locus-tag	class	description
THEBR_RS00010	COG0592	DNA-directed DNA polymerase activity
THEBR_RS00015	COG2501	S4 domain
THEBR_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THEBR_RS00035	COG3442	glutamine amidotransferase
THEBR_RS00045	COG0187	DNA topoisomerase II activity
THEBR_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THEBR_RS00055	COG1902	pentaerythritol trinitrate reductase activity
THEBR_RS00060	COG0440	acetolactate synthase activity
THEBR_RS00065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THEBR_RS00070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEBR_RS00075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THEBR_RS00080	COG0066	3-isopropylmalate dehydratase activity
THEBR_RS00085	COG0473	3-isopropylmalate dehydrogenase activity
THEBR_RS00090	COG0129	dihydroxy-acid dehydratase activity
THEBR_RS00095	COG0028	Belongs to the TPP enzyme family
THEBR_RS00110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THEBR_RS00110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THEBR_RS00115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THEBR_RS00120	COG0628	permease
THEBR_RS00155	COG0582	viral genome integration into host DNA
THEBR_RS00170	COG1396	sequence-specific DNA binding
THEBR_RS00210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEBR_RS00210	COG2199	diguanylate cyclase activity
THEBR_RS00255	COG3344	reverse transcriptase
THEBR_RS00315	COG0739	heme binding
THEBR_RS00335	COG4962	Type ii secretion system protein e
THEBR_RS00465	COG0358	DNA primase activity
THEBR_RS00495	COG0582	viral genome integration into host DNA
THEBR_RS00505	COG0658	competence protein
THEBR_RS00505	COG2333	competence protein COMEC
THEBR_RS00515	COG3344	reverse transcriptase
THEBR_RS00520	COG0308	aminopeptidase N
THEBR_RS00525	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THEBR_RS00535	COG0739	heme binding
THEBR_RS00545	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THEBR_RS00550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEBR_RS00555	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THEBR_RS00565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THEBR_RS00575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THEBR_RS00595	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THEBR_RS00600	COG0396	ATPase activity
THEBR_RS00605	COG0719	Fe-S assembly protein
THEBR_RS00615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THEBR_RS00620	COG0822	iron-sulfur transferase activity
THEBR_RS00675	COG3340	Belongs to the peptidase S51 family
THEBR_RS00685	COG1518	maintenance of DNA repeat elements
THEBR_RS00690	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THEBR_RS00700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
THEBR_RS00705	COG3344	reverse transcriptase
THEBR_RS00715	COG0460	homoserine dehydrogenase
THEBR_RS00720	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THEBR_RS00725	COG0083	homoserine kinase activity
THEBR_RS00735	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THEBR_RS00740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THEBR_RS00750	COG0504	CTP synthase activity
THEBR_RS00765	COG3344	reverse transcriptase
THEBR_RS00775	COG1349	DNA-binding transcription factor activity
THEBR_RS00785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEBR_RS00785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEBR_RS00785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEBR_RS00800	COG0071	Belongs to the small heat shock protein (HSP20) family
THEBR_RS00810	COG1609	Transcriptional regulator
THEBR_RS00815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THEBR_RS00820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THEBR_RS00825	COG2088	sporulation resulting in formation of a cellular spore
THEBR_RS00830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THEBR_RS00835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THEBR_RS00840	COG3344	reverse transcriptase
THEBR_RS00845	COG0745	RESPONSE REGULATOR receiver
THEBR_RS00850	COG5002	protein histidine kinase activity
THEBR_RS00855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEBR_RS00860	COG0193	aminoacyl-tRNA hydrolase activity
THEBR_RS00870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THEBR_RS00875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THEBR_RS00880	COG2002	toxin-antitoxin pair type II binding
THEBR_RS00895	COG4466	Protein conserved in bacteria
THEBR_RS00900	COG1388	LysM domain
THEBR_RS00905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THEBR_RS00910	COG1802	Transcriptional regulator
THEBR_RS00925	COG0697	spore germination
THEBR_RS00930	COG0531	amino acid
THEBR_RS00950	COG2959	enzyme of heme biosynthesis
THEBR_RS00970	COG0018	arginyl-trna synthetase
THEBR_RS00975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THEBR_RS00980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THEBR_RS00990	COG1131	(ABC) transporter
THEBR_RS01015	COG4608	Belongs to the ABC transporter superfamily
THEBR_RS01020	COG0444	Belongs to the ABC transporter superfamily
THEBR_RS01030	COG0601	transmembrane transport
THEBR_RS01035	COG0747	negative chemotaxis
THEBR_RS01045	COG0667	Aldo Keto reductase
THEBR_RS01055	COG1454	alcohol dehydrogenase
THEBR_RS01055	COG1012	belongs to the aldehyde dehydrogenase family
THEBR_RS01065	COG1846	Transcriptional regulator
THEBR_RS01075	COG1132	(ABC) transporter
THEBR_RS01080	COG3859	Proton-coupled thiamine transporter YuaJ
THEBR_RS01085	COG0671	phosphoesterase, PA-phosphatase related
THEBR_RS01095	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THEBR_RS01095	COG1796	DNA polymerase
THEBR_RS01100	COG0493	'glutamate synthase
THEBR_RS01100	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
THEBR_RS01140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THEBR_RS01145	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THEBR_RS01150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THEBR_RS01155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THEBR_RS01160	COG0505	Belongs to the CarA family
THEBR_RS01165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THEBR_RS01170	COG0137	argininosuccinate synthase activity
THEBR_RS01180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THEBR_RS01190	COG0588	phosphoglycerate mutase activity
THEBR_RS01195	COG1528	Iron-storage protein
THEBR_RS01235	COG2033	superoxide reductase activity
THEBR_RS01240	COG5002	protein histidine kinase activity
THEBR_RS01245	COG1027	Aspartate ammonia-lyase
THEBR_RS01250	COG1160	GTP binding
THEBR_RS01255	COG2814	Major facilitator Superfamily
THEBR_RS01265	COG3956	TIGRFAM MazG family protein
THEBR_RS01270	COG0776	regulation of translation
THEBR_RS01275	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THEBR_RS01280	COG2385	sporulation resulting in formation of a cellular spore
THEBR_RS01315	COG1098	S1 RNA binding domain
THEBR_RS01320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THEBR_RS01320	COG0248	Ppx GppA phosphatase
THEBR_RS01340	COG1940	carbohydrate kinase activity
THEBR_RS01345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THEBR_RS01350	COG1175	transmembrane transport
THEBR_RS01355	COG0395	ABC-type sugar transport system, permease component
THEBR_RS01365	COG3387	PFAM Glycoside hydrolase 15-related
THEBR_RS01380	COG2801	Transposase and inactivated derivatives
THEBR_RS01385	COG3328	transposase activity
THEBR_RS01400	COG0745	RESPONSE REGULATOR receiver
THEBR_RS01405	COG2205	protein histidine kinase activity
THEBR_RS01420	COG2217	Heavy metal translocating P-type atpase
THEBR_RS01425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THEBR_RS01435	COG0482	sulfurtransferase activity
THEBR_RS01440	COG2217	Heavy metal translocating P-type atpase
THEBR_RS01445	COG5001	Diguanylate cyclase
THEBR_RS01445	COG3300	MHYT domain
THEBR_RS01465	COG0156	8-amino-7-oxononanoate synthase activity
THEBR_RS01470	COG1063	alcohol dehydrogenase
THEBR_RS01490	COG1131	(ABC) transporter
THEBR_RS01505	COG0697	spore germination
THEBR_RS01520	COG2208	phosphoserine phosphatase activity
THEBR_RS01525	COG0037	tRNA processing
THEBR_RS01530	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THEBR_RS01540	COG3852	Histidine kinase
THEBR_RS01545	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THEBR_RS01555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THEBR_RS01565	COG0511	ligase activity, forming carbon-carbon bonds
THEBR_RS01565	COG5016	pyruvate
THEBR_RS01570	COG4684	Psort location CytoplasmicMembrane, score
