locus-tag	class	description
EG886_RS00010	COG0592	DNA-directed DNA polymerase activity
EG886_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EG886_RS00030	COG0187	DNA topoisomerase II activity
EG886_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EG886_RS00050	COG0516	GMP reductase activity
EG886_RS00050	COG0517	IMP dehydrogenase activity
EG886_RS00060	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EG886_RS00065	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EG886_RS00070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EG886_RS00085	COG0745	RESPONSE REGULATOR receiver
EG886_RS00090	COG5002	protein histidine kinase activity
EG886_RS00105	COG1733	regulation of RNA biosynthetic process
EG886_RS00125	COG0367	asparagine synthase
EG886_RS00145	COG3443	Belongs to the bacterial solute-binding protein 9 family
EG886_RS00145	COG0803	Belongs to the bacterial solute-binding protein 9 family
EG886_RS00150	COG1121	(ABC) transporter
EG886_RS00155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EG886_RS00160	COG0735	belongs to the Fur family
EG886_RS00165	COG0590	tRNA wobble adenosine to inosine editing
EG886_RS00185	COG0470	DNA polymerase III
EG886_RS00205	COG3852	Histidine kinase
EG886_RS00210	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EG886_RS00215	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EG886_RS00220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EG886_RS00275	COG1982	Orn Lys Arg decarboxylase major
EG886_RS00280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EG886_RS00285	COG1774	PSP1 C-terminal conserved region
EG886_RS00290	COG4467	Involved in initiation control of chromosome replication
EG886_RS00295	COG2827	Endonuclease containing a URI domain
EG886_RS00300	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EG886_RS00305	COG1263	PTS System
EG886_RS00305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EG886_RS00305	COG2190	(PTS) system
EG886_RS00310	COG2002	toxin-antitoxin pair type II binding
EG886_RS00335	COG0084	hydrolase, TatD family'
EG886_RS00345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EG886_RS00355	COG4466	Protein conserved in bacteria
EG886_RS00365	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EG886_RS00370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EG886_RS00375	COG0251	oxidation-reduction process
EG886_RS00380	COG2088	sporulation resulting in formation of a cellular spore
EG886_RS00385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EG886_RS00405	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EG886_RS00415	COG2002	toxin-antitoxin pair type II binding
EG886_RS00420	COG2244	polysaccharide biosynthetic process
EG886_RS00425	COG3956	TIGRFAM MazG family protein
EG886_RS00430	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EG886_RS00460	COG3557	Belongs to the UPF0374 family
EG886_RS00465	COG2208	phosphoserine phosphatase activity
EG886_RS00470	COG0037	tRNA processing
EG886_RS00475	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EG886_RS00480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EG886_RS00485	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EG886_RS00495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EG886_RS00500	COG0512	Glutamine amidotransferase of anthranilate synthase
EG886_RS00505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EG886_RS00510	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EG886_RS00515	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EG886_RS00520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EG886_RS00525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EG886_RS00555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EG886_RS00585	COG2304	oxidoreductase activity
EG886_RS00620	COG0739	heme binding
EG886_RS00625	COG2270	Major facilitator Superfamily
EG886_RS00650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EG886_RS00655	COG1136	(ABC) transporter
EG886_RS00660	COG0577	efflux transmembrane transporter activity
EG886_RS00675	COG2197	response regulator
EG886_RS00680	COG4585	Histidine kinase
EG886_RS00700	COG1285	pathogenesis
EG886_RS00710	COG3880	PFAM UvrB UvrC protein
EG886_RS00715	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EG886_RS00720	COG0542	response to heat
EG886_RS00725	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EG886_RS00730	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EG886_RS00735	COG1183	phosphatidylcholine synthase activity
EG886_RS00745	COG1329	Transcriptional regulator
EG886_RS00750	COG4956	integral membrane protein (PIN domain superfamily)
EG886_RS00755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EG886_RS00765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EG886_RS00770	COG1045	serine acetyltransferase
EG886_RS00775	COG0215	cysteine-tRNA ligase activity
EG886_RS00780	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
EG886_RS00785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EG886_RS00800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EG886_RS00810	COG0250	Participates in transcription elongation, termination and antitermination
EG886_RS00815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EG886_RS00820	COG0081	regulation of translation
EG886_RS00825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EG886_RS00830	COG0222	ribosome binding
EG886_RS00835	COG2813	Specifically methylates the guanine in position
EG886_RS00840	COG0085	RNA polymerase activity
EG886_RS00845	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EG886_RS00850	COG1358	cellular component organization or biogenesis
EG886_RS00855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EG886_RS00860	COG0049	tRNA binding
EG886_RS00865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EG886_RS00870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EG886_RS00895	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EG886_RS00900	COG0088	Forms part of the polypeptide exit tunnel
EG886_RS00905	COG0089	rRNA binding
EG886_RS00910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EG886_RS00915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EG886_RS00920	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EG886_RS00925	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EG886_RS00930	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EG886_RS00935	COG0255	Belongs to the universal ribosomal protein uL29 family
EG886_RS00945	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EG886_RS00955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EG886_RS00960	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EG886_RS00965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EG886_RS00970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EG886_RS00975	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EG886_RS00980	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EG886_RS00990	COG0200	Binds to the 23S rRNA
EG886_RS00995	COG0201	protein transport
EG886_RS01000	COG0563	adenylate kinase activity
EG886_RS01005	COG0024	Methionine aminopeptidase
EG886_RS01015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EG886_RS01025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EG886_RS01030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EG886_RS01035	COG0202	RNA polymerase activity
EG886_RS01040	COG0203	ribosomal protein L17
EG886_RS01045	COG1122	ATPase activity
EG886_RS01050	COG1122	ATPase activity
EG886_RS01055	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EG886_RS01060	COG0101	tRNA pseudouridine synthase activity
EG886_RS01065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EG886_RS01070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EG886_RS01080	COG0860	N-Acetylmuramoyl-L-alanine amidase
EG886_RS01085	COG0489	protein tyrosine kinase activity
EG886_RS01095	COG2385	sporulation resulting in formation of a cellular spore
EG886_RS01095	COG2247	cell wall binding repeat
EG886_RS01110	COG0726	polysaccharide deacetylase
EG886_RS01250	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EG886_RS01255	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EG886_RS01265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EG886_RS01270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EG886_RS01275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EG886_RS01280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EG886_RS01290	COG4195	phage-related replication protein
EG886_RS01305	COG0398	Pfam SNARE associated Golgi protein
EG886_RS01325	COG1131	(ABC) transporter
EG886_RS01335	COG0736	holo-[acyl-carrier-protein] synthase activity
EG886_RS01340	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EG886_RS01340	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EG886_RS01345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EG886_RS01355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EG886_RS01360	COG0864	Transcriptional regulator
EG886_RS01365	COG2337	Toxic component of a toxin-antitoxin (TA) module
EG886_RS01370	COG2208	phosphoserine phosphatase activity
EG886_RS01380	COG2172	sigma factor antagonist activity
EG886_RS01385	COG1191	sigma factor activity
EG886_RS01390	COG2183	response to ionizing radiation
EG886_RS01400	COG3091	SprT-like family
EG886_RS01410	COG2084	Dehydrogenase
EG886_RS01485	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EG886_RS01490	COG0802	atpase or kinase
EG886_RS01495	COG1214	PFAM Peptidase M22, glycoprotease
EG886_RS01500	COG0456	acetyltransferase
EG886_RS01505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EG886_RS01510	COG0488	(ABC) transporter
EG886_RS01515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EG886_RS01520	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EG886_RS01530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EG886_RS01535	COG0459	protein refolding
EG886_RS01550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EG886_RS01555	COG0714	Associated with various cellular activities
EG886_RS01565	COG1305	Transglutaminase-like
EG886_RS01570	COG1305	Transglutaminase-like
EG886_RS01575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EG886_RS01575	COG0519	Catalyzes the synthesis of GMP from XMP
EG886_RS01580	COG2252	PERMEase
EG886_RS01635	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EG886_RS01640	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EG886_RS01645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EG886_RS01650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EG886_RS01655	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EG886_RS01660	COG0047	phosphoribosylformylglycinamidine synthase activity
