locus-tag	class	description
TMZ1T_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TMZ1T_RS00020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TMZ1T_RS00025	COG0732	type I restriction modification DNA specificity domain
TMZ1T_RS00030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TMZ1T_RS00045	COG4584	PFAM Integrase catalytic
TMZ1T_RS00115	COG5433	transposase activity
TMZ1T_RS00165	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TMZ1T_RS00170	COG3657	addiction module killer protein
TMZ1T_RS00185	COG2161	toxin-antitoxin pair type II binding
TMZ1T_RS00205	COG4942	peptidase
TMZ1T_RS00225	COG1136	(ABC) transporter
TMZ1T_RS00225	COG0577	efflux transmembrane transporter activity
TMZ1T_RS00245	COG0443	Heat shock 70 kDa protein
TMZ1T_RS00265	COG1451	nucleotide metabolic process
TMZ1T_RS00305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TMZ1T_RS00325	COG0142	geranyltranstransferase activity
TMZ1T_RS00330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TMZ1T_RS00345	COG1132	(ABC) transporter
TMZ1T_RS00380	COG1404	Belongs to the peptidase S8 family
TMZ1T_RS00390	COG1024	Enoyl-CoA hydratase
TMZ1T_RS00395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TMZ1T_RS00410	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TMZ1T_RS00415	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TMZ1T_RS00420	COG0501	Belongs to the peptidase M48B family
TMZ1T_RS00425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TMZ1T_RS00430	COG0242	peptide deformylase activity
TMZ1T_RS00440	COG0758	DNA mediated transformation
TMZ1T_RS00445	COG2922	Belongs to the Smg family
TMZ1T_RS00455	COG1522	sequence-specific DNA binding
TMZ1T_RS00465	COG0783	Belongs to the Dps family
TMZ1T_RS00475	COG4206	TonB-dependent receptor
TMZ1T_RS00480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TMZ1T_RS00485	COG0840	transmembrane signaling receptor activity
TMZ1T_RS00490	COG3909	cytochrome
TMZ1T_RS00505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TMZ1T_RS00530	COG3177	Filamentation induced by cAMP protein fic
TMZ1T_RS00550	COG0583	DNA-binding transcription factor activity
TMZ1T_RS00555	COG0477	Major facilitator Superfamily
TMZ1T_RS00570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TMZ1T_RS00600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TMZ1T_RS00615	COG1187	pseudouridine synthase activity
TMZ1T_RS00625	COG2974	May be involved in recombination
TMZ1T_RS00650	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
TMZ1T_RS00660	COG1473	amidohydrolase
TMZ1T_RS00670	COG0583	DNA-binding transcription factor activity
TMZ1T_RS00675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TMZ1T_RS00685	COG0114	fumarate hydratase activity
TMZ1T_RS00690	COG3835	regulator
TMZ1T_RS00695	COG1929	Belongs to the glycerate kinase type-1 family
TMZ1T_RS00700	COG0679	Auxin Efflux Carrier
TMZ1T_RS00725	COG1607	acyl-coa hydrolase
TMZ1T_RS00735	COG0642	Histidine kinase
TMZ1T_RS00755	COG1902	pentaerythritol trinitrate reductase activity
TMZ1T_RS00765	COG0390	transport system, permease component
TMZ1T_RS00770	COG1116	anion transmembrane transporter activity
TMZ1T_RS00780	COG3264	Mechanosensitive ion channel
TMZ1T_RS00780	COG1196	nuclear chromosome segregation
TMZ1T_RS00785	COG0477	Major facilitator Superfamily
TMZ1T_RS00790	COG2816	NAD+ diphosphatase activity
TMZ1T_RS00825	COG1575	Belongs to the MenA family. Type 1 subfamily
TMZ1T_RS00835	COG3851	Histidine kinase
TMZ1T_RS00840	COG2197	response regulator
TMZ1T_RS00855	COG1192	Involved in chromosome partitioning
TMZ1T_RS00880	COG3243	poly(R)-hydroxyalkanoic acid synthase
TMZ1T_RS00890	COG0574	Belongs to the PEP-utilizing enzyme family
TMZ1T_RS00890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TMZ1T_RS00900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMZ1T_RS00910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TMZ1T_RS00910	COG1017	nitric oxide dioxygenase activity
TMZ1T_RS00920	COG3327	negative regulation of DNA-templated transcription, initiation
TMZ1T_RS00935	COG0243	molybdopterin cofactor binding
TMZ1T_RS00940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TMZ1T_RS00950	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TMZ1T_RS00960	COG0445	tRNA wobble uridine modification
TMZ1T_RS00965	COG0357	Ribosomal RNA small subunit methyltransferase G
TMZ1T_RS00970	COG1192	Involved in chromosome partitioning
TMZ1T_RS00975	COG1475	DNA binding
TMZ1T_RS00985	COG0356	it plays a direct role in the translocation of protons across the membrane
TMZ1T_RS00995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TMZ1T_RS01000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TMZ1T_RS01005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TMZ1T_RS01010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TMZ1T_RS01015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TMZ1T_RS01020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TMZ1T_RS01035	COG2226	methyltransferase
TMZ1T_RS01075	COG0745	RESPONSE REGULATOR receiver
TMZ1T_RS01095	COG0121	glutamine amidotransferase
TMZ1T_RS01100	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TMZ1T_RS01110	COG0154	amidase activity
TMZ1T_RS01115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TMZ1T_RS01120	COG1077	Cell shape determining protein MreB Mrl
TMZ1T_RS01135	COG0768	penicillin binding
TMZ1T_RS01140	COG0772	Belongs to the SEDS family
TMZ1T_RS01150	COG1686	Belongs to the peptidase S11 family
TMZ1T_RS01155	COG2921	Belongs to the UPF0250 family
TMZ1T_RS01160	COG0321	lipoyl(octanoyl) transferase activity
TMZ1T_RS01165	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TMZ1T_RS01180	COG2703	oxygen carrier activity
TMZ1T_RS01185	COG0210	DNA helicase
TMZ1T_RS01240	COG4974	Belongs to the 'phage' integrase family
TMZ1T_RS01245	COG0517	IMP dehydrogenase activity
TMZ1T_RS01255	COG0861	Integral membrane protein TerC family
TMZ1T_RS01260	COG1253	flavin adenine dinucleotide binding
TMZ1T_RS01265	COG0501	Belongs to the peptidase M48B family
TMZ1T_RS01270	COG0628	permease
TMZ1T_RS01280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TMZ1T_RS01295	COG2433	Pfam Transposase IS66
TMZ1T_RS01320	COG4372	Transposase
TMZ1T_RS01335	COG2433	Pfam Transposase IS66
TMZ1T_RS01350	COG2135	peptidase activity
TMZ1T_RS01370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TMZ1T_RS01500	COG4584	PFAM Integrase catalytic
TMZ1T_RS01520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMZ1T_RS01540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TMZ1T_RS01570	COG0583	DNA-binding transcription factor activity
TMZ1T_RS01580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TMZ1T_RS01680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TMZ1T_RS01690	COG5002	protein histidine kinase activity
TMZ1T_RS01700	COG0437	4 iron, 4 sulfur cluster binding
TMZ1T_RS01705	COG0243	molybdopterin cofactor binding
TMZ1T_RS01745	COG4372	Transposase
TMZ1T_RS01750	COG4974	Belongs to the 'phage' integrase family
TMZ1T_RS01755	COG0582	viral genome integration into host DNA
TMZ1T_RS01760	COG4974	Belongs to the 'phage' integrase family
TMZ1T_RS01765	COG4974	Belongs to the 'phage' integrase family
TMZ1T_RS01800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TMZ1T_RS01805	COG0573	inorganic phosphate transmembrane transporter activity
TMZ1T_RS01810	COG0573	inorganic phosphate transmembrane transporter activity
TMZ1T_RS01815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TMZ1T_RS01820	COG2204	response regulator
TMZ1T_RS01825	COG3852	Histidine kinase
TMZ1T_RS01845	COG0243	molybdopterin cofactor binding
TMZ1T_RS01885	COG3530	Putative quorum-sensing-regulated virulence factor
TMZ1T_RS01890	COG0420	3'-5' exonuclease activity
TMZ1T_RS01940	COG1172	Belongs to the binding-protein-dependent transport system permease family
TMZ1T_RS01955	COG1022	Amp-dependent synthetase and ligase
TMZ1T_RS01960	COG1024	Enoyl-CoA hydratase
TMZ1T_RS01965	COG1960	acyl-CoA dehydrogenase activity
TMZ1T_RS01970	COG0183	Belongs to the thiolase family
TMZ1T_RS01985	COG1959	2 iron, 2 sulfur cluster binding
TMZ1T_RS01995	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TMZ1T_RS02005	COG2095	MarC family integral membrane protein
TMZ1T_RS02010	COG0583	DNA-binding transcription factor activity
TMZ1T_RS02015	COG1960	acyl-CoA dehydrogenase activity
TMZ1T_RS02020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TMZ1T_RS02040	COG3842	ATPase activity
TMZ1T_RS02050	COG1176	ABC-type spermidine putrescine transport system, permease component I
TMZ1T_RS02055	COG1177	transmembrane transport
TMZ1T_RS02070	COG0579	oxidoreductase
TMZ1T_RS02075	COG2358	TRAP transporter, solute receptor (TAXI family
TMZ1T_RS02115	COG0513	Belongs to the DEAD box helicase family
TMZ1T_RS02130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TMZ1T_RS02135	COG1194	a g-specific adenine glycosylase
TMZ1T_RS02165	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMZ1T_RS02175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TMZ1T_RS02180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TMZ1T_RS02185	COG1652	LysM domain
TMZ1T_RS02200	COG2860	membrane
TMZ1T_RS02205	COG0004	ammonium transporteR
TMZ1T_RS02210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TMZ1T_RS02215	COG0569	domain protein
TMZ1T_RS02250	COG2233	PERMEase
TMZ1T_RS02260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TMZ1T_RS02265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMZ1T_RS02270	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMZ1T_RS02280	COG0488	(ABC) transporter
TMZ1T_RS02290	COG2197	response regulator
TMZ1T_RS02300	COG4585	Histidine kinase
TMZ1T_RS02340	COG5433	transposase activity
TMZ1T_RS02360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TMZ1T_RS02370	COG2226	methyltransferase
TMZ1T_RS02400	COG2267	carboxylic ester hydrolase activity
TMZ1T_RS02405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMZ1T_RS02410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TMZ1T_RS02440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMZ1T_RS02445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TMZ1T_RS02455	COG0523	cobalamin synthesis protein
TMZ1T_RS02465	COG2703	oxygen carrier activity
TMZ1T_RS02505	COG1739	Uncharacterized protein family UPF0029
TMZ1T_RS02510	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TMZ1T_RS02515	COG1984	allophanate hydrolase subunit 2
TMZ1T_RS02520	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TMZ1T_RS02545	COG0583	DNA-binding transcription factor activity
TMZ1T_RS02550	COG1760	l-serine dehydratase
TMZ1T_RS02555	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
TMZ1T_RS02570	COG3046	protein related to deoxyribodipyrimidine photolyase
TMZ1T_RS02575	COG5001	Diguanylate cyclase
TMZ1T_RS02580	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TMZ1T_RS02620	COG1414	Transcriptional regulator
TMZ1T_RS02625	COG0277	FAD linked oxidase domain protein
TMZ1T_RS02630	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMZ1T_RS02630	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TMZ1T_RS02635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TMZ1T_RS02635	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TMZ1T_RS02640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TMZ1T_RS02675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TMZ1T_RS02685	COG0827	DNA restriction-modification system
TMZ1T_RS02685	COG0732	type I restriction modification DNA specificity domain
TMZ1T_RS02695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TMZ1T_RS02700	COG0642	Histidine kinase
TMZ1T_RS02710	COG3174	membrane
TMZ1T_RS02755	COG0683	leucine binding
TMZ1T_RS02765	COG1522	sequence-specific DNA binding
TMZ1T_RS02770	COG3158	transport of potassium into the cell
TMZ1T_RS02780	COG0189	ligase activity
TMZ1T_RS02800	COG0697	spore germination
TMZ1T_RS02815	COG0488	(ABC) transporter
TMZ1T_RS02830	COG0788	formyltetrahydrofolate deformylase activity
TMZ1T_RS02840	COG2423	ornithine cyclodeaminase activity
TMZ1T_RS02845	COG0527	aspartate kinase activity
TMZ1T_RS02875	COG0004	ammonium transporteR
TMZ1T_RS02880	COG0347	Belongs to the P(II) protein family
TMZ1T_RS02900	COG2814	Major facilitator Superfamily
TMZ1T_RS02925	COG0683	leucine binding
TMZ1T_RS02945	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
TMZ1T_RS02950	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TMZ1T_RS02955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TMZ1T_RS02960	COG0583	DNA-binding transcription factor activity
TMZ1T_RS02975	COG3781	membrane
TMZ1T_RS02980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TMZ1T_RS02985	COG0659	secondary active sulfate transmembrane transporter activity
TMZ1T_RS02990	COG3876	Protein conserved in bacteria
TMZ1T_RS03010	COG0180	Tryptophanyl-tRNA synthetase
TMZ1T_RS03015	COG0583	DNA-binding transcription factor activity
TMZ1T_RS03020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TMZ1T_RS03025	COG4208	sulfate ABC transporter
TMZ1T_RS03045	COG0446	pyridine nucleotide-disulphide oxidoreductase
TMZ1T_RS03050	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TMZ1T_RS03055	COG4221	oxidoreductase activity
TMZ1T_RS03065	COG0471	metal ion transport
TMZ1T_RS03065	COG3273	potassium ion transport
TMZ1T_RS03075	COG2319	Wd-40 repeat
TMZ1T_RS03075	COG4249	Peptidase C14 caspase catalytic subunit p20
TMZ1T_RS03080	COG0583	DNA-binding transcription factor activity
TMZ1T_RS03095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TMZ1T_RS03115	COG1305	Transglutaminase-like
TMZ1T_RS03120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TMZ1T_RS03125	COG1024	Enoyl-CoA hydratase
TMZ1T_RS03135	COG2814	Major facilitator Superfamily
TMZ1T_RS03140	COG2814	Major facilitator Superfamily
TMZ1T_RS03155	COG1607	acyl-coa hydrolase
TMZ1T_RS03200	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TMZ1T_RS03225	COG4263	nitrous-oxide reductase activity
TMZ1T_RS03235	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TMZ1T_RS03255	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TMZ1T_RS03260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TMZ1T_RS03265	COG2233	PERMEase
TMZ1T_RS03280	COG4575	ribosome binding
TMZ1T_RS03285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TMZ1T_RS03300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TMZ1T_RS03310	COG0577	efflux transmembrane transporter activity
TMZ1T_RS03310	COG1136	(ABC) transporter
TMZ1T_RS03335	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TMZ1T_RS03345	COG0243	molybdopterin cofactor binding
TMZ1T_RS03360	COG0251	oxidation-reduction process
TMZ1T_RS03365	COG1238	metal cluster binding
TMZ1T_RS03380	COG0037	tRNA processing
TMZ1T_RS03400	COG0617	tRNA 3'-terminal CCA addition
TMZ1T_RS03415	COG0741	lytic transglycosylase activity
TMZ1T_RS03420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TMZ1T_RS03425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TMZ1T_RS03430	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TMZ1T_RS03440	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TMZ1T_RS03445	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TMZ1T_RS03455	COG2137	regulation of response to DNA damage stimulus
TMZ1T_RS03460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TMZ1T_RS03465	COG1546	Belongs to the CinA family
TMZ1T_RS03470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TMZ1T_RS03475	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TMZ1T_RS03480	COG3154	lipid carrier protein
TMZ1T_RS03485	COG0826	peptidase U32
TMZ1T_RS03490	COG0826	peptidase U32
TMZ1T_RS03500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TMZ1T_RS03505	COG0018	arginyl-trna synthetase
TMZ1T_RS03515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TMZ1T_RS03535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TMZ1T_RS03545	COG3243	poly(R)-hydroxyalkanoic acid synthase
TMZ1T_RS03560	COG0288	reversible hydration of carbon dioxide
TMZ1T_RS03565	COG0183	Belongs to the thiolase family
TMZ1T_RS03570	COG1960	acyl-CoA dehydrogenase activity
TMZ1T_RS03590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TMZ1T_RS03590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TMZ1T_RS03640	COG1960	acyl-CoA dehydrogenase activity
TMZ1T_RS03645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TMZ1T_RS03660	COG0318	PFAM AMP-dependent synthetase and ligase
TMZ1T_RS03685	COG1132	(ABC) transporter
TMZ1T_RS03730	COG1012	belongs to the aldehyde dehydrogenase family
TMZ1T_RS03740	COG0826	peptidase U32
TMZ1T_RS03750	COG1115	amino acid carrier protein
TMZ1T_RS03755	COG1660	Displays ATPase and GTPase activities
TMZ1T_RS03770	COG0412	Dienelactone hydrolase
TMZ1T_RS03775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TMZ1T_RS03795	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TMZ1T_RS03800	COG0602	queuosine metabolic process
TMZ1T_RS03810	COG2885	chlorophyll binding
TMZ1T_RS03815	COG0823	Involved in the tonB-independent uptake of proteins
TMZ1T_RS03835	COG0824	Thioesterase
TMZ1T_RS03845	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TMZ1T_RS03850	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TMZ1T_RS03860	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TMZ1T_RS03870	COG2895	sulfate adenylyltransferase (ATP) activity
TMZ1T_RS03875	COG0175	sulfate reduction
TMZ1T_RS03880	COG0175	sulfate reduction
TMZ1T_RS03895	COG0730	response to heat
TMZ1T_RS03900	COG0583	DNA-binding transcription factor activity
TMZ1T_RS03905	COG0252	asparaginase activity
TMZ1T_RS03915	COG5265	(ABC) transporter
TMZ1T_RS03935	COG1024	Enoyl-CoA hydratase
TMZ1T_RS03935	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMZ1T_RS03945	COG1024	Enoyl-CoA hydratase
TMZ1T_RS03945	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMZ1T_RS03950	COG0183	Belongs to the thiolase family
TMZ1T_RS03960	COG1805	sodium ion transport
TMZ1T_RS04000	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TMZ1T_RS04010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TMZ1T_RS04015	COG3161	chorismate lyase activity
TMZ1T_RS04020	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TMZ1T_RS04025	COG0284	orotidine-5'-phosphate decarboxylase activity
TMZ1T_RS04030	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TMZ1T_RS04060	COG1965	Belongs to the frataxin family
TMZ1T_RS04095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TMZ1T_RS04100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TMZ1T_RS04105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TMZ1T_RS04110	COG0070	glutamate synthase
TMZ1T_RS04110	COG0067	glutamate synthase
TMZ1T_RS04110	COG0069	glutamate synthase activity
TMZ1T_RS04120	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TMZ1T_RS04170	COG2814	Major facilitator Superfamily
TMZ1T_RS04175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TMZ1T_RS04225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMZ1T_RS04230	COG1702	phosphate starvation-inducible protein PhoH
TMZ1T_RS04235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TMZ1T_RS04240	COG4535	Mg2 and Co2 transporter CorC
TMZ1T_RS04245	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TMZ1T_RS04250	COG0752	glycyl-tRNA synthetase alpha subunit
TMZ1T_RS04255	COG0751	glycine-tRNA ligase activity
TMZ1T_RS04260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TMZ1T_RS04265	COG0204	Acyl-transferase
TMZ1T_RS04270	COG2154	pterin-4-alpha-carbinolamine dehydratase
TMZ1T_RS04285	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TMZ1T_RS04325	COG1459	type II secretion system
TMZ1T_RS04335	COG1450	Type ii and iii secretion system protein
TMZ1T_RS04340	COG1127	ABC transporter
TMZ1T_RS04345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TMZ1T_RS04350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TMZ1T_RS04370	COG1131	(ABC) transporter
TMZ1T_RS04375	COG0842	Transport permease protein
TMZ1T_RS04380	COG0271	Belongs to the BolA IbaG family
TMZ1T_RS04385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TMZ1T_RS04390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TMZ1T_RS04395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TMZ1T_RS04400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TMZ1T_RS04410	COG3842	ATPase activity
TMZ1T_RS04415	COG1176	ABC-type spermidine putrescine transport system, permease component I
TMZ1T_RS04420	COG1177	transmembrane transport
TMZ1T_RS04425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TMZ1T_RS04430	COG0131	Imidazoleglycerol-phosphate dehydratase
TMZ1T_RS04435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TMZ1T_RS04440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TMZ1T_RS04445	COG0107	imidazoleglycerol-phosphate synthase activity
TMZ1T_RS04450	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TMZ1T_RS04455	COG0140	phosphoribosyl-ATP diphosphatase activity
TMZ1T_RS04465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TMZ1T_RS04470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TMZ1T_RS04480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TMZ1T_RS04485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TMZ1T_RS04495	COG0045	succinate-CoA ligase (ADP-forming) activity
TMZ1T_RS04500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TMZ1T_RS04515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TMZ1T_RS04520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TMZ1T_RS04525	COG0546	phosphoglycolate phosphatase activity
TMZ1T_RS04595	COG0084	hydrolase, TatD family'
TMZ1T_RS04630	COG2003	Belongs to the UPF0758 family
TMZ1T_RS04690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TMZ1T_RS04705	COG0326	Molecular chaperone. Has ATPase activity
TMZ1T_RS04805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TMZ1T_RS04810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TMZ1T_RS04815	COG0519	Catalyzes the synthesis of GMP from XMP
TMZ1T_RS04815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TMZ1T_RS04825	COG3135	benzoate transporter
TMZ1T_RS04850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TMZ1T_RS04910	COG0583	DNA-binding transcription factor activity
TMZ1T_RS04945	COG1611	Belongs to the LOG family
TMZ1T_RS04980	COG0842	Transport permease protein
TMZ1T_RS04985	COG0842	Transport permease protein
TMZ1T_RS04990	COG1131	(ABC) transporter
TMZ1T_RS04995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMZ1T_RS05005	COG1309	transcriptional regulator
TMZ1T_RS05020	COG1028	Short-chain dehydrogenase reductase Sdr
TMZ1T_RS05025	COG0583	DNA-binding transcription factor activity
TMZ1T_RS05035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TMZ1T_RS05040	COG0134	indole-3-glycerol-phosphate synthase activity
TMZ1T_RS05050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TMZ1T_RS05060	COG1522	sequence-specific DNA binding
TMZ1T_RS05065	COG0733	neurotransmitter:sodium symporter activity
TMZ1T_RS05085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TMZ1T_RS05085	COG1565	acr, cog1565
TMZ1T_RS05090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TMZ1T_RS05095	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
TMZ1T_RS05125	COG0109	protoheme IX farnesyltransferase activity
TMZ1T_RS05130	COG0514	ATP-dependent DNA helicase (RecQ)
TMZ1T_RS05155	COG1469	GTP cyclohydrolase I activity
TMZ1T_RS05170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TMZ1T_RS05190	COG0300	oxidoreductase activity
TMZ1T_RS05200	COG1999	signal sequence binding
TMZ1T_RS05315	COG3023	N-Acetylmuramoyl-L-alanine amidase
TMZ1T_RS05325	COG0436	Aminotransferase
TMZ1T_RS05340	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TMZ1T_RS05345	COG0281	malic enzyme
TMZ1T_RS05345	COG0280	phosphate acetyltransferase
TMZ1T_RS05355	COG1686	Belongs to the peptidase S11 family
TMZ1T_RS05375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TMZ1T_RS05375	COG2111	Na H antiporter
TMZ1T_RS05380	COG1006	Multisubunit Na H antiporter MnhC subunit
TMZ1T_RS05385	COG0651	ATP synthesis coupled electron transport
TMZ1T_RS05395	COG2212	antiporter activity
TMZ1T_RS05400	COG1320	monovalent cation:proton antiporter activity
TMZ1T_RS05405	COG1187	pseudouridine synthase activity
TMZ1T_RS05410	COG1320	monovalent cation:proton antiporter activity
TMZ1T_RS05420	COG1863	multisubunit Na H antiporter MnhE subunit
TMZ1T_RS05425	COG0651	ATP synthesis coupled electron transport
TMZ1T_RS05430	COG1006	Multisubunit Na H antiporter MnhC subunit
TMZ1T_RS05435	COG2111	Na H antiporter
TMZ1T_RS05435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TMZ1T_RS05450	COG3206	protein involved in exopolysaccharide biosynthesis
TMZ1T_RS05450	COG0489	protein tyrosine kinase activity
TMZ1T_RS05455	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TMZ1T_RS05460	COG2755	lipolytic protein G-D-S-L family
TMZ1T_RS05460	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TMZ1T_RS05470	COG0438	transferase activity, transferring glycosyl groups
TMZ1T_RS05485	COG0438	transferase activity, transferring glycosyl groups
TMZ1T_RS05490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TMZ1T_RS05510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TMZ1T_RS05530	COG0737	Belongs to the 5'-nucleotidase family
TMZ1T_RS05540	COG2916	Histone family protein nucleoid-structuring protein H-NS
TMZ1T_RS05560	COG0778	Nitroreductase
TMZ1T_RS05565	COG3707	response regulator
TMZ1T_RS05575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TMZ1T_RS05580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TMZ1T_RS05580	COG2146	nitrite reductase [NAD(P)H] activity
TMZ1T_RS05585	COG2814	Major facilitator Superfamily
TMZ1T_RS05590	COG2223	nitrite transmembrane transporter activity
TMZ1T_RS05595	COG0515	serine threonine protein kinase
TMZ1T_RS05600	COG0243	molybdopterin cofactor binding
TMZ1T_RS05605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TMZ1T_RS05615	COG0842	Transport permease protein
TMZ1T_RS05620	COG0842	Transport permease protein
TMZ1T_RS05620	COG1129	ABC transporter
TMZ1T_RS05625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMZ1T_RS05635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TMZ1T_RS05640	COG1127	ABC transporter
TMZ1T_RS05655	COG2326	polyphosphate kinase activity
TMZ1T_RS05675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMZ1T_RS05685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TMZ1T_RS05690	COG0071	Belongs to the small heat shock protein (HSP20) family
