asparagine synthase
CCZ27_RS14170	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CCZ27_RS14180	COG0438	transferase activity, transferring glycosyl groups
CCZ27_RS14200	COG0367	asparagine synthase
CCZ27_RS14205	COG0438	transferase activity, transferring glycosyl groups
CCZ27_RS14230	COG3267	Type II secretory pathway component ExeA
CCZ27_RS14230	COG3409	Peptidoglycan-binding domain 1 protein
CCZ27_RS14240	COG0489	protein tyrosine kinase activity
CCZ27_RS14265	COG0577	efflux transmembrane transporter activity
CCZ27_RS14265	COG1136	(ABC) transporter
CCZ27_RS14290	COG0436	Aminotransferase
CCZ27_RS14295	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CCZ27_RS14300	COG0235	Class ii aldolase
CCZ27_RS14310	COG2084	Dehydrogenase
CCZ27_RS14315	COG2084	Dehydrogenase
CCZ27_RS14320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CCZ27_RS14330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CCZ27_RS14340	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CCZ27_RS14365	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CCZ27_RS14370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CCZ27_RS14385	COG0629	single-stranded DNA binding
CCZ27_RS14390	COG2814	Major facilitator Superfamily
CCZ27_RS14400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CCZ27_RS14405	COG0203	ribosomal protein L17
CCZ27_RS14410	COG0202	RNA polymerase activity
CCZ27_RS14415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CCZ27_RS14420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CCZ27_RS14425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CCZ27_RS14430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CCZ27_RS14435	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CCZ27_RS14440	COG0201	protein transport
CCZ27_RS14445	COG0200	Binds to the 23S rRNA
CCZ27_RS14450	COG1841	ribosomal large subunit assembly
CCZ27_RS14455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CCZ27_RS14460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CCZ27_RS14465	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CCZ27_RS14470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CCZ27_RS14475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CCZ27_RS14480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CCZ27_RS14485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CCZ27_RS14490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CCZ27_RS14495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CCZ27_RS14500	COG0255	Belongs to the universal ribosomal protein uL29 family
CCZ27_RS14505	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CCZ27_RS14510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CCZ27_RS14515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CCZ27_RS14520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CCZ27_RS14525	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CCZ27_RS14530	COG0089	rRNA binding
CCZ27_RS14535	COG0088	Forms part of the polypeptide exit tunnel
CCZ27_RS14540	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CCZ27_RS14545	COG0051	transcription antitermination factor activity, RNA binding
CCZ27_RS14550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CCZ27_RS14555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CCZ27_RS14560	COG0049	tRNA binding
CCZ27_RS14565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CCZ27_RS14570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CCZ27_RS14575	COG0085	RNA polymerase activity
CCZ27_RS14580	COG0222	ribosome binding
CCZ27_RS14585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CCZ27_RS14590	COG0081	regulation of translation
CCZ27_RS14605	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CCZ27_RS14615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CCZ27_RS14635	COG0277	FAD linked oxidase domain protein
CCZ27_RS14655	COG2197	response regulator
CCZ27_RS14665	COG2205	protein histidine kinase activity
CCZ27_RS14665	COG0784	Response regulator, receiver
CCZ27_RS14665	COG2198	Histidine kinase
CCZ27_RS14675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CCZ27_RS14710	COG1022	Amp-dependent synthetase and ligase
CCZ27_RS14715	COG2267	carboxylic ester hydrolase activity
CCZ27_RS14745	COG3384	dioxygenase
CCZ27_RS14750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CCZ27_RS14755	COG1414	Transcriptional regulator
CCZ27_RS14765	COG3177	Filamentation induced by cAMP protein fic
CCZ27_RS14770	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CCZ27_RS14770	COG1703	isobutyryl-CoA mutase activity
CCZ27_RS14770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CCZ27_RS14780	COG0784	Response regulator, receiver
CCZ27_RS14780	COG4191	Histidine kinase
CCZ27_RS14795	COG2321	neutral zinc metallopeptidase
CCZ27_RS14800	COG4770	biotin carboxylase activity
CCZ27_RS14805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CCZ27_RS14810	COG1703	isobutyryl-CoA mutase activity
CCZ27_RS14815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CCZ27_RS14815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CCZ27_RS14820	COG1802	Transcriptional regulator