EG886_RS01665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EG886_RS01670	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EG886_RS01675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EG886_RS01680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EG886_RS01695	COG0151	Belongs to the GarS family
EG886_RS01710	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EG886_RS01720	COG3584	3D domain protein
EG886_RS01725	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EG886_RS01730	COG0668	transmembrane transport
EG886_RS01735	COG1988	membrane-bound metal-dependent
EG886_RS01745	COG2720	vancomycin resistance protein
EG886_RS01750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EG886_RS01765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EG886_RS01770	COG3557	Belongs to the UPF0374 family
EG886_RS01780	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EG886_RS01785	COG1132	(ABC) transporter
EG886_RS01795	COG0109	protoheme IX farnesyltransferase activity
EG886_RS01800	COG2010	Cytochrome c
EG886_RS01800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EG886_RS01815	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EG886_RS01840	COG0596	Alpha beta hydrolase
EG886_RS01845	COG0067	glutamate synthase
EG886_RS01845	COG0070	glutamate synthase
EG886_RS01845	COG0069	glutamate synthase activity
EG886_RS01860	COG1131	(ABC) transporter
EG886_RS01865	COG2346	COG2346, Truncated hemoglobins
EG886_RS01870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EG886_RS01885	COG4326	sporulation control protein
EG886_RS01890	COG4555	ABC transporter
EG886_RS01925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EG886_RS01940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EG886_RS01945	COG0735	belongs to the Fur family
EG886_RS01960	COG0477	Major facilitator Superfamily
EG886_RS01985	COG0501	Belongs to the peptidase M48B family
EG886_RS02020	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EG886_RS02030	COG0517	IMP dehydrogenase activity
EG886_RS02030	COG0617	tRNA 3'-terminal CCA addition
EG886_RS02030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EG886_RS02045	COG2267	carboxylic ester hydrolase activity
EG886_RS02055	COG0396	ATPase activity
EG886_RS02060	COG0719	Fe-S assembly protein
EG886_RS02065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EG886_RS02070	COG0822	iron-sulfur transferase activity
EG886_RS02075	COG0719	Fe-S assembly protein
EG886_RS02080	COG1473	amidohydrolase
EG886_RS02085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EG886_RS02090	COG2171	N-acyltransferase activity
EG886_RS02105	COG1295	ribonuclease BN
EG886_RS02110	COG0628	permease
EG886_RS02120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EG886_RS02125	COG3162	membrane
EG886_RS02135	COG5505	Protein of unknown function (DUF819)
EG886_RS02145	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EG886_RS02155	COG1801	Protein of unknown function DUF72
EG886_RS02160	COG0730	response to heat
EG886_RS02165	COG0737	Belongs to the 5'-nucleotidase family
EG886_RS02175	COG3377	Domain of unknown function (DUF1805)
EG886_RS02180	COG0564	pseudouridine synthase activity
EG886_RS02185	COG1278	Cold shock
EG886_RS02195	COG0535	radical SAM domain protein
EG886_RS02210	COG1131	(ABC) transporter
EG886_RS02225	COG0714	Associated with various cellular activities
EG886_RS02260	COG3764	Sortase (surface protein transpeptidase)
EG886_RS02280	COG0433	COG0433 Predicted ATPase
EG886_RS02320	COG3424	synthase
EG886_RS02325	COG1755	Isoprenylcysteine carboxyl methyltransferase
EG886_RS02330	COG1115	amino acid carrier protein
EG886_RS02355	COG0444	Belongs to the ABC transporter superfamily
EG886_RS02360	COG4608	Belongs to the ABC transporter superfamily
EG886_RS02365	COG0747	negative chemotaxis
EG886_RS02370	COG0601	transmembrane transport
EG886_RS02375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EG886_RS02390	COG0673	inositol 2-dehydrogenase activity
EG886_RS02400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EG886_RS02435	COG0531	amino acid
EG886_RS02440	COG0739	heme binding
EG886_RS02445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EG886_RS02455	COG4470	Protein conserved in bacteria
EG886_RS02490	COG2445	Protein of unknown function DUF86
EG886_RS02500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EG886_RS02505	COG0647	UMP catabolic process
EG886_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
EG886_RS02525	COG2186	Transcriptional regulator
EG886_RS02540	COG4166	transmembrane transport
EG886_RS02545	COG4166	transmembrane transport
EG886_RS02550	COG0601	transmembrane transport
EG886_RS02555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EG886_RS02560	COG0444	Belongs to the ABC transporter superfamily
EG886_RS02565	COG4608	Belongs to the ABC transporter superfamily
EG886_RS02570	COG2318	DinB family
EG886_RS02575	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EG886_RS02580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EG886_RS02585	COG0626	cystathionine gamma-synthase activity
EG886_RS02595	COG4844	belongs to the
EG886_RS02605	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EG886_RS02615	COG0316	Belongs to the HesB IscA family
EG886_RS02625	COG0492	ferredoxin-NADP+ reductase activity
EG886_RS02630	COG1252	NADH dehydrogenase
EG886_RS02645	COG0300	oxidoreductase activity
EG886_RS02660	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EG886_RS02680	COG3858	chitin binding
EG886_RS02680	COG1388	LysM domain
EG886_RS02685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EG886_RS02710	COG0683	leucine binding
EG886_RS02780	COG0739	heme binding
EG886_RS02780	COG0741	lytic transglycosylase activity
EG886_RS02780	COG1196	nuclear chromosome segregation
EG886_RS02840	COG0318	PFAM AMP-dependent synthetase and ligase
EG886_RS02845	COG1231	oxidoreductase activity
EG886_RS02860	COG1757	Na H antiporter
EG886_RS02865	COG2226	methyltransferase
EG886_RS02875	COG2091	lysine biosynthetic process via aminoadipic acid
EG886_RS02880	COG0488	(ABC) transporter
EG886_RS02890	COG0584	glycerophosphoryl diester phosphodiesterase
EG886_RS02895	COG2226	methyltransferase
EG886_RS02935	COG0574	Belongs to the PEP-utilizing enzyme family
EG886_RS02935	COG3848	Pyruvate phosphate dikinase
EG886_RS02960	COG0500	methyltransferase
EG886_RS02970	COG2843	Capsule synthesis protein
EG886_RS02990	COG3253	May function as heme-dependent peroxidase
EG886_RS03005	COG1732	Glycine betaine
EG886_RS03020	COG0246	Mannitol dehydrogenase
EG886_RS03025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EG886_RS03030	COG3711	transcriptional antiterminator
EG886_RS03045	COG0640	Transcriptional regulator
EG886_RS03050	COG1113	amino acid transport
EG886_RS03055	COG1408	metallophosphoesterase
EG886_RS03060	COG0662	Cupin 2, conserved barrel domain protein
EG886_RS03065	COG4326	sporulation control protein
EG886_RS03090	COG0582	viral genome integration into host DNA
EG886_RS03095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EG886_RS03100	COG0697	spore germination
EG886_RS03120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EG886_RS03125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EG886_RS03135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EG886_RS03150	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EG886_RS03155	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EG886_RS03160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EG886_RS03165	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EG886_RS03270	COG3591	Belongs to the peptidase S1B family
EG886_RS03275	COG2217	Heavy metal translocating P-type atpase
EG886_RS03290	COG0668	transmembrane transport
EG886_RS03295	COG0477	Major facilitator Superfamily
EG886_RS03305	COG1611	Belongs to the LOG family
EG886_RS03315	COG1234	tRNA 3'-trailer cleavage
EG886_RS03325	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EG886_RS03340	COG0514	ATP-dependent DNA helicase (RecQ)
EG886_RS03345	COG0095	Lipoate-protein ligase
EG886_RS03355	COG2226	methyltransferase
EG886_RS03360	COG1309	transcriptional regulator
EG886_RS03365	COG3396	Phenylacetate-CoA oxygenase
EG886_RS03380	COG2151	metal-sulfur cluster biosynthetic enzyme
EG886_RS03385	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EG886_RS03395	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG886_RS03400	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG886_RS03405	COG0183	Belongs to the thiolase family
EG886_RS03410	COG1012	belongs to the aldehyde dehydrogenase family
EG886_RS03440	COG0328	RNA-DNA hybrid ribonuclease activity
EG886_RS03450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EG886_RS03460	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EG886_RS03470	COG2766	serine protein kinase
EG886_RS03475	COG2718	Belongs to the UPF0229 family
EG886_RS03500	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EG886_RS03510	COG0577	efflux transmembrane transporter activity
EG886_RS03515	COG1136	(ABC) transporter
EG886_RS03520	COG5002	protein histidine kinase activity
EG886_RS03525	COG0745	RESPONSE REGULATOR receiver
EG886_RS03530	COG3546	catalase activity
EG886_RS03535	COG4991	sh3 domain protein
EG886_RS03540	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EG886_RS03545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EG886_RS03550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EG886_RS03555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EG886_RS03565	COG1122	ATPase activity
EG886_RS03575	COG0352	thiamine-phosphate diphosphorylase activity
EG886_RS03580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EG886_RS03585	COG2104	thiamine diphosphate biosynthetic process
EG886_RS03590	COG2022	thiamine diphosphate biosynthetic process
EG886_RS03595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EG886_RS03600	COG0351	phosphomethylpyrimidine kinase
EG886_RS03605	COG0352	thiamine-phosphate diphosphorylase activity
EG886_RS03615	COG2176	DNA-directed DNA polymerase activity
EG886_RS03630	COG1484	DNA-dependent DNA replication
EG886_RS03635	COG3973	AAA domain
EG886_RS03640	COG1657	PFAM Prenyltransferase squalene oxidase
EG886_RS03650	COG0456	acetyltransferase
EG886_RS03660	COG0789	Transcriptional regulator
EG886_RS03675	COG1595	DNA-templated transcription, initiation
EG886_RS03710	COG0494	nUDIX hydrolase
EG886_RS03720	COG0395	ABC-type sugar transport system, permease component
EG886_RS03725	COG1175	transmembrane transport
EG886_RS03730	COG1653	transport
EG886_RS03735	COG0574	Belongs to the PEP-utilizing enzyme family
EG886_RS03735	COG3848	Pyruvate phosphate dikinase
EG886_RS03760	COG0300	oxidoreductase activity
EG886_RS03785	COG0411	ABC transporter