TMZ1T_RS05715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TMZ1T_RS05745	COG4536	flavin adenine dinucleotide binding
TMZ1T_RS05755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TMZ1T_RS05785	COG2070	2-Nitropropane dioxygenase
TMZ1T_RS05790	COG0604	alcohol dehydrogenase
TMZ1T_RS05800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMZ1T_RS05825	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TMZ1T_RS05830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TMZ1T_RS05835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TMZ1T_RS05845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TMZ1T_RS05865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TMZ1T_RS05870	COG1466	dna polymerase III delta subunit
TMZ1T_RS05880	COG0495	leucyl-tRNA aminoacylation
TMZ1T_RS05890	COG0210	DNA helicase
TMZ1T_RS05930	COG0482	sulfurtransferase activity
TMZ1T_RS05955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TMZ1T_RS05965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TMZ1T_RS05970	COG0312	modulator of DNA gyrase
TMZ1T_RS05980	COG2204	response regulator
TMZ1T_RS05990	COG2205	protein histidine kinase activity
TMZ1T_RS06000	COG0741	lytic transglycosylase activity
TMZ1T_RS06005	COG0442	prolyl-tRNA aminoacylation
TMZ1T_RS06010	COG0494	nUDIX hydrolase
TMZ1T_RS06020	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TMZ1T_RS06025	COG1765	OsmC-like protein
TMZ1T_RS06030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TMZ1T_RS06035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TMZ1T_RS06040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TMZ1T_RS06045	COG0316	Belongs to the HesB IscA family
TMZ1T_RS06055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TMZ1T_RS06060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TMZ1T_RS06080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TMZ1T_RS06085	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TMZ1T_RS06090	COG2205	protein histidine kinase activity
TMZ1T_RS06110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TMZ1T_RS06115	COG0542	response to heat
TMZ1T_RS06120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TMZ1T_RS06125	COG1278	Cold shock
TMZ1T_RS06130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TMZ1T_RS06135	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TMZ1T_RS06140	COG2003	Belongs to the UPF0758 family
TMZ1T_RS06145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TMZ1T_RS06150	COG0756	dUTP diphosphatase activity
TMZ1T_RS06170	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
TMZ1T_RS06175	COG0538	isocitrate dehydrogenase activity
TMZ1T_RS06185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TMZ1T_RS06200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TMZ1T_RS06210	COG1346	cytolysis
TMZ1T_RS06225	COG0697	spore germination
TMZ1T_RS06230	COG0730	response to heat
TMZ1T_RS06250	COG2217	Heavy metal translocating P-type atpase
TMZ1T_RS06260	COG3278	Belongs to the heme-copper respiratory oxidase family
TMZ1T_RS06295	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TMZ1T_RS06310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TMZ1T_RS06315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TMZ1T_RS06330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TMZ1T_RS06340	COG0469	pyruvate kinase activity
TMZ1T_RS06355	COG2084	Dehydrogenase
TMZ1T_RS06360	COG3622	Belongs to the hyi family
TMZ1T_RS06365	COG3960	tartronate-semialdehyde synthase activity
TMZ1T_RS06370	COG0583	DNA-binding transcription factor activity
TMZ1T_RS06375	COG0583	DNA-binding transcription factor activity
TMZ1T_RS06380	COG1473	amidohydrolase
TMZ1T_RS06400	COG1473	amidohydrolase
TMZ1T_RS06405	COG2233	PERMEase
TMZ1T_RS06415	COG0697	spore germination
TMZ1T_RS06430	COG3851	Histidine kinase
TMZ1T_RS06435	COG4251	negative regulation of phosphorylation
TMZ1T_RS06440	COG0840	transmembrane signaling receptor activity
TMZ1T_RS06460	COG0840	transmembrane signaling receptor activity
TMZ1T_RS06465	COG0835	chemotaxis
TMZ1T_RS06475	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TMZ1T_RS06480	COG2201	protein-glutamate methylesterase activity
TMZ1T_RS06495	COG3447	MASE1 domain protein
TMZ1T_RS06495	COG5001	Diguanylate cyclase
TMZ1T_RS06495	COG5002	protein histidine kinase activity
TMZ1T_RS06505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TMZ1T_RS06515	COG3706	GGDEF domain
TMZ1T_RS06525	COG1131	(ABC) transporter
TMZ1T_RS06530	COG0842	Transport permease protein
TMZ1T_RS06535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TMZ1T_RS06540	COG0583	DNA-binding transcription factor activity
TMZ1T_RS06550	COG0402	S-adenosylhomocysteine deaminase activity
TMZ1T_RS06565	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TMZ1T_RS06575	COG2233	PERMEase
TMZ1T_RS06580	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
TMZ1T_RS06585	COG4266	Belongs to the allantoicase family
TMZ1T_RS06595	COG3648	Uricase
TMZ1T_RS06595	COG3195	allantoin biosynthetic process
TMZ1T_RS06620	COG0625	glutathione transferase activity
TMZ1T_RS06650	COG1079	Belongs to the binding-protein-dependent transport system permease family
TMZ1T_RS06655	COG4603	Belongs to the binding-protein-dependent transport system permease family
TMZ1T_RS06660	COG3845	ABC transporter
TMZ1T_RS06685	COG1230	cation diffusion facilitator family transporter
TMZ1T_RS06735	COG0840	transmembrane signaling receptor activity
TMZ1T_RS06740	COG0326	Molecular chaperone. Has ATPase activity
TMZ1T_RS06750	COG1278	Cold shock
TMZ1T_RS06805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TMZ1T_RS06810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TMZ1T_RS06825	COG2151	metal-sulfur cluster biosynthetic enzyme
TMZ1T_RS06855	COG0471	metal ion transport
TMZ1T_RS06855	COG3273	potassium ion transport
TMZ1T_RS06860	COG1218	3'(2'),5'-bisphosphate nucleotidase
TMZ1T_RS06865	COG0175	sulfate reduction
TMZ1T_RS06875	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TMZ1T_RS06880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TMZ1T_RS06885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TMZ1T_RS06890	COG0723	plastoquinol--plastocyanin reductase activity
TMZ1T_RS06895	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TMZ1T_RS06900	COG2857	Cytochrome c1
TMZ1T_RS06905	COG0625	glutathione transferase activity
TMZ1T_RS06910	COG2969	positive regulation of protein catabolic process
TMZ1T_RS06915	COG2703	oxygen carrier activity
TMZ1T_RS06920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMZ1T_RS06925	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TMZ1T_RS06935	COG0459	protein refolding
TMZ1T_RS06940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMZ1T_RS06945	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TMZ1T_RS06950	COG0508	dehydrogenase complex catalyzes the overall conversion of
TMZ1T_RS06950	COG0022	dehydrogenase e1 component
TMZ1T_RS06960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TMZ1T_RS06965	COG1067	ATP-dependent peptidase activity
TMZ1T_RS06975	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TMZ1T_RS06980	COG0459	protein refolding
TMZ1T_RS06990	COG0642	Histidine kinase
TMZ1T_RS07000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TMZ1T_RS07005	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TMZ1T_RS07010	COG2890	protein-(glutamine-N5) methyltransferase activity
TMZ1T_RS07015	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TMZ1T_RS07040	COG3001	Fructosamine kinase
TMZ1T_RS07045	COG0515	serine threonine protein kinase
TMZ1T_RS07045	COG2815	serine threonine protein kinase
TMZ1T_RS07050	COG0165	Argininosuccinate lyase
TMZ1T_RS07055	COG3275	phosphorelay sensor kinase activity
TMZ1T_RS07065	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TMZ1T_RS07070	COG0181	hydroxymethylbilane synthase activity
TMZ1T_RS07080	COG2959	enzyme of heme biosynthesis
TMZ1T_RS07090	COG0408	coproporphyrinogen oxidase activity
TMZ1T_RS07095	COG0151	Belongs to the GarS family
TMZ1T_RS07100	COG0138	bifunctional purine biosynthesis protein purh
TMZ1T_RS07105	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
TMZ1T_RS07125	COG2011	ABC-type metal ion transport system permease component
TMZ1T_RS07135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TMZ1T_RS07140	COG0006	proline dipeptidase activity
TMZ1T_RS07155	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TMZ1T_RS07160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TMZ1T_RS07165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TMZ1T_RS07170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TMZ1T_RS07180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TMZ1T_RS07205	COG4191	Histidine kinase
TMZ1T_RS07250	COG1752	Esterase of the alpha-beta hydrolase superfamily
TMZ1T_RS07255	COG0668	transmembrane transport
TMZ1T_RS07275	COG3119	arylsulfatase activity
TMZ1T_RS07280	COG0641	radical SAM
TMZ1T_RS07300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TMZ1T_RS07310	COG3485	protocatechuate 3,4-dioxygenase
TMZ1T_RS07345	COG1053	succinate dehydrogenase
TMZ1T_RS07350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TMZ1T_RS07355	COG0126	phosphoglycerate kinase activity
TMZ1T_RS07360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TMZ1T_RS07365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TMZ1T_RS07375	COG0483	inositol monophosphate 1-phosphatase activity
TMZ1T_RS07380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TMZ1T_RS07385	COG1042	CoA-binding domain protein
TMZ1T_RS07385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TMZ1T_RS07385	COG0045	succinate-CoA ligase (ADP-forming) activity
TMZ1T_RS07390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TMZ1T_RS07395	COG2151	metal-sulfur cluster biosynthetic enzyme
TMZ1T_RS07400	COG3396	Phenylacetate-CoA oxygenase
TMZ1T_RS07405	COG3460	Phenylacetate-CoA oxygenase
TMZ1T_RS07410	COG3396	Phenylacetate-CoA oxygenase
TMZ1T_RS07420	COG0183	Belongs to the thiolase family
TMZ1T_RS07430	COG2050	protein possibly involved in aromatic compounds catabolism
TMZ1T_RS07435	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMZ1T_RS07440	COG1024	Enoyl-CoA hydratase
TMZ1T_RS07455	COG3327	negative regulation of DNA-templated transcription, initiation
TMZ1T_RS07495	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TMZ1T_RS07495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TMZ1T_RS07505	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TMZ1T_RS07515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TMZ1T_RS07520	COG0303	'Molybdopterin
TMZ1T_RS07525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TMZ1T_RS07530	COG1333	cytochrome c biogenesis protein
TMZ1T_RS07540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TMZ1T_RS07560	COG2226	methyltransferase
TMZ1T_RS07565	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TMZ1T_RS07575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TMZ1T_RS07580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TMZ1T_RS07590	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TMZ1T_RS07600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TMZ1T_RS07605	COG0640	Transcriptional regulator
TMZ1T_RS07610	COG4942	peptidase
TMZ1T_RS07615	COG0793	Belongs to the peptidase S41A family
TMZ1T_RS07625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TMZ1T_RS07630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMZ1T_RS07630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMZ1T_RS07635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TMZ1T_RS07640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TMZ1T_RS07655	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMZ1T_RS07675	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TMZ1T_RS07680	COG0312	modulator of DNA gyrase
TMZ1T_RS07685	COG3028	Belongs to the UPF0307 family
TMZ1T_RS07690	COG0521	Mo-molybdopterin cofactor biosynthetic process
TMZ1T_RS07700	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TMZ1T_RS07705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TMZ1T_RS07710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TMZ1T_RS07715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TMZ1T_RS07720	COG1132	(ABC) transporter
TMZ1T_RS07725	COG2096	Adenosyltransferase
TMZ1T_RS07740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TMZ1T_RS07755	COG0545	Peptidyl-prolyl cis-trans isomerase
TMZ1T_RS07765	COG0861	Integral membrane protein TerC family
TMZ1T_RS07770	COG1253	flavin adenine dinucleotide binding
TMZ1T_RS07775	COG0628	permease
TMZ1T_RS07780	COG1192	Involved in chromosome partitioning
TMZ1T_RS07785	COG0281	malic enzyme
TMZ1T_RS07785	COG0280	phosphate acetyltransferase
TMZ1T_RS07805	COG1254	Belongs to the acylphosphatase family
TMZ1T_RS07810	COG0659	secondary active sulfate transmembrane transporter activity
TMZ1T_RS07815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TMZ1T_RS07815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TMZ1T_RS07825	COG0489	protein tyrosine kinase activity
TMZ1T_RS07830	COG0717	Belongs to the dCTP deaminase family
TMZ1T_RS07845	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TMZ1T_RS07885	COG2030	dehydratase
TMZ1T_RS07890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TMZ1T_RS07895	COG3852	Histidine kinase