CCZ27_RS14825	COG1253	flavin adenine dinucleotide binding
CCZ27_RS14830	COG0114	fumarate hydratase activity
CCZ27_RS14835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CCZ27_RS14840	COG3162	membrane
CCZ27_RS14845	COG1024	Enoyl-CoA hydratase
CCZ27_RS14855	COG1121	(ABC) transporter
CCZ27_RS14860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CCZ27_RS14890	COG1858	cytochrome C peroxidase
CCZ27_RS14895	COG1858	cytochrome C peroxidase
CCZ27_RS14940	COG0129	dihydroxy-acid dehydratase activity
CCZ27_RS14945	COG3132	Protein of unknown function, DUF480
CCZ27_RS14950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CCZ27_RS14960	COG5001	Diguanylate cyclase
CCZ27_RS15005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ27_RS15010	COG1136	(ABC) transporter
CCZ27_RS15010	COG0577	efflux transmembrane transporter activity
CCZ27_RS15020	COG4774	siderophore transport
CCZ27_RS15030	COG3128	pkhd-type hydroxylase
CCZ27_RS15035	COG1858	cytochrome C peroxidase
CCZ27_RS15060	COG4771	TonB-dependent receptor
CCZ27_RS15080	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CCZ27_RS15155	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CCZ27_RS15200	COG5002	protein histidine kinase activity
CCZ27_RS15210	COG2274	protein secretion by the type I secretion system
CCZ27_RS15245	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCZ27_RS15260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CCZ27_RS15265	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CCZ27_RS15270	COG0443	Heat shock 70 kDa protein
CCZ27_RS15275	COG2816	NAD+ diphosphatase activity
CCZ27_RS15280	COG0589	response to stress
CCZ27_RS15320	COG3038	cytochrome b561
CCZ27_RS15330	COG0840	transmembrane signaling receptor activity
CCZ27_RS15340	COG1126	abc transporter atp-binding protein
CCZ27_RS15345	COG0765	amino acid transport
CCZ27_RS15355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CCZ27_RS15365	COG0583	DNA-binding transcription factor activity
CCZ27_RS15370	COG3960	tartronate-semialdehyde synthase activity
CCZ27_RS15375	COG3622	Belongs to the hyi family
CCZ27_RS15380	COG2084	Dehydrogenase
CCZ27_RS15400	COG0469	pyruvate kinase activity
CCZ27_RS15475	COG0583	DNA-binding transcription factor activity
CCZ27_RS15530	COG1846	Transcriptional regulator
CCZ27_RS15535	COG2814	Major facilitator Superfamily
CCZ27_RS15540	COG0583	DNA-binding transcription factor activity
CCZ27_RS15555	COG2814	Major facilitator Superfamily
CCZ27_RS15560	COG2860	membrane
CCZ27_RS15570	COG0861	Integral membrane protein TerC family
CCZ27_RS15585	COG1024	Enoyl-CoA hydratase
CCZ27_RS15590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CCZ27_RS15595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CCZ27_RS15595	COG0473	3-isopropylmalate dehydrogenase activity
CCZ27_RS15605	COG3384	dioxygenase
CCZ27_RS15610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CCZ27_RS15625	COG3181	Tripartite tricarboxylate transporter family receptor
CCZ27_RS15630	COG1960	acyl-CoA dehydrogenase activity
CCZ27_RS15635	COG1960	acyl-CoA dehydrogenase activity
CCZ27_RS15660	COG2159	amidohydrolase
CCZ27_RS15670	COG3181	Tripartite tricarboxylate transporter family receptor
CCZ27_RS15680	COG1024	Enoyl-CoA hydratase
CCZ27_RS15710	COG2814	Major facilitator Superfamily
CCZ27_RS15730	COG2226	methyltransferase
CCZ27_RS15750	COG0798	PFAM Bile acid sodium symporter
CCZ27_RS15755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CCZ27_RS15770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CCZ27_RS15770	COG0519	Catalyzes the synthesis of GMP from XMP
CCZ27_RS15775	COG4638	Rieske (2fe-2S)
CCZ27_RS15800	COG0392	lysyltransferase activity
CCZ27_RS15800	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CCZ27_RS15810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CCZ27_RS15815	COG0583	DNA-binding transcription factor activity
CCZ27_RS15830	COG1360	Flagellar Motor Protein
CCZ27_RS15845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CCZ27_RS15845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCZ27_RS15850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCZ27_RS15855	COG0577	efflux transmembrane transporter activity
CCZ27_RS15855	COG1136	(ABC) transporter
CCZ27_RS15860	COG1136	(ABC) transporter
CCZ27_RS15860	COG0577	efflux transmembrane transporter activity
CCZ27_RS15865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ27_RS15875	COG0723	plastoquinol--plastocyanin reductase activity
CCZ27_RS15890	COG1252	NADH dehydrogenase
CCZ27_RS15920	COG0183	Belongs to the thiolase family
CCZ27_RS15935	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CCZ27_RS15940	COG0145	ligase activity
CCZ27_RS15950	COG4647	ligase activity
CCZ27_RS15955	COG0145	ligase activity
CCZ27_RS15960	COG1309	transcriptional regulator
CCZ27_RS16000	COG1960	acyl-CoA dehydrogenase activity
CCZ27_RS16005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CCZ27_RS16015	COG0346	lactoylglutathione lyase activity
CCZ27_RS16025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CCZ27_RS16060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CCZ27_RS16085	COG0070	glutamate synthase
CCZ27_RS16085	COG0067	glutamate synthase
CCZ27_RS16085	COG0069	glutamate synthase activity
CCZ27_RS16090	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CCZ27_RS16095	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CCZ27_RS16100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CCZ27_RS16135	COG1965	Belongs to the frataxin family
CCZ27_RS16165	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CCZ27_RS16170	COG0284	orotidine-5'-phosphate decarboxylase activity
CCZ27_RS16180	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CCZ27_RS16185	COG3161	chorismate lyase activity
CCZ27_RS16190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CCZ27_RS16210	COG1024	Enoyl-CoA hydratase
CCZ27_RS16215	COG0183	Belongs to the thiolase family
CCZ27_RS16220	COG1250	3-hydroxyacyl-CoA dehydrogenase
CCZ27_RS16220	COG1024	Enoyl-CoA hydratase
CCZ27_RS16235	COG2814	Major facilitator Superfamily
CCZ27_RS16255	COG4638	Rieske (2fe-2S)
CCZ27_RS16290	COG5265	(ABC) transporter
CCZ27_RS16305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCZ27_RS16310	COG0765	amino acid transport
CCZ27_RS16315	COG0765	amino acid transport
CCZ27_RS16320	COG1126	abc transporter atp-binding protein
CCZ27_RS16330	COG0583	DNA-binding transcription factor activity
CCZ27_RS16335	COG0730	response to heat
CCZ27_RS16350	COG0175	sulfate reduction
CCZ27_RS16355	COG0175	sulfate reduction
CCZ27_RS16360	COG2895	sulfate adenylyltransferase (ATP) activity
CCZ27_RS16365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CCZ27_RS16385	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CCZ27_RS16390	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CCZ27_RS16400	COG0824	Thioesterase
CCZ27_RS16420	COG0823	Involved in the tonB-independent uptake of proteins
CCZ27_RS16435	COG0602	queuosine metabolic process
CCZ27_RS16440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CCZ27_RS16460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CCZ27_RS16480	COG0745	RESPONSE REGULATOR receiver
CCZ27_RS16485	COG4251	negative regulation of phosphorylation
CCZ27_RS16495	COG0318	PFAM AMP-dependent synthetase and ligase
CCZ27_RS16505	COG0412	Dienelactone hydrolase
CCZ27_RS16520	COG1660	Displays ATPase and GTPase activities
CCZ27_RS16545	COG0318	PFAM AMP-dependent synthetase and ligase
CCZ27_RS16565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CCZ27_RS16605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CCZ27_RS16610	COG0318	PFAM AMP-dependent synthetase and ligase
CCZ27_RS16615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CCZ27_RS16665	COG1960	acyl-CoA dehydrogenase activity
CCZ27_RS16700	COG1960	acyl-CoA dehydrogenase activity
CCZ27_RS16705	COG0183	Belongs to the thiolase family
CCZ27_RS16710	COG0288	reversible hydration of carbon dioxide
CCZ27_RS16720	COG0789	Transcriptional regulator
CCZ27_RS16730	COG3243	poly(R)-hydroxyalkanoic acid synthase
CCZ27_RS16740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CCZ27_RS16750	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CCZ27_RS16760	COG0018	arginyl-trna synthetase
CCZ27_RS16785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CCZ27_RS16800	COG0826	peptidase U32
CCZ27_RS16805	COG0826	peptidase U32
CCZ27_RS16810	COG3154	lipid carrier protein
CCZ27_RS16815	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CCZ27_RS16820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CCZ27_RS16825	COG1546	Belongs to the CinA family
CCZ27_RS16830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CCZ27_RS16835	COG2137	regulation of response to DNA damage stimulus
CCZ27_RS16840	COG1137	ATPase activity
CCZ27_RS16845	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CCZ27_RS16850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CCZ27_RS16860	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CCZ27_RS16865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CCZ27_RS16870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CCZ27_RS16875	COG0741	lytic transglycosylase activity
CCZ27_RS16880	COG0702	epimerase
CCZ27_RS16890	COG0617	tRNA 3'-terminal CCA addition
CCZ27_RS16900	COG0625	glutathione transferase activity
CCZ27_RS16905	COG2267	carboxylic ester hydrolase activity
CCZ27_RS16925	COG0295	cytidine deaminase activity
CCZ27_RS16930	COG1028	Short-chain dehydrogenase reductase Sdr
CCZ27_RS16935	COG0037	tRNA processing
CCZ27_RS16955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CCZ27_RS16960	COG0243	molybdopterin cofactor binding
CCZ27_RS16970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CCZ27_RS16975	COG0708	Exodeoxyribonuclease III
CCZ27_RS17010	COG4575	ribosome binding
CCZ27_RS17025	COG0037	tRNA processing
CCZ27_RS17025	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CCZ27_RS17050	COG0583	DNA-binding transcription factor activity
CCZ27_RS17060	COG4774	siderophore transport
CCZ27_RS17080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CCZ27_RS17100	COG1902	pentaerythritol trinitrate reductase activity