EG886_RS03810	COG3844	kynureninase activity
EG886_RS03830	COG2239	Acts as a magnesium transporter
EG886_RS03835	COG2719	SpoVR family
EG886_RS03850	COG0189	ligase activity
EG886_RS03855	COG0189	ligase activity
EG886_RS03860	COG0189	ligase activity
EG886_RS03865	COG0189	ligase activity
EG886_RS03880	COG4109	DRTGG domain
EG886_RS03900	COG0587	DNA-directed DNA polymerase activity
EG886_RS03905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EG886_RS03915	COG0281	malic enzyme
EG886_RS03920	COG2186	Transcriptional regulator
EG886_RS03925	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EG886_RS03930	COG0825	malonyl-CoA metabolic process
EG886_RS03935	COG0205	6-phosphofructokinase activity
EG886_RS03960	COG0824	Thioesterase
EG886_RS03965	COG3030	protein affecting phage T7 exclusion by the F plasmid
EG886_RS03970	COG0628	permease
EG886_RS03975	COG0372	Belongs to the citrate synthase family
EG886_RS03980	COG0538	isocitrate dehydrogenase activity
EG886_RS03985	COG0039	L-malate dehydrogenase activity
EG886_RS03995	COG0745	RESPONSE REGULATOR receiver
EG886_RS04000	COG5002	protein histidine kinase activity
EG886_RS04005	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EG886_RS04010	COG0573	inorganic phosphate transmembrane transporter activity
EG886_RS04015	COG0573	inorganic phosphate transmembrane transporter activity
EG886_RS04020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EG886_RS04025	COG0730	response to heat
EG886_RS04030	COG1959	2 iron, 2 sulfur cluster binding
EG886_RS04035	COG1902	pentaerythritol trinitrate reductase activity
EG886_RS04045	COG2226	methyltransferase
EG886_RS04055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EG886_RS04060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EG886_RS04065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EG886_RS04070	COG0457	Tetratricopeptide repeat
EG886_RS04070	COG0463	Glycosyl transferase, family 2
EG886_RS04080	COG1120	ATPase activity
EG886_RS04085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EG886_RS04090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EG886_RS04095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EG886_RS04110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EG886_RS04115	COG1971	Probably functions as a manganese efflux pump
EG886_RS04120	COG0237	dephospho-CoA kinase activity
EG886_RS04125	COG0741	lytic transglycosylase activity
EG886_RS04130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EG886_RS04140	COG0697	spore germination
EG886_RS04145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EG886_RS04170	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EG886_RS04175	COG1988	membrane-bound metal-dependent
EG886_RS04185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EG886_RS04190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EG886_RS04195	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EG886_RS04200	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EG886_RS04205	COG0477	Major facilitator Superfamily
EG886_RS04220	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EG886_RS04235	COG0569	domain protein
EG886_RS04240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EG886_RS04245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EG886_RS04250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EG886_RS04250	COG0072	phenylalanine-tRNA ligase activity
EG886_RS04255	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EG886_RS04265	COG1796	DNA polymerase
EG886_RS04265	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EG886_RS04275	COG1193	negative regulation of DNA recombination
EG886_RS04295	COG1929	Belongs to the glycerate kinase type-1 family
EG886_RS04300	COG4129	membrane
EG886_RS04310	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG886_RS04315	COG0183	Belongs to the thiolase family
EG886_RS04320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EG886_RS04355	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EG886_RS04355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EG886_RS04365	COG2081	HI0933 family
EG886_RS04370	COG0318	PFAM AMP-dependent synthetase and ligase
EG886_RS04375	COG1309	transcriptional regulator
EG886_RS04380	COG2086	electron transfer activity
EG886_RS04385	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EG886_RS04390	COG3118	belongs to the thioredoxin family
EG886_RS04400	COG0322	excinuclease ABC activity
EG886_RS04420	COG1525	nuclease
EG886_RS04445	COG0601	transmembrane transport
EG886_RS04450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EG886_RS04455	COG0444	Belongs to the ABC transporter superfamily
EG886_RS04460	COG2009	succinate dehydrogenase
EG886_RS04465	COG1053	succinate dehydrogenase
EG886_RS04470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EG886_RS04475	COG4086	secreted protein
EG886_RS04490	COG1733	regulation of RNA biosynthetic process
EG886_RS04510	COG2197	response regulator
EG886_RS04540	COG0740	serine-type endopeptidase activity
EG886_RS04545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EG886_RS04550	COG2423	ornithine cyclodeaminase activity
EG886_RS04555	COG4264	IucA IucC family
EG886_RS04560	COG2814	Major facilitator Superfamily
EG886_RS04565	COG4264	IucA IucC family
EG886_RS04580	COG0019	diaminopimelate decarboxylase activity
EG886_RS04585	COG1475	DNA binding
EG886_RS04600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EG886_RS04605	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EG886_RS04610	COG2132	Multicopper oxidase
EG886_RS04620	COG0745	RESPONSE REGULATOR receiver
EG886_RS04625	COG5002	protein histidine kinase activity
EG886_RS04630	COG0739	heme binding
EG886_RS04640	COG0210	DNA helicase
EG886_RS04645	COG1032	radical SAM domain protein
EG886_RS04655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EG886_RS04660	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EG886_RS04665	COG1846	Transcriptional regulator
EG886_RS04670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EG886_RS04680	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EG886_RS04685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EG886_RS04690	COG0622	Phosphoesterase
EG886_RS04700	COG0544	peptidyl-prolyl cis-trans isomerase activity
EG886_RS04705	COG0740	serine-type endopeptidase activity
EG886_RS04710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EG886_RS04720	COG0470	DNA polymerase III
EG886_RS04720	COG1067	ATP-dependent peptidase activity
EG886_RS04730	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EG886_RS04735	COG1181	Belongs to the D-alanine--D-alanine ligase family
EG886_RS04750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EG886_RS04770	COG0318	PFAM AMP-dependent synthetase and ligase
EG886_RS04775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EG886_RS04780	COG1116	anion transmembrane transporter activity
EG886_RS04785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EG886_RS04790	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EG886_RS04795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EG886_RS04805	COG0181	hydroxymethylbilane synthase activity
EG886_RS04815	COG0113	porphobilinogen synthase activity
EG886_RS04820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EG886_RS04825	COG1388	LysM domain
EG886_RS04840	COG0285	dihydrofolate synthase activity
EG886_RS04845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EG886_RS04850	COG1999	signal sequence binding
EG886_RS04860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EG886_RS04875	COG0424	maF-like protein
EG886_RS04880	COG2003	Belongs to the UPF0758 family
EG886_RS04885	COG1077	Cell shape determining protein MreB Mrl
EG886_RS04900	COG0850	regulation of cytokinetic process
EG886_RS04905	COG2894	cell division
EG886_RS04915	COG1994	Peptidase M50
EG886_RS04920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EG886_RS04925	COG2868	ribosomal protein
EG886_RS04930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EG886_RS04940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EG886_RS04955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EG886_RS04960	COG4492	Belongs to the UPF0735 family
EG886_RS04965	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EG886_RS04970	COG0083	homoserine kinase activity
EG886_RS04985	COG1131	(ABC) transporter
EG886_RS05015	COG0217	transcriptional regulatory protein
EG886_RS05020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EG886_RS05030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EG886_RS05035	COG1321	iron dependent repressor
EG886_RS05035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EG886_RS05040	COG1121	(ABC) transporter
EG886_RS05045	COG0803	Belongs to the bacterial solute-binding protein 9 family
EG886_RS05070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EG886_RS05075	COG2076	Multidrug Resistance protein
EG886_RS05080	COG2076	Multidrug Resistance protein
EG886_RS05085	COG0697	spore germination
EG886_RS05090	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EG886_RS05095	COG0632	four-way junction helicase activity
EG886_RS05100	COG2255	four-way junction helicase activity
EG886_RS05110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EG886_RS05115	COG0343	queuine tRNA-ribosyltransferase activity
EG886_RS05120	COG1862	Preprotein translocase
EG886_RS05130	COG2323	membrane
EG886_RS05135	COG2244	polysaccharide biosynthetic process
EG886_RS05150	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EG886_RS05155	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EG886_RS05155	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EG886_RS05160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EG886_RS05180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EG886_RS05185	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EG886_RS05195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EG886_RS05200	COG1217	gtp-binding protein TYPA
EG886_RS05205	COG0531	amino acid
EG886_RS05210	COG0583	DNA-binding transcription factor activity
EG886_RS05215	COG1132	(ABC) transporter
EG886_RS05220	COG1132	(ABC) transporter
EG886_RS05225	COG1725	Transcriptional regulator
EG886_RS05235	COG1131	(ABC) transporter
EG886_RS05245	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EG886_RS05250	COG1131	(ABC) transporter
EG886_RS05255	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EG886_RS05265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EG886_RS05270	COG0488	(ABC) transporter
EG886_RS05275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EG886_RS05280	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EG886_RS05290	COG0765	amino acid transport
EG886_RS05295	COG1126	abc transporter atp-binding protein
EG886_RS05315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EG886_RS05320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EG886_RS05325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EG886_RS05330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EG886_RS05335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EG886_RS05340	COG0586	Pfam SNARE associated Golgi protein
EG886_RS05345	COG1279	arginine transmembrane transporter activity
EG886_RS05365	COG1028	Short-chain dehydrogenase reductase Sdr
EG886_RS05370	COG3711	transcriptional antiterminator
EG886_RS05375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EG886_RS05375	COG1263	PTS System
EG886_RS05375	COG2190	(PTS) system
EG886_RS05385	COG1472	Belongs to the glycosyl hydrolase 3 family
EG886_RS05390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EG886_RS05405	COG1515	deoxyribonuclease V activity
EG886_RS05410	COG1401	restriction endodeoxyribonuclease activity
EG886_RS05420	COG0095	Lipoate-protein ligase
EG886_RS05425	COG4221	oxidoreductase activity
EG886_RS05450	COG3599	regulation of cell shape
EG886_RS05455	COG2986	histidine ammonia-lyase
EG886_RS05465	COG1321	iron dependent repressor
EG886_RS05470	COG1752	Esterase of the alpha-beta hydrolase superfamily
EG886_RS05480	COG3872	metal-dependent enzyme
EG886_RS05490	COG0006	proline dipeptidase activity
EG886_RS05495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EG886_RS05500	COG2707	UPF0756 membrane protein
EG886_RS05505	COG1809	phosphosulfolactate synthase activity
EG886_RS05510	COG2814	Major facilitator Superfamily
EG886_RS05520	COG3854	ATPases associated with a variety of cellular activities
EG886_RS05560	COG0511	ligase activity, forming carbon-carbon bonds
EG886_RS05565	COG0439	Biotin carboxylase
EG886_RS05570	COG1302	Protein conserved in bacteria
EG886_RS05575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EG886_RS05580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EG886_RS05590	COG1722	exodeoxyribonuclease VII activity
EG886_RS05595	COG0142	geranyltranstransferase activity
EG886_RS05605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EG886_RS05610	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EG886_RS05620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EG886_RS05625	COG1438	arginine binding
EG886_RS05630	COG0497	DNA recombination
EG886_RS05635	COG0750	zinc metalloprotease
EG886_RS05640	COG0640	Transcriptional regulator
EG886_RS05645	COG0745	RESPONSE REGULATOR receiver
EG886_RS05650	COG0475	glutathione-regulated potassium exporter activity
EG886_RS05665	COG3829	transcription factor binding
EG886_RS05665	COG3290	protein histidine kinase activity
EG886_RS05670	COG0280	phosphate acetyltransferase
EG886_RS05685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EG886_RS05690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EG886_RS05695	COG0022	dehydrogenase e1 component
EG886_RS05700	COG0508	dehydrogenase complex catalyzes the overall conversion of
EG886_RS05705	COG0321	lipoyl(octanoyl) transferase activity
EG886_RS05730	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG886_RS05730	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG886_RS05735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG886_RS05735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG886_RS05740	COG0346	lactoylglutathione lyase activity
EG886_RS05745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EG886_RS05750	COG2195	Cleaves the N-terminal amino acid of tripeptides
EG886_RS05780	COG1379	DNA repair
EG886_RS05785	COG1228	amidohydrolase
EG886_RS05790	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EG886_RS05795	COG0010	Belongs to the arginase family
EG886_RS05800	COG2207	Transcriptional regulator
EG886_RS05850	COG1131	(ABC) transporter
EG886_RS05860	COG3103	Sh3 type 3 domain protein
EG886_RS05860	COG0366	Alpha amylase catalytic
EG886_RS05865	COG1300	Membrane
EG886_RS05870	COG0735	belongs to the Fur family
EG886_RS05875	COG0686	Belongs to the AlaDH PNT family
EG886_RS05885	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EG886_RS05895	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EG886_RS05910	COG1686	Belongs to the peptidase S11 family
EG886_RS05915	COG1366	Belongs to the anti-sigma-factor antagonist family
EG886_RS05920	COG2172	sigma factor antagonist activity
EG886_RS05950	COG0019	diaminopimelate decarboxylase activity
EG886_RS05955	COG1612	heme a metabolic process
EG886_RS05960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EG886_RS05960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EG886_RS05970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EG886_RS05970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EG886_RS05975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EG886_RS05980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EG886_RS05985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EG886_RS05990	COG2032	superoxide dismutase activity
EG886_RS06000	COG3874	Sporulation protein YtfJ
EG886_RS06005	COG1686	Belongs to the peptidase S11 family
EG886_RS06010	COG2715	membrane protein required for spore maturation
EG886_RS06015	COG0700	Nucleoside recognition
EG886_RS06020	COG1309	transcriptional regulator
EG886_RS06030	COG1187	pseudouridine synthase activity
EG886_RS06035	COG1333	cytochrome c biogenesis protein
EG886_RS06040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EG886_RS06045	COG0745	RESPONSE REGULATOR receiver
EG886_RS06050	COG5002	protein histidine kinase activity
EG886_RS06055	COG0318	PFAM AMP-dependent synthetase and ligase
EG886_RS06060	COG4221	oxidoreductase activity
EG886_RS06065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EG886_RS06075	COG0210	DNA helicase
EG886_RS06110	COG4862	establishment of competence for transformation
EG886_RS06115	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EG886_RS06120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EG886_RS06125	COG0492	ferredoxin-NADP+ reductase activity
EG886_RS06140	COG2959	enzyme of heme biosynthesis
EG886_RS06145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EG886_RS06150	COG0204	Acyl-transferase
EG886_RS06150	COG0318	PFAM AMP-dependent synthetase and ligase
EG886_RS06165	COG1160	GTP binding
EG886_RS06170	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EG886_RS06175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EG886_RS06190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EG886_RS06200	COG0302	gtp cyclohydrolase
EG886_RS06220	COG0142	geranyltranstransferase activity
EG886_RS06225	COG2226	methyltransferase
EG886_RS06230	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EG886_RS06235	COG0163	prenyltransferase activity
EG886_RS06240	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EG886_RS06250	COG0105	UTP biosynthetic process
EG886_RS06255	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EG886_RS06260	COG1131	(ABC) transporter
EG886_RS06285	COG1396	sequence-specific DNA binding
EG886_RS06290	COG2274	protein secretion by the type I secretion system
EG886_RS06320	COG4566	intracellular signal transduction
EG886_RS06330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EG886_RS06335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EG886_RS06340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EG886_RS06345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EG886_RS06350	COG0134	indole-3-glycerol-phosphate synthase activity
EG886_RS06355	COG0135	phosphoribosylanthranilate isomerase activity
EG886_RS06360	COG0133	tryptophan synthase activity
EG886_RS06365	COG0159	tryptophan synthase activity
EG886_RS06370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EG886_RS06375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EG886_RS06400	COG0723	plastoquinol--plastocyanin reductase activity
EG886_RS06415	COG4347	Protein of unknown function (DUF1405)
EG886_RS06425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EG886_RS06430	COG1694	Mazg nucleotide pyrophosphohydrolase
EG886_RS06435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EG886_RS06440	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EG886_RS06445	COG1803	Methylglyoxal synthase
EG886_RS06455	COG0438	transferase activity, transferring glycosyl groups
EG886_RS06460	COG0617	tRNA 3'-terminal CCA addition
EG886_RS06500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EG886_RS06505	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EG886_RS06515	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EG886_RS06550	COG1187	pseudouridine synthase activity
EG886_RS06565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EG886_RS06570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EG886_RS06580	COG1793	dna ligase
EG886_RS06590	COG1793	dna ligase
EG886_RS06590	COG3285	dna ligase
EG886_RS06595	COG0402	S-adenosylhomocysteine deaminase activity
EG886_RS06610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EG886_RS06615	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG886_RS06620	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EG886_RS06635	COG4974	Belongs to the 'phage' integrase family
EG886_RS06640	COG2814	Major facilitator Superfamily
EG886_RS06645	COG0702	epimerase
EG886_RS06650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EG886_RS06655	COG4974	Belongs to the 'phage' integrase family
EG886_RS06660	COG1054	Belongs to the UPF0176 family
EG886_RS06665	COG0697	spore germination
EG886_RS06700	COG0789	Transcriptional regulator
EG886_RS06780	COG0655	NAD(P)H dehydrogenase (quinone) activity
EG886_RS06790	COG0714	Associated with various cellular activities
EG886_RS06810	COG1363	Peptidase, m42
EG886_RS06815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EG886_RS06825	COG0697	spore germination
EG886_RS06875	COG0613	PHP domain protein
EG886_RS06880	COG0431	NADPH-dependent FMN reductase
EG886_RS06885	COG0697	spore germination
EG886_RS06890	COG1185	polyribonucleotide nucleotidyltransferase activity
EG886_RS06900	COG0395	ABC-type sugar transport system, permease component
EG886_RS06905	COG1175	transmembrane transport
EG886_RS06925	COG4641	Protein conserved in bacteria
EG886_RS06930	COG3119	arylsulfatase activity
EG886_RS06940	COG0529	Catalyzes the synthesis of activated sulfate
EG886_RS06945	COG4641	Protein conserved in bacteria
EG886_RS06960	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EG886_RS06965	COG1091	dTDP-4-dehydrorhamnose reductase activity
EG886_RS06975	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EG886_RS06985	COG3336	cytochrome c oxidase
EG886_RS06990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EG886_RS07005	COG1979	alcohol dehydrogenase