THEBR_RS01580	COG0531	amino acid
THEBR_RS01585	COG0697	spore germination
THEBR_RS01610	COG5322	oxidoreductase activity
THEBR_RS01610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THEBR_RS01620	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THEBR_RS01630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THEBR_RS01635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THEBR_RS01640	COG0720	synthase
THEBR_RS01650	COG4946	Tricorn protease homolog
THEBR_RS01650	COG0823	Involved in the tonB-independent uptake of proteins
THEBR_RS01650	COG1506	peptidase
THEBR_RS01685	COG3711	transcriptional antiterminator
THEBR_RS01685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEBR_RS01690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEBR_RS01690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEBR_RS01690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEBR_RS01700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEBR_RS01705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEBR_RS01710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THEBR_RS01715	COG0281	malic enzyme
THEBR_RS01730	COG3880	PFAM UvrB UvrC protein
THEBR_RS01735	COG3869	Catalyzes the specific phosphorylation of arginine residues in
THEBR_RS01740	COG0542	response to heat
THEBR_RS01745	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THEBR_RS01755	COG4956	integral membrane protein (PIN domain superfamily)
THEBR_RS01760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THEBR_RS01770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THEBR_RS01775	COG0442	prolyl-tRNA aminoacylation
THEBR_RS01785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THEBR_RS01790	COG1045	serine acetyltransferase
THEBR_RS01805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THEBR_RS01810	COG3688	RNA-binding protein containing a PIN domain
THEBR_RS01815	COG1595	DNA-templated transcription, initiation
THEBR_RS01825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THEBR_RS01830	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THEBR_RS01835	COG0250	Participates in transcription elongation, termination and antitermination
THEBR_RS01845	COG0081	regulation of translation
THEBR_RS01850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THEBR_RS01855	COG0222	ribosome binding
THEBR_RS01860	COG0085	RNA polymerase activity
THEBR_RS01865	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THEBR_RS01870	COG1358	cellular component organization or biogenesis
THEBR_RS01875	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THEBR_RS01880	COG0049	tRNA binding
THEBR_RS01890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THEBR_RS01900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THEBR_RS01930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THEBR_RS01935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THEBR_RS01975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THEBR_RS01995	COG0201	protein transport
THEBR_RS02015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THEBR_RS02050	COG1122	ATPase activity
THEBR_RS02055	COG1122	ATPase activity
THEBR_RS02060	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THEBR_RS02140	COG4555	ABC transporter
THEBR_RS02200	COG3328	transposase activity
THEBR_RS02205	COG2801	Transposase and inactivated derivatives
THEBR_RS02220	COG2033	superoxide reductase activity
THEBR_RS02240	COG1966	Carbon starvation protein
THEBR_RS02245	COG1115	amino acid carrier protein
THEBR_RS02250	COG1863	multisubunit Na H antiporter MnhE subunit
THEBR_RS02260	COG1320	monovalent cation:proton antiporter activity
THEBR_RS02280	COG0651	ATP synthesis coupled electron transport
THEBR_RS02285	COG0651	ATP synthesis coupled electron transport
THEBR_RS02295	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THEBR_RS02320	COG1705	Flagellar rod assembly protein muramidase FlgJ
THEBR_RS02320	COG1388	LysM domain
THEBR_RS02330	COG0546	phosphoglycolate phosphatase activity
THEBR_RS02345	COG0714	Associated with various cellular activities
THEBR_RS02370	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
THEBR_RS02380	COG3426	butyrate kinase activity
THEBR_RS02385	COG0280	phosphate acetyltransferase
THEBR_RS02395	COG3426	butyrate kinase activity
THEBR_RS02425	COG0280	phosphate acetyltransferase
THEBR_RS02435	COG0204	Acyl-transferase
THEBR_RS02435	COG0318	PFAM AMP-dependent synthetase and ligase
THEBR_RS02440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THEBR_RS02445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THEBR_RS02455	COG0432	Pfam Uncharacterised protein family UPF0047
THEBR_RS02460	COG1793	dna ligase
THEBR_RS02465	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
THEBR_RS02485	COG1151	hydroxylamine reductase activity
THEBR_RS02510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THEBR_RS02510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THEBR_RS02520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THEBR_RS02530	COG2337	Toxic component of a toxin-antitoxin (TA) module
THEBR_RS02535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THEBR_RS02540	COG3959	Transketolase, thiamine diphosphate binding domain
THEBR_RS02545	COG3958	Transketolase
THEBR_RS02555	COG0205	6-phosphofructokinase activity
THEBR_RS02560	COG1757	Na H antiporter
THEBR_RS02565	COG2205	protein histidine kinase activity
THEBR_RS02570	COG1773	rubredoxin
THEBR_RS02575	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THEBR_RS02585	COG0460	homoserine dehydrogenase
THEBR_RS02590	COG2873	o-acetylhomoserine
THEBR_RS02595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THEBR_RS02600	COG0673	inositol 2-dehydrogenase activity
THEBR_RS02605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THEBR_RS02605	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
THEBR_RS02610	COG3459	Glycosyltransferase 36 associated
THEBR_RS02615	COG1131	(ABC) transporter
THEBR_RS02650	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THEBR_RS02660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THEBR_RS02665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THEBR_RS02670	COG0131	Imidazoleglycerol-phosphate dehydratase
THEBR_RS02675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THEBR_RS02690	COG0140	phosphoribosyl-ATP diphosphatase activity
THEBR_RS02690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THEBR_RS02695	COG3344	reverse transcriptase
THEBR_RS02710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THEBR_RS02715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THEBR_RS02725	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THEBR_RS02745	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
THEBR_RS02750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THEBR_RS02755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
THEBR_RS02765	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEBR_RS02775	COG3290	protein histidine kinase activity
THEBR_RS02775	COG3829	transcription factor binding
THEBR_RS02780	COG2376	Dihydroxyacetone kinase
THEBR_RS02790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEBR_RS02790	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
THEBR_RS02790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEBR_RS02795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THEBR_RS02835	COG0849	cell division
THEBR_RS02855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THEBR_RS02870	COG0019	diaminopimelate decarboxylase activity
THEBR_RS02880	COG3842	ATPase activity
THEBR_RS02885	COG3835	regulator
THEBR_RS02890	COG2884	Cell division ATP-binding protein ftsE
THEBR_RS02895	COG2177	Part of the ABC transporter FtsEX involved in
THEBR_RS02900	COG0739	heme binding
THEBR_RS02905	COG0793	Belongs to the peptidase S41A family
THEBR_RS02905	COG3409	Peptidoglycan-binding domain 1 protein
THEBR_RS02910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEBR_RS02915	COG2045	Belongs to the ComB family
THEBR_RS02920	COG0556	nucleotide-excision repair
THEBR_RS02930	COG1716	ATPase activity
THEBR_RS02940	COG0768	penicillin binding
THEBR_RS02945	COG0322	excinuclease ABC activity
THEBR_RS02965	COG1940	carbohydrate kinase activity
THEBR_RS02970	COG0318	PFAM AMP-dependent synthetase and ligase
THEBR_RS02980	COG3885	ferrous iron binding
THEBR_RS02980	COG2078	PFAM AMMECR1 domain protein
THEBR_RS03025	COG0673	inositol 2-dehydrogenase activity
THEBR_RS03030	COG0673	inositol 2-dehydrogenase activity
THEBR_RS03055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THEBR_RS03060	COG1349	DNA-binding transcription factor activity
