locus-tag	class	description
TPH_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TPH_RS00010	COG0592	DNA-directed DNA polymerase activity
TPH_RS00025	COG0187	DNA topoisomerase II activity
TPH_RS00030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TPH_RS00050	COG0583	DNA-binding transcription factor activity
TPH_RS00055	COG0583	DNA-binding transcription factor activity
TPH_RS00065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TPH_RS00070	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TPH_RS00075	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TPH_RS00085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TPH_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TPH_RS00125	COG0594	ribonuclease P activity
TPH_RS00130	COG0706	membrane insertase activity
TPH_RS00135	COG1847	R3H domain protein
TPH_RS00140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TPH_RS00145	COG0357	Ribosomal RNA small subunit methyltransferase G
TPH_RS00150	COG1475	DNA binding
TPH_RS00160	COG1192	Involved in chromosome partitioning
TPH_RS00165	COG1475	DNA binding
TPH_RS00175	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TPH_RS00180	COG1691	(AIR) carboxylase
TPH_RS00190	COG0739	heme binding
TPH_RS00245	COG0517	IMP dehydrogenase activity
TPH_RS00255	COG1053	succinate dehydrogenase
TPH_RS00270	COG2508	Transcriptional regulator
TPH_RS00295	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
TPH_RS00300	COG1615	UPF0182 protein
TPH_RS00345	COG0709	Synthesizes selenophosphate from selenide and ATP
TPH_RS00350	COG0425	Belongs to the sulfur carrier protein TusA family
TPH_RS00360	COG0360	Binds together with S18 to 16S ribosomal RNA
TPH_RS00365	COG0629	single-stranded DNA binding
TPH_RS00370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TPH_RS00385	COG1598	PFAM Uncharacterised protein family UPF0150
TPH_RS00395	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TPH_RS00400	COG0359	binds to the 23S rRNA
TPH_RS00405	COG0470	DNA polymerase III
TPH_RS00405	COG1067	ATP-dependent peptidase activity
TPH_RS00410	COG0305	Participates in initiation and elongation during chromosome replication
TPH_RS00455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TPH_RS00515	COG1598	PFAM Uncharacterised protein family UPF0150
TPH_RS00555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPH_RS00575	COG3835	regulator
TPH_RS00580	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TPH_RS00585	COG1333	cytochrome c biogenesis protein
TPH_RS00590	COG2508	Transcriptional regulator
TPH_RS00600	COG1053	succinate dehydrogenase
TPH_RS00605	COG1053	succinate dehydrogenase
TPH_RS00610	COG1053	succinate dehydrogenase
TPH_RS00615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPH_RS00620	COG1120	ATPase activity
TPH_RS00625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPH_RS00635	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TPH_RS00665	COG0437	4 iron, 4 sulfur cluster binding
TPH_RS00680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TPH_RS00750	COG0477	Major facilitator Superfamily
TPH_RS00770	COG0746	molybdenum cofactor guanylyltransferase activity
TPH_RS00775	COG1763	Mo-molybdopterin cofactor biosynthetic process
TPH_RS00780	COG0303	'Molybdopterin
TPH_RS00785	COG0303	'Molybdopterin
TPH_RS00805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPH_RS00810	COG1120	ATPase activity
TPH_RS00815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPH_RS00820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TPH_RS00830	COG0725	ABC transporter, periplasmic molybdate-binding protein
TPH_RS00840	COG3842	ATPase activity
TPH_RS00850	COG0315	cyclic pyranopterin monophosphate synthase activity
TPH_RS00860	COG0521	Mo-molybdopterin cofactor biosynthetic process
TPH_RS00870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TPH_RS00895	COG0437	4 iron, 4 sulfur cluster binding
TPH_RS00905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TPH_RS00910	COG0746	molybdenum cofactor guanylyltransferase activity
TPH_RS00915	COG1763	Mo-molybdopterin cofactor biosynthetic process
TPH_RS00920	COG0303	'Molybdopterin
TPH_RS00930	COG2188	Transcriptional regulator
TPH_RS00935	COG5012	cobalamin binding
TPH_RS00970	COG0745	RESPONSE REGULATOR receiver
TPH_RS00985	COG3481	metal-dependent phosphohydrolase, HD sub domain
TPH_RS00990	COG2508	Transcriptional regulator
TPH_RS01015	COG1598	PFAM Uncharacterised protein family UPF0150
TPH_RS01020	COG1724	mRNA binding
TPH_RS01090	COG0840	transmembrane signaling receptor activity
TPH_RS01150	COG1363	Peptidase, m42
TPH_RS01155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TPH_RS01165	COG1309	transcriptional regulator
TPH_RS01190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPH_RS01245	COG5002	protein histidine kinase activity
TPH_RS01250	COG0745	RESPONSE REGULATOR receiver
TPH_RS01310	COG0513	Belongs to the DEAD box helicase family
TPH_RS01330	COG4464	protein tyrosine phosphatase activity
TPH_RS01350	COG1361	Conserved repeat domain
TPH_RS01350	COG2911	Protein conserved in bacteria
TPH_RS01350	COG3266	domain, Protein
TPH_RS01365	COG3944	biosynthesis protein
TPH_RS01370	COG0489	protein tyrosine kinase activity
TPH_RS01380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPH_RS01385	COG1086	Polysaccharide biosynthesis protein
TPH_RS01390	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TPH_RS01420	COG0438	transferase activity, transferring glycosyl groups
TPH_RS01430	COG0438	transferase activity, transferring glycosyl groups
TPH_RS01485	COG0840	transmembrane signaling receptor activity
TPH_RS01565	COG2199	diguanylate cyclase activity
TPH_RS01565	COG2203	Gaf domain
TPH_RS01640	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TPH_RS01675	COG0534	Mate efflux family protein
TPH_RS01685	COG1078	dGTPase activity
TPH_RS01700	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TPH_RS01700	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TPH_RS01725	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TPH_RS01740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPH_RS01745	COG1120	ATPase activity
TPH_RS01775	COG1131	(ABC) transporter
TPH_RS01795	COG0747	negative chemotaxis
TPH_RS01800	COG0601	transmembrane transport
TPH_RS01805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPH_RS01815	COG4608	Belongs to the ABC transporter superfamily
TPH_RS01820	COG2226	methyltransferase
TPH_RS01830	COG5012	cobalamin binding
TPH_RS01835	COG0646	methionine synthase
TPH_RS01835	COG1410	methionine synthase
TPH_RS01840	COG5012	cobalamin binding
TPH_RS01850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TPH_RS01885	COG3869	Catalyzes the specific phosphorylation of arginine residues in
TPH_RS01890	COG0542	response to heat
TPH_RS01905	COG0778	Nitroreductase
TPH_RS01930	COG1053	succinate dehydrogenase
TPH_RS01930	COG3976	FMN-binding domain protein
TPH_RS01940	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TPH_RS01945	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TPH_RS01955	COG1329	Transcriptional regulator
TPH_RS01960	COG4956	integral membrane protein (PIN domain superfamily)
TPH_RS01965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TPH_RS01965	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TPH_RS01970	COG3829	transcription factor binding
TPH_RS01970	COG3290	protein histidine kinase activity
TPH_RS01990	COG0501	Belongs to the peptidase M48B family
TPH_RS02000	COG0616	signal peptide processing
TPH_RS02035	COG0459	protein refolding
TPH_RS02040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TPH_RS02065	COG1032	radical SAM domain protein
TPH_RS02095	COG1584	GPR1 FUN34 yaaH family protein
TPH_RS02100	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
TPH_RS02105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TPH_RS02110	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TPH_RS02115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TPH_RS02130	COG2414	aldehyde ferredoxin oxidoreductase
TPH_RS02140	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TPH_RS02220	COG1122	ATPase activity
TPH_RS02255	COG3103	Sh3 type 3 domain protein
TPH_RS02255	COG1388	LysM domain
TPH_RS02255	COG0791	NLP P60 protein
TPH_RS02265	COG2226	methyltransferase
TPH_RS02270	COG1846	Transcriptional regulator
TPH_RS02280	COG5564	TIM-barrel signal transduction protein
TPH_RS02280	COG2204	response regulator
TPH_RS02290	COG2045	Belongs to the ComB family
TPH_RS02295	COG5564	TIM-barrel signal transduction protein
TPH_RS02300	COG1850	ribulose-bisphosphate carboxylase activity
TPH_RS02320	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TPH_RS02345	COG0840	transmembrane signaling receptor activity
TPH_RS02355	COG0544	peptidyl-prolyl cis-trans isomerase activity
TPH_RS02360	COG0740	serine-type endopeptidase activity
TPH_RS02365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TPH_RS02370	COG0470	DNA polymerase III
TPH_RS02370	COG1067	ATP-dependent peptidase activity