EG886_RS07010	COG2323	membrane
EG886_RS07015	COG0438	transferase activity, transferring glycosyl groups
EG886_RS07020	COG3935	DnaD domain protein
EG886_RS07025	COG0017	Asparaginyl-tRNA synthetase
EG886_RS07030	COG2843	Capsule synthesis protein
EG886_RS07045	COG1247	-acetyltransferase
EG886_RS07050	COG0174	glutamine synthetase
EG886_RS07055	COG0789	Transcriptional regulator
EG886_RS07065	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EG886_RS07070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EG886_RS07075	COG0464	growth
EG886_RS07080	COG1923	regulation of RNA biosynthetic process
EG886_RS07085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EG886_RS07090	COG2521	methyltransferase
EG886_RS07090	COG2136	Putative SAM-dependent methyltransferase
EG886_RS07095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EG886_RS07100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EG886_RS07110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EG886_RS07125	COG4550	Control of competence regulator ComK, YlbF/YmcA
EG886_RS07130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EG886_RS07135	COG0697	spore germination
EG886_RS07155	COG0156	8-amino-7-oxononanoate synthase activity
EG886_RS07160	COG1063	alcohol dehydrogenase
EG886_RS07165	COG0436	Aminotransferase
EG886_RS07170	COG1234	tRNA 3'-trailer cleavage
EG886_RS07175	COG1013	pyruvate-flavodoxin oxidoreductase activity
EG886_RS07180	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EG886_RS07180	COG0674	pyruvate-flavodoxin oxidoreductase activity
EG886_RS07190	COG2359	stage V sporulation protein S
EG886_RS07195	COG1692	metallophosphoesterase
EG886_RS07200	COG1418	mRNA catabolic process
EG886_RS07215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EG886_RS07225	COG2137	regulation of response to DNA damage stimulus
EG886_RS07230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EG886_RS07235	COG2151	metal-sulfur cluster biosynthetic enzyme
EG886_RS07240	COG0513	Belongs to the DEAD box helicase family
EG886_RS07245	COG1058	Belongs to the CinA family
EG886_RS07245	COG1546	Belongs to the CinA family
EG886_RS07250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EG886_RS07260	COG1426	Protein conserved in bacteria
EG886_RS07265	COG1426	Protein conserved in bacteria
EG886_RS07285	COG0300	oxidoreductase activity
EG886_RS07290	COG0612	Peptidase, M16
EG886_RS07295	COG0612	Peptidase, M16
EG886_RS07300	COG1079	Belongs to the binding-protein-dependent transport system permease family
EG886_RS07305	COG4603	Belongs to the binding-protein-dependent transport system permease family
EG886_RS07310	COG3845	ABC transporter
EG886_RS07315	COG1744	ABC transporter substrate-binding protein PnrA-like
EG886_RS07320	COG1674	ftsk spoiiie
EG886_RS07330	COG0740	serine-type endopeptidase activity
EG886_RS07335	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EG886_RS07340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EG886_RS07345	COG0527	aspartate kinase activity
EG886_RS07350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EG886_RS07355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EG886_RS07360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EG886_RS07375	COG0756	dUTP diphosphatase activity
EG886_RS07380	COG0612	Peptidase, M16
EG886_RS07385	COG0726	polysaccharide deacetylase
EG886_RS07390	COG1185	polyribonucleotide nucleotidyltransferase activity
EG886_RS07395	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EG886_RS07400	COG0196	riboflavin kinase activity
EG886_RS07405	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EG886_RS07410	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EG886_RS07415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EG886_RS07425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EG886_RS07430	COG1358	cellular component organization or biogenesis
EG886_RS07435	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EG886_RS07440	COG0195	Participates in both transcription termination and antitermination
EG886_RS07445	COG0779	Required for maturation of 30S ribosomal subunits
EG886_RS07450	COG1164	Oligoendopeptidase f
EG886_RS07455	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG886_RS07485	COG0442	prolyl-tRNA aminoacylation
EG886_RS07490	COG0750	zinc metalloprotease
EG886_RS07500	COG4589	Belongs to the CDS family
EG886_RS07505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EG886_RS07510	COG0233	cytoplasmic translational termination
EG886_RS07520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EG886_RS07525	COG0052	Belongs to the universal ribosomal protein uS2 family
EG886_RS07530	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EG886_RS07535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EG886_RS07540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EG886_RS07545	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EG886_RS07550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EG886_RS07555	COG0758	DNA mediated transformation
EG886_RS07560	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EG886_RS07565	COG0045	succinate-CoA ligase (ADP-forming) activity
EG886_RS07585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EG886_RS07595	COG2340	Cysteine-rich secretory protein family
EG886_RS07605	COG1028	Short-chain dehydrogenase reductase Sdr
EG886_RS07610	COG2860	membrane
EG886_RS07620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EG886_RS07625	COG1012	belongs to the aldehyde dehydrogenase family
EG886_RS07650	COG0604	alcohol dehydrogenase
EG886_RS07655	COG1408	metallophosphoesterase
EG886_RS07660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EG886_RS07670	COG2329	Antibiotic biosynthesis monooxygenase
EG886_RS07680	COG0606	chelatase, subunit chli
EG886_RS07700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EG886_RS07705	COG0306	phosphate transporter
EG886_RS07715	COG0523	cobalamin synthesis protein
EG886_RS07735	COG0640	Transcriptional regulator
EG886_RS07740	COG0606	chelatase, subunit chli
EG886_RS07745	COG3708	Transcriptional regulator
EG886_RS07745	COG2207	Transcriptional regulator
EG886_RS07780	COG1129	ABC transporter
EG886_RS07790	COG1492	cobalamin metabolic process
EG886_RS07795	COG1797	cobyrinic acid a,c-diamide synthase activity
EG886_RS07805	COG3973	AAA domain
EG886_RS07820	COG0792	nuclease activity
EG886_RS07825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EG886_RS07830	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EG886_RS07840	COG0335	large ribosomal subunit rRNA binding
EG886_RS07845	COG0336	Belongs to the RNA methyltransferase TrmD family
EG886_RS07850	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EG886_RS07865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EG886_RS07870	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EG886_RS07875	COG0552	protein localization to endoplasmic reticulum
EG886_RS07880	COG1196	nuclear chromosome segregation
EG886_RS07885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EG886_RS07895	COG2814	Major facilitator Superfamily
EG886_RS07900	COG0745	RESPONSE REGULATOR receiver
EG886_RS07905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EG886_RS07915	COG0571	ribonuclease III activity
EG886_RS07920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EG886_RS07925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EG886_RS07930	COG1028	Short-chain dehydrogenase reductase Sdr
EG886_RS07935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EG886_RS07945	COG0416	fatty acid biosynthetic process
EG886_RS07950	COG1349	DNA-binding transcription factor activity
EG886_RS07955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EG886_RS07965	COG3480	Lon protease (S16) C-terminal proteolytic domain
EG886_RS07970	COG1752	Esterase of the alpha-beta hydrolase superfamily
EG886_RS07975	COG3314	Sporulation integral membrane protein YlbJ
EG886_RS07980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EG886_RS07985	COG0742	ribosomal rna small subunit methyltransferase
EG886_RS08000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EG886_RS08005	COG1760	l-serine dehydratase
EG886_RS08010	COG1760	l-serine dehydratase
EG886_RS08015	COG1307	EDD domain protein, DegV family
EG886_RS08020	COG1461	Dihydroxyacetone kinase
EG886_RS08025	COG1302	Protein conserved in bacteria
EG886_RS08030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EG886_RS08040	COG1564	THIamine pyrophosphokinase
EG886_RS08050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EG886_RS08055	COG1162	GTPase activity
EG886_RS08060	COG2815	serine threonine protein kinase
EG886_RS08060	COG0515	serine threonine protein kinase
EG886_RS08065	COG0631	protein serine/threonine phosphatase activity
EG886_RS08070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EG886_RS08080	COG0814	amino acid
EG886_RS08085	COG0697	spore germination
EG886_RS08090	COG1741	Belongs to the pirin family
EG886_RS08095	COG2259	Doxx family
EG886_RS08100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EG886_RS08100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EG886_RS08105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EG886_RS08110	COG0242	peptide deformylase activity
EG886_RS08115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EG886_RS08120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EG886_RS08125	COG1758	RNA polymerase activity
EG886_RS08130	COG0194	GDP metabolic process
EG886_RS08135	COG2052	Domain of unknown function (DUF370)
EG886_RS08140	COG1561	YicC-like family, N-terminal region
EG886_RS08145	COG2244	polysaccharide biosynthetic process
EG886_RS08150	COG0531	amino acid
EG886_RS08155	COG1363	Peptidase, m42
EG886_RS08160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EG886_RS08165	COG0166	Belongs to the GPI family
EG886_RS08175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EG886_RS08180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EG886_RS08185	COG1293	RNA-binding protein homologous to eukaryotic snRNP
EG886_RS08200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EG886_RS08205	COG0284	orotidine-5'-phosphate decarboxylase activity
EG886_RS08210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EG886_RS08220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EG886_RS08225	COG0540	Belongs to the ATCase OTCase family
EG886_RS08230	COG2233	PERMEase
EG886_RS08240	COG0564	pseudouridine synthase activity
EG886_RS08245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EG886_RS08250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EG886_RS08255	COG1113	amino acid transport
EG886_RS08260	COG0588	phosphoglycerate mutase activity