THEBR_RS03070	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THEBR_RS03090	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
THEBR_RS03095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THEBR_RS03100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THEBR_RS03105	COG1940	carbohydrate kinase activity
THEBR_RS03115	COG1653	transport
THEBR_RS03120	COG1175	transmembrane transport
THEBR_RS03125	COG0395	ABC-type sugar transport system, permease component
THEBR_RS03135	COG3250	beta-galactosidase activity
THEBR_RS03140	COG0383	alpha-mannosidase activity
THEBR_RS03145	COG1653	transport
THEBR_RS03150	COG1175	transmembrane transport
THEBR_RS03155	COG0395	ABC-type sugar transport system, permease component
THEBR_RS03165	COG1917	Cupin 2, conserved barrel domain protein
THEBR_RS03165	COG4977	sequence-specific DNA binding
THEBR_RS03175	COG0733	neurotransmitter:sodium symporter activity
THEBR_RS03195	COG0768	penicillin binding
THEBR_RS03205	COG2182	Extracellular solute-binding protein
THEBR_RS03220	COG1621	beta-fructofuranosidase activity
THEBR_RS03225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THEBR_RS03230	COG1609	Transcriptional regulator
THEBR_RS03250	COG2226	methyltransferase
THEBR_RS03265	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THEBR_RS03270	COG0489	protein tyrosine kinase activity
THEBR_RS03285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEBR_RS03290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THEBR_RS03295	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEBR_RS03305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THEBR_RS03310	COG1120	ATPase activity
THEBR_RS03350	COG1342	Belongs to the UPF0251 family
THEBR_RS03365	COG3464	Transposase
THEBR_RS03375	COG1752	Esterase of the alpha-beta hydrolase superfamily
THEBR_RS03380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THEBR_RS03405	COG2182	Extracellular solute-binding protein
THEBR_RS03410	COG1175	transmembrane transport
THEBR_RS03415	COG3833	ABC-type maltose transport systems, permease component
THEBR_RS03435	COG1426	Protein conserved in bacteria
THEBR_RS03440	COG0366	Alpha amylase catalytic
THEBR_RS03450	COG1481	regulation of sporulation
THEBR_RS03455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEBR_RS03460	COG4109	DRTGG domain
THEBR_RS03490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THEBR_RS03505	COG0534	Mate efflux family protein
THEBR_RS03510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEBR_RS03525	COG2195	Cleaves the N-terminal amino acid of tripeptides
THEBR_RS03530	COG0778	Nitroreductase
THEBR_RS03535	COG0166	Belongs to the GPI family
THEBR_RS03540	COG0058	SHG alpha-glucan phosphorylase activity
THEBR_RS03550	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THEBR_RS03550	COG0646	methionine synthase
THEBR_RS03555	COG1410	methionine synthase
THEBR_RS03555	COG0646	methionine synthase
THEBR_RS03560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
THEBR_RS03565	COG3546	catalase activity
THEBR_RS03575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THEBR_RS03600	COG0463	Glycosyl transferase, family 2
THEBR_RS03605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THEBR_RS03615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THEBR_RS03630	COG0564	pseudouridine synthase activity
THEBR_RS03640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THEBR_RS03675	COG1067	ATP-dependent peptidase activity
THEBR_RS03680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THEBR_RS03685	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THEBR_RS03690	COG2720	vancomycin resistance protein
THEBR_RS03700	COG0561	phosphatase activity
THEBR_RS03705	COG1254	Belongs to the acylphosphatase family
THEBR_RS03710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
THEBR_RS03715	COG2390	Transcriptional regulator
THEBR_RS03725	COG0126	phosphoglycerate kinase activity
THEBR_RS03730	COG0149	triose-phosphate isomerase activity
THEBR_RS03735	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THEBR_RS03740	COG0148	phosphopyruvate hydratase activity
THEBR_RS03745	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THEBR_RS03750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THEBR_RS03755	COG0358	DNA primase activity
THEBR_RS03760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THEBR_RS03775	COG2384	SAM-dependent methyltransferase
THEBR_RS03780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THEBR_RS03790	COG1482	cell wall glycoprotein biosynthetic process
THEBR_RS03800	COG0475	glutathione-regulated potassium exporter activity
THEBR_RS03815	COG0701	Predicted permease
THEBR_RS03825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THEBR_RS03845	COG1956	GAF domain-containing protein
THEBR_RS03850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
THEBR_RS03860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THEBR_RS03900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THEBR_RS03905	COG0745	RESPONSE REGULATOR receiver
THEBR_RS03920	COG4399	Belongs to the UPF0754 family
THEBR_RS03925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THEBR_RS03935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THEBR_RS03940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THEBR_RS03945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THEBR_RS03950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THEBR_RS03955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THEBR_RS03960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THEBR_RS03965	COG0072	phenylalanine-tRNA ligase activity
THEBR_RS03965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEBR_RS03975	COG0826	peptidase U32
THEBR_RS03980	COG1193	negative regulation of DNA recombination
THEBR_RS03985	COG1683	Conserved Protein
THEBR_RS04005	COG2197	response regulator
THEBR_RS04010	COG1362	aminopeptidase activity
THEBR_RS04015	COG2340	Cysteine-rich secretory protein family
THEBR_RS04030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THEBR_RS04035	COG0321	lipoyl(octanoyl) transferase activity
THEBR_RS04040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THEBR_RS04050	COG0459	protein refolding
THEBR_RS04055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
THEBR_RS04060	COG0022	dehydrogenase e1 component
THEBR_RS04065	COG3199	ATP-NAD kinase
THEBR_RS04070	COG0508	dehydrogenase complex catalyzes the overall conversion of
THEBR_RS04095	COG0301	tRNA thio-modification
THEBR_RS04105	COG0012	GTP binding
THEBR_RS04115	COG0612	Peptidase, M16
THEBR_RS04120	COG0612	Peptidase, M16
THEBR_RS04125	COG2001	Belongs to the MraZ family
THEBR_RS04130	COG0275	rRNA processing
THEBR_RS04135	COG3116	cell division
THEBR_RS04140	COG0768	penicillin binding
THEBR_RS04145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THEBR_RS04150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THEBR_RS04160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THEBR_RS04165	COG0772	Belongs to the SEDS family
THEBR_RS04175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THEBR_RS04190	COG3856	small basic protein
THEBR_RS04195	COG0849	cell division
THEBR_RS04200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THEBR_RS04210	COG1191	sigma factor activity
THEBR_RS04215	COG1191	sigma factor activity
THEBR_RS04220	COG1873	PFAM PRC-barrel domain
THEBR_RS04225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THEBR_RS04230	COG0745	RESPONSE REGULATOR receiver
THEBR_RS04235	COG5002	protein histidine kinase activity
THEBR_RS04240	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THEBR_RS04245	COG0573	inorganic phosphate transmembrane transporter activity
THEBR_RS04250	COG0581	inorganic phosphate transmembrane transporter activity
THEBR_RS04255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THEBR_RS04260	COG0704	Plays a role in the regulation of phosphate uptake
THEBR_RS04300	COG1160	GTP binding
THEBR_RS04305	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THEBR_RS04310	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THEBR_RS04315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
THEBR_RS04335	COG3835	regulator
THEBR_RS04350	COG2414	aldehyde ferredoxin oxidoreductase
THEBR_RS04365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THEBR_RS04390	COG0521	Mo-molybdopterin cofactor biosynthetic process
THEBR_RS04395	COG0303	'Molybdopterin
THEBR_RS04400	COG1910	domain protein
THEBR_RS04410	COG0315	cyclic pyranopterin monophosphate synthase activity
THEBR_RS04425	COG4948	Mandelate Racemase Muconate Lactonizing
THEBR_RS04440	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THEBR_RS04455	COG2302	S4 RNA-binding domain
THEBR_RS04460	COG3599	regulation of cell shape
THEBR_RS04485	COG2188	Transcriptional regulator
THEBR_RS04500	COG1122	ATPase activity
THEBR_RS04510	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THEBR_RS04535	COG3344	reverse transcriptase
THEBR_RS04545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THEBR_RS04545	COG0512	Glutamine amidotransferase of anthranilate synthase
THEBR_RS04555	COG0134	indole-3-glycerol-phosphate synthase activity
THEBR_RS04560	COG0135	phosphoribosylanthranilate isomerase activity
THEBR_RS04565	COG0133	tryptophan synthase activity
THEBR_RS04570	COG0159	tryptophan synthase activity
THEBR_RS04575	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THEBR_RS04580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THEBR_RS04585	COG0626	cystathionine gamma-synthase activity
THEBR_RS04615	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEBR_RS04615	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEBR_RS04620	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEBR_RS04620	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEBR_RS04625	COG1703	isobutyryl-CoA mutase activity
THEBR_RS04630	COG0346	lactoylglutathione lyase activity
THEBR_RS04640	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
THEBR_RS04655	COG1595	DNA-templated transcription, initiation
THEBR_RS04660	COG0778	Nitroreductase
THEBR_RS04670	COG1970	mechanosensitive ion channel activity
THEBR_RS04745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THEBR_RS04785	COG1132	(ABC) transporter
THEBR_RS04835	COG1132	(ABC) transporter
THEBR_RS04860	COG1132	(ABC) transporter
THEBR_RS04890	COG0693	protein deglycase activity
THEBR_RS04900	COG2267	carboxylic ester hydrolase activity
THEBR_RS04905	COG3344	reverse transcriptase
THEBR_RS04920	COG0584	glycerophosphoryl diester phosphodiesterase
THEBR_RS04930	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THEBR_RS04935	COG1968	undecaprenyl-diphosphatase activity
THEBR_RS04950	COG3069	C4-dicarboxylate transmembrane transporter activity
THEBR_RS04960	COG0426	domain, Protein
THEBR_RS04965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THEBR_RS04975	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
THEBR_RS04980	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THEBR_RS04985	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
THEBR_RS05000	COG1760	l-serine dehydratase
THEBR_RS05005	COG1164	Oligoendopeptidase f
THEBR_RS05010	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THEBR_RS05015	COG0077	Prephenate dehydratase
THEBR_RS05015	COG1605	Chorismate mutase
THEBR_RS05020	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THEBR_RS05025	COG0287	Prephenate dehydrogenase
THEBR_RS05040	COG2119	membrane
THEBR_RS05055	COG0363	glucosamine-6-phosphate deaminase activity
THEBR_RS05060	COG0785	Cytochrome C biogenesis protein
THEBR_RS05065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THEBR_RS05070	COG3118	belongs to the thioredoxin family
THEBR_RS05075	COG1982	Orn Lys Arg decarboxylase major
THEBR_RS05100	COG2385	sporulation resulting in formation of a cellular spore
THEBR_RS05105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THEBR_RS05120	COG1739	Uncharacterized protein family UPF0029
THEBR_RS05140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THEBR_RS05150	COG0835	chemotaxis
THEBR_RS05160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THEBR_RS05180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THEBR_RS05185	COG0343	queuine tRNA-ribosyltransferase activity
THEBR_RS05200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THEBR_RS05205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THEBR_RS05210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THEBR_RS05215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THEBR_RS05215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THEBR_RS05225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THEBR_RS05225	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THEBR_RS05230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THEBR_RS05235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THEBR_RS05240	COG1490	D-aminoacyl-tRNA deacylase activity
THEBR_RS05245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEBR_RS05250	COG0577	efflux transmembrane transporter activity
THEBR_RS05255	COG1136	(ABC) transporter
THEBR_RS05270	COG0124	histidyl-tRNA synthetase
THEBR_RS05275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THEBR_RS05280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THEBR_RS05285	COG1937	Protein conserved in bacteria
THEBR_RS05290	COG3118	belongs to the thioredoxin family
THEBR_RS05295	COG3118	belongs to the thioredoxin family
THEBR_RS05300	COG3804	dihydrodipicolinate reductase
THEBR_RS05310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THEBR_RS05320	COG5012	cobalamin binding
THEBR_RS05330	COG3457	Alanine racemase
THEBR_RS05335	COG0346	lactoylglutathione lyase activity
THEBR_RS05340	COG1959	2 iron, 2 sulfur cluster binding
THEBR_RS05350	COG0628	permease
THEBR_RS05360	COG4472	Bacterial protein of unknown function (DUF965)
THEBR_RS05365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THEBR_RS05370	COG3906	Belongs to the UPF0473 family
THEBR_RS05375	COG0735	belongs to the Fur family
THEBR_RS05380	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
THEBR_RS05385	COG3679	Belongs to the UPF0342 family
THEBR_RS05390	COG4708	membrane
THEBR_RS05395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THEBR_RS05400	COG4122	O-methyltransferase activity
THEBR_RS05405	COG0826	peptidase U32
THEBR_RS05410	COG0768	penicillin binding
THEBR_RS05420	COG0546	phosphoglycolate phosphatase activity
THEBR_RS05425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THEBR_RS05430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THEBR_RS05440	COG1459	type II secretion system
THEBR_RS05450	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THEBR_RS05495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THEBR_RS05510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THEBR_RS05520	COG0006	proline dipeptidase activity
THEBR_RS05535	COG3854	ATPases associated with a variety of cellular activities
THEBR_RS05575	COG1302	Protein conserved in bacteria
THEBR_RS05585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THEBR_RS05590	COG1570	exodeoxyribonuclease VII activity
THEBR_RS05595	COG1722	exodeoxyribonuclease VII activity
THEBR_RS05610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THEBR_RS05615	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
THEBR_RS05625	COG1438	arginine binding
THEBR_RS05630	COG0497	DNA recombination
THEBR_RS05635	COG0750	zinc metalloprotease
THEBR_RS05675	COG1379	DNA repair
THEBR_RS05680	COG1300	Membrane
THEBR_RS05685	COG4974	Belongs to the 'phage' integrase family
THEBR_RS05690	COG1686	Belongs to the peptidase S11 family
THEBR_RS05695	COG1366	Belongs to the anti-sigma-factor antagonist family
THEBR_RS05710	COG3360	Dodecin
THEBR_RS05730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEBR_RS05730	COG0517	IMP dehydrogenase activity
THEBR_RS05730	COG0617	tRNA 3'-terminal CCA addition
THEBR_RS05735	COG1994	Peptidase M50
THEBR_RS05745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THEBR_RS05750	COG4086	secreted protein
THEBR_RS05760	COG3874	Sporulation protein YtfJ
THEBR_RS05765	COG1301	dicarboxylic acid transport
THEBR_RS05770	COG1030	water channel activity
THEBR_RS05785	COG1686	Belongs to the peptidase S11 family
THEBR_RS05795	COG0445	tRNA wobble uridine modification
THEBR_RS05800	COG1187	pseudouridine synthase activity
THEBR_RS05815	COG0010	Belongs to the arginase family
THEBR_RS05825	COG1388	LysM domain
THEBR_RS05825	COG1705	Flagellar rod assembly protein muramidase FlgJ
THEBR_RS05845	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THEBR_RS05845	COG0674	pyruvate-flavodoxin oxidoreductase activity
THEBR_RS05850	COG1013	pyruvate-flavodoxin oxidoreductase activity
THEBR_RS05875	COG1914	H( )-stimulated, divalent metal cation uptake system
THEBR_RS05880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
THEBR_RS05885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
THEBR_RS05890	COG1984	allophanate hydrolase subunit 2
THEBR_RS05905	COG0406	alpha-ribazole phosphatase activity