TMZ1T_RS07900	COG2204	response regulator
TMZ1T_RS07910	COG1196	nuclear chromosome segregation
TMZ1T_RS07910	COG0741	lytic transglycosylase activity
TMZ1T_RS07910	COG0739	heme binding
TMZ1T_RS07935	COG0488	(ABC) transporter
TMZ1T_RS07950	COG1704	LemA family
TMZ1T_RS07965	COG0604	alcohol dehydrogenase
TMZ1T_RS07975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMZ1T_RS08015	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TMZ1T_RS08050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TMZ1T_RS08055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TMZ1T_RS08060	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TMZ1T_RS08065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TMZ1T_RS08085	COG0277	FAD linked oxidase domain protein
TMZ1T_RS08090	COG0277	FAD linked oxidase domain protein
TMZ1T_RS08095	COG0247	lactate metabolic process
TMZ1T_RS08100	COG0631	protein serine/threonine phosphatase activity
TMZ1T_RS08110	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TMZ1T_RS08125	COG3300	MHYT domain
TMZ1T_RS08125	COG5001	Diguanylate cyclase
TMZ1T_RS08130	COG0513	Belongs to the DEAD box helicase family
TMZ1T_RS08135	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TMZ1T_RS08140	COG0667	Aldo Keto reductase
TMZ1T_RS08155	COG0142	geranyltranstransferase activity
TMZ1T_RS08165	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TMZ1T_RS08170	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TMZ1T_RS08180	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TMZ1T_RS08180	COG0456	acetyltransferase
TMZ1T_RS08195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMZ1T_RS08205	COG2902	Dehydrogenase
TMZ1T_RS08210	COG0504	CTP synthase activity
TMZ1T_RS08215	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TMZ1T_RS08220	COG0148	phosphopyruvate hydratase activity
TMZ1T_RS08225	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TMZ1T_RS08230	COG0791	NLP P60 protein
TMZ1T_RS08245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TMZ1T_RS08255	COG0306	phosphate transporter
TMZ1T_RS08265	COG0302	gtp cyclohydrolase
TMZ1T_RS08275	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TMZ1T_RS08290	COG4681	YaeQ
TMZ1T_RS08295	COG0596	Alpha beta hydrolase
TMZ1T_RS08310	COG1278	Cold shock
TMZ1T_RS08320	COG0613	PHP domain protein
TMZ1T_RS08325	COG0009	L-threonylcarbamoyladenylate synthase
TMZ1T_RS08330	COG1994	Peptidase M50
TMZ1T_RS08335	COG0180	Tryptophanyl-tRNA synthetase
TMZ1T_RS08340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TMZ1T_RS08345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TMZ1T_RS08350	COG1187	pseudouridine synthase activity
TMZ1T_RS08355	COG0779	Required for maturation of 30S ribosomal subunits
TMZ1T_RS08360	COG0195	Participates in both transcription termination and antitermination
TMZ1T_RS08360	COG2251	uridine kinase activity
TMZ1T_RS08365	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TMZ1T_RS08370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TMZ1T_RS08375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TMZ1T_RS08380	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TMZ1T_RS08385	COG1185	polyribonucleotide nucleotidyltransferase activity
TMZ1T_RS08390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TMZ1T_RS08400	COG2032	superoxide dismutase activity
TMZ1T_RS08410	COG0584	glycerophosphoryl diester phosphodiesterase
TMZ1T_RS08425	COG2951	lytic endotransglycosylase activity
TMZ1T_RS08430	COG2186	Transcriptional regulator
TMZ1T_RS08460	COG1690	Belongs to the RtcB family
TMZ1T_RS08465	COG1620	l-lactate permease
TMZ1T_RS08470	COG0247	lactate metabolic process
TMZ1T_RS08475	COG1139	Iron-sulfur cluster binding protein
TMZ1T_RS08485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TMZ1T_RS08485	COG1042	CoA-binding domain protein
TMZ1T_RS08485	COG0045	succinate-CoA ligase (ADP-forming) activity
TMZ1T_RS08490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TMZ1T_RS08500	COG0402	S-adenosylhomocysteine deaminase activity
TMZ1T_RS08505	COG2815	serine threonine protein kinase
TMZ1T_RS08505	COG0515	serine threonine protein kinase
TMZ1T_RS08510	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TMZ1T_RS08515	COG1420	regulation of RNA biosynthetic process
TMZ1T_RS08520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TMZ1T_RS08525	COG0497	DNA recombination
TMZ1T_RS08530	COG0735	belongs to the Fur family
TMZ1T_RS08535	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TMZ1T_RS08540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TMZ1T_RS08550	COG0505	Belongs to the CarA family
TMZ1T_RS08555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TMZ1T_RS08560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TMZ1T_RS08565	COG1534	Rna-binding protein
TMZ1T_RS08570	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TMZ1T_RS08575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TMZ1T_RS08580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TMZ1T_RS08585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TMZ1T_RS08590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TMZ1T_RS08595	COG0149	triose-phosphate isomerase activity
TMZ1T_RS08610	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMZ1T_RS08615	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMZ1T_RS08620	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMZ1T_RS08625	COG0649	NAD binding
TMZ1T_RS08630	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TMZ1T_RS08640	COG1034	ATP synthesis coupled electron transport
TMZ1T_RS08645	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TMZ1T_RS08650	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMZ1T_RS08660	COG0713	ATP synthesis coupled electron transport
TMZ1T_RS08675	COG1007	ATP synthesis coupled electron transport
TMZ1T_RS08695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TMZ1T_RS08695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TMZ1T_RS08705	COG2840	Smr protein MutS2
TMZ1T_RS08710	COG0492	ferredoxin-NADP+ reductase activity
TMZ1T_RS08720	COG1674	ftsk spoiiie
TMZ1T_RS08725	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TMZ1T_RS08730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TMZ1T_RS08740	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TMZ1T_RS08745	COG0484	heat shock protein binding
TMZ1T_RS08770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TMZ1T_RS08775	COG1469	GTP cyclohydrolase I activity
TMZ1T_RS08780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TMZ1T_RS08785	COG0142	geranyltranstransferase activity
TMZ1T_RS08790	COG1722	exodeoxyribonuclease VII activity
TMZ1T_RS08800	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TMZ1T_RS08805	COG1047	Peptidyl-prolyl cis-trans
TMZ1T_RS08810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TMZ1T_RS08815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TMZ1T_RS08820	COG0196	riboflavin kinase activity
TMZ1T_RS08825	COG0860	N-Acetylmuramoyl-L-alanine amidase
TMZ1T_RS08830	COG0802	atpase or kinase
TMZ1T_RS08840	COG2900	Belongs to the SlyX family
TMZ1T_RS08855	COG3033	Beta-eliminating lyase
TMZ1T_RS08860	COG3045	CreA protein
TMZ1T_RS08875	COG0826	peptidase U32
TMZ1T_RS08890	COG2133	pyrroloquinoline quinone binding
TMZ1T_RS08895	COG0515	serine threonine protein kinase
TMZ1T_RS08905	COG3108	Peptidase M15
TMZ1T_RS08910	COG2989	Protein conserved in bacteria
TMZ1T_RS08930	COG4771	TonB-dependent receptor
TMZ1T_RS08985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMZ1T_RS08990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TMZ1T_RS08995	COG2841	Protein conserved in bacteria
TMZ1T_RS09005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TMZ1T_RS09020	COG1238	metal cluster binding
TMZ1T_RS09025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TMZ1T_RS09030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TMZ1T_RS09040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TMZ1T_RS09040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TMZ1T_RS09045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TMZ1T_RS09055	COG0720	synthase
TMZ1T_RS09070	COG0527	aspartate kinase activity
TMZ1T_RS09085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TMZ1T_RS09085	COG1199	ATP-dependent helicase activity
TMZ1T_RS09095	COG0443	Heat shock 70 kDa protein
TMZ1T_RS09110	COG1012	belongs to the aldehyde dehydrogenase family
TMZ1T_RS09130	COG2204	response regulator
TMZ1T_RS09145	COG5001	Diguanylate cyclase
TMZ1T_RS09145	COG1716	ATPase activity
TMZ1T_RS09150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TMZ1T_RS09155	COG1074	ATP-dependent DNA helicase activity
TMZ1T_RS09160	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
TMZ1T_RS09165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TMZ1T_RS09180	COG0798	PFAM Bile acid sodium symporter
TMZ1T_RS09185	COG1595	DNA-templated transcription, initiation
TMZ1T_RS09200	COG1064	alcohol dehydrogenase
TMZ1T_RS09210	COG2353	YceI-like domain
TMZ1T_RS09220	COG3038	cytochrome b561
TMZ1T_RS09330	COG0583	DNA-binding transcription factor activity
TMZ1T_RS09335	COG3384	dioxygenase
TMZ1T_RS09340	COG0400	carboxylic ester hydrolase activity
TMZ1T_RS09390	COG0822	iron-sulfur transferase activity
TMZ1T_RS09395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TMZ1T_RS09400	COG0719	Fe-S assembly protein
TMZ1T_RS09405	COG0396	ATPase activity
TMZ1T_RS09410	COG0719	Fe-S assembly protein
TMZ1T_RS09430	COG2363	Small membrane protein
TMZ1T_RS09435	COG0625	glutathione transferase activity
TMZ1T_RS09440	COG1490	D-aminoacyl-tRNA deacylase activity
TMZ1T_RS09470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TMZ1T_RS09490	COG1309	transcriptional regulator
TMZ1T_RS09505	COG1136	(ABC) transporter
TMZ1T_RS09505	COG0577	efflux transmembrane transporter activity
TMZ1T_RS09530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TMZ1T_RS09540	COG1858	cytochrome C peroxidase
TMZ1T_RS09560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TMZ1T_RS09570	COG5002	protein histidine kinase activity
TMZ1T_RS09575	COG2194	sulfuric ester hydrolase activity
TMZ1T_RS09645	COG2814	Major facilitator Superfamily
TMZ1T_RS09660	COG0587	DNA-directed DNA polymerase activity
TMZ1T_RS09670	COG4120	Belongs to the binding-protein-dependent transport system permease family
TMZ1T_RS09675	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TMZ1T_RS09680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TMZ1T_RS09690	COG2197	response regulator
TMZ1T_RS09700	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TMZ1T_RS09700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMZ1T_RS09705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TMZ1T_RS09715	COG1196	nuclear chromosome segregation
TMZ1T_RS09720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TMZ1T_RS09735	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TMZ1T_RS09750	COG0022	dehydrogenase e1 component
TMZ1T_RS09780	COG1181	Belongs to the D-alanine--D-alanine ligase family
TMZ1T_RS09830	COG2226	methyltransferase
TMZ1T_RS09840	COG1032	radical SAM domain protein
TMZ1T_RS09855	COG1136	(ABC) transporter
TMZ1T_RS09880	COG1162	GTPase activity
TMZ1T_RS09885	COG0501	Belongs to the peptidase M48B family
TMZ1T_RS09890	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TMZ1T_RS09900	COG0254	rRNA binding
TMZ1T_RS09905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TMZ1T_RS09910	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TMZ1T_RS09915	COG3318	Belongs to the UPF0149 family
TMZ1T_RS09915	COG3012	SEC-C Motif Domain Protein
TMZ1T_RS09920	COG0727	PFAM Uncharacterised protein family (UPF0153)
TMZ1T_RS09945	COG3012	SEC-C Motif Domain Protein
TMZ1T_RS09950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TMZ1T_RS10025	COG0723	plastoquinol--plastocyanin reductase activity
TMZ1T_RS10030	COG1242	4 iron, 4 sulfur cluster binding
TMZ1T_RS10075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TMZ1T_RS10110	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TMZ1T_RS10120	COG0850	regulation of cytokinetic process
TMZ1T_RS10125	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TMZ1T_RS10130	COG1393	Belongs to the ArsC family
TMZ1T_RS10135	COG2183	response to ionizing radiation
TMZ1T_RS10145	COG0045	succinate-CoA ligase (ADP-forming) activity
TMZ1T_RS10145	COG1042	CoA-binding domain protein
TMZ1T_RS10145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TMZ1T_RS10150	COG2205	protein histidine kinase activity
TMZ1T_RS10150	COG2202	Pas domain
TMZ1T_RS10155	COG0297	glycogen (starch) synthase activity
TMZ1T_RS10160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TMZ1T_RS10170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TMZ1T_RS10175	COG0837	glucose binding
TMZ1T_RS10180	COG0366	Alpha amylase catalytic
TMZ1T_RS10185	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TMZ1T_RS10190	COG1879	ABC-type sugar transport system periplasmic component
TMZ1T_RS10225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TMZ1T_RS10235	COG0583	DNA-binding transcription factor activity
TMZ1T_RS10265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TMZ1T_RS10285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMZ1T_RS10305	COG4569	acetaldehyde dehydrogenase (acetylating) activity
TMZ1T_RS10310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMZ1T_RS10355	COG4584	PFAM Integrase catalytic
TMZ1T_RS10415	COG5002	protein histidine kinase activity
TMZ1T_RS10425	COG0789	Transcriptional regulator
TMZ1T_RS10455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TMZ1T_RS10515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TMZ1T_RS10515	COG1199	ATP-dependent helicase activity
TMZ1T_RS10540	COG1690	Belongs to the RtcB family
TMZ1T_RS10550	COG1418	mRNA catabolic process
TMZ1T_RS10555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TMZ1T_RS10570	COG0662	Cupin 2, conserved barrel domain protein
TMZ1T_RS10570	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TMZ1T_RS10615	COG3041	Addiction module toxin RelE StbE family
TMZ1T_RS10620	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TMZ1T_RS10650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TMZ1T_RS10665	COG1562	ergosterol biosynthetic process
TMZ1T_RS10675	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TMZ1T_RS10680	COG2866	Carboxypeptidase
TMZ1T_RS10685	COG3022	response to hydroperoxide
TMZ1T_RS10695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TMZ1T_RS10700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TMZ1T_RS10705	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TMZ1T_RS10710	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TMZ1T_RS10715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TMZ1T_RS10720	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TMZ1T_RS10740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TMZ1T_RS10745	COG0575	Belongs to the CDS family
TMZ1T_RS10750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TMZ1T_RS10755	COG0233	cytoplasmic translational termination
TMZ1T_RS10760	COG0528	UMP kinase activity
TMZ1T_RS10765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TMZ1T_RS10770	COG0052	Belongs to the universal ribosomal protein uS2 family
TMZ1T_RS10780	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TMZ1T_RS10785	COG2862	Uncharacterized protein family, UPF0114
TMZ1T_RS10790	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TMZ1T_RS10815	COG1858	cytochrome C peroxidase
TMZ1T_RS10820	COG1858	cytochrome C peroxidase
TMZ1T_RS10825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TMZ1T_RS10830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TMZ1T_RS10840	COG1196	nuclear chromosome segregation
TMZ1T_RS10850	COG2171	N-acyltransferase activity
TMZ1T_RS10860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TMZ1T_RS10870	COG2201	protein-glutamate methylesterase activity
TMZ1T_RS10885	COG0443	Heat shock 70 kDa protein
TMZ1T_RS10890	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TMZ1T_RS10900	COG0822	iron-sulfur transferase activity
TMZ1T_RS10905	COG1104	cysteine desulfurase activity
TMZ1T_RS10910	COG1104	cysteine desulfurase activity
TMZ1T_RS10915	COG1959	2 iron, 2 sulfur cluster binding
TMZ1T_RS10920	COG1045	serine acetyltransferase
TMZ1T_RS10925	COG3228	Belongs to the MtfA family
TMZ1T_RS10945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TMZ1T_RS10950	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TMZ1T_RS10955	COG1355	regulation of microtubule-based process
TMZ1T_RS10980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TMZ1T_RS10985	COG0598	Magnesium transport protein CorA
TMZ1T_RS10995	COG0348	domain, Protein
TMZ1T_RS11010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TMZ1T_RS11015	COG2818	Glycosylase
TMZ1T_RS11050	COG1518	maintenance of DNA repeat elements
TMZ1T_RS11060	COG0300	oxidoreductase activity
TMZ1T_RS11075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TMZ1T_RS11080	COG0560	Phosphoserine phosphatase
TMZ1T_RS11085	COG4181	ATPase activity
TMZ1T_RS11095	COG0709	Synthesizes selenophosphate from selenide and ATP
TMZ1T_RS11100	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
TMZ1T_RS11110	COG0058	SHG alpha-glucan phosphorylase activity
TMZ1T_RS11115	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TMZ1T_RS11120	COG3383	formate dehydrogenase (NAD+) activity
TMZ1T_RS11125	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
TMZ1T_RS11130	COG3259	Nickel-dependent hydrogenase
TMZ1T_RS11145	COG0583	DNA-binding transcription factor activity
TMZ1T_RS11150	COG0477	Major facilitator Superfamily
TMZ1T_RS11185	COG2917	probably involved in intracellular septation
TMZ1T_RS11190	COG2350	Protein conserved in bacteria
TMZ1T_RS11200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TMZ1T_RS11205	COG1960	acyl-CoA dehydrogenase activity
TMZ1T_RS11235	COG0084	hydrolase, TatD family'
TMZ1T_RS11240	COG1024	Enoyl-CoA hydratase
TMZ1T_RS11245	COG3706	GGDEF domain
TMZ1T_RS11260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TMZ1T_RS11265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TMZ1T_RS11270	COG0248	Ppx GppA phosphatase
TMZ1T_RS11275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TMZ1T_RS11280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TMZ1T_RS11290	COG0483	inositol monophosphate 1-phosphatase activity
TMZ1T_RS11300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TMZ1T_RS11315	COG0516	GMP reductase activity
TMZ1T_RS11315	COG0517	IMP dehydrogenase activity
TMZ1T_RS11325	COG0328	RNA-DNA hybrid ribonuclease activity
TMZ1T_RS11330	COG2226	methyltransferase
TMZ1T_RS11335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TMZ1T_RS11340	COG0741	lytic transglycosylase activity
TMZ1T_RS11340	COG1388	LysM domain
TMZ1T_RS11350	COG1047	Peptidyl-prolyl cis-trans
TMZ1T_RS11365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TMZ1T_RS11420	COG0322	excinuclease ABC activity
TMZ1T_RS11425	COG1472	Belongs to the glycosyl hydrolase 3 family
TMZ1T_RS11430	COG0736	holo-[acyl-carrier-protein] synthase activity
TMZ1T_RS11435	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TMZ1T_RS11440	COG1381	Involved in DNA repair and RecF pathway recombination
TMZ1T_RS11445	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TMZ1T_RS11450	COG0571	ribonuclease III activity
TMZ1T_RS11460	COG0681	Belongs to the peptidase S26 family
TMZ1T_RS11465	COG0481	GTPase activity
TMZ1T_RS11475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TMZ1T_RS11500	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TMZ1T_RS11515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TMZ1T_RS11530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TMZ1T_RS11535	COG0416	fatty acid biosynthetic process
TMZ1T_RS11540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TMZ1T_RS11545	COG1399	metal-binding, possibly nucleic acid-binding protein
TMZ1T_RS11550	COG0424	maF-like protein
TMZ1T_RS11570	COG1530	ribonuclease E activity
TMZ1T_RS11575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TMZ1T_RS11580	COG0556	nucleotide-excision repair
TMZ1T_RS11600	COG1320	monovalent cation:proton antiporter activity
TMZ1T_RS11605	COG2212	antiporter activity
TMZ1T_RS11610	COG1863	multisubunit Na H antiporter MnhE subunit
TMZ1T_RS11615	COG0651	ATP synthesis coupled electron transport
TMZ1T_RS11620	COG1006	Multisubunit Na H antiporter MnhC subunit
TMZ1T_RS11625	COG2111	Na H antiporter
TMZ1T_RS11625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TMZ1T_RS11630	COG3040	lipid binding
TMZ1T_RS11635	COG3647	Membrane
TMZ1T_RS11645	COG1067	ATP-dependent peptidase activity
TMZ1T_RS11650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TMZ1T_RS11675	COG0297	glycogen (starch) synthase activity
TMZ1T_RS11695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMZ1T_RS11695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMZ1T_RS11725	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TMZ1T_RS11730	COG1473	amidohydrolase
TMZ1T_RS11735	COG0513	Belongs to the DEAD box helicase family
TMZ1T_RS11805	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TMZ1T_RS11810	COG1278	Cold shock
TMZ1T_RS11830	COG1902	pentaerythritol trinitrate reductase activity
TMZ1T_RS11840	COG1960	acyl-CoA dehydrogenase activity
TMZ1T_RS11855	COG0183	Belongs to the thiolase family
TMZ1T_RS11860	COG1024	Enoyl-CoA hydratase
TMZ1T_RS11865	COG0318	PFAM AMP-dependent synthetase and ligase
TMZ1T_RS11875	COG1309	transcriptional regulator
TMZ1T_RS11885	COG0446	pyridine nucleotide-disulphide oxidoreductase
TMZ1T_RS11885	COG1902	pentaerythritol trinitrate reductase activity
TMZ1T_RS11890	COG2824	Alkylphosphonate utilization operon protein PhnA
TMZ1T_RS11900	COG0084	hydrolase, TatD family'
TMZ1T_RS11915	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TMZ1T_RS11920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TMZ1T_RS11940	COG1376	ErfK ybiS ycfS ynhG family protein
TMZ1T_RS11950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TMZ1T_RS11960	COG0657	acetylesterase activity
TMZ1T_RS11995	COG1704	LemA family
TMZ1T_RS12015	COG0314	molybdopterin synthase activity
TMZ1T_RS12020	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TMZ1T_RS12025	COG0303	'Molybdopterin
TMZ1T_RS12030	COG1763	Mo-molybdopterin cofactor biosynthetic process
TMZ1T_RS12035	COG1199	ATP-dependent helicase activity
TMZ1T_RS12105	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TMZ1T_RS12110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TMZ1T_RS12115	COG0508	dehydrogenase complex catalyzes the overall conversion of
TMZ1T_RS12120	COG0567	Dehydrogenase, E1 component
TMZ1T_RS12130	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
TMZ1T_RS12135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TMZ1T_RS12140	COG1053	succinate dehydrogenase
TMZ1T_RS12155	COG2188	Transcriptional regulator
TMZ1T_RS12160	COG0039	L-malate dehydrogenase activity
TMZ1T_RS12170	COG0583	DNA-binding transcription factor activity
TMZ1T_RS12175	COG2814	Major facilitator Superfamily
TMZ1T_RS12205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TMZ1T_RS12210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TMZ1T_RS12215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TMZ1T_RS12220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TMZ1T_RS12225	COG0740	serine-type endopeptidase activity
TMZ1T_RS12230	COG0544	peptidyl-prolyl cis-trans isomerase activity
TMZ1T_RS12235	COG2766	serine protein kinase
TMZ1T_RS12240	COG2718	Belongs to the UPF0229 family
TMZ1T_RS12245	COG2719	SpoVR family
TMZ1T_RS12250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TMZ1T_RS12250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TMZ1T_RS12280	COG3360	Dodecin
TMZ1T_RS12285	COG2258	MOSC domain
TMZ1T_RS12295	COG0436	Aminotransferase
TMZ1T_RS12305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TMZ1T_RS12310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TMZ1T_RS12325	COG0791	NLP P60 protein
TMZ1T_RS12335	COG1840	ABC-type Fe3 transport system, periplasmic component
TMZ1T_RS12345	COG1178	ABC-type Fe3 transport system permease component
TMZ1T_RS12350	COG3842	ATPase activity
TMZ1T_RS12355	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TMZ1T_RS12360	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
TMZ1T_RS12365	COG0167	dihydroorotate dehydrogenase activity
TMZ1T_RS12380	COG2010	Cytochrome c
TMZ1T_RS12395	COG1845	cytochrome c oxidase, subunit III
TMZ1T_RS12410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TMZ1T_RS12440	COG0535	radical SAM domain protein
TMZ1T_RS12455	COG1522	sequence-specific DNA binding
TMZ1T_RS12465	COG2010	Cytochrome c
TMZ1T_RS12485	COG2010	Cytochrome c
TMZ1T_RS12490	COG1648	precorrin-2 dehydrogenase activity
TMZ1T_RS12490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TMZ1T_RS12505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TMZ1T_RS12505	COG0519	Catalyzes the synthesis of GMP from XMP
TMZ1T_RS12520	COG2914	Belongs to the UPF0125 (RnfH) family
TMZ1T_RS12530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TMZ1T_RS12545	COG2197	response regulator
TMZ1T_RS12550	COG3850	Histidine kinase
TMZ1T_RS12555	COG2181	nitrate reductase activity
TMZ1T_RS12560	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
TMZ1T_RS12570	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TMZ1T_RS12590	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
TMZ1T_RS12595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMZ1T_RS12600	COG0601	transmembrane transport
TMZ1T_RS12615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TMZ1T_RS12625	COG0542	response to heat
TMZ1T_RS12630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TMZ1T_RS12635	COG5002	protein histidine kinase activity
TMZ1T_RS12635	COG2176	DNA-directed DNA polymerase activity
TMZ1T_RS12640	COG0745	RESPONSE REGULATOR receiver
TMZ1T_RS12645	COG5002	protein histidine kinase activity
TMZ1T_RS12655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMZ1T_RS12675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TMZ1T_RS12685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TMZ1T_RS12690	COG0183	Belongs to the thiolase family
TMZ1T_RS12695	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TMZ1T_RS12750	COG1666	GTP binding
TMZ1T_RS12755	COG3123	guanosine phosphorylase activity
TMZ1T_RS12765	COG0137	argininosuccinate synthase activity
