locus-tag	class	description
AB849_RS00010	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AB849_RS00015	COG0740	serine-type endopeptidase activity
AB849_RS00020	COG0544	peptidyl-prolyl cis-trans isomerase activity
AB849_RS00050	COG0183	Belongs to the thiolase family
AB849_RS00055	COG0318	PFAM AMP-dependent synthetase and ligase
AB849_RS00070	COG1959	2 iron, 2 sulfur cluster binding
AB849_RS00075	COG5583	Uncharacterized small protein (DUF2292)
AB849_RS00080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AB849_RS00090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AB849_RS00095	COG1116	anion transmembrane transporter activity
AB849_RS00100	COG0534	Mate efflux family protein
AB849_RS00110	COG5002	protein histidine kinase activity
AB849_RS00115	COG0745	RESPONSE REGULATOR receiver
AB849_RS00135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AB849_RS00140	COG2226	methyltransferase
AB849_RS00145	COG2135	peptidase activity
AB849_RS00215	COG0622	Phosphoesterase
AB849_RS00220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AB849_RS00225	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AB849_RS00235	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AB849_RS00240	COG1846	Transcriptional regulator
AB849_RS00255	COG1846	Transcriptional regulator
AB849_RS00260	COG1304	FMN binding
AB849_RS00265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AB849_RS00270	COG1032	radical SAM domain protein
AB849_RS00280	COG0456	acetyltransferase
AB849_RS00305	COG2032	superoxide dismutase activity
AB849_RS00310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AB849_RS00315	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AB849_RS00330	COG0010	Belongs to the arginase family
AB849_RS00335	COG3829	transcription factor binding
AB849_RS00340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AB849_RS00345	COG3290	protein histidine kinase activity
AB849_RS00345	COG3829	transcription factor binding
AB849_RS00350	COG1960	acyl-CoA dehydrogenase activity
AB849_RS00355	COG1960	acyl-CoA dehydrogenase activity
AB849_RS00360	COG0318	PFAM AMP-dependent synthetase and ligase
AB849_RS00380	COG2030	dehydratase
AB849_RS00385	COG1960	acyl-CoA dehydrogenase activity
AB849_RS00390	COG1028	Short-chain dehydrogenase reductase Sdr
AB849_RS00425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AB849_RS00435	COG2226	methyltransferase
AB849_RS00445	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AB849_RS00485	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AB849_RS00495	COG1414	Transcriptional regulator
AB849_RS00500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AB849_RS00505	COG0800	Aldolase
AB849_RS00510	COG4948	Mandelate Racemase Muconate Lactonizing
AB849_RS00515	COG2271	Major facilitator Superfamily
AB849_RS00520	COG3848	Pyruvate phosphate dikinase
AB849_RS00520	COG0574	Belongs to the PEP-utilizing enzyme family
AB849_RS00590	COG1492	cobalamin metabolic process
AB849_RS00605	COG2160	L-arabinose isomerase activity
AB849_RS00610	COG0235	Class ii aldolase
AB849_RS00615	COG1609	Transcriptional regulator
AB849_RS00625	COG1797	cobyrinic acid a,c-diamide synthase activity
AB849_RS00630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AB849_RS00645	COG1515	deoxyribonuclease V activity
AB849_RS00650	COG3829	transcription factor binding
AB849_RS00650	COG3290	protein histidine kinase activity
AB849_RS00660	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AB849_RS00670	COG2197	response regulator
AB849_RS00675	COG0006	proline dipeptidase activity
AB849_RS00690	COG1733	regulation of RNA biosynthetic process
AB849_RS00705	COG4086	secreted protein
AB849_RS00710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AB849_RS00715	COG1053	succinate dehydrogenase
AB849_RS00720	COG2009	succinate dehydrogenase
AB849_RS00725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AB849_RS00730	COG0444	Belongs to the ABC transporter superfamily
AB849_RS00735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AB849_RS00740	COG0601	transmembrane transport
AB849_RS00755	COG1233	COG1233 Phytoene dehydrogenase and related
AB849_RS00770	COG0322	excinuclease ABC activity
AB849_RS00780	COG3118	belongs to the thioredoxin family
AB849_RS00785	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AB849_RS00790	COG2086	electron transfer activity
AB849_RS00795	COG1309	transcriptional regulator
AB849_RS00800	COG0318	PFAM AMP-dependent synthetase and ligase
AB849_RS00805	COG0697	spore germination
AB849_RS00820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AB849_RS00820	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AB849_RS00830	COG4129	membrane
AB849_RS00845	COG1193	negative regulation of DNA recombination
AB849_RS00855	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AB849_RS00855	COG1796	DNA polymerase
AB849_RS00865	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AB849_RS00870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AB849_RS00870	COG0072	phenylalanine-tRNA ligase activity
AB849_RS00875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AB849_RS00880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AB849_RS00885	COG0569	domain protein
AB849_RS00900	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AB849_RS00910	COG0351	phosphomethylpyrimidine kinase
AB849_RS00915	COG0352	thiamine-phosphate diphosphorylase activity
AB849_RS00930	COG1649	PFAM Uncharacterised BCR, COG1649
AB849_RS00935	COG0473	3-isopropylmalate dehydrogenase activity
AB849_RS00940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AB849_RS00945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AB849_RS00950	COG0440	acetolactate synthase activity
AB849_RS00955	COG0028	Belongs to the TPP enzyme family
AB849_RS00970	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AB849_RS00975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AB849_RS00980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AB849_RS00985	COG2322	membrane
AB849_RS00990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AB849_RS01005	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AB849_RS01025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AB849_RS01030	COG0386	Belongs to the glutathione peroxidase family
AB849_RS01035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AB849_RS01045	COG0237	dephospho-CoA kinase activity
AB849_RS01050	COG1971	Probably functions as a manganese efflux pump
AB849_RS01055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AB849_RS01060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AB849_RS01060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AB849_RS01065	COG1609	Transcriptional regulator
AB849_RS01070	COG0673	inositol 2-dehydrogenase activity
AB849_RS01080	COG3962	Belongs to the TPP enzyme family
AB849_RS01085	COG1012	belongs to the aldehyde dehydrogenase family
AB849_RS01095	COG3718	enzyme involved in inositol metabolism
AB849_RS01100	COG0673	inositol 2-dehydrogenase activity
AB849_RS01105	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AB849_RS01145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AB849_RS01150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AB849_RS01155	COG0581	inorganic phosphate transmembrane transporter activity
AB849_RS01160	COG0573	inorganic phosphate transmembrane transporter activity
AB849_RS01165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AB849_RS01170	COG5002	protein histidine kinase activity
AB849_RS01175	COG0745	RESPONSE REGULATOR receiver
AB849_RS01190	COG0538	isocitrate dehydrogenase activity
AB849_RS01195	COG0372	Belongs to the citrate synthase family
AB849_RS01200	COG0628	permease
AB849_RS01210	COG0824	Thioesterase
AB849_RS01220	COG0205	6-phosphofructokinase activity
AB849_RS01225	COG0825	malonyl-CoA metabolic process
AB849_RS01230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AB849_RS01235	COG2186	Transcriptional regulator
AB849_RS01240	COG0281	malic enzyme
AB849_RS01255	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AB849_RS01260	COG0587	DNA-directed DNA polymerase activity
AB849_RS01280	COG4109	DRTGG domain
AB849_RS01295	COG0189	ligase activity
AB849_RS01300	COG0189	ligase activity
AB849_RS01305	COG0189	ligase activity
AB849_RS01310	COG0189	ligase activity
AB849_RS01320	COG0791	NLP P60 protein
AB849_RS01330	COG2719	SpoVR family
AB849_RS01335	COG2239	Acts as a magnesium transporter
AB849_RS01345	COG0697	spore germination
AB849_RS01350	COG0531	amino acid
AB849_RS01365	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AB849_RS01370	COG3844	kynureninase activity
AB849_RS01390	COG0028	Belongs to the TPP enzyme family
AB849_RS01395	COG0655	NAD(P)H dehydrogenase (quinone) activity
AB849_RS01405	COG0318	PFAM AMP-dependent synthetase and ligase
AB849_RS01410	COG0318	PFAM AMP-dependent synthetase and ligase
AB849_RS01440	COG0076	glutamate decarboxylase activity
AB849_RS01455	COG0686	Belongs to the AlaDH PNT family
AB849_RS01460	COG2508	Transcriptional regulator
AB849_RS01465	COG0470	DNA polymerase III
AB849_RS01475	COG1307	EDD domain protein, DegV family
AB849_RS01480	COG1657	PFAM Prenyltransferase squalene oxidase
AB849_RS01485	COG1484	DNA-dependent DNA replication
AB849_RS01515	COG2130	NADP-dependent
AB849_RS01520	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AB849_RS01525	COG1131	(ABC) transporter
AB849_RS01530	COG0460	homoserine dehydrogenase
AB849_RS01540	COG1253	flavin adenine dinucleotide binding
AB849_RS01545	COG0501	Belongs to the peptidase M48B family
AB849_RS01575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AB849_RS01585	COG1968	undecaprenyl-diphosphatase activity
AB849_RS01590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AB849_RS01610	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AB849_RS01620	COG1876	peptidase activity
AB849_RS01635	COG0753	catalase activity
AB849_RS01640	COG0586	Pfam SNARE associated Golgi protein
AB849_RS01645	COG4974	Belongs to the 'phage' integrase family
AB849_RS01650	COG2364	Membrane
AB849_RS01655	COG3209	COG3209 Rhs family protein
AB849_RS01660	COG1486	melibiose metabolic process
AB849_RS01745	COG0551	DNA topoisomerase type I activity
AB849_RS01745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AB849_RS01750	COG1231	oxidoreductase activity
AB849_RS01765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AB849_RS01790	COG1279	arginine transmembrane transporter activity
AB849_RS01800	COG2718	Belongs to the UPF0229 family
AB849_RS01805	COG2766	serine protein kinase
AB849_RS01815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AB849_RS01830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AB849_RS01840	COG0328	RNA-DNA hybrid ribonuclease activity
AB849_RS01850	COG1573	uracil-dna glycosylase
AB849_RS01855	COG0561	phosphatase activity
AB849_RS01905	COG1309	transcriptional regulator
AB849_RS01915	COG0095	Lipoate-protein ligase
AB849_RS01920	COG0514	ATP-dependent DNA helicase (RecQ)
AB849_RS01930	COG1234	tRNA 3'-trailer cleavage
AB849_RS01940	COG0477	Major facilitator Superfamily
AB849_RS01945	COG0668	transmembrane transport
AB849_RS01955	COG3591	Belongs to the peptidase S1B family
AB849_RS01965	COG1331	Highly conserved protein containing a thioredoxin domain
AB849_RS01975	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AB849_RS02010	COG3711	transcriptional antiterminator
AB849_RS02030	COG0398	Pfam SNARE associated Golgi protein
AB849_RS02040	COG2176	DNA-directed DNA polymerase activity
AB849_RS02045	COG1012	belongs to the aldehyde dehydrogenase family
AB849_RS02055	COG2340	Cysteine-rich secretory protein family
AB849_RS02085	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AB849_RS02090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AB849_RS02095	COG1597	lipid kinase activity
AB849_RS02105	COG1252	NADH dehydrogenase
AB849_RS02110	COG0492	ferredoxin-NADP+ reductase activity
AB849_RS02120	COG0316	Belongs to the HesB IscA family
AB849_RS02130	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AB849_RS02135	COG4844	belongs to the
AB849_RS02155	COG2843	Capsule synthesis protein
AB849_RS02165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AB849_RS02170	COG4837	Protein of unknown function (DUF1462)
AB849_RS02175	COG0626	cystathionine gamma-synthase activity
AB849_RS02180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AB849_RS02185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AB849_RS02195	COG4608	Belongs to the ABC transporter superfamily
AB849_RS02200	COG0444	Belongs to the ABC transporter superfamily
AB849_RS02205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AB849_RS02210	COG0601	transmembrane transport
AB849_RS02215	COG4166	transmembrane transport
AB849_RS02220	COG4166	transmembrane transport
AB849_RS02235	COG1297	OPT oligopeptide transporter protein
AB849_RS02240	COG0277	FAD linked oxidase domain protein
AB849_RS02245	COG0247	lactate metabolic process
AB849_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
AB849_RS02265	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AB849_RS02275	COG0647	UMP catabolic process
AB849_RS02280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AB849_RS02290	COG2445	Protein of unknown function DUF86
AB849_RS02300	COG5577	PFAM Coat F domain
AB849_RS02320	COG4470	Protein conserved in bacteria
AB849_RS02330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AB849_RS02335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AB849_RS02340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AB849_RS02345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AB849_RS02350	COG0739	heme binding
AB849_RS02355	COG0531	amino acid
AB849_RS02360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AB849_RS02365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AB849_RS02370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AB849_RS02375	COG0601	transmembrane transport
AB849_RS02380	COG0747	negative chemotaxis
AB849_RS02385	COG4608	Belongs to the ABC transporter superfamily
AB849_RS02390	COG0444	Belongs to the ABC transporter superfamily
AB849_RS02395	COG0351	phosphomethylpyrimidine kinase
AB849_RS02415	COG1115	amino acid carrier protein
AB849_RS02420	COG1755	Isoprenylcysteine carboxyl methyltransferase
AB849_RS02425	COG3424	synthase
AB849_RS02440	COG0739	heme binding
AB849_RS02455	COG0433	COG0433 Predicted ATPase
AB849_RS02475	COG3764	Sortase (surface protein transpeptidase)
AB849_RS02500	COG0778	Nitroreductase
AB849_RS02505	COG0535	radical SAM domain protein
AB849_RS02515	COG1278	Cold shock
AB849_RS02520	COG3377	Domain of unknown function (DUF1805)
AB849_RS02530	COG0737	Belongs to the 5'-nucleotidase family
AB849_RS02535	COG1801	Protein of unknown function DUF72
AB849_RS02545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AB849_RS02550	COG2224	Isocitrate lyase
AB849_RS02555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AB849_RS02560	COG0628	permease
AB849_RS02565	COG1295	ribonuclease BN
AB849_RS02580	COG2171	N-acyltransferase activity
AB849_RS02585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AB849_RS02590	COG1473	amidohydrolase
AB849_RS02620	COG0582	viral genome integration into host DNA
AB849_RS02630	COG0719	Fe-S assembly protein
AB849_RS02635	COG0822	iron-sulfur transferase activity
AB849_RS02640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AB849_RS02645	COG0719	Fe-S assembly protein
AB849_RS02650	COG0396	ATPase activity
AB849_RS02665	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AB849_RS02690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AB849_RS02695	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AB849_RS02700	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AB849_RS02705	COG0235	Class ii aldolase
AB849_RS02710	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AB849_RS02715	COG1850	ribulose-bisphosphate carboxylase activity
AB849_RS02720	COG0702	epimerase
AB849_RS02735	COG0477	Major facilitator Superfamily
AB849_RS02755	COG0735	belongs to the Fur family
AB849_RS02765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AB849_RS02775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AB849_RS02800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AB849_RS02805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AB849_RS02805	COG1263	PTS System
AB849_RS02810	COG1486	melibiose metabolic process
AB849_RS02815	COG1737	Transcriptional regulator
AB849_RS02820	COG4326	sporulation control protein
AB849_RS02840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AB849_RS02845	COG2346	COG2346, Truncated hemoglobins
AB849_RS02855	COG0596	Alpha beta hydrolase
AB849_RS02875	COG1845	cytochrome c oxidase, subunit III
AB849_RS02885	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AB849_RS02885	COG2010	Cytochrome c
AB849_RS02890	COG0109	protoheme IX farnesyltransferase activity
AB849_RS02900	COG1132	(ABC) transporter
AB849_RS02905	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AB849_RS02920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AB849_RS02935	COG2720	vancomycin resistance protein
AB849_RS02945	COG1988	membrane-bound metal-dependent
AB849_RS02950	COG0668	transmembrane transport
AB849_RS02955	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AB849_RS02960	COG1388	LysM domain
AB849_RS02960	COG3584	3D domain protein
AB849_RS02975	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AB849_RS02990	COG0151	Belongs to the GarS family
AB849_RS03000	COG0138	bifunctional purine biosynthesis protein purh
AB849_RS03005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AB849_RS03010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AB849_RS03015	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AB849_RS03020	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AB849_RS03025	COG0047	phosphoribosylformylglycinamidine synthase activity
AB849_RS03030	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AB849_RS03035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AB849_RS03040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AB849_RS03045	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AB849_RS03050	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AB849_RS03080	COG2252	PERMEase
AB849_RS03085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AB849_RS03085	COG0519	Catalyzes the synthesis of GMP from XMP
AB849_RS03090	COG1902	pentaerythritol trinitrate reductase activity
AB849_RS03110	COG1929	Belongs to the glycerate kinase type-1 family
AB849_RS03115	COG2610	gluconate transmembrane transporter activity
AB849_RS03130	COG1028	Short-chain dehydrogenase reductase Sdr
AB849_RS03215	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AB849_RS03220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AB849_RS03230	COG0028	Belongs to the TPP enzyme family
AB849_RS03235	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AB849_RS03245	COG0739	heme binding
AB849_RS03255	COG2814	Major facilitator Superfamily
AB849_RS03255	COG0477	Major facilitator Superfamily
AB849_RS03260	COG2115	Belongs to the xylose isomerase family
AB849_RS03265	COG0459	protein refolding
AB849_RS03270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AB849_RS03280	COG0805	protein transport
AB849_RS03285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AB849_RS03290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AB849_RS03295	COG0488	(ABC) transporter
AB849_RS03300	COG1984	allophanate hydrolase subunit 2
AB849_RS03305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AB849_RS03310	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AB849_RS03320	COG0456	acetyltransferase
AB849_RS03325	COG1214	PFAM Peptidase M22, glycoprotease
AB849_RS03330	COG0802	atpase or kinase
AB849_RS03335	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AB849_RS03410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AB849_RS03415	COG2084	Dehydrogenase
AB849_RS03425	COG2183	response to ionizing radiation
AB849_RS03435	COG3850	Histidine kinase
AB849_RS03435	COG5002	protein histidine kinase activity
AB849_RS03445	COG3963	phosphatidate phosphatase activity
AB849_RS03450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AB849_RS03455	COG1191	sigma factor activity
AB849_RS03460	COG2172	sigma factor antagonist activity
AB849_RS03470	COG2208	phosphoserine phosphatase activity
AB849_RS03475	COG2337	Toxic component of a toxin-antitoxin (TA) module
AB849_RS03480	COG0864	Transcriptional regulator
AB849_RS03485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AB849_RS03495	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AB849_RS03500	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AB849_RS03500	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AB849_RS03530	COG0833	amino acid
AB849_RS03550	COG5002	protein histidine kinase activity
AB849_RS03555	COG0745	RESPONSE REGULATOR receiver
AB849_RS03565	COG0488	(ABC) transporter
AB849_RS03570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AB849_RS03575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AB849_RS03585	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AB849_RS03725	COG0726	polysaccharide deacetylase
AB849_RS03740	COG0489	protein tyrosine kinase activity
AB849_RS03745	COG0860	N-Acetylmuramoyl-L-alanine amidase
AB849_RS03765	COG0753	catalase activity
AB849_RS03780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AB849_RS03785	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AB849_RS03790	COG0101	tRNA pseudouridine synthase activity
AB849_RS03795	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AB849_RS03800	COG1122	ATPase activity
AB849_RS03810	COG0203	ribosomal protein L17
AB849_RS03815	COG0202	RNA polymerase activity
AB849_RS03820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AB849_RS03825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AB849_RS03830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AB849_RS03835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AB849_RS03845	COG0024	Methionine aminopeptidase
AB849_RS03850	COG0563	adenylate kinase activity
AB849_RS03855	COG0201	protein transport
