locus-tag	class	description
TMATH_RS00010	COG0592	DNA-directed DNA polymerase activity
TMATH_RS00015	COG2501	S4 domain
TMATH_RS00035	COG3442	glutamine amidotransferase
TMATH_RS00045	COG0187	DNA topoisomerase II activity
TMATH_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TMATH_RS00070	COG3464	Transposase
TMATH_RS00105	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TMATH_RS00110	COG1518	maintenance of DNA repeat elements
TMATH_RS00120	COG1203	CRISPR-associated helicase, Cas3
TMATH_RS00145	COG1902	pentaerythritol trinitrate reductase activity
TMATH_RS00150	COG0440	acetolactate synthase activity
TMATH_RS00160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMATH_RS00170	COG0066	3-isopropylmalate dehydratase activity
TMATH_RS00175	COG0473	3-isopropylmalate dehydrogenase activity
TMATH_RS00180	COG0129	dihydroxy-acid dehydratase activity
TMATH_RS00185	COG0028	Belongs to the TPP enzyme family
TMATH_RS00210	COG0628	permease
TMATH_RS00235	COG1316	TRANSCRIPTIONal
TMATH_RS00240	COG1615	UPF0182 protein
TMATH_RS00250	COG0582	viral genome integration into host DNA
TMATH_RS00265	COG1396	sequence-specific DNA binding
TMATH_RS00270	COG3620	sequence-specific DNA binding
TMATH_RS00305	COG2894	cell division
TMATH_RS00310	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
TMATH_RS00415	COG0739	heme binding
TMATH_RS00470	COG1598	PFAM Uncharacterised protein family UPF0150
TMATH_RS00495	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TMATH_RS00495	COG2199	diguanylate cyclase activity
TMATH_RS00500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TMATH_RS00505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TMATH_RS00510	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TMATH_RS00515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TMATH_RS00520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TMATH_RS00525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TMATH_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
TMATH_RS00575	COG1187	pseudouridine synthase activity
TMATH_RS00585	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TMATH_RS00590	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TMATH_RS00595	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TMATH_RS00610	COG1181	Belongs to the D-alanine--D-alanine ligase family
TMATH_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
TMATH_RS00625	COG1511	domain protein
TMATH_RS00635	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TMATH_RS00645	COG1573	uracil-dna glycosylase
TMATH_RS00660	COG3829	transcription factor binding
TMATH_RS00710	COG2391	methyltransferase activity
TMATH_RS00720	COG2391	methyltransferase activity
TMATH_RS00735	COG0519	Catalyzes the synthesis of GMP from XMP
TMATH_RS00745	COG1982	Orn Lys Arg decarboxylase major
TMATH_RS00755	COG3870	Protein conserved in bacteria
TMATH_RS00765	COG0470	DNA polymerase III
TMATH_RS00770	COG1774	PSP1 C-terminal conserved region
TMATH_RS00775	COG2235	arginine
TMATH_RS00780	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TMATH_RS00785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TMATH_RS00795	COG2002	toxin-antitoxin pair type II binding
TMATH_RS00800	COG2715	membrane protein required for spore maturation
TMATH_RS00805	COG0700	Nucleoside recognition
TMATH_RS00810	COG0617	tRNA 3'-terminal CCA addition
TMATH_RS00815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TMATH_RS00815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TMATH_RS00820	COG0084	hydrolase, TatD family'
TMATH_RS00825	COG3584	3D domain protein
TMATH_RS00825	COG3583	domain protein
TMATH_RS00830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TMATH_RS00850	COG4447	cellulose binding
TMATH_RS00855	COG1191	sigma factor activity
TMATH_RS00860	COG2151	metal-sulfur cluster biosynthetic enzyme
TMATH_RS00860	COG0489	protein tyrosine kinase activity
TMATH_RS00875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TMATH_RS00880	COG4656	Part of a membrane complex involved in electron transport
TMATH_RS00885	COG4658	electron transport chain
TMATH_RS00890	COG4659	FMN binding
TMATH_RS00895	COG4660	Part of a membrane complex involved in electron transport
TMATH_RS00900	COG4657	Part of a membrane complex involved in electron transport
TMATH_RS00905	COG2878	Part of a membrane complex involved in electron transport
TMATH_RS00905	COG1245	4Fe-4S binding domain
TMATH_RS00920	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TMATH_RS00935	COG3872	metal-dependent enzyme
TMATH_RS00945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TMATH_RS00950	COG0428	transporter
TMATH_RS00955	COG0009	L-threonylcarbamoyladenylate synthase
TMATH_RS00960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TMATH_RS00965	COG0698	ribose 5-phosphate isomerase
TMATH_RS00980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TMATH_RS00985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TMATH_RS01000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TMATH_RS01005	COG0686	Belongs to the AlaDH PNT family
TMATH_RS01015	COG2385	sporulation resulting in formation of a cellular spore
TMATH_RS01025	COG1609	Transcriptional regulator
TMATH_RS01030	COG1077	Cell shape determining protein MreB Mrl
TMATH_RS01035	COG4786	Flagellar basal body rod
TMATH_RS01050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TMATH_RS01065	COG1496	oxidoreductase activity
TMATH_RS01080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TMATH_RS01080	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TMATH_RS01090	COG3414	Phosphotransferase system galactitol-specific IIB component
TMATH_RS01095	COG3775	system Galactitol-specific IIC component
TMATH_RS01100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TMATH_RS01115	COG4948	Mandelate Racemase Muconate Lactonizing
TMATH_RS01120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TMATH_RS01125	COG0800	Aldolase
TMATH_RS01135	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TMATH_RS01135	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TMATH_RS01140	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMATH_RS01150	COG3716	PTS system mannose fructose sorbose family IID component
TMATH_RS01155	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TMATH_RS01160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TMATH_RS01165	COG0800	Aldolase
TMATH_RS01170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TMATH_RS01175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TMATH_RS01180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TMATH_RS01185	COG0569	domain protein
TMATH_RS01195	COG1070	Carbohydrate kinase
TMATH_RS01200	COG0673	inositol 2-dehydrogenase activity
TMATH_RS01210	COG1904	glucuronate isomerase
TMATH_RS01215	COG0800	Aldolase
TMATH_RS01220	COG0246	Mannitol dehydrogenase
TMATH_RS01225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TMATH_RS01230	COG1312	Catalyzes the dehydration of D-mannonate
TMATH_RS01235	COG4209	transmembrane transport
TMATH_RS01240	COG0395	ABC-type sugar transport system, permease component
TMATH_RS01250	COG3250	beta-galactosidase activity
TMATH_RS01270	COG3458	cephalosporin-C deacetylase activity
TMATH_RS01295	COG0395	ABC-type sugar transport system, permease component
TMATH_RS01300	COG1472	Belongs to the glycosyl hydrolase 3 family
TMATH_RS01315	COG1609	Transcriptional regulator
TMATH_RS01320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TMATH_RS01330	COG1129	ABC transporter
TMATH_RS01335	COG1172	Belongs to the binding-protein-dependent transport system permease family
TMATH_RS01340	COG1879	ABC-type sugar transport system periplasmic component
TMATH_RS01345	COG1737	Transcriptional regulator
TMATH_RS01350	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TMATH_RS01360	COG1175	transmembrane transport
TMATH_RS01365	COG0395	ABC-type sugar transport system, permease component
TMATH_RS01370	COG3842	ATPase activity