TMZ1T_RS12770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TMZ1T_RS12775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TMZ1T_RS12785	COG0268	Binds directly to 16S ribosomal RNA
TMZ1T_RS12790	COG0728	peptidoglycan biosynthetic process
TMZ1T_RS12795	COG0583	DNA-binding transcription factor activity
TMZ1T_RS12810	COG0386	Belongs to the glutathione peroxidase family
TMZ1T_RS12825	COG0488	(ABC) transporter
TMZ1T_RS12860	COG4964	Belongs to the GSP D family
TMZ1T_RS12900	COG0697	spore germination
TMZ1T_RS12910	COG5433	transposase activity
TMZ1T_RS12940	COG2201	protein-glutamate methylesterase activity
TMZ1T_RS13040	COG3005	denitrification pathway
TMZ1T_RS13070	COG1595	DNA-templated transcription, initiation
TMZ1T_RS13110	COG0033	Phosphoglucomutase
TMZ1T_RS13155	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TMZ1T_RS13160	COG0628	permease
TMZ1T_RS13165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TMZ1T_RS13175	COG0617	tRNA 3'-terminal CCA addition
TMZ1T_RS13190	COG1428	Deoxynucleoside kinase
TMZ1T_RS13195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TMZ1T_RS13200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TMZ1T_RS13205	COG0516	GMP reductase activity
TMZ1T_RS13205	COG0517	IMP dehydrogenase activity
TMZ1T_RS13210	COG0308	aminopeptidase N
TMZ1T_RS13220	COG4651	solute:proton antiporter activity
TMZ1T_RS13220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TMZ1T_RS13230	COG0028	Belongs to the TPP enzyme family
TMZ1T_RS13235	COG0440	acetolactate synthase activity
TMZ1T_RS13240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TMZ1T_RS13245	COG1183	phosphatidylcholine synthase activity
TMZ1T_RS13250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMZ1T_RS13270	COG0228	four-way junction DNA binding
TMZ1T_RS13275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TMZ1T_RS13280	COG0336	Belongs to the RNA methyltransferase TrmD family
TMZ1T_RS13285	COG0335	large ribosomal subunit rRNA binding
TMZ1T_RS13290	COG0795	lipopolysaccharide-transporting ATPase activity
TMZ1T_RS13295	COG0795	lipopolysaccharide-transporting ATPase activity
TMZ1T_RS13300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TMZ1T_RS13315	COG0525	valine-tRNA ligase activity
TMZ1T_RS13320	COG0425	Belongs to the sulfur carrier protein TusA family
TMZ1T_RS13325	COG4783	chaperone-mediated protein folding
TMZ1T_RS13330	COG0315	cyclic pyranopterin monophosphate synthase activity
TMZ1T_RS13375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TMZ1T_RS13400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TMZ1T_RS13405	COG2414	aldehyde ferredoxin oxidoreductase
TMZ1T_RS13415	COG3284	Transcriptional regulator
TMZ1T_RS13465	COG3383	formate dehydrogenase (NAD+) activity
TMZ1T_RS13480	COG4591	ABC-type transport system involved in lipoprotein release permease component
TMZ1T_RS13485	COG1136	(ABC) transporter
TMZ1T_RS13500	COG2205	protein histidine kinase activity
TMZ1T_RS13500	COG2198	Histidine kinase
TMZ1T_RS13500	COG0784	Response regulator, receiver
TMZ1T_RS13505	COG3706	GGDEF domain
TMZ1T_RS13510	COG3437	response regulator, receiver
TMZ1T_RS13525	COG0535	radical SAM domain protein
TMZ1T_RS13535	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TMZ1T_RS13540	COG0167	dihydroorotate dehydrogenase activity
TMZ1T_RS13585	COG1131	(ABC) transporter
TMZ1T_RS13590	COG1116	anion transmembrane transporter activity
TMZ1T_RS13625	COG3963	phosphatidate phosphatase activity
TMZ1T_RS13630	COG2354	Protein conserved in bacteria
TMZ1T_RS13660	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TMZ1T_RS13665	COG4772	TonB-dependent receptor
TMZ1T_RS13670	COG3284	Transcriptional regulator
TMZ1T_RS13680	COG1012	belongs to the aldehyde dehydrogenase family
TMZ1T_RS13690	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TMZ1T_RS13715	COG0028	Belongs to the TPP enzyme family
TMZ1T_RS13740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TMZ1T_RS13755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TMZ1T_RS13765	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TMZ1T_RS13785	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TMZ1T_RS13790	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
TMZ1T_RS13795	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
TMZ1T_RS13800	COG1677	Flagellar hook-basal body complex protein FliE
TMZ1T_RS13815	COG1766	The M ring may be actively involved in energy transduction
TMZ1T_RS13820	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TMZ1T_RS13825	COG5433	transposase activity
TMZ1T_RS13835	COG1157	protein secretion by the type III secretion system
TMZ1T_RS13855	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TMZ1T_RS13890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TMZ1T_RS13900	COG3951	Flagellar rod assembly protein muramidase FlgJ
TMZ1T_RS13900	COG1705	Flagellar rod assembly protein muramidase FlgJ
TMZ1T_RS13905	COG1706	bacterial-type flagellum-dependent cell motility
TMZ1T_RS13910	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TMZ1T_RS13920	COG4787	bacterial-type flagellum-dependent cell motility
TMZ1T_RS13925	COG1749	Flagellar hook protein flgE
TMZ1T_RS13930	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TMZ1T_RS13935	COG1558	bacterial-type flagellum-dependent cell motility
TMZ1T_RS13940	COG1815	bacterial-type flagellum-dependent cell motility
TMZ1T_RS13985	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TMZ1T_RS14010	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TMZ1T_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
TMZ1T_RS14055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TMZ1T_RS14095	COG0674	pyruvate-flavodoxin oxidoreductase activity
TMZ1T_RS14095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TMZ1T_RS14100	COG1013	pyruvate-flavodoxin oxidoreductase activity
TMZ1T_RS14110	COG0517	IMP dehydrogenase activity
TMZ1T_RS14115	COG0243	molybdopterin cofactor binding
TMZ1T_RS14120	COG0437	4 iron, 4 sulfur cluster binding
TMZ1T_RS14255	COG0826	peptidase U32
TMZ1T_RS14265	COG4657	Part of a membrane complex involved in electron transport
TMZ1T_RS14275	COG4656	Part of a membrane complex involved in electron transport
TMZ1T_RS14280	COG4658	electron transport chain
TMZ1T_RS14300	COG0789	Transcriptional regulator
TMZ1T_RS14325	COG0011	TIGRFAM Protein of
TMZ1T_RS14345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TMZ1T_RS14355	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
TMZ1T_RS14360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TMZ1T_RS14365	COG0123	including yeast histone deacetylase and acetoin utilization protein
TMZ1T_RS14370	COG0714	Associated with various cellular activities
TMZ1T_RS14385	COG2951	lytic endotransglycosylase activity
TMZ1T_RS14405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TMZ1T_RS14410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TMZ1T_RS14425	COG0776	regulation of translation
TMZ1T_RS14430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TMZ1T_RS14430	COG0072	phenylalanine-tRNA ligase activity
TMZ1T_RS14435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TMZ1T_RS14440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TMZ1T_RS14445	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TMZ1T_RS14450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TMZ1T_RS14455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TMZ1T_RS14495	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
TMZ1T_RS14505	COG0776	regulation of translation
TMZ1T_RS14515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TMZ1T_RS14520	COG0287	Prephenate dehydrogenase
TMZ1T_RS14525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TMZ1T_RS14545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TMZ1T_RS14550	COG0443	Heat shock 70 kDa protein
TMZ1T_RS14555	COG0484	heat shock protein binding
TMZ1T_RS14565	COG0215	cysteine-tRNA ligase activity
TMZ1T_RS14570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TMZ1T_RS14575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TMZ1T_RS14580	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TMZ1T_RS14600	COG1794	racemase activity, acting on amino acids and derivatives
TMZ1T_RS14605	COG4636	protein conserved in cyanobacteria
TMZ1T_RS14630	COG0285	dihydrofolate synthase activity
TMZ1T_RS14635	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TMZ1T_RS14640	COG0159	tryptophan synthase activity
TMZ1T_RS14645	COG0133	tryptophan synthase activity
TMZ1T_RS14650	COG0135	phosphoribosylanthranilate isomerase activity
TMZ1T_RS14655	COG0101	tRNA pseudouridine synthase activity
TMZ1T_RS14675	COG0473	3-isopropylmalate dehydrogenase activity
TMZ1T_RS14680	COG0066	3-isopropylmalate dehydratase activity
TMZ1T_RS14690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TMZ1T_RS14695	COG0501	Belongs to the peptidase M48B family
TMZ1T_RS14700	COG2814	Major facilitator Superfamily
TMZ1T_RS14705	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TMZ1T_RS14710	COG0440	acetolactate synthase activity
TMZ1T_RS14715	COG0028	Belongs to the TPP enzyme family
TMZ1T_RS14720	COG0318	PFAM AMP-dependent synthetase and ligase
TMZ1T_RS14740	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TMZ1T_RS14745	COG1250	3-hydroxyacyl-CoA dehydrogenase
TMZ1T_RS14750	COG1802	Transcriptional regulator
TMZ1T_RS14860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMZ1T_RS14865	COG4569	acetaldehyde dehydrogenase (acetylating) activity
TMZ1T_RS14875	COG1802	Transcriptional regulator
TMZ1T_RS14955	COG0277	FAD linked oxidase domain protein
TMZ1T_RS14960	COG1752	Esterase of the alpha-beta hydrolase superfamily
TMZ1T_RS14965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMZ1T_RS14970	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
TMZ1T_RS14980	COG1028	Short-chain dehydrogenase reductase Sdr
TMZ1T_RS14985	COG3243	poly(R)-hydroxyalkanoic acid synthase
TMZ1T_RS15000	COG0564	pseudouridine synthase activity
TMZ1T_RS15010	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TMZ1T_RS15025	COG0411	ABC transporter
TMZ1T_RS15030	COG4214	carbohydrate transport
TMZ1T_RS15035	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMZ1T_RS15050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TMZ1T_RS15065	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
TMZ1T_RS15095	COG0668	transmembrane transport
TMZ1T_RS15115	COG4628	conserved protein (DUF2132)
TMZ1T_RS15120	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TMZ1T_RS15125	COG5433	transposase activity
TMZ1T_RS15145	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TMZ1T_RS15150	COG0210	DNA helicase
TMZ1T_RS15165	COG4584	PFAM Integrase catalytic
TMZ1T_RS15205	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TMZ1T_RS15215	COG2801	Transposase and inactivated derivatives
TMZ1T_RS15230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TMZ1T_RS15310	COG0009	L-threonylcarbamoyladenylate synthase
TMZ1T_RS15315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TMZ1T_RS15320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TMZ1T_RS15325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TMZ1T_RS15335	COG4566	intracellular signal transduction
TMZ1T_RS15350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TMZ1T_RS15355	COG0508	dehydrogenase complex catalyzes the overall conversion of
TMZ1T_RS15360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TMZ1T_RS15390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TMZ1T_RS15390	COG0047	phosphoribosylformylglycinamidine synthase activity
TMZ1T_RS15425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TMZ1T_RS15430	COG0509	glycine decarboxylation via glycine cleavage system
TMZ1T_RS15435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TMZ1T_RS15435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TMZ1T_RS15445	COG1215	transferase activity, transferring glycosyl groups
TMZ1T_RS15450	COG0471	metal ion transport
TMZ1T_RS15460	COG0563	adenylate kinase activity
TMZ1T_RS15465	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TMZ1T_RS15470	COG2835	tetraacyldisaccharide 4'-kinase activity
TMZ1T_RS15475	COG1663	tetraacyldisaccharide 4'-kinase activity
TMZ1T_RS15480	COG0848	biopolymer transport protein
TMZ1T_RS15485	COG0811	peptide transport
TMZ1T_RS15490	COG1570	exodeoxyribonuclease VII activity
TMZ1T_RS15495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TMZ1T_RS15500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TMZ1T_RS15505	COG0784	Response regulator, receiver
TMZ1T_RS15505	COG2198	Histidine kinase
TMZ1T_RS15505	COG0643	Histidine kinase
TMZ1T_RS15510	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
TMZ1T_RS15515	COG0745	RESPONSE REGULATOR receiver
TMZ1T_RS15520	COG0784	Response regulator, receiver
TMZ1T_RS15520	COG0835	chemotaxis
TMZ1T_RS15525	COG0835	chemotaxis
TMZ1T_RS15525	COG0784	Response regulator, receiver
TMZ1T_RS15530	COG1360	Flagellar Motor Protein
TMZ1T_RS15535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TMZ1T_RS15560	COG4657	Part of a membrane complex involved in electron transport
TMZ1T_RS15565	COG2878	Part of a membrane complex involved in electron transport
TMZ1T_RS15575	COG4658	electron transport chain
TMZ1T_RS15580	COG4659	FMN binding