AB849_RS03870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AB849_RS03875	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AB849_RS03880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AB849_RS03885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AB849_RS03895	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AB849_RS03905	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AB849_RS03910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AB849_RS03915	COG0255	Belongs to the universal ribosomal protein uL29 family
AB849_RS03920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AB849_RS03925	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AB849_RS03930	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AB849_RS03935	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AB849_RS03940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AB849_RS03945	COG0089	rRNA binding
AB849_RS03955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AB849_RS03965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AB849_RS03970	COG0710	3-dehydroquinate dehydratase activity
AB849_RS03975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AB849_RS03980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AB849_RS03985	COG0049	tRNA binding
AB849_RS03990	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AB849_RS03995	COG1358	cellular component organization or biogenesis
AB849_RS04000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AB849_RS04005	COG0085	RNA polymerase activity
AB849_RS04010	COG2813	Specifically methylates the guanine in position
AB849_RS04015	COG0222	ribosome binding
AB849_RS04020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AB849_RS04025	COG0081	regulation of translation
AB849_RS04030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AB849_RS04035	COG0250	Participates in transcription elongation, termination and antitermination
AB849_RS04045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AB849_RS04060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AB849_RS04065	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AB849_RS04070	COG0215	cysteine-tRNA ligase activity
AB849_RS04075	COG1045	serine acetyltransferase
AB849_RS04080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AB849_RS04085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AB849_RS04090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AB849_RS04095	COG4956	integral membrane protein (PIN domain superfamily)
AB849_RS04100	COG1329	Transcriptional regulator
AB849_RS04110	COG1183	phosphatidylcholine synthase activity
AB849_RS04115	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AB849_RS04120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AB849_RS04125	COG0542	response to heat
AB849_RS04130	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AB849_RS04135	COG3880	PFAM UvrB UvrC protein
AB849_RS04145	COG1285	pathogenesis
AB849_RS04155	COG4585	Histidine kinase
AB849_RS04200	COG0443	Heat shock 70 kDa protein
AB849_RS04215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AB849_RS04220	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AB849_RS04225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AB849_RS04230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AB849_RS04235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AB849_RS04245	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AB849_RS04250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AB849_RS04255	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AB849_RS04260	COG0037	tRNA processing
AB849_RS04265	COG2208	phosphoserine phosphatase activity
AB849_RS04285	COG3876	Protein conserved in bacteria
AB849_RS04305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AB849_RS04310	COG3956	TIGRFAM MazG family protein
AB849_RS04315	COG2244	polysaccharide biosynthetic process
AB849_RS04320	COG2002	toxin-antitoxin pair type II binding
AB849_RS04330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AB849_RS04340	COG0193	aminoacyl-tRNA hydrolase activity
AB849_RS04345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AB849_RS04350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AB849_RS04355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AB849_RS04360	COG2088	sporulation resulting in formation of a cellular spore
AB849_RS04365	COG0251	oxidation-reduction process
AB849_RS04370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AB849_RS04375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AB849_RS04385	COG4466	Protein conserved in bacteria
AB849_RS04395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AB849_RS04405	COG0084	hydrolase, TatD family'
AB849_RS04415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AB849_RS04415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AB849_RS04430	COG2002	toxin-antitoxin pair type II binding
AB849_RS04435	COG1263	PTS System
AB849_RS04435	COG2190	(PTS) system
AB849_RS04435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AB849_RS04440	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AB849_RS04445	COG2827	Endonuclease containing a URI domain
AB849_RS04450	COG4467	Involved in initiation control of chromosome replication
AB849_RS04455	COG1774	PSP1 C-terminal conserved region
AB849_RS04460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AB849_RS04465	COG1982	Orn Lys Arg decarboxylase major
AB849_RS04505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AB849_RS04510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AB849_RS04515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AB849_RS04520	COG5002	protein histidine kinase activity
AB849_RS04530	COG1263	PTS System
AB849_RS04530	COG2190	(PTS) system
AB849_RS04530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AB849_RS04535	COG0366	Alpha amylase catalytic
AB849_RS04540	COG2188	Transcriptional regulator
AB849_RS04545	COG0095	Lipoate-protein ligase
AB849_RS04555	COG0655	NAD(P)H dehydrogenase (quinone) activity
AB849_RS04560	COG2814	Major facilitator Superfamily
AB849_RS04565	COG1566	PFAM secretion protein HlyD family protein
AB849_RS04570	COG1566	PFAM secretion protein HlyD family protein
AB849_RS04575	COG1846	Transcriptional regulator
AB849_RS04580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AB849_RS04590	COG0584	glycerophosphoryl diester phosphodiesterase
AB849_RS04610	COG2211	Major facilitator Superfamily
AB849_RS04615	COG1472	Belongs to the glycosyl hydrolase 3 family
AB849_RS04620	COG1070	Carbohydrate kinase
AB849_RS04655	COG1070	Carbohydrate kinase
AB849_RS04660	COG2610	gluconate transmembrane transporter activity
AB849_RS04665	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AB849_RS04700	COG0590	tRNA wobble adenosine to inosine editing
AB849_RS04705	COG0735	belongs to the Fur family
AB849_RS04710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AB849_RS04715	COG1121	(ABC) transporter
AB849_RS04725	COG4195	phage-related replication protein
AB849_RS04730	COG1511	domain protein
AB849_RS04745	COG0783	Belongs to the Dps family
AB849_RS04755	COG2814	Major facilitator Superfamily
AB849_RS04760	COG0531	amino acid
AB849_RS04765	COG0367	asparagine synthase
AB849_RS04775	COG1253	flavin adenine dinucleotide binding
AB849_RS04780	COG0745	RESPONSE REGULATOR receiver
AB849_RS04785	COG5002	protein histidine kinase activity
AB849_RS04800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AB849_RS04810	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AB849_RS04815	COG1686	Belongs to the peptidase S11 family
AB849_RS04820	COG0516	GMP reductase activity
AB849_RS04820	COG0517	IMP dehydrogenase activity
AB849_RS04835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AB849_RS04840	COG0187	DNA topoisomerase II activity
AB849_RS04850	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AB849_RS04860	COG0592	DNA-directed DNA polymerase activity
AB849_RS04870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AB849_RS04890	COG1847	R3H domain protein
AB849_RS04895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AB849_RS04900	COG0445	tRNA wobble uridine modification
AB849_RS04905	COG0357	Ribosomal RNA small subunit methyltransferase G
AB849_RS04920	COG1475	DNA binding
AB849_RS04925	COG1192	Involved in chromosome partitioning
AB849_RS04930	COG1475	DNA binding
AB849_RS04935	COG1104	cysteine desulfurase activity
AB849_RS04945	COG4481	Protein conserved in bacteria
AB849_RS04950	COG0012	GTP binding
AB849_RS04955	COG0360	Binds together with S18 to 16S ribosomal RNA
AB849_RS04960	COG0629	single-stranded DNA binding
AB849_RS04965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AB849_RS04980	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AB849_RS04985	COG0359	binds to the 23S rRNA
AB849_RS04990	COG0305	Participates in initiation and elongation during chromosome replication
AB849_RS04995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AB849_RS05005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AB849_RS05015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AB849_RS05030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AB849_RS05045	COG5002	protein histidine kinase activity
AB849_RS05050	COG0745	RESPONSE REGULATOR receiver
AB849_RS05055	COG0189	ligase activity
AB849_RS05065	COG3852	Histidine kinase
AB849_RS05080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AB849_RS05085	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AB849_RS05090	COG0010	Belongs to the arginase family
AB849_RS05100	COG0018	arginyl-trna synthetase
AB849_RS05105	COG0515	serine threonine protein kinase
AB849_RS05105	COG2815	serine threonine protein kinase
AB849_RS05115	COG0604	alcohol dehydrogenase
AB849_RS05120	COG1509	lysine 2,3-aminomutase activity
AB849_RS05130	COG1193	negative regulation of DNA recombination
AB849_RS05135	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AB849_RS05140	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AB849_RS05160	COG2181	nitrate reductase activity
AB849_RS05160	COG0247	lactate metabolic process
AB849_RS05165	COG0745	RESPONSE REGULATOR receiver
AB849_RS05170	COG5002	protein histidine kinase activity
AB849_RS05175	COG0183	Belongs to the thiolase family
AB849_RS05180	COG1250	3-hydroxyacyl-CoA dehydrogenase
AB849_RS05185	COG1960	acyl-CoA dehydrogenase activity
AB849_RS05190	COG1960	acyl-CoA dehydrogenase activity
AB849_RS05200	COG1309	transcriptional regulator
AB849_RS05205	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AB849_RS05205	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AB849_RS05205	COG1703	isobutyryl-CoA mutase activity
AB849_RS05210	COG3343	RNA polymerase activity
AB849_RS05215	COG0504	CTP synthase activity
AB849_RS05220	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AB849_RS05230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AB849_RS05240	COG2204	response regulator
AB849_RS05245	COG1607	acyl-coa hydrolase
AB849_RS05250	COG3246	L-lysine catabolic process to acetate
AB849_RS05255	COG0191	fructose-bisphosphate aldolase activity
AB849_RS05260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AB849_RS05265	COG1494	fructose-1,6-bisphosphatase