TMATH_RS01380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TMATH_RS01385	COG3876	Protein conserved in bacteria
TMATH_RS01390	COG1472	Belongs to the glycosyl hydrolase 3 family
TMATH_RS01395	COG2971	BadF BadG BcrA BcrD
TMATH_RS01400	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TMATH_RS01405	COG0456	acetyltransferase
TMATH_RS01410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TMATH_RS01420	COG1649	PFAM Uncharacterised BCR, COG1649
TMATH_RS01440	COG3464	Transposase
TMATH_RS01455	COG0436	Aminotransferase
TMATH_RS01460	COG1522	sequence-specific DNA binding
TMATH_RS01470	COG1918	ferrous iron import across plasma membrane
TMATH_RS01470	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TMATH_RS01475	COG3464	Transposase
TMATH_RS01485	COG1122	ATPase activity
TMATH_RS01490	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TMATH_RS01495	COG0310	cobalt ion transport
TMATH_RS01500	COG0310	cobalt ion transport
TMATH_RS01505	COG0864	Transcriptional regulator
TMATH_RS01515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TMATH_RS01520	COG0534	Mate efflux family protein
TMATH_RS01525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMATH_RS01530	COG1136	(ABC) transporter
TMATH_RS01535	COG1136	(ABC) transporter
TMATH_RS01535	COG0577	efflux transmembrane transporter activity
TMATH_RS01550	COG0179	Fumarylacetoacetate (FAA) hydrolase
TMATH_RS01560	COG1074	ATP-dependent DNA helicase activity
TMATH_RS01565	COG0420	3'-5' exonuclease activity
TMATH_RS01570	COG0419	ATPase involved in DNA repair
TMATH_RS01575	COG0450	alkyl hydroperoxide reductase
TMATH_RS01600	COG0297	glycogen (starch) synthase activity
TMATH_RS01605	COG0586	Pfam SNARE associated Golgi protein
TMATH_RS01630	COG0493	'glutamate synthase
TMATH_RS01630	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TMATH_RS01645	COG3275	phosphorelay sensor kinase activity
TMATH_RS01650	COG2197	response regulator
TMATH_RS01655	COG4213	ABC transporter substrate-binding protein
TMATH_RS01660	COG4213	ABC transporter substrate-binding protein
TMATH_RS01670	COG4214	carbohydrate transport
TMATH_RS01675	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TMATH_RS01680	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TMATH_RS01690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TMATH_RS01695	COG0095	Lipoate-protein ligase
TMATH_RS01700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TMATH_RS01715	COG0436	Aminotransferase
TMATH_RS01720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMATH_RS01720	COG3711	transcriptional antiterminator
TMATH_RS01725	COG3037	sugar-specific permease SgaT UlaA
TMATH_RS01740	COG3623	hexulose-6-phosphate isomerase
TMATH_RS01765	COG1979	alcohol dehydrogenase
TMATH_RS01780	COG1309	transcriptional regulator
TMATH_RS01795	COG1924	4 iron, 4 sulfur cluster binding
TMATH_RS01805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TMATH_RS01810	COG0390	transport system, permease component
TMATH_RS01815	COG0495	leucyl-tRNA aminoacylation
TMATH_RS01820	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TMATH_RS01830	COG1522	sequence-specific DNA binding
TMATH_RS01830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TMATH_RS01835	COG2313	pseudouridylate synthase activity
TMATH_RS01845	COG0306	phosphate transporter
TMATH_RS01855	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TMATH_RS01855	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TMATH_RS01865	COG3394	polysaccharide catabolic process
TMATH_RS01875	COG1447	Phosphotransferase system cellobiose-specific component IIA
TMATH_RS01880	COG1486	melibiose metabolic process
TMATH_RS01885	COG2723	6-phospho-beta-galactosidase activity
TMATH_RS01890	COG2213	PTS system mannitol-specific
TMATH_RS01895	COG3711	transcriptional antiterminator
TMATH_RS01895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMATH_RS01910	COG0737	Belongs to the 5'-nucleotidase family
TMATH_RS01915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TMATH_RS01920	COG0730	response to heat
TMATH_RS01930	COG1609	Transcriptional regulator
TMATH_RS01935	COG4166	transmembrane transport
TMATH_RS01940	COG0601	transmembrane transport
TMATH_RS01945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMATH_RS01950	COG0444	Belongs to the ABC transporter superfamily
TMATH_RS01960	COG3250	beta-galactosidase activity
TMATH_RS01965	COG2723	6-phospho-beta-galactosidase activity
TMATH_RS01970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TMATH_RS01975	COG1121	(ABC) transporter
TMATH_RS01980	COG0803	Belongs to the bacterial solute-binding protein 9 family
TMATH_RS01985	COG0735	belongs to the Fur family
TMATH_RS01990	COG1704	LemA family
TMATH_RS01995	COG0583	DNA-binding transcription factor activity
TMATH_RS02015	COG0084	hydrolase, TatD family'
TMATH_RS02030	COG0822	iron-sulfur transferase activity
TMATH_RS02055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TMATH_RS02060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TMATH_RS02065	COG1120	ATPase activity
TMATH_RS02070	COG1797	cobyrinic acid a,c-diamide synthase activity
TMATH_RS02095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TMATH_RS02160	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TMATH_RS02175	COG0113	porphobilinogen synthase activity
TMATH_RS02180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TMATH_RS02180	COG1648	precorrin-2 dehydrogenase activity
TMATH_RS02195	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TMATH_RS02200	COG0310	cobalt ion transport
TMATH_RS02215	COG1122	ATPase activity
TMATH_RS02265	COG4555	ABC transporter
TMATH_RS02295	COG2814	Major facilitator Superfamily
TMATH_RS02325	COG1131	(ABC) transporter
TMATH_RS02335	COG4566	intracellular signal transduction
TMATH_RS02370	COG1131	(ABC) transporter
TMATH_RS02400	COG0535	radical SAM domain protein
TMATH_RS02405	COG0535	radical SAM domain protein
TMATH_RS02410	COG1131	(ABC) transporter
TMATH_RS02425	COG0778	Nitroreductase
TMATH_RS02440	COG1136	(ABC) transporter
TMATH_RS02455	COG1363	Peptidase, m42
TMATH_RS02480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TMATH_RS02480	COG2199	diguanylate cyclase activity
TMATH_RS02485	COG0840	transmembrane signaling receptor activity
TMATH_RS02495	COG1228	amidohydrolase
TMATH_RS02505	COG0366	Alpha amylase catalytic
TMATH_RS02520	COG1653	transport
TMATH_RS02525	COG2972	Histidine kinase
TMATH_RS02530	COG2207	Transcriptional regulator
TMATH_RS02530	COG4753	response regulator
TMATH_RS02535	COG3404	Formiminotransferase-cyclodeaminase
TMATH_RS02540	COG1744	ABC transporter substrate-binding protein PnrA-like
TMATH_RS02550	COG3845	ABC transporter
TMATH_RS02555	COG4603	Belongs to the binding-protein-dependent transport system permease family
TMATH_RS02560	COG1079	Belongs to the binding-protein-dependent transport system permease family
TMATH_RS02565	COG2188	Transcriptional regulator
TMATH_RS02585	COG0840	transmembrane signaling receptor activity
TMATH_RS02595	COG1263	PTS System
TMATH_RS02595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TMATH_RS02595	COG2190	(PTS) system
TMATH_RS02600	COG2190	(PTS) system
TMATH_RS02605	COG3711	transcriptional antiterminator
TMATH_RS02610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMATH_RS02650	COG2081	HI0933 family
TMATH_RS02675	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TMATH_RS02685	COG2323	membrane
TMATH_RS02690	COG0561	phosphatase activity
TMATH_RS02695	COG1609	Transcriptional regulator
TMATH_RS02700	COG0745	RESPONSE REGULATOR receiver
TMATH_RS02705	COG5002	protein histidine kinase activity
TMATH_RS02745	COG1592	Rubrerythrin
TMATH_RS02750	COG2104	thiamine diphosphate biosynthetic process
TMATH_RS02755	COG0037	tRNA processing
TMATH_RS02760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TMATH_RS02765	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TMATH_RS02770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TMATH_RS02775	COG1040	competence protein
TMATH_RS02795	COG1256	bacterial-type flagellum assembly
TMATH_RS02795	COG4786	Flagellar basal body rod
TMATH_RS02800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TMATH_RS02810	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TMATH_RS02815	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TMATH_RS02835	COG0367	asparagine synthase
TMATH_RS02850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TMATH_RS02855	COG1516	flagellar protein fliS
TMATH_RS02865	COG0840	transmembrane signaling receptor activity
TMATH_RS02875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TMATH_RS02880	COG0765	amino acid transport
TMATH_RS02910	COG1827	regulation of RNA biosynthetic process
TMATH_RS02920	COG0653	protein targeting
TMATH_RS02925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TMATH_RS02930	COG2183	response to ionizing radiation
TMATH_RS02945	COG0398	Pfam SNARE associated Golgi protein
TMATH_RS02960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TMATH_RS02975	COG0802	atpase or kinase
TMATH_RS02980	COG1214	PFAM Peptidase M22, glycoprotease
TMATH_RS02990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TMATH_RS03000	COG0488	(ABC) transporter
TMATH_RS03005	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TMATH_RS03025	COG3279	Response regulator of the LytR AlgR family
TMATH_RS03030	COG3290	protein histidine kinase activity
TMATH_RS03050	COG0493	'glutamate synthase
TMATH_RS03065	COG1811	Na channel or pump
TMATH_RS03075	COG1404	Belongs to the peptidase S8 family
TMATH_RS03110	COG0517	IMP dehydrogenase activity
TMATH_RS03110	COG0516	GMP reductase activity
TMATH_RS03115	COG0519	Catalyzes the synthesis of GMP from XMP
TMATH_RS03115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TMATH_RS03120	COG2252	PERMEase
TMATH_RS03125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TMATH_RS03135	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TMATH_RS03140	COG0047	phosphoribosylformylglycinamidine synthase activity
TMATH_RS03145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TMATH_RS03150	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TMATH_RS03160	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TMATH_RS03165	COG0138	bifunctional purine biosynthesis protein purh
TMATH_RS03170	COG0151	Belongs to the GarS family
TMATH_RS03180	COG1473	amidohydrolase
TMATH_RS03185	COG2244	polysaccharide biosynthetic process
TMATH_RS03195	COG3711	transcriptional antiterminator
TMATH_RS03205	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TMATH_RS03210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TMATH_RS03215	COG1447	Phosphotransferase system cellobiose-specific component IIA
TMATH_RS03225	COG0210	DNA helicase
TMATH_RS03230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TMATH_RS03245	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TMATH_RS03255	COG0860	N-Acetylmuramoyl-L-alanine amidase
TMATH_RS03255	COG2247	cell wall binding repeat
TMATH_RS03330	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TMATH_RS03330	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TMATH_RS03335	COG1447	Phosphotransferase system cellobiose-specific component IIA
TMATH_RS03345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TMATH_RS03355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TMATH_RS03360	COG0698	ribose 5-phosphate isomerase
TMATH_RS03365	COG2723	6-phospho-beta-galactosidase activity
TMATH_RS03375	COG0351	phosphomethylpyrimidine kinase
TMATH_RS03380	COG0352	thiamine-phosphate diphosphorylase activity
TMATH_RS03385	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TMATH_RS03395	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TMATH_RS03400	COG0704	Plays a role in the regulation of phosphate uptake
TMATH_RS03460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TMATH_RS03465	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TMATH_RS03475	COG0356	it plays a direct role in the translocation of protons across the membrane
TMATH_RS03480	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TMATH_RS03485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TMATH_RS03490	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TMATH_RS03495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TMATH_RS03500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TMATH_RS03505	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TMATH_RS03510	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TMATH_RS03520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TMATH_RS03520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TMATH_RS03525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TMATH_RS03530	COG1116	anion transmembrane transporter activity
TMATH_RS03550	COG2239	Acts as a magnesium transporter
TMATH_RS03570	COG3290	protein histidine kinase activity
TMATH_RS03570	COG0840	transmembrane signaling receptor activity
TMATH_RS03580	COG1086	Polysaccharide biosynthesis protein
TMATH_RS03585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TMATH_RS03590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TMATH_RS03595	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
TMATH_RS03605	COG2089	acid synthase
TMATH_RS03610	COG3980	spore coat polysaccharide biosynthesis protein
TMATH_RS03625	COG0438	transferase activity, transferring glycosyl groups
TMATH_RS03640	COG3944	biosynthesis protein
TMATH_RS03670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TMATH_RS03675	COG0622	Phosphoesterase
TMATH_RS03685	COG1914	H( )-stimulated, divalent metal cation uptake system
TMATH_RS03695	COG1598	PFAM Uncharacterised protein family UPF0150
TMATH_RS03775	COG0667	Aldo Keto reductase
TMATH_RS03780	COG1979	alcohol dehydrogenase
TMATH_RS03785	COG0656	L-ascorbic acid biosynthetic process
TMATH_RS03800	COG0789	Transcriptional regulator
TMATH_RS03810	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TMATH_RS03825	COG0250	Participates in transcription elongation, termination and antitermination
TMATH_RS03835	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TMATH_RS03840	COG3944	biosynthesis protein
TMATH_RS03845	COG3949	Membrane
TMATH_RS03855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TMATH_RS03865	COG2814	Major facilitator Superfamily
TMATH_RS03890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TMATH_RS03895	COG1606	tRNA processing
TMATH_RS03900	COG1691	(AIR) carboxylase
TMATH_RS03905	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TMATH_RS03910	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TMATH_RS03915	COG5002	protein histidine kinase activity
TMATH_RS03920	COG0745	RESPONSE REGULATOR receiver
TMATH_RS03940	COG0525	valine-tRNA ligase activity
TMATH_RS03950	COG0285	dihydrofolate synthase activity
TMATH_RS03980	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TMATH_RS03985	COG1609	Transcriptional regulator
TMATH_RS04000	COG1175	transmembrane transport
TMATH_RS04005	COG0395	ABC-type sugar transport system, permease component
TMATH_RS04010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TMATH_RS04025	COG0395	ABC-type sugar transport system, permease component
TMATH_RS04040	COG1404	Belongs to the peptidase S8 family
TMATH_RS04050	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TMATH_RS04050	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TMATH_RS04055	COG3773	Cell wall hydrolase
TMATH_RS04055	COG3409	Peptidoglycan-binding domain 1 protein
TMATH_RS04080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TMATH_RS04090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TMATH_RS04100	COG1132	(ABC) transporter
TMATH_RS04105	COG1132	(ABC) transporter
TMATH_RS04125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TMATH_RS04130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TMATH_RS04140	COG0739	heme binding
TMATH_RS04165	COG0616	signal peptide processing
TMATH_RS04185	COG4475	Protein of unknown function (DUF436)
TMATH_RS04205	COG1131	(ABC) transporter
TMATH_RS04235	COG1113	amino acid transport
