locus-tag	class	description
TOT_010000004	COG2274	protein secretion by the type I secretion system
TOT_010000006	COG1132	(ABC) transporter
TOT_010000008	COG1132	(ABC) transporter
TOT_010000093	COG3588	fructose-bisphosphate aldolase
TOT_010000104	COG2274	protein secretion by the type I secretion system
TOT_010000107	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOT_010000164	COG0450	alkyl hydroperoxide reductase
TOT_010000188	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TOT_010000326	COG2815	serine threonine protein kinase
TOT_010000326	COG0515	serine threonine protein kinase
TOT_010000355	COG0557	exoribonuclease II activity
TOT_010000355	COG0557	exoribonuclease II activity
TOT_010000356	COG0308	aminopeptidase N
TOT_010000404	COG0423	glycine-tRNA ligase activity
TOT_010000450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TOT_010000551	COG2815	serine threonine protein kinase
TOT_010000551	COG0515	serine threonine protein kinase
TOT_010000551	COG2815	serine threonine protein kinase
TOT_010000551	COG0515	serine threonine protein kinase
TOT_010000602	COG0081	regulation of translation
TOT_010000614	COG0584	glycerophosphoryl diester phosphodiesterase
TOT_010000664	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TOT_010000670	COG0045	succinate-CoA ligase (ADP-forming) activity
TOT_010000685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TOT_010000783	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TOT_010000815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOT_010001014	COG2814	Major facilitator Superfamily
TOT_010001085	COG1254	Belongs to the acylphosphatase family
TOT_010001152	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOT_010001241	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TOT_010001248	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TOT_010001279	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TOT_010001314	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TOT_010001316	COG0326	Molecular chaperone. Has ATPase activity
TOT_010001371	COG0688	phosphatidylethanolamine metabolic process
TOT_020000006	COG1132	(ABC) transporter
TOT_020000025	COG0123	including yeast histone deacetylase and acetoin utilization protein
TOT_020000038	COG1899	peptidyl-lysine modification to peptidyl-hypusine
TOT_020000137	COG0443	Heat shock 70 kDa protein
TOT_020000204	COG0484	heat shock protein binding
TOT_020000328	COG1132	(ABC) transporter
TOT_020000382	COG2274	protein secretion by the type I secretion system
TOT_020000384	COG2274	protein secretion by the type I secretion system
TOT_020000385	COG1132	(ABC) transporter
TOT_020000413	COG0105	UTP biosynthetic process
TOT_020000426	COG0813	purine-nucleoside phosphorylase activity
TOT_020000487	COG0306	phosphate transporter
TOT_020000496	COG0514	ATP-dependent DNA helicase (RecQ)
TOT_020000552	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TOT_020000557	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TOT_020000566	COG0194	GDP metabolic process
TOT_020000630	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TOT_020000655	COG1132	(ABC) transporter
TOT_020000656	COG1132	(ABC) transporter
TOT_020000720	COG1132	(ABC) transporter
TOT_020000721	COG1132	(ABC) transporter
TOT_020000722	COG1132	(ABC) transporter
TOT_020000759	COG0037	tRNA processing
TOT_020000951	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TOT_020000970	COG2274	protein secretion by the type I secretion system
TOT_020000985	COG1132	(ABC) transporter
TOT_020001032	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TOT_020001102	COG5277	cytoskeleton organization
TOT_030000147	COG0459	protein refolding
TOT_030000324	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TOT_030000324	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TOT_030000436	COG0495	leucyl-tRNA aminoacylation
TOT_030000487	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TOT_030000558	COG1160	GTP binding
TOT_030000644	COG1132	(ABC) transporter
TOT_030000660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TOT_030000665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TOT_030000808	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TOT_030000867	COG0203	ribosomal protein L17
TOT_030000927	COG0222	ribosome binding
TOT_030000928	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TOT_040000006	COG1132	(ABC) transporter
TOT_040000017	COG1132	(ABC) transporter
TOT_040000022	COG1132	(ABC) transporter
TOT_040000054	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOT_040000255	COG2815	serine threonine protein kinase
TOT_040000255	COG0515	serine threonine protein kinase
TOT_040000275	COG1132	(ABC) transporter
TOT_040000334	COG0316	Belongs to the HesB IscA family
TOT_040000416	COG0514	ATP-dependent DNA helicase (RecQ)
TOT_040000473	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TOT_040000500	COG1196	nuclear chromosome segregation
TOT_040000500	COG1196	nuclear chromosome segregation
TOT_040000579	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TOT_040000616	COG1132	(ABC) transporter
TOT_040000617	COG1132	(ABC) transporter
TOT_040000740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TOT_040000880	COG4589	Belongs to the CDS family
TOT_040000929	COG2815	serine threonine protein kinase
TOT_040000929	COG0515	serine threonine protein kinase
TOT_040000976	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TOT_050000010	COG0542	response to heat
TOT_050000011	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit