locus-tag	class	description
TKV_RS00010	COG0592	DNA-directed DNA polymerase activity
TKV_RS00030	COG3442	glutamine amidotransferase
TKV_RS00040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TKV_RS00045	COG0187	DNA topoisomerase II activity
TKV_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TKV_RS00060	COG0439	Biotin carboxylase
TKV_RS00065	COG0440	acetolactate synthase activity
TKV_RS00075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TKV_RS00085	COG0066	3-isopropylmalate dehydratase activity
TKV_RS00090	COG0473	3-isopropylmalate dehydrogenase activity
TKV_RS00095	COG0129	dihydroxy-acid dehydratase activity
TKV_RS00100	COG0028	Belongs to the TPP enzyme family
TKV_RS00120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TKV_RS00125	COG0628	permease
TKV_RS00150	COG1316	TRANSCRIPTIONal
TKV_RS00155	COG1615	UPF0182 protein
TKV_RS00190	COG1785	Belongs to the alkaline phosphatase family
TKV_RS00225	COG3464	Transposase
TKV_RS00230	COG2199	diguanylate cyclase activity
TKV_RS00230	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TKV_RS00235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TKV_RS00240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TKV_RS00245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TKV_RS00250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TKV_RS00255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TKV_RS00260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TKV_RS00305	COG1028	Short-chain dehydrogenase reductase Sdr
TKV_RS00310	COG1187	pseudouridine synthase activity
TKV_RS00315	COG1609	Transcriptional regulator
TKV_RS00320	COG1653	transport
TKV_RS00325	COG1175	transmembrane transport
TKV_RS00330	COG0395	ABC-type sugar transport system, permease component
TKV_RS00340	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TKV_RS00345	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TKV_RS00350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TKV_RS00375	COG1511	domain protein
TKV_RS00380	COG0037	tRNA processing
TKV_RS00395	COG1573	uracil-dna glycosylase
TKV_RS00425	COG0425	Belongs to the sulfur carrier protein TusA family
TKV_RS00430	COG2391	methyltransferase activity
TKV_RS00450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TKV_RS00465	COG0519	Catalyzes the synthesis of GMP from XMP
TKV_RS00475	COG1982	Orn Lys Arg decarboxylase major
TKV_RS00485	COG3870	Protein conserved in bacteria
TKV_RS00495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TKV_RS00500	COG1774	PSP1 C-terminal conserved region
TKV_RS00510	COG0730	response to heat
TKV_RS00520	COG2235	arginine
TKV_RS00525	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TKV_RS00530	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TKV_RS00535	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TKV_RS00540	COG2002	toxin-antitoxin pair type II binding
TKV_RS00545	COG2715	membrane protein required for spore maturation
TKV_RS00550	COG0700	Nucleoside recognition
TKV_RS00555	COG0617	tRNA 3'-terminal CCA addition
TKV_RS00560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TKV_RS00560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TKV_RS00565	COG0084	hydrolase, TatD family'
TKV_RS00570	COG3584	3D domain protein
TKV_RS00570	COG3583	domain protein
TKV_RS00575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TKV_RS00590	COG4447	cellulose binding
TKV_RS00595	COG1191	sigma factor activity
TKV_RS00600	COG2151	metal-sulfur cluster biosynthetic enzyme
TKV_RS00600	COG0489	protein tyrosine kinase activity
TKV_RS00610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TKV_RS00615	COG2111	Na H antiporter
TKV_RS00615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TKV_RS00620	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TKV_RS00625	COG3260	NADH ubiquinone oxidoreductase 20
TKV_RS00630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TKV_RS00635	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TKV_RS00665	COG0375	protein maturation
TKV_RS00670	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TKV_RS00680	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TKV_RS00685	COG0298	carbon dioxide binding
TKV_RS00690	COG0409	Hydrogenase expression formation protein
TKV_RS00705	COG0745	RESPONSE REGULATOR receiver
TKV_RS00715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TKV_RS00730	COG3872	metal-dependent enzyme
TKV_RS00735	COG2890	protein-(glutamine-N5) methyltransferase activity
TKV_RS00750	COG0009	L-threonylcarbamoyladenylate synthase
TKV_RS00755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TKV_RS00760	COG0698	ribose 5-phosphate isomerase
TKV_RS00775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TKV_RS00780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TKV_RS00795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TKV_RS00830	COG1361	Conserved repeat domain
TKV_RS00835	COG2385	sporulation resulting in formation of a cellular spore
TKV_RS00845	COG1609	Transcriptional regulator
TKV_RS00855	COG4786	Flagellar basal body rod
TKV_RS00870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TKV_RS00885	COG1496	oxidoreductase activity
TKV_RS00905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TKV_RS00910	COG0569	domain protein
TKV_RS00930	COG1879	ABC-type sugar transport system periplasmic component
TKV_RS00940	COG0348	domain, Protein
TKV_RS00950	COG0436	Aminotransferase
TKV_RS00955	COG1522	sequence-specific DNA binding
TKV_RS00965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TKV_RS00965	COG1918	ferrous iron import across plasma membrane
TKV_RS00970	COG1122	ATPase activity
TKV_RS00975	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TKV_RS00980	COG0310	cobalt ion transport
TKV_RS00985	COG0310	cobalt ion transport
TKV_RS01010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TKV_RS01020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TKV_RS01025	COG1136	(ABC) transporter
TKV_RS01030	COG0577	efflux transmembrane transporter activity
TKV_RS01030	COG1136	(ABC) transporter
TKV_RS01040	COG0179	Fumarylacetoacetate (FAA) hydrolase
TKV_RS01060	COG1074	ATP-dependent DNA helicase activity
TKV_RS01065	COG0420	3'-5' exonuclease activity
TKV_RS01070	COG0419	ATPase involved in DNA repair
TKV_RS01080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TKV_RS01085	COG0450	alkyl hydroperoxide reductase
TKV_RS01110	COG0297	glycogen (starch) synthase activity
TKV_RS01115	COG0586	Pfam SNARE associated Golgi protein
TKV_RS01170	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TKV_RS01175	COG1980	fructose-bisphosphate aldolase activity
TKV_RS01180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TKV_RS01185	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TKV_RS01195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TKV_RS01200	COG3464	Transposase
TKV_RS01205	COG0095	Lipoate-protein ligase
TKV_RS01215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TKV_RS01225	COG0436	Aminotransferase
TKV_RS01275	COG1979	alcohol dehydrogenase
TKV_RS01295	COG1309	transcriptional regulator
TKV_RS01310	COG1924	4 iron, 4 sulfur cluster binding
TKV_RS01315	COG1230	cation diffusion facilitator family transporter
TKV_RS01325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TKV_RS01330	COG0390	transport system, permease component
TKV_RS01335	COG0823	Involved in the tonB-independent uptake of proteins
TKV_RS01345	COG0495	leucyl-tRNA aminoacylation
TKV_RS01350	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TKV_RS01360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TKV_RS01360	COG1522	sequence-specific DNA binding
TKV_RS01365	COG2313	pseudouridylate synthase activity
TKV_RS01375	COG0306	phosphate transporter
TKV_RS01385	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TKV_RS01385	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TKV_RS01390	COG2213	PTS system mannitol-specific
TKV_RS01395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TKV_RS01395	COG3711	transcriptional antiterminator
TKV_RS01410	COG0737	Belongs to the 5'-nucleotidase family
TKV_RS01415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TKV_RS01425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TKV_RS01430	COG1121	(ABC) transporter
TKV_RS01435	COG0803	Belongs to the bacterial solute-binding protein 9 family
TKV_RS01440	COG0735	belongs to the Fur family
TKV_RS01445	COG1704	LemA family
TKV_RS01480	COG0351	phosphomethylpyrimidine kinase
TKV_RS01485	COG0352	thiamine-phosphate diphosphorylase activity
TKV_RS01525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TKV_RS01530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TKV_RS01535	COG1120	ATPase activity
TKV_RS01540	COG1797	cobyrinic acid a,c-diamide synthase activity
TKV_RS01545	COG1492	cobalamin metabolic process
TKV_RS01565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TKV_RS01570	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
TKV_RS01625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TKV_RS01640	COG0113	porphobilinogen synthase activity
TKV_RS01645	COG1648	precorrin-2 dehydrogenase activity
TKV_RS01645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TKV_RS01660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TKV_RS01665	COG0310	cobalt ion transport
TKV_RS01680	COG1122	ATPase activity
TKV_RS01705	COG4555	ABC transporter
TKV_RS01750	COG1131	(ABC) transporter
TKV_RS01765	COG1131	(ABC) transporter
TKV_RS01830	COG1131	(ABC) transporter
TKV_RS01840	COG2771	luxR family
TKV_RS01875	COG1131	(ABC) transporter
TKV_RS01895	COG1131	(ABC) transporter
TKV_RS01900	COG3464	Transposase
TKV_RS01925	COG1132	(ABC) transporter
TKV_RS01935	COG0602	queuosine metabolic process
TKV_RS01950	COG4555	ABC transporter
TKV_RS01955	COG1668	transmembrane transport
TKV_RS01995	COG0577	efflux transmembrane transporter activity
TKV_RS01995	COG1136	(ABC) transporter
TKV_RS02035	COG1131	(ABC) transporter
TKV_RS02095	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TKV_RS02120	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TKV_RS02120	COG2199	diguanylate cyclase activity
TKV_RS02135	COG0840	transmembrane signaling receptor activity
TKV_RS02145	COG1744	ABC transporter substrate-binding protein PnrA-like
TKV_RS02150	COG3845	ABC transporter
TKV_RS02155	COG4603	Belongs to the binding-protein-dependent transport system permease family
TKV_RS02160	COG1079	Belongs to the binding-protein-dependent transport system permease family
TKV_RS02165	COG2188	Transcriptional regulator
TKV_RS02195	COG1263	PTS System
TKV_RS02195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TKV_RS02200	COG2190	(PTS) system
TKV_RS02205	COG3711	transcriptional antiterminator
TKV_RS02210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TKV_RS02240	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TKV_RS02250	COG2323	membrane
TKV_RS02255	COG0561	phosphatase activity
TKV_RS02260	COG1609	Transcriptional regulator
TKV_RS02265	COG0745	RESPONSE REGULATOR receiver
TKV_RS02270	COG5002	protein histidine kinase activity
TKV_RS02310	COG1592	Rubrerythrin
TKV_RS02315	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TKV_RS02325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TKV_RS02330	COG1040	competence protein
TKV_RS02350	COG1256	bacterial-type flagellum assembly
TKV_RS02350	COG4786	Flagellar basal body rod
TKV_RS02355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TKV_RS02365	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TKV_RS02370	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TKV_RS02395	COG0367	asparagine synthase
TKV_RS02410	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TKV_RS02415	COG1516	flagellar protein fliS
TKV_RS02425	COG0840	transmembrane signaling receptor activity
TKV_RS02435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TKV_RS02440	COG0765	amino acid transport
TKV_RS02470	COG1827	regulation of RNA biosynthetic process
TKV_RS02480	COG0653	protein targeting
TKV_RS02485	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TKV_RS02490	COG2183	response to ionizing radiation
TKV_RS02530	COG1131	(ABC) transporter
TKV_RS02540	COG0842	Transport permease protein
TKV_RS02545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TKV_RS02555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TKV_RS02560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TKV_RS02570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TKV_RS02575	COG1120	ATPase activity
TKV_RS02580	COG0398	Pfam SNARE associated Golgi protein
TKV_RS02595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TKV_RS02600	COG0549	Belongs to the carbamate kinase family
TKV_RS02605	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
TKV_RS02610	COG0802	atpase or kinase
TKV_RS02615	COG1214	PFAM Peptidase M22, glycoprotease
TKV_RS02625	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TKV_RS02630	COG0488	(ABC) transporter
TKV_RS02635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TKV_RS02655	COG3279	Response regulator of the LytR AlgR family
TKV_RS02660	COG3290	protein histidine kinase activity
TKV_RS02690	COG0424	maF-like protein
TKV_RS02695	COG1811	Na channel or pump
TKV_RS02705	COG1404	Belongs to the peptidase S8 family
TKV_RS02740	COG0516	GMP reductase activity
TKV_RS02740	COG0517	IMP dehydrogenase activity
TKV_RS02745	COG0519	Catalyzes the synthesis of GMP from XMP
TKV_RS02745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TKV_RS02750	COG2252	PERMEase
TKV_RS02755	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TKV_RS02765	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TKV_RS02770	COG0047	phosphoribosylformylglycinamidine synthase activity
TKV_RS02775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TKV_RS02780	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TKV_RS02785	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TKV_RS02790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TKV_RS02800	COG0151	Belongs to the GarS family
TKV_RS02805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TKV_RS02810	COG1473	amidohydrolase
TKV_RS02820	COG2244	polysaccharide biosynthetic process
TKV_RS02830	COG3711	transcriptional antiterminator
TKV_RS02840	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TKV_RS02845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TKV_RS02850	COG1447	Phosphotransferase system cellobiose-specific component IIA
TKV_RS02855	COG4496	protein, YerC YecD
TKV_RS02860	COG0210	DNA helicase
TKV_RS02880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TKV_RS02885	COG4166	transmembrane transport
TKV_RS02890	COG4166	transmembrane transport
TKV_RS02895	COG0601	transmembrane transport
TKV_RS02900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TKV_RS02905	COG0444	Belongs to the ABC transporter superfamily
TKV_RS02910	COG4608	Belongs to the ABC transporter superfamily
TKV_RS02925	COG0860	N-Acetylmuramoyl-L-alanine amidase
TKV_RS02925	COG2247	cell wall binding repeat
TKV_RS02990	COG3711	transcriptional antiterminator
TKV_RS02990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TKV_RS02995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_RS02995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TKV_RS02995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_RS03005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_RS03010	COG0622	Phosphoesterase
TKV_RS03015	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TKV_RS03015	COG0778	Nitroreductase
TKV_RS03045	COG0411	ABC transporter
TKV_RS03055	COG0704	Plays a role in the regulation of phosphate uptake
TKV_RS03065	COG3464	Transposase
TKV_RS03085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TKV_RS03090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TKV_RS03105	COG0356	it plays a direct role in the translocation of protons across the membrane
TKV_RS03110	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TKV_RS03115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TKV_RS03120	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TKV_RS03125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TKV_RS03130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TKV_RS03135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TKV_RS03140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TKV_RS03150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TKV_RS03150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TKV_RS03155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TKV_RS03160	COG1116	anion transmembrane transporter activity
TKV_RS03210	COG0673	inositol 2-dehydrogenase activity
TKV_RS03215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TKV_RS03245	COG0438	transferase activity, transferring glycosyl groups
TKV_RS03260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TKV_RS03270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TKV_RS03280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TKV_RS03295	COG1201	RNA secondary structure unwinding
TKV_RS03330	COG1401	restriction endodeoxyribonuclease activity
TKV_RS03340	COG2314	TM2 domain
TKV_RS03345	COG1714	RDD family
TKV_RS03365	COG1704	LemA family
TKV_RS03370	COG0622	Phosphoesterase
TKV_RS03450	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TKV_RS03460	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TKV_RS03465	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TKV_RS03470	COG0531	amino acid
TKV_RS03475	COG0250	Participates in transcription elongation, termination and antitermination
TKV_RS03485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TKV_RS03500	COG0489	protein tyrosine kinase activity
TKV_RS03510	COG1316	TRANSCRIPTIONal
TKV_RS03515	COG3949	Membrane
TKV_RS03525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TKV_RS03540	COG0477	Major facilitator Superfamily
TKV_RS03555	COG0671	phosphoesterase, PA-phosphatase related
TKV_RS03570	COG0156	8-amino-7-oxononanoate synthase activity
TKV_RS03580	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
TKV_RS03585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TKV_RS03590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TKV_RS03595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TKV_RS03605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TKV_RS03625	COG1606	tRNA processing
TKV_RS03630	COG1691	(AIR) carboxylase
TKV_RS03635	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TKV_RS03640	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TKV_RS03645	COG5002	protein histidine kinase activity
TKV_RS03650	COG0745	RESPONSE REGULATOR receiver
TKV_RS03665	COG1268	BioY protein
TKV_RS03720	COG0493	'glutamate synthase
TKV_RS03770	COG2986	histidine ammonia-lyase
TKV_RS03805	COG1266	CAAX protease self-immunity
TKV_RS03855	COG0525	valine-tRNA ligase activity
TKV_RS03865	COG0285	dihydrofolate synthase activity
TKV_RS03875	COG1151	hydroxylamine reductase activity
TKV_RS03880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TKV_RS03945	COG1131	(ABC) transporter
TKV_RS03965	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TKV_RS03970	COG1609	Transcriptional regulator
TKV_RS03985	COG1175	transmembrane transport
TKV_RS03990	COG0395	ABC-type sugar transport system, permease component
TKV_RS03995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TKV_RS04005	COG2022	thiamine diphosphate biosynthetic process
TKV_RS04015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TKV_RS04020	COG0352	thiamine-phosphate diphosphorylase activity
TKV_RS04050	COG1404	Belongs to the peptidase S8 family
TKV_RS04055	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TKV_RS04055	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TKV_RS04075	COG3773	Cell wall hydrolase
TKV_RS04075	COG3409	Peptidoglycan-binding domain 1 protein
TKV_RS04100	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TKV_RS04110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TKV_RS04140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TKV_RS04145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TKV_RS04155	COG0739	heme binding
TKV_RS04185	COG1131	(ABC) transporter
TKV_RS04195	COG0616	signal peptide processing
TKV_RS04230	COG4475	Protein of unknown function (DUF436)
TKV_RS04250	COG1983	PspC domain protein
TKV_RS04260	COG1113	amino acid transport
TKV_RS04275	COG1966	Carbon starvation protein
TKV_RS04280	COG3279	Response regulator of the LytR AlgR family
TKV_RS04285	COG3275	phosphorelay sensor kinase activity
TKV_RS04290	COG1595	DNA-templated transcription, initiation
TKV_RS04300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TKV_RS04300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TKV_RS04305	COG0237	dephospho-CoA kinase activity
TKV_RS04310	COG0741	lytic transglycosylase activity
TKV_RS04325	COG0352	thiamine-phosphate diphosphorylase activity
TKV_RS04340	COG0791	NLP P60 protein
TKV_RS04345	COG1217	gtp-binding protein TYPA
TKV_RS04350	COG0741	lytic transglycosylase activity
TKV_RS04370	COG2003	Belongs to the UPF0758 family
TKV_RS04375	COG1077	Cell shape determining protein MreB Mrl
TKV_RS04400	COG2894	cell division
TKV_RS04410	COG0772	Belongs to the SEDS family
TKV_RS04420	COG0739	heme binding
TKV_RS04425	COG0517	IMP dehydrogenase activity
TKV_RS04425	COG1994	Peptidase M50
TKV_RS04440	COG1530	ribonuclease E activity
TKV_RS04450	COG4708	membrane
TKV_RS04455	COG5416	Lipopolysaccharide assembly protein A domain
TKV_RS04490	COG1713	HD superfamily hydrolase involved in NAD metabolism
TKV_RS04495	COG1316	TRANSCRIPTIONal
TKV_RS04500	COG0799	negative regulation of ribosome biogenesis
TKV_RS04520	COG0367	asparagine synthase
TKV_RS04525	COG1686	Belongs to the peptidase S11 family
TKV_RS04530	COG1596	polysaccharide export
TKV_RS04530	COG1555	photosystem II stabilization
TKV_RS04540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TKV_RS04565	COG0318	PFAM AMP-dependent synthetase and ligase
TKV_RS04605	COG0084	hydrolase, TatD family'
TKV_RS04635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TKV_RS04655	COG1429	ligase activity, forming nitrogen-metal bonds
TKV_RS04660	COG0310	cobalt ion transport
TKV_RS04675	COG3437	response regulator, receiver
TKV_RS04675	COG2770	Histidine kinase
TKV_RS04680	COG3706	GGDEF domain
TKV_RS04690	COG4720	Psort location CytoplasmicMembrane, score
TKV_RS04705	COG2333	competence protein COMEC
TKV_RS04705	COG0658	competence protein
TKV_RS04715	COG0268	Binds directly to 16S ribosomal RNA
TKV_RS04725	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TKV_RS04750	COG0481	GTPase activity
TKV_RS04755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TKV_RS04760	COG1420	regulation of RNA biosynthetic process
TKV_RS04765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TKV_RS04770	COG0443	Heat shock 70 kDa protein
TKV_RS04775	COG0484	heat shock protein binding
TKV_RS04780	COG2264	protein methyltransferase activity
TKV_RS04785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TKV_RS04790	COG3830	Belongs to the UPF0237 family
TKV_RS04800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TKV_RS04805	COG0537	adenosine 5'-monophosphoramidase activity
TKV_RS04830	COG1702	phosphate starvation-inducible protein PhoH
TKV_RS04835	COG1480	7TM receptor with intracellular HD hydrolase
TKV_RS04845	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TKV_RS04860	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TKV_RS04875	COG0423	glycine-tRNA ligase activity
TKV_RS04880	COG0517	IMP dehydrogenase activity
TKV_RS04890	COG0574	Belongs to the PEP-utilizing enzyme family
TKV_RS04890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TKV_RS04900	COG0557	exoribonuclease II activity
TKV_RS04920	COG0601	transmembrane transport
TKV_RS04925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TKV_RS04930	COG0444	Belongs to the ABC transporter superfamily
TKV_RS04935	COG4608	Belongs to the ABC transporter superfamily
TKV_RS04945	COG2345	Transcriptional regulator
TKV_RS04960	COG0747	negative chemotaxis
TKV_RS04965	COG1429	ligase activity, forming nitrogen-metal bonds
TKV_RS04970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TKV_RS05000	COG0583	DNA-binding transcription factor activity
TKV_RS05010	COG2267	carboxylic ester hydrolase activity
TKV_RS05030	COG0584	glycerophosphoryl diester phosphodiesterase
TKV_RS05060	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TKV_RS05065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TKV_RS05065	COG0574	Belongs to the PEP-utilizing enzyme family
TKV_RS05075	COG1131	(ABC) transporter
TKV_RS05085	COG2814	Major facilitator Superfamily
TKV_RS05140	COG1215	transferase activity, transferring glycosyl groups
TKV_RS05150	COG3069	C4-dicarboxylate transmembrane transporter activity
TKV_RS05165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TKV_RS05175	COG4632	Exopolysaccharide biosynthesis protein
TKV_RS05175	COG5434	Belongs to the glycosyl hydrolase 28 family
TKV_RS05185	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TKV_RS05190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TKV_RS05205	COG1760	l-serine dehydratase
TKV_RS05210	COG1164	Oligoendopeptidase f
TKV_RS05215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TKV_RS05220	COG0077	Prephenate dehydratase
TKV_RS05220	COG1605	Chorismate mutase
TKV_RS05225	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TKV_RS05230	COG0287	Prephenate dehydrogenase
TKV_RS05240	COG0745	RESPONSE REGULATOR receiver
TKV_RS05245	COG5002	protein histidine kinase activity
TKV_RS05255	COG2119	membrane
TKV_RS05265	COG1940	carbohydrate kinase activity
TKV_RS05275	COG3118	belongs to the thioredoxin family
TKV_RS05280	COG1982	Orn Lys Arg decarboxylase major
TKV_RS05305	COG1523	belongs to the glycosyl hydrolase 13 family
TKV_RS05315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TKV_RS05320	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TKV_RS05325	COG0297	glycogen (starch) synthase activity
TKV_RS05375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TKV_RS05390	COG1739	Uncharacterized protein family UPF0029
TKV_RS05415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TKV_RS05420	COG0217	transcriptional regulatory protein
TKV_RS05425	COG0835	chemotaxis
TKV_RS05435	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TKV_RS05455	COG2247	cell wall binding repeat
TKV_RS05455	COG2385	sporulation resulting in formation of a cellular spore
TKV_RS05500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TKV_RS05505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TKV_RS05510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TKV_RS05520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TKV_RS05520	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TKV_RS05525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TKV_RS05530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TKV_RS05540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TKV_RS05555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TKV_RS05560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TKV_RS05565	COG1937	Protein conserved in bacteria
TKV_RS05570	COG3118	belongs to the thioredoxin family
TKV_RS05585	COG1959	2 iron, 2 sulfur cluster binding
TKV_RS05595	COG0628	permease
TKV_RS05605	COG4472	Bacterial protein of unknown function (DUF965)
TKV_RS05610	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TKV_RS05620	COG0735	belongs to the Fur family
TKV_RS05625	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TKV_RS05630	COG3679	Belongs to the UPF0342 family
TKV_RS05635	COG4708	membrane
TKV_RS05640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TKV_RS05645	COG4122	O-methyltransferase activity
TKV_RS05650	COG0826	peptidase U32
TKV_RS05655	COG0768	penicillin binding
TKV_RS05665	COG0546	phosphoglycolate phosphatase activity
TKV_RS05670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TKV_RS05675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TKV_RS05685	COG1459	type II secretion system
TKV_RS05690	COG2165	general secretion pathway protein
TKV_RS05695	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TKV_RS05765	COG0006	proline dipeptidase activity
TKV_RS05780	COG3854	ATPases associated with a variety of cellular activities
TKV_RS05820	COG1302	Protein conserved in bacteria
TKV_RS05840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TKV_RS05845	COG1570	exodeoxyribonuclease VII activity
TKV_RS05865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TKV_RS05870	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TKV_RS05880	COG1438	arginine binding
TKV_RS05885	COG0497	DNA recombination
TKV_RS05890	COG0750	zinc metalloprotease
TKV_RS05895	COG0745	RESPONSE REGULATOR receiver
TKV_RS05950	COG1379	DNA repair
TKV_RS05955	COG1300	Membrane
TKV_RS05960	COG4974	Belongs to the 'phage' integrase family
TKV_RS05965	COG1686	Belongs to the peptidase S11 family
TKV_RS05970	COG1366	Belongs to the anti-sigma-factor antagonist family
TKV_RS05985	COG3360	Dodecin
TKV_RS06005	COG0517	IMP dehydrogenase activity
TKV_RS06005	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TKV_RS06005	COG0617	tRNA 3'-terminal CCA addition
TKV_RS06010	COG1994	Peptidase M50
TKV_RS06020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TKV_RS06025	COG4086	secreted protein
TKV_RS06035	COG3874	Sporulation protein YtfJ
TKV_RS06045	COG1686	Belongs to the peptidase S11 family
TKV_RS06055	COG0445	tRNA wobble uridine modification
TKV_RS06060	COG1187	pseudouridine synthase activity
TKV_RS06075	COG0010	Belongs to the arginase family