TPH_RS02375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TPH_RS02385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TPH_RS02410	COG1414	Transcriptional regulator
TPH_RS02430	COG3426	butyrate kinase activity
TPH_RS02435	COG0280	phosphate acetyltransferase
TPH_RS02455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TPH_RS02460	COG0745	RESPONSE REGULATOR receiver
TPH_RS02465	COG5002	protein histidine kinase activity
TPH_RS02470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TPH_RS02475	COG0704	Plays a role in the regulation of phosphate uptake
TPH_RS02480	COG0573	inorganic phosphate transmembrane transporter activity
TPH_RS02485	COG0581	inorganic phosphate transmembrane transporter activity
TPH_RS02495	COG0525	valine-tRNA ligase activity
TPH_RS02500	COG1045	serine acetyltransferase
TPH_RS02505	COG0215	cysteine-tRNA ligase activity
TPH_RS02515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TPH_RS02520	COG3688	RNA-binding protein containing a PIN domain
TPH_RS02555	COG0835	chemotaxis
TPH_RS02560	COG2201	protein-glutamate methylesterase activity
TPH_RS02570	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TPH_RS02575	COG0745	RESPONSE REGULATOR receiver
TPH_RS02580	COG0643	Histidine kinase
TPH_RS02580	COG2198	Histidine kinase
TPH_RS02595	COG0745	RESPONSE REGULATOR receiver
TPH_RS02600	COG0840	transmembrane signaling receptor activity
TPH_RS02605	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TPH_RS02615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TPH_RS02620	COG0310	cobalt ion transport
TPH_RS02625	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
TPH_RS02635	COG1122	ATPase activity
TPH_RS02640	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TPH_RS02670	COG2099	Precorrin-6x reductase
TPH_RS02680	COG1492	cobalamin metabolic process
TPH_RS02695	COG1980	fructose-bisphosphate aldolase activity
TPH_RS02700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TPH_RS02725	COG2323	membrane
TPH_RS02730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPH_RS02775	COG2197	response regulator
TPH_RS02800	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
TPH_RS02805	COG1040	competence protein
TPH_RS02830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TPH_RS02835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TPH_RS02870	COG4786	Flagellar basal body rod
TPH_RS02870	COG1256	bacterial-type flagellum assembly
TPH_RS02885	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TPH_RS02895	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TPH_RS02900	COG1151	hydroxylamine reductase activity
TPH_RS02905	COG1381	Involved in DNA repair and RecF pathway recombination
TPH_RS02915	COG0752	glycyl-tRNA synthetase alpha subunit
TPH_RS02920	COG0751	glycine-tRNA ligase activity
TPH_RS02925	COG0517	IMP dehydrogenase activity
TPH_RS02930	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TPH_RS02935	COG0574	Belongs to the PEP-utilizing enzyme family
TPH_RS02935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPH_RS02950	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TPH_RS02955	COG0358	DNA primase activity
TPH_RS02960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TPH_RS02965	COG5012	cobalamin binding
TPH_RS02995	COG0285	dihydrofolate synthase activity
TPH_RS03000	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TPH_RS03010	COG0424	maF-like protein
TPH_RS03020	COG1077	Cell shape determining protein MreB Mrl
TPH_RS03025	COG1792	Involved in formation and maintenance of cell shape
TPH_RS03035	COG0768	penicillin binding
TPH_RS03040	COG0850	regulation of cytokinetic process
TPH_RS03045	COG2894	cell division
TPH_RS03050	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TPH_RS03055	COG0772	Belongs to the SEDS family
TPH_RS03080	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TPH_RS03110	COG0393	Putative heavy-metal-binding
TPH_RS03130	COG1595	DNA-templated transcription, initiation
TPH_RS03205	COG4372	Transposase
TPH_RS03240	COG0860	N-Acetylmuramoyl-L-alanine amidase
TPH_RS03245	COG1342	Belongs to the UPF0251 family
TPH_RS03260	COG1283	sodium-dependent phosphate transmembrane transporter activity
TPH_RS03270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TPH_RS03275	COG0653	protein targeting
TPH_RS03285	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TPH_RS03290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TPH_RS03295	COG3959	Transketolase, thiamine diphosphate binding domain
TPH_RS03300	COG3958	Transketolase
TPH_RS03305	COG2884	Cell division ATP-binding protein ftsE
TPH_RS03310	COG2177	Part of the ABC transporter FtsEX involved in
TPH_RS03315	COG0739	heme binding
TPH_RS03330	COG0793	Belongs to the peptidase S41A family
TPH_RS03330	COG3409	Peptidoglycan-binding domain 1 protein
TPH_RS03335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPH_RS03355	COG0556	nucleotide-excision repair
TPH_RS03360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TPH_RS03365	COG0322	excinuclease ABC activity
TPH_RS03370	COG0561	phosphatase activity
TPH_RS03375	COG0166	Belongs to the GPI family
TPH_RS03385	COG1660	Displays ATPase and GTPase activities
TPH_RS03390	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TPH_RS03395	COG1481	regulation of sporulation
TPH_RS03405	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TPH_RS03415	COG0126	phosphoglycerate kinase activity
TPH_RS03420	COG0149	triose-phosphate isomerase activity
TPH_RS03425	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TPH_RS03435	COG0148	phosphopyruvate hydratase activity
TPH_RS03440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TPH_RS03455	COG5012	cobalamin binding
TPH_RS03510	COG4303	Ethanolamine ammonia lyase large subunit
TPH_RS03515	COG4302	ethanolamine ammonia-lyase activity
TPH_RS03520	COG4816	utilization protein
TPH_RS03525	COG1454	alcohol dehydrogenase
TPH_RS03525	COG1012	belongs to the aldehyde dehydrogenase family
TPH_RS03535	COG4812	Cobalamin adenosyltransferase
TPH_RS03540	COG4820	ethanolamine utilization protein (EutJ)
TPH_RS03550	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
TPH_RS03555	COG4656	Part of a membrane complex involved in electron transport
TPH_RS03560	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TPH_RS03610	COG0557	exoribonuclease II activity
TPH_RS03615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TPH_RS03665	COG2088	sporulation resulting in formation of a cellular spore
TPH_RS03685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TPH_RS03700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TPH_RS03735	COG4974	Belongs to the 'phage' integrase family
TPH_RS03800	COG0739	heme binding
TPH_RS03860	COG2033	superoxide reductase activity
TPH_RS03890	COG2801	Transposase and inactivated derivatives
TPH_RS03915	COG3706	GGDEF domain
TPH_RS03945	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TPH_RS04005	COG2361	Protein of unknown function DUF86
TPH_RS04010	COG1773	rubredoxin
TPH_RS04010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TPH_RS04015	COG2033	superoxide reductase activity
TPH_RS04025	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TPH_RS04030	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TPH_RS04055	COG1793	dna ligase
TPH_RS04055	COG3285	dna ligase
TPH_RS04065	COG3942	CHAP domain
TPH_RS04065	COG1388	LysM domain
TPH_RS04080	COG1316	TRANSCRIPTIONal
TPH_RS04090	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TPH_RS04095	COG0438	transferase activity, transferring glycosyl groups
TPH_RS04100	COG0741	lytic transglycosylase activity
TPH_RS04105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TPH_RS04110	COG3852	Histidine kinase
TPH_RS04115	COG2204	response regulator
TPH_RS04125	COG2414	aldehyde ferredoxin oxidoreductase
TPH_RS04155	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TPH_RS04160	COG1606	tRNA processing
TPH_RS04175	COG1910	domain protein
TPH_RS04180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TPH_RS04185	COG0315	cyclic pyranopterin monophosphate synthase activity
TPH_RS04195	COG0521	Mo-molybdopterin cofactor biosynthetic process
TPH_RS04200	COG0459	protein refolding
TPH_RS04210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TPH_RS04215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TPH_RS04220	COG0519	Catalyzes the synthesis of GMP from XMP
TPH_RS04220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TPH_RS04225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TPH_RS04230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TPH_RS04235	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TPH_RS04240	COG0047	phosphoribosylformylglycinamidine synthase activity
TPH_RS04245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TPH_RS04250	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TPH_RS04255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TPH_RS04260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TPH_RS04265	COG0138	bifunctional purine biosynthesis protein purh
TPH_RS04285	COG3707	response regulator
