locus-tag	class	description
THIT_RS00010	COG0592	DNA-directed DNA polymerase activity
THIT_RS00015	COG2501	S4 domain
THIT_RS00035	COG3442	glutamine amidotransferase
THIT_RS00045	COG0187	DNA topoisomerase II activity
THIT_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THIT_RS00055	COG1902	pentaerythritol trinitrate reductase activity
THIT_RS00060	COG0440	acetolactate synthase activity
THIT_RS00070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THIT_RS00080	COG0066	3-isopropylmalate dehydratase activity
THIT_RS00085	COG0473	3-isopropylmalate dehydrogenase activity
THIT_RS00090	COG0129	dihydroxy-acid dehydratase activity
THIT_RS00095	COG0028	Belongs to the TPP enzyme family
THIT_RS00120	COG0628	permease
THIT_RS00145	COG1316	TRANSCRIPTIONal
THIT_RS00150	COG1615	UPF0182 protein
THIT_RS00180	COG2199	diguanylate cyclase activity
THIT_RS00180	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THIT_RS00185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THIT_RS00190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THIT_RS00195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THIT_RS00200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THIT_RS00205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THIT_RS00210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THIT_RS00255	COG1028	Short-chain dehydrogenase reductase Sdr
THIT_RS00260	COG1187	pseudouridine synthase activity
THIT_RS00265	COG1609	Transcriptional regulator
THIT_RS00270	COG4166	transmembrane transport
THIT_RS00275	COG0601	transmembrane transport
THIT_RS00285	COG0444	Belongs to the ABC transporter superfamily
THIT_RS00290	COG4608	Belongs to the ABC transporter superfamily
THIT_RS00300	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THIT_RS00305	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THIT_RS00310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THIT_RS00325	COG1181	Belongs to the D-alanine--D-alanine ligase family
THIT_RS00330	COG1028	Short-chain dehydrogenase reductase Sdr
THIT_RS00340	COG1511	domain protein
THIT_RS00360	COG1573	uracil-dna glycosylase
THIT_RS00375	COG3829	transcription factor binding
THIT_RS00425	COG2391	methyltransferase activity
THIT_RS00435	COG2391	methyltransferase activity
THIT_RS00445	COG3344	reverse transcriptase
THIT_RS00455	COG0519	Catalyzes the synthesis of GMP from XMP
THIT_RS00465	COG1982	Orn Lys Arg decarboxylase major
THIT_RS00475	COG3870	Protein conserved in bacteria
THIT_RS00485	COG0470	DNA polymerase III
THIT_RS00490	COG1774	PSP1 C-terminal conserved region
THIT_RS00495	COG2235	arginine
THIT_RS00500	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
THIT_RS00505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THIT_RS00515	COG2002	toxin-antitoxin pair type II binding
THIT_RS00520	COG2715	membrane protein required for spore maturation
THIT_RS00525	COG0700	Nucleoside recognition
THIT_RS00530	COG0617	tRNA 3'-terminal CCA addition
THIT_RS00535	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIT_RS00535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIT_RS00540	COG0084	hydrolase, TatD family'
THIT_RS00545	COG3584	3D domain protein
THIT_RS00545	COG3583	domain protein
THIT_RS00550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THIT_RS00560	COG3344	reverse transcriptase
THIT_RS00575	COG4447	cellulose binding
THIT_RS00580	COG1191	sigma factor activity
THIT_RS00585	COG2151	metal-sulfur cluster biosynthetic enzyme
THIT_RS00585	COG0489	protein tyrosine kinase activity
THIT_RS00600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THIT_RS00605	COG4656	Part of a membrane complex involved in electron transport
THIT_RS00610	COG4658	electron transport chain
THIT_RS00615	COG4659	FMN binding
THIT_RS00620	COG4660	Part of a membrane complex involved in electron transport
THIT_RS00625	COG4657	Part of a membrane complex involved in electron transport
THIT_RS00630	COG2878	Part of a membrane complex involved in electron transport
THIT_RS00630	COG1245	4Fe-4S binding domain
THIT_RS00645	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THIT_RS00660	COG3872	metal-dependent enzyme
THIT_RS00670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THIT_RS00675	COG0428	transporter
THIT_RS00680	COG0009	L-threonylcarbamoyladenylate synthase
THIT_RS00685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THIT_RS00690	COG0698	ribose 5-phosphate isomerase
THIT_RS00705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THIT_RS00710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THIT_RS00725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THIT_RS00730	COG0686	Belongs to the AlaDH PNT family
THIT_RS00740	COG2385	sporulation resulting in formation of a cellular spore
THIT_RS00750	COG1609	Transcriptional regulator
THIT_RS00755	COG1077	Cell shape determining protein MreB Mrl
THIT_RS00760	COG4786	Flagellar basal body rod
THIT_RS00775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THIT_RS00790	COG1496	oxidoreductase activity
THIT_RS00805	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THIT_RS00805	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THIT_RS00810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS00810	COG2213	PTS system mannitol-specific
THIT_RS00815	COG3414	Phosphotransferase system galactitol-specific IIB component
THIT_RS00820	COG3775	system Galactitol-specific IIC component
THIT_RS00840	COG4948	Mandelate Racemase Muconate Lactonizing
THIT_RS00845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THIT_RS00850	COG0800	Aldolase
THIT_RS00860	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THIT_RS00860	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THIT_RS00865	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS00875	COG3716	PTS system mannose fructose sorbose family IID component
THIT_RS00880	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THIT_RS00885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THIT_RS00890	COG0800	Aldolase
THIT_RS00895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THIT_RS00900	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THIT_RS00905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THIT_RS00910	COG0569	domain protein
THIT_RS00915	COG2115	Belongs to the xylose isomerase family
THIT_RS00920	COG1070	Carbohydrate kinase
THIT_RS00925	COG0673	inositol 2-dehydrogenase activity
THIT_RS00935	COG1904	glucuronate isomerase
THIT_RS00940	COG0800	Aldolase
THIT_RS00945	COG0246	Mannitol dehydrogenase
THIT_RS00950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THIT_RS00955	COG1312	Catalyzes the dehydration of D-mannonate
THIT_RS00960	COG4209	transmembrane transport
THIT_RS00965	COG0395	ABC-type sugar transport system, permease component
THIT_RS00990	COG3458	cephalosporin-C deacetylase activity
THIT_RS01015	COG0395	ABC-type sugar transport system, permease component
THIT_RS01020	COG1472	Belongs to the glycosyl hydrolase 3 family
THIT_RS01030	COG1472	Belongs to the glycosyl hydrolase 3 family
THIT_RS01045	COG0436	Aminotransferase
THIT_RS01050	COG1522	sequence-specific DNA binding
THIT_RS01060	COG1918	ferrous iron import across plasma membrane
THIT_RS01060	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THIT_RS01070	COG1122	ATPase activity
THIT_RS01075	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THIT_RS01080	COG0310	cobalt ion transport
THIT_RS01085	COG0310	cobalt ion transport
THIT_RS01090	COG0864	Transcriptional regulator
THIT_RS01100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THIT_RS01105	COG0534	Mate efflux family protein
THIT_RS01110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THIT_RS01115	COG1136	(ABC) transporter
THIT_RS01120	COG0577	efflux transmembrane transporter activity
THIT_RS01120	COG1136	(ABC) transporter
THIT_RS01130	COG2703	oxygen carrier activity
THIT_RS01135	COG0179	Fumarylacetoacetate (FAA) hydrolase
THIT_RS01145	COG1074	ATP-dependent DNA helicase activity
THIT_RS01150	COG0420	3'-5' exonuclease activity
THIT_RS01155	COG0419	ATPase involved in DNA repair
THIT_RS01160	COG0450	alkyl hydroperoxide reductase
THIT_RS01190	COG0297	glycogen (starch) synthase activity
THIT_RS01195	COG3464	Transposase
THIT_RS01200	COG0586	Pfam SNARE associated Golgi protein