AB849_RS05270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AB849_RS05275	COG0739	heme binding
AB849_RS05280	COG0254	rRNA binding
AB849_RS05285	COG1435	thymidine kinase activity
AB849_RS05295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AB849_RS05315	COG0009	L-threonylcarbamoyladenylate synthase
AB849_RS05320	COG1408	metallophosphoesterase
AB849_RS05325	COG1971	Probably functions as a manganese efflux pump
AB849_RS05330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AB849_RS05335	COG0698	ribose 5-phosphate isomerase
AB849_RS05340	COG4475	Protein of unknown function (DUF436)
AB849_RS05345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AB849_RS05350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AB849_RS05380	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AB849_RS05385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AB849_RS05390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AB849_RS05395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AB849_RS05400	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AB849_RS05405	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AB849_RS05410	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AB849_RS05415	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AB849_RS05420	COG0649	NAD binding
AB849_RS05425	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AB849_RS05430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AB849_RS05435	COG0839	Belongs to the complex I subunit 6 family
AB849_RS05445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AB849_RS05455	COG1007	ATP synthesis coupled electron transport
AB849_RS05470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AB849_RS05475	COG2385	sporulation resulting in formation of a cellular spore
AB849_RS05485	COG0739	heme binding
AB849_RS05490	COG1609	Transcriptional regulator
AB849_RS05500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AB849_RS05505	COG0281	malic enzyme
AB849_RS05510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AB849_RS05515	COG0297	glycogen (starch) synthase activity
AB849_RS05515	COG0438	transferase activity, transferring glycosyl groups
AB849_RS05555	COG1316	TRANSCRIPTIONal
AB849_RS05560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AB849_RS05565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AB849_RS05570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AB849_RS05575	COG2011	ABC-type metal ion transport system permease component
AB849_RS05580	COG1464	Belongs to the NlpA lipoprotein family
AB849_RS05585	COG1739	Uncharacterized protein family UPF0029
AB849_RS05590	COG1316	TRANSCRIPTIONal
AB849_RS05600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AB849_RS05605	COG2197	response regulator
AB849_RS05615	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AB849_RS05620	COG1040	competence protein
AB849_RS05635	COG0765	amino acid transport
AB849_RS05645	COG1278	Cold shock
AB849_RS05650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AB849_RS05665	COG0653	protein targeting
AB849_RS05675	COG1024	Enoyl-CoA hydratase
AB849_RS05690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AB849_RS05695	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AB849_RS05700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AB849_RS05710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AB849_RS05730	COG0861	Integral membrane protein TerC family
AB849_RS05750	COG0137	argininosuccinate synthase activity
AB849_RS05755	COG0165	Argininosuccinate lyase
AB849_RS05760	COG2884	Cell division ATP-binding protein ftsE
AB849_RS05765	COG2177	Part of the ABC transporter FtsEX involved in
AB849_RS05770	COG4942	peptidase
AB849_RS05775	COG4942	peptidase
AB849_RS05785	COG0793	Belongs to the peptidase S41A family
AB849_RS05785	COG3409	Peptidoglycan-binding domain 1 protein
AB849_RS05790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AB849_RS05795	COG0556	nucleotide-excision repair
AB849_RS05800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AB849_RS05820	COG1950	PFAM Membrane protein of
AB849_RS05825	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AB849_RS05830	COG3764	Sortase (surface protein transpeptidase)
AB849_RS05835	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AB849_RS05840	COG2233	PERMEase
AB849_RS05855	COG0546	phosphoglycolate phosphatase activity
AB849_RS05860	COG0110	maltose O-acetyltransferase activity
AB849_RS05865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AB849_RS05885	COG0167	dihydroorotate dehydrogenase activity
AB849_RS05895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AB849_RS05900	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AB849_RS05905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AB849_RS05910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AB849_RS05915	COG0131	Imidazoleglycerol-phosphate dehydratase
AB849_RS05920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AB849_RS05925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AB849_RS05930	COG0107	imidazoleglycerol-phosphate synthase activity
AB849_RS05935	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AB849_RS05935	COG0140	phosphoribosyl-ATP diphosphatase activity
AB849_RS05940	COG0457	Tetratricopeptide repeat
AB849_RS05945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AB849_RS05950	COG1940	carbohydrate kinase activity
AB849_RS05960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AB849_RS05965	COG1481	regulation of sporulation
AB849_RS05970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AB849_RS05985	COG0740	serine-type endopeptidase activity
AB849_RS06000	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AB849_RS06015	COG0126	phosphoglycerate kinase activity
AB849_RS06020	COG0149	triose-phosphate isomerase activity
AB849_RS06030	COG0148	phosphopyruvate hydratase activity
AB849_RS06035	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AB849_RS06050	COG1647	Serine aminopeptidase, S33
AB849_RS06055	COG0557	exoribonuclease II activity
AB849_RS06060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AB849_RS06075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AB849_RS06075	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AB849_RS06095	COG0163	prenyltransferase activity
AB849_RS06100	COG1272	protein, Hemolysin III
AB849_RS06105	COG0318	PFAM AMP-dependent synthetase and ligase
AB849_RS06115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AB849_RS06125	COG0039	L-malate dehydrogenase activity
AB849_RS06130	COG1620	l-lactate permease
AB849_RS06135	COG3189	MarR family transcriptional regulator
AB849_RS06140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AB849_RS06140	COG3711	transcriptional antiterminator
AB849_RS06160	COG1674	ftsk spoiiie
AB849_RS06175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AB849_RS06200	COG2091	lysine biosynthetic process via aminoadipic acid
AB849_RS06210	COG0475	glutathione-regulated potassium exporter activity
AB849_RS06215	COG3162	membrane
AB849_RS06220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AB849_RS06265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AB849_RS06270	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AB849_RS06280	COG1556	Lactate utilization protein
AB849_RS06290	COG0247	lactate metabolic process
AB849_RS06295	COG2186	Transcriptional regulator
AB849_RS06305	COG0667	Aldo Keto reductase
AB849_RS06320	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AB849_RS06325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AB849_RS06325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AB849_RS06325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AB849_RS06330	COG1105	Belongs to the carbohydrate kinase PfkB family
AB849_RS06335	COG1349	DNA-binding transcription factor activity
AB849_RS06345	COG1410	methionine synthase
AB849_RS06345	COG0646	methionine synthase
AB849_RS06350	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AB849_RS06350	COG0646	methionine synthase
AB849_RS06360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AB849_RS06390	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AB849_RS06400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AB849_RS06405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AB849_RS06410	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AB849_RS06410	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AB849_RS06415	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AB849_RS06420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AB849_RS06425	COG4326	sporulation control protein
AB849_RS06440	COG1250	3-hydroxyacyl-CoA dehydrogenase
AB849_RS06440	COG1024	Enoyl-CoA hydratase
AB849_RS06445	COG0183	Belongs to the thiolase family
AB849_RS06450	COG1960	acyl-CoA dehydrogenase activity
AB849_RS06470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AB849_RS06480	COG1966	Carbon starvation protein
AB849_RS06490	COG0154	amidase activity
AB849_RS06495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AB849_RS06520	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AB849_RS06525	COG2252	PERMEase
AB849_RS06530	COG1597	lipid kinase activity
AB849_RS06535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AB849_RS06555	COG0477	Major facilitator Superfamily
AB849_RS06560	COG2267	carboxylic ester hydrolase activity
AB849_RS06570	COG0450	alkyl hydroperoxide reductase
AB849_RS06575	COG0789	Transcriptional regulator
AB849_RS06585	COG2226	methyltransferase
AB849_RS06625	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AB849_RS06665	COG4750	Nucleotidyl transferase
AB849_RS06670	COG0697	spore germination
AB849_RS06680	COG3475	LICD family
AB849_RS06690	COG1785	Belongs to the alkaline phosphatase family
AB849_RS06695	COG1307	EDD domain protein, DegV family
AB849_RS06705	COG1120	ATPase activity
AB849_RS06710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AB849_RS06715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AB849_RS06720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AB849_RS06730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AB849_RS06735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AB849_RS06750	COG0778	Nitroreductase
AB849_RS06755	COG0860	N-Acetylmuramoyl-L-alanine amidase
AB849_RS06760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AB849_RS06770	COG1380	Effector of murein hydrolase LrgA
AB849_RS06775	COG1346	cytolysis
AB849_RS06780	COG2814	Major facilitator Superfamily
AB849_RS06785	COG0583	DNA-binding transcription factor activity
AB849_RS06790	COG1470	cell adhesion involved in biofilm formation
AB849_RS06795	COG4496	protein, YerC YecD
AB849_RS06800	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AB849_RS06805	COG0210	DNA helicase
AB849_RS06810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AB849_RS06815	COG1305	Transglutaminase-like
AB849_RS06820	COG1116	anion transmembrane transporter activity
AB849_RS06825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AB849_RS06835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AB849_RS06840	COG0564	pseudouridine synthase activity