TMZ1T_RS15590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TMZ1T_RS15605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TMZ1T_RS15630	COG3754	Rhamnan synthesis protein F
TMZ1T_RS15635	COG0367	asparagine synthase
TMZ1T_RS15640	COG1215	transferase activity, transferring glycosyl groups
TMZ1T_RS15650	COG1215	transferase activity, transferring glycosyl groups
TMZ1T_RS15660	COG1216	Glycosyl transferase, family 2
TMZ1T_RS15665	COG3119	arylsulfatase activity
TMZ1T_RS15680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TMZ1T_RS15710	COG1696	Membrane protein involved in D-alanine export
TMZ1T_RS15715	COG0297	glycogen (starch) synthase activity
TMZ1T_RS15745	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TMZ1T_RS15755	COG0438	transferase activity, transferring glycosyl groups
TMZ1T_RS15760	COG0438	transferase activity, transferring glycosyl groups
TMZ1T_RS15765	COG0367	asparagine synthase
TMZ1T_RS15770	COG0438	transferase activity, transferring glycosyl groups
TMZ1T_RS15775	COG0438	transferase activity, transferring glycosyl groups
TMZ1T_RS15795	COG3409	Peptidoglycan-binding domain 1 protein
TMZ1T_RS15795	COG3267	Type II secretory pathway component ExeA
TMZ1T_RS15805	COG0489	protein tyrosine kinase activity
TMZ1T_RS15830	COG1136	(ABC) transporter
TMZ1T_RS15830	COG0577	efflux transmembrane transporter activity
TMZ1T_RS15840	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TMZ1T_RS15860	COG0436	Aminotransferase
TMZ1T_RS15865	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TMZ1T_RS15870	COG0235	Class ii aldolase
TMZ1T_RS15875	COG2084	Dehydrogenase
TMZ1T_RS15880	COG2084	Dehydrogenase
TMZ1T_RS15885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TMZ1T_RS15895	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TMZ1T_RS15900	COG0583	DNA-binding transcription factor activity
TMZ1T_RS15905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TMZ1T_RS15920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMZ1T_RS15930	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TMZ1T_RS15945	COG2814	Major facilitator Superfamily
TMZ1T_RS15955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TMZ1T_RS15960	COG0203	ribosomal protein L17
TMZ1T_RS15965	COG0202	RNA polymerase activity
TMZ1T_RS15970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TMZ1T_RS15975	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TMZ1T_RS15980	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TMZ1T_RS15985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TMZ1T_RS15990	COG0201	protein transport
TMZ1T_RS15995	COG0200	Binds to the 23S rRNA
TMZ1T_RS16000	COG1841	ribosomal large subunit assembly
TMZ1T_RS16005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TMZ1T_RS16010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TMZ1T_RS16015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TMZ1T_RS16020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TMZ1T_RS16025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TMZ1T_RS16030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TMZ1T_RS16035	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TMZ1T_RS16040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TMZ1T_RS16045	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TMZ1T_RS16050	COG0255	Belongs to the universal ribosomal protein uL29 family
TMZ1T_RS16055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TMZ1T_RS16060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TMZ1T_RS16065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TMZ1T_RS16070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TMZ1T_RS16075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TMZ1T_RS16080	COG0089	rRNA binding
TMZ1T_RS16085	COG0088	Forms part of the polypeptide exit tunnel
TMZ1T_RS16090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TMZ1T_RS16095	COG0051	transcription antitermination factor activity, RNA binding
TMZ1T_RS16100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TMZ1T_RS16105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TMZ1T_RS16110	COG0049	tRNA binding
TMZ1T_RS16115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TMZ1T_RS16120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TMZ1T_RS16125	COG0085	RNA polymerase activity
TMZ1T_RS16130	COG0222	ribosome binding
TMZ1T_RS16135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TMZ1T_RS16140	COG0081	regulation of translation
TMZ1T_RS16145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TMZ1T_RS16155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TMZ1T_RS16165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TMZ1T_RS16200	COG4999	Histidine kinase
TMZ1T_RS16200	COG3850	Histidine kinase
TMZ1T_RS16200	COG2205	protein histidine kinase activity
TMZ1T_RS16200	COG3437	response regulator, receiver
TMZ1T_RS16210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TMZ1T_RS16215	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TMZ1T_RS16245	COG1022	Amp-dependent synthetase and ligase
TMZ1T_RS16275	COG1703	isobutyryl-CoA mutase activity
TMZ1T_RS16275	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TMZ1T_RS16275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TMZ1T_RS16305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TMZ1T_RS16310	COG0557	exoribonuclease II activity
TMZ1T_RS16325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TMZ1T_RS16330	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TMZ1T_RS16340	COG0330	HflC and HflK could
TMZ1T_RS16345	COG0330	HflC and HflK could
TMZ1T_RS16350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TMZ1T_RS16355	COG1923	regulation of RNA biosynthetic process
TMZ1T_RS16360	COG1160	GTP binding
TMZ1T_RS16365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TMZ1T_RS16375	COG0124	histidyl-tRNA synthetase
TMZ1T_RS16380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TMZ1T_RS16385	COG1426	Protein conserved in bacteria
TMZ1T_RS16395	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TMZ1T_RS16400	COG0105	UTP biosynthetic process
TMZ1T_RS16405	COG0586	Pfam SNARE associated Golgi protein
TMZ1T_RS16435	COG0037	tRNA processing
TMZ1T_RS16440	COG0825	malonyl-CoA metabolic process
TMZ1T_RS16455	COG0583	DNA-binding transcription factor activity
TMZ1T_RS16465	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TMZ1T_RS16470	COG0343	queuine tRNA-ribosyltransferase activity
TMZ1T_RS16475	COG1862	Preprotein translocase
TMZ1T_RS16480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TMZ1T_RS16485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TMZ1T_RS16500	COG2967	ApaG domain
TMZ1T_RS16505	COG3447	MASE1 domain protein
TMZ1T_RS16505	COG5001	Diguanylate cyclase
TMZ1T_RS16505	COG5002	protein histidine kinase activity
TMZ1T_RS16520	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TMZ1T_RS16525	COG0653	protein targeting
TMZ1T_RS16540	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TMZ1T_RS16555	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TMZ1T_RS16560	COG1181	Belongs to the D-alanine--D-alanine ligase family
TMZ1T_RS16565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TMZ1T_RS16570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TMZ1T_RS16575	COG0772	Belongs to the SEDS family
TMZ1T_RS16580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TMZ1T_RS16585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TMZ1T_RS16590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TMZ1T_RS16595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TMZ1T_RS16605	COG3116	cell division
TMZ1T_RS16610	COG0275	rRNA processing
TMZ1T_RS16615	COG2001	Belongs to the MraZ family
TMZ1T_RS16625	COG0418	dihydroorotase activity
TMZ1T_RS16635	COG0792	nuclease activity
TMZ1T_RS16640	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TMZ1T_RS16650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TMZ1T_RS16660	COG0511	ligase activity, forming carbon-carbon bonds
TMZ1T_RS16665	COG0439	Biotin carboxylase
TMZ1T_RS16670	COG2264	protein methyltransferase activity
TMZ1T_RS16685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TMZ1T_RS16690	COG0537	adenosine 5'-monophosphoramidase activity
TMZ1T_RS16705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TMZ1T_RS16725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TMZ1T_RS16730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TMZ1T_RS16735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TMZ1T_RS16750	COG0351	phosphomethylpyrimidine kinase
TMZ1T_RS16755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TMZ1T_RS16760	COG1063	alcohol dehydrogenase
TMZ1T_RS16770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TMZ1T_RS16775	COG4647	ligase activity
TMZ1T_RS16780	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
TMZ1T_RS16785	COG0145	ligase activity
TMZ1T_RS16790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TMZ1T_RS16795	COG2885	chlorophyll binding
TMZ1T_RS16800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TMZ1T_RS16805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TMZ1T_RS16810	COG1566	PFAM secretion protein HlyD family protein
TMZ1T_RS16815	COG1136	(ABC) transporter
TMZ1T_RS16815	COG0577	efflux transmembrane transporter activity
TMZ1T_RS16820	COG0577	efflux transmembrane transporter activity
TMZ1T_RS16820	COG1136	(ABC) transporter
TMZ1T_RS16825	COG1136	(ABC) transporter
TMZ1T_RS16825	COG0577	efflux transmembrane transporter activity
TMZ1T_RS16830	COG1509	lysine 2,3-aminomutase activity
TMZ1T_RS16840	COG2321	neutral zinc metallopeptidase
TMZ1T_RS16845	COG4770	biotin carboxylase activity
TMZ1T_RS16850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TMZ1T_RS16855	COG1703	isobutyryl-CoA mutase activity
TMZ1T_RS16860	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TMZ1T_RS16860	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TMZ1T_RS16865	COG1802	Transcriptional regulator
TMZ1T_RS16870	COG1253	flavin adenine dinucleotide binding
TMZ1T_RS16875	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TMZ1T_RS16880	COG3162	membrane
TMZ1T_RS16885	COG1024	Enoyl-CoA hydratase
TMZ1T_RS16900	COG1136	(ABC) transporter
TMZ1T_RS16910	COG0735	belongs to the Fur family
TMZ1T_RS16915	COG1121	(ABC) transporter
TMZ1T_RS16920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TMZ1T_RS16925	COG0803	Belongs to the bacterial solute-binding protein 9 family
TMZ1T_RS16930	COG1280	lysine exporter protein (LysE YggA)
TMZ1T_RS16940	COG2205	protein histidine kinase activity
TMZ1T_RS16945	COG0745	RESPONSE REGULATOR receiver
TMZ1T_RS16950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TMZ1T_RS16955	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TMZ1T_RS16965	COG0129	dihydroxy-acid dehydratase activity
TMZ1T_RS16970	COG3132	Protein of unknown function, DUF480
TMZ1T_RS16975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TMZ1T_RS16985	COG5001	Diguanylate cyclase
TMZ1T_RS16985	COG3300	MHYT domain
TMZ1T_RS17025	COG0735	belongs to the Fur family
TMZ1T_RS17030	COG1858	cytochrome C peroxidase
TMZ1T_RS17035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMZ1T_RS17040	COG0577	efflux transmembrane transporter activity
TMZ1T_RS17040	COG1136	(ABC) transporter
TMZ1T_RS17050	COG4774	siderophore transport
TMZ1T_RS17070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TMZ1T_RS17085	COG0318	PFAM AMP-dependent synthetase and ligase
TMZ1T_RS17100	COG2119	membrane
TMZ1T_RS17125	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TMZ1T_RS17155	COG4608	Belongs to the ABC transporter superfamily
TMZ1T_RS17160	COG0444	Belongs to the ABC transporter superfamily
TMZ1T_RS17165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMZ1T_RS17170	COG0601	transmembrane transport
TMZ1T_RS17205	COG2226	methyltransferase
TMZ1T_RS17230	COG2814	Major facilitator Superfamily
TMZ1T_RS17245	COG1115	amino acid carrier protein
TMZ1T_RS17305	COG0477	Major facilitator Superfamily
TMZ1T_RS17325	COG1280	lysine exporter protein (LysE YggA)
TMZ1T_RS17340	COG0534	Mate efflux family protein
TMZ1T_RS17345	COG0259	pyridoxamine-phosphate oxidase activity
TMZ1T_RS17355	COG1139	Iron-sulfur cluster binding protein
TMZ1T_RS17360	COG0247	lactate metabolic process
TMZ1T_RS17370	COG1024	Enoyl-CoA hydratase
TMZ1T_RS17375	COG1944	ATP diphosphatase activity
TMZ1T_RS17395	COG3586	endonuclease activity
TMZ1T_RS17405	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TMZ1T_RS17415	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TMZ1T_RS17420	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
TMZ1T_RS17445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TMZ1T_RS17455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TMZ1T_RS17460	COG0405	Gamma-glutamyltransferase
TMZ1T_RS17465	COG3300	MHYT domain
TMZ1T_RS17465	COG5001	Diguanylate cyclase
TMZ1T_RS17470	COG1132	(ABC) transporter
TMZ1T_RS17475	COG3634	alkyl hydroperoxide reductase activity
TMZ1T_RS17490	COG2884	Cell division ATP-binding protein ftsE
TMZ1T_RS17500	COG0612	Peptidase, M16
TMZ1T_RS17505	COG0612	Peptidase, M16
TMZ1T_RS17510	COG0742	ribosomal rna small subunit methyltransferase