THIT_RS01225	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
THIT_RS01225	COG0493	'glutamate synthase
THIT_RS01240	COG3275	phosphorelay sensor kinase activity
THIT_RS01245	COG2197	response regulator
THIT_RS01250	COG4213	ABC transporter substrate-binding protein
THIT_RS01255	COG4213	ABC transporter substrate-binding protein
THIT_RS01265	COG4214	carbohydrate transport
THIT_RS01270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THIT_RS01275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THIT_RS01290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THIT_RS01295	COG0095	Lipoate-protein ligase
THIT_RS01300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THIT_RS01315	COG0436	Aminotransferase
THIT_RS01320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS01320	COG3711	transcriptional antiterminator
THIT_RS01330	COG0205	6-phosphofructokinase activity
THIT_RS01355	COG0191	fructose-bisphosphate aldolase activity
THIT_RS01375	COG3464	Transposase
THIT_RS01385	COG3464	Transposase
THIT_RS01390	COG1979	alcohol dehydrogenase
THIT_RS01405	COG1309	transcriptional regulator
THIT_RS01420	COG1924	4 iron, 4 sulfur cluster binding
THIT_RS01430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THIT_RS01435	COG0390	transport system, permease component
THIT_RS01440	COG0823	Involved in the tonB-independent uptake of proteins
THIT_RS01450	COG0495	leucyl-tRNA aminoacylation
THIT_RS01455	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
THIT_RS01475	COG1522	sequence-specific DNA binding
THIT_RS01475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THIT_RS01480	COG2313	pseudouridylate synthase activity
THIT_RS01490	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THIT_RS01490	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THIT_RS01500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THIT_RS01505	COG1447	Phosphotransferase system cellobiose-specific component IIA
THIT_RS01510	COG1486	melibiose metabolic process
THIT_RS01515	COG0561	phosphatase activity
THIT_RS01520	COG2723	6-phospho-beta-galactosidase activity
THIT_RS01530	COG1486	melibiose metabolic process
THIT_RS01535	COG2213	PTS system mannitol-specific
THIT_RS01540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS01540	COG3711	transcriptional antiterminator
THIT_RS01555	COG0737	Belongs to the 5'-nucleotidase family
THIT_RS01560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THIT_RS01565	COG0730	response to heat
THIT_RS01585	COG4166	transmembrane transport
THIT_RS01590	COG0601	transmembrane transport
THIT_RS01595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THIT_RS01600	COG0444	Belongs to the ABC transporter superfamily
THIT_RS01610	COG3250	beta-galactosidase activity
THIT_RS01615	COG2723	6-phospho-beta-galactosidase activity
THIT_RS01620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THIT_RS01625	COG1121	(ABC) transporter
THIT_RS01630	COG0803	Belongs to the bacterial solute-binding protein 9 family
THIT_RS01635	COG0735	belongs to the Fur family
THIT_RS01640	COG0714	Associated with various cellular activities
THIT_RS01655	COG1704	LemA family
THIT_RS01660	COG0583	DNA-binding transcription factor activity
THIT_RS01680	COG0084	hydrolase, TatD family'
THIT_RS01695	COG0822	iron-sulfur transferase activity
THIT_RS01710	COG0116	Belongs to the methyltransferase superfamily
THIT_RS01715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THIT_RS01720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THIT_RS01725	COG1120	ATPase activity
THIT_RS01730	COG1797	cobyrinic acid a,c-diamide synthase activity
THIT_RS01755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THIT_RS01820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THIT_RS01825	COG0181	hydroxymethylbilane synthase activity
THIT_RS01835	COG0113	porphobilinogen synthase activity
THIT_RS01840	COG1648	precorrin-2 dehydrogenase activity
THIT_RS01840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THIT_RS01855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THIT_RS01860	COG0310	cobalt ion transport
THIT_RS01875	COG1122	ATPase activity
THIT_RS01925	COG4555	ABC transporter
THIT_RS01955	COG2814	Major facilitator Superfamily
THIT_RS01985	COG1131	(ABC) transporter
THIT_RS01995	COG4566	intracellular signal transduction
THIT_RS02025	COG1132	(ABC) transporter
THIT_RS02035	COG1136	(ABC) transporter
THIT_RS02050	COG1363	Peptidase, m42
THIT_RS02075	COG2199	diguanylate cyclase activity
THIT_RS02075	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THIT_RS02085	COG0840	transmembrane signaling receptor activity
THIT_RS02095	COG1228	amidohydrolase
THIT_RS02105	COG0366	Alpha amylase catalytic
THIT_RS02120	COG1653	transport
THIT_RS02125	COG2972	Histidine kinase
THIT_RS02130	COG4753	response regulator
THIT_RS02130	COG2207	Transcriptional regulator
THIT_RS02135	COG3404	Formiminotransferase-cyclodeaminase
THIT_RS02140	COG1744	ABC transporter substrate-binding protein PnrA-like
THIT_RS02145	COG3845	ABC transporter
THIT_RS02150	COG4603	Belongs to the binding-protein-dependent transport system permease family
THIT_RS02155	COG1079	Belongs to the binding-protein-dependent transport system permease family
THIT_RS02160	COG2188	Transcriptional regulator
THIT_RS02180	COG0840	transmembrane signaling receptor activity
THIT_RS02190	COG1263	PTS System
THIT_RS02190	COG2190	(PTS) system
THIT_RS02190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THIT_RS02195	COG2190	(PTS) system
THIT_RS02200	COG3711	transcriptional antiterminator
THIT_RS02205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THIT_RS02235	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
THIT_RS02245	COG2323	membrane
THIT_RS02250	COG0561	phosphatase activity
THIT_RS02255	COG1609	Transcriptional regulator
THIT_RS02260	COG0745	RESPONSE REGULATOR receiver
THIT_RS02265	COG5002	protein histidine kinase activity
THIT_RS02305	COG1592	Rubrerythrin
THIT_RS02310	COG2104	thiamine diphosphate biosynthetic process
THIT_RS02315	COG0037	tRNA processing
THIT_RS02320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THIT_RS02325	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THIT_RS02330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THIT_RS02335	COG1040	competence protein
THIT_RS02355	COG1256	bacterial-type flagellum assembly
THIT_RS02355	COG4786	Flagellar basal body rod
THIT_RS02360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THIT_RS02370	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
THIT_RS02375	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THIT_RS02380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THIT_RS02390	COG2604	Protein of unknown function DUF115
THIT_RS02395	COG1086	Polysaccharide biosynthesis protein
THIT_RS02400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THIT_RS02405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THIT_RS02410	COG2089	acid synthase
THIT_RS02420	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THIT_RS02420	COG0517	IMP dehydrogenase activity
THIT_RS02445	COG0367	asparagine synthase
THIT_RS02460	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THIT_RS02465	COG1516	flagellar protein fliS
THIT_RS02475	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THIT_RS02475	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THIT_RS02480	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS02480	COG2213	PTS system mannitol-specific
THIT_RS02485	COG3414	Phosphotransferase system galactitol-specific IIB component
THIT_RS02490	COG3775	system Galactitol-specific IIC component
THIT_RS02495	COG1105	Belongs to the carbohydrate kinase PfkB family
THIT_RS02525	COG0840	transmembrane signaling receptor activity
THIT_RS02535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THIT_RS02540	COG0765	amino acid transport
THIT_RS02570	COG1827	regulation of RNA biosynthetic process
THIT_RS02580	COG0653	protein targeting
THIT_RS02585	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THIT_RS02590	COG2183	response to ionizing radiation
THIT_RS02605	COG3711	transcriptional antiterminator