AB849_RS06850	COG1028	Short-chain dehydrogenase reductase Sdr
AB849_RS06855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AB849_RS06855	COG4499	WXG100 protein secretion system (Wss), protein YukC
AB849_RS06860	COG3949	Membrane
AB849_RS06865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AB849_RS06885	COG1937	Protein conserved in bacteria
AB849_RS06895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AB849_RS06900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AB849_RS06905	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AB849_RS06910	COG2096	Adenosyltransferase
AB849_RS06915	COG1393	Belongs to the ArsC family
AB849_RS06920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AB849_RS06925	COG0509	glycine decarboxylation via glycine cleavage system
AB849_RS06935	COG0572	uridine kinase
AB849_RS06940	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AB849_RS06950	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AB849_RS06955	COG1242	4 iron, 4 sulfur cluster binding
AB849_RS06960	COG0561	phosphatase activity
AB849_RS06965	COG1253	flavin adenine dinucleotide binding
AB849_RS06995	COG0824	Thioesterase
AB849_RS07025	COG1228	amidohydrolase
AB849_RS07030	COG0010	Belongs to the arginase family
AB849_RS07035	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AB849_RS07045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AB849_RS07050	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AB849_RS07055	COG1185	polyribonucleotide nucleotidyltransferase activity
AB849_RS07065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AB849_RS07070	COG1414	Transcriptional regulator
AB849_RS07075	COG1349	DNA-binding transcription factor activity
AB849_RS07080	COG0602	queuosine metabolic process
AB849_RS07085	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AB849_RS07095	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AB849_RS07115	COG3314	Sporulation integral membrane protein YlbJ
AB849_RS07120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AB849_RS07125	COG1191	sigma factor activity
AB849_RS07135	COG2002	toxin-antitoxin pair type II binding
AB849_RS07140	COG1024	Enoyl-CoA hydratase
AB849_RS07165	COG1271	oxidase subunit
AB849_RS07170	COG1294	oxidase, subunit
AB849_RS07190	COG1301	dicarboxylic acid transport
AB849_RS07235	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AB849_RS07305	COG0482	sulfurtransferase activity
AB849_RS07310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AB849_RS07325	COG1392	Phosphate transport regulator
AB849_RS07330	COG0306	phosphate transporter
AB849_RS07335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AB849_RS07345	COG1104	cysteine desulfurase activity
AB849_RS07350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AB849_RS07360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AB849_RS07365	COG1376	ErfK ybiS ycfS ynhG family protein
AB849_RS07370	COG1376	ErfK ybiS ycfS ynhG family protein
AB849_RS07385	COG3409	Peptidoglycan-binding domain 1 protein
AB849_RS07385	COG3773	Cell wall hydrolase
AB849_RS07395	COG0179	Fumarylacetoacetate (FAA) hydrolase
AB849_RS07400	COG0460	homoserine dehydrogenase
AB849_RS07405	COG3620	sequence-specific DNA binding
AB849_RS07410	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AB849_RS07420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AB849_RS07425	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AB849_RS07430	COG0506	proline dehydrogenase activity
AB849_RS07435	COG1012	belongs to the aldehyde dehydrogenase family
AB849_RS07445	COG2851	Citrate transporter
AB849_RS07455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AB849_RS07470	COG1609	Transcriptional regulator
AB849_RS07475	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AB849_RS07480	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AB849_RS07485	COG1012	belongs to the aldehyde dehydrogenase family
AB849_RS07500	COG3773	Cell wall hydrolase
AB849_RS07515	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AB849_RS07525	COG0175	sulfate reduction
AB849_RS07530	COG2046	Belongs to the sulfate adenylyltransferase family
AB849_RS07535	COG0730	response to heat
AB849_RS07540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AB849_RS07545	COG1268	BioY protein
AB849_RS07560	COG0066	3-isopropylmalate dehydratase activity
AB849_RS07565	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AB849_RS07570	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AB849_RS07575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AB849_RS07585	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AB849_RS07590	COG0406	alpha-ribazole phosphatase activity
AB849_RS07600	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AB849_RS07605	COG2112	serine threonine protein kinase
AB849_RS07610	COG1832	CoA-binding protein
AB849_RS07650	COG0538	isocitrate dehydrogenase activity
AB849_RS07655	COG1472	Belongs to the glycosyl hydrolase 3 family
AB849_RS07675	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AB849_RS07675	COG1605	Chorismate mutase
AB849_RS07690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AB849_RS07700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AB849_RS07705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AB849_RS07710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AB849_RS07715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AB849_RS07725	COG0574	Belongs to the PEP-utilizing enzyme family
AB849_RS07725	COG3848	Pyruvate phosphate dikinase
AB849_RS07730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AB849_RS07735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AB849_RS07750	COG0406	alpha-ribazole phosphatase activity
AB849_RS07760	COG3604	Transcriptional regulator
AB849_RS07770	COG1028	Short-chain dehydrogenase reductase Sdr
AB849_RS07790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AB849_RS07800	COG1126	abc transporter atp-binding protein
AB849_RS07805	COG1956	GAF domain-containing protein
AB849_RS07815	COG2190	(PTS) system
AB849_RS07820	COG1363	Peptidase, m42
AB849_RS07830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AB849_RS07835	COG2066	Belongs to the glutaminase family
AB849_RS07840	COG4838	Belongs to the UPF0358 family
AB849_RS07845	COG0387	Pfam Sodium calcium exchanger
AB849_RS07855	COG1302	Protein conserved in bacteria
AB849_RS07865	COG1473	amidohydrolase
AB849_RS07870	COG0517	IMP dehydrogenase activity
AB849_RS07880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AB849_RS07900	COG1404	Belongs to the peptidase S8 family
AB849_RS07905	COG2239	Acts as a magnesium transporter
AB849_RS07925	COG3679	Belongs to the UPF0342 family
AB849_RS07930	COG4471	UPF0298 protein
AB849_RS07945	COG3339	Conserved Protein
AB849_RS07950	COG2894	cell division
AB849_RS07975	COG1757	Na H antiporter
AB849_RS07990	COG2050	protein possibly involved in aromatic compounds catabolism
AB849_RS07995	COG1024	Enoyl-CoA hydratase
AB849_RS08000	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AB849_RS08005	COG1250	3-hydroxyacyl-CoA dehydrogenase
AB849_RS08010	COG1250	3-hydroxyacyl-CoA dehydrogenase
AB849_RS08015	COG0183	Belongs to the thiolase family
AB849_RS08025	COG3396	Phenylacetate-CoA oxygenase
AB849_RS08040	COG2151	metal-sulfur cluster biosynthetic enzyme
AB849_RS08045	COG1012	belongs to the aldehyde dehydrogenase family
AB849_RS08050	COG2070	2-Nitropropane dioxygenase
AB849_RS08055	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AB849_RS08060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AB849_RS08080	COG3546	catalase activity
AB849_RS08100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AB849_RS08120	COG0768	penicillin binding
AB849_RS08130	COG0688	phosphatidylethanolamine metabolic process
AB849_RS08135	COG0705	Rhomboid family
AB849_RS08140	COG0477	Major facilitator Superfamily
AB849_RS08150	COG1012	belongs to the aldehyde dehydrogenase family
AB849_RS08155	COG0673	inositol 2-dehydrogenase activity
AB849_RS08160	COG0154	amidase activity
AB849_RS08170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AB849_RS08185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AB849_RS08190	COG1490	D-aminoacyl-tRNA deacylase activity
AB849_RS08195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AB849_RS08200	COG2363	Small membrane protein
AB849_RS08210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AB849_RS08225	COG5577	PFAM Coat F domain
AB849_RS08245	COG1959	2 iron, 2 sulfur cluster binding
AB849_RS08250	COG1104	cysteine desulfurase activity
AB849_RS08260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AB849_RS08280	COG0628	permease
AB849_RS08285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AB849_RS08290	COG4472	Bacterial protein of unknown function (DUF965)
AB849_RS08300	COG3906	Belongs to the UPF0473 family
AB849_RS08305	COG3906	Belongs to the UPF0473 family
AB849_RS08310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AB849_RS08315	COG0768	penicillin binding
AB849_RS08330	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AB849_RS08335	COG1914	H( )-stimulated, divalent metal cation uptake system
AB849_RS08340	COG0788	formyltetrahydrofolate deformylase activity
AB849_RS08345	COG0475	glutathione-regulated potassium exporter activity
AB849_RS08345	COG0569	domain protein
AB849_RS08350	COG3973	AAA domain
AB849_RS08355	COG1609	Transcriptional regulator
AB849_RS08360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AB849_RS08365	COG1869	D-ribose catabolic process
AB849_RS08370	COG1129	ABC transporter
AB849_RS08375	COG1172	Belongs to the binding-protein-dependent transport system permease family
AB849_RS08380	COG1879	ABC-type sugar transport system periplasmic component
AB849_RS08385	COG0431	NADPH-dependent FMN reductase
AB849_RS08390	COG0196	riboflavin kinase activity
AB849_RS08425	COG0681	Belongs to the peptidase S26 family
AB849_RS08460	COG2337	Toxic component of a toxin-antitoxin (TA) module
AB849_RS08470	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AB849_RS08480	COG1271	oxidase subunit
AB849_RS08485	COG1294	oxidase, subunit
AB849_RS08490	COG4988	ABC transporter
AB849_RS08495	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AB849_RS08505	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AB849_RS08515	COG3104	oligopeptide transport
AB849_RS08530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AB849_RS08540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AB849_RS08550	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AB849_RS08555	COG0656	L-ascorbic acid biosynthetic process
AB849_RS08560	COG0084	hydrolase, TatD family'
AB849_RS08565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AB849_RS08570	COG0436	Aminotransferase
AB849_RS08580	COG0006	proline dipeptidase activity
AB849_RS08585	COG1764	response to oxidative stress
AB849_RS08595	COG2211	Major facilitator Superfamily
AB849_RS08605	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AB849_RS08610	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AB849_RS08615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AB849_RS08620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AB849_RS08625	COG1713	HD superfamily hydrolase involved in NAD metabolism