THEBR_RS05910	COG2081	HI0933 family
THEBR_RS05925	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THEBR_RS05940	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THEBR_RS05940	COG0539	negative regulation of cytoplasmic translation
THEBR_RS05950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THEBR_RS05955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEBR_RS05960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THEBR_RS05965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THEBR_RS05980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THEBR_RS05990	COG4974	Belongs to the 'phage' integrase family
THEBR_RS05995	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
THEBR_RS06000	COG0464	growth
THEBR_RS06005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THEBR_RS06015	COG0613	PHP domain protein
THEBR_RS06020	COG2359	stage V sporulation protein S
THEBR_RS06025	COG1692	metallophosphoesterase
THEBR_RS06030	COG1418	mRNA catabolic process
THEBR_RS06040	COG2137	regulation of response to DNA damage stimulus
THEBR_RS06045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THEBR_RS06050	COG1546	Belongs to the CinA family
THEBR_RS06050	COG1058	Belongs to the CinA family
THEBR_RS06055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THEBR_RS06060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEBR_RS06065	COG1674	ftsk spoiiie
THEBR_RS06075	COG0740	serine-type endopeptidase activity
THEBR_RS06080	COG0527	aspartate kinase activity
THEBR_RS06095	COG0612	Peptidase, M16
THEBR_RS06100	COG0726	polysaccharide deacetylase
THEBR_RS06105	COG1185	polyribonucleotide nucleotidyltransferase activity
THEBR_RS06115	COG0196	riboflavin kinase activity
THEBR_RS06120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THEBR_RS06125	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEBR_RS06130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THEBR_RS06135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THEBR_RS06145	COG2740	Nucleic-acid-binding protein implicated in transcription termination
THEBR_RS06150	COG0195	Participates in both transcription termination and antitermination
THEBR_RS06155	COG0779	Required for maturation of 30S ribosomal subunits
THEBR_RS06160	COG2176	DNA-directed DNA polymerase activity
THEBR_RS06170	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THEBR_RS06175	COG0750	zinc metalloprotease
THEBR_RS06180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THEBR_RS06185	COG4589	Belongs to the CDS family
THEBR_RS06190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THEBR_RS06205	COG0528	UMP kinase activity
THEBR_RS06215	COG0052	Belongs to the universal ribosomal protein uS2 family
THEBR_RS06230	COG1191	sigma factor activity
THEBR_RS06235	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THEBR_RS06240	COG1776	CheC inhibitor of MCP methylation
THEBR_RS06245	COG0835	chemotaxis
THEBR_RS06250	COG2198	Histidine kinase
THEBR_RS06250	COG0643	Histidine kinase
THEBR_RS06255	COG2201	protein-glutamate methylesterase activity
THEBR_RS06265	COG0455	bacterial-type flagellum organization
THEBR_RS06270	COG1419	protein localization to endoplasmic reticulum
THEBR_RS06275	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THEBR_RS06280	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THEBR_RS06285	COG1684	flagellar biosynthetic protein fliR
THEBR_RS06290	COG1987	bacterial-type flagellum assembly
THEBR_RS06295	COG1338	Plays a role in the flagellum-specific transport system
THEBR_RS06305	COG2201	protein-glutamate methylesterase activity
THEBR_RS06310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THEBR_RS06310	COG1776	CheC inhibitor of MCP methylation
THEBR_RS06315	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THEBR_RS06325	COG1582	Flagellar protein (FlbD)
THEBR_RS06340	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THEBR_RS06360	COG1157	protein secretion by the type III secretion system
THEBR_RS06370	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THEBR_RS06375	COG1766	The M ring may be actively involved in energy transduction
THEBR_RS06380	COG1677	Flagellar hook-basal body complex protein FliE
THEBR_RS06390	COG1815	bacterial-type flagellum-dependent cell motility
THEBR_RS06395	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
THEBR_RS06400	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THEBR_RS06405	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THEBR_RS06410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THEBR_RS06415	COG0758	DNA mediated transformation
THEBR_RS06415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THEBR_RS06420	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THEBR_RS06425	COG0792	nuclease activity
THEBR_RS06430	COG0180	Tryptophanyl-tRNA synthetase
THEBR_RS06435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THEBR_RS06440	COG0606	chelatase, subunit chli
THEBR_RS06455	COG0336	Belongs to the RNA methyltransferase TrmD family
THEBR_RS06465	COG1837	Belongs to the UPF0109 family
THEBR_RS06470	COG0228	four-way junction DNA binding
THEBR_RS06475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THEBR_RS06480	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
THEBR_RS06485	COG0552	protein localization to endoplasmic reticulum
THEBR_RS06500	COG2359	stage V sporulation protein S
THEBR_RS06510	COG0571	ribonuclease III activity
THEBR_RS06515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THEBR_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
THEBR_RS06530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THEBR_RS06535	COG2070	2-Nitropropane dioxygenase
THEBR_RS06540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THEBR_RS06545	COG0416	fatty acid biosynthetic process
THEBR_RS06555	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THEBR_RS06560	COG1399	metal-binding, possibly nucleic acid-binding protein
THEBR_RS06565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THEBR_RS06570	COG0280	phosphate acetyltransferase
THEBR_RS06575	COG1323	Belongs to the UPF0348 family
THEBR_RS06580	COG3314	Sporulation integral membrane protein YlbJ
THEBR_RS06595	COG0742	ribosomal rna small subunit methyltransferase
THEBR_RS06610	COG1307	EDD domain protein, DegV family
THEBR_RS06615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THEBR_RS06620	COG1461	Dihydroxyacetone kinase
THEBR_RS06625	COG1302	Protein conserved in bacteria
THEBR_RS06630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THEBR_RS06645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THEBR_RS06650	COG1162	GTPase activity
THEBR_RS06655	COG2815	serine threonine protein kinase
THEBR_RS06655	COG0515	serine threonine protein kinase
THEBR_RS06660	COG0631	protein serine/threonine phosphatase activity
THEBR_RS06670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THEBR_RS06670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THEBR_RS06675	COG2738	Putative neutral zinc metallopeptidase
THEBR_RS06685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THEBR_RS06690	COG0242	peptide deformylase activity
THEBR_RS06695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THEBR_RS06700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THEBR_RS06705	COG1758	RNA polymerase activity
THEBR_RS06710	COG0194	GDP metabolic process
THEBR_RS06720	COG1561	YicC-like family, N-terminal region
THEBR_RS06725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THEBR_RS06730	COG2814	Major facilitator Superfamily
THEBR_RS06750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
THEBR_RS06755	COG2011	ABC-type metal ion transport system permease component
THEBR_RS06785	COG0037	tRNA processing
THEBR_RS06805	COG0167	dihydroorotate dehydrogenase activity
THEBR_RS06810	COG0543	2 iron, 2 sulfur cluster binding
THEBR_RS06815	COG0284	orotidine-5'-phosphate decarboxylase activity
THEBR_RS06825	COG0540	Belongs to the ATCase OTCase family
THEBR_RS06840	COG0564	pseudouridine synthase activity
THEBR_RS06845	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THEBR_RS06850	COG3063	Type IV pilus biogenesis stability protein PilW
THEBR_RS06880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THEBR_RS06885	COG0557	exoribonuclease II activity
THEBR_RS06895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEBR_RS06895	COG0574	Belongs to the PEP-utilizing enzyme family
THEBR_RS06905	COG0517	IMP dehydrogenase activity
THEBR_RS06910	COG0423	glycine-tRNA ligase activity
THEBR_RS06920	COG1381	Involved in DNA repair and RecF pathway recombination
THEBR_RS06925	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
THEBR_RS06935	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THEBR_RS06945	COG1480	7TM receptor with intracellular HD hydrolase
THEBR_RS06950	COG1702	phosphate starvation-inducible protein PhoH
THEBR_RS06980	COG0537	adenosine 5'-monophosphoramidase activity
THEBR_RS06985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEBR_RS06990	COG5002	protein histidine kinase activity
THEBR_RS06990	COG5001	Diguanylate cyclase
THEBR_RS06990	COG3447	MASE1 domain protein
THEBR_RS06995	COG0840	transmembrane signaling receptor activity
THEBR_RS07025	COG2274	protein secretion by the type I secretion system
THEBR_RS07030	COG0488	(ABC) transporter
THEBR_RS07065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THEBR_RS07070	COG2264	protein methyltransferase activity
THEBR_RS07075	COG0484	heat shock protein binding
THEBR_RS07080	COG0443	Heat shock 70 kDa protein
THEBR_RS07085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THEBR_RS07090	COG1420	regulation of RNA biosynthetic process
THEBR_RS07095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THEBR_RS07100	COG0481	GTPase activity
THEBR_RS07120	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THEBR_RS07130	COG0268	Binds directly to 16S ribosomal RNA
THEBR_RS07145	COG1234	tRNA 3'-trailer cleavage
THEBR_RS07155	COG4720	Psort location CytoplasmicMembrane, score
THEBR_RS07170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THEBR_RS07210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THEBR_RS07215	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THEBR_RS07220	COG1596	polysaccharide export
THEBR_RS07220	COG1555	photosystem II stabilization
THEBR_RS07225	COG1686	Belongs to the peptidase S11 family
THEBR_RS07230	COG0367	asparagine synthase
THEBR_RS07250	COG0799	negative regulation of ribosome biogenesis
THEBR_RS07255	COG1713	HD superfamily hydrolase involved in NAD metabolism
THEBR_RS07265	COG3344	reverse transcriptase
THEBR_RS07305	COG4708	membrane
THEBR_RS07315	COG1530	ribonuclease E activity
THEBR_RS07330	COG1994	Peptidase M50
THEBR_RS07330	COG0517	IMP dehydrogenase activity
THEBR_RS07335	COG0739	heme binding
THEBR_RS07345	COG0772	Belongs to the SEDS family
THEBR_RS07355	COG2894	cell division
THEBR_RS07365	COG0768	penicillin binding
THEBR_RS07380	COG1077	Cell shape determining protein MreB Mrl
THEBR_RS07385	COG2003	Belongs to the UPF0758 family
THEBR_RS07415	COG4191	Histidine kinase
THEBR_RS07415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THEBR_RS07435	COG2878	Part of a membrane complex involved in electron transport
THEBR_RS07455	COG0741	lytic transglycosylase activity
THEBR_RS07460	COG1217	gtp-binding protein TYPA
THEBR_RS07465	COG0791	NLP P60 protein
THEBR_RS07465	COG1388	LysM domain
THEBR_RS07485	COG0741	lytic transglycosylase activity
THEBR_RS07490	COG0237	dephospho-CoA kinase activity
THEBR_RS07495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THEBR_RS07495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THEBR_RS07520	COG4475	Protein of unknown function (DUF436)
THEBR_RS07560	COG2986	histidine ammonia-lyase
THEBR_RS07575	COG0739	heme binding
THEBR_RS07590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THEBR_RS07595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
THEBR_RS07615	COG1132	(ABC) transporter
THEBR_RS07620	COG1132	(ABC) transporter
THEBR_RS07630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THEBR_RS07640	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THEBR_RS07645	COG2171	N-acyltransferase activity
THEBR_RS07650	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
THEBR_RS07665	COG3773	Cell wall hydrolase
THEBR_RS07665	COG3409	Peptidoglycan-binding domain 1 protein
THEBR_RS07670	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEBR_RS07670	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEBR_RS07700	COG0395	ABC-type sugar transport system, permease component
THEBR_RS07715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THEBR_RS07720	COG0395	ABC-type sugar transport system, permease component
THEBR_RS07725	COG1175	transmembrane transport
THEBR_RS07740	COG1609	Transcriptional regulator
THEBR_RS07745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THEBR_RS07775	COG0285	dihydrofolate synthase activity
THEBR_RS07785	COG0525	valine-tRNA ligase activity
THEBR_RS07810	COG0745	RESPONSE REGULATOR receiver
THEBR_RS07815	COG5002	protein histidine kinase activity
THEBR_RS07820	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THEBR_RS07825	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THEBR_RS07830	COG1691	(AIR) carboxylase
THEBR_RS07835	COG1606	tRNA processing
THEBR_RS07840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THEBR_RS07850	COG0671	phosphoesterase, PA-phosphatase related
THEBR_RS07865	COG2814	Major facilitator Superfamily
THEBR_RS07880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THEBR_RS07890	COG3949	Membrane
THEBR_RS07895	COG1316	TRANSCRIPTIONal
THEBR_RS07905	COG0489	protein tyrosine kinase activity
THEBR_RS07910	COG3944	biosynthesis protein
THEBR_RS07915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THEBR_RS07925	COG0250	Participates in transcription elongation, termination and antitermination
THEBR_RS07935	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
THEBR_RS07980	COG1914	H( )-stimulated, divalent metal cation uptake system
THEBR_RS07990	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THEBR_RS08005	COG4989	oxidoreductase activity
THEBR_RS08010	COG0622	Phosphoesterase
THEBR_RS08015	COG1704	LemA family
THEBR_RS08020	COG0501	Belongs to the peptidase M48B family
THEBR_RS08035	COG2161	toxin-antitoxin pair type II binding
THEBR_RS08050	COG1401	restriction endodeoxyribonuclease activity
THEBR_RS08075	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THEBR_RS08085	COG0789	Transcriptional regulator
THEBR_RS08115	COG1979	alcohol dehydrogenase
THEBR_RS08120	COG0667	Aldo Keto reductase
THEBR_RS08205	COG0622	Phosphoesterase
THEBR_RS08255	COG1091	dTDP-4-dehydrorhamnose reductase activity
THEBR_RS08275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
THEBR_RS08275	COG0463	Glycosyl transferase, family 2
THEBR_RS08320	COG2239	Acts as a magnesium transporter
THEBR_RS08325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THEBR_RS08330	COG1116	anion transmembrane transporter activity
THEBR_RS08335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THEBR_RS08340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THEBR_RS08340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THEBR_RS08355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THEBR_RS08360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THEBR_RS08385	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
THEBR_RS08390	COG0352	thiamine-phosphate diphosphorylase activity
THEBR_RS08395	COG0351	phosphomethylpyrimidine kinase
THEBR_RS08410	COG0437	4 iron, 4 sulfur cluster binding
THEBR_RS08420	COG0067	glutamate synthase
THEBR_RS08425	COG0505	Belongs to the CarA family
THEBR_RS08430	COG0347	Belongs to the P(II) protein family
THEBR_RS08435	COG0004	ammonium transporteR
THEBR_RS08465	COG3464	Transposase
THEBR_RS08490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THEBR_RS08505	COG2721	sulfolactate sulfo-lyase activity
THEBR_RS08560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THEBR_RS08575	COG4608	Belongs to the ABC transporter superfamily
THEBR_RS08580	COG0444	Belongs to the ABC transporter superfamily
THEBR_RS08585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THEBR_RS08590	COG0601	transmembrane transport
THEBR_RS08595	COG4166	transmembrane transport
THEBR_RS08605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THEBR_RS08610	COG0154	amidase activity
THEBR_RS08620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THEBR_RS08625	COG0210	DNA helicase
THEBR_RS08630	COG4496	protein, YerC YecD
THEBR_RS08635	COG1447	Phosphotransferase system cellobiose-specific component IIA
THEBR_RS08640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THEBR_RS08645	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THEBR_RS08655	COG3711	transcriptional antiterminator
THEBR_RS08665	COG2244	polysaccharide biosynthetic process
THEBR_RS08670	COG1473	amidohydrolase
THEBR_RS08675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THEBR_RS08685	COG0151	Belongs to the GarS family
THEBR_RS08690	COG0138	bifunctional purine biosynthesis protein purh
THEBR_RS08695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THEBR_RS08700	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THEBR_RS08705	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THEBR_RS08710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THEBR_RS08715	COG0047	phosphoribosylformylglycinamidine synthase activity
THEBR_RS08720	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THEBR_RS08730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THEBR_RS08735	COG2252	PERMEase
THEBR_RS08740	COG0519	Catalyzes the synthesis of GMP from XMP
THEBR_RS08740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THEBR_RS08745	COG0517	IMP dehydrogenase activity
THEBR_RS08745	COG0516	GMP reductase activity
THEBR_RS08780	COG1404	Belongs to the peptidase S8 family
THEBR_RS08790	COG1811	Na channel or pump
THEBR_RS08805	COG0493	'glutamate synthase
THEBR_RS08825	COG3290	protein histidine kinase activity
THEBR_RS08830	COG3279	Response regulator of the LytR AlgR family
THEBR_RS08840	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
THEBR_RS08865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THEBR_RS08875	COG1214	PFAM Peptidase M22, glycoprotease
THEBR_RS08880	COG0802	atpase or kinase
THEBR_RS08890	COG0549	Belongs to the carbamate kinase family
THEBR_RS08895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THEBR_RS08900	COG2235	arginine
THEBR_RS08910	COG0398	Pfam SNARE associated Golgi protein
THEBR_RS08920	COG2183	response to ionizing radiation
THEBR_RS08925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THEBR_RS08930	COG0653	protein targeting
THEBR_RS08945	COG1827	regulation of RNA biosynthetic process
THEBR_RS08975	COG0765	amino acid transport
THEBR_RS08980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THEBR_RS08985	COG3344	reverse transcriptase
THEBR_RS08995	COG0840	transmembrane signaling receptor activity
THEBR_RS09005	COG1516	flagellar protein fliS
THEBR_RS09010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THEBR_RS09025	COG0367	asparagine synthase
THEBR_RS09055	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THEBR_RS09060	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
THEBR_RS09070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THEBR_RS09075	COG4786	Flagellar basal body rod
THEBR_RS09075	COG1256	bacterial-type flagellum assembly
THEBR_RS09095	COG1040	competence protein
THEBR_RS09100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THEBR_RS09105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THEBR_RS09110	COG1592	Rubrerythrin
THEBR_RS09145	COG5002	protein histidine kinase activity
THEBR_RS09150	COG0745	RESPONSE REGULATOR receiver
THEBR_RS09155	COG1609	Transcriptional regulator
THEBR_RS09160	COG0561	phosphatase activity
THEBR_RS09165	COG2323	membrane
THEBR_RS09180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THEBR_RS09185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
THEBR_RS09195	COG4974	Belongs to the 'phage' integrase family
THEBR_RS09200	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
THEBR_RS09215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THEBR_RS09225	COG2081	HI0933 family
THEBR_RS09275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEBR_RS09280	COG3711	transcriptional antiterminator
THEBR_RS09285	COG2190	(PTS) system
THEBR_RS09290	COG1263	PTS System
THEBR_RS09290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THEBR_RS09290	COG2190	(PTS) system
THEBR_RS09300	COG0840	transmembrane signaling receptor activity
THEBR_RS09320	COG2188	Transcriptional regulator
THEBR_RS09325	COG1079	Belongs to the binding-protein-dependent transport system permease family
THEBR_RS09330	COG4603	Belongs to the binding-protein-dependent transport system permease family
THEBR_RS09335	COG3845	ABC transporter
THEBR_RS09340	COG1744	ABC transporter substrate-binding protein PnrA-like
THEBR_RS09345	COG3404	Formiminotransferase-cyclodeaminase
THEBR_RS09350	COG1228	amidohydrolase
THEBR_RS09360	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
THEBR_RS09365	COG0840	transmembrane signaling receptor activity
THEBR_RS09375	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEBR_RS09375	COG2199	diguanylate cyclase activity
THEBR_RS09440	COG1131	(ABC) transporter
THEBR_RS09510	COG3344	reverse transcriptase
THEBR_RS09540	COG1363	Peptidase, m42
THEBR_RS09585	COG1122	ATPase activity
THEBR_RS09600	COG0310	cobalt ion transport
THEBR_RS09605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THEBR_RS09610	COG0113	porphobilinogen synthase activity
THEBR_RS09635	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
THEBR_RS09645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THEBR_RS09665	COG1492	cobalamin metabolic process
THEBR_RS09670	COG1797	cobyrinic acid a,c-diamide synthase activity
THEBR_RS09675	COG1120	ATPase activity
THEBR_RS09680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THEBR_RS09685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THEBR_RS09700	COG0116	Belongs to the methyltransferase superfamily
THEBR_RS09715	COG0822	iron-sulfur transferase activity
THEBR_RS09720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THEBR_RS09750	COG0583	DNA-binding transcription factor activity
THEBR_RS09755	COG1704	LemA family
THEBR_RS09770	COG0714	Associated with various cellular activities
THEBR_RS09775	COG0735	belongs to the Fur family
THEBR_RS09780	COG0803	Belongs to the bacterial solute-binding protein 9 family
THEBR_RS09785	COG1121	(ABC) transporter
THEBR_RS09790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THEBR_RS09795	COG2723	6-phospho-beta-galactosidase activity
THEBR_RS09800	COG3250	beta-galactosidase activity
THEBR_RS09810	COG0444	Belongs to the ABC transporter superfamily
THEBR_RS09815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THEBR_RS09820	COG0601	transmembrane transport
THEBR_RS09825	COG4166	transmembrane transport
THEBR_RS09840	COG0730	response to heat
THEBR_RS09845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THEBR_RS09850	COG0737	Belongs to the 5'-nucleotidase family
THEBR_RS09855	COG0246	Mannitol dehydrogenase
THEBR_RS09865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEBR_RS09865	COG3711	transcriptional antiterminator
THEBR_RS09870	COG2213	PTS system mannitol-specific
THEBR_RS09875	COG2723	6-phospho-beta-galactosidase activity
THEBR_RS09880	COG1486	melibiose metabolic process
THEBR_RS09885	COG1447	Phosphotransferase system cellobiose-specific component IIA
THEBR_RS09895	COG3394	polysaccharide catabolic process
THEBR_RS09905	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEBR_RS09905	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEBR_RS09920	COG2313	pseudouridylate synthase activity
THEBR_RS09925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THEBR_RS09925	COG1522	sequence-specific DNA binding
THEBR_RS09935	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
THEBR_RS09940	COG0495	leucyl-tRNA aminoacylation
THEBR_RS09950	COG0390	transport system, permease component
THEBR_RS09955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THEBR_RS09965	COG1924	4 iron, 4 sulfur cluster binding
THEBR_RS10000	COG0640	Transcriptional regulator
THEBR_RS10005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THEBR_RS10010	COG0800	Aldolase
THEBR_RS10015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THEBR_RS10025	COG0800	Aldolase
THEBR_RS10030	COG1414	Transcriptional regulator
THEBR_RS10050	COG1979	alcohol dehydrogenase
THEBR_RS10055	COG4821	SIS domain
THEBR_RS10065	COG3037	sugar-specific permease SgaT UlaA
THEBR_RS10075	COG0436	Aminotransferase
THEBR_RS10085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THEBR_RS10090	COG0095	Lipoate-protein ligase
THEBR_RS10095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THEBR_RS10100	COG0509	glycine decarboxylation via glycine cleavage system
THEBR_RS10105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THEBR_RS10110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THEBR_RS10115	COG1980	fructose-bisphosphate aldolase activity
THEBR_RS10160	COG0297	glycogen (starch) synthase activity
THEBR_RS10185	COG0450	alkyl hydroperoxide reductase
THEBR_RS10195	COG0419	ATPase involved in DNA repair
THEBR_RS10200	COG0420	3'-5' exonuclease activity
THEBR_RS10205	COG1074	ATP-dependent DNA helicase activity
THEBR_RS10220	COG0179	Fumarylacetoacetate (FAA) hydrolase
THEBR_RS10225	COG1136	(ABC) transporter
THEBR_RS10225	COG0577	efflux transmembrane transporter activity