THIT_RS02605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS02610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THIT_RS02610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THIT_RS02610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS02615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS02615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THIT_RS02615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THIT_RS02620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THIT_RS02625	COG0383	alpha-mannosidase activity
THIT_RS02630	COG0398	Pfam SNARE associated Golgi protein
THIT_RS02640	COG2814	Major facilitator Superfamily
THIT_RS02645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THIT_RS02665	COG0802	atpase or kinase
THIT_RS02670	COG1214	PFAM Peptidase M22, glycoprotease
THIT_RS02680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THIT_RS02690	COG0488	(ABC) transporter
THIT_RS02695	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THIT_RS02715	COG3279	Response regulator of the LytR AlgR family
THIT_RS02720	COG3290	protein histidine kinase activity
THIT_RS02740	COG0493	'glutamate synthase
THIT_RS02755	COG1811	Na channel or pump
THIT_RS02765	COG1404	Belongs to the peptidase S8 family
THIT_RS02775	COG3344	reverse transcriptase
THIT_RS02805	COG0516	GMP reductase activity
THIT_RS02805	COG0517	IMP dehydrogenase activity
THIT_RS02810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THIT_RS02810	COG0519	Catalyzes the synthesis of GMP from XMP
THIT_RS02815	COG2252	PERMEase
THIT_RS02820	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THIT_RS02830	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THIT_RS02835	COG0047	phosphoribosylformylglycinamidine synthase activity
THIT_RS02840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THIT_RS02845	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THIT_RS02855	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THIT_RS02860	COG0138	bifunctional purine biosynthesis protein purh
THIT_RS02865	COG0151	Belongs to the GarS family
THIT_RS02875	COG1473	amidohydrolase
THIT_RS02885	COG2244	polysaccharide biosynthetic process
THIT_RS02895	COG3711	transcriptional antiterminator
THIT_RS02905	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THIT_RS02910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THIT_RS02915	COG1447	Phosphotransferase system cellobiose-specific component IIA
THIT_RS02920	COG4496	protein, YerC YecD
THIT_RS02925	COG0210	DNA helicase
THIT_RS02945	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THIT_RS02955	COG0860	N-Acetylmuramoyl-L-alanine amidase
THIT_RS02955	COG2247	cell wall binding repeat
THIT_RS03025	COG0351	phosphomethylpyrimidine kinase
THIT_RS03030	COG0352	thiamine-phosphate diphosphorylase activity
THIT_RS03040	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
THIT_RS03050	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
THIT_RS03055	COG0704	Plays a role in the regulation of phosphate uptake
THIT_RS03090	COG3706	GGDEF domain
THIT_RS03115	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THIT_RS03120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THIT_RS03130	COG0356	it plays a direct role in the translocation of protons across the membrane
THIT_RS03135	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THIT_RS03140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THIT_RS03145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THIT_RS03150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THIT_RS03155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THIT_RS03160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THIT_RS03165	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THIT_RS03175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THIT_RS03175	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THIT_RS03180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THIT_RS03185	COG1116	anion transmembrane transporter activity
THIT_RS03205	COG2239	Acts as a magnesium transporter
THIT_RS03225	COG0840	transmembrane signaling receptor activity
THIT_RS03225	COG3290	protein histidine kinase activity
THIT_RS03245	COG0438	transferase activity, transferring glycosyl groups
THIT_RS03250	COG1215	transferase activity, transferring glycosyl groups
THIT_RS03255	COG2244	polysaccharide biosynthetic process
THIT_RS03265	COG2244	polysaccharide biosynthetic process
THIT_RS03270	COG0562	UDP-galactopyranose mutase
THIT_RS03280	COG0297	glycogen (starch) synthase activity
THIT_RS03295	COG1091	dTDP-4-dehydrorhamnose reductase activity
THIT_RS03305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THIT_RS03330	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THIT_RS03335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THIT_RS03415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THIT_RS03420	COG0622	Phosphoesterase
THIT_RS03430	COG1914	H( )-stimulated, divalent metal cation uptake system
THIT_RS03440	COG1598	PFAM Uncharacterised protein family UPF0150
THIT_RS03520	COG0667	Aldo Keto reductase
THIT_RS03525	COG1979	alcohol dehydrogenase
THIT_RS03530	COG0656	L-ascorbic acid biosynthetic process
THIT_RS03550	COG0789	Transcriptional regulator
THIT_RS03560	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THIT_RS03575	COG0250	Participates in transcription elongation, termination and antitermination
THIT_RS03585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THIT_RS03590	COG3944	biosynthesis protein
THIT_RS03595	COG3949	Membrane
THIT_RS03605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THIT_RS03615	COG2814	Major facilitator Superfamily
THIT_RS03640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THIT_RS03645	COG1606	tRNA processing
THIT_RS03650	COG1691	(AIR) carboxylase
THIT_RS03655	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THIT_RS03660	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THIT_RS03665	COG5002	protein histidine kinase activity
THIT_RS03670	COG0745	RESPONSE REGULATOR receiver
THIT_RS03690	COG0525	valine-tRNA ligase activity
THIT_RS03700	COG0285	dihydrofolate synthase activity
THIT_RS03710	COG3464	Transposase
THIT_RS03755	COG3344	reverse transcriptase
THIT_RS03765	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THIT_RS03770	COG1609	Transcriptional regulator
THIT_RS03785	COG1175	transmembrane transport
THIT_RS03790	COG0395	ABC-type sugar transport system, permease component
THIT_RS03795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THIT_RS03815	COG0395	ABC-type sugar transport system, permease component
THIT_RS03830	COG1404	Belongs to the peptidase S8 family
THIT_RS03855	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THIT_RS03855	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THIT_RS03860	COG3773	Cell wall hydrolase
THIT_RS03860	COG3409	Peptidoglycan-binding domain 1 protein
THIT_RS03885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THIT_RS03895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THIT_RS03905	COG1132	(ABC) transporter
THIT_RS03910	COG1132	(ABC) transporter
THIT_RS03935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
THIT_RS03940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THIT_RS03950	COG0739	heme binding
THIT_RS03975	COG0616	signal peptide processing
THIT_RS03990	COG4475	Protein of unknown function (DUF436)
THIT_RS04010	COG1131	(ABC) transporter
THIT_RS04040	COG1113	amino acid transport
THIT_RS04045	COG1595	DNA-templated transcription, initiation
THIT_RS04055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THIT_RS04055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THIT_RS04060	COG0237	dephospho-CoA kinase activity
THIT_RS04065	COG0741	lytic transglycosylase activity
THIT_RS04090	COG0791	NLP P60 protein
THIT_RS04095	COG1217	gtp-binding protein TYPA
THIT_RS04100	COG0741	lytic transglycosylase activity
THIT_RS04120	COG2878	Part of a membrane complex involved in electron transport
THIT_RS04140	COG4191	Histidine kinase
THIT_RS04140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THIT_RS04170	COG2003	Belongs to the UPF0758 family
THIT_RS04175	COG1077	Cell shape determining protein MreB Mrl
THIT_RS04190	COG0768	penicillin binding
THIT_RS04200	COG2894	cell division
THIT_RS04210	COG0772	Belongs to the SEDS family
THIT_RS04220	COG0739	heme binding
THIT_RS04225	COG0517	IMP dehydrogenase activity