TMZ1T_RS17515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TMZ1T_RS17520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TMZ1T_RS17525	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TMZ1T_RS17530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TMZ1T_RS17540	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
TMZ1T_RS17545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TMZ1T_RS17555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TMZ1T_RS17560	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TMZ1T_RS17565	COG0193	aminoacyl-tRNA hydrolase activity
TMZ1T_RS17575	COG0012	GTP binding
TMZ1T_RS17585	COG0242	peptide deformylase activity
TMZ1T_RS17605	COG0463	Glycosyl transferase, family 2
TMZ1T_RS17615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TMZ1T_RS17620	COG1832	CoA-binding protein
TMZ1T_RS17625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TMZ1T_RS17630	COG3568	Endonuclease Exonuclease Phosphatase
TMZ1T_RS17635	COG0583	DNA-binding transcription factor activity
TMZ1T_RS17645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TMZ1T_RS17655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TMZ1T_RS17660	COG0174	glutamine synthetase
TMZ1T_RS17670	COG3852	Histidine kinase
TMZ1T_RS17685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TMZ1T_RS17690	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TMZ1T_RS17700	COG0237	dephospho-CoA kinase activity
TMZ1T_RS17705	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
TMZ1T_RS17710	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TMZ1T_RS17715	COG0352	thiamine-phosphate diphosphorylase activity
TMZ1T_RS17725	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
TMZ1T_RS17730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TMZ1T_RS17735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TMZ1T_RS17765	COG0305	Participates in initiation and elongation during chromosome replication
TMZ1T_RS17770	COG0359	binds to the 23S rRNA
TMZ1T_RS17775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TMZ1T_RS17780	COG2965	DNA replication, synthesis of RNA primer
TMZ1T_RS17785	COG0360	Binds together with S18 to 16S ribosomal RNA
TMZ1T_RS17800	COG1618	nucleotide phosphatase activity, acting on free nucleotides
TMZ1T_RS17800	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TMZ1T_RS17810	COG1968	undecaprenyl-diphosphatase activity
TMZ1T_RS17815	COG3150	esterase
TMZ1T_RS17820	COG2226	methyltransferase
TMZ1T_RS17830	COG0557	exoribonuclease II activity
TMZ1T_RS17840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TMZ1T_RS17845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TMZ1T_RS17850	COG2239	Acts as a magnesium transporter
TMZ1T_RS17855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TMZ1T_RS17865	COG0352	thiamine-phosphate diphosphorylase activity
TMZ1T_RS17870	COG0351	phosphomethylpyrimidine kinase
TMZ1T_RS17875	COG1773	rubredoxin
TMZ1T_RS17890	COG0835	chemotaxis
TMZ1T_RS17895	COG0840	transmembrane signaling receptor activity
TMZ1T_RS17905	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TMZ1T_RS17910	COG0415	Belongs to the DNA photolyase family
TMZ1T_RS17915	COG1678	Uncharacterized ACR, COG1678
TMZ1T_RS17920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TMZ1T_RS17925	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TMZ1T_RS17930	COG0540	Belongs to the ATCase OTCase family
TMZ1T_RS17980	COG0437	4 iron, 4 sulfur cluster binding
TMZ1T_RS17985	COG3383	formate dehydrogenase (NAD+) activity
TMZ1T_RS17985	COG0243	molybdopterin cofactor binding
TMZ1T_RS18020	COG0746	molybdenum cofactor guanylyltransferase activity
TMZ1T_RS18030	COG1252	NADH dehydrogenase
TMZ1T_RS18035	COG1763	Mo-molybdopterin cofactor biosynthetic process
TMZ1T_RS18040	COG3852	Histidine kinase
TMZ1T_RS18045	COG2204	response regulator
TMZ1T_RS18050	COG1981	membrane
TMZ1T_RS18065	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TMZ1T_RS18070	COG5002	protein histidine kinase activity
TMZ1T_RS18080	COG4654	Cytochrome c, class I
TMZ1T_RS18085	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TMZ1T_RS18085	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TMZ1T_RS18090	COG1492	cobalamin metabolic process
TMZ1T_RS18105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TMZ1T_RS18140	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TMZ1T_RS18165	COG0427	acetyl-CoA hydrolase
TMZ1T_RS18170	COG0517	IMP dehydrogenase activity
TMZ1T_RS18170	COG0516	GMP reductase activity
TMZ1T_RS18175	COG0688	phosphatidylethanolamine metabolic process
TMZ1T_RS18195	COG1648	precorrin-2 dehydrogenase activity
TMZ1T_RS18195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TMZ1T_RS18215	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TMZ1T_RS18220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TMZ1T_RS18225	COG4206	TonB-dependent receptor
TMZ1T_RS18235	COG4636	protein conserved in cyanobacteria
TMZ1T_RS18240	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TMZ1T_RS18245	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TMZ1T_RS18255	COG2831	hemolysin activation secretion protein
TMZ1T_RS18260	COG0406	alpha-ribazole phosphatase activity
TMZ1T_RS18305	COG1215	transferase activity, transferring glycosyl groups
TMZ1T_RS18320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TMZ1T_RS18330	COG5433	transposase activity
TMZ1T_RS18350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TMZ1T_RS18380	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TMZ1T_RS18385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TMZ1T_RS18390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TMZ1T_RS18430	COG0438	transferase activity, transferring glycosyl groups
TMZ1T_RS18435	COG5433	transposase activity
TMZ1T_RS18445	COG4636	protein conserved in cyanobacteria
TMZ1T_RS18450	COG4636	protein conserved in cyanobacteria
TMZ1T_RS18460	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TMZ1T_RS18470	COG1132	(ABC) transporter
TMZ1T_RS18475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TMZ1T_RS18475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TMZ1T_RS18495	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TMZ1T_RS18510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TMZ1T_RS18515	COG0799	negative regulation of ribosome biogenesis
TMZ1T_RS18520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TMZ1T_RS18525	COG0424	maF-like protein
TMZ1T_RS18530	COG1530	ribonuclease E activity
TMZ1T_RS18535	COG4636	protein conserved in cyanobacteria
TMZ1T_RS18555	COG0559	Belongs to the binding-protein-dependent transport system permease family
TMZ1T_RS18565	COG0632	four-way junction helicase activity
TMZ1T_RS18570	COG2255	four-way junction helicase activity
TMZ1T_RS18585	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TMZ1T_RS18595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TMZ1T_RS18600	COG1560	Kdo2-lipid A biosynthetic process
TMZ1T_RS18610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TMZ1T_RS18620	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TMZ1T_RS18625	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TMZ1T_RS18635	COG4206	TonB-dependent receptor
TMZ1T_RS18645	COG5002	protein histidine kinase activity
TMZ1T_RS18645	COG2205	protein histidine kinase activity
TMZ1T_RS18645	COG0784	Response regulator, receiver
TMZ1T_RS18660	COG4206	TonB-dependent receptor
TMZ1T_RS18670	COG0433	COG0433 Predicted ATPase
TMZ1T_RS18675	COG0217	transcriptional regulatory protein
TMZ1T_RS18685	COG0393	Putative heavy-metal-binding
TMZ1T_RS18690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TMZ1T_RS18710	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
TMZ1T_RS18735	COG4566	intracellular signal transduction
TMZ1T_RS18745	COG0745	RESPONSE REGULATOR receiver
TMZ1T_RS18750	COG4191	Histidine kinase
TMZ1T_RS18785	COG2308	Evidence 4 Homologs of previously reported genes of
TMZ1T_RS18820	COG0625	glutathione transferase activity
TMZ1T_RS18830	COG2161	toxin-antitoxin pair type II binding
TMZ1T_RS18875	COG4115	mRNA cleavage
TMZ1T_RS18880	COG2161	toxin-antitoxin pair type II binding
TMZ1T_RS18910	COG1132	(ABC) transporter
TMZ1T_RS18920	COG0438	transferase activity, transferring glycosyl groups
TMZ1T_RS18955	COG4636	protein conserved in cyanobacteria
TMZ1T_RS18970	COG4232	protein-disulfide reductase activity
TMZ1T_RS18985	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TMZ1T_RS18990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TMZ1T_RS19000	COG0375	protein maturation
TMZ1T_RS19010	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TMZ1T_RS19015	COG0298	carbon dioxide binding
TMZ1T_RS19020	COG0409	Hydrogenase expression formation protein
TMZ1T_RS19025	COG0309	Hydrogenase expression formation protein (HypE)
TMZ1T_RS19040	COG0765	amino acid transport
TMZ1T_RS19045	COG1126	abc transporter atp-binding protein
TMZ1T_RS19075	COG0829	nickel cation binding
TMZ1T_RS19080	COG0831	urea catabolic process
TMZ1T_RS19085	COG0832	Belongs to the urease beta subunit family
TMZ1T_RS19090	COG0804	urea catabolic process
TMZ1T_RS19095	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TMZ1T_RS19100	COG0830	nickel cation binding
TMZ1T_RS19105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TMZ1T_RS19120	COG1335	isochorismatase
TMZ1T_RS19125	COG1012	belongs to the aldehyde dehydrogenase family
TMZ1T_RS19135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TMZ1T_RS19145	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
TMZ1T_RS19150	COG0415	Belongs to the DNA photolyase family
TMZ1T_RS19155	COG0415	Belongs to the DNA photolyase family
TMZ1T_RS19170	COG0322	excinuclease ABC activity
TMZ1T_RS19180	COG0438	transferase activity, transferring glycosyl groups
TMZ1T_RS19200	COG0826	peptidase U32
TMZ1T_RS19260	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TMZ1T_RS19265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMZ1T_RS19285	COG2132	Multicopper oxidase
TMZ1T_RS19305	COG5002	protein histidine kinase activity
TMZ1T_RS19345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMZ1T_RS19350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TMZ1T_RS19365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TMZ1T_RS19375	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TMZ1T_RS19390	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TMZ1T_RS19395	COG4133	protoheme IX ABC transporter activity
TMZ1T_RS19400	COG3005	denitrification pathway
TMZ1T_RS19405	COG3043	anaerobic respiration
TMZ1T_RS19410	COG0348	domain, Protein
TMZ1T_RS19415	COG0437	4 iron, 4 sulfur cluster binding
TMZ1T_RS19420	COG0243	molybdopterin cofactor binding
TMZ1T_RS19435	COG2197	response regulator
TMZ1T_RS19440	COG3850	Histidine kinase
TMZ1T_RS19460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TMZ1T_RS19465	COG1758	RNA polymerase activity
TMZ1T_RS19470	COG0194	GDP metabolic process
TMZ1T_RS19480	COG1561	YicC-like family, N-terminal region
TMZ1T_RS19485	COG0515	serine threonine protein kinase
TMZ1T_RS19490	COG0631	protein serine/threonine phosphatase activity
TMZ1T_RS19495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TMZ1T_RS19500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TMZ1T_RS19505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TMZ1T_RS19525	COG2814	Major facilitator Superfamily
TMZ1T_RS19530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TMZ1T_RS19535	COG1021	2,3-dihydroxybenzoate-AMP ligase
TMZ1T_RS19555	COG4584	PFAM Integrase catalytic
TMZ1T_RS19570	COG1902	pentaerythritol trinitrate reductase activity
TMZ1T_RS19570	COG0446	pyridine nucleotide-disulphide oxidoreductase
TMZ1T_RS19580	COG1012	belongs to the aldehyde dehydrogenase family
TMZ1T_RS19595	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TMZ1T_RS19600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMZ1T_RS19615	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
TMZ1T_RS19630	COG2205	protein histidine kinase activity
TMZ1T_RS19655	COG1881	PFAM PEBP family protein
TMZ1T_RS19660	COG0616	signal peptide processing
TMZ1T_RS19665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TMZ1T_RS19670	COG2022	thiamine diphosphate biosynthetic process
TMZ1T_RS19680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TMZ1T_RS19685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TMZ1T_RS19685	COG2813	Specifically methylates the guanine in position
TMZ1T_RS19700	COG2223	nitrite transmembrane transporter activity
TMZ1T_RS19725	COG0656	L-ascorbic acid biosynthetic process
TMZ1T_RS19735	COG0288	reversible hydration of carbon dioxide
TMZ1T_RS19740	COG1940	carbohydrate kinase activity
TMZ1T_RS19745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TMZ1T_RS19750	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TMZ1T_RS19760	COG0569	domain protein
TMZ1T_RS19765	COG2204	response regulator
TMZ1T_RS19770	COG5000	phosphorelay sensor kinase activity
TMZ1T_RS19785	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TMZ1T_RS19795	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TMZ1T_RS19800	COG0706	membrane insertase activity
TMZ1T_RS19805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TMZ1T_RS19810	COG0594	ribonuclease P activity
TMZ1T_RS19835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TMZ1T_RS20205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TMZ1T_RS20300	COG0463	Glycosyl transferase, family 2