TPH_RS04290	COG0067	glutamate synthase
TPH_RS04295	COG0069	glutamate synthase activity
TPH_RS04300	COG0493	'glutamate synthase
TPH_RS04300	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TPH_RS04315	COG1797	cobyrinic acid a,c-diamide synthase activity
TPH_RS04320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TPH_RS04320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TPH_RS04330	COG0367	asparagine synthase
TPH_RS04345	COG0347	Belongs to the P(II) protein family
TPH_RS04350	COG0347	Belongs to the P(II) protein family
TPH_RS04360	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TPH_RS04365	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TPH_RS04375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TPH_RS04390	COG0004	ammonium transporteR
TPH_RS04395	COG0347	Belongs to the P(II) protein family
TPH_RS04400	COG0697	spore germination
TPH_RS04405	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TPH_RS04420	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TPH_RS04425	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TPH_RS04430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TPH_RS04435	COG0131	Imidazoleglycerol-phosphate dehydratase
TPH_RS04440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TPH_RS04445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TPH_RS04450	COG0107	imidazoleglycerol-phosphate synthase activity
TPH_RS04455	COG0140	phosphoribosyl-ATP diphosphatase activity
TPH_RS04455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TPH_RS04465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TPH_RS04475	COG0517	IMP dehydrogenase activity
TPH_RS04475	COG0516	GMP reductase activity
TPH_RS04495	COG0154	amidase activity
TPH_RS04500	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPH_RS04505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TPH_RS04510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TPH_RS04515	COG0066	3-isopropylmalate dehydratase activity
TPH_RS04520	COG0473	3-isopropylmalate dehydrogenase activity
TPH_RS04535	COG0697	spore germination
TPH_RS04555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TPH_RS04560	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TPH_RS04570	COG5012	cobalamin binding
TPH_RS04575	COG1151	hydroxylamine reductase activity
TPH_RS04580	COG1959	2 iron, 2 sulfur cluster binding
TPH_RS04585	COG1543	Belongs to the glycosyl hydrolase 57 family
TPH_RS04600	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TPH_RS04605	COG0298	carbon dioxide binding
TPH_RS04610	COG0409	Hydrogenase expression formation protein
TPH_RS04615	COG0309	Hydrogenase expression formation protein (HypE)
TPH_RS04645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TPH_RS04660	COG1968	undecaprenyl-diphosphatase activity
TPH_RS04665	COG3464	Transposase
TPH_RS04695	COG0205	6-phosphofructokinase activity
TPH_RS04710	COG0719	Fe-S assembly protein
TPH_RS04740	COG0310	cobalt ion transport
TPH_RS04750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TPH_RS04760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TPH_RS04765	COG0287	Prephenate dehydrogenase
TPH_RS04790	COG1073	alpha beta
TPH_RS04805	COG1882	Formate acetyltransferase
TPH_RS04850	COG0840	transmembrane signaling receptor activity
TPH_RS04850	COG3290	protein histidine kinase activity
TPH_RS04885	COG3679	Belongs to the UPF0342 family
TPH_RS04890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TPH_RS04895	COG1122	ATPase activity
TPH_RS04905	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TPH_RS04910	COG0010	Belongs to the arginase family
TPH_RS04970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TPH_RS04975	COG1302	Protein conserved in bacteria
TPH_RS04985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TPH_RS05000	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TPH_RS05005	COG1573	uracil-dna glycosylase
TPH_RS05010	COG3464	Transposase
TPH_RS05015	COG0742	ribosomal rna small subunit methyltransferase
TPH_RS05020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TPH_RS05030	COG3314	Sporulation integral membrane protein YlbJ
TPH_RS05035	COG0280	phosphate acetyltransferase
TPH_RS05050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TPH_RS05060	COG0416	fatty acid biosynthetic process
TPH_RS05065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TPH_RS05070	COG0571	ribonuclease III activity
TPH_RS05075	COG2359	stage V sporulation protein S
TPH_RS05080	COG1196	nuclear chromosome segregation
TPH_RS05085	COG0552	protein localization to endoplasmic reticulum
TPH_RS05090	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TPH_RS05095	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TPH_RS05105	COG0402	S-adenosylhomocysteine deaminase activity
TPH_RS05110	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
TPH_RS05115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TPH_RS05120	COG0228	four-way junction DNA binding
TPH_RS05130	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TPH_RS05135	COG0336	Belongs to the RNA methyltransferase TrmD family
TPH_RS05140	COG0335	large ribosomal subunit rRNA binding
TPH_RS05150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TPH_RS05155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TPH_RS05165	COG2257	FlhB HrpN YscU SpaS Family
TPH_RS05170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TPH_RS05170	COG2199	diguanylate cyclase activity
TPH_RS05175	COG0792	nuclease activity
TPH_RS05180	COG0277	FAD linked oxidase domain protein
TPH_RS05185	COG0247	lactate metabolic process
TPH_RS05210	COG0560	Phosphoserine phosphatase
TPH_RS05230	COG3344	reverse transcriptase
TPH_RS05300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPH_RS05340	COG1725	Transcriptional regulator
TPH_RS05345	COG1131	(ABC) transporter
TPH_RS05355	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TPH_RS05360	COG0758	DNA mediated transformation
TPH_RS05365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TPH_RS05370	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TPH_RS05375	COG4974	Belongs to the 'phage' integrase family
TPH_RS05380	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TPH_RS05385	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TPH_RS05390	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
TPH_RS05400	COG1815	bacterial-type flagellum-dependent cell motility
TPH_RS05405	COG1558	bacterial-type flagellum-dependent cell motility
TPH_RS05410	COG1677	Flagellar hook-basal body complex protein FliE
TPH_RS05415	COG1766	The M ring may be actively involved in energy transduction
TPH_RS05420	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPH_RS05430	COG1157	protein secretion by the type III secretion system
TPH_RS05450	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TPH_RS05475	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPH_RS05480	COG1776	CheC inhibitor of MCP methylation
TPH_RS05480	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPH_RS05485	COG2201	protein-glutamate methylesterase activity
TPH_RS05495	COG1338	Plays a role in the flagellum-specific transport system
TPH_RS05500	COG1987	bacterial-type flagellum assembly
TPH_RS05505	COG1684	flagellar biosynthetic protein fliR
TPH_RS05510	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPH_RS05515	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPH_RS05520	COG1419	protein localization to endoplasmic reticulum
TPH_RS05535	COG2201	protein-glutamate methylesterase activity
TPH_RS05540	COG0643	Histidine kinase
TPH_RS05540	COG2198	Histidine kinase
TPH_RS05545	COG1776	CheC inhibitor of MCP methylation
TPH_RS05550	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TPH_RS05560	COG1191	sigma factor activity
TPH_RS05580	COG0052	Belongs to the universal ribosomal protein uS2 family
TPH_RS05585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TPH_RS05590	COG0528	UMP kinase activity
TPH_RS05595	COG0233	cytoplasmic translational termination
TPH_RS05615	COG4589	Belongs to the CDS family
TPH_RS05620	COG0628	permease
TPH_RS05625	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TPH_RS05630	COG0750	zinc metalloprotease
TPH_RS05635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TPH_RS05640	COG0442	prolyl-tRNA aminoacylation
TPH_RS05645	COG0779	Required for maturation of 30S ribosomal subunits
TPH_RS05650	COG0195	Participates in both transcription termination and antitermination
TPH_RS05655	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TPH_RS05665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TPH_RS05665	COG3064	Membrane
TPH_RS05665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TPH_RS05665	COG3064	Membrane
TPH_RS05670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TPH_RS05675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TPH_RS05680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TPH_RS05685	COG0196	riboflavin kinase activity
TPH_RS05690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TPH_RS05695	COG1185	polyribonucleotide nucleotidyltransferase activity