THIT_RS04225	COG1994	Peptidase M50
THIT_RS04240	COG1530	ribonuclease E activity
THIT_RS04255	COG5416	Lipopolysaccharide assembly protein A domain
THIT_RS04290	COG1713	HD superfamily hydrolase involved in NAD metabolism
THIT_RS04295	COG1316	TRANSCRIPTIONal
THIT_RS04300	COG0799	negative regulation of ribosome biogenesis
THIT_RS04320	COG0367	asparagine synthase
THIT_RS04325	COG1686	Belongs to the peptidase S11 family
THIT_RS04330	COG1555	photosystem II stabilization
THIT_RS04330	COG1596	polysaccharide export
THIT_RS04340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THIT_RS04375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THIT_RS04390	COG4720	Psort location CytoplasmicMembrane, score
THIT_RS04395	COG0546	phosphoglycolate phosphatase activity
THIT_RS04400	COG1234	tRNA 3'-trailer cleavage
THIT_RS04405	COG2333	competence protein COMEC
THIT_RS04405	COG0658	competence protein
THIT_RS04415	COG0268	Binds directly to 16S ribosomal RNA
THIT_RS04420	COG1297	OPT oligopeptide transporter protein
THIT_RS04435	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THIT_RS04460	COG0481	GTPase activity
THIT_RS04465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THIT_RS04475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THIT_RS04485	COG0484	heat shock protein binding
THIT_RS04495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THIT_RS04500	COG3830	Belongs to the UPF0237 family
THIT_RS04515	COG0701	Predicted permease
THIT_RS04535	COG0745	RESPONSE REGULATOR receiver
THIT_RS04540	COG2205	protein histidine kinase activity
THIT_RS04540	COG2770	Histidine kinase
THIT_RS04545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THIT_RS04560	COG2246	polysaccharide biosynthetic process
THIT_RS04570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THIT_RS04575	COG0537	adenosine 5'-monophosphoramidase activity
THIT_RS04600	COG1702	phosphate starvation-inducible protein PhoH
THIT_RS04605	COG1480	7TM receptor with intracellular HD hydrolase
THIT_RS04615	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THIT_RS04625	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
THIT_RS04640	COG0423	glycine-tRNA ligase activity
THIT_RS04650	COG0574	Belongs to the PEP-utilizing enzyme family
THIT_RS04650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THIT_RS04660	COG0557	exoribonuclease II activity
THIT_RS04700	COG0602	queuosine metabolic process
THIT_RS04705	COG4555	ABC transporter
THIT_RS04745	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
THIT_RS04755	COG0693	protein deglycase activity
THIT_RS04785	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THIT_RS04805	COG3069	C4-dicarboxylate transmembrane transporter activity
THIT_RS04815	COG0426	domain, Protein
THIT_RS04820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THIT_RS04830	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
THIT_RS04835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THIT_RS04840	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
THIT_RS04855	COG1760	l-serine dehydratase
THIT_RS04860	COG1164	Oligoendopeptidase f
THIT_RS04870	COG0077	Prephenate dehydratase
THIT_RS04870	COG1605	Chorismate mutase
THIT_RS04875	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THIT_RS04880	COG0287	Prephenate dehydrogenase
THIT_RS04895	COG2119	membrane
THIT_RS04910	COG0745	RESPONSE REGULATOR receiver
THIT_RS04915	COG2205	protein histidine kinase activity
THIT_RS04925	COG1940	carbohydrate kinase activity
THIT_RS04930	COG0363	glucosamine-6-phosphate deaminase activity
THIT_RS04940	COG0785	Cytochrome C biogenesis protein
THIT_RS04945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIT_RS04950	COG1982	Orn Lys Arg decarboxylase major
THIT_RS04975	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THIT_RS04990	COG1739	Uncharacterized protein family UPF0029
THIT_RS05010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THIT_RS05020	COG0835	chemotaxis
THIT_RS05030	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THIT_RS05050	COG2385	sporulation resulting in formation of a cellular spore
THIT_RS05050	COG2247	cell wall binding repeat
THIT_RS05060	COG0343	queuine tRNA-ribosyltransferase activity
THIT_RS05080	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THIT_RS05085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THIT_RS05090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THIT_RS05100	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THIT_RS05100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THIT_RS05110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THIT_RS05115	COG1490	D-aminoacyl-tRNA deacylase activity
THIT_RS05120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THIT_RS05125	COG0577	efflux transmembrane transporter activity
THIT_RS05130	COG1136	(ABC) transporter
THIT_RS05135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THIT_RS05145	COG3464	Transposase
THIT_RS05150	COG3328	transposase activity
THIT_RS05155	COG3464	Transposase
THIT_RS05165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THIT_RS05170	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THIT_RS05175	COG1937	Protein conserved in bacteria
THIT_RS05180	COG3118	belongs to the thioredoxin family
THIT_RS05185	COG3457	Alanine racemase
THIT_RS05190	COG1959	2 iron, 2 sulfur cluster binding
THIT_RS05205	COG4472	Bacterial protein of unknown function (DUF965)
THIT_RS05210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THIT_RS05215	COG3906	Belongs to the UPF0473 family
THIT_RS05220	COG0735	belongs to the Fur family
THIT_RS05225	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
THIT_RS05230	COG3679	Belongs to the UPF0342 family
THIT_RS05240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THIT_RS05245	COG4122	O-methyltransferase activity
THIT_RS05250	COG0826	peptidase U32
THIT_RS05255	COG0768	penicillin binding
THIT_RS05265	COG0546	phosphoglycolate phosphatase activity
THIT_RS05270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THIT_RS05275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THIT_RS05285	COG1459	type II secretion system
THIT_RS05295	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THIT_RS05355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THIT_RS05365	COG0006	proline dipeptidase activity
THIT_RS05380	COG3854	ATPases associated with a variety of cellular activities
THIT_RS05420	COG1302	Protein conserved in bacteria
THIT_RS05430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THIT_RS05435	COG1570	exodeoxyribonuclease VII activity
THIT_RS05455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THIT_RS05460	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
THIT_RS05470	COG1438	arginine binding
THIT_RS05475	COG0497	DNA recombination
THIT_RS05480	COG0750	zinc metalloprotease
THIT_RS05520	COG1379	DNA repair
THIT_RS05525	COG1300	Membrane
THIT_RS05530	COG4974	Belongs to the 'phage' integrase family
THIT_RS05535	COG1686	Belongs to the peptidase S11 family
THIT_RS05540	COG1366	Belongs to the anti-sigma-factor antagonist family
THIT_RS05555	COG3360	Dodecin
THIT_RS05575	COG0617	tRNA 3'-terminal CCA addition
THIT_RS05580	COG1994	Peptidase M50
THIT_RS05590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THIT_RS05595	COG4086	secreted protein
THIT_RS05605	COG3874	Sporulation protein YtfJ
THIT_RS05610	COG1686	Belongs to the peptidase S11 family
THIT_RS05620	COG0445	tRNA wobble uridine modification
THIT_RS05625	COG1187	pseudouridine synthase activity
THIT_RS05640	COG0010	Belongs to the arginase family
THIT_RS05650	COG1705	Flagellar rod assembly protein muramidase FlgJ
THIT_RS05650	COG1388	LysM domain
THIT_RS05685	COG0406	alpha-ribazole phosphatase activity
THIT_RS05705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THIT_RS05730	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THIT_RS05740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THIT_RS05760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THIT_RS05770	COG4974	Belongs to the 'phage' integrase family
THIT_RS05775	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
THIT_RS05780	COG0464	growth
THIT_RS05785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THIT_RS05795	COG0613	PHP domain protein