CCZ27_RS17120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CCZ27_RS17125	COG0830	nickel cation binding
CCZ27_RS17130	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CCZ27_RS17135	COG0804	urea catabolic process
CCZ27_RS17140	COG0832	Belongs to the urease beta subunit family
CCZ27_RS17145	COG0831	urea catabolic process
CCZ27_RS17150	COG0829	nickel cation binding
CCZ27_RS17230	COG1215	transferase activity, transferring glycosyl groups
CCZ27_RS17240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CCZ27_RS17245	COG0668	transmembrane transport
CCZ27_RS17255	COG0251	oxidation-reduction process
CCZ27_RS17265	COG0180	Tryptophanyl-tRNA synthetase
CCZ27_RS17280	COG3876	Protein conserved in bacteria
CCZ27_RS17285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CCZ27_RS17290	COG3781	membrane
CCZ27_RS17295	COG1966	Carbon starvation protein
CCZ27_RS17300	COG2879	small protein
CCZ27_RS17305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CCZ27_RS17325	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CCZ27_RS17360	COG1160	GTP binding
CCZ27_RS17365	COG1160	GTP binding
CCZ27_RS17440	COG0347	Belongs to the P(II) protein family
CCZ27_RS17445	COG0004	ammonium transporteR
CCZ27_RS17455	COG0788	formyltetrahydrofolate deformylase activity
CCZ27_RS17460	COG0560	Phosphoserine phosphatase
CCZ27_RS17470	COG0488	(ABC) transporter
CCZ27_RS17500	COG3383	formate dehydrogenase (NAD+) activity
CCZ27_RS17505	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CCZ27_RS17520	COG0697	spore germination
CCZ27_RS17525	COG3135	benzoate transporter
CCZ27_RS17540	COG0189	ligase activity
CCZ27_RS17565	COG2200	EAL domain
CCZ27_RS17565	COG2203	Gaf domain
CCZ27_RS17565	COG2199	diguanylate cyclase activity
CCZ27_RS17570	COG3437	response regulator, receiver
CCZ27_RS17625	COG4120	Belongs to the binding-protein-dependent transport system permease family
CCZ27_RS17630	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CCZ27_RS17655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CCZ27_RS17660	COG1074	ATP-dependent DNA helicase activity
CCZ27_RS17685	COG2308	Evidence 4 Homologs of previously reported genes of
CCZ27_RS17720	COG0625	glutathione transferase activity
CCZ27_RS17725	COG0861	Integral membrane protein TerC family
CCZ27_RS17745	COG4232	protein-disulfide reductase activity
CCZ27_RS17760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CCZ27_RS17765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CCZ27_RS17775	COG0432	Pfam Uncharacterised protein family UPF0047
CCZ27_RS17780	COG0513	Belongs to the DEAD box helicase family
CCZ27_RS17815	COG1960	acyl-CoA dehydrogenase activity
CCZ27_RS17830	COG0183	Belongs to the thiolase family
CCZ27_RS17835	COG1024	Enoyl-CoA hydratase
CCZ27_RS17855	COG1607	acyl-coa hydrolase
CCZ27_RS17890	COG3327	negative regulation of DNA-templated transcription, initiation
CCZ27_RS17900	COG1024	Enoyl-CoA hydratase
CCZ27_RS17905	COG1250	3-hydroxyacyl-CoA dehydrogenase
CCZ27_RS17910	COG2050	protein possibly involved in aromatic compounds catabolism
CCZ27_RS17920	COG0183	Belongs to the thiolase family
CCZ27_RS17930	COG3396	Phenylacetate-CoA oxygenase
CCZ27_RS17935	COG3460	Phenylacetate-CoA oxygenase
CCZ27_RS17940	COG3396	Phenylacetate-CoA oxygenase
CCZ27_RS17945	COG2151	metal-sulfur cluster biosynthetic enzyme
CCZ27_RS17950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CCZ27_RS17955	COG1042	CoA-binding domain protein
CCZ27_RS17955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CCZ27_RS17955	COG0045	succinate-CoA ligase (ADP-forming) activity
CCZ27_RS17965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CCZ27_RS18010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CCZ27_RS18015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CCZ27_RS18050	COG0559	Belongs to the binding-protein-dependent transport system permease family
CCZ27_RS18060	COG1970	mechanosensitive ion channel activity
CCZ27_RS18065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CCZ27_RS18070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CCZ27_RS18080	COG1652	LysM domain
CCZ27_RS18095	COG0584	glycerophosphoryl diester phosphodiesterase
CCZ27_RS18115	COG2226	methyltransferase
CCZ27_RS18125	COG0861	Integral membrane protein TerC family
CCZ27_RS18130	COG1858	cytochrome C peroxidase
CCZ27_RS18140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CCZ27_RS18145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CCZ27_RS18150	COG2207	Transcriptional regulator
CCZ27_RS18205	COG3209	COG3209 Rhs family protein
CCZ27_RS18245	COG0826	peptidase U32
CCZ27_RS18250	COG0488	(ABC) transporter
CCZ27_RS18260	COG2353	YceI-like domain
CCZ27_RS18265	COG1741	Belongs to the pirin family
CCZ27_RS18285	COG3485	protocatechuate 3,4-dioxygenase
CCZ27_RS18290	COG0183	Belongs to the thiolase family
CCZ27_RS18325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CCZ27_RS18335	COG1012	belongs to the aldehyde dehydrogenase family
CCZ27_RS18360	COG0655	NAD(P)H dehydrogenase (quinone) activity