TKV_RS06085	COG1705	Flagellar rod assembly protein muramidase FlgJ
TKV_RS06085	COG1388	LysM domain
TKV_RS06115	COG2081	HI0933 family
TKV_RS06130	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TKV_RS06145	COG0539	negative regulation of cytoplasmic translation
TKV_RS06145	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TKV_RS06155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TKV_RS06165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TKV_RS06170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TKV_RS06185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TKV_RS06190	COG0328	RNA-DNA hybrid ribonuclease activity
TKV_RS06195	COG4974	Belongs to the 'phage' integrase family
TKV_RS06200	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TKV_RS06205	COG0464	growth
TKV_RS06210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TKV_RS06225	COG2359	stage V sporulation protein S
TKV_RS06230	COG1692	metallophosphoesterase
TKV_RS06250	COG2137	regulation of response to DNA damage stimulus
TKV_RS06255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TKV_RS06260	COG1058	Belongs to the CinA family
TKV_RS06260	COG1546	Belongs to the CinA family
TKV_RS06270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TKV_RS06275	COG1674	ftsk spoiiie
TKV_RS06285	COG0740	serine-type endopeptidase activity
TKV_RS06290	COG0527	aspartate kinase activity
TKV_RS06305	COG0612	Peptidase, M16
TKV_RS06310	COG0726	polysaccharide deacetylase
TKV_RS06315	COG1185	polyribonucleotide nucleotidyltransferase activity
TKV_RS06325	COG0196	riboflavin kinase activity
TKV_RS06330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TKV_RS06335	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TKV_RS06340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TKV_RS06355	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TKV_RS06360	COG0195	Participates in both transcription termination and antitermination
TKV_RS06365	COG0779	Required for maturation of 30S ribosomal subunits
TKV_RS06370	COG2176	DNA-directed DNA polymerase activity
TKV_RS06380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TKV_RS06385	COG0750	zinc metalloprotease
TKV_RS06400	COG0750	zinc metalloprotease
TKV_RS06405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TKV_RS06410	COG4589	Belongs to the CDS family
TKV_RS06415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TKV_RS06430	COG0528	UMP kinase activity
TKV_RS06440	COG0052	Belongs to the universal ribosomal protein uS2 family
TKV_RS06455	COG1191	sigma factor activity
TKV_RS06460	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TKV_RS06465	COG1776	CheC inhibitor of MCP methylation
TKV_RS06470	COG0835	chemotaxis
TKV_RS06475	COG0643	Histidine kinase
TKV_RS06475	COG2198	Histidine kinase
TKV_RS06480	COG2201	protein-glutamate methylesterase activity
TKV_RS06495	COG1419	protein localization to endoplasmic reticulum
TKV_RS06500	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TKV_RS06505	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TKV_RS06510	COG1684	flagellar biosynthetic protein fliR
TKV_RS06515	COG1987	bacterial-type flagellum assembly
TKV_RS06520	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TKV_RS06530	COG1582	Flagellar protein (FlbD)
TKV_RS06545	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TKV_RS06565	COG1157	protein secretion by the type III secretion system
TKV_RS06575	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TKV_RS06580	COG1766	The M ring may be actively involved in energy transduction
TKV_RS06585	COG1677	Flagellar hook-basal body complex protein FliE
TKV_RS06595	COG1815	bacterial-type flagellum-dependent cell motility
TKV_RS06600	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
TKV_RS06605	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TKV_RS06610	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TKV_RS06615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TKV_RS06620	COG0758	DNA mediated transformation
TKV_RS06625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TKV_RS06630	COG0792	nuclease activity
TKV_RS06635	COG0180	Tryptophanyl-tRNA synthetase
TKV_RS06640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TKV_RS06660	COG0336	Belongs to the RNA methyltransferase TrmD family
TKV_RS06670	COG1837	Belongs to the UPF0109 family
TKV_RS06680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TKV_RS06690	COG0552	protein localization to endoplasmic reticulum
TKV_RS06695	COG1196	nuclear chromosome segregation
TKV_RS06705	COG2359	stage V sporulation protein S
TKV_RS06715	COG0571	ribonuclease III activity
TKV_RS06720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TKV_RS06730	COG1028	Short-chain dehydrogenase reductase Sdr
TKV_RS06735	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TKV_RS06740	COG2070	2-Nitropropane dioxygenase
TKV_RS06745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TKV_RS06760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TKV_RS06770	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TKV_RS06775	COG0280	phosphate acetyltransferase
TKV_RS06785	COG3314	Sporulation integral membrane protein YlbJ
TKV_RS06800	COG0742	ribosomal rna small subunit methyltransferase
TKV_RS06815	COG1307	EDD domain protein, DegV family
TKV_RS06820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TKV_RS06825	COG1461	Dihydroxyacetone kinase
TKV_RS06830	COG1302	Protein conserved in bacteria
TKV_RS06850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TKV_RS06855	COG1162	GTPase activity
TKV_RS06860	COG2815	serine threonine protein kinase
TKV_RS06860	COG0515	serine threonine protein kinase
TKV_RS06865	COG0631	protein serine/threonine phosphatase activity
TKV_RS06875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TKV_RS06875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TKV_RS06880	COG2738	Putative neutral zinc metallopeptidase
TKV_RS06890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TKV_RS06895	COG0242	peptide deformylase activity
TKV_RS06900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TKV_RS06905	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TKV_RS06915	COG0194	GDP metabolic process
TKV_RS06925	COG1561	YicC-like family, N-terminal region
TKV_RS06930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TKV_RS06935	COG2814	Major facilitator Superfamily
TKV_RS06975	COG0037	tRNA processing
TKV_RS07000	COG0543	2 iron, 2 sulfur cluster binding
TKV_RS07015	COG0540	Belongs to the ATCase OTCase family
TKV_RS07025	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TKV_RS07030	COG0564	pseudouridine synthase activity
TKV_RS07035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TKV_RS07075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TKV_RS07120	COG1337	RAMP superfamily
TKV_RS07150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TKV_RS07160	COG1970	mechanosensitive ion channel activity
TKV_RS07175	COG3706	GGDEF domain
TKV_RS07180	COG2200	EAL domain
TKV_RS07195	COG1983	PspC domain protein
TKV_RS07215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TKV_RS07220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TKV_RS07240	COG0134	indole-3-glycerol-phosphate synthase activity
TKV_RS07250	COG0512	Glutamine amidotransferase of anthranilate synthase
TKV_RS07250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TKV_RS07265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TKV_RS07280	COG3599	regulation of cell shape
TKV_RS07285	COG2302	S4 RNA-binding domain
TKV_RS07300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TKV_RS07330	COG0157	Belongs to the NadC ModD family
TKV_RS07335	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TKV_RS07340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TKV_RS07360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TKV_RS07375	COG1160	GTP binding
TKV_RS07415	COG0704	Plays a role in the regulation of phosphate uptake
TKV_RS07420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TKV_RS07425	COG0581	inorganic phosphate transmembrane transporter activity
TKV_RS07430	COG0573	inorganic phosphate transmembrane transporter activity
TKV_RS07440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TKV_RS07445	COG5002	protein histidine kinase activity
TKV_RS07450	COG0745	RESPONSE REGULATOR receiver
TKV_RS07455	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TKV_RS07460	COG1873	PFAM PRC-barrel domain
TKV_RS07465	COG1191	sigma factor activity
TKV_RS07470	COG1191	sigma factor activity
TKV_RS07480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TKV_RS07485	COG0849	cell division
TKV_RS07490	COG3856	small basic protein
TKV_RS07500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TKV_RS07505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TKV_RS07515	COG0772	Belongs to the SEDS family
TKV_RS07525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TKV_RS07530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TKV_RS07535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TKV_RS07540	COG0768	penicillin binding
TKV_RS07560	COG0612	Peptidase, M16
TKV_RS07565	COG0612	Peptidase, M16
TKV_RS07575	COG0012	GTP binding
TKV_RS07610	COG2033	superoxide reductase activity
TKV_RS07620	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TKV_RS07630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TKV_RS07640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TKV_RS07655	COG2340	Cysteine-rich secretory protein family
TKV_RS07660	COG1362	aminopeptidase activity
TKV_RS07665	COG2197	response regulator
TKV_RS07685	COG1683	Conserved Protein
TKV_RS07690	COG1193	negative regulation of DNA recombination
TKV_RS07695	COG0826	peptidase U32
TKV_RS07715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TKV_RS07715	COG0072	phenylalanine-tRNA ligase activity
TKV_RS07720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TKV_RS07725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TKV_RS07730	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TKV_RS07735	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TKV_RS07740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TKV_RS07745	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TKV_RS07755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TKV_RS07760	COG4399	Belongs to the UPF0754 family
TKV_RS07775	COG0745	RESPONSE REGULATOR receiver
TKV_RS07780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TKV_RS07820	COG1278	Cold shock
TKV_RS07825	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TKV_RS07840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TKV_RS07865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TKV_RS07875	COG1482	cell wall glycoprotein biosynthetic process
TKV_RS07900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TKV_RS07905	COG2384	SAM-dependent methyltransferase
TKV_RS07920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TKV_RS07925	COG0358	DNA primase activity
TKV_RS07930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TKV_RS07935	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TKV_RS07945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TKV_RS07955	COG0126	phosphoglycerate kinase activity
TKV_RS07965	COG2390	Transcriptional regulator
TKV_RS07970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TKV_RS07975	COG1254	Belongs to the acylphosphatase family
TKV_RS07980	COG0561	phosphatase activity
TKV_RS07990	COG2720	vancomycin resistance protein
TKV_RS07995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TKV_RS08000	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TKV_RS08005	COG1067	ATP-dependent peptidase activity
TKV_RS08030	COG1120	ATPase activity
TKV_RS08050	COG4607	ABC-type enterochelin transport system periplasmic component
TKV_RS08060	COG0842	Transport permease protein
TKV_RS08065	COG1131	(ABC) transporter
TKV_RS08075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TKV_RS08080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TKV_RS08090	COG0564	pseudouridine synthase activity
TKV_RS08105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TKV_RS08130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TKV_RS08140	COG3546	catalase activity
TKV_RS08145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TKV_RS08150	COG0646	methionine synthase
TKV_RS08150	COG1410	methionine synthase
TKV_RS08155	COG0058	SHG alpha-glucan phosphorylase activity
TKV_RS08160	COG0166	Belongs to the GPI family
TKV_RS08165	COG0778	Nitroreductase
TKV_RS08170	COG2195	Cleaves the N-terminal amino acid of tripeptides
TKV_RS08180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TKV_RS08185	COG0534	Mate efflux family protein
TKV_RS08205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TKV_RS08240	COG4109	DRTGG domain
TKV_RS08245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TKV_RS08260	COG0366	Alpha amylase catalytic
TKV_RS08265	COG1426	Protein conserved in bacteria
TKV_RS08280	COG3833	ABC-type maltose transport systems, permease component
TKV_RS08285	COG3464	Transposase
TKV_RS08295	COG1175	transmembrane transport
TKV_RS08300	COG2182	Extracellular solute-binding protein
TKV_RS08325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TKV_RS08340	COG1752	Esterase of the alpha-beta hydrolase superfamily
TKV_RS08345	COG1309	transcriptional regulator
TKV_RS08350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TKV_RS08370	COG0671	phosphoesterase, PA-phosphatase related
TKV_RS08385	COG2217	Heavy metal translocating P-type atpase
TKV_RS08390	COG2608	mercury ion transmembrane transporter activity
TKV_RS08395	COG0586	Pfam SNARE associated Golgi protein
TKV_RS08440	COG1337	RAMP superfamily
TKV_RS08480	COG1120	ATPase activity
TKV_RS08485	COG4139	cobalamin transport
TKV_RS08520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TKV_RS08540	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TKV_RS08560	COG0589	response to stress
TKV_RS08615	COG0768	penicillin binding
TKV_RS08645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TKV_RS08650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TKV_RS08690	COG2078	PFAM AMMECR1 domain protein
TKV_RS08690	COG3885	ferrous iron binding
TKV_RS08705	COG0318	PFAM AMP-dependent synthetase and ligase
TKV_RS08710	COG1940	carbohydrate kinase activity
TKV_RS08735	COG0768	penicillin binding
TKV_RS08755	COG0556	nucleotide-excision repair
TKV_RS08760	COG2045	Belongs to the ComB family
TKV_RS08765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TKV_RS08770	COG0793	Belongs to the peptidase S41A family
TKV_RS08770	COG3409	Peptidoglycan-binding domain 1 protein
TKV_RS08775	COG0739	heme binding
TKV_RS08780	COG2177	Part of the ABC transporter FtsEX involved in
TKV_RS08785	COG2884	Cell division ATP-binding protein ftsE