TMATH_RS04240	COG1595	DNA-templated transcription, initiation
TMATH_RS04250	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TMATH_RS04250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TMATH_RS04255	COG0237	dephospho-CoA kinase activity
TMATH_RS04270	COG4166	transmembrane transport
TMATH_RS04285	COG0791	NLP P60 protein
TMATH_RS04290	COG1217	gtp-binding protein TYPA
TMATH_RS04295	COG0741	lytic transglycosylase activity
TMATH_RS04315	COG2878	Part of a membrane complex involved in electron transport
TMATH_RS04335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TMATH_RS04335	COG4191	Histidine kinase
TMATH_RS04365	COG2003	Belongs to the UPF0758 family
TMATH_RS04370	COG1077	Cell shape determining protein MreB Mrl
TMATH_RS04385	COG0768	penicillin binding
TMATH_RS04395	COG2894	cell division
TMATH_RS04405	COG0772	Belongs to the SEDS family
TMATH_RS04415	COG0739	heme binding
TMATH_RS04420	COG1994	Peptidase M50
TMATH_RS04420	COG0517	IMP dehydrogenase activity
TMATH_RS04435	COG1530	ribonuclease E activity
TMATH_RS04450	COG3464	Transposase
TMATH_RS04455	COG3464	Transposase
TMATH_RS04460	COG5416	Lipopolysaccharide assembly protein A domain
TMATH_RS04500	COG1713	HD superfamily hydrolase involved in NAD metabolism
TMATH_RS04505	COG1316	TRANSCRIPTIONal
TMATH_RS04510	COG0799	negative regulation of ribosome biogenesis
TMATH_RS04530	COG0367	asparagine synthase
TMATH_RS04535	COG1686	Belongs to the peptidase S11 family
TMATH_RS04540	COG1555	photosystem II stabilization
TMATH_RS04540	COG1596	polysaccharide export
TMATH_RS04550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TMATH_RS04585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TMATH_RS04600	COG4720	Psort location CytoplasmicMembrane, score
TMATH_RS04605	COG0546	phosphoglycolate phosphatase activity
TMATH_RS04610	COG1234	tRNA 3'-trailer cleavage
TMATH_RS04615	COG0658	competence protein
TMATH_RS04615	COG2333	competence protein COMEC
TMATH_RS04625	COG0268	Binds directly to 16S ribosomal RNA
TMATH_RS04630	COG1297	OPT oligopeptide transporter protein
TMATH_RS04645	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TMATH_RS04670	COG0481	GTPase activity
TMATH_RS04675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TMATH_RS04685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TMATH_RS04695	COG0484	heat shock protein binding
TMATH_RS04705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TMATH_RS04710	COG3830	Belongs to the UPF0237 family
TMATH_RS04725	COG0701	Predicted permease
TMATH_RS04740	COG0745	RESPONSE REGULATOR receiver
TMATH_RS04745	COG2770	Histidine kinase
TMATH_RS04745	COG2205	protein histidine kinase activity
TMATH_RS04750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TMATH_RS04760	COG0463	Glycosyl transferase, family 2
TMATH_RS04770	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TMATH_RS04775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMATH_RS04780	COG0537	adenosine 5'-monophosphoramidase activity
TMATH_RS04805	COG1702	phosphate starvation-inducible protein PhoH
TMATH_RS04810	COG1480	7TM receptor with intracellular HD hydrolase
TMATH_RS04820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TMATH_RS04830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TMATH_RS04845	COG0423	glycine-tRNA ligase activity
TMATH_RS04855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TMATH_RS04855	COG0574	Belongs to the PEP-utilizing enzyme family
TMATH_RS04865	COG0557	exoribonuclease II activity
TMATH_RS04940	COG1132	(ABC) transporter
TMATH_RS04960	COG4555	ABC transporter
TMATH_RS05015	COG0693	protein deglycase activity
TMATH_RS05025	COG2267	carboxylic ester hydrolase activity
TMATH_RS05045	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TMATH_RS05065	COG3069	C4-dicarboxylate transmembrane transporter activity
TMATH_RS05075	COG0426	domain, Protein
TMATH_RS05080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TMATH_RS05090	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TMATH_RS05095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TMATH_RS05100	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TMATH_RS05115	COG1760	l-serine dehydratase
TMATH_RS05120	COG1164	Oligoendopeptidase f
TMATH_RS05130	COG0077	Prephenate dehydratase
TMATH_RS05130	COG1605	Chorismate mutase
TMATH_RS05135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TMATH_RS05140	COG0287	Prephenate dehydrogenase
TMATH_RS05155	COG2119	membrane
TMATH_RS05170	COG0745	RESPONSE REGULATOR receiver
TMATH_RS05175	COG2205	protein histidine kinase activity
TMATH_RS05190	COG1940	carbohydrate kinase activity
TMATH_RS05195	COG0363	glucosamine-6-phosphate deaminase activity
TMATH_RS05205	COG0785	Cytochrome C biogenesis protein
TMATH_RS05210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TMATH_RS05215	COG1982	Orn Lys Arg decarboxylase major
TMATH_RS05245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TMATH_RS05260	COG1739	Uncharacterized protein family UPF0029
TMATH_RS05280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TMATH_RS05290	COG0835	chemotaxis
TMATH_RS05300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TMATH_RS05320	COG2385	sporulation resulting in formation of a cellular spore
TMATH_RS05320	COG2247	cell wall binding repeat
TMATH_RS05330	COG0343	queuine tRNA-ribosyltransferase activity
TMATH_RS05345	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TMATH_RS05350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TMATH_RS05355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TMATH_RS05360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TMATH_RS05370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TMATH_RS05370	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TMATH_RS05380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TMATH_RS05385	COG1490	D-aminoacyl-tRNA deacylase activity
TMATH_RS05390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TMATH_RS05395	COG0577	efflux transmembrane transporter activity
TMATH_RS05400	COG1136	(ABC) transporter
TMATH_RS05405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TMATH_RS05420	COG0124	histidyl-tRNA synthetase
TMATH_RS05425	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TMATH_RS05430	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TMATH_RS05435	COG1937	Protein conserved in bacteria
TMATH_RS05440	COG3118	belongs to the thioredoxin family
TMATH_RS05445	COG3457	Alanine racemase
TMATH_RS05450	COG1959	2 iron, 2 sulfur cluster binding
TMATH_RS05455	COG0628	permease
TMATH_RS05465	COG4472	Bacterial protein of unknown function (DUF965)
TMATH_RS05470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TMATH_RS05475	COG3906	Belongs to the UPF0473 family
TMATH_RS05480	COG0735	belongs to the Fur family
TMATH_RS05485	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TMATH_RS05490	COG3679	Belongs to the UPF0342 family
TMATH_RS05500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TMATH_RS05505	COG4122	O-methyltransferase activity
TMATH_RS05510	COG0826	peptidase U32
TMATH_RS05515	COG0768	penicillin binding
TMATH_RS05525	COG0546	phosphoglycolate phosphatase activity
TMATH_RS05530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TMATH_RS05535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TMATH_RS05545	COG1459	type II secretion system
TMATH_RS05555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TMATH_RS05615	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TMATH_RS05625	COG0006	proline dipeptidase activity
TMATH_RS05640	COG3854	ATPases associated with a variety of cellular activities
TMATH_RS05680	COG1302	Protein conserved in bacteria
TMATH_RS05690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TMATH_RS05695	COG1570	exodeoxyribonuclease VII activity
TMATH_RS05715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TMATH_RS05720	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TMATH_RS05730	COG1438	arginine binding
TMATH_RS05735	COG0497	DNA recombination
TMATH_RS05740	COG0750	zinc metalloprotease
TMATH_RS05780	COG1379	DNA repair
TMATH_RS05785	COG1300	Membrane
TMATH_RS05790	COG4974	Belongs to the 'phage' integrase family
TMATH_RS05795	COG1686	Belongs to the peptidase S11 family
TMATH_RS05800	COG1366	Belongs to the anti-sigma-factor antagonist family
TMATH_RS05815	COG3360	Dodecin
TMATH_RS05835	COG0617	tRNA 3'-terminal CCA addition
TMATH_RS05840	COG1994	Peptidase M50
TMATH_RS05850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TMATH_RS05855	COG4086	secreted protein
TMATH_RS05865	COG3874	Sporulation protein YtfJ
TMATH_RS05870	COG1686	Belongs to the peptidase S11 family
TMATH_RS05880	COG0445	tRNA wobble uridine modification
TMATH_RS05885	COG1187	pseudouridine synthase activity
TMATH_RS05910	COG1388	LysM domain
TMATH_RS05910	COG1705	Flagellar rod assembly protein muramidase FlgJ
TMATH_RS05940	COG0406	alpha-ribazole phosphatase activity
TMATH_RS05945	COG2081	HI0933 family
TMATH_RS05960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TMATH_RS05980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TMATH_RS05990	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TMATH_RS06010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TMATH_RS06020	COG4974	Belongs to the 'phage' integrase family
TMATH_RS06025	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TMATH_RS06030	COG0464	growth
TMATH_RS06035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TMATH_RS06045	COG0613	PHP domain protein
TMATH_RS06050	COG2359	stage V sporulation protein S
TMATH_RS06055	COG1692	metallophosphoesterase
TMATH_RS06060	COG1418	mRNA catabolic process
TMATH_RS06065	COG2137	regulation of response to DNA damage stimulus
TMATH_RS06070	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TMATH_RS06075	COG1058	Belongs to the CinA family
TMATH_RS06075	COG1546	Belongs to the CinA family
TMATH_RS06080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TMATH_RS06085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMATH_RS06090	COG1674	ftsk spoiiie
TMATH_RS06100	COG0740	serine-type endopeptidase activity
TMATH_RS06105	COG0527	aspartate kinase activity
TMATH_RS06120	COG0612	Peptidase, M16
TMATH_RS06125	COG0726	polysaccharide deacetylase
TMATH_RS06130	COG1185	polyribonucleotide nucleotidyltransferase activity
TMATH_RS06140	COG0196	riboflavin kinase activity
TMATH_RS06145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TMATH_RS06150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TMATH_RS06155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TMATH_RS06160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TMATH_RS06170	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TMATH_RS06175	COG0195	Participates in both transcription termination and antitermination
TMATH_RS06185	COG2176	DNA-directed DNA polymerase activity
TMATH_RS06195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TMATH_RS06200	COG0750	zinc metalloprotease
TMATH_RS06205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TMATH_RS06210	COG4589	Belongs to the CDS family
TMATH_RS06215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TMATH_RS06225	COG0233	cytoplasmic translational termination
TMATH_RS06230	COG0528	UMP kinase activity
TMATH_RS06255	COG1191	sigma factor activity
TMATH_RS06260	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TMATH_RS06265	COG1776	CheC inhibitor of MCP methylation
TMATH_RS06270	COG0835	chemotaxis
TMATH_RS06275	COG0643	Histidine kinase
TMATH_RS06275	COG2198	Histidine kinase
TMATH_RS06280	COG2201	protein-glutamate methylesterase activity
TMATH_RS06290	COG0455	bacterial-type flagellum organization
TMATH_RS06295	COG1419	protein localization to endoplasmic reticulum
TMATH_RS06300	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TMATH_RS06305	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TMATH_RS06310	COG1684	flagellar biosynthetic protein fliR
TMATH_RS06315	COG1987	bacterial-type flagellum assembly
TMATH_RS06320	COG1338	Plays a role in the flagellum-specific transport system
TMATH_RS06330	COG2201	protein-glutamate methylesterase activity
TMATH_RS06335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TMATH_RS06335	COG1776	CheC inhibitor of MCP methylation
TMATH_RS06340	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TMATH_RS06345	COG1580	Controls the rotational direction of flagella during chemotaxis
TMATH_RS06350	COG1582	Flagellar protein (FlbD)
TMATH_RS06365	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TMATH_RS06385	COG1157	protein secretion by the type III secretion system
TMATH_RS06395	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TMATH_RS06400	COG1766	The M ring may be actively involved in energy transduction
TMATH_RS06405	COG1677	Flagellar hook-basal body complex protein FliE
TMATH_RS06415	COG1815	bacterial-type flagellum-dependent cell motility
TMATH_RS06430	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TMATH_RS06435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TMATH_RS06440	COG0758	DNA mediated transformation
TMATH_RS06445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TMATH_RS06450	COG0792	nuclease activity
TMATH_RS06455	COG0180	Tryptophanyl-tRNA synthetase
TMATH_RS06460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TMATH_RS06465	COG0606	chelatase, subunit chli
TMATH_RS06480	COG0336	Belongs to the RNA methyltransferase TrmD family
TMATH_RS06490	COG1837	Belongs to the UPF0109 family
TMATH_RS06495	COG0228	four-way junction DNA binding
TMATH_RS06500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TMATH_RS06505	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
TMATH_RS06510	COG0552	protein localization to endoplasmic reticulum
TMATH_RS06525	COG2359	stage V sporulation protein S
TMATH_RS06540	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TMATH_RS06545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TMATH_RS06560	COG0437	4 iron, 4 sulfur cluster binding
TMATH_RS06570	COG0067	glutamate synthase
TMATH_RS06575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TMATH_RS06575	COG0519	Catalyzes the synthesis of GMP from XMP
TMATH_RS06580	COG0347	Belongs to the P(II) protein family
TMATH_RS06585	COG0004	ammonium transporteR
TMATH_RS06595	COG0571	ribonuclease III activity
TMATH_RS06600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TMATH_RS06610	COG1028	Short-chain dehydrogenase reductase Sdr
TMATH_RS06615	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TMATH_RS06620	COG2070	2-Nitropropane dioxygenase
TMATH_RS06625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TMATH_RS06630	COG0416	fatty acid biosynthetic process
TMATH_RS06640	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TMATH_RS06645	COG1399	metal-binding, possibly nucleic acid-binding protein
TMATH_RS06650	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TMATH_RS06655	COG0280	phosphate acetyltransferase
TMATH_RS06665	COG3314	Sporulation integral membrane protein YlbJ
TMATH_RS06680	COG0742	ribosomal rna small subunit methyltransferase
TMATH_RS06695	COG1307	EDD domain protein, DegV family
TMATH_RS06700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TMATH_RS06705	COG1461	Dihydroxyacetone kinase
TMATH_RS06710	COG1302	Protein conserved in bacteria
TMATH_RS06730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TMATH_RS06735	COG1162	GTPase activity
TMATH_RS06740	COG2815	serine threonine protein kinase
TMATH_RS06740	COG0515	serine threonine protein kinase
TMATH_RS06745	COG0631	protein serine/threonine phosphatase activity
TMATH_RS06755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TMATH_RS06755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TMATH_RS06760	COG2738	Putative neutral zinc metallopeptidase
TMATH_RS06770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TMATH_RS06775	COG0242	peptide deformylase activity
TMATH_RS06780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TMATH_RS06785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TMATH_RS06795	COG0194	GDP metabolic process
TMATH_RS06805	COG1561	YicC-like family, N-terminal region
TMATH_RS06810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TMATH_RS06815	COG2814	Major facilitator Superfamily
TMATH_RS06835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TMATH_RS06840	COG2011	ABC-type metal ion transport system permease component
TMATH_RS06880	COG0037	tRNA processing
TMATH_RS06905	COG0543	2 iron, 2 sulfur cluster binding
TMATH_RS06910	COG0284	orotidine-5'-phosphate decarboxylase activity
TMATH_RS06920	COG0540	Belongs to the ATCase OTCase family
TMATH_RS06935	COG0564	pseudouridine synthase activity
TMATH_RS06940	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TMATH_RS06990	COG0656	L-ascorbic acid biosynthetic process
TMATH_RS07000	COG1979	alcohol dehydrogenase
TMATH_RS07005	COG0667	Aldo Keto reductase
TMATH_RS07030	COG1970	mechanosensitive ion channel activity
TMATH_RS07040	COG1595	DNA-templated transcription, initiation
TMATH_RS07060	COG1983	PspC domain protein
TMATH_RS07080	COG0626	cystathionine gamma-synthase activity
TMATH_RS07085	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TMATH_RS07105	COG0134	indole-3-glycerol-phosphate synthase activity
TMATH_RS07115	COG0512	Glutamine amidotransferase of anthranilate synthase
TMATH_RS07115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TMATH_RS07135	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TMATH_RS07175	COG3599	regulation of cell shape
TMATH_RS07180	COG2302	S4 RNA-binding domain
TMATH_RS07195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TMATH_RS07210	COG1929	Belongs to the glycerate kinase type-1 family
TMATH_RS07230	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TMATH_RS07240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TMATH_RS07245	COG1160	GTP binding
TMATH_RS07285	COG0704	Plays a role in the regulation of phosphate uptake
TMATH_RS07290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TMATH_RS07300	COG0573	inorganic phosphate transmembrane transporter activity
TMATH_RS07305	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TMATH_RS07310	COG5002	protein histidine kinase activity
TMATH_RS07315	COG0745	RESPONSE REGULATOR receiver
TMATH_RS07325	COG1873	PFAM PRC-barrel domain
TMATH_RS07330	COG1191	sigma factor activity
TMATH_RS07335	COG1191	sigma factor activity
TMATH_RS07345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TMATH_RS07350	COG0849	cell division
TMATH_RS07355	COG3856	small basic protein
TMATH_RS07370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TMATH_RS07380	COG0772	Belongs to the SEDS family
TMATH_RS07395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TMATH_RS07400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TMATH_RS07405	COG0768	penicillin binding
TMATH_RS07425	COG0612	Peptidase, M16
TMATH_RS07430	COG0612	Peptidase, M16
TMATH_RS07440	COG0012	GTP binding
TMATH_RS07475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TMATH_RS07480	COG0321	lipoyl(octanoyl) transferase activity
TMATH_RS07485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TMATH_RS07560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TMATH_RS07570	COG1362	aminopeptidase activity
TMATH_RS07575	COG2197	response regulator
TMATH_RS07595	COG1683	Conserved Protein
TMATH_RS07600	COG1193	negative regulation of DNA recombination
TMATH_RS07605	COG0826	peptidase U32
TMATH_RS07615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TMATH_RS07615	COG0072	phenylalanine-tRNA ligase activity
TMATH_RS07620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TMATH_RS07625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TMATH_RS07640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TMATH_RS07655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TMATH_RS07660	COG4399	Belongs to the UPF0754 family
TMATH_RS07675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TMATH_RS07710	COG1278	Cold shock
TMATH_RS07715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TMATH_RS07730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TMATH_RS07735	COG1956	GAF domain-containing protein
TMATH_RS07755	COG3464	Transposase
TMATH_RS07780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TMATH_RS07795	COG1482	cell wall glycoprotein biosynthetic process
TMATH_RS07805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TMATH_RS07810	COG2384	SAM-dependent methyltransferase
TMATH_RS07825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TMATH_RS07830	COG0358	DNA primase activity
TMATH_RS07835	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TMATH_RS07840	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TMATH_RS07845	COG0148	phosphopyruvate hydratase activity
TMATH_RS07850	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TMATH_RS07855	COG0149	triose-phosphate isomerase activity
TMATH_RS07860	COG0126	phosphoglycerate kinase activity
TMATH_RS07870	COG2390	Transcriptional regulator
TMATH_RS07875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TMATH_RS07880	COG1254	Belongs to the acylphosphatase family
TMATH_RS07885	COG0561	phosphatase activity
TMATH_RS07895	COG2720	vancomycin resistance protein
TMATH_RS07900	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TMATH_RS07905	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TMATH_RS07930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TMATH_RS07940	COG0564	pseudouridine synthase activity
TMATH_RS07955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TMATH_RS07960	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TMATH_RS07980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TMATH_RS07990	COG3546	catalase activity
TMATH_RS07995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TMATH_RS08000	COG1410	methionine synthase
TMATH_RS08000	COG0646	methionine synthase
TMATH_RS08005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TMATH_RS08005	COG0646	methionine synthase
TMATH_RS08010	COG0058	SHG alpha-glucan phosphorylase activity
TMATH_RS08015	COG0166	Belongs to the GPI family
TMATH_RS08020	COG0778	Nitroreductase
TMATH_RS08030	COG0409	Hydrogenase expression formation protein
TMATH_RS08035	COG0298	carbon dioxide binding
TMATH_RS08040	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TMATH_RS08050	COG0375	protein maturation
TMATH_RS08070	COG3260	NADH ubiquinone oxidoreductase 20
TMATH_RS08075	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TMATH_RS08080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TMATH_RS08080	COG2111	Na H antiporter
TMATH_RS08090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TMATH_RS08100	COG1174	glycine betaine transport
TMATH_RS08105	COG1125	glycine betaine transport
TMATH_RS08105	COG0517	IMP dehydrogenase activity
TMATH_RS08110	COG3273	potassium ion transport
TMATH_RS08110	COG0471	metal ion transport
TMATH_RS08115	COG0534	Mate efflux family protein
TMATH_RS08125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TMATH_RS08155	COG4109	DRTGG domain
TMATH_RS08160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMATH_RS08175	COG0366	Alpha amylase catalytic
TMATH_RS08180	COG1426	Protein conserved in bacteria
TMATH_RS08195	COG3833	ABC-type maltose transport systems, permease component
TMATH_RS08200	COG1175	transmembrane transport
TMATH_RS08205	COG2182	Extracellular solute-binding protein
TMATH_RS08230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TMATH_RS08250	COG2217	Heavy metal translocating P-type atpase
TMATH_RS08255	COG0482	sulfurtransferase activity
TMATH_RS08260	COG2608	mercury ion transmembrane transporter activity
TMATH_RS08265	COG0586	Pfam SNARE associated Golgi protein
TMATH_RS08270	COG1342	Belongs to the UPF0251 family
TMATH_RS08275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TMATH_RS08285	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TMATH_RS08305	COG1120	ATPase activity
TMATH_RS08310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TMATH_RS08315	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
TMATH_RS08320	COG0446	pyridine nucleotide-disulphide oxidoreductase
TMATH_RS08325	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TMATH_RS08330	COG1234	tRNA 3'-trailer cleavage
TMATH_RS08340	COG0489	protein tyrosine kinase activity
TMATH_RS08345	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TMATH_RS08370	COG1609	Transcriptional regulator
TMATH_RS08375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TMATH_RS08380	COG1621	beta-fructofuranosidase activity
TMATH_RS08395	COG2182	Extracellular solute-binding protein
TMATH_RS08415	COG0768	penicillin binding
TMATH_RS08430	COG0371	Dehydrogenase
TMATH_RS08435	COG1609	Transcriptional regulator
TMATH_RS08440	COG0235	Class ii aldolase
TMATH_RS08445	COG1069	ribulokinase activity
TMATH_RS08450	COG2160	L-arabinose isomerase activity
TMATH_RS08465	COG3534	alpha-L-arabinofuranosidase
TMATH_RS08470	COG0395	ABC-type sugar transport system, permease component
TMATH_RS08475	COG1175	transmembrane transport
TMATH_RS08480	COG1653	transport
TMATH_RS08485	COG3507	Belongs to the glycosyl hydrolase 43 family
TMATH_RS08505	COG0395	ABC-type sugar transport system, permease component
TMATH_RS08510	COG1175	transmembrane transport
TMATH_RS08515	COG1653	transport
TMATH_RS08520	COG0383	alpha-mannosidase activity
TMATH_RS08525	COG4977	sequence-specific DNA binding
TMATH_RS08525	COG1917	Cupin 2, conserved barrel domain protein
TMATH_RS08530	COG3250	beta-galactosidase activity
TMATH_RS08560	COG1940	carbohydrate kinase activity
TMATH_RS08565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TMATH_RS08570	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TMATH_RS08575	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
TMATH_RS08595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TMATH_RS08615	COG1904	glucuronate isomerase
TMATH_RS08620	COG0246	Mannitol dehydrogenase
TMATH_RS08625	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TMATH_RS08630	COG1070	Carbohydrate kinase
TMATH_RS08635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TMATH_RS08645	COG1349	DNA-binding transcription factor activity
TMATH_RS08650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TMATH_RS08665	COG0673	inositol 2-dehydrogenase activity
TMATH_RS08670	COG0673	inositol 2-dehydrogenase activity
TMATH_RS08700	COG2078	PFAM AMMECR1 domain protein
TMATH_RS08700	COG3885	ferrous iron binding
TMATH_RS08710	COG0318	PFAM AMP-dependent synthetase and ligase
TMATH_RS08745	COG0768	penicillin binding
TMATH_RS08765	COG0556	nucleotide-excision repair
TMATH_RS08770	COG2045	Belongs to the ComB family
TMATH_RS08780	COG0793	Belongs to the peptidase S41A family
TMATH_RS08780	COG3409	Peptidoglycan-binding domain 1 protein
TMATH_RS08785	COG0739	heme binding
TMATH_RS08790	COG2177	Part of the ABC transporter FtsEX involved in
TMATH_RS08795	COG2884	Cell division ATP-binding protein ftsE
TMATH_RS08800	COG3835	regulator
TMATH_RS08805	COG3842	ATPase activity
TMATH_RS08830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TMATH_RS08845	COG0849	cell division
TMATH_RS08870	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
TMATH_RS08870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMATH_RS08870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TMATH_RS08880	COG2376	Dihydroxyacetone kinase
TMATH_RS08885	COG3290	protein histidine kinase activity
TMATH_RS08885	COG3829	transcription factor binding
TMATH_RS08895	COG0446	pyridine nucleotide-disulphide oxidoreductase
TMATH_RS08910	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TMATH_RS08915	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TMATH_RS08935	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TMATH_RS08960	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TMATH_RS08960	COG0140	phosphoribosyl-ATP diphosphatase activity
TMATH_RS08975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TMATH_RS08980	COG0131	Imidazoleglycerol-phosphate dehydratase
TMATH_RS08985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TMATH_RS08990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TMATH_RS09030	COG1131	(ABC) transporter
TMATH_RS09035	COG3459	Glycosyltransferase 36 associated
TMATH_RS09040	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TMATH_RS09040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TMATH_RS09045	COG0673	inositol 2-dehydrogenase activity
TMATH_RS09050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TMATH_RS09055	COG2873	o-acetylhomoserine
TMATH_RS09060	COG0460	homoserine dehydrogenase
TMATH_RS09110	COG3958	Transketolase
TMATH_RS09115	COG3959	Transketolase, thiamine diphosphate binding domain
TMATH_RS09120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TMATH_RS09145	COG2337	Toxic component of a toxin-antitoxin (TA) module
TMATH_RS09155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TMATH_RS09165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TMATH_RS09165	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TMATH_RS09210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TMATH_RS09215	COG1793	dna ligase
TMATH_RS09220	COG0432	Pfam Uncharacterised protein family UPF0047
TMATH_RS09260	COG3464	Transposase
TMATH_RS09290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TMATH_RS09295	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TMATH_RS09305	COG0732	type I restriction modification DNA specificity domain
TMATH_RS09310	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TMATH_RS09330	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TMATH_RS09345	COG0280	phosphate acetyltransferase
TMATH_RS09380	COG3426	butyrate kinase activity
TMATH_RS09390	COG0280	phosphate acetyltransferase
TMATH_RS09395	COG3426	butyrate kinase activity
TMATH_RS09405	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TMATH_RS09425	COG0546	phosphoglycolate phosphatase activity
TMATH_RS09435	COG1388	LysM domain
TMATH_RS09435	COG1705	Flagellar rod assembly protein muramidase FlgJ
TMATH_RS09460	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TMATH_RS09470	COG1966	Carbon starvation protein
TMATH_RS09560	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TMATH_RS09565	COG1122	ATPase activity
TMATH_RS09570	COG1122	ATPase activity
TMATH_RS09600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TMATH_RS09605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TMATH_RS09625	COG0201	protein transport
TMATH_RS09655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TMATH_RS09685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TMATH_RS09690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TMATH_RS09720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TMATH_RS09730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TMATH_RS09745	COG3688	RNA-binding protein containing a PIN domain
TMATH_RS09750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TMATH_RS09765	COG1045	serine acetyltransferase
TMATH_RS09785	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TMATH_RS09795	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TMATH_RS09800	COG4956	integral membrane protein (PIN domain superfamily)
TMATH_RS09810	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TMATH_RS09815	COG1914	H( )-stimulated, divalent metal cation uptake system
TMATH_RS09825	COG3833	ABC-type maltose transport systems, permease component
TMATH_RS09830	COG1175	transmembrane transport
TMATH_RS09835	COG2182	Extracellular solute-binding protein
TMATH_RS09845	COG0542	response to heat
TMATH_RS09850	COG3869	Catalyzes the specific phosphorylation of arginine residues in
TMATH_RS09855	COG3880	PFAM UvrB UvrC protein
TMATH_RS09870	COG0281	malic enzyme
TMATH_RS09875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TMATH_RS09880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TMATH_RS09905	COG4224	UPF0291 protein
TMATH_RS09915	COG1506	peptidase
TMATH_RS09915	COG0823	Involved in the tonB-independent uptake of proteins
TMATH_RS09915	COG4946	Tricorn protease homolog
TMATH_RS09935	COG1131	(ABC) transporter
TMATH_RS10005	COG0720	synthase
TMATH_RS10010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TMATH_RS10015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TMATH_RS10025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TMATH_RS10035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TMATH_RS10035	COG5322	oxidoreductase activity
TMATH_RS10060	COG0697	spore germination
TMATH_RS10065	COG0531	amino acid
TMATH_RS10075	COG4684	Psort location CytoplasmicMembrane, score
TMATH_RS10080	COG4770	biotin carboxylase activity
TMATH_RS10090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TMATH_RS10100	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TMATH_RS10105	COG3852	Histidine kinase
TMATH_RS10115	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TMATH_RS10120	COG0037	tRNA processing
TMATH_RS10125	COG2208	phosphoserine phosphatase activity
TMATH_RS10135	COG2226	methyltransferase
TMATH_RS10140	COG0697	spore germination
TMATH_RS10170	COG0860	N-Acetylmuramoyl-L-alanine amidase
TMATH_RS10185	COG2608	mercury ion transmembrane transporter activity
TMATH_RS10190	COG2217	Heavy metal translocating P-type atpase
TMATH_RS10225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TMATH_RS10270	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TMATH_RS10270	COG0248	Ppx GppA phosphatase
TMATH_RS10275	COG1098	S1 RNA binding domain
TMATH_RS10310	COG2385	sporulation resulting in formation of a cellular spore
TMATH_RS10315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TMATH_RS10320	COG0776	regulation of translation
TMATH_RS10325	COG3956	TIGRFAM MazG family protein
TMATH_RS10335	COG2814	Major facilitator Superfamily
TMATH_RS10340	COG1160	GTP binding
TMATH_RS10345	COG1027	Aspartate ammonia-lyase
TMATH_RS10350	COG2033	superoxide reductase activity
TMATH_RS10370	COG0142	geranyltranstransferase activity
TMATH_RS10385	COG1252	NADH dehydrogenase
TMATH_RS10420	COG1725	Transcriptional regulator
TMATH_RS10445	COG0137	argininosuccinate synthase activity
TMATH_RS10455	COG0505	Belongs to the CarA family
TMATH_RS10460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TMATH_RS10470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TMATH_RS10505	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TMATH_RS10505	COG0493	'glutamate synthase
TMATH_RS10510	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TMATH_RS10510	COG1796	DNA polymerase
TMATH_RS10540	COG0671	phosphoesterase, PA-phosphatase related
TMATH_RS10545	COG3859	Proton-coupled thiamine transporter YuaJ
TMATH_RS10550	COG1132	(ABC) transporter
TMATH_RS10560	COG1846	Transcriptional regulator
TMATH_RS10565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TMATH_RS10570	COG1012	belongs to the aldehyde dehydrogenase family
TMATH_RS10570	COG1454	alcohol dehydrogenase
TMATH_RS10580	COG0667	Aldo Keto reductase
TMATH_RS10585	COG0167	dihydroorotate dehydrogenase activity
TMATH_RS10590	COG0747	negative chemotaxis
TMATH_RS10595	COG0601	transmembrane transport
TMATH_RS10605	COG0444	Belongs to the ABC transporter superfamily
TMATH_RS10610	COG4608	Belongs to the ABC transporter superfamily
TMATH_RS10615	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TMATH_RS10620	COG0018	arginyl-trna synthetase
TMATH_RS10640	COG2959	enzyme of heme biosynthesis
TMATH_RS10660	COG0531	amino acid
TMATH_RS10665	COG0697	spore germination
TMATH_RS10680	COG1802	Transcriptional regulator
TMATH_RS10690	COG1388	LysM domain
TMATH_RS10695	COG4466	Protein conserved in bacteria
TMATH_RS10705	COG2002	toxin-antitoxin pair type II binding
TMATH_RS10710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TMATH_RS10715	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TMATH_RS10730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TMATH_RS10735	COG5002	protein histidine kinase activity
TMATH_RS10740	COG0745	RESPONSE REGULATOR receiver
TMATH_RS10745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TMATH_RS10750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TMATH_RS10760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TMATH_RS10765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TMATH_RS10780	COG1609	Transcriptional regulator
TMATH_RS10790	COG0071	Belongs to the small heat shock protein (HSP20) family
TMATH_RS10810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TMATH_RS10810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TMATH_RS10810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TMATH_RS10820	COG1349	DNA-binding transcription factor activity
TMATH_RS10825	COG2373	Large extracellular alpha-helical protein
TMATH_RS10835	COG1361	Conserved repeat domain
TMATH_RS10835	COG3266	domain, Protein
TMATH_RS10835	COG2911	Protein conserved in bacteria
TMATH_RS10840	COG0515	serine threonine protein kinase
TMATH_RS10840	COG3064	Membrane
TMATH_RS10840	COG4991	sh3 domain protein
TMATH_RS10855	COG0504	CTP synthase activity
TMATH_RS10865	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TMATH_RS10870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TMATH_RS10875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TMATH_RS10880	COG3409	Peptidoglycan-binding domain 1 protein
TMATH_RS10880	COG0793	Belongs to the peptidase S41A family
TMATH_RS10885	COG0083	homoserine kinase activity
TMATH_RS10890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TMATH_RS10895	COG0460	homoserine dehydrogenase
TMATH_RS10905	COG0531	amino acid
TMATH_RS10910	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TMATH_RS10915	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TMATH_RS10920	COG1518	maintenance of DNA repeat elements
TMATH_RS10950	COG1191	sigma factor activity
TMATH_RS11005	COG0822	iron-sulfur transferase activity
TMATH_RS11010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TMATH_RS11020	COG0719	Fe-S assembly protein
TMATH_RS11025	COG0396	ATPase activity
TMATH_RS11030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TMATH_RS11050	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TMATH_RS11060	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TMATH_RS11065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TMATH_RS11070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TMATH_RS11090	COG5002	protein histidine kinase activity
TMATH_RS11105	COG0739	heme binding
TMATH_RS11115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TMATH_RS11120	COG0308	aminopeptidase N
TMATH_RS11130	COG2333	competence protein COMEC
TMATH_RS11130	COG0658	competence protein
TMATH_RS11150	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TMATH_RS11155	COG0840	transmembrane signaling receptor activity
TMATH_RS11165	COG1164	Oligoendopeptidase f
TMATH_RS11170	COG0733	neurotransmitter:sodium symporter activity
TMATH_RS11200	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TMATH_RS11205	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TMATH_RS11210	COG1527	subunit (C
TMATH_RS11215	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TMATH_RS11220	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TMATH_RS11225	COG1269	ATP hydrolysis coupled proton transport
TMATH_RS11275	COG0305	Participates in initiation and elongation during chromosome replication
TMATH_RS11285	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TMATH_RS11305	COG0629	single-stranded DNA binding
TMATH_RS11315	COG4481	Protein conserved in bacteria
TMATH_RS11320	COG0668	transmembrane transport
TMATH_RS11335	COG4242	Belongs to the peptidase S51 family
TMATH_RS11345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TMATH_RS11350	COG1475	DNA binding
TMATH_RS11355	COG1192	Involved in chromosome partitioning
TMATH_RS11360	COG1475	DNA binding
TMATH_RS11380	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TMATH_RS11385	COG1847	R3H domain protein
TMATH_RS11390	COG0706	membrane insertase activity
TMATH_RS11455	COG1136	(ABC) transporter