THIT_RS05800	COG2359	stage V sporulation protein S
THIT_RS05805	COG1692	metallophosphoesterase
THIT_RS05810	COG1418	mRNA catabolic process
THIT_RS05815	COG2137	regulation of response to DNA damage stimulus
THIT_RS05820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THIT_RS05825	COG1546	Belongs to the CinA family
THIT_RS05825	COG1058	Belongs to the CinA family
THIT_RS05830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THIT_RS05835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THIT_RS05840	COG1674	ftsk spoiiie
THIT_RS05850	COG0740	serine-type endopeptidase activity
THIT_RS05855	COG0527	aspartate kinase activity
THIT_RS05870	COG0612	Peptidase, M16
THIT_RS05880	COG0726	polysaccharide deacetylase
THIT_RS05885	COG1185	polyribonucleotide nucleotidyltransferase activity
THIT_RS05895	COG0196	riboflavin kinase activity
THIT_RS05900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THIT_RS05905	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THIT_RS05910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THIT_RS05915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THIT_RS05925	COG2740	Nucleic-acid-binding protein implicated in transcription termination
THIT_RS05930	COG0195	Participates in both transcription termination and antitermination
THIT_RS05940	COG2176	DNA-directed DNA polymerase activity
THIT_RS05950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THIT_RS05955	COG0750	zinc metalloprotease
THIT_RS05960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THIT_RS05965	COG4589	Belongs to the CDS family
THIT_RS05970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THIT_RS05980	COG0233	cytoplasmic translational termination
THIT_RS05985	COG0528	UMP kinase activity
THIT_RS06010	COG1191	sigma factor activity
THIT_RS06015	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THIT_RS06020	COG1776	CheC inhibitor of MCP methylation
THIT_RS06025	COG0835	chemotaxis
THIT_RS06030	COG2198	Histidine kinase
THIT_RS06030	COG0643	Histidine kinase
THIT_RS06035	COG2201	protein-glutamate methylesterase activity
THIT_RS06045	COG0455	bacterial-type flagellum organization
THIT_RS06050	COG1419	protein localization to endoplasmic reticulum
THIT_RS06055	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THIT_RS06060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THIT_RS06065	COG1684	flagellar biosynthetic protein fliR
THIT_RS06070	COG1987	bacterial-type flagellum assembly
THIT_RS06075	COG1338	Plays a role in the flagellum-specific transport system
THIT_RS06085	COG2201	protein-glutamate methylesterase activity
THIT_RS06090	COG1776	CheC inhibitor of MCP methylation
THIT_RS06090	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THIT_RS06095	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THIT_RS06100	COG1580	Controls the rotational direction of flagella during chemotaxis
THIT_RS06105	COG1582	Flagellar protein (FlbD)
THIT_RS06120	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THIT_RS06140	COG1157	protein secretion by the type III secretion system
THIT_RS06150	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THIT_RS06160	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THIT_RS06165	COG1766	The M ring may be actively involved in energy transduction
THIT_RS06170	COG1677	Flagellar hook-basal body complex protein FliE
THIT_RS06180	COG1815	bacterial-type flagellum-dependent cell motility
THIT_RS06195	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THIT_RS06200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THIT_RS06205	COG0758	DNA mediated transformation
THIT_RS06210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THIT_RS06215	COG0792	nuclease activity
THIT_RS06220	COG0180	Tryptophanyl-tRNA synthetase
THIT_RS06225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THIT_RS06230	COG0606	chelatase, subunit chli
THIT_RS06245	COG0336	Belongs to the RNA methyltransferase TrmD family
THIT_RS06255	COG1837	Belongs to the UPF0109 family
THIT_RS06260	COG0228	four-way junction DNA binding
THIT_RS06265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THIT_RS06270	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
THIT_RS06275	COG0552	protein localization to endoplasmic reticulum
THIT_RS06290	COG2359	stage V sporulation protein S
THIT_RS06305	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
THIT_RS06310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THIT_RS06325	COG0437	4 iron, 4 sulfur cluster binding
THIT_RS06335	COG0067	glutamate synthase
THIT_RS06340	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THIT_RS06345	COG0347	Belongs to the P(II) protein family
THIT_RS06350	COG0004	ammonium transporteR
THIT_RS06360	COG0571	ribonuclease III activity
THIT_RS06365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THIT_RS06375	COG1028	Short-chain dehydrogenase reductase Sdr
THIT_RS06380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THIT_RS06385	COG2070	2-Nitropropane dioxygenase
THIT_RS06390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THIT_RS06395	COG0416	fatty acid biosynthetic process
THIT_RS06405	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THIT_RS06410	COG1399	metal-binding, possibly nucleic acid-binding protein
THIT_RS06415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THIT_RS06420	COG0280	phosphate acetyltransferase
THIT_RS06430	COG3314	Sporulation integral membrane protein YlbJ
THIT_RS06445	COG0742	ribosomal rna small subunit methyltransferase
THIT_RS06460	COG1307	EDD domain protein, DegV family
THIT_RS06465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THIT_RS06470	COG1461	Dihydroxyacetone kinase
THIT_RS06475	COG1302	Protein conserved in bacteria
THIT_RS06495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THIT_RS06500	COG1162	GTPase activity
THIT_RS06505	COG2815	serine threonine protein kinase
THIT_RS06505	COG0515	serine threonine protein kinase
THIT_RS06510	COG0631	protein serine/threonine phosphatase activity
THIT_RS06520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THIT_RS06520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THIT_RS06525	COG2738	Putative neutral zinc metallopeptidase
THIT_RS06535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THIT_RS06540	COG0242	peptide deformylase activity
THIT_RS06550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THIT_RS06555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THIT_RS06565	COG0194	GDP metabolic process
THIT_RS06575	COG1561	YicC-like family, N-terminal region
THIT_RS06580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THIT_RS06585	COG2814	Major facilitator Superfamily
THIT_RS06605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
THIT_RS06610	COG2011	ABC-type metal ion transport system permease component
THIT_RS06615	COG1464	Belongs to the NlpA lipoprotein family
THIT_RS06635	COG0037	tRNA processing
THIT_RS06660	COG0543	2 iron, 2 sulfur cluster binding
THIT_RS06665	COG0284	orotidine-5'-phosphate decarboxylase activity
THIT_RS06675	COG0540	Belongs to the ATCase OTCase family
THIT_RS06685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THIT_RS06690	COG0564	pseudouridine synthase activity
THIT_RS06695	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THIT_RS06750	COG1337	RAMP superfamily
THIT_RS06775	COG1970	mechanosensitive ion channel activity
THIT_RS06785	COG1595	DNA-templated transcription, initiation
THIT_RS06805	COG3344	reverse transcriptase
THIT_RS06820	COG3344	reverse transcriptase
THIT_RS06830	COG0860	N-Acetylmuramoyl-L-alanine amidase
THIT_RS06955	COG1783	phage Terminase large subunit
THIT_RS06990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THIT_RS07000	COG1484	DNA-dependent DNA replication
THIT_RS07010	COG3723	Recombinational DNA repair protein, rece pathway
THIT_RS07015	COG5377	YqaJ viral recombinase family
THIT_RS07040	COG1396	sequence-specific DNA binding
THIT_RS07060	COG1983	PspC domain protein
THIT_RS07080	COG0626	cystathionine gamma-synthase activity
THIT_RS07100	COG0134	indole-3-glycerol-phosphate synthase activity
THIT_RS07110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THIT_RS07110	COG0512	Glutamine amidotransferase of anthranilate synthase
THIT_RS07130	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THIT_RS07170	COG3599	regulation of cell shape
THIT_RS07175	COG2302	S4 RNA-binding domain
THIT_RS07190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THIT_RS07205	COG2610	gluconate transmembrane transporter activity
THIT_RS07210	COG1929	Belongs to the glycerate kinase type-1 family
THIT_RS07215	COG3835	regulator
THIT_RS07235	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
THIT_RS07245	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THIT_RS07250	COG1160	GTP binding
THIT_RS07290	COG0704	Plays a role in the regulation of phosphate uptake
THIT_RS07295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THIT_RS07300	COG0581	inorganic phosphate transmembrane transporter activity
THIT_RS07305	COG0573	inorganic phosphate transmembrane transporter activity
THIT_RS07310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THIT_RS07315	COG5002	protein histidine kinase activity
THIT_RS07320	COG0745	RESPONSE REGULATOR receiver
THIT_RS07330	COG1873	PFAM PRC-barrel domain
THIT_RS07335	COG1191	sigma factor activity
THIT_RS07340	COG1191	sigma factor activity
THIT_RS07350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THIT_RS07355	COG0849	cell division
THIT_RS07360	COG3856	small basic protein
THIT_RS07375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THIT_RS07385	COG0772	Belongs to the SEDS family
THIT_RS07400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THIT_RS07405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THIT_RS07410	COG0768	penicillin binding
THIT_RS07430	COG0612	Peptidase, M16
THIT_RS07435	COG0612	Peptidase, M16
THIT_RS07445	COG0012	GTP binding
THIT_RS07480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THIT_RS07485	COG0321	lipoyl(octanoyl) transferase activity
THIT_RS07490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THIT_RS07505	COG2340	Cysteine-rich secretory protein family
THIT_RS07510	COG1362	aminopeptidase activity
THIT_RS07515	COG2197	response regulator
THIT_RS07535	COG1683	Conserved Protein
THIT_RS07540	COG1193	negative regulation of DNA recombination
THIT_RS07545	COG0826	peptidase U32
THIT_RS07555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THIT_RS07555	COG0072	phenylalanine-tRNA ligase activity
THIT_RS07560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THIT_RS07565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THIT_RS07580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THIT_RS07595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THIT_RS07600	COG4399	Belongs to the UPF0754 family
THIT_RS07615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THIT_RS07650	COG1278	Cold shock
THIT_RS07655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THIT_RS07670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
THIT_RS07675	COG1956	GAF domain-containing protein
THIT_RS07700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THIT_RS07710	COG1482	cell wall glycoprotein biosynthetic process
THIT_RS07720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THIT_RS07735	COG2384	SAM-dependent methyltransferase
THIT_RS07750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THIT_RS07755	COG0358	DNA primase activity
THIT_RS07760	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THIT_RS07765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THIT_RS07770	COG3344	reverse transcriptase
THIT_RS07775	COG0148	phosphopyruvate hydratase activity
THIT_RS07780	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THIT_RS07785	COG0149	triose-phosphate isomerase activity
THIT_RS07790	COG0126	phosphoglycerate kinase activity
THIT_RS07800	COG2390	Transcriptional regulator
THIT_RS07805	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
THIT_RS07810	COG1254	Belongs to the acylphosphatase family
THIT_RS07815	COG0561	phosphatase activity
THIT_RS07825	COG2720	vancomycin resistance protein
THIT_RS07830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THIT_RS07835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THIT_RS07860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THIT_RS07865	COG1070	Carbohydrate kinase
THIT_RS07880	COG1012	belongs to the aldehyde dehydrogenase family
THIT_RS07895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THIT_RS07905	COG0613	PHP domain protein
THIT_RS07915	COG0698	ribose 5-phosphate isomerase
THIT_RS07920	COG3958	Transketolase
THIT_RS07925	COG3959	Transketolase, thiamine diphosphate binding domain
THIT_RS07930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THIT_RS07945	COG0564	pseudouridine synthase activity
THIT_RS07960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THIT_RS07965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THIT_RS07990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THIT_RS08000	COG3546	catalase activity
THIT_RS08005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
THIT_RS08010	COG1410	methionine synthase
THIT_RS08010	COG0646	methionine synthase
THIT_RS08015	COG0646	methionine synthase
THIT_RS08015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THIT_RS08020	COG0058	SHG alpha-glucan phosphorylase activity
THIT_RS08025	COG0166	Belongs to the GPI family
THIT_RS08030	COG0778	Nitroreductase
THIT_RS08035	COG2195	Cleaves the N-terminal amino acid of tripeptides
THIT_RS08045	COG0409	Hydrogenase expression formation protein
THIT_RS08050	COG0298	carbon dioxide binding
THIT_RS08055	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THIT_RS08065	COG0375	protein maturation
THIT_RS08085	COG3260	NADH ubiquinone oxidoreductase 20
THIT_RS08090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THIT_RS08095	COG2111	Na H antiporter
THIT_RS08095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THIT_RS08110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THIT_RS08120	COG1174	glycine betaine transport
THIT_RS08125	COG0517	IMP dehydrogenase activity
THIT_RS08125	COG1125	glycine betaine transport
THIT_RS08130	COG0471	metal ion transport
THIT_RS08130	COG3273	potassium ion transport
THIT_RS08135	COG0534	Mate efflux family protein
THIT_RS08145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THIT_RS08175	COG4109	DRTGG domain
THIT_RS08180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS08195	COG0366	Alpha amylase catalytic
THIT_RS08200	COG1426	Protein conserved in bacteria
THIT_RS08215	COG3833	ABC-type maltose transport systems, permease component
THIT_RS08220	COG1175	transmembrane transport
THIT_RS08225	COG2182	Extracellular solute-binding protein
THIT_RS08250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THIT_RS08270	COG2217	Heavy metal translocating P-type atpase
THIT_RS08275	COG0482	sulfurtransferase activity
THIT_RS08280	COG2608	mercury ion transmembrane transporter activity
THIT_RS08285	COG0586	Pfam SNARE associated Golgi protein
THIT_RS08290	COG1342	Belongs to the UPF0251 family
THIT_RS08310	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THIT_RS08310	COG2199	diguanylate cyclase activity
THIT_RS08320	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THIT_RS08320	COG1918	ferrous iron import across plasma membrane
THIT_RS08330	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THIT_RS08330	COG1918	ferrous iron import across plasma membrane
THIT_RS08355	COG1120	ATPase activity
THIT_RS08360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THIT_RS08365	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
THIT_RS08370	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIT_RS08375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THIT_RS08395	COG0489	protein tyrosine kinase activity
THIT_RS08400	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THIT_RS08425	COG1609	Transcriptional regulator
THIT_RS08430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THIT_RS08435	COG1621	beta-fructofuranosidase activity
THIT_RS08450	COG2182	Extracellular solute-binding protein
THIT_RS08470	COG0768	penicillin binding
THIT_RS08485	COG0371	Dehydrogenase
THIT_RS08490	COG1609	Transcriptional regulator
THIT_RS08495	COG0235	Class ii aldolase
THIT_RS08500	COG1069	ribulokinase activity
THIT_RS08505	COG2160	L-arabinose isomerase activity
THIT_RS08515	COG1172	Belongs to the binding-protein-dependent transport system permease family
THIT_RS08520	COG1129	ABC transporter
THIT_RS08535	COG0395	ABC-type sugar transport system, permease component
THIT_RS08540	COG1175	transmembrane transport
THIT_RS08545	COG1653	transport
THIT_RS08550	COG0383	alpha-mannosidase activity
THIT_RS08555	COG4977	sequence-specific DNA binding
THIT_RS08555	COG1917	Cupin 2, conserved barrel domain protein
THIT_RS08560	COG3250	beta-galactosidase activity
THIT_RS08590	COG1940	carbohydrate kinase activity
THIT_RS08595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THIT_RS08600	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THIT_RS08605	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
THIT_RS08630	COG0800	Aldolase
THIT_RS08635	COG0534	Mate efflux family protein
THIT_RS08640	COG1028	Short-chain dehydrogenase reductase Sdr
THIT_RS08645	COG1486	melibiose metabolic process
THIT_RS08650	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
THIT_RS08660	COG0395	ABC-type sugar transport system, permease component
THIT_RS08665	COG1175	transmembrane transport
THIT_RS08675	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
THIT_RS08680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THIT_RS08685	COG1904	glucuronate isomerase
THIT_RS08690	COG0246	Mannitol dehydrogenase
THIT_RS08695	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THIT_RS08700	COG1070	Carbohydrate kinase
THIT_RS08705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THIT_RS08715	COG1349	DNA-binding transcription factor activity
THIT_RS08720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THIT_RS08735	COG0673	inositol 2-dehydrogenase activity
THIT_RS08770	COG3885	ferrous iron binding
THIT_RS08770	COG2078	PFAM AMMECR1 domain protein
THIT_RS08780	COG0318	PFAM AMP-dependent synthetase and ligase
THIT_RS08810	COG0768	penicillin binding
THIT_RS08830	COG0556	nucleotide-excision repair
THIT_RS08835	COG2045	Belongs to the ComB family
THIT_RS08845	COG3409	Peptidoglycan-binding domain 1 protein
THIT_RS08845	COG0793	Belongs to the peptidase S41A family
THIT_RS08850	COG0739	heme binding
THIT_RS08855	COG2177	Part of the ABC transporter FtsEX involved in
THIT_RS08860	COG2884	Cell division ATP-binding protein ftsE
THIT_RS08865	COG3835	regulator
THIT_RS08870	COG3842	ATPase activity
THIT_RS08890	COG3344	reverse transcriptase
THIT_RS08910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THIT_RS08930	COG0849	cell division
THIT_RS08955	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
THIT_RS08955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS08955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THIT_RS08965	COG2376	Dihydroxyacetone kinase
THIT_RS08980	COG0446	pyridine nucleotide-disulphide oxidoreductase
THIT_RS08995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THIT_RS09000	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
THIT_RS09020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THIT_RS09030	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THIT_RS09035	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THIT_RS09050	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THIT_RS09050	COG0140	phosphoribosyl-ATP diphosphatase activity
THIT_RS09065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THIT_RS09070	COG0131	Imidazoleglycerol-phosphate dehydratase
THIT_RS09075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THIT_RS09080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THIT_RS09135	COG1131	(ABC) transporter
THIT_RS09140	COG3459	Glycosyltransferase 36 associated
THIT_RS09145	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
THIT_RS09145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THIT_RS09150	COG0673	inositol 2-dehydrogenase activity
THIT_RS09155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THIT_RS09160	COG2873	o-acetylhomoserine
THIT_RS09165	COG0460	homoserine dehydrogenase
THIT_RS09185	COG2197	response regulator
THIT_RS09225	COG3958	Transketolase
THIT_RS09230	COG3959	Transketolase, thiamine diphosphate binding domain
THIT_RS09235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THIT_RS09260	COG2337	Toxic component of a toxin-antitoxin (TA) module
THIT_RS09270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THIT_RS09280	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THIT_RS09280	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THIT_RS09325	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
THIT_RS09330	COG1793	dna ligase
THIT_RS09335	COG0432	Pfam Uncharacterised protein family UPF0047
THIT_RS09355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THIT_RS09395	COG1396	sequence-specific DNA binding
THIT_RS09400	COG4974	Belongs to the 'phage' integrase family
THIT_RS09405	COG3547	Transposase (IS116 IS110 IS902 family)
THIT_RS09430	COG3344	reverse transcriptase
THIT_RS09530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THIT_RS09550	COG0280	phosphate acetyltransferase
THIT_RS09580	COG3426	butyrate kinase activity
THIT_RS09590	COG0280	phosphate acetyltransferase
THIT_RS09595	COG3426	butyrate kinase activity
THIT_RS09605	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
THIT_RS09635	COG1388	LysM domain
THIT_RS09635	COG1705	Flagellar rod assembly protein muramidase FlgJ
THIT_RS09640	COG3344	reverse transcriptase
THIT_RS09665	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THIT_RS09675	COG1966	Carbon starvation protein
THIT_RS09755	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THIT_RS09760	COG1122	ATPase activity
THIT_RS09765	COG1122	ATPase activity
THIT_RS09795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THIT_RS09800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THIT_RS09820	COG0201	protein transport
THIT_RS09850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THIT_RS09880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THIT_RS09885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THIT_RS09925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THIT_RS09935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THIT_RS09950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THIT_RS09955	COG1358	cellular component organization or biogenesis
THIT_RS09960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THIT_RS09965	COG0085	RNA polymerase activity
THIT_RS09990	COG0250	Participates in transcription elongation, termination and antitermination
THIT_RS09995	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THIT_RS10000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THIT_RS10015	COG3688	RNA-binding protein containing a PIN domain
THIT_RS10020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THIT_RS10035	COG1045	serine acetyltransferase
THIT_RS10055	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THIT_RS10065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THIT_RS10070	COG4956	integral membrane protein (PIN domain superfamily)
THIT_RS10080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THIT_RS10085	COG1914	H( )-stimulated, divalent metal cation uptake system
THIT_RS10095	COG3833	ABC-type maltose transport systems, permease component
THIT_RS10100	COG1175	transmembrane transport
THIT_RS10105	COG2182	Extracellular solute-binding protein
THIT_RS10120	COG0542	response to heat
THIT_RS10125	COG3869	Catalyzes the specific phosphorylation of arginine residues in
THIT_RS10130	COG3880	PFAM UvrB UvrC protein
THIT_RS10145	COG0281	malic enzyme
THIT_RS10155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THIT_RS10160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THIT_RS10170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THIT_RS10175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS10175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THIT_RS10175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THIT_RS10180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THIT_RS10180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THIT_RS10180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS10185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS10185	COG3711	transcriptional antiterminator
THIT_RS10220	COG0823	Involved in the tonB-independent uptake of proteins
THIT_RS10220	COG1506	peptidase
THIT_RS10220	COG4946	Tricorn protease homolog