TPH_RS05700	COG0726	polysaccharide deacetylase
TPH_RS05710	COG0612	Peptidase, M16
TPH_RS05715	COG1873	PFAM PRC-barrel domain
TPH_RS05725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TPH_RS05730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TPH_RS05735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TPH_RS05740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TPH_RS05745	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TPH_RS05765	COG0740	serine-type endopeptidase activity
TPH_RS05770	COG1674	ftsk spoiiie
TPH_RS05775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TPH_RS05775	COG1522	sequence-specific DNA binding
TPH_RS05780	COG1426	Protein conserved in bacteria
TPH_RS05785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPH_RS05795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPH_RS05800	COG1546	Belongs to the CinA family
TPH_RS05800	COG1058	Belongs to the CinA family
TPH_RS05810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TPH_RS05815	COG1418	mRNA catabolic process
TPH_RS05825	COG1692	metallophosphoesterase
TPH_RS05830	COG2359	stage V sporulation protein S
TPH_RS05845	COG0791	NLP P60 protein
TPH_RS05865	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
TPH_RS05870	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TPH_RS05875	COG0406	alpha-ribazole phosphatase activity
TPH_RS05880	COG0517	IMP dehydrogenase activity
TPH_RS05880	COG0516	GMP reductase activity
TPH_RS05885	COG0542	response to heat
TPH_RS05895	COG1285	pathogenesis
TPH_RS05900	COG3344	reverse transcriptase
TPH_RS05915	COG0297	glycogen (starch) synthase activity
TPH_RS05920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TPH_RS06045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TPH_RS06135	COG1192	Involved in chromosome partitioning
TPH_RS06150	COG3547	Transposase (IS116 IS110 IS902 family)
TPH_RS06165	COG1131	(ABC) transporter
TPH_RS06175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TPH_RS06180	COG0632	four-way junction helicase activity
TPH_RS06190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TPH_RS06205	COG2247	cell wall binding repeat
TPH_RS06205	COG2385	sporulation resulting in formation of a cellular spore
TPH_RS06215	COG0343	queuine tRNA-ribosyltransferase activity
TPH_RS06225	COG2337	Toxic component of a toxin-antitoxin (TA) module
TPH_RS06235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPH_RS06240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPH_RS06245	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TPH_RS06250	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TPH_RS06260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TPH_RS06265	COG1490	D-aminoacyl-tRNA deacylase activity
TPH_RS06270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPH_RS06275	COG0124	histidyl-tRNA synthetase
TPH_RS06280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TPH_RS06285	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TPH_RS06295	COG2234	aminopeptidase activity
TPH_RS06305	COG2001	Belongs to the MraZ family
TPH_RS06310	COG0275	rRNA processing
TPH_RS06325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TPH_RS06330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TPH_RS06335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPH_RS06340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TPH_RS06345	COG0772	Belongs to the SEDS family
TPH_RS06350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TPH_RS06355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TPH_RS06360	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TPH_RS06365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TPH_RS06370	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TPH_RS06380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TPH_RS06390	COG1191	sigma factor activity
TPH_RS06395	COG1191	sigma factor activity
TPH_RS06405	COG1873	PFAM PRC-barrel domain
TPH_RS06410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TPH_RS06420	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TPH_RS06445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TPH_RS06450	COG1799	cell septum assembly
TPH_RS06455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TPH_RS06460	COG0762	integral membrane protein
TPH_RS06465	COG1872	DUF167
TPH_RS06475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TPH_RS06480	COG3830	Belongs to the UPF0237 family
TPH_RS06485	COG2848	UPF0210 protein
TPH_RS06500	COG0438	transferase activity, transferring glycosyl groups
TPH_RS06505	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TPH_RS06510	COG0564	pseudouridine synthase activity
TPH_RS06515	COG0174	glutamine synthetase
TPH_RS06540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TPH_RS06545	COG0037	tRNA processing
TPH_RS06550	COG3191	aminopeptidase activity
TPH_RS06585	COG3464	Transposase
TPH_RS06600	COG1181	Belongs to the D-alanine--D-alanine ligase family
TPH_RS06615	COG0037	tRNA processing
TPH_RS06640	COG2249	NAD(P)H dehydrogenase (quinone) activity
TPH_RS06650	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TPH_RS06650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TPH_RS06670	COG0730	response to heat
TPH_RS06675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TPH_RS06680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TPH_RS06685	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TPH_RS06690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TPH_RS06695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TPH_RS06700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TPH_RS06700	COG0072	phenylalanine-tRNA ligase activity
TPH_RS06705	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TPH_RS06710	COG1796	DNA polymerase
TPH_RS06710	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TPH_RS06720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TPH_RS06725	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TPH_RS06730	COG1993	acr, cog1993
TPH_RS06735	COG0826	peptidase U32
TPH_RS06740	COG1193	negative regulation of DNA recombination
TPH_RS06745	COG2135	peptidase activity
TPH_RS06750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TPH_RS06750	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TPH_RS06770	COG0432	Pfam Uncharacterised protein family UPF0047
TPH_RS06790	COG1376	ErfK ybiS ycfS ynhG family protein
TPH_RS06820	COG1053	succinate dehydrogenase
TPH_RS06825	COG3547	Transposase (IS116 IS110 IS902 family)
TPH_RS06850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TPH_RS06860	COG0825	malonyl-CoA metabolic process
TPH_RS06865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TPH_RS06870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TPH_RS06875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TPH_RS06880	COG1028	Short-chain dehydrogenase reductase Sdr
TPH_RS06885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TPH_RS06895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TPH_RS06905	COG0464	growth
TPH_RS06910	COG1174	glycine betaine transport
TPH_RS06915	COG1116	anion transmembrane transporter activity
TPH_RS06920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TPH_RS06920	COG1116	anion transmembrane transporter activity
TPH_RS06930	COG1923	regulation of RNA biosynthetic process
TPH_RS06935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TPH_RS06940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TPH_RS06955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TPH_RS06965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPH_RS07010	COG0622	Phosphoesterase
TPH_RS07015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TPH_RS07020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TPH_RS07020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TPH_RS07025	COG0307	riboflavin synthase, alpha
TPH_RS07030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TPH_RS07030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TPH_RS07105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TPH_RS07110	COG1162	GTPase activity
TPH_RS07115	COG2815	serine threonine protein kinase
TPH_RS07115	COG0515	serine threonine protein kinase
TPH_RS07125	COG0772	Belongs to the SEDS family
TPH_RS07135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TPH_RS07135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TPH_RS07140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TPH_RS07145	COG0242	peptide deformylase activity
TPH_RS07150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TPH_RS07155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TPH_RS07160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TPH_RS07165	COG1758	RNA polymerase activity
TPH_RS07170	COG0194	GDP metabolic process
TPH_RS07175	COG2052	Domain of unknown function (DUF370)
TPH_RS07180	COG1561	YicC-like family, N-terminal region
TPH_RS07185	COG0436	Aminotransferase
TPH_RS07190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TPH_RS07205	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TPH_RS07210	COG0284	orotidine-5'-phosphate decarboxylase activity