EG886_RS08265	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EG886_RS08270	COG3599	regulation of cell shape
EG886_RS08275	COG2302	S4 RNA-binding domain
EG886_RS08280	COG0762	integral membrane protein
EG886_RS08285	COG1799	cell septum assembly
EG886_RS08290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EG886_RS08300	COG1873	PFAM PRC-barrel domain
EG886_RS08305	COG1191	sigma factor activity
EG886_RS08310	COG1191	sigma factor activity
EG886_RS08320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EG886_RS08325	COG0849	cell division
EG886_RS08335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EG886_RS08340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EG886_RS08345	COG0772	Belongs to the SEDS family
EG886_RS08350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EG886_RS08355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EG886_RS08360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EG886_RS08370	COG0768	penicillin binding
EG886_RS08375	COG0768	penicillin binding
EG886_RS08385	COG0275	rRNA processing
EG886_RS08390	COG2001	Belongs to the MraZ family
EG886_RS08395	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EG886_RS08400	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EG886_RS08405	COG2814	Major facilitator Superfamily
EG886_RS08410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EG886_RS08415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EG886_RS08420	COG1024	Enoyl-CoA hydratase
EG886_RS08425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EG886_RS08430	COG0511	ligase activity, forming carbon-carbon bonds
EG886_RS08435	COG0439	Biotin carboxylase
EG886_RS08455	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EG886_RS08465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EG886_RS08470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EG886_RS08475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG886_RS08480	COG0785	Cytochrome C biogenesis protein
EG886_RS08485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG886_RS08490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG886_RS08510	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EG886_RS08515	COG0584	glycerophosphoryl diester phosphodiesterase
EG886_RS08525	COG4493	Belongs to the UPF0637 family
EG886_RS08530	COG1982	Orn Lys Arg decarboxylase major
EG886_RS08565	COG0671	phosphoesterase, PA-phosphatase related
EG886_RS08580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EG886_RS08615	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EG886_RS08620	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EG886_RS08630	COG0613	PHP domain protein
EG886_RS08635	COG0653	protein targeting
EG886_RS08640	COG3584	3D domain protein
EG886_RS08640	COG3583	domain protein
EG886_RS08645	COG2720	vancomycin resistance protein
EG886_RS08650	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EG886_RS08655	COG2155	Conserved Protein
EG886_RS08660	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EG886_RS08670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EG886_RS08695	COG4537	Required for transformation and DNA binding
EG886_RS08700	COG1459	type II secretion system
EG886_RS08715	COG0861	Integral membrane protein TerC family
EG886_RS08720	COG4187	Peptidase family M20/M25/M40
EG886_RS08725	COG0301	tRNA thio-modification
EG886_RS08730	COG1104	cysteine desulfurase activity
EG886_RS08735	COG1609	Transcriptional regulator
EG886_RS08750	COG3833	ABC-type maltose transport systems, permease component
EG886_RS08755	COG1175	transmembrane transport
EG886_RS08760	COG2182	Extracellular solute-binding protein
EG886_RS08775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EG886_RS08780	COG0288	reversible hydration of carbon dioxide
EG886_RS08805	COG4166	transmembrane transport
EG886_RS08820	COG3599	regulation of cell shape
EG886_RS08830	COG2738	Putative neutral zinc metallopeptidase
EG886_RS08835	COG0475	glutathione-regulated potassium exporter activity
EG886_RS08840	COG0772	Belongs to the SEDS family
EG886_RS08845	COG0772	Belongs to the SEDS family
EG886_RS08850	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EG886_RS08850	COG0456	acetyltransferase
EG886_RS08860	COG0586	Pfam SNARE associated Golgi protein
EG886_RS08870	COG1363	Peptidase, m42
EG886_RS08890	COG1309	transcriptional regulator
EG886_RS08895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EG886_RS08900	COG2384	SAM-dependent methyltransferase
EG886_RS08910	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EG886_RS08920	COG0318	PFAM AMP-dependent synthetase and ligase
EG886_RS08925	COG1960	acyl-CoA dehydrogenase activity
EG886_RS08935	COG0358	DNA primase activity
EG886_RS08940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EG886_RS08940	COG0574	Belongs to the PEP-utilizing enzyme family
EG886_RS08945	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EG886_RS08950	COG0517	IMP dehydrogenase activity
EG886_RS08965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EG886_RS08970	COG0751	glycine-tRNA ligase activity
EG886_RS08975	COG0752	glycyl-tRNA synthetase alpha subunit
EG886_RS08980	COG1381	Involved in DNA repair and RecF pathway recombination
EG886_RS08990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EG886_RS08995	COG0295	cytidine deaminase activity
EG886_RS09000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EG886_RS09005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EG886_RS09010	COG1480	7TM receptor with intracellular HD hydrolase
EG886_RS09015	COG1702	phosphate starvation-inducible protein PhoH
EG886_RS09040	COG4864	UPF0365 protein
EG886_RS09045	COG1030	water channel activity
EG886_RS09050	COG1610	YqeY-like protein
EG886_RS09055	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EG886_RS09060	COG0537	adenosine 5'-monophosphoramidase activity
EG886_RS09080	COG1283	sodium-dependent phosphate transmembrane transporter activity
EG886_RS09085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EG886_RS09090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EG886_RS09095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EG886_RS09100	COG2264	protein methyltransferase activity
EG886_RS09110	COG0443	Heat shock 70 kDa protein
EG886_RS09120	COG0459	protein refolding
EG886_RS09125	COG1420	regulation of RNA biosynthetic process
EG886_RS09130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EG886_RS09135	COG0481	GTPase activity
EG886_RS09145	COG0860	N-Acetylmuramoyl-L-alanine amidase
EG886_RS09155	COG0268	Binds directly to 16S ribosomal RNA
EG886_RS09165	COG2814	Major facilitator Superfamily
EG886_RS09170	COG0180	Tryptophanyl-tRNA synthetase
EG886_RS09175	COG4846	Membrane protein involved in cytochrome C biogenesis
EG886_RS09180	COG1683	Conserved Protein
EG886_RS09195	COG1466	dna polymerase III delta subunit
EG886_RS09205	COG1595	DNA-templated transcription, initiation
EG886_RS09210	COG2333	competence protein COMEC
EG886_RS09210	COG0658	competence protein
EG886_RS09215	COG0717	Belongs to the dCTP deaminase family
EG886_RS09220	COG0626	cystathionine gamma-synthase activity
EG886_RS09225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EG886_RS09230	COG1596	polysaccharide export
EG886_RS09230	COG1555	photosystem II stabilization
EG886_RS09235	COG2046	Belongs to the sulfate adenylyltransferase family
EG886_RS09240	COG0175	sulfate reduction
EG886_RS09245	COG0495	leucyl-tRNA aminoacylation
EG886_RS09250	COG0799	negative regulation of ribosome biogenesis
EG886_RS09255	COG1713	HD superfamily hydrolase involved in NAD metabolism
EG886_RS09260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EG886_RS09265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EG886_RS09270	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EG886_RS09275	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EG886_RS09290	COG0006	proline dipeptidase activity
EG886_RS09295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EG886_RS09300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EG886_RS09300	COG1017	nitric oxide dioxygenase activity
EG886_RS09305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EG886_RS09315	COG0235	Class ii aldolase
EG886_RS09320	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EG886_RS09325	COG1850	ribulose-bisphosphate carboxylase activity
EG886_RS09330	COG0436	Aminotransferase
EG886_RS09335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EG886_RS09340	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EG886_RS09345	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EG886_RS09355	COG1309	transcriptional regulator
EG886_RS09360	COG2271	Major facilitator Superfamily
EG886_RS09370	COG0084	hydrolase, TatD family'
EG886_RS09375	COG0656	L-ascorbic acid biosynthetic process
EG886_RS09380	COG1132	(ABC) transporter
EG886_RS09390	COG2211	Major facilitator Superfamily
EG886_RS09410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EG886_RS09415	COG1733	regulation of RNA biosynthetic process
EG886_RS09420	COG1902	pentaerythritol trinitrate reductase activity
EG886_RS09440	COG0386	Belongs to the glutathione peroxidase family
EG886_RS09445	COG0596	Alpha beta hydrolase
EG886_RS09460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EG886_RS09470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EG886_RS09495	COG4948	Mandelate Racemase Muconate Lactonizing
EG886_RS09505	COG1473	amidohydrolase
EG886_RS09520	COG0346	lactoylglutathione lyase activity
EG886_RS09530	COG1960	acyl-CoA dehydrogenase activity
EG886_RS09550	COG2226	methyltransferase
EG886_RS09550	COG3433	isochorismatase activity
EG886_RS09550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EG886_RS09560	COG1304	FMN binding
EG886_RS09600	COG1051	belongs to the nudix hydrolase family
EG886_RS09620	COG0768	penicillin binding
EG886_RS09630	COG3906	Belongs to the UPF0473 family
EG886_RS09635	COG3906	Belongs to the UPF0473 family
EG886_RS09645	COG4472	Bacterial protein of unknown function (DUF965)
EG886_RS09650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EG886_RS09660	COG0628	permease
EG886_RS09680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EG886_RS09690	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EG886_RS09700	COG1104	cysteine desulfurase activity
EG886_RS09705	COG1959	2 iron, 2 sulfur cluster binding
EG886_RS09720	COG5577	PFAM Coat F domain
EG886_RS09735	COG0456	acetyltransferase
EG886_RS09735	COG1846	Transcriptional regulator
EG886_RS09740	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EG886_RS09750	COG2363	Small membrane protein
EG886_RS09760	COG1490	D-aminoacyl-tRNA deacylase activity