THEBR_RS10230	COG1136	(ABC) transporter
THEBR_RS10235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THEBR_RS10240	COG0534	Mate efflux family protein
THEBR_RS10245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THEBR_RS10255	COG0864	Transcriptional regulator
THEBR_RS10260	COG0310	cobalt ion transport
THEBR_RS10265	COG0310	cobalt ion transport
THEBR_RS10270	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THEBR_RS10275	COG1122	ATPase activity
THEBR_RS10280	COG1918	ferrous iron import across plasma membrane
THEBR_RS10280	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THEBR_RS10290	COG1522	sequence-specific DNA binding
THEBR_RS10295	COG0436	Aminotransferase
THEBR_RS10315	COG3328	transposase activity
THEBR_RS10325	COG1879	ABC-type sugar transport system periplasmic component
THEBR_RS10330	COG1172	Belongs to the binding-protein-dependent transport system permease family
THEBR_RS10335	COG1129	ABC transporter
THEBR_RS10345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THEBR_RS10350	COG1609	Transcriptional regulator
THEBR_RS10405	COG2723	6-phospho-beta-galactosidase activity
THEBR_RS10410	COG1472	Belongs to the glycosyl hydrolase 3 family
THEBR_RS10415	COG0395	ABC-type sugar transport system, permease component
THEBR_RS10425	COG1653	transport
THEBR_RS10430	COG1070	Carbohydrate kinase
THEBR_RS10435	COG2115	Belongs to the xylose isomerase family
THEBR_RS10440	COG0569	domain protein
THEBR_RS10445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THEBR_RS10450	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THEBR_RS10455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THEBR_RS10460	COG0800	Aldolase
THEBR_RS10465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THEBR_RS10470	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THEBR_RS10475	COG3716	PTS system mannose fructose sorbose family IID component
THEBR_RS10485	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEBR_RS10490	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEBR_RS10490	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEBR_RS10495	COG2814	Major facilitator Superfamily
THEBR_RS10500	COG0800	Aldolase
THEBR_RS10505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THEBR_RS10510	COG4948	Mandelate Racemase Muconate Lactonizing
THEBR_RS10545	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEBR_RS10545	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEBR_RS10560	COG1496	oxidoreductase activity
THEBR_RS10575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THEBR_RS10595	COG4786	Flagellar basal body rod
THEBR_RS10605	COG1609	Transcriptional regulator
THEBR_RS10615	COG2385	sporulation resulting in formation of a cellular spore
THEBR_RS10625	COG0686	Belongs to the AlaDH PNT family
THEBR_RS10630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THEBR_RS10655	COG0698	ribose 5-phosphate isomerase
THEBR_RS10660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THEBR_RS10665	COG0009	L-threonylcarbamoyladenylate synthase
THEBR_RS10670	COG0428	transporter
THEBR_RS10675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THEBR_RS10685	COG3872	metal-dependent enzyme
THEBR_RS10700	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THEBR_RS10710	COG0745	RESPONSE REGULATOR receiver
THEBR_RS10720	COG2878	Part of a membrane complex involved in electron transport
THEBR_RS10720	COG1245	4Fe-4S binding domain
THEBR_RS10725	COG4657	Part of a membrane complex involved in electron transport
THEBR_RS10730	COG4660	Part of a membrane complex involved in electron transport
THEBR_RS10735	COG4659	FMN binding
THEBR_RS10740	COG4658	electron transport chain
THEBR_RS10745	COG4656	Part of a membrane complex involved in electron transport
THEBR_RS10750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THEBR_RS10765	COG2151	metal-sulfur cluster biosynthetic enzyme
THEBR_RS10765	COG0489	protein tyrosine kinase activity
THEBR_RS10770	COG1191	sigma factor activity
THEBR_RS10775	COG4447	cellulose binding
THEBR_RS10795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THEBR_RS10800	COG3583	domain protein
THEBR_RS10800	COG3584	3D domain protein
THEBR_RS10805	COG0084	hydrolase, TatD family'
THEBR_RS10810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEBR_RS10810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEBR_RS10815	COG0617	tRNA 3'-terminal CCA addition
THEBR_RS10820	COG0700	Nucleoside recognition
THEBR_RS10825	COG2715	membrane protein required for spore maturation
THEBR_RS10830	COG2002	toxin-antitoxin pair type II binding
THEBR_RS10835	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THEBR_RS10840	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THEBR_RS10845	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
THEBR_RS10850	COG2235	arginine
THEBR_RS10855	COG1774	PSP1 C-terminal conserved region
THEBR_RS10860	COG0470	DNA polymerase III
THEBR_RS10870	COG3870	Protein conserved in bacteria
THEBR_RS10880	COG1982	Orn Lys Arg decarboxylase major
THEBR_RS10890	COG0519	Catalyzes the synthesis of GMP from XMP
THEBR_RS10905	COG2391	methyltransferase activity
THEBR_RS10915	COG2391	methyltransferase activity
THEBR_RS10920	COG0583	DNA-binding transcription factor activity
THEBR_RS10960	COG3829	transcription factor binding
THEBR_RS10975	COG1573	uracil-dna glycosylase
THEBR_RS10985	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
THEBR_RS10990	COG0037	tRNA processing
THEBR_RS10995	COG0366	Alpha amylase catalytic
THEBR_RS10995	COG3103	Sh3 type 3 domain protein
THEBR_RS11005	COG1028	Short-chain dehydrogenase reductase Sdr
THEBR_RS11010	COG1181	Belongs to the D-alanine--D-alanine ligase family
THEBR_RS11025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THEBR_RS11030	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THEBR_RS11035	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THEBR_RS11045	COG4608	Belongs to the ABC transporter superfamily
THEBR_RS11050	COG0444	Belongs to the ABC transporter superfamily
THEBR_RS11060	COG0601	transmembrane transport
THEBR_RS11065	COG4166	transmembrane transport
THEBR_RS11070	COG1609	Transcriptional regulator
THEBR_RS11075	COG1187	pseudouridine synthase activity
THEBR_RS11080	COG1028	Short-chain dehydrogenase reductase Sdr
THEBR_RS11125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEBR_RS11130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THEBR_RS11135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THEBR_RS11140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THEBR_RS11145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THEBR_RS11150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THEBR_RS11155	COG2199	diguanylate cyclase activity
THEBR_RS11155	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEBR_RS11255	COG4962	Type ii secretion system protein e
THEBR_RS11280	COG0739	heme binding
THEBR_RS11355	COG1396	sequence-specific DNA binding
THEBR_RS11370	COG0582	viral genome integration into host DNA
THEBR_RS11390	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
THEBR_RS11395	COG0840	transmembrane signaling receptor activity
THEBR_RS11405	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEBR_RS11435	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
THEBR_RS11440	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
THEBR_RS11445	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
THEBR_RS11450	COG1527	subunit (C
THEBR_RS11455	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
THEBR_RS11460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THEBR_RS11465	COG1269	ATP hydrolysis coupled proton transport
THEBR_RS11485	COG0305	Participates in initiation and elongation during chromosome replication
THEBR_RS11495	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
THEBR_RS11515	COG0629	single-stranded DNA binding
THEBR_RS11525	COG4481	Protein conserved in bacteria
THEBR_RS11530	COG0668	transmembrane transport
THEBR_RS11545	COG4242	Belongs to the peptidase S51 family
THEBR_RS11550	COG1597	lipid kinase activity
THEBR_RS11560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THEBR_RS11565	COG1475	DNA binding
THEBR_RS11570	COG1192	Involved in chromosome partitioning
THEBR_RS11575	COG1475	DNA binding
THEBR_RS11585	COG0357	Ribosomal RNA small subunit methyltransferase G
THEBR_RS11595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THEBR_RS11600	COG1847	R3H domain protein
THEBR_RS11605	COG0706	membrane insertase activity
THEBR_RS11650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component