TPH_RS07215	COG0167	dihydroorotate dehydrogenase activity
TPH_RS07220	COG0543	2 iron, 2 sulfur cluster binding
TPH_RS07225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TPH_RS07230	COG0505	Belongs to the CarA family
TPH_RS07235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TPH_RS07240	COG0540	Belongs to the ATCase OTCase family
TPH_RS07245	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TPH_RS07260	COG2217	Heavy metal translocating P-type atpase
TPH_RS07355	COG3290	protein histidine kinase activity
TPH_RS07425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPH_RS07460	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TPH_RS07465	COG0302	gtp cyclohydrolase
TPH_RS07475	COG0735	belongs to the Fur family
TPH_RS07480	COG0745	RESPONSE REGULATOR receiver
TPH_RS07505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TPH_RS07510	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TPH_RS07515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TPH_RS07520	COG3935	DnaD domain protein
TPH_RS07530	COG0436	Aminotransferase
TPH_RS07595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TPH_RS07600	COG1307	EDD domain protein, DegV family
TPH_RS07620	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TPH_RS07625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TPH_RS07630	COG1522	sequence-specific DNA binding
TPH_RS07635	COG0535	radical SAM domain protein
TPH_RS07640	COG0113	porphobilinogen synthase activity
TPH_RS07645	COG0535	radical SAM domain protein
TPH_RS07655	COG0181	hydroxymethylbilane synthase activity
TPH_RS07660	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TPH_RS07665	COG1648	precorrin-2 dehydrogenase activity
TPH_RS07665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TPH_RS07680	COG0437	4 iron, 4 sulfur cluster binding
TPH_RS07695	COG0805	protein transport
TPH_RS07705	COG0163	prenyltransferase activity
TPH_RS07710	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TPH_RS07720	COG2048	Heterodisulfide reductase, subunit B
TPH_RS07730	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TPH_RS07755	COG0083	homoserine kinase activity
TPH_RS07760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TPH_RS07765	COG0460	homoserine dehydrogenase
TPH_RS07770	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TPH_RS07775	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TPH_RS07780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TPH_RS07830	COG0539	negative regulation of cytoplasmic translation
TPH_RS07830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TPH_RS07840	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TPH_RS07845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TPH_RS07850	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TPH_RS07880	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TPH_RS07885	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TPH_RS07890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPH_RS07895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPH_RS07900	COG1187	pseudouridine synthase activity
TPH_RS07910	COG0700	Nucleoside recognition
TPH_RS07915	COG2715	membrane protein required for spore maturation
TPH_RS07920	COG1686	Belongs to the peptidase S11 family
TPH_RS07925	COG3874	Sporulation protein YtfJ
TPH_RS07935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TPH_RS07945	COG0180	Tryptophanyl-tRNA synthetase
TPH_RS07950	COG1994	Peptidase M50
TPH_RS07955	COG0019	diaminopimelate decarboxylase activity
TPH_RS07960	COG1924	4 iron, 4 sulfur cluster binding
TPH_RS07980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TPH_RS07995	COG1191	sigma factor activity
TPH_RS08000	COG2172	sigma factor antagonist activity
TPH_RS08005	COG1366	Belongs to the anti-sigma-factor antagonist family
TPH_RS08010	COG1686	Belongs to the peptidase S11 family
TPH_RS08020	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TPH_RS08025	COG4974	Belongs to the 'phage' integrase family
TPH_RS08035	COG1300	Membrane
TPH_RS08045	COG1379	DNA repair
TPH_RS08060	COG2195	Cleaves the N-terminal amino acid of tripeptides
TPH_RS08065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPH_RS08070	COG0463	Glycosyl transferase, family 2
TPH_RS08085	COG0745	RESPONSE REGULATOR receiver
TPH_RS08090	COG0750	zinc metalloprotease
TPH_RS08095	COG0497	DNA recombination
TPH_RS08100	COG1438	arginine binding
TPH_RS08105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TPH_RS08110	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TPH_RS08115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TPH_RS08135	COG1570	exodeoxyribonuclease VII activity
TPH_RS08140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TPH_RS08145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TPH_RS08150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TPH_RS08165	COG1302	Protein conserved in bacteria
TPH_RS08170	COG0439	Biotin carboxylase
TPH_RS08215	COG3854	ATPases associated with a variety of cellular activities
TPH_RS08225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TPH_RS08230	COG0006	proline dipeptidase activity
TPH_RS08235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TPH_RS08240	COG0312	modulator of DNA gyrase
TPH_RS08245	COG0312	modulator of DNA gyrase
TPH_RS08255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TPH_RS08270	COG0849	cell division
TPH_RS08295	COG2165	general secretion pathway protein
TPH_RS08300	COG1459	type II secretion system
TPH_RS08310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TPH_RS08320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TPH_RS08325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TPH_RS08330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TPH_RS08335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TPH_RS08340	COG2201	protein-glutamate methylesterase activity
TPH_RS08345	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TPH_RS08375	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TPH_RS08400	COG0768	penicillin binding
TPH_RS08405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TPH_RS08410	COG2720	vancomycin resistance protein
TPH_RS08415	COG3906	Belongs to the UPF0473 family
TPH_RS08420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TPH_RS08425	COG0667	Aldo Keto reductase
TPH_RS08430	COG4472	Bacterial protein of unknown function (DUF965)
TPH_RS08435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TPH_RS08450	COG0433	COG0433 Predicted ATPase
TPH_RS08460	COG0515	serine threonine protein kinase
TPH_RS08460	COG2815	serine threonine protein kinase
TPH_RS08480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TPH_RS08495	COG0778	Nitroreductase
TPH_RS08500	COG4608	Belongs to the ABC transporter superfamily
TPH_RS08505	COG0444	Belongs to the ABC transporter superfamily
TPH_RS08510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPH_RS08515	COG0601	transmembrane transport
TPH_RS08520	COG0747	negative chemotaxis
TPH_RS08535	COG1760	l-serine dehydratase
TPH_RS08540	COG1760	l-serine dehydratase
TPH_RS08545	COG4475	Protein of unknown function (DUF436)
TPH_RS08550	COG0095	Lipoate-protein ligase
TPH_RS08555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TPH_RS08560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TPH_RS08565	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TPH_RS08575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TPH_RS08590	COG0628	permease
TPH_RS08610	COG0482	sulfurtransferase activity
TPH_RS08615	COG1104	cysteine desulfurase activity
TPH_RS08625	COG3118	belongs to the thioredoxin family
TPH_RS08640	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TPH_RS08650	COG0445	tRNA wobble uridine modification
TPH_RS08665	COG3290	protein histidine kinase activity
TPH_RS08700	COG3328	transposase activity
TPH_RS08775	COG3464	Transposase
TPH_RS08780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TPH_RS08805	COG0446	pyridine nucleotide-disulphide oxidoreductase
TPH_RS08845	COG0352	thiamine-phosphate diphosphorylase activity
TPH_RS08850	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TPH_RS08860	COG0351	phosphomethylpyrimidine kinase
TPH_RS08860	COG0352	thiamine-phosphate diphosphorylase activity
TPH_RS08870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TPH_RS08875	COG0352	thiamine-phosphate diphosphorylase activity
TPH_RS08885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TPH_RS08890	COG2022	thiamine diphosphate biosynthetic process
TPH_RS08905	COG2223	nitrite transmembrane transporter activity
TPH_RS08920	COG0601	transmembrane transport
TPH_RS08925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPH_RS08935	COG1104	cysteine desulfurase activity
TPH_RS08945	COG0798	PFAM Bile acid sodium symporter
TPH_RS08970	COG4166	transmembrane transport
TPH_RS08980	COG1196	nuclear chromosome segregation
TPH_RS08980	COG0741	lytic transglycosylase activity
TPH_RS08980	COG0739	heme binding