CCZ27_RS18370	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCZ27_RS18375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCZ27_RS18380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCZ27_RS18390	COG0582	viral genome integration into host DNA
CCZ27_RS18625	COG0640	Transcriptional regulator
CCZ27_RS18630	COG0346	lactoylglutathione lyase activity
CCZ27_RS18640	COG0798	PFAM Bile acid sodium symporter
CCZ27_RS18655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CCZ27_RS18695	COG1192	Involved in chromosome partitioning
CCZ27_RS18710	COG0583	DNA-binding transcription factor activity
CCZ27_RS18715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CCZ27_RS18725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCZ27_RS18750	COG0640	Transcriptional regulator
CCZ27_RS18765	COG2814	Major facilitator Superfamily
CCZ27_RS18775	COG1294	oxidase, subunit
CCZ27_RS18780	COG1271	oxidase subunit
CCZ27_RS18785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CCZ27_RS18790	COG4988	ABC transporter
CCZ27_RS18800	COG0640	Transcriptional regulator
CCZ27_RS18820	COG1309	transcriptional regulator
CCZ27_RS18825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ27_RS18835	COG1136	(ABC) transporter
CCZ27_RS18875	COG0672	)-iron permease
CCZ27_RS18890	COG0789	Transcriptional regulator
CCZ27_RS18895	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CCZ27_RS18920	COG0723	plastoquinol--plastocyanin reductase activity
CCZ27_RS18925	COG0450	alkyl hydroperoxide reductase
CCZ27_RS18930	COG0640	Transcriptional regulator
CCZ27_RS18960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CCZ27_RS18965	COG0583	DNA-binding transcription factor activity
CCZ27_RS18990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CCZ27_RS18995	COG4235	cytochrome complex assembly
CCZ27_RS19000	COG3088	subunit of a heme lyase
CCZ27_RS19005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CCZ27_RS19015	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CCZ27_RS19035	COG4133	protoheme IX ABC transporter activity
CCZ27_RS19045	COG3005	denitrification pathway
CCZ27_RS19055	COG0348	domain, Protein
CCZ27_RS19060	COG0437	4 iron, 4 sulfur cluster binding
CCZ27_RS19065	COG0243	molybdopterin cofactor binding
CCZ27_RS19075	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCZ27_RS19075	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCZ27_RS19080	COG2197	response regulator
CCZ27_RS19085	COG3850	Histidine kinase
CCZ27_RS19105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CCZ27_RS19110	COG1758	RNA polymerase activity
CCZ27_RS19115	COG0194	GDP metabolic process
CCZ27_RS19125	COG2375	cellular response to nickel ion
CCZ27_RS19135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCZ27_RS19140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ27_RS19185	COG0583	DNA-binding transcription factor activity
CCZ27_RS19200	COG0745	RESPONSE REGULATOR receiver
CCZ27_RS19205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ27_RS19210	COG1136	(ABC) transporter
CCZ27_RS19210	COG0577	efflux transmembrane transporter activity
CCZ27_RS19245	COG0714	Associated with various cellular activities
CCZ27_RS19255	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CCZ27_RS19270	COG0693	protein deglycase activity
CCZ27_RS19295	COG3608	succinylglutamate desuccinylase aspartoacylase
CCZ27_RS19295	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CCZ27_RS19305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CCZ27_RS19310	COG0861	Integral membrane protein TerC family
CCZ27_RS19315	COG0583	DNA-binding transcription factor activity
CCZ27_RS19320	COG0477	Major facilitator Superfamily
CCZ27_RS19375	COG1917	Cupin 2, conserved barrel domain protein
CCZ27_RS19375	COG4977	sequence-specific DNA binding
CCZ27_RS19385	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CCZ27_RS19390	COG1984	allophanate hydrolase subunit 2
CCZ27_RS19395	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CCZ27_RS19400	COG4676	Protein conserved in bacteria
CCZ27_RS19405	COG4676	Protein conserved in bacteria
CCZ27_RS19410	COG5445	Predicted secreted protein (DUF2300)
CCZ27_RS19430	COG2373	Large extracellular alpha-helical protein
CCZ27_RS19440	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
CCZ27_RS19485	COG0732	type I restriction modification DNA specificity domain
CCZ27_RS19490	COG4804	nuclease activity
CCZ27_RS19510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CCZ27_RS19590	COG4584	PFAM Integrase catalytic
CCZ27_RS19595	COG1484	DNA-dependent DNA replication
CCZ27_RS19600	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CCZ27_RS19605	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CCZ27_RS19660	COG1280	lysine exporter protein (LysE YggA)
CCZ27_RS19715	COG2249	NAD(P)H dehydrogenase (quinone) activity
CCZ27_RS19725	COG1561	YicC-like family, N-terminal region
CCZ27_RS19730	COG3266	domain, Protein
CCZ27_RS19730	COG0515	serine threonine protein kinase
CCZ27_RS19735	COG0631	protein serine/threonine phosphatase activity