THIT_RS10230	COG0720	synthase
THIT_RS10235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THIT_RS10240	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THIT_RS10250	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THIT_RS10260	COG5322	oxidoreductase activity
THIT_RS10260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THIT_RS10285	COG0697	spore germination
THIT_RS10290	COG0531	amino acid
THIT_RS10300	COG4684	Psort location CytoplasmicMembrane, score
THIT_RS10305	COG4770	biotin carboxylase activity
THIT_RS10315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THIT_RS10325	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THIT_RS10330	COG3852	Histidine kinase
THIT_RS10340	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THIT_RS10345	COG0037	tRNA processing
THIT_RS10350	COG2208	phosphoserine phosphatase activity
THIT_RS10360	COG2226	methyltransferase
THIT_RS10365	COG0697	spore germination
THIT_RS10380	COG1131	(ABC) transporter
THIT_RS10410	COG0860	N-Acetylmuramoyl-L-alanine amidase
THIT_RS10425	COG2608	mercury ion transmembrane transporter activity
THIT_RS10430	COG2217	Heavy metal translocating P-type atpase
THIT_RS10440	COG0037	tRNA processing
THIT_RS10445	COG0745	RESPONSE REGULATOR receiver
THIT_RS10470	COG1598	PFAM Uncharacterised protein family UPF0150
THIT_RS10505	COG1396	sequence-specific DNA binding
THIT_RS10540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THIT_RS10545	COG1621	beta-fructofuranosidase activity
THIT_RS10555	COG1621	beta-fructofuranosidase activity
THIT_RS10565	COG0395	ABC-type sugar transport system, permease component
THIT_RS10570	COG1175	transmembrane transport
THIT_RS10585	COG1609	Transcriptional regulator
THIT_RS10665	COG0248	Ppx GppA phosphatase
THIT_RS10665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THIT_RS10670	COG1098	S1 RNA binding domain
THIT_RS10705	COG2385	sporulation resulting in formation of a cellular spore
THIT_RS10710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THIT_RS10715	COG0776	regulation of translation
THIT_RS10720	COG3956	TIGRFAM MazG family protein
THIT_RS10730	COG2814	Major facilitator Superfamily
THIT_RS10735	COG1160	GTP binding
THIT_RS10740	COG1027	Aspartate ammonia-lyase
THIT_RS10745	COG5002	protein histidine kinase activity
THIT_RS10750	COG2033	superoxide reductase activity
THIT_RS10770	COG0142	geranyltranstransferase activity
THIT_RS10785	COG1252	NADH dehydrogenase
THIT_RS10825	COG1725	Transcriptional regulator
THIT_RS10850	COG0137	argininosuccinate synthase activity
THIT_RS10860	COG0505	Belongs to the CarA family
THIT_RS10865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THIT_RS10870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THIT_RS10875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THIT_RS10915	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
THIT_RS10915	COG0493	'glutamate synthase
THIT_RS10920	COG1796	DNA polymerase
THIT_RS10920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THIT_RS10985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THIT_RS10990	COG0671	phosphoesterase, PA-phosphatase related
THIT_RS10995	COG3859	Proton-coupled thiamine transporter YuaJ
THIT_RS11000	COG1132	(ABC) transporter
THIT_RS11010	COG1846	Transcriptional regulator
THIT_RS11015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THIT_RS11020	COG1454	alcohol dehydrogenase
THIT_RS11020	COG1012	belongs to the aldehyde dehydrogenase family
THIT_RS11030	COG0667	Aldo Keto reductase
THIT_RS11035	COG0167	dihydroorotate dehydrogenase activity
THIT_RS11040	COG0747	negative chemotaxis
THIT_RS11045	COG0601	transmembrane transport
THIT_RS11055	COG0444	Belongs to the ABC transporter superfamily
THIT_RS11060	COG4608	Belongs to the ABC transporter superfamily
THIT_RS11065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THIT_RS11070	COG0018	arginyl-trna synthetase
THIT_RS11090	COG2959	enzyme of heme biosynthesis
THIT_RS11110	COG0531	amino acid
THIT_RS11115	COG0697	spore germination
THIT_RS11130	COG1802	Transcriptional regulator
THIT_RS11140	COG1388	LysM domain
THIT_RS11145	COG4466	Protein conserved in bacteria
THIT_RS11155	COG2002	toxin-antitoxin pair type II binding
THIT_RS11160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THIT_RS11165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THIT_RS11180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THIT_RS11185	COG5002	protein histidine kinase activity
THIT_RS11190	COG0745	RESPONSE REGULATOR receiver
THIT_RS11195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THIT_RS11200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THIT_RS11210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THIT_RS11215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THIT_RS11230	COG1609	Transcriptional regulator
THIT_RS11240	COG0071	Belongs to the small heat shock protein (HSP20) family
THIT_RS11255	COG3344	reverse transcriptase
THIT_RS11265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THIT_RS11265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THIT_RS11265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THIT_RS11275	COG1349	DNA-binding transcription factor activity
THIT_RS11280	COG2373	Large extracellular alpha-helical protein
THIT_RS11310	COG0504	CTP synthase activity
THIT_RS11320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THIT_RS11325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THIT_RS11330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THIT_RS11335	COG0793	Belongs to the peptidase S41A family
THIT_RS11335	COG3409	Peptidoglycan-binding domain 1 protein
THIT_RS11340	COG0083	homoserine kinase activity
THIT_RS11345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THIT_RS11350	COG0460	homoserine dehydrogenase
THIT_RS11365	COG0531	amino acid
THIT_RS11370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
THIT_RS11375	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THIT_RS11380	COG1518	maintenance of DNA repeat elements
THIT_RS11455	COG0822	iron-sulfur transferase activity
THIT_RS11460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THIT_RS11470	COG0719	Fe-S assembly protein
THIT_RS11475	COG0396	ATPase activity
THIT_RS11480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THIT_RS11505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THIT_RS11515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THIT_RS11520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THIT_RS11525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THIT_RS11560	COG0739	heme binding
THIT_RS11570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THIT_RS11575	COG0308	aminopeptidase N
THIT_RS11585	COG0658	competence protein
THIT_RS11585	COG2333	competence protein COMEC
THIT_RS11605	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
THIT_RS11610	COG0840	transmembrane signaling receptor activity
THIT_RS11620	COG1164	Oligoendopeptidase f
THIT_RS11625	COG0733	neurotransmitter:sodium symporter activity
THIT_RS11655	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
THIT_RS11660	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
THIT_RS11665	COG1527	subunit (C
THIT_RS11670	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
THIT_RS11675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THIT_RS11680	COG1269	ATP hydrolysis coupled proton transport
THIT_RS11695	COG3328	transposase activity
THIT_RS11700	COG0640	Transcriptional regulator
THIT_RS11705	COG1131	(ABC) transporter
THIT_RS11860	COG0305	Participates in initiation and elongation during chromosome replication
THIT_RS11870	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
THIT_RS11890	COG0629	single-stranded DNA binding
THIT_RS11900	COG4481	Protein conserved in bacteria
THIT_RS11905	COG0668	transmembrane transport
THIT_RS11920	COG4242	Belongs to the peptidase S51 family
THIT_RS11930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THIT_RS11935	COG1475	DNA binding
THIT_RS11940	COG1192	Involved in chromosome partitioning
THIT_RS11945	COG1475	DNA binding
THIT_RS11955	COG3344	reverse transcriptase
THIT_RS11970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THIT_RS11975	COG1847	R3H domain protein
THIT_RS11980	COG0706	membrane insertase activity