TPH_RS08985	COG0237	dephospho-CoA kinase activity
TPH_RS08995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TPH_RS09005	COG2843	Capsule synthesis protein
TPH_RS09015	COG0217	transcriptional regulatory protein
TPH_RS09020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TPH_RS09045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TPH_RS09060	COG1335	isochorismatase
TPH_RS09090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TPH_RS09115	COG4120	Belongs to the binding-protein-dependent transport system permease family
TPH_RS09135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TPH_RS09140	COG2384	SAM-dependent methyltransferase
TPH_RS09145	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TPH_RS09160	COG3383	formate dehydrogenase (NAD+) activity
TPH_RS09200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TPH_RS09210	COG0456	acetyltransferase
TPH_RS09215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TPH_RS09220	COG0802	atpase or kinase
TPH_RS09225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TPH_RS09230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TPH_RS09230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TPH_RS09235	COG0736	holo-[acyl-carrier-protein] synthase activity
TPH_RS09245	COG0835	chemotaxis
TPH_RS09250	COG0012	GTP binding
TPH_RS09255	COG0667	Aldo Keto reductase
TPH_RS09260	COG1115	amino acid carrier protein
TPH_RS09270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TPH_RS09275	COG1307	EDD domain protein, DegV family
TPH_RS09280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPH_RS09285	COG0546	phosphoglycolate phosphatase activity
TPH_RS09290	COG1757	Na H antiporter
TPH_RS09310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TPH_RS09335	COG1924	4 iron, 4 sulfur cluster binding
TPH_RS09370	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TPH_RS09375	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TPH_RS09395	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TPH_RS09430	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TPH_RS09435	COG1518	maintenance of DNA repeat elements
TPH_RS09485	COG0318	PFAM AMP-dependent synthetase and ligase
TPH_RS09500	COG1132	(ABC) transporter
TPH_RS09505	COG1132	(ABC) transporter
TPH_RS09510	COG1846	Transcriptional regulator
TPH_RS09515	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TPH_RS09525	COG0640	Transcriptional regulator
TPH_RS09545	COG1104	cysteine desulfurase activity
TPH_RS09550	COG0822	iron-sulfur transferase activity
TPH_RS09560	COG0425	Belongs to the sulfur carrier protein TusA family
TPH_RS09645	COG2337	Toxic component of a toxin-antitoxin (TA) module
TPH_RS09695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPH_RS09730	COG0247	lactate metabolic process
TPH_RS09740	COG0509	glycine decarboxylation via glycine cleavage system
TPH_RS09750	COG0508	dehydrogenase complex catalyzes the overall conversion of
TPH_RS09755	COG3199	ATP-NAD kinase
TPH_RS09760	COG0022	dehydrogenase e1 component
TPH_RS09765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TPH_RS09770	COG1063	alcohol dehydrogenase
TPH_RS09800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TPH_RS09805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPH_RS09830	COG3856	small basic protein
TPH_RS09840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TPH_RS09845	COG0473	3-isopropylmalate dehydrogenase activity
TPH_RS09850	COG0066	3-isopropylmalate dehydratase activity
TPH_RS09855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TPH_RS09860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TPH_RS09865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TPH_RS09870	COG0440	acetolactate synthase activity
TPH_RS09875	COG0028	Belongs to the TPP enzyme family
TPH_RS09880	COG0129	dihydroxy-acid dehydratase activity
TPH_RS09885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TPH_RS09895	COG1773	rubredoxin
TPH_RS09895	COG1592	Rubrerythrin
TPH_RS09905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TPH_RS09935	COG3464	Transposase
TPH_RS09975	COG3547	Transposase (IS116 IS110 IS902 family)
TPH_RS09985	COG5012	cobalamin binding
TPH_RS09995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TPH_RS10005	COG1732	Glycine betaine
TPH_RS10010	COG1125	glycine betaine transport
TPH_RS10010	COG0517	IMP dehydrogenase activity
TPH_RS10015	COG1174	glycine betaine transport
TPH_RS10020	COG0438	transferase activity, transferring glycosyl groups
TPH_RS10045	COG3799	methylaspartate ammonia-lyase activity
TPH_RS10050	COG4865	methylaspartate mutase activity
TPH_RS10060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TPH_RS10065	COG5012	cobalamin binding
TPH_RS10090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TPH_RS10095	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TPH_RS10100	COG2414	aldehyde ferredoxin oxidoreductase
TPH_RS10120	COG1174	glycine betaine transport
TPH_RS10135	COG3829	transcription factor binding
TPH_RS10140	COG3404	Formiminotransferase-cyclodeaminase
TPH_RS10150	COG1228	amidohydrolase
TPH_RS10155	COG2986	histidine ammonia-lyase
TPH_RS10160	COG0577	efflux transmembrane transporter activity
TPH_RS10165	COG4591	ABC-type transport system involved in lipoprotein release permease component
TPH_RS10165	COG1136	(ABC) transporter
TPH_RS10180	COG0492	ferredoxin-NADP+ reductase activity
TPH_RS10195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TPH_RS10200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TPH_RS10205	COG0512	Glutamine amidotransferase of anthranilate synthase
TPH_RS10210	COG1959	2 iron, 2 sulfur cluster binding
TPH_RS10225	COG4753	response regulator
TPH_RS10225	COG2207	Transcriptional regulator
TPH_RS10230	COG0326	Molecular chaperone. Has ATPase activity
TPH_RS10240	COG2972	Histidine kinase
TPH_RS10245	COG1937	Protein conserved in bacteria
TPH_RS10255	COG2217	Heavy metal translocating P-type atpase
TPH_RS10310	COG1213	nucleotidyl transferase
TPH_RS10310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TPH_RS10315	COG1260	myo-inositol-1-phosphate synthase
TPH_RS10325	COG2337	Toxic component of a toxin-antitoxin (TA) module
TPH_RS10330	COG2336	PFAM SpoVT AbrB
TPH_RS10340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TPH_RS10365	COG3546	catalase activity
TPH_RS10390	COG1595	DNA-templated transcription, initiation
TPH_RS10410	COG2076	Multidrug Resistance protein
TPH_RS10415	COG1268	BioY protein
TPH_RS10420	COG1122	ATPase activity
TPH_RS10425	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TPH_RS10440	COG0537	adenosine 5'-monophosphoramidase activity
TPH_RS10445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPH_RS10450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TPH_RS10455	COG0484	heat shock protein binding
TPH_RS10460	COG0443	Heat shock 70 kDa protein
TPH_RS10465	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TPH_RS10470	COG1420	regulation of RNA biosynthetic process
TPH_RS10475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TPH_RS10480	COG0481	GTPase activity
TPH_RS10485	COG0728	peptidoglycan biosynthetic process
TPH_RS10525	COG0268	Binds directly to 16S ribosomal RNA
TPH_RS10545	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TPH_RS10550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPH_RS10555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TPH_RS10575	COG3260	NADH ubiquinone oxidoreductase 20
TPH_RS10585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TPH_RS10585	COG2111	Na H antiporter
TPH_RS10595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TPH_RS10600	COG0495	leucyl-tRNA aminoacylation
TPH_RS10630	COG1305	Transglutaminase-like
TPH_RS10680	COG2197	response regulator
TPH_RS10690	COG0799	negative regulation of ribosome biogenesis
TPH_RS10695	COG1713	HD superfamily hydrolase involved in NAD metabolism
TPH_RS10705	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TPH_RS10710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TPH_RS10715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TPH_RS10730	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TPH_RS10760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TPH_RS10765	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TPH_RS10780	COG0789	Transcriptional regulator
TPH_RS10795	COG0656	L-ascorbic acid biosynthetic process
TPH_RS10800	COG1979	alcohol dehydrogenase
TPH_RS10850	COG2814	Major facilitator Superfamily
TPH_RS10870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TPH_RS10875	COG4372	Transposase
TPH_RS10915	COG0582	viral genome integration into host DNA
TPH_RS10980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TPH_RS10985	COG0765	amino acid transport
TPH_RS10990	COG1126	abc transporter atp-binding protein
TPH_RS11005	COG1516	flagellar protein fliS
TPH_RS11015	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TPH_RS11025	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TPH_RS11040	COG1509	lysine 2,3-aminomutase activity