CCZ27_RS19740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CCZ27_RS19745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CCZ27_RS19750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CCZ27_RS19760	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CCZ27_RS19765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCZ27_RS19770	COG4558	Periplasmic binding protein
CCZ27_RS19780	COG4771	TonB-dependent receptor
CCZ27_RS19790	COG1881	PFAM PEBP family protein
CCZ27_RS19795	COG0616	signal peptide processing
CCZ27_RS19800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CCZ27_RS19805	COG2022	thiamine diphosphate biosynthetic process
CCZ27_RS19815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CCZ27_RS19820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CCZ27_RS19820	COG2813	Specifically methylates the guanine in position
CCZ27_RS19835	COG2223	nitrite transmembrane transporter activity
CCZ27_RS19855	COG0288	reversible hydration of carbon dioxide
CCZ27_RS19860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CCZ27_RS19865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CCZ27_RS19875	COG0569	domain protein
CCZ27_RS19880	COG2204	response regulator
CCZ27_RS19895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CCZ27_RS19895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CCZ27_RS19900	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CCZ27_RS19925	COG0732	type I restriction modification DNA specificity domain
CCZ27_RS19940	COG0556	nucleotide-excision repair
CCZ27_RS19950	COG0582	viral genome integration into host DNA
CCZ27_RS19995	COG0582	viral genome integration into host DNA
CCZ27_RS20000	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CCZ27_RS20005	COG0706	membrane insertase activity
CCZ27_RS20010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CCZ27_RS20015	COG0594	ribonuclease P activity
CCZ27_RS20020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CCZ27_RS20025	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CCZ27_RS20050	COG4974	Belongs to the 'phage' integrase family
CCZ27_RS20055	COG3039	Transposase
CCZ27_RS20095	COG4974	Belongs to the 'phage' integrase family
CCZ27_RS20105	COG4453	Protein conserved in bacteria
CCZ27_RS20115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CCZ27_RS20125	COG2703	oxygen carrier activity
CCZ27_RS20145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CCZ27_RS20165	COG0840	transmembrane signaling receptor activity
CCZ27_RS20180	COG1127	ABC transporter
CCZ27_RS20185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CCZ27_RS20195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ27_RS20200	COG0842	Transport permease protein
CCZ27_RS20200	COG1129	ABC transporter
CCZ27_RS20205	COG0842	Transport permease protein
CCZ27_RS20210	COG3243	poly(R)-hydroxyalkanoic acid synthase
CCZ27_RS20250	COG3300	MHYT domain
CCZ27_RS20250	COG5001	Diguanylate cyclase
CCZ27_RS20275	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CCZ27_RS20280	COG2974	May be involved in recombination
CCZ27_RS20290	COG1187	pseudouridine synthase activity
CCZ27_RS20300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CCZ27_RS20315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CCZ27_RS20325	COG3909	cytochrome
CCZ27_RS20330	COG0840	transmembrane signaling receptor activity
CCZ27_RS20335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CCZ27_RS20340	COG4206	TonB-dependent receptor
CCZ27_RS20350	COG0783	Belongs to the Dps family
CCZ27_RS20355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CCZ27_RS20355	COG0551	DNA topoisomerase type I activity
CCZ27_RS20360	COG2922	Belongs to the Smg family
CCZ27_RS20365	COG0758	DNA mediated transformation
CCZ27_RS20375	COG0242	peptide deformylase activity
CCZ27_RS20380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CCZ27_RS20390	COG0243	molybdopterin cofactor binding
CCZ27_RS20390	COG3383	formate dehydrogenase (NAD+) activity
CCZ27_RS20395	COG3383	formate dehydrogenase (NAD+) activity
CCZ27_RS20395	COG0243	molybdopterin cofactor binding
CCZ27_RS20400	COG0437	4 iron, 4 sulfur cluster binding
CCZ27_RS20405	COG2864	formate dehydrogenase
CCZ27_RS20435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CCZ27_RS20460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CCZ27_RS20465	COG1309	transcriptional regulator
CCZ27_RS20485	COG0559	Belongs to the binding-protein-dependent transport system permease family
CCZ27_RS20500	COG0318	PFAM AMP-dependent synthetase and ligase
CCZ27_RS20510	COG0778	Nitroreductase
CCZ27_RS20545	COG0154	amidase activity
CCZ27_RS20565	COG4638	Rieske (2fe-2S)
CCZ27_RS20585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CCZ27_RS20675	COG3210	domain, Protein
CCZ27_RS20760	COG0789	Transcriptional regulator
CCZ27_RS20805	COG1028	Short-chain dehydrogenase reductase Sdr
CCZ27_RS20870	COG1063	alcohol dehydrogenase
CCZ27_RS20885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CCZ27_RS20890	COG3276	selenocysteine insertion sequence binding
CCZ27_RS20905	COG2119	membrane