TKV_RS08790	COG3835	regulator
TKV_RS08795	COG3842	ATPase activity
TKV_RS08805	COG0019	diaminopimelate decarboxylase activity
TKV_RS08820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TKV_RS08830	COG4166	transmembrane transport
TKV_RS08835	COG0849	cell division
TKV_RS08865	COG0443	Heat shock 70 kDa protein
TKV_RS08895	COG2205	protein histidine kinase activity
TKV_RS08900	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TKV_RS08905	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TKV_RS08910	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TKV_RS08915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TKV_RS08920	COG1283	sodium-dependent phosphate transmembrane transporter activity
TKV_RS08935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TKV_RS08940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TKV_RS08940	COG0140	phosphoribosyl-ATP diphosphatase activity
TKV_RS08955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TKV_RS08960	COG0131	Imidazoleglycerol-phosphate dehydratase
TKV_RS08970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TKV_RS09015	COG1131	(ABC) transporter
TKV_RS09020	COG3459	Glycosyltransferase 36 associated
TKV_RS09025	COG0598	Magnesium transport protein CorA
TKV_RS09030	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TKV_RS09030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TKV_RS09040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TKV_RS09045	COG2873	o-acetylhomoserine
TKV_RS09050	COG0460	homoserine dehydrogenase
TKV_RS09065	COG0315	cyclic pyranopterin monophosphate synthase activity
TKV_RS09075	COG1910	domain protein
TKV_RS09080	COG0303	'Molybdopterin
TKV_RS09085	COG0521	Mo-molybdopterin cofactor biosynthetic process
TKV_RS09120	COG2226	methyltransferase
TKV_RS09130	COG2203	Gaf domain
TKV_RS09130	COG3706	GGDEF domain
TKV_RS09130	COG5001	Diguanylate cyclase
TKV_RS09130	COG4251	negative regulation of phosphorylation
TKV_RS09140	COG0205	6-phosphofructokinase activity
TKV_RS09150	COG3958	Transketolase
TKV_RS09155	COG3959	Transketolase, thiamine diphosphate binding domain
TKV_RS09160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TKV_RS09185	COG2337	Toxic component of a toxin-antitoxin (TA) module
TKV_RS09195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TKV_RS09205	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TKV_RS09205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TKV_RS09245	COG1971	Probably functions as a manganese efflux pump
TKV_RS09255	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TKV_RS09260	COG1793	dna ligase
TKV_RS09265	COG0432	Pfam Uncharacterised protein family UPF0047
TKV_RS09290	COG0509	glycine decarboxylation via glycine cleavage system
TKV_RS09310	COG0640	Transcriptional regulator
TKV_RS09340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TKV_RS09350	COG0318	PFAM AMP-dependent synthetase and ligase
TKV_RS09350	COG0204	Acyl-transferase
TKV_RS09365	COG0280	phosphate acetyltransferase
TKV_RS09395	COG3426	butyrate kinase activity
TKV_RS09405	COG0280	phosphate acetyltransferase
TKV_RS09410	COG3426	butyrate kinase activity
TKV_RS09420	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TKV_RS09455	COG1705	Flagellar rod assembly protein muramidase FlgJ
TKV_RS09455	COG1388	LysM domain
TKV_RS09480	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TKV_RS09495	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TKV_RS09510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TKV_RS09510	COG0730	response to heat
TKV_RS09530	COG0583	DNA-binding transcription factor activity
TKV_RS09550	COG0864	Transcriptional regulator
TKV_RS09555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TKV_RS09560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TKV_RS09580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TKV_RS09585	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TKV_RS09590	COG3260	NADH ubiquinone oxidoreductase 20
TKV_RS09595	COG0651	ATP synthesis coupled electron transport
TKV_RS09600	COG2111	Na H antiporter
TKV_RS09600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TKV_RS09615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TKV_RS09645	COG0509	glycine decarboxylation via glycine cleavage system
TKV_RS09675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TKV_RS09680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TKV_RS09690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TKV_RS09695	COG3404	Formiminotransferase-cyclodeaminase
TKV_RS09705	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TKV_RS09710	COG2116	formate transmembrane transporter activity
TKV_RS09715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TKV_RS09725	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TKV_RS09730	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TKV_RS09735	COG3383	formate dehydrogenase (NAD+) activity
TKV_RS09740	COG0746	molybdenum cofactor guanylyltransferase activity
TKV_RS09750	COG3842	ATPase activity
TKV_RS09775	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TKV_RS09780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TKV_RS09785	COG0321	lipoyl(octanoyl) transferase activity
TKV_RS09795	COG1151	hydroxylamine reductase activity
TKV_RS09800	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TKV_RS09875	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TKV_RS09880	COG1122	ATPase activity
TKV_RS09885	COG1122	ATPase activity
TKV_RS09920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TKV_RS09940	COG0201	protein transport
TKV_RS09970	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TKV_RS10005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TKV_RS10035	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TKV_RS10045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TKV_RS10060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TKV_RS10065	COG1358	cellular component organization or biogenesis
TKV_RS10070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TKV_RS10075	COG0085	RNA polymerase activity
TKV_RS10080	COG0222	ribosome binding
TKV_RS10090	COG0081	regulation of translation
TKV_RS10100	COG0250	Participates in transcription elongation, termination and antitermination
TKV_RS10105	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TKV_RS10110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TKV_RS10115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TKV_RS10125	COG1595	DNA-templated transcription, initiation
TKV_RS10130	COG3688	RNA-binding protein containing a PIN domain
TKV_RS10135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TKV_RS10150	COG1045	serine acetyltransferase
TKV_RS10170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TKV_RS10180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TKV_RS10185	COG4956	integral membrane protein (PIN domain superfamily)
TKV_RS10195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TKV_RS10200	COG1914	H( )-stimulated, divalent metal cation uptake system
TKV_RS10210	COG0542	response to heat
TKV_RS10215	COG3869	Catalyzes the specific phosphorylation of arginine residues in
TKV_RS10220	COG3880	PFAM UvrB UvrC protein
TKV_RS10235	COG0281	malic enzyme
TKV_RS10240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TKV_RS10245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TKV_RS10295	COG0720	synthase
TKV_RS10300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TKV_RS10305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TKV_RS10315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TKV_RS10325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TKV_RS10325	COG5322	oxidoreductase activity
TKV_RS10355	COG0697	spore germination
TKV_RS10360	COG0531	amino acid
TKV_RS10370	COG4684	Psort location CytoplasmicMembrane, score
TKV_RS10375	COG4770	biotin carboxylase activity
TKV_RS10385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TKV_RS10390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TKV_RS10390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TKV_RS10390	COG1703	isobutyryl-CoA mutase activity
TKV_RS10400	COG3852	Histidine kinase
TKV_RS10410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TKV_RS10415	COG0037	tRNA processing
TKV_RS10425	COG2208	phosphoserine phosphatase activity
TKV_RS10435	COG2226	methyltransferase
TKV_RS10440	COG0697	spore germination
TKV_RS10445	COG1595	DNA-templated transcription, initiation
TKV_RS10455	COG1131	(ABC) transporter
TKV_RS10500	COG3842	ATPase activity
TKV_RS10515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TKV_RS10545	COG1131	(ABC) transporter
TKV_RS10550	COG0640	Transcriptional regulator
TKV_RS10590	COG1337	RAMP superfamily
TKV_RS10640	COG1396	sequence-specific DNA binding
TKV_RS10660	COG0248	Ppx GppA phosphatase
TKV_RS10660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TKV_RS10665	COG1098	S1 RNA binding domain
TKV_RS10695	COG2385	sporulation resulting in formation of a cellular spore
TKV_RS10700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TKV_RS10705	COG0776	regulation of translation
TKV_RS10710	COG3956	TIGRFAM MazG family protein
TKV_RS10720	COG2814	Major facilitator Superfamily
TKV_RS10725	COG1160	GTP binding
TKV_RS10730	COG1027	Aspartate ammonia-lyase
TKV_RS10740	COG0745	RESPONSE REGULATOR receiver
TKV_RS10745	COG2033	superoxide reductase activity
TKV_RS10775	COG3464	Transposase
TKV_RS10835	COG0505	Belongs to the CarA family
TKV_RS10840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TKV_RS10845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TKV_RS10850	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TKV_RS10855	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TKV_RS10880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TKV_RS10880	COG1796	DNA polymerase
TKV_RS10890	COG1131	(ABC) transporter
TKV_RS10910	COG1595	DNA-templated transcription, initiation
TKV_RS11020	COG0671	phosphoesterase, PA-phosphatase related
TKV_RS11025	COG3859	Proton-coupled thiamine transporter YuaJ
TKV_RS11030	COG1132	(ABC) transporter
TKV_RS11040	COG1846	Transcriptional regulator
TKV_RS11060	COG1012	belongs to the aldehyde dehydrogenase family
TKV_RS11060	COG1454	alcohol dehydrogenase
TKV_RS11075	COG0667	Aldo Keto reductase
TKV_RS11105	COG1131	(ABC) transporter
TKV_RS11115	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TKV_RS11120	COG0018	arginyl-trna synthetase
TKV_RS11140	COG2959	enzyme of heme biosynthesis
TKV_RS11160	COG0531	amino acid
TKV_RS11165	COG0697	spore germination
TKV_RS11185	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TKV_RS11195	COG4466	Protein conserved in bacteria
TKV_RS11200	COG3464	Transposase
TKV_RS11210	COG2002	toxin-antitoxin pair type II binding
TKV_RS11215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TKV_RS11220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TKV_RS11235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TKV_RS11240	COG5002	protein histidine kinase activity
TKV_RS11240	COG3850	Histidine kinase
TKV_RS11245	COG0745	RESPONSE REGULATOR receiver
TKV_RS11250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TKV_RS11255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TKV_RS11265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TKV_RS11270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TKV_RS11275	COG1609	Transcriptional regulator
TKV_RS11285	COG0071	Belongs to the small heat shock protein (HSP20) family
TKV_RS11300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_RS11300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TKV_RS11300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TKV_RS11310	COG1349	DNA-binding transcription factor activity
TKV_RS11315	COG2373	Large extracellular alpha-helical protein
TKV_RS11330	COG1361	Conserved repeat domain
TKV_RS11335	COG3064	Membrane
TKV_RS11335	COG4991	sh3 domain protein
TKV_RS11335	COG0515	serine threonine protein kinase
TKV_RS11350	COG0504	CTP synthase activity
TKV_RS11385	COG0561	phosphatase activity
TKV_RS11395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TKV_RS11400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TKV_RS11415	COG0083	homoserine kinase activity
TKV_RS11420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TKV_RS11425	COG0460	homoserine dehydrogenase
TKV_RS11440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TKV_RS11450	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TKV_RS11465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TKV_RS11520	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TKV_RS11525	COG1518	maintenance of DNA repeat elements
TKV_RS11615	COG0822	iron-sulfur transferase activity
TKV_RS11620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TKV_RS11630	COG0719	Fe-S assembly protein
TKV_RS11635	COG0396	ATPase activity
TKV_RS11640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TKV_RS11660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TKV_RS11675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TKV_RS11680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TKV_RS11700	COG5002	protein histidine kinase activity
TKV_RS11715	COG0739	heme binding
TKV_RS11745	COG0658	competence protein
TKV_RS11745	COG2333	competence protein COMEC
TKV_RS11755	COG2217	Heavy metal translocating P-type atpase
TKV_RS11760	COG2217	Heavy metal translocating P-type atpase
TKV_RS11785	COG0067	glutamate synthase
TKV_RS11790	COG0505	Belongs to the CarA family
TKV_RS11795	COG0347	Belongs to the P(II) protein family
TKV_RS11800	COG0004	ammonium transporteR
TKV_RS11830	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TKV_RS11835	COG0840	transmembrane signaling receptor activity
TKV_RS11845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TKV_RS11860	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TKV_RS11865	COG1518	maintenance of DNA repeat elements
TKV_RS11975	COG1151	hydroxylamine reductase activity
TKV_RS11980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TKV_RS11985	COG0305	Participates in initiation and elongation during chromosome replication
TKV_RS11995	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TKV_RS12015	COG0629	single-stranded DNA binding
TKV_RS12025	COG4481	Protein conserved in bacteria
TKV_RS12030	COG0668	transmembrane transport
TKV_RS12045	COG4242	Belongs to the peptidase S51 family
TKV_RS12055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TKV_RS12060	COG1475	DNA binding
TKV_RS12065	COG1192	Involved in chromosome partitioning
TKV_RS12095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TKV_RS12100	COG1847	R3H domain protein
TKV_RS12105	COG0706	membrane insertase activity
TKV_RS12140	COG0840	transmembrane signaling receptor activity
TKV_RS12150	COG0640	Transcriptional regulator