AB849_RS08630	COG0799	negative regulation of ribosome biogenesis
AB849_RS08635	COG0495	leucyl-tRNA aminoacylation
AB849_RS08640	COG1555	photosystem II stabilization
AB849_RS08640	COG1596	polysaccharide export
AB849_RS08645	COG0626	cystathionine gamma-synthase activity
AB849_RS08650	COG0626	cystathionine gamma-synthase activity
AB849_RS08655	COG0717	Belongs to the dCTP deaminase family
AB849_RS08665	COG0658	competence protein
AB849_RS08665	COG2333	competence protein COMEC
AB849_RS08670	COG1595	DNA-templated transcription, initiation
AB849_RS08680	COG1466	dna polymerase III delta subunit
AB849_RS08695	COG4846	Membrane protein involved in cytochrome C biogenesis
AB849_RS08705	COG0268	Binds directly to 16S ribosomal RNA
AB849_RS08710	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AB849_RS08715	COG0860	N-Acetylmuramoyl-L-alanine amidase
AB849_RS08725	COG0481	GTPase activity
AB849_RS08730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AB849_RS08735	COG1420	regulation of RNA biosynthetic process
AB849_RS08740	COG0459	protein refolding
AB849_RS08760	COG2264	protein methyltransferase activity
AB849_RS08765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AB849_RS08770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AB849_RS08780	COG1283	sodium-dependent phosphate transmembrane transporter activity
AB849_RS08790	COG0537	adenosine 5'-monophosphoramidase activity
AB849_RS08795	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AB849_RS08800	COG1610	YqeY-like protein
AB849_RS08805	COG1030	water channel activity
AB849_RS08810	COG4864	UPF0365 protein
AB849_RS08835	COG1702	phosphate starvation-inducible protein PhoH
AB849_RS08840	COG1480	7TM receptor with intracellular HD hydrolase
AB849_RS08845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AB849_RS08850	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AB849_RS08855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AB849_RS08865	COG1381	Involved in DNA repair and RecF pathway recombination
AB849_RS08870	COG0752	glycyl-tRNA synthetase alpha subunit
AB849_RS08875	COG0751	glycine-tRNA ligase activity
AB849_RS08885	COG0517	IMP dehydrogenase activity
AB849_RS08890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AB849_RS08895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AB849_RS08895	COG0574	Belongs to the PEP-utilizing enzyme family
AB849_RS08900	COG0358	DNA primase activity
AB849_RS08905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AB849_RS08910	COG1960	acyl-CoA dehydrogenase activity
AB849_RS08915	COG0318	PFAM AMP-dependent synthetase and ligase
AB849_RS08925	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AB849_RS08935	COG2384	SAM-dependent methyltransferase
AB849_RS08940	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AB849_RS08955	COG1363	Peptidase, m42
AB849_RS08960	COG0586	Pfam SNARE associated Golgi protein
AB849_RS08965	COG0456	acetyltransferase
AB849_RS08970	COG0352	thiamine-phosphate diphosphorylase activity
AB849_RS08985	COG2022	thiamine diphosphate biosynthetic process
AB849_RS08990	COG0772	Belongs to the SEDS family
AB849_RS08995	COG0772	Belongs to the SEDS family
AB849_RS09005	COG0475	glutathione-regulated potassium exporter activity
AB849_RS09010	COG2738	Putative neutral zinc metallopeptidase
AB849_RS09020	COG3599	regulation of cell shape
AB849_RS09025	COG4166	transmembrane transport
AB849_RS09030	COG4709	membrane
AB849_RS09040	COG4122	O-methyltransferase activity
AB849_RS09050	COG0288	reversible hydration of carbon dioxide
AB849_RS09055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AB849_RS09065	COG1104	cysteine desulfurase activity
AB849_RS09070	COG0301	tRNA thio-modification
AB849_RS09075	COG4187	Peptidase family M20/M25/M40
AB849_RS09080	COG0861	Integral membrane protein TerC family
AB849_RS09095	COG1459	type II secretion system
AB849_RS09100	COG4537	Required for transformation and DNA binding
AB849_RS09130	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AB849_RS09135	COG2155	Conserved Protein
AB849_RS09140	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AB849_RS09150	COG2720	vancomycin resistance protein
AB849_RS09155	COG3583	domain protein
AB849_RS09155	COG3584	3D domain protein
AB849_RS09175	COG0613	PHP domain protein
AB849_RS09185	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AB849_RS09230	COG2390	Transcriptional regulator
AB849_RS09240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AB849_RS09255	COG5505	Protein of unknown function (DUF819)
AB849_RS09270	COG0671	phosphoesterase, PA-phosphatase related
AB849_RS09295	COG1982	Orn Lys Arg decarboxylase major
AB849_RS09300	COG4493	Belongs to the UPF0637 family
AB849_RS09310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AB849_RS09315	COG0584	glycerophosphoryl diester phosphodiesterase
AB849_RS09320	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AB849_RS09345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AB849_RS09350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AB849_RS09355	COG0785	Cytochrome C biogenesis protein
AB849_RS09365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AB849_RS09370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AB849_RS09380	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AB849_RS09390	COG1024	Enoyl-CoA hydratase
AB849_RS09400	COG0454	-acetyltransferase
AB849_RS09405	COG0439	Biotin carboxylase
AB849_RS09410	COG0511	ligase activity, forming carbon-carbon bonds
AB849_RS09415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AB849_RS09420	COG1024	Enoyl-CoA hydratase
AB849_RS09425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AB849_RS09430	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AB849_RS09440	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AB849_RS09445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AB849_RS09450	COG2001	Belongs to the MraZ family
AB849_RS09455	COG0275	rRNA processing
AB849_RS09465	COG0768	penicillin binding
AB849_RS09470	COG0768	penicillin binding
AB849_RS09475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AB849_RS09480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AB849_RS09485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AB849_RS09490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AB849_RS09495	COG0772	Belongs to the SEDS family
AB849_RS09500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AB849_RS09505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AB849_RS09510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AB849_RS09520	COG0849	cell division
AB849_RS09525	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AB849_RS09535	COG1191	sigma factor activity
AB849_RS09540	COG1191	sigma factor activity
AB849_RS09545	COG1873	PFAM PRC-barrel domain
AB849_RS09555	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AB849_RS09560	COG1799	cell septum assembly
AB849_RS09570	COG2302	S4 RNA-binding domain
AB849_RS09575	COG3599	regulation of cell shape
AB849_RS09580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AB849_RS09585	COG1113	amino acid transport
AB849_RS09590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AB849_RS09595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AB849_RS09600	COG0564	pseudouridine synthase activity
AB849_RS09605	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AB849_RS09610	COG2233	PERMEase
AB849_RS09620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AB849_RS09630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AB849_RS09635	COG0284	orotidine-5'-phosphate decarboxylase activity
AB849_RS09640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AB849_RS09645	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AB849_RS09650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AB849_RS09655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AB849_RS09665	COG0166	Belongs to the GPI family
AB849_RS09670	COG1363	Peptidase, m42
AB849_RS09675	COG0531	amino acid
AB849_RS09680	COG2244	polysaccharide biosynthetic process
AB849_RS09685	COG1561	YicC-like family, N-terminal region
AB849_RS09690	COG2052	Domain of unknown function (DUF370)
AB849_RS09695	COG0194	GDP metabolic process
AB849_RS09700	COG1758	RNA polymerase activity
AB849_RS09705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AB849_RS09710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AB849_RS09715	COG0242	peptide deformylase activity
AB849_RS09725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AB849_RS09725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AB849_RS09730	COG0697	spore germination
AB849_RS09735	COG0531	amino acid
AB849_RS09745	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AB849_RS09750	COG0631	protein serine/threonine phosphatase activity
AB849_RS09755	COG0515	serine threonine protein kinase
AB849_RS09755	COG2815	serine threonine protein kinase
AB849_RS09760	COG1162	GTPase activity
AB849_RS09765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AB849_RS09770	COG3859	Proton-coupled thiamine transporter YuaJ
AB849_RS09785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AB849_RS09790	COG1302	Protein conserved in bacteria
AB849_RS09795	COG1461	Dihydroxyacetone kinase
AB849_RS09805	COG1760	l-serine dehydratase
AB849_RS09810	COG1760	l-serine dehydratase
AB849_RS09815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AB849_RS09830	COG0742	ribosomal rna small subunit methyltransferase
AB849_RS09835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AB849_RS09840	COG3314	Sporulation integral membrane protein YlbJ
AB849_RS09845	COG1752	Esterase of the alpha-beta hydrolase superfamily
AB849_RS09850	COG3480	Lon protease (S16) C-terminal proteolytic domain
AB849_RS09855	COG1399	metal-binding, possibly nucleic acid-binding protein
AB849_RS09860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AB849_RS09865	COG1349	DNA-binding transcription factor activity
AB849_RS09870	COG0416	fatty acid biosynthetic process
AB849_RS09880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AB849_RS09885	COG1028	Short-chain dehydrogenase reductase Sdr
AB849_RS09890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AB849_RS09895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AB849_RS09920	COG1196	nuclear chromosome segregation
AB849_RS09925	COG0552	protein localization to endoplasmic reticulum
AB849_RS09930	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AB849_RS09935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AB849_RS09940	COG0228	four-way junction DNA binding
AB849_RS09950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AB849_RS09955	COG0336	Belongs to the RNA methyltransferase TrmD family
AB849_RS09960	COG0335	large ribosomal subunit rRNA binding
AB849_RS09965	COG0681	Belongs to the peptidase S26 family
AB849_RS09970	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AB849_RS09975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AB849_RS09980	COG0792	nuclease activity
AB849_RS09985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AB849_RS09995	COG0606	chelatase, subunit chli
AB849_RS10020	COG1525	nuclease
AB849_RS10030	COG0860	N-Acetylmuramoyl-L-alanine amidase
AB849_RS10035	COG1301	dicarboxylic acid transport
AB849_RS10040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AB849_RS10045	COG1454	alcohol dehydrogenase
AB849_RS10050	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AB849_RS10055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AB849_RS10060	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AB849_RS10070	COG1113	amino acid transport
AB849_RS10080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AB849_RS10090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AB849_RS10100	COG1757	Na H antiporter
AB849_RS10125	COG0045	succinate-CoA ligase (ADP-forming) activity
AB849_RS10130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AB849_RS10135	COG0758	DNA mediated transformation
AB849_RS10140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AB849_RS10145	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AB849_RS10150	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AB849_RS10160	COG0052	Belongs to the universal ribosomal protein uS2 family
AB849_RS10165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AB849_RS10170	COG0528	UMP kinase activity
AB849_RS10175	COG0233	cytoplasmic translational termination
AB849_RS10185	COG4589	Belongs to the CDS family
AB849_RS10190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AB849_RS10195	COG0750	zinc metalloprotease
AB849_RS10200	COG0442	prolyl-tRNA aminoacylation
AB849_RS10245	COG0517	IMP dehydrogenase activity
AB849_RS10245	COG4175	Glycine betaine
AB849_RS10255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AB849_RS10260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AB849_RS10265	COG1447	Phosphotransferase system cellobiose-specific component IIA
AB849_RS10275	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AB849_RS10280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AB849_RS10285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AB849_RS10290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AB849_RS10300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AB849_RS10305	COG1164	Oligoendopeptidase f
AB849_RS10320	COG0069	glutamate synthase activity
AB849_RS10325	COG0779	Required for maturation of 30S ribosomal subunits
AB849_RS10330	COG0195	Participates in both transcription termination and antitermination
AB849_RS10335	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AB849_RS10340	COG1358	cellular component organization or biogenesis
AB849_RS10345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AB849_RS10355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AB849_RS10360	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AB849_RS10365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AB849_RS10370	COG0196	riboflavin kinase activity
AB849_RS10375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AB849_RS10380	COG1185	polyribonucleotide nucleotidyltransferase activity
AB849_RS10385	COG0726	polysaccharide deacetylase
AB849_RS10390	COG0612	Peptidase, M16
AB849_RS10395	COG0756	dUTP diphosphatase activity
AB849_RS10410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AB849_RS10415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AB849_RS10420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AB849_RS10425	COG0527	aspartate kinase activity
AB849_RS10430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AB849_RS10435	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AB849_RS10445	COG3942	CHAP domain
AB849_RS10445	COG1388	LysM domain
AB849_RS10460	COG2076	Multidrug Resistance protein
AB849_RS10480	COG2376	Dihydroxyacetone kinase
AB849_RS10485	COG1461	Dihydroxyacetone kinase
AB849_RS10490	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AB849_RS10495	COG0740	serine-type endopeptidase activity
AB849_RS10505	COG1674	ftsk spoiiie
AB849_RS10510	COG0612	Peptidase, M16
AB849_RS10515	COG0612	Peptidase, M16
AB849_RS10520	COG0300	oxidoreductase activity
AB849_RS10535	COG1426	Protein conserved in bacteria
AB849_RS10545	COG1426	Protein conserved in bacteria
AB849_RS10550	COG1426	Protein conserved in bacteria
AB849_RS10555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AB849_RS10560	COG1546	Belongs to the CinA family
AB849_RS10560	COG1058	Belongs to the CinA family
AB849_RS10565	COG0513	Belongs to the DEAD box helicase family
AB849_RS10570	COG2151	metal-sulfur cluster biosynthetic enzyme
AB849_RS10575	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AB849_RS10580	COG2137	regulation of response to DNA damage stimulus
AB849_RS10605	COG1418	mRNA catabolic process
AB849_RS10610	COG1692	metallophosphoesterase
AB849_RS10615	COG2359	stage V sporulation protein S
AB849_RS10625	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AB849_RS10625	COG0674	pyruvate-flavodoxin oxidoreductase activity
AB849_RS10630	COG1013	pyruvate-flavodoxin oxidoreductase activity
AB849_RS10635	COG1234	tRNA 3'-trailer cleavage
AB849_RS10640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AB849_RS10645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AB849_RS10650	COG4550	Control of competence regulator ComK, YlbF/YmcA
AB849_RS10665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AB849_RS10675	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AB849_RS10680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AB849_RS10685	COG2521	methyltransferase
AB849_RS10685	COG2136	Putative SAM-dependent methyltransferase
AB849_RS10690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AB849_RS10695	COG1923	regulation of RNA biosynthetic process
AB849_RS10700	COG0464	growth
AB849_RS10705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AB849_RS10710	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AB849_RS10720	COG0789	Transcriptional regulator
AB849_RS10725	COG0174	glutamine synthetase
AB849_RS10735	COG1737	Transcriptional regulator
AB849_RS10750	COG0561	phosphatase activity
AB849_RS10760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AB849_RS10775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AB849_RS10780	COG1845	cytochrome c oxidase, subunit III
AB849_RS10785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AB849_RS10790	COG0109	protoheme IX farnesyltransferase activity
AB849_RS10800	COG0662	Cupin 2, conserved barrel domain protein
AB849_RS10805	COG2226	methyltransferase
AB849_RS10810	COG0535	radical SAM domain protein
AB849_RS10820	COG2151	metal-sulfur cluster biosynthetic enzyme
AB849_RS10850	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AB849_RS10855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AB849_RS10860	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AB849_RS10875	COG2318	DinB family
AB849_RS10885	COG0017	Asparaginyl-tRNA synthetase
AB849_RS10890	COG3935	DnaD domain protein
AB849_RS10895	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AB849_RS10900	COG1737	Transcriptional regulator
AB849_RS10905	COG1263	PTS System
AB849_RS10905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AB849_RS10910	COG2323	membrane
AB849_RS10915	COG1979	alcohol dehydrogenase
AB849_RS10920	COG1114	Component of the transport system for branched-chain amino acids
AB849_RS10925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AB849_RS10945	COG2608	mercury ion transmembrane transporter activity
AB849_RS10950	COG2217	Heavy metal translocating P-type atpase
AB849_RS10955	COG1024	Enoyl-CoA hydratase
AB849_RS10965	COG0300	oxidoreductase activity
AB849_RS10985	COG1510	regulation of RNA biosynthetic process
AB849_RS10990	COG1012	belongs to the aldehyde dehydrogenase family
AB849_RS10995	COG1454	alcohol dehydrogenase
AB849_RS11005	COG0813	purine-nucleoside phosphorylase activity
AB849_RS11010	COG0778	Nitroreductase
AB849_RS11015	COG0456	acetyltransferase
AB849_RS11040	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AB849_RS11045	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AB849_RS11055	COG3336	cytochrome c oxidase
AB849_RS11075	COG1054	Belongs to the UPF0176 family
AB849_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
AB849_RS11095	COG2226	methyltransferase
AB849_RS11110	COG0346	lactoylglutathione lyase activity
AB849_RS11150	COG0346	lactoylglutathione lyase activity
AB849_RS11170	COG2032	superoxide dismutase activity
AB849_RS11180	COG1741	Belongs to the pirin family
AB849_RS11185	COG0655	NAD(P)H dehydrogenase (quinone) activity
AB849_RS11225	COG1309	transcriptional regulator
AB849_RS11255	COG1131	(ABC) transporter
AB849_RS11260	COG1609	Transcriptional regulator
AB849_RS11295	COG1280	lysine exporter protein (LysE YggA)
AB849_RS11335	COG1917	Cupin 2, conserved barrel domain protein
AB849_RS11335	COG4977	sequence-specific DNA binding
AB849_RS11340	COG0367	asparagine synthase
AB849_RS11345	COG0789	Transcriptional regulator
AB849_RS11380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AB849_RS11385	COG0789	Transcriptional regulator
AB849_RS11390	COG0019	diaminopimelate decarboxylase activity
AB849_RS11395	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AB849_RS11410	COG0697	spore germination
AB849_RS11415	COG4224	UPF0291 protein
AB849_RS11420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AB849_RS11425	COG1363	Peptidase, m42
AB849_RS11445	COG1619	proteins homologs of microcin C7 resistance protein MccF
AB849_RS11450	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AB849_RS11455	COG0604	alcohol dehydrogenase
AB849_RS11480	COG0730	response to heat
AB849_RS11510	COG1028	Short-chain dehydrogenase reductase Sdr
AB849_RS11515	COG2223	nitrite transmembrane transporter activity
AB849_RS11525	COG5564	TIM-barrel signal transduction protein
AB849_RS11540	COG1054	Belongs to the UPF0176 family
AB849_RS11550	COG1024	Enoyl-CoA hydratase
AB849_RS11555	COG0183	Belongs to the thiolase family
AB849_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
AB849_RS11565	COG1022	Amp-dependent synthetase and ligase
AB849_RS11575	COG1960	acyl-CoA dehydrogenase activity
AB849_RS11590	COG4974	Belongs to the 'phage' integrase family
AB849_RS11595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AB849_RS11605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AB849_RS11610	COG1250	3-hydroxyacyl-CoA dehydrogenase
AB849_RS11615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AB849_RS11635	COG0402	S-adenosylhomocysteine deaminase activity
AB849_RS11655	COG1793	dna ligase
AB849_RS11660	COG0363	glucosamine-6-phosphate deaminase activity
AB849_RS11665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AB849_RS11670	COG2807	transmembrane transport
AB849_RS11675	COG0531	amino acid
AB849_RS11685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AB849_RS11690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AB849_RS11710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AB849_RS11715	COG1187	pseudouridine synthase activity
AB849_RS11720	COG1113	amino acid transport
AB849_RS11735	COG2391	methyltransferase activity