CCZ27_RS20910	COG0583	DNA-binding transcription factor activity
CCZ27_RS20915	COG0167	dihydroorotate dehydrogenase activity
CCZ27_RS20920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CCZ27_RS20920	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CCZ27_RS20920	COG0674	pyruvate-flavodoxin oxidoreductase activity
CCZ27_RS20920	COG1013	pyruvate-flavodoxin oxidoreductase activity
CCZ27_RS20925	COG4178	(ABC) transporter
CCZ27_RS20930	COG1028	Short-chain dehydrogenase reductase Sdr
CCZ27_RS20935	COG4977	sequence-specific DNA binding
CCZ27_RS20940	COG3210	domain, Protein
CCZ27_RS20965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CCZ27_RS20970	COG1024	Enoyl-CoA hydratase
CCZ27_RS20985	COG1278	Cold shock
CCZ27_RS21000	COG1132	(ABC) transporter
CCZ27_RS21010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CCZ27_RS21045	COG2204	response regulator
CCZ27_RS21050	COG2610	gluconate transmembrane transporter activity
CCZ27_RS21060	COG0445	tRNA wobble uridine modification
CCZ27_RS21065	COG0357	Ribosomal RNA small subunit methyltransferase G
CCZ27_RS21070	COG1192	Involved in chromosome partitioning
CCZ27_RS21085	COG1475	DNA binding
CCZ27_RS21095	COG0477	Major facilitator Superfamily
CCZ27_RS21110	COG0640	Transcriptional regulator
CCZ27_RS21120	COG0356	it plays a direct role in the translocation of protons across the membrane
CCZ27_RS21130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CCZ27_RS21135	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CCZ27_RS21140	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CCZ27_RS21145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CCZ27_RS21150	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CCZ27_RS21155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CCZ27_RS21170	COG2226	methyltransferase
CCZ27_RS21180	COG0745	RESPONSE REGULATOR receiver
CCZ27_RS21200	COG0121	glutamine amidotransferase
CCZ27_RS21205	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CCZ27_RS21215	COG0154	amidase activity
CCZ27_RS21220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CCZ27_RS21225	COG1077	Cell shape determining protein MreB Mrl
CCZ27_RS21240	COG0768	penicillin binding
CCZ27_RS21245	COG0772	Belongs to the SEDS family
CCZ27_RS21250	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CCZ27_RS21255	COG1686	Belongs to the peptidase S11 family
CCZ27_RS21265	COG2921	Belongs to the UPF0250 family
CCZ27_RS21270	COG0321	lipoyl(octanoyl) transferase activity
CCZ27_RS21275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CCZ27_RS21310	COG2814	Major facilitator Superfamily
CCZ27_RS21315	COG3189	MarR family transcriptional regulator
CCZ27_RS21320	COG0309	Hydrogenase expression formation protein (HypE)
CCZ27_RS21325	COG0409	Hydrogenase expression formation protein
CCZ27_RS21330	COG0298	carbon dioxide binding
CCZ27_RS21350	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CCZ27_RS21355	COG3383	formate dehydrogenase (NAD+) activity
CCZ27_RS21360	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
CCZ27_RS21365	COG3259	Nickel-dependent hydrogenase
CCZ27_RS21380	COG3842	ATPase activity
CCZ27_RS21385	COG1176	ABC-type spermidine putrescine transport system, permease component I
CCZ27_RS21390	COG1177	transmembrane transport
CCZ27_RS21400	COG3045	CreA protein
CCZ27_RS21415	COG3409	Peptidoglycan-binding domain 1 protein
CCZ27_RS21415	COG3773	Cell wall hydrolase
CCZ27_RS21450	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CCZ27_RS21485	COG0419	ATPase involved in DNA repair
CCZ27_RS21525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCZ27_RS21530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCZ27_RS21540	COG0523	cobalamin synthesis protein
CCZ27_RS21550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CCZ27_RS21580	COG1959	2 iron, 2 sulfur cluster binding
CCZ27_RS21585	COG2902	Dehydrogenase
CCZ27_RS21595	COG2095	MarC family integral membrane protein
CCZ27_RS21610	COG3447	MASE1 domain protein
CCZ27_RS21610	COG5001	Diguanylate cyclase
CCZ27_RS21610	COG5002	protein histidine kinase activity
CCZ27_RS21615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CCZ27_RS21650	COG2192	nodulation
CCZ27_RS21655	COG2832	Protein of unknown function (DUF454)
CCZ27_RS21660	COG0628	permease
CCZ27_RS21685	COG1858	cytochrome C peroxidase
CCZ27_RS21690	COG0583	DNA-binding transcription factor activity
CCZ27_RS21700	COG4115	mRNA cleavage
CCZ27_RS21705	COG2161	toxin-antitoxin pair type II binding
CCZ27_RS21715	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
CCZ27_RS21730	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CCZ27_RS21735	COG0393	Putative heavy-metal-binding
CCZ27_RS21740	COG0217	transcriptional regulatory protein
CCZ27_RS21745	COG0433	COG0433 Predicted ATPase
CCZ27_RS21760	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CCZ27_RS21765	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CCZ27_RS21770	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CCZ27_RS21775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CCZ27_RS21785	COG1560	Kdo2-lipid A biosynthetic process
CCZ27_RS21790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CCZ27_RS21800	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CCZ27_RS21815	COG2255	four-way junction helicase activity
CCZ27_RS21820	COG0632	four-way junction helicase activity
CCZ27_RS21835	COG0424	maF-like protein
CCZ27_RS21840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CCZ27_RS21845	COG0799	negative regulation of ribosome biogenesis
CCZ27_RS21850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CCZ27_RS21865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CCZ27_RS21935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CCZ27_RS21955	COG2161	toxin-antitoxin pair type II binding
CCZ27_RS21970	COG0438	transferase activity, transferring glycosyl groups
CCZ27_RS21985	COG0438	transferase activity, transferring glycosyl groups
CCZ27_RS21995	COG0438	transferase activity, transferring glycosyl groups
CCZ27_RS22020	COG1132	(ABC) transporter
CCZ27_RS22030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CCZ27_RS22030	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CCZ27_RS22045	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CCZ27_RS22050	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CCZ27_RS22055	COG4269	membrane
CCZ27_RS22060	COG0501	Belongs to the peptidase M48B family
CCZ27_RS22085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCZ27_RS22090	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CCZ27_RS22100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CCZ27_RS22105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CCZ27_RS22105	COG1648	precorrin-2 dehydrogenase activity
CCZ27_RS22140	COG0688	phosphatidylethanolamine metabolic process
CCZ27_RS22150	COG0427	acetyl-CoA hydrolase
CCZ27_RS22155	COG0513	Belongs to the DEAD box helicase family
CCZ27_RS22175	COG1492	cobalamin metabolic process
CCZ27_RS22180	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CCZ27_RS22180	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CCZ27_RS22190	COG4654	Cytochrome c, class I
CCZ27_RS22200	COG5002	protein histidine kinase activity
CCZ27_RS22205	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CCZ27_RS22210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CCZ27_RS22210	COG0543	2 iron, 2 sulfur cluster binding
CCZ27_RS22220	COG1981	membrane
CCZ27_RS22235	COG0746	molybdenum cofactor guanylyltransferase activity
CCZ27_RS22270	COG1872	DUF167
CCZ27_RS22280	COG0540	Belongs to the ATCase OTCase family
CCZ27_RS22285	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CCZ27_RS22290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CCZ27_RS22295	COG1678	Uncharacterized ACR, COG1678
CCZ27_RS22300	COG0415	Belongs to the DNA photolyase family
CCZ27_RS22305	COG0643	Histidine kinase
CCZ27_RS22305	COG2198	Histidine kinase
CCZ27_RS22310	COG0840	transmembrane signaling receptor activity
CCZ27_RS22330	COG1773	rubredoxin
CCZ27_RS22340	COG0352	thiamine-phosphate diphosphorylase activity
CCZ27_RS22345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CCZ27_RS22350	COG3851	Histidine kinase
CCZ27_RS22365	COG2239	Acts as a magnesium transporter
CCZ27_RS22370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CCZ27_RS22380	COG0557	exoribonuclease II activity
CCZ27_RS22395	COG3150	esterase
CCZ27_RS22400	COG1968	undecaprenyl-diphosphatase activity
CCZ27_RS22405	COG1618	nucleotide phosphatase activity, acting on free nucleotides
CCZ27_RS22405	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CCZ27_RS22410	COG1643	Atp-dependent helicase
CCZ27_RS22420	COG0360	Binds together with S18 to 16S ribosomal RNA
CCZ27_RS22425	COG2965	DNA replication, synthesis of RNA primer
CCZ27_RS22430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CCZ27_RS22435	COG0359	binds to the 23S rRNA
CCZ27_RS22440	COG0305	Participates in initiation and elongation during chromosome replication
CCZ27_RS22495	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CCZ27_RS22505	COG1902	pentaerythritol trinitrate reductase activity
CCZ27_RS22535	COG1335	isochorismatase
CCZ27_RS22600	COG2003	Belongs to the UPF0758 family
CCZ27_RS22630	COG1484	DNA-dependent DNA replication
CCZ27_RS22690	COG1879	ABC-type sugar transport system periplasmic component
CCZ27_RS22695	COG3706	GGDEF domain
CCZ27_RS22770	COG3436	PFAM IS66 Orf2 family protein
CCZ27_RS22775	COG4372	Transposase
CCZ27_RS22795	COG2135	peptidase activity
CCZ27_RS22825	COG3577	Aspartyl protease
CCZ27_RS22930	COG0789	Transcriptional regulator
CCZ27_RS22945	COG4974	Belongs to the 'phage' integrase family
CCZ27_RS22985	COG4372	Transposase
CCZ27_RS23015	COG4962	Type ii secretion system protein e
CCZ27_RS23020	COG3838	Conjugal transfer protein Trbc
CCZ27_RS23025	COG5268	conjugation
CCZ27_RS23030	COG3451	type IV secretory pathway VirB4
CCZ27_RS23040	COG3504	Conjugal transfer protein
CCZ27_RS23115	COG2356	endonuclease I
CCZ27_RS23125	COG0776	regulation of translation
CCZ27_RS23160	COG4453	Protein conserved in bacteria
CCZ27_RS23175	COG3550	peptidyl-serine autophosphorylation