TPH_RS11060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TPH_RS11065	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TPH_RS11070	COG2959	enzyme of heme biosynthesis
TPH_RS11080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TPH_RS11085	COG0826	peptidase U32
TPH_RS11090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TPH_RS11095	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TPH_RS11105	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TPH_RS11125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPH_RS11130	COG1121	(ABC) transporter
TPH_RS11135	COG0803	Belongs to the bacterial solute-binding protein 9 family
TPH_RS11135	COG3443	Belongs to the bacterial solute-binding protein 9 family
TPH_RS11140	COG0735	belongs to the Fur family
TPH_RS11150	COG1811	Na channel or pump
TPH_RS11160	COG3290	protein histidine kinase activity
TPH_RS11185	COG0489	protein tyrosine kinase activity
TPH_RS11225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPH_RS11235	COG0731	radical SAM domain protein
TPH_RS11235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TPH_RS11240	COG1464	Belongs to the NlpA lipoprotein family
TPH_RS11245	COG2011	ABC-type metal ion transport system permease component
TPH_RS11250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TPH_RS11255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TPH_RS11260	COG2911	Protein conserved in bacteria
TPH_RS11260	COG3266	domain, Protein
TPH_RS11260	COG1361	Conserved repeat domain
TPH_RS11265	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TPH_RS11275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TPH_RS11280	COG0295	cytidine deaminase activity
TPH_RS11285	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TPH_RS11290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TPH_RS11295	COG1480	7TM receptor with intracellular HD hydrolase
TPH_RS11300	COG1702	phosphate starvation-inducible protein PhoH
TPH_RS11315	COG1610	YqeY-like protein
TPH_RS11320	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TPH_RS11345	COG0617	tRNA 3'-terminal CCA addition
TPH_RS11355	COG2333	competence protein COMEC
TPH_RS11355	COG0658	competence protein
TPH_RS11415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TPH_RS11435	COG5632	N-Acetylmuramoyl-L-alanine amidase
TPH_RS11435	COG3409	Peptidoglycan-binding domain 1 protein
TPH_RS11445	COG0726	polysaccharide deacetylase
TPH_RS11505	COG0740	serine-type endopeptidase activity
TPH_RS11510	COG4695	Portal protein
TPH_RS11520	COG4626	Terminase
TPH_RS11520	COG1802	Transcriptional regulator
TPH_RS11620	COG1592	Rubrerythrin
TPH_RS11660	COG0822	iron-sulfur transferase activity
TPH_RS11665	COG1342	Belongs to the UPF0251 family
TPH_RS11700	COG3842	ATPase activity
TPH_RS11715	COG1136	(ABC) transporter
TPH_RS11715	COG0577	efflux transmembrane transporter activity
TPH_RS11720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TPH_RS11725	COG1136	(ABC) transporter
TPH_RS11740	COG0745	RESPONSE REGULATOR receiver
TPH_RS11745	COG2205	protein histidine kinase activity
TPH_RS11745	COG2770	Histidine kinase
TPH_RS11760	COG1136	(ABC) transporter
TPH_RS11825	COG1690	Belongs to the RtcB family
TPH_RS11840	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TPH_RS11860	COG1304	FMN binding
TPH_RS11890	COG0697	spore germination
TPH_RS11905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TPH_RS11910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TPH_RS11915	COG0167	dihydroorotate dehydrogenase activity
TPH_RS11920	COG1802	Transcriptional regulator
TPH_RS11935	COG0473	3-isopropylmalate dehydrogenase activity
TPH_RS11935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TPH_RS11940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TPH_RS11945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TPH_RS11945	COG0473	3-isopropylmalate dehydrogenase activity
TPH_RS11950	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TPH_RS11955	COG0167	dihydroorotate dehydrogenase activity
TPH_RS11975	COG2508	Transcriptional regulator
TPH_RS11975	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
TPH_RS11980	COG3976	FMN-binding domain protein
TPH_RS11980	COG1053	succinate dehydrogenase
TPH_RS11980	COG0431	NADPH-dependent FMN reductase
TPH_RS11985	COG2155	Conserved Protein
TPH_RS12000	COG2337	Toxic component of a toxin-antitoxin (TA) module
TPH_RS12040	COG3547	Transposase (IS116 IS110 IS902 family)
TPH_RS12050	COG3547	Transposase (IS116 IS110 IS902 family)
TPH_RS12055	COG4372	Transposase
TPH_RS12085	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TPH_RS12090	COG1518	maintenance of DNA repeat elements
TPH_RS12140	COG1337	RAMP superfamily
TPH_RS12165	COG1337	RAMP superfamily
TPH_RS12210	COG0328	RNA-DNA hybrid ribonuclease activity
TPH_RS12230	COG2323	membrane
TPH_RS12245	COG2252	PERMEase
TPH_RS12280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TPH_RS12300	COG0842	Transport permease protein
TPH_RS12305	COG1131	(ABC) transporter
TPH_RS12310	COG1131	(ABC) transporter
TPH_RS12315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TPH_RS12335	COG1278	Cold shock
TPH_RS12380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TPH_RS12390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPH_RS12395	COG0601	transmembrane transport
TPH_RS12425	COG2814	Major facilitator Superfamily
TPH_RS12430	COG0535	radical SAM domain protein
TPH_RS12435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TPH_RS12460	COG4608	Belongs to the ABC transporter superfamily
TPH_RS12465	COG0444	Belongs to the ABC transporter superfamily
TPH_RS12485	COG0747	negative chemotaxis
TPH_RS12490	COG4608	Belongs to the ABC transporter superfamily
TPH_RS12500	COG1131	(ABC) transporter
TPH_RS12510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TPH_RS12535	COG4608	Belongs to the ABC transporter superfamily
TPH_RS12555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPH_RS12560	COG0601	transmembrane transport
TPH_RS12580	COG1199	ATP-dependent helicase activity
TPH_RS12600	COG0515	serine threonine protein kinase
TPH_RS12600	COG2815	serine threonine protein kinase
TPH_RS12605	COG0165	Argininosuccinate lyase
TPH_RS12610	COG0137	argininosuccinate synthase activity
TPH_RS12615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TPH_RS12620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TPH_RS12625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TPH_RS12630	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TPH_RS12635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TPH_RS12645	COG2078	PFAM AMMECR1 domain protein
TPH_RS12645	COG3885	ferrous iron binding
TPH_RS12655	COG0860	N-Acetylmuramoyl-L-alanine amidase
TPH_RS12665	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TPH_RS12670	COG0101	tRNA pseudouridine synthase activity
TPH_RS12675	COG0203	ribosomal protein L17
TPH_RS12680	COG0202	RNA polymerase activity
TPH_RS12685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TPH_RS12690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TPH_RS12695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TPH_RS12700	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TPH_RS12705	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TPH_RS12720	COG0563	adenylate kinase activity
TPH_RS12725	COG0201	protein transport
TPH_RS12730	COG0200	Binds to the 23S rRNA
TPH_RS12735	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TPH_RS12740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TPH_RS12745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TPH_RS12750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TPH_RS12755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TPH_RS12760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TPH_RS12765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TPH_RS12770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TPH_RS12775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TPH_RS12780	COG0255	Belongs to the universal ribosomal protein uL29 family
TPH_RS12785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TPH_RS12790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TPH_RS12800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TPH_RS12805	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TPH_RS12810	COG0089	rRNA binding
TPH_RS12815	COG0088	Forms part of the polypeptide exit tunnel
TPH_RS12820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TPH_RS12825	COG0051	transcription antitermination factor activity, RNA binding
TPH_RS12830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TPH_RS12835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPH_RS12840	COG0049	tRNA binding
TPH_RS12845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TPH_RS12850	COG1358	cellular component organization or biogenesis
TPH_RS12855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TPH_RS12860	COG0085	RNA polymerase activity
TPH_RS12895	COG3464	Transposase
TPH_RS12910	COG0222	ribosome binding
TPH_RS12915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TPH_RS12920	COG0081	regulation of translation