EG886_RS09765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EG886_RS09775	COG1074	ATP-dependent DNA helicase activity
EG886_RS09780	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EG886_RS09790	COG4717	serine-type aminopeptidase activity
EG886_RS09800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EG886_RS09805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EG886_RS09810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EG886_RS09820	COG0154	amidase activity
EG886_RS09825	COG1082	Xylose isomerase domain protein TIM barrel
EG886_RS09835	COG1012	belongs to the aldehyde dehydrogenase family
EG886_RS09840	COG0346	lactoylglutathione lyase activity
EG886_RS09845	COG0477	Major facilitator Superfamily
EG886_RS09850	COG0688	phosphatidylethanolamine metabolic process
EG886_RS09860	COG0768	penicillin binding
EG886_RS09865	COG1404	Belongs to the peptidase S8 family
EG886_RS09885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EG886_RS09905	COG3546	catalase activity
EG886_RS09910	COG1518	maintenance of DNA repeat elements
EG886_RS09915	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EG886_RS09935	COG2894	cell division
EG886_RS09950	COG4471	UPF0298 protein
EG886_RS09985	COG2239	Acts as a magnesium transporter
EG886_RS09990	COG1253	flavin adenine dinucleotide binding
EG886_RS10005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EG886_RS10020	COG0517	IMP dehydrogenase activity
EG886_RS10025	COG1473	amidohydrolase
EG886_RS10035	COG1302	Protein conserved in bacteria
EG886_RS10045	COG0387	Pfam Sodium calcium exchanger
EG886_RS10055	COG4838	Belongs to the UPF0358 family
EG886_RS10060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EG886_RS10075	COG2050	protein possibly involved in aromatic compounds catabolism
EG886_RS10080	COG1363	Peptidase, m42
EG886_RS10090	COG1956	GAF domain-containing protein
EG886_RS10100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EG886_RS10115	COG1028	Short-chain dehydrogenase reductase Sdr
EG886_RS10120	COG2610	gluconate transmembrane transporter activity
EG886_RS10125	COG3829	transcription factor binding
EG886_RS10125	COG3290	protein histidine kinase activity
EG886_RS10130	COG0671	phosphoesterase, PA-phosphatase related
EG886_RS10135	COG0406	alpha-ribazole phosphatase activity
EG886_RS10155	COG1653	transport
EG886_RS10160	COG0673	inositol 2-dehydrogenase activity
EG886_RS10165	COG0673	inositol 2-dehydrogenase activity
EG886_RS10170	COG1082	Xylose isomerase domain protein TIM barrel
EG886_RS10175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EG886_RS10180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EG886_RS10185	COG0494	nUDIX hydrolase
EG886_RS10195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EG886_RS10200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EG886_RS10205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EG886_RS10205	COG4499	WXG100 protein secretion system (Wss), protein YukC
EG886_RS10210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EG886_RS10220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EG886_RS10225	COG1609	Transcriptional regulator
EG886_RS10235	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EG886_RS10235	COG1605	Chorismate mutase
EG886_RS10245	COG4980	gas vesicle protein
EG886_RS10255	COG0473	3-isopropylmalate dehydrogenase activity
EG886_RS10260	COG2364	Membrane
EG886_RS10295	COG1832	CoA-binding protein
EG886_RS10320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EG886_RS10335	COG1268	BioY protein
EG886_RS10345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EG886_RS10365	COG3773	Cell wall hydrolase
EG886_RS10370	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EG886_RS10375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EG886_RS10385	COG2814	Major facilitator Superfamily
EG886_RS10415	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EG886_RS10420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EG886_RS10425	COG2135	peptidase activity
EG886_RS10430	COG0179	Fumarylacetoacetate (FAA) hydrolase
EG886_RS10460	COG1376	ErfK ybiS ycfS ynhG family protein
EG886_RS10465	COG1376	ErfK ybiS ycfS ynhG family protein
EG886_RS10470	COG3238	Protein conserved in bacteria
EG886_RS10475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EG886_RS10480	COG0157	Belongs to the NadC ModD family
EG886_RS10485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EG886_RS10490	COG1104	cysteine desulfurase activity
EG886_RS10500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EG886_RS10505	COG0306	phosphate transporter
EG886_RS10530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EG886_RS10535	COG0482	sulfurtransferase activity
EG886_RS10630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EG886_RS10655	COG1024	Enoyl-CoA hydratase
EG886_RS10660	COG1024	Enoyl-CoA hydratase
EG886_RS10665	COG2002	toxin-antitoxin pair type II binding
EG886_RS10675	COG1191	sigma factor activity
EG886_RS10680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EG886_RS10715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EG886_RS10725	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EG886_RS10730	COG0602	queuosine metabolic process
EG886_RS10795	COG1414	Transcriptional regulator
EG886_RS10800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EG886_RS10810	COG1994	Peptidase M50
EG886_RS10815	COG0805	protein transport
EG886_RS10830	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EG886_RS10845	COG1547	Domain of unknown function (DUF309)
EG886_RS10850	COG4840	Belongs to the UPF0435 family
EG886_RS10855	COG0824	Thioesterase
EG886_RS10895	COG1242	4 iron, 4 sulfur cluster binding
EG886_RS10900	COG0275	rRNA processing
EG886_RS10905	COG4166	transmembrane transport
EG886_RS10915	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EG886_RS10920	COG0572	uridine kinase
EG886_RS10930	COG0509	glycine decarboxylation via glycine cleavage system
EG886_RS10935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG886_RS10940	COG0450	alkyl hydroperoxide reductase
EG886_RS10950	COG2226	methyltransferase
EG886_RS10955	COG1309	transcriptional regulator
EG886_RS10965	COG1393	Belongs to the ArsC family
EG886_RS10970	COG2096	Adenosyltransferase
EG886_RS10975	COG1120	ATPase activity
EG886_RS10980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EG886_RS10985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EG886_RS11000	COG2217	Heavy metal translocating P-type atpase
EG886_RS11005	COG1937	Protein conserved in bacteria
EG886_RS11020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EG886_RS11025	COG3949	Membrane
EG886_RS11030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EG886_RS11045	COG0564	pseudouridine synthase activity
EG886_RS11060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EG886_RS11065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EG886_RS11065	COG1116	anion transmembrane transporter activity
EG886_RS11070	COG1305	Transglutaminase-like
EG886_RS11075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EG886_RS11090	COG4496	protein, YerC YecD
EG886_RS11095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EG886_RS11105	COG0778	Nitroreductase
EG886_RS11110	COG0586	Pfam SNARE associated Golgi protein
EG886_RS11130	COG1309	transcriptional regulator
EG886_RS11145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EG886_RS11150	COG1597	lipid kinase activity
EG886_RS11155	COG2252	PERMEase
EG886_RS11160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EG886_RS11165	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EG886_RS11175	COG2843	Capsule synthesis protein
EG886_RS11190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EG886_RS11195	COG0154	amidase activity
EG886_RS11205	COG1966	Carbon starvation protein
EG886_RS11220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EG886_RS11225	COG0765	amino acid transport
EG886_RS11230	COG0765	amino acid transport
EG886_RS11240	COG1126	abc transporter atp-binding protein
EG886_RS11250	COG1012	belongs to the aldehyde dehydrogenase family
EG886_RS11255	COG0506	proline dehydrogenase activity
EG886_RS11280	COG0640	Transcriptional regulator
EG886_RS11310	COG1309	transcriptional regulator
EG886_RS11315	COG2226	methyltransferase
EG886_RS11320	COG1960	acyl-CoA dehydrogenase activity
EG886_RS11325	COG0183	Belongs to the thiolase family
EG886_RS11330	COG1024	Enoyl-CoA hydratase
EG886_RS11330	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG886_RS11375	COG3739	integral membrane protein
EG886_RS11380	COG3655	Transcriptional regulator
EG886_RS11425	COG1337	RAMP superfamily
EG886_RS11465	COG1960	acyl-CoA dehydrogenase activity
EG886_RS11495	COG2205	protein histidine kinase activity
EG886_RS11500	COG0745	RESPONSE REGULATOR receiver
EG886_RS11505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EG886_RS11550	COG0860	N-Acetylmuramoyl-L-alanine amidase
EG886_RS11550	COG2247	cell wall binding repeat
EG886_RS11560	COG4326	sporulation control protein
EG886_RS11585	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EG886_RS11590	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EG886_RS11590	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EG886_RS11590	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EG886_RS11590	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EG886_RS11600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EG886_RS11605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EG886_RS11610	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EG886_RS11625	COG1376	ErfK ybiS ycfS ynhG family protein
EG886_RS11645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EG886_RS11660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EG886_RS11660	COG0646	methionine synthase
EG886_RS11665	COG1410	methionine synthase
EG886_RS11665	COG0646	methionine synthase
EG886_RS11685	COG1061	Type III restriction enzyme res subunit
EG886_RS11720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EG886_RS11730	COG1879	ABC-type sugar transport system periplasmic component
EG886_RS11735	COG1172	Belongs to the binding-protein-dependent transport system permease family
EG886_RS11740	COG1129	ABC transporter
EG886_RS11745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EG886_RS11755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EG886_RS11755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EG886_RS11765	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EG886_RS11770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EG886_RS11775	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EG886_RS11780	COG0297	glycogen (starch) synthase activity
EG886_RS11785	COG0438	transferase activity, transferring glycosyl groups
EG886_RS11805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EG886_RS11810	COG1316	TRANSCRIPTIONal
EG886_RS11825	COG1337	RAMP superfamily
EG886_RS11870	COG0326	Molecular chaperone. Has ATPase activity
EG886_RS11875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EG886_RS11890	COG2442	InterPro IPR007367
EG886_RS11905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EG886_RS11910	COG0557	exoribonuclease II activity
EG886_RS11925	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EG886_RS11930	COG0148	phosphopyruvate hydratase activity
EG886_RS11940	COG0149	triose-phosphate isomerase activity
EG886_RS11960	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EG886_RS11970	COG0740	serine-type endopeptidase activity
EG886_RS11975	COG1525	nuclease
EG886_RS11990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EG886_RS11995	COG1481	regulation of sporulation
EG886_RS12000	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EG886_RS12005	COG1660	Displays ATPase and GTPase activities
EG886_RS12010	COG1940	carbohydrate kinase activity
EG886_RS12015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EG886_RS12020	COG0457	Tetratricopeptide repeat
EG886_RS12025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EG886_RS12025	COG0140	phosphoribosyl-ATP diphosphatase activity
EG886_RS12030	COG0107	imidazoleglycerol-phosphate synthase activity
EG886_RS12035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EG886_RS12040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EG886_RS12045	COG0131	Imidazoleglycerol-phosphate dehydratase
EG886_RS12055	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EG886_RS12060	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EG886_RS12065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EG886_RS12075	COG0167	dihydroorotate dehydrogenase activity
EG886_RS12080	COG1923	regulation of RNA biosynthetic process
EG886_RS12095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EG886_RS12105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EG886_RS12120	COG0110	maltose O-acetyltransferase activity
EG886_RS12125	COG0546	phosphoglycolate phosphatase activity
EG886_RS12130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EG886_RS12140	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EG886_RS12145	COG3842	ATPase activity
EG886_RS12150	COG3835	regulator
EG886_RS12155	COG1950	PFAM Membrane protein of
EG886_RS12160	COG3764	Sortase (surface protein transpeptidase)
EG886_RS12165	COG4555	ABC transporter
EG886_RS12195	COG1132	(ABC) transporter
EG886_RS12200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EG886_RS12205	COG0556	nucleotide-excision repair
EG886_RS12215	COG0793	Belongs to the peptidase S41A family
EG886_RS12215	COG3409	Peptidoglycan-binding domain 1 protein
EG886_RS12220	COG0739	heme binding
EG886_RS12225	COG0739	heme binding
EG886_RS12230	COG4942	peptidase
EG886_RS12235	COG2177	Part of the ABC transporter FtsEX involved in
EG886_RS12240	COG2884	Cell division ATP-binding protein ftsE
EG886_RS12245	COG0165	Argininosuccinate lyase
EG886_RS12250	COG0137	argininosuccinate synthase activity
EG886_RS12280	COG0861	Integral membrane protein TerC family
EG886_RS12285	COG2197	response regulator
EG886_RS12350	COG1131	(ABC) transporter
EG886_RS12365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EG886_RS12375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EG886_RS12380	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EG886_RS12385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EG886_RS12400	COG1024	Enoyl-CoA hydratase
EG886_RS12410	COG0653	protein targeting
EG886_RS12440	COG1278	Cold shock
EG886_RS12450	COG0765	amino acid transport
EG886_RS12470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EG886_RS12475	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EG886_RS12485	COG2197	response regulator
EG886_RS12490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EG886_RS12495	COG1404	Belongs to the peptidase S8 family
EG886_RS12500	COG1316	TRANSCRIPTIONal
EG886_RS12505	COG1739	Uncharacterized protein family UPF0029
EG886_RS12515	COG2011	ABC-type metal ion transport system permease component
EG886_RS12520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EG886_RS12525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EG886_RS12540	COG1316	TRANSCRIPTIONal
EG886_RS12550	COG3307	-O-antigen
EG886_RS12585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EG886_RS12590	COG0281	malic enzyme
EG886_RS12595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EG886_RS12605	COG1609	Transcriptional regulator
EG886_RS12610	COG0739	heme binding
EG886_RS12620	COG2385	sporulation resulting in formation of a cellular spore
EG886_RS12625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EG886_RS12640	COG1007	ATP synthesis coupled electron transport
EG886_RS12645	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG886_RS12650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EG886_RS12660	COG0839	Belongs to the complex I subunit 6 family
EG886_RS12665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG886_RS12670	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EG886_RS12675	COG0649	NAD binding
EG886_RS12680	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG886_RS12685	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG886_RS12690	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EG886_RS12695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EG886_RS12700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EG886_RS12705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EG886_RS12710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EG886_RS12715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EG886_RS12720	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EG886_RS12745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EG886_RS12750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EG886_RS12755	COG4475	Protein of unknown function (DUF436)
EG886_RS12760	COG0698	ribose 5-phosphate isomerase
EG886_RS12765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EG886_RS12770	COG1971	Probably functions as a manganese efflux pump
EG886_RS12775	COG0009	L-threonylcarbamoyladenylate synthase
EG886_RS12790	COG2890	protein-(glutamine-N5) methyltransferase activity
EG886_RS12795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EG886_RS12810	COG0456	acetyltransferase
EG886_RS12815	COG1435	thymidine kinase activity
EG886_RS12820	COG0254	rRNA binding
EG886_RS12830	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EG886_RS12835	COG1494	fructose-1,6-bisphosphatase
EG886_RS12840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EG886_RS12845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EG886_RS12850	COG0191	fructose-bisphosphate aldolase activity
EG886_RS12855	COG3246	L-lysine catabolic process to acetate
EG886_RS12860	COG1607	acyl-coa hydrolase
EG886_RS12865	COG2204	response regulator
EG886_RS12870	COG5018	Exonuclease
EG886_RS12895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EG886_RS12900	COG0456	acetyltransferase
EG886_RS12910	COG0504	CTP synthase activity
EG886_RS12915	COG3343	RNA polymerase activity
EG886_RS12920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EG886_RS12925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EG886_RS12930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EG886_RS12935	COG1120	ATPase activity
EG886_RS12950	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG886_RS12950	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG886_RS12950	COG1703	isobutyryl-CoA mutase activity
EG886_RS12955	COG1309	transcriptional regulator
EG886_RS12965	COG1960	acyl-CoA dehydrogenase activity
EG886_RS12970	COG1960	acyl-CoA dehydrogenase activity
EG886_RS12975	COG1250	3-hydroxyacyl-CoA dehydrogenase
EG886_RS12980	COG0183	Belongs to the thiolase family
EG886_RS12985	COG0069	glutamate synthase activity
EG886_RS12995	COG0247	lactate metabolic process
EG886_RS12995	COG2181	nitrate reductase activity
EG886_RS13015	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EG886_RS13020	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EG886_RS13025	COG1193	negative regulation of DNA recombination
EG886_RS13030	COG1509	lysine 2,3-aminomutase activity
EG886_RS13035	COG0604	alcohol dehydrogenase
EG886_RS13040	COG3829	transcription factor binding
EG886_RS13055	COG0018	arginyl-trna synthetase
EG886_RS13065	COG0010	Belongs to the arginase family
EG886_RS13070	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EG886_RS13075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EG886_RS13090	COG4191	Histidine kinase
EG886_RS13105	COG0745	RESPONSE REGULATOR receiver
EG886_RS13110	COG5002	protein histidine kinase activity
EG886_RS13120	COG4853	Protein conserved in bacteria
EG886_RS13125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EG886_RS13135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EG886_RS13145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EG886_RS13150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EG886_RS13155	COG0305	Participates in initiation and elongation during chromosome replication
EG886_RS13160	COG0359	binds to the 23S rRNA
EG886_RS13165	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EG886_RS13175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EG886_RS13180	COG0629	single-stranded DNA binding
EG886_RS13185	COG0360	Binds together with S18 to 16S ribosomal RNA
EG886_RS13190	COG0012	GTP binding
EG886_RS13195	COG4481	Protein conserved in bacteria
EG886_RS13200	COG0204	Acyl-transferase
EG886_RS13215	COG1475	DNA binding
EG886_RS13220	COG1192	Involved in chromosome partitioning
EG886_RS13225	COG1475	DNA binding
EG886_RS13240	COG0357	Ribosomal RNA small subunit methyltransferase G
EG886_RS13245	COG0445	tRNA wobble uridine modification
EG886_RS13250	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EG886_RS13255	COG1847	R3H domain protein
EG886_RS13260	COG0706	membrane insertase activity
EG886_RS13265	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EG886_RS13275	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EG886_RS13285	COG4824	toxin secretion phage lysis holin
EG886_RS13290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EG886_RS13365	COG4626	Terminase
EG886_RS13365	COG1802	Transcriptional regulator
EG886_RS13425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EG886_RS13450	COG0305	Participates in initiation and elongation during chromosome replication
EG886_RS13480	COG1396	sequence-specific DNA binding
EG886_RS13545	COG1403	HNH endonuclease
EG886_RS13570	COG0489	protein tyrosine kinase activity