AB849_RS11750	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AB849_RS11765	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AB849_RS11770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AB849_RS11775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AB849_RS11820	COG0438	transferase activity, transferring glycosyl groups
AB849_RS11825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AB849_RS11830	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AB849_RS11840	COG1694	Mazg nucleotide pyrophosphohydrolase
AB849_RS11845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AB849_RS11865	COG4347	Protein of unknown function (DUF1405)
AB849_RS11880	COG0723	plastoquinol--plastocyanin reductase activity
AB849_RS11890	COG5582	Belongs to the UPF0302 family
AB849_RS11905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AB849_RS11910	COG0287	Prephenate dehydrogenase
AB849_RS11915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AB849_RS11920	COG0159	tryptophan synthase activity
AB849_RS11925	COG0133	tryptophan synthase activity
AB849_RS11930	COG0135	phosphoribosylanthranilate isomerase activity
AB849_RS11935	COG0134	indole-3-glycerol-phosphate synthase activity
AB849_RS11940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AB849_RS11950	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AB849_RS11955	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AB849_RS11960	COG0105	UTP biosynthetic process
AB849_RS11970	COG0109	protoheme IX farnesyltransferase activity
AB849_RS11980	COG0142	geranyltranstransferase activity
AB849_RS12000	COG0302	gtp cyclohydrolase
AB849_RS12005	COG0776	regulation of translation
AB849_RS12010	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AB849_RS12030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AB849_RS12035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AB849_RS12040	COG1160	GTP binding
AB849_RS12060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AB849_RS12065	COG2959	enzyme of heme biosynthesis
AB849_RS12075	COG0252	asparaginase activity
AB849_RS12080	COG0492	ferredoxin-NADP+ reductase activity
AB849_RS12085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AB849_RS12090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AB849_RS12095	COG4862	establishment of competence for transformation
AB849_RS12110	COG1054	Belongs to the UPF0176 family
AB849_RS12120	COG1725	Transcriptional regulator
AB849_RS12130	COG0210	DNA helicase
AB849_RS12135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AB849_RS12140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AB849_RS12145	COG4221	oxidoreductase activity
AB849_RS12150	COG5002	protein histidine kinase activity
AB849_RS12155	COG0745	RESPONSE REGULATOR receiver
AB849_RS12160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AB849_RS12165	COG1333	cytochrome c biogenesis protein
AB849_RS12170	COG1187	pseudouridine synthase activity
AB849_RS12175	COG0700	Nucleoside recognition
AB849_RS12180	COG2715	membrane protein required for spore maturation
AB849_RS12185	COG1686	Belongs to the peptidase S11 family
AB849_RS12190	COG3874	Sporulation protein YtfJ
AB849_RS12200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AB849_RS12200	COG2213	PTS system mannitol-specific
AB849_RS12205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AB849_RS12210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AB849_RS12215	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AB849_RS12220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AB849_RS12220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AB849_RS12230	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AB849_RS12230	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AB849_RS12235	COG1612	heme a metabolic process
AB849_RS12260	COG2172	sigma factor antagonist activity
AB849_RS12265	COG1366	Belongs to the anti-sigma-factor antagonist family
AB849_RS12270	COG1686	Belongs to the peptidase S11 family
AB849_RS12285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AB849_RS12295	COG0686	Belongs to the AlaDH PNT family
AB849_RS12300	COG0735	belongs to the Fur family
AB849_RS12305	COG1300	Membrane
AB849_RS12315	COG1379	DNA repair
AB849_RS12320	COG0494	nUDIX hydrolase
AB849_RS12325	COG3546	catalase activity
AB849_RS12345	COG2217	Heavy metal translocating P-type atpase
AB849_RS12350	COG2195	Cleaves the N-terminal amino acid of tripeptides
AB849_RS12355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AB849_RS12360	COG0346	lactoylglutathione lyase activity
AB849_RS12365	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AB849_RS12365	COG1703	isobutyryl-CoA mutase activity
AB849_RS12365	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AB849_RS12370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AB849_RS12370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AB849_RS12375	COG0508	dehydrogenase complex catalyzes the overall conversion of
AB849_RS12380	COG0022	dehydrogenase e1 component
AB849_RS12385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AB849_RS12390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AB849_RS12395	COG3426	butyrate kinase activity
AB849_RS12405	COG0280	phosphate acetyltransferase
AB849_RS12410	COG3290	protein histidine kinase activity
AB849_RS12410	COG3829	transcription factor binding
AB849_RS12430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AB849_RS12440	COG0745	RESPONSE REGULATOR receiver
AB849_RS12470	COG0750	zinc metalloprotease
AB849_RS12475	COG0497	DNA recombination
AB849_RS12480	COG1438	arginine binding
AB849_RS12485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AB849_RS12495	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AB849_RS12500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AB849_RS12505	COG0142	geranyltranstransferase activity
AB849_RS12510	COG1722	exodeoxyribonuclease VII activity
AB849_RS12515	COG1570	exodeoxyribonuclease VII activity
AB849_RS12520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AB849_RS12525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AB849_RS12530	COG1302	Protein conserved in bacteria
AB849_RS12535	COG0439	Biotin carboxylase
AB849_RS12540	COG0511	ligase activity, forming carbon-carbon bonds
AB849_RS12580	COG3854	ATPases associated with a variety of cellular activities
AB849_RS12590	COG2814	Major facilitator Superfamily
AB849_RS12595	COG1809	phosphosulfolactate synthase activity
AB849_RS12600	COG2707	UPF0756 membrane protein
AB849_RS12610	COG1413	lyase activity
AB849_RS12615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AB849_RS12620	COG0006	proline dipeptidase activity
AB849_RS12630	COG3872	metal-dependent enzyme
AB849_RS12640	COG1752	Esterase of the alpha-beta hydrolase superfamily
AB849_RS12645	COG1321	iron dependent repressor
AB849_RS12650	COG0431	NADPH-dependent FMN reductase
AB849_RS12660	COG2986	histidine ammonia-lyase
AB849_RS12685	COG0095	Lipoate-protein ligase
AB849_RS12690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AB849_RS12695	COG2190	(PTS) system
AB849_RS12695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AB849_RS12695	COG1263	PTS System
AB849_RS12700	COG3711	transcriptional antiterminator
AB849_RS12710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AB849_RS12715	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AB849_RS12720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AB849_RS12725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AB849_RS12740	COG1126	abc transporter atp-binding protein
AB849_RS12745	COG0765	amino acid transport
AB849_RS12750	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AB849_RS12755	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AB849_RS12760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AB849_RS12770	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AB849_RS12780	COG1132	(ABC) transporter
AB849_RS12785	COG1132	(ABC) transporter
AB849_RS12790	COG1217	gtp-binding protein TYPA
AB849_RS12795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AB849_RS12805	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AB849_RS12815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AB849_RS12820	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AB849_RS12820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AB849_RS12835	COG2244	polysaccharide biosynthetic process
AB849_RS12840	COG2323	membrane
AB849_RS12850	COG1862	Preprotein translocase
AB849_RS12855	COG0343	queuine tRNA-ribosyltransferase activity
AB849_RS12860	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AB849_RS12870	COG2255	four-way junction helicase activity
AB849_RS12875	COG0632	four-way junction helicase activity
AB849_RS12880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AB849_RS12885	COG0217	transcriptional regulatory protein
AB849_RS12895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AB849_RS12895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AB849_RS12915	COG1131	(ABC) transporter
AB849_RS12930	COG0077	Prephenate dehydratase
AB849_RS12935	COG0083	homoserine kinase activity
AB849_RS12940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AB849_RS12945	COG4492	Belongs to the UPF0735 family
AB849_RS12950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AB849_RS12960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AB849_RS12970	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AB849_RS12975	COG2868	ribosomal protein
AB849_RS12980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AB849_RS12985	COG1994	Peptidase M50
AB849_RS12995	COG2894	cell division
AB849_RS13000	COG0850	regulation of cytokinetic process
AB849_RS13020	COG1077	Cell shape determining protein MreB Mrl
AB849_RS13025	COG2003	Belongs to the UPF0758 family
AB849_RS13030	COG0424	maF-like protein
AB849_RS13040	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AB849_RS13055	COG1131	(ABC) transporter
AB849_RS13070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AB849_RS13075	COG0285	dihydrofolate synthase activity
AB849_RS13080	COG0525	valine-tRNA ligase activity
AB849_RS13090	COG1388	LysM domain
AB849_RS13095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AB849_RS13100	COG0113	porphobilinogen synthase activity
AB849_RS13110	COG0181	hydroxymethylbilane synthase activity
AB849_RS13120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AB849_RS13125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AB849_RS13130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AB849_RS13135	COG1116	anion transmembrane transporter activity
AB849_RS13140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AB849_RS13150	COG0024	Methionine aminopeptidase
AB849_RS13155	COG1181	Belongs to the D-alanine--D-alanine ligase family
AB849_RS13160	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AB849_RS13170	COG1067	ATP-dependent peptidase activity
AB849_RS13170	COG0470	DNA polymerase III
AB849_RS13180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AB849_RS13185	COG0740	serine-type endopeptidase activity
AB849_RS13190	COG0544	peptidyl-prolyl cis-trans isomerase activity