TPH_RS12925	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TPH_RS12930	COG0250	Participates in transcription elongation, termination and antitermination
TPH_RS12940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TPH_RS12985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TPH_RS12995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TPH_RS12995	COG5322	oxidoreductase activity
TPH_RS13020	COG3383	formate dehydrogenase (NAD+) activity
TPH_RS13025	COG3383	formate dehydrogenase (NAD+) activity
TPH_RS13030	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TPH_RS13035	COG0651	ATP synthesis coupled electron transport
TPH_RS13040	COG0650	Formate hydrogenlyase subunit 4
TPH_RS13045	COG4237	Hydrogenase 4 membrane
TPH_RS13050	COG0651	ATP synthesis coupled electron transport
TPH_RS13060	COG3261	NADH dehydrogenase
TPH_RS13060	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TPH_RS13065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TPH_RS13070	COG3260	NADH ubiquinone oxidoreductase 20
TPH_RS13080	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TPH_RS13085	COG0588	phosphoglycerate mutase activity
TPH_RS13090	COG1910	domain protein
TPH_RS13100	COG0725	ABC transporter, periplasmic molybdate-binding protein
TPH_RS13105	COG4149	molybdate abc transporter
TPH_RS13110	COG3842	ATPase activity
TPH_RS13115	COG1028	Short-chain dehydrogenase reductase Sdr
TPH_RS13120	COG1640	4-alpha-glucanotransferase
TPH_RS13125	COG0438	transferase activity, transferring glycosyl groups
TPH_RS13140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TPH_RS13150	COG0133	tryptophan synthase activity
TPH_RS13155	COG0135	phosphoribosylanthranilate isomerase activity
TPH_RS13160	COG0134	indole-3-glycerol-phosphate synthase activity
TPH_RS13165	COG0512	Glutamine amidotransferase of anthranilate synthase
TPH_RS13165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TPH_RS13175	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TPH_RS13180	COG0586	Pfam SNARE associated Golgi protein
TPH_RS13190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TPH_RS13210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TPH_RS13215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TPH_RS13220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TPH_RS13235	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TPH_RS13250	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TPH_RS13260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TPH_RS13265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TPH_RS13270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TPH_RS13280	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TPH_RS13285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TPH_RS13290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TPH_RS13295	COG1418	mRNA catabolic process
TPH_RS13300	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TPH_RS13305	COG0105	UTP biosynthetic process
TPH_RS13315	COG0037	tRNA processing
TPH_RS13340	COG1388	LysM domain
TPH_RS13340	COG3858	chitin binding
TPH_RS13350	COG0375	protein maturation
TPH_RS13365	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
TPH_RS13380	COG0248	Ppx GppA phosphatase
TPH_RS13405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TPH_RS13410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TPH_RS13415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TPH_RS13420	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TPH_RS13440	COG3829	transcription factor binding
TPH_RS13470	COG4786	Flagellar basal body rod
TPH_RS13480	COG1609	Transcriptional regulator
TPH_RS13490	COG5577	PFAM Coat F domain
TPH_RS13495	COG2385	sporulation resulting in formation of a cellular spore
TPH_RS13505	COG1725	Transcriptional regulator
TPH_RS13540	COG3383	formate dehydrogenase (NAD+) activity
TPH_RS13550	COG0303	'Molybdopterin
TPH_RS13560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TPH_RS13575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TPH_RS13580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TPH_RS13585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TPH_RS13590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TPH_RS13595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TPH_RS13600	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TPH_RS13605	COG0356	it plays a direct role in the translocation of protons across the membrane
TPH_RS13620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TPH_RS13635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TPH_RS13640	COG0698	ribose 5-phosphate isomerase
TPH_RS13650	COG1971	Probably functions as a manganese efflux pump
TPH_RS13655	COG0009	L-threonylcarbamoyladenylate synthase
TPH_RS13665	COG2890	protein-(glutamine-N5) methyltransferase activity
TPH_RS13670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TPH_RS13675	COG3872	metal-dependent enzyme
TPH_RS13680	COG0254	rRNA binding
TPH_RS13685	COG2985	domain, Protein
TPH_RS13685	COG0569	domain protein
TPH_RS13695	COG0281	malic enzyme
TPH_RS13700	COG3875	lactate racemase activity
TPH_RS13725	COG5012	cobalamin binding
TPH_RS13740	COG5012	cobalamin binding
TPH_RS13770	COG5012	cobalamin binding
TPH_RS13790	COG0739	heme binding
TPH_RS13795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TPH_RS13800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TPH_RS13815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TPH_RS13825	COG0504	CTP synthase activity
TPH_RS13830	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TPH_RS13840	COG5002	protein histidine kinase activity
TPH_RS13860	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TPH_RS13870	COG0523	cobalamin synthesis protein
TPH_RS13880	COG5012	cobalamin binding
TPH_RS13885	COG2188	Transcriptional regulator
TPH_RS13890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TPH_RS13895	COG5012	cobalamin binding
TPH_RS13900	COG1361	Conserved repeat domain
TPH_RS13905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TPH_RS13920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TPH_RS13935	COG0739	heme binding
TPH_RS13960	COG1361	Conserved repeat domain
TPH_RS13980	COG2385	sporulation resulting in formation of a cellular spore
TPH_RS13985	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TPH_RS13995	COG3956	TIGRFAM MazG family protein
TPH_RS14000	COG2244	polysaccharide biosynthetic process
TPH_RS14005	COG2002	toxin-antitoxin pair type II binding
TPH_RS14010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TPH_RS14015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TPH_RS14025	COG0193	aminoacyl-tRNA hydrolase activity
TPH_RS14030	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TPH_RS14040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TPH_RS14045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TPH_RS14050	COG2088	sporulation resulting in formation of a cellular spore
TPH_RS14060	COG1802	Transcriptional regulator
TPH_RS14065	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TPH_RS14070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TPH_RS14070	COG0189	ligase activity
TPH_RS14075	COG4242	Belongs to the peptidase S51 family
TPH_RS14080	COG0428	transporter
TPH_RS14090	COG1376	ErfK ybiS ycfS ynhG family protein
TPH_RS14095	COG2340	Cysteine-rich secretory protein family
TPH_RS14110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TPH_RS14125	COG1752	Esterase of the alpha-beta hydrolase superfamily
TPH_RS14160	COG2340	Cysteine-rich secretory protein family
TPH_RS14170	COG4466	Protein conserved in bacteria
TPH_RS14195	COG1533	DNA photolyase activity
TPH_RS14210	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TPH_RS14215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TPH_RS14220	COG3584	3D domain protein
TPH_RS14220	COG3583	domain protein
TPH_RS14225	COG1388	LysM domain
TPH_RS14225	COG3584	3D domain protein
TPH_RS14230	COG0084	hydrolase, TatD family'
TPH_RS14240	COG3464	Transposase
TPH_RS14245	COG2002	toxin-antitoxin pair type II binding
TPH_RS14250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TPH_RS14255	COG1774	PSP1 C-terminal conserved region
TPH_RS14260	COG0470	DNA polymerase III
TPH_RS14265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TPH_RS14270	COG1982	Orn Lys Arg decarboxylase major
TPH_RS14320	COG0489	protein tyrosine kinase activity
TPH_RS14330	COG0569	domain protein
TPH_RS14345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TPH_RS14360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TPH_RS14365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TPH_RS14370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TPH_RS14385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TPH_RS14390	COG0668	transmembrane transport
TPH_RS14400	COG0590	tRNA wobble adenosine to inosine editing
TPH_RS14435	COG0390	transport system, permease component
TPH_RS14440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity