locus-tag	class	description
THET_RS00010	COG0592	DNA-directed DNA polymerase activity
THET_RS00015	COG2501	S4 domain
THET_RS00035	COG3442	glutamine amidotransferase
THET_RS00045	COG0187	DNA topoisomerase II activity
THET_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THET_RS00055	COG1902	pentaerythritol trinitrate reductase activity
THET_RS00060	COG0440	acetolactate synthase activity
THET_RS00070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THET_RS00080	COG0066	3-isopropylmalate dehydratase activity
THET_RS00085	COG0473	3-isopropylmalate dehydrogenase activity
THET_RS00090	COG0129	dihydroxy-acid dehydratase activity
THET_RS00095	COG0028	Belongs to the TPP enzyme family
THET_RS00120	COG0628	permease
THET_RS00175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THET_RS00175	COG2199	diguanylate cyclase activity
THET_RS00180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THET_RS00195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THET_RS00200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THET_RS00205	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THET_RS00250	COG1028	Short-chain dehydrogenase reductase Sdr
THET_RS00255	COG1187	pseudouridine synthase activity
THET_RS00265	COG1191	sigma factor activity
THET_RS00300	COG4166	transmembrane transport
THET_RS00305	COG0601	transmembrane transport
THET_RS00315	COG0444	Belongs to the ABC transporter superfamily
THET_RS00320	COG4608	Belongs to the ABC transporter superfamily
THET_RS00330	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THET_RS00335	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THET_RS00340	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THET_RS00355	COG1181	Belongs to the D-alanine--D-alanine ligase family
THET_RS00360	COG1028	Short-chain dehydrogenase reductase Sdr
THET_RS00370	COG3103	Sh3 type 3 domain protein
THET_RS00370	COG0366	Alpha amylase catalytic
THET_RS00375	COG0037	tRNA processing
THET_RS00390	COG1573	uracil-dna glycosylase
THET_RS00395	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THET_RS00420	COG0583	DNA-binding transcription factor activity
THET_RS00425	COG2391	methyltransferase activity
THET_RS00435	COG2391	methyltransferase activity
THET_RS00450	COG0519	Catalyzes the synthesis of GMP from XMP
THET_RS00460	COG1982	Orn Lys Arg decarboxylase major
THET_RS00470	COG3870	Protein conserved in bacteria
THET_RS00480	COG0470	DNA polymerase III
THET_RS00485	COG1774	PSP1 C-terminal conserved region
THET_RS00490	COG2235	arginine
THET_RS00495	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
THET_RS00500	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THET_RS00510	COG2002	toxin-antitoxin pair type II binding
THET_RS00515	COG2715	membrane protein required for spore maturation
THET_RS00520	COG0700	Nucleoside recognition
THET_RS00525	COG0617	tRNA 3'-terminal CCA addition
THET_RS00530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THET_RS00530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THET_RS00535	COG0084	hydrolase, TatD family'
THET_RS00540	COG3583	domain protein
THET_RS00540	COG3584	3D domain protein
THET_RS00545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THET_RS00565	COG4447	cellulose binding
THET_RS00570	COG1191	sigma factor activity
THET_RS00575	COG0489	protein tyrosine kinase activity
THET_RS00575	COG2151	metal-sulfur cluster biosynthetic enzyme
THET_RS00590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THET_RS00595	COG4656	Part of a membrane complex involved in electron transport
THET_RS00600	COG4658	electron transport chain
THET_RS00605	COG4659	FMN binding
THET_RS00610	COG4660	Part of a membrane complex involved in electron transport
THET_RS00615	COG4657	Part of a membrane complex involved in electron transport
THET_RS00620	COG1245	4Fe-4S binding domain
THET_RS00620	COG2878	Part of a membrane complex involved in electron transport
THET_RS00630	COG0745	RESPONSE REGULATOR receiver
THET_RS00640	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THET_RS00655	COG3872	metal-dependent enzyme
THET_RS00670	COG0428	transporter
THET_RS00675	COG0009	L-threonylcarbamoyladenylate synthase
THET_RS00680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THET_RS00685	COG0698	ribose 5-phosphate isomerase
THET_RS00710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THET_RS00715	COG0686	Belongs to the AlaDH PNT family
THET_RS00725	COG2385	sporulation resulting in formation of a cellular spore
THET_RS00735	COG1609	Transcriptional regulator
THET_RS00745	COG4786	Flagellar basal body rod
THET_RS00775	COG1496	oxidoreductase activity
THET_RS00790	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THET_RS00790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THET_RS00805	COG3775	system Galactitol-specific IIC component
THET_RS00825	COG4948	Mandelate Racemase Muconate Lactonizing
THET_RS00830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THET_RS00835	COG0800	Aldolase
THET_RS00840	COG2814	Major facilitator Superfamily
THET_RS00845	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THET_RS00845	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THET_RS00850	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
THET_RS00860	COG3716	PTS system mannose fructose sorbose family IID component
THET_RS00865	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THET_RS00870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THET_RS00875	COG0800	Aldolase
THET_RS00880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THET_RS00885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THET_RS00890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THET_RS00895	COG0569	domain protein
THET_RS00910	COG0778	Nitroreductase
THET_RS00925	COG0583	DNA-binding transcription factor activity
THET_RS00955	COG1070	Carbohydrate kinase
THET_RS00960	COG4213	ABC transporter substrate-binding protein
THET_RS00965	COG3344	reverse transcriptase
THET_RS00975	COG4214	carbohydrate transport
THET_RS00990	COG1609	Transcriptional regulator
THET_RS00995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THET_RS01005	COG1129	ABC transporter
THET_RS01010	COG1172	Belongs to the binding-protein-dependent transport system permease family
THET_RS01015	COG1879	ABC-type sugar transport system periplasmic component
THET_RS01020	COG3344	reverse transcriptase
THET_RS01025	COG1737	Transcriptional regulator
THET_RS01035	COG1263	PTS System
THET_RS01035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THET_RS01050	COG2188	Transcriptional regulator
THET_RS01075	COG1735	metal-dependent hydrolase with the TIM-barrel fold
THET_RS01080	COG0626	cystathionine gamma-synthase activity
THET_RS01085	COG3457	Alanine racemase
THET_RS01090	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
THET_RS01095	COG1472	Belongs to the glycosyl hydrolase 3 family
THET_RS01110	COG0436	Aminotransferase
THET_RS01115	COG1522	sequence-specific DNA binding
THET_RS01125	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THET_RS01125	COG1918	ferrous iron import across plasma membrane
THET_RS01130	COG1122	ATPase activity
THET_RS01135	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THET_RS01140	COG0310	cobalt ion transport
THET_RS01145	COG0310	cobalt ion transport
THET_RS01150	COG0864	Transcriptional regulator
THET_RS01160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THET_RS01180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THET_RS01185	COG1136	(ABC) transporter
THET_RS01190	COG1136	(ABC) transporter
THET_RS01190	COG0577	efflux transmembrane transporter activity
THET_RS01195	COG0179	Fumarylacetoacetate (FAA) hydrolase
THET_RS01215	COG0420	3'-5' exonuclease activity
THET_RS01220	COG0419	ATPase involved in DNA repair
THET_RS01230	COG0450	alkyl hydroperoxide reductase
THET_RS01255	COG0297	glycogen (starch) synthase activity
THET_RS01300	COG1980	fructose-bisphosphate aldolase activity
THET_RS01300	COG1980	fructose-bisphosphate aldolase activity
THET_RS01310	COG2972	Histidine kinase
THET_RS01315	COG2197	response regulator
THET_RS01320	COG4213	ABC transporter substrate-binding protein
THET_RS01325	COG4213	ABC transporter substrate-binding protein
THET_RS01330	COG1129	ABC transporter
THET_RS01335	COG4214	carbohydrate transport
THET_RS01340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THET_RS01345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THET_RS01360	COG0095	Lipoate-protein ligase
THET_RS01365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THET_RS01375	COG0436	Aminotransferase
THET_RS01385	COG3037	sugar-specific permease SgaT UlaA
THET_RS01400	COG1979	alcohol dehydrogenase
THET_RS01420	COG0640	Transcriptional regulator
THET_RS01435	COG1309	transcriptional regulator
THET_RS01450	COG1924	4 iron, 4 sulfur cluster binding
THET_RS01460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THET_RS01465	COG0390	transport system, permease component
THET_RS01470	COG0495	leucyl-tRNA aminoacylation
THET_RS01475	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
THET_RS01485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THET_RS01485	COG1522	sequence-specific DNA binding
THET_RS01490	COG2313	pseudouridylate synthase activity
THET_RS01500	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THET_RS01500	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THET_RS01520	COG1447	Phosphotransferase system cellobiose-specific component IIA
THET_RS01525	COG1486	melibiose metabolic process
THET_RS01530	COG2723	6-phospho-beta-galactosidase activity
THET_RS01535	COG2213	PTS system mannitol-specific
THET_RS01540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THET_RS01540	COG3711	transcriptional antiterminator
THET_RS01555	COG0737	Belongs to the 5'-nucleotidase family
THET_RS01560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THET_RS01565	COG0730	response to heat
THET_RS01575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THET_RS01580	COG1121	(ABC) transporter
THET_RS01585	COG0803	Belongs to the bacterial solute-binding protein 9 family
THET_RS01590	COG0735	belongs to the Fur family
THET_RS01595	COG0714	Associated with various cellular activities
THET_RS01610	COG1704	LemA family
THET_RS01615	COG0583	DNA-binding transcription factor activity
THET_RS01640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THET_RS01645	COG0822	iron-sulfur transferase activity
THET_RS01660	COG0116	Belongs to the methyltransferase superfamily
THET_RS01675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THET_RS01680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THET_RS01685	COG1120	ATPase activity
THET_RS01690	COG1797	cobyrinic acid a,c-diamide synthase activity
THET_RS01715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THET_RS01780	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THET_RS01795	COG0113	porphobilinogen synthase activity
THET_RS01800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THET_RS01805	COG0310	cobalt ion transport
THET_RS01820	COG1122	ATPase activity
THET_RS01835	COG4555	ABC transporter
THET_RS01890	COG4555	ABC transporter
THET_RS01895	COG1668	transmembrane transport
THET_RS01920	COG1131	(ABC) transporter
THET_RS01930	COG4566	intracellular signal transduction
THET_RS01940	COG1131	(ABC) transporter
THET_RS02000	COG4555	ABC transporter
THET_RS02005	COG1668	transmembrane transport
THET_RS02040	COG1131	(ABC) transporter
THET_RS02065	COG1363	Peptidase, m42
THET_RS02095	COG3344	reverse transcriptase
THET_RS02105	COG2199	diguanylate cyclase activity
THET_RS02105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THET_RS02115	COG0840	transmembrane signaling receptor activity
THET_RS02125	COG1228	amidohydrolase
THET_RS02140	COG1486	melibiose metabolic process
THET_RS02155	COG1653	transport
THET_RS02160	COG2972	Histidine kinase
THET_RS02165	COG2207	Transcriptional regulator
THET_RS02165	COG4753	response regulator
THET_RS02170	COG3404	Formiminotransferase-cyclodeaminase
THET_RS02175	COG1744	ABC transporter substrate-binding protein PnrA-like
THET_RS02180	COG3845	ABC transporter
THET_RS02185	COG4603	Belongs to the binding-protein-dependent transport system permease family
THET_RS02190	COG1079	Belongs to the binding-protein-dependent transport system permease family
THET_RS02215	COG0840	transmembrane signaling receptor activity
THET_RS02225	COG1263	PTS System
THET_RS02225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THET_RS02225	COG2190	(PTS) system
THET_RS02230	COG2190	(PTS) system
THET_RS02235	COG3711	transcriptional antiterminator
THET_RS02240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THET_RS02285	COG2081	HI0933 family
THET_RS02310	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
THET_RS02315	COG4974	Belongs to the 'phage' integrase family
THET_RS02325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
THET_RS02330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THET_RS02345	COG2323	membrane
THET_RS02350	COG0561	phosphatase activity
THET_RS02355	COG1609	Transcriptional regulator
THET_RS02360	COG0745	RESPONSE REGULATOR receiver
THET_RS02365	COG5002	protein histidine kinase activity
THET_RS02400	COG1592	Rubrerythrin
THET_RS02405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THET_RS02410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THET_RS02415	COG1040	competence protein
THET_RS02435	COG4786	Flagellar basal body rod
THET_RS02435	COG1256	bacterial-type flagellum assembly
THET_RS02440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THET_RS02450	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
THET_RS02455	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THET_RS02485	COG0367	asparagine synthase
THET_RS02500	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THET_RS02505	COG1516	flagellar protein fliS
THET_RS02520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THET_RS02525	COG0765	amino acid transport
THET_RS02555	COG1827	regulation of RNA biosynthetic process
THET_RS02565	COG0653	protein targeting
THET_RS02570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THET_RS02575	COG2183	response to ionizing radiation
THET_RS02585	COG0398	Pfam SNARE associated Golgi protein
THET_RS02595	COG2235	arginine
THET_RS02600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THET_RS02605	COG0549	Belongs to the carbamate kinase family
THET_RS02615	COG3344	reverse transcriptase
THET_RS02620	COG0802	atpase or kinase
THET_RS02625	COG1214	PFAM Peptidase M22, glycoprotease
THET_RS02635	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THET_RS02645	COG0488	(ABC) transporter
THET_RS02670	COG3279	Response regulator of the LytR AlgR family
THET_RS02675	COG3290	protein histidine kinase activity
THET_RS02695	COG0493	'glutamate synthase
THET_RS02710	COG1811	Na channel or pump
THET_RS02720	COG1404	Belongs to the peptidase S8 family
THET_RS02755	COG0517	IMP dehydrogenase activity
THET_RS02755	COG0516	GMP reductase activity
THET_RS02760	COG0519	Catalyzes the synthesis of GMP from XMP
THET_RS02760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THET_RS02765	COG2252	PERMEase
THET_RS02770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THET_RS02780	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THET_RS02785	COG0047	phosphoribosylformylglycinamidine synthase activity
THET_RS02795	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THET_RS02805	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THET_RS02815	COG0151	Belongs to the GarS family
THET_RS02825	COG1473	amidohydrolase
THET_RS02830	COG2244	polysaccharide biosynthetic process
THET_RS02840	COG3711	transcriptional antiterminator
THET_RS02850	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THET_RS02855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THET_RS02860	COG1447	Phosphotransferase system cellobiose-specific component IIA
THET_RS02865	COG4496	protein, YerC YecD
THET_RS02870	COG0210	DNA helicase
THET_RS02910	COG4166	transmembrane transport
THET_RS02915	COG0601	transmembrane transport
THET_RS02920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THET_RS02925	COG0444	Belongs to the ABC transporter superfamily
THET_RS02930	COG4608	Belongs to the ABC transporter superfamily
THET_RS03005	COG0004	ammonium transporteR
THET_RS03010	COG0347	Belongs to the P(II) protein family
THET_RS03015	COG0505	Belongs to the CarA family
THET_RS03020	COG0067	glutamate synthase
THET_RS03030	COG0437	4 iron, 4 sulfur cluster binding
THET_RS03045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THET_RS03055	COG0351	phosphomethylpyrimidine kinase
THET_RS03060	COG0352	thiamine-phosphate diphosphorylase activity
THET_RS03080	COG0704	Plays a role in the regulation of phosphate uptake
THET_RS03120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THET_RS03135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THET_RS03135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THET_RS03140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THET_RS03145	COG1116	anion transmembrane transporter activity
THET_RS03150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THET_RS03155	COG2239	Acts as a magnesium transporter
THET_RS03190	COG0438	transferase activity, transferring glycosyl groups
THET_RS03200	COG0438	transferase activity, transferring glycosyl groups
THET_RS03215	COG0438	transferase activity, transferring glycosyl groups
THET_RS03220	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
THET_RS03275	COG1401	restriction endodeoxyribonuclease activity
THET_RS03290	COG2161	toxin-antitoxin pair type II binding
THET_RS03310	COG1704	LemA family
THET_RS03315	COG0622	Phosphoesterase
THET_RS03320	COG4989	oxidoreductase activity
THET_RS03335	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THET_RS03345	COG1914	H( )-stimulated, divalent metal cation uptake system
THET_RS03400	COG0250	Participates in transcription elongation, termination and antitermination
THET_RS03410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THET_RS03415	COG3944	biosynthesis protein
THET_RS03420	COG0489	protein tyrosine kinase activity
THET_RS03430	COG1316	TRANSCRIPTIONal
THET_RS03435	COG3949	Membrane
THET_RS03445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THET_RS03460	COG2814	Major facilitator Superfamily
THET_RS03475	COG3344	reverse transcriptase
THET_RS03490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THET_RS03495	COG1606	tRNA processing
THET_RS03500	COG1691	(AIR) carboxylase
THET_RS03505	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THET_RS03510	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THET_RS03515	COG5002	protein histidine kinase activity
THET_RS03520	COG0745	RESPONSE REGULATOR receiver
THET_RS03545	COG0525	valine-tRNA ligase activity
THET_RS03555	COG0285	dihydrofolate synthase activity
THET_RS03585	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THET_RS03590	COG1609	Transcriptional regulator
THET_RS03605	COG1175	transmembrane transport
THET_RS03610	COG0395	ABC-type sugar transport system, permease component
THET_RS03615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THET_RS03630	COG0395	ABC-type sugar transport system, permease component
THET_RS03645	COG1404	Belongs to the peptidase S8 family
THET_RS03650	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THET_RS03650	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THET_RS03655	COG3773	Cell wall hydrolase
THET_RS03655	COG3409	Peptidoglycan-binding domain 1 protein
THET_RS03670	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
THET_RS03680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THET_RS03690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THET_RS03700	COG1132	(ABC) transporter
THET_RS03705	COG1132	(ABC) transporter
THET_RS03725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
THET_RS03730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THET_RS03740	COG0739	heme binding
THET_RS03755	COG2986	histidine ammonia-lyase
THET_RS03795	COG4475	Protein of unknown function (DUF436)
THET_RS03820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THET_RS03820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THET_RS03825	COG0237	dephospho-CoA kinase activity
THET_RS03830	COG0741	lytic transglycosylase activity
THET_RS03850	COG0791	NLP P60 protein
THET_RS03855	COG1217	gtp-binding protein TYPA
THET_RS03860	COG0741	lytic transglycosylase activity
THET_RS03880	COG2878	Part of a membrane complex involved in electron transport
THET_RS03900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THET_RS03900	COG4191	Histidine kinase
THET_RS03930	COG2003	Belongs to the UPF0758 family
THET_RS03935	COG1077	Cell shape determining protein MreB Mrl
THET_RS03950	COG0768	penicillin binding
THET_RS03960	COG2894	cell division
THET_RS03970	COG0772	Belongs to the SEDS family
THET_RS03980	COG0739	heme binding
THET_RS03985	COG0517	IMP dehydrogenase activity
THET_RS03985	COG1994	Peptidase M50
THET_RS04000	COG1530	ribonuclease E activity
THET_RS04010	COG4708	membrane
THET_RS04050	COG1713	HD superfamily hydrolase involved in NAD metabolism
THET_RS04055	COG0799	negative regulation of ribosome biogenesis
THET_RS04075	COG0367	asparagine synthase
THET_RS04080	COG1686	Belongs to the peptidase S11 family
THET_RS04085	COG1596	polysaccharide export
THET_RS04085	COG1555	photosystem II stabilization
THET_RS04090	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THET_RS04115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THET_RS04130	COG4720	Psort location CytoplasmicMembrane, score
THET_RS04140	COG1234	tRNA 3'-trailer cleavage
THET_RS04155	COG0268	Binds directly to 16S ribosomal RNA
THET_RS04165	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THET_RS04190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THET_RS04200	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THET_RS04210	COG0484	heat shock protein binding
THET_RS04220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THET_RS04225	COG3830	Belongs to the UPF0237 family
THET_RS04240	COG0701	Predicted permease
THET_RS04250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THET_RS04265	COG1956	GAF domain-containing protein
THET_RS04270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
THET_RS04280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THET_RS04320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THET_RS04325	COG0745	RESPONSE REGULATOR receiver
THET_RS04340	COG4399	Belongs to the UPF0754 family
THET_RS04345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THET_RS04360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THET_RS04375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THET_RS04380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THET_RS04385	COG0072	phenylalanine-tRNA ligase activity
THET_RS04385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THET_RS04395	COG0826	peptidase U32
THET_RS04400	COG1193	negative regulation of DNA recombination
THET_RS04405	COG1683	Conserved Protein
THET_RS04425	COG2197	response regulator
THET_RS04430	COG1362	aminopeptidase activity
THET_RS04445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THET_RS04455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THET_RS04465	COG0459	protein refolding
THET_RS04470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
THET_RS04475	COG0022	dehydrogenase e1 component
THET_RS04480	COG3199	ATP-NAD kinase
THET_RS04485	COG0508	dehydrogenase complex catalyzes the overall conversion of
THET_RS04500	COG3344	reverse transcriptase
THET_RS04525	COG0012	GTP binding
THET_RS04535	COG0612	Peptidase, M16
THET_RS04540	COG0612	Peptidase, M16
THET_RS04555	COG3116	cell division
THET_RS04560	COG0768	penicillin binding
THET_RS04565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THET_RS04570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THET_RS04585	COG0772	Belongs to the SEDS family
THET_RS04595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THET_RS04610	COG3856	small basic protein
THET_RS04615	COG0849	cell division
THET_RS04620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THET_RS04630	COG1191	sigma factor activity
THET_RS04635	COG1191	sigma factor activity
THET_RS04640	COG1873	PFAM PRC-barrel domain
THET_RS04650	COG0745	RESPONSE REGULATOR receiver
THET_RS04655	COG5002	protein histidine kinase activity
THET_RS04660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THET_RS04665	COG0573	inorganic phosphate transmembrane transporter activity
THET_RS04670	COG0581	inorganic phosphate transmembrane transporter activity
THET_RS04675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THET_RS04680	COG0704	Plays a role in the regulation of phosphate uptake
THET_RS04735	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
THET_RS04745	COG5001	Diguanylate cyclase
THET_RS04745	COG5002	protein histidine kinase activity
THET_RS04745	COG3447	MASE1 domain protein
THET_RS04750	COG0745	RESPONSE REGULATOR receiver
THET_RS04760	COG0531	amino acid
THET_RS04765	COG0653	protein targeting
THET_RS04775	COG1131	(ABC) transporter
THET_RS04780	COG2814	Major facilitator Superfamily
THET_RS04795	COG3829	transcription factor binding
THET_RS04800	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THET_RS04825	COG2972	Histidine kinase
THET_RS04830	COG2197	response regulator
THET_RS04840	COG1971	Probably functions as a manganese efflux pump
THET_RS04885	COG4869	propanediol catabolic process
THET_RS04900	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
THET_RS04910	COG1012	belongs to the aldehyde dehydrogenase family
THET_RS04920	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THET_RS04925	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THET_RS04930	COG4810	utilization protein
THET_RS04940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THET_RS04945	COG1454	alcohol dehydrogenase
THET_RS04950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THET_RS04955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THET_RS04960	COG1120	ATPase activity
THET_RS04990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THET_RS04995	COG3959	Transketolase, thiamine diphosphate binding domain
THET_RS05000	COG3958	Transketolase
THET_RS05005	COG0698	ribose 5-phosphate isomerase
THET_RS05015	COG0613	PHP domain protein
THET_RS05025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THET_RS05040	COG1012	belongs to the aldehyde dehydrogenase family
THET_RS05065	COG2376	Dihydroxyacetone kinase
THET_RS05075	COG1461	Dihydroxyacetone kinase
THET_RS05100	COG0632	four-way junction helicase activity
THET_RS05120	COG3835	regulator
THET_RS05125	COG1929	Belongs to the glycerate kinase type-1 family
THET_RS05130	COG2610	gluconate transmembrane transporter activity
THET_RS05145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THET_RS05160	COG2302	S4 RNA-binding domain
THET_RS05165	COG3599	regulation of cell shape
THET_RS05190	COG2188	Transcriptional regulator
THET_RS05205	COG1122	ATPase activity
THET_RS05215	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THET_RS05260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THET_RS05260	COG0512	Glutamine amidotransferase of anthranilate synthase
THET_RS05290	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THET_RS05295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THET_RS05300	COG0626	cystathionine gamma-synthase activity
THET_RS05330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THET_RS05330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THET_RS05335	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THET_RS05335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THET_RS05340	COG1703	isobutyryl-CoA mutase activity
THET_RS05345	COG0346	lactoylglutathione lyase activity
THET_RS05355	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
THET_RS05370	COG1595	DNA-templated transcription, initiation
THET_RS05375	COG0778	Nitroreductase
THET_RS05390	COG1970	mechanosensitive ion channel activity
THET_RS05450	COG1715	Restriction endonuclease
THET_RS05455	COG1715	Restriction endonuclease
THET_RS05460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THET_RS05500	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THET_RS05505	COG0564	pseudouridine synthase activity
THET_RS05520	COG0540	Belongs to the ATCase OTCase family
THET_RS05535	COG0543	2 iron, 2 sulfur cluster binding
THET_RS05560	COG0037	tRNA processing
THET_RS05590	COG2011	ABC-type metal ion transport system permease component
THET_RS05595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
THET_RS05615	COG2814	Major facilitator Superfamily
THET_RS05620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THET_RS05625	COG1561	YicC-like family, N-terminal region
THET_RS05635	COG0194	GDP metabolic process
THET_RS05645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THET_RS05650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THET_RS05665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THET_RS05675	COG2738	Putative neutral zinc metallopeptidase
THET_RS05680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THET_RS05680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THET_RS05690	COG0631	protein serine/threonine phosphatase activity
THET_RS05695	COG0515	serine threonine protein kinase
THET_RS05695	COG2815	serine threonine protein kinase
THET_RS05700	COG1162	GTPase activity
THET_RS05705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THET_RS05725	COG1302	Protein conserved in bacteria
THET_RS05730	COG1461	Dihydroxyacetone kinase
THET_RS05735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THET_RS05740	COG1307	EDD domain protein, DegV family
THET_RS05755	COG0742	ribosomal rna small subunit methyltransferase
THET_RS05770	COG3314	Sporulation integral membrane protein YlbJ
THET_RS05780	COG0280	phosphate acetyltransferase
THET_RS05785	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THET_RS05790	COG1399	metal-binding, possibly nucleic acid-binding protein
THET_RS05795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THET_RS05810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THET_RS05815	COG2070	2-Nitropropane dioxygenase
THET_RS05820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THET_RS05825	COG1028	Short-chain dehydrogenase reductase Sdr
THET_RS05835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THET_RS05840	COG0571	ribonuclease III activity
THET_RS05850	COG2359	stage V sporulation protein S
THET_RS05865	COG0552	protein localization to endoplasmic reticulum
THET_RS05875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THET_RS05885	COG1837	Belongs to the UPF0109 family
THET_RS05895	COG0336	Belongs to the RNA methyltransferase TrmD family
THET_RS05910	COG0606	chelatase, subunit chli
THET_RS05915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THET_RS05920	COG0180	Tryptophanyl-tRNA synthetase
THET_RS05925	COG0792	nuclease activity
THET_RS05930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THET_RS05935	COG0758	DNA mediated transformation
THET_RS05935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THET_RS05940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THET_RS05960	COG1815	bacterial-type flagellum-dependent cell motility
THET_RS05970	COG1677	Flagellar hook-basal body complex protein FliE
THET_RS05975	COG1766	The M ring may be actively involved in energy transduction
THET_RS05980	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THET_RS05990	COG1157	protein secretion by the type III secretion system
THET_RS06010	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THET_RS06025	COG1582	Flagellar protein (FlbD)
THET_RS06035	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THET_RS06040	COG1776	CheC inhibitor of MCP methylation
THET_RS06040	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THET_RS06045	COG2201	protein-glutamate methylesterase activity
THET_RS06055	COG1338	Plays a role in the flagellum-specific transport system
THET_RS06060	COG1987	bacterial-type flagellum assembly
THET_RS06065	COG1684	flagellar biosynthetic protein fliR
THET_RS06070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THET_RS06075	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THET_RS06080	COG1419	protein localization to endoplasmic reticulum
THET_RS06095	COG2201	protein-glutamate methylesterase activity
THET_RS06100	COG2198	Histidine kinase
THET_RS06100	COG0643	Histidine kinase
THET_RS06105	COG0835	chemotaxis
THET_RS06110	COG1776	CheC inhibitor of MCP methylation
THET_RS06115	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THET_RS06120	COG1191	sigma factor activity
THET_RS06145	COG0528	UMP kinase activity
THET_RS06160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THET_RS06165	COG4589	Belongs to the CDS family
THET_RS06175	COG0750	zinc metalloprotease
THET_RS06180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THET_RS06190	COG2176	DNA-directed DNA polymerase activity
THET_RS06200	COG0195	Participates in both transcription termination and antitermination
THET_RS06205	COG2740	Nucleic-acid-binding protein implicated in transcription termination
THET_RS06220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THET_RS06230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THET_RS06235	COG0196	riboflavin kinase activity
THET_RS06250	COG0726	polysaccharide deacetylase
THET_RS06255	COG0612	Peptidase, M16
THET_RS06270	COG0527	aspartate kinase activity
THET_RS06275	COG0740	serine-type endopeptidase activity
THET_RS06285	COG1674	ftsk spoiiie
THET_RS06295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THET_RS06305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THET_RS06310	COG2137	regulation of response to DNA damage stimulus
THET_RS06320	COG1692	metallophosphoesterase
THET_RS06325	COG2359	stage V sporulation protein S
THET_RS06330	COG0613	PHP domain protein
THET_RS06340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THET_RS06345	COG0464	growth
THET_RS06350	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
THET_RS06355	COG4974	Belongs to the 'phage' integrase family
THET_RS06365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THET_RS06385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THET_RS06395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THET_RS06420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THET_RS06435	COG2081	HI0933 family
THET_RS06440	COG0406	alpha-ribazole phosphatase activity
THET_RS06455	COG1984	allophanate hydrolase subunit 2
THET_RS06460	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
THET_RS06465	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
THET_RS06470	COG1914	H( )-stimulated, divalent metal cation uptake system
THET_RS06495	COG1013	pyruvate-flavodoxin oxidoreductase activity
THET_RS06500	COG0674	pyruvate-flavodoxin oxidoreductase activity
THET_RS06500	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THET_RS06520	COG1388	LysM domain
THET_RS06520	COG1705	Flagellar rod assembly protein muramidase FlgJ
THET_RS06530	COG0010	Belongs to the arginase family
THET_RS06545	COG1187	pseudouridine synthase activity
THET_RS06550	COG0445	tRNA wobble uridine modification
THET_RS06560	COG1686	Belongs to the peptidase S11 family
THET_RS06575	COG1030	water channel activity
THET_RS06580	COG1301	dicarboxylic acid transport
THET_RS06585	COG3874	Sporulation protein YtfJ
THET_RS06595	COG4086	secreted protein
THET_RS06600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THET_RS06610	COG1994	Peptidase M50
THET_RS06615	COG0517	IMP dehydrogenase activity
THET_RS06615	COG0617	tRNA 3'-terminal CCA addition
THET_RS06615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THET_RS06635	COG3360	Dodecin
THET_RS06650	COG1366	Belongs to the anti-sigma-factor antagonist family
THET_RS06655	COG1686	Belongs to the peptidase S11 family
THET_RS06660	COG4974	Belongs to the 'phage' integrase family
THET_RS06665	COG1300	Membrane
THET_RS06670	COG1379	DNA repair
THET_RS06710	COG0750	zinc metalloprotease
THET_RS06715	COG0497	DNA recombination
THET_RS06730	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
THET_RS06735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THET_RS06745	COG0142	geranyltranstransferase activity
THET_RS06760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THET_RS06770	COG1302	Protein conserved in bacteria
THET_RS06810	COG3854	ATPases associated with a variety of cellular activities
THET_RS06825	COG0006	proline dipeptidase activity
THET_RS06895	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THET_RS06905	COG1459	type II secretion system
THET_RS06915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THET_RS06920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THET_RS06925	COG0546	phosphoglycolate phosphatase activity
THET_RS06935	COG0768	penicillin binding
THET_RS06940	COG0826	peptidase U32
THET_RS06945	COG4122	O-methyltransferase activity
THET_RS06950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THET_RS06955	COG4708	membrane
THET_RS06960	COG3679	Belongs to the UPF0342 family
THET_RS06965	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
THET_RS06970	COG0735	belongs to the Fur family
THET_RS06975	COG3906	Belongs to the UPF0473 family
THET_RS06985	COG4472	Bacterial protein of unknown function (DUF965)
THET_RS06995	COG0628	permease
THET_RS07005	COG1959	2 iron, 2 sulfur cluster binding
THET_RS07015	COG3457	Alanine racemase
THET_RS07025	COG5012	cobalamin binding
THET_RS07035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THET_RS07045	COG3804	dihydrodipicolinate reductase
THET_RS07050	COG3118	belongs to the thioredoxin family
THET_RS07055	COG3118	belongs to the thioredoxin family
THET_RS07060	COG1937	Protein conserved in bacteria
THET_RS07065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THET_RS07085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THET_RS07095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THET_RS07105	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THET_RS07105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THET_RS07115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THET_RS07115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THET_RS07120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THET_RS07125	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THET_RS07170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THET_RS07180	COG0835	chemotaxis
THET_RS07190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THET_RS07210	COG1739	Uncharacterized protein family UPF0029
THET_RS07225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THET_RS07230	COG2385	sporulation resulting in formation of a cellular spore
THET_RS07250	COG1982	Orn Lys Arg decarboxylase major
THET_RS07255	COG3118	belongs to the thioredoxin family
THET_RS07260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THET_RS07265	COG0785	Cytochrome C biogenesis protein
THET_RS07285	COG2119	membrane
THET_RS07300	COG0287	Prephenate dehydrogenase
THET_RS07305	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THET_RS07310	COG0077	Prephenate dehydratase
THET_RS07310	COG1605	Chorismate mutase
THET_RS07320	COG1164	Oligoendopeptidase f
THET_RS07325	COG1760	l-serine dehydratase
THET_RS07340	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
THET_RS07345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THET_RS07350	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
THET_RS07360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THET_RS07365	COG0426	domain, Protein
THET_RS07375	COG3069	C4-dicarboxylate transmembrane transporter activity
THET_RS07395	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THET_RS07405	COG0584	glycerophosphoryl diester phosphodiesterase
THET_RS07425	COG2267	carboxylic ester hydrolase activity
THET_RS07470	COG1910	domain protein
THET_RS07475	COG0303	'Molybdopterin
THET_RS07480	COG0521	Mo-molybdopterin cofactor biosynthetic process
THET_RS07505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THET_RS07520	COG2414	aldehyde ferredoxin oxidoreductase
THET_RS07530	COG0693	protein deglycase activity
THET_RS07560	COG1132	(ABC) transporter
THET_RS07585	COG1132	(ABC) transporter
THET_RS07635	COG1132	(ABC) transporter
THET_RS07655	COG0557	exoribonuclease II activity
THET_RS07665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THET_RS07665	COG0574	Belongs to the PEP-utilizing enzyme family
THET_RS07675	COG0517	IMP dehydrogenase activity
THET_RS07680	COG0423	glycine-tRNA ligase activity
THET_RS07705	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THET_RS07715	COG1480	7TM receptor with intracellular HD hydrolase
THET_RS07720	COG1702	phosphate starvation-inducible protein PhoH
THET_RS07750	COG0537	adenosine 5'-monophosphoramidase activity
THET_RS07755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THET_RS07760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THET_RS07785	COG3344	reverse transcriptase
THET_RS07795	COG0701	Predicted permease
THET_RS07810	COG0475	glutathione-regulated potassium exporter activity
THET_RS07820	COG1482	cell wall glycoprotein biosynthetic process
THET_RS07830	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THET_RS07835	COG2384	SAM-dependent methyltransferase
THET_RS07855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THET_RS07860	COG0358	DNA primase activity
THET_RS07865	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THET_RS07870	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THET_RS07880	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THET_RS07890	COG0126	phosphoglycerate kinase activity
THET_RS07900	COG2390	Transcriptional regulator
THET_RS07910	COG1254	Belongs to the acylphosphatase family
THET_RS07915	COG0561	phosphatase activity
THET_RS07925	COG2720	vancomycin resistance protein
THET_RS07930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THET_RS07935	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THET_RS07940	COG1067	ATP-dependent peptidase activity
THET_RS07975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THET_RS07985	COG0564	pseudouridine synthase activity
THET_RS08000	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
THET_RS08005	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THET_RS08040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THET_RS08045	COG2217	Heavy metal translocating P-type atpase
THET_RS08080	COG4824	toxin secretion phage lysis holin
THET_RS08165	COG4626	Terminase
THET_RS08165	COG1802	Transcriptional regulator
THET_RS08205	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THET_RS08250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THET_RS08250	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THET_RS08345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THET_RS08355	COG3546	catalase activity
THET_RS08360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
THET_RS08365	COG1410	methionine synthase
THET_RS08365	COG0646	methionine synthase
THET_RS08370	COG0646	methionine synthase
THET_RS08370	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THET_RS08380	COG0058	SHG alpha-glucan phosphorylase activity
THET_RS08390	COG0778	Nitroreductase
THET_RS08395	COG2195	Cleaves the N-terminal amino acid of tripeptides
THET_RS08405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THET_RS08415	COG1174	glycine betaine transport
THET_RS08420	COG0517	IMP dehydrogenase activity
THET_RS08420	COG1125	glycine betaine transport
THET_RS08425	COG0471	metal ion transport
THET_RS08425	COG3273	potassium ion transport
THET_RS08430	COG0534	Mate efflux family protein
THET_RS08440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THET_RS08470	COG4109	DRTGG domain
THET_RS08475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THET_RS08490	COG0366	Alpha amylase catalytic
THET_RS08495	COG1426	Protein conserved in bacteria
THET_RS08510	COG3833	ABC-type maltose transport systems, permease component
THET_RS08515	COG1175	transmembrane transport
THET_RS08520	COG2182	Extracellular solute-binding protein
THET_RS08545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THET_RS08550	COG1752	Esterase of the alpha-beta hydrolase superfamily
THET_RS08560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THET_RS08605	COG2608	mercury ion transmembrane transporter activity
THET_RS08610	COG2217	Heavy metal translocating P-type atpase
THET_RS08625	COG0037	tRNA processing
THET_RS08630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THET_RS08635	COG2205	protein histidine kinase activity
THET_RS08640	COG0745	RESPONSE REGULATOR receiver
THET_RS08660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THET_RS08665	COG2608	mercury ion transmembrane transporter activity
THET_RS08670	COG0586	Pfam SNARE associated Golgi protein
THET_RS08680	COG5002	protein histidine kinase activity
THET_RS08680	COG5001	Diguanylate cyclase
THET_RS08680	COG3447	MASE1 domain protein
THET_RS08700	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THET_RS08700	COG2199	diguanylate cyclase activity
THET_RS08710	COG1918	ferrous iron import across plasma membrane
THET_RS08710	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THET_RS08720	COG1918	ferrous iron import across plasma membrane
THET_RS08720	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THET_RS08740	COG1120	ATPase activity
THET_RS08745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THET_RS08755	COG0446	pyridine nucleotide-disulphide oxidoreductase
THET_RS08760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THET_RS08770	COG0489	protein tyrosine kinase activity
THET_RS08775	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THET_RS08790	COG2226	methyltransferase
THET_RS08805	COG1609	Transcriptional regulator
THET_RS08810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THET_RS08815	COG1621	beta-fructofuranosidase activity
THET_RS08830	COG2182	Extracellular solute-binding protein
THET_RS08840	COG0768	penicillin binding
THET_RS08875	COG0733	neurotransmitter:sodium symporter activity
THET_RS08885	COG1917	Cupin 2, conserved barrel domain protein
THET_RS08885	COG4977	sequence-specific DNA binding
THET_RS08895	COG0395	ABC-type sugar transport system, permease component
THET_RS08900	COG1175	transmembrane transport
THET_RS08905	COG1653	transport
THET_RS08920	COG0383	alpha-mannosidase activity
THET_RS08925	COG3250	beta-galactosidase activity
THET_RS08935	COG0395	ABC-type sugar transport system, permease component
THET_RS08940	COG1175	transmembrane transport
THET_RS08945	COG1653	transport
THET_RS08955	COG1940	carbohydrate kinase activity
THET_RS08960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THET_RS08965	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THET_RS08970	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
THET_RS08985	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THET_RS08995	COG1349	DNA-binding transcription factor activity
THET_RS09000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THET_RS09020	COG0673	inositol 2-dehydrogenase activity
THET_RS09025	COG0673	inositol 2-dehydrogenase activity
THET_RS09070	COG3885	ferrous iron binding
THET_RS09070	COG2078	PFAM AMMECR1 domain protein
THET_RS09085	COG0318	PFAM AMP-dependent synthetase and ligase
THET_RS09115	COG0768	penicillin binding
THET_RS09135	COG0556	nucleotide-excision repair
THET_RS09140	COG2045	Belongs to the ComB family
THET_RS09145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THET_RS09150	COG0793	Belongs to the peptidase S41A family
THET_RS09150	COG3409	Peptidoglycan-binding domain 1 protein
THET_RS09155	COG0739	heme binding
THET_RS09160	COG2177	Part of the ABC transporter FtsEX involved in
THET_RS09165	COG2884	Cell division ATP-binding protein ftsE
THET_RS09170	COG3835	regulator
THET_RS09175	COG3842	ATPase activity
THET_RS09185	COG0019	diaminopimelate decarboxylase activity
THET_RS09200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THET_RS09220	COG0849	cell division
THET_RS09255	COG0443	Heat shock 70 kDa protein
THET_RS09265	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
THET_RS09265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THET_RS09265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THET_RS09275	COG2376	Dihydroxyacetone kinase
THET_RS09290	COG0446	pyridine nucleotide-disulphide oxidoreductase
THET_RS09305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THET_RS09310	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
THET_RS09330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THET_RS09340	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THET_RS09345	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THET_RS09360	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THET_RS09360	COG0140	phosphoribosyl-ATP diphosphatase activity
THET_RS09375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THET_RS09390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THET_RS09425	COG0673	inositol 2-dehydrogenase activity
THET_RS09440	COG1172	Belongs to the binding-protein-dependent transport system permease family
THET_RS09450	COG0673	inositol 2-dehydrogenase activity
THET_RS09460	COG1082	Xylose isomerase domain protein TIM barrel
THET_RS09485	COG1131	(ABC) transporter
THET_RS09490	COG3459	Glycosyltransferase 36 associated
THET_RS09495	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
THET_RS09495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THET_RS09500	COG0673	inositol 2-dehydrogenase activity
THET_RS09505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THET_RS09510	COG2873	o-acetylhomoserine
THET_RS09515	COG0460	homoserine dehydrogenase
THET_RS09525	COG1773	rubredoxin
THET_RS09530	COG1757	Na H antiporter
THET_RS09535	COG0205	6-phosphofructokinase activity
THET_RS09545	COG3958	Transketolase
THET_RS09550	COG3959	Transketolase, thiamine diphosphate binding domain
THET_RS09555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THET_RS09560	COG2337	Toxic component of a toxin-antitoxin (TA) module
THET_RS09570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THET_RS09580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THET_RS09580	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THET_RS09625	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
THET_RS09630	COG1793	dna ligase
THET_RS09635	COG0432	Pfam Uncharacterised protein family UPF0047
THET_RS09640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THET_RS09650	COG0204	Acyl-transferase
THET_RS09650	COG0318	PFAM AMP-dependent synthetase and ligase
THET_RS09665	COG0280	phosphate acetyltransferase
THET_RS09695	COG3426	butyrate kinase activity
THET_RS09705	COG0280	phosphate acetyltransferase
THET_RS09710	COG3426	butyrate kinase activity
THET_RS09720	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
THET_RS09740	COG1305	Transglutaminase-like
THET_RS09750	COG0714	Associated with various cellular activities
THET_RS09755	COG0546	phosphoglycolate phosphatase activity
THET_RS09765	COG1705	Flagellar rod assembly protein muramidase FlgJ
THET_RS09765	COG1388	LysM domain
THET_RS09790	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THET_RS09800	COG0651	ATP synthesis coupled electron transport
THET_RS09805	COG0651	ATP synthesis coupled electron transport
THET_RS09825	COG1320	monovalent cation:proton antiporter activity
THET_RS09835	COG1863	multisubunit Na H antiporter MnhE subunit
THET_RS09840	COG1115	amino acid carrier protein
THET_RS09845	COG1966	Carbon starvation protein
THET_RS09865	COG2033	superoxide reductase activity
THET_RS09945	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THET_RS09950	COG1122	ATPase activity
THET_RS09955	COG1122	ATPase activity
THET_RS09990	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THET_RS10010	COG0201	protein transport
THET_RS10075	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THET_RS10115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THET_RS10130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THET_RS10135	COG1358	cellular component organization or biogenesis
THET_RS10170	COG0250	Participates in transcription elongation, termination and antitermination
THET_RS10175	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THET_RS10180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THET_RS10190	COG1595	DNA-templated transcription, initiation
THET_RS10195	COG3688	RNA-binding protein containing a PIN domain
THET_RS10200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THET_RS10215	COG1045	serine acetyltransferase
THET_RS10235	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THET_RS10245	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THET_RS10250	COG4956	integral membrane protein (PIN domain superfamily)
THET_RS10260	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THET_RS10265	COG0542	response to heat
THET_RS10270	COG3869	Catalyzes the specific phosphorylation of arginine residues in
THET_RS10275	COG3880	PFAM UvrB UvrC protein
THET_RS10295	COG0281	malic enzyme
THET_RS10300	COG3344	reverse transcriptase
THET_RS10305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THET_RS10310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THET_RS10315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THET_RS10320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THET_RS10320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THET_RS10320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THET_RS10325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THET_RS10325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THET_RS10325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THET_RS10330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THET_RS10330	COG3711	transcriptional antiterminator
THET_RS10365	COG0823	Involved in the tonB-independent uptake of proteins
THET_RS10365	COG1506	peptidase
THET_RS10365	COG4946	Tricorn protease homolog
THET_RS10375	COG0720	synthase
THET_RS10380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THET_RS10385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THET_RS10405	COG5322	oxidoreductase activity
THET_RS10405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THET_RS10430	COG0697	spore germination
THET_RS10435	COG0531	amino acid
THET_RS10445	COG4684	Psort location CytoplasmicMembrane, score
THET_RS10450	COG5016	pyruvate
THET_RS10450	COG0511	ligase activity, forming carbon-carbon bonds
THET_RS10460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THET_RS10475	COG3852	Histidine kinase
THET_RS10485	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THET_RS10490	COG0037	tRNA processing
THET_RS10495	COG2208	phosphoserine phosphatase activity
THET_RS10505	COG0697	spore germination
THET_RS10520	COG1131	(ABC) transporter
THET_RS10540	COG1063	alcohol dehydrogenase
THET_RS10565	COG3300	MHYT domain
THET_RS10565	COG5001	Diguanylate cyclase
THET_RS10570	COG2217	Heavy metal translocating P-type atpase
THET_RS10585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THET_RS10590	COG2217	Heavy metal translocating P-type atpase
THET_RS10605	COG2205	protein histidine kinase activity
THET_RS10610	COG0745	RESPONSE REGULATOR receiver
THET_RS10625	COG2801	Transposase and inactivated derivatives
THET_RS10640	COG3387	PFAM Glycoside hydrolase 15-related
THET_RS10650	COG0395	ABC-type sugar transport system, permease component
THET_RS10660	COG1175	transmembrane transport
THET_RS10665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THET_RS10670	COG1940	carbohydrate kinase activity
THET_RS10685	COG3344	reverse transcriptase
THET_RS10690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
THET_RS10700	COG3300	MHYT domain
THET_RS10700	COG5001	Diguanylate cyclase
THET_RS10830	COG4962	Type ii secretion system protein e
THET_RS10855	COG0739	heme binding
THET_RS10930	COG1396	sequence-specific DNA binding
THET_RS10970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THET_RS10970	COG0248	Ppx GppA phosphatase
THET_RS10975	COG1098	S1 RNA binding domain
THET_RS11010	COG2385	sporulation resulting in formation of a cellular spore
THET_RS11015	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THET_RS11020	COG0776	regulation of translation
THET_RS11025	COG3956	TIGRFAM MazG family protein
THET_RS11035	COG2814	Major facilitator Superfamily
THET_RS11040	COG1160	GTP binding
THET_RS11045	COG1027	Aspartate ammonia-lyase
THET_RS11050	COG5002	protein histidine kinase activity
THET_RS11055	COG2033	superoxide reductase activity
THET_RS11065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THET_RS11095	COG0142	geranyltranstransferase activity
THET_RS11115	COG1528	Iron-storage protein
THET_RS11130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THET_RS11150	COG0505	Belongs to the CarA family
THET_RS11155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THET_RS11165	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THET_RS11200	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
THET_RS11200	COG0493	'glutamate synthase
THET_RS11205	COG1796	DNA polymerase
THET_RS11205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THET_RS11215	COG1131	(ABC) transporter
THET_RS11235	COG1595	DNA-templated transcription, initiation
THET_RS11290	COG0671	phosphoesterase, PA-phosphatase related
THET_RS11295	COG3859	Proton-coupled thiamine transporter YuaJ
THET_RS11300	COG1132	(ABC) transporter
THET_RS11310	COG1846	Transcriptional regulator
THET_RS11320	COG1012	belongs to the aldehyde dehydrogenase family
THET_RS11320	COG1454	alcohol dehydrogenase
THET_RS11330	COG0667	Aldo Keto reductase
THET_RS11340	COG4166	transmembrane transport
THET_RS11345	COG0601	transmembrane transport
THET_RS11350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THET_RS11355	COG0444	Belongs to the ABC transporter superfamily
THET_RS11360	COG4608	Belongs to the ABC transporter superfamily
THET_RS11380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THET_RS11390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THET_RS11395	COG0018	arginyl-trna synthetase
THET_RS11415	COG2959	enzyme of heme biosynthesis
THET_RS11435	COG0531	amino acid
THET_RS11440	COG0697	spore germination
THET_RS11455	COG1802	Transcriptional regulator
THET_RS11465	COG1388	LysM domain
THET_RS11470	COG4466	Protein conserved in bacteria
THET_RS11480	COG2002	toxin-antitoxin pair type II binding
THET_RS11485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THET_RS11490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THET_RS11505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THET_RS11510	COG5002	protein histidine kinase activity
THET_RS11515	COG0745	RESPONSE REGULATOR receiver
THET_RS11520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THET_RS11525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THET_RS11535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THET_RS11540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THET_RS11545	COG1609	Transcriptional regulator
THET_RS11555	COG0071	Belongs to the small heat shock protein (HSP20) family
THET_RS11570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THET_RS11570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THET_RS11570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THET_RS11580	COG1349	DNA-binding transcription factor activity
THET_RS11590	COG0504	CTP synthase activity
THET_RS11600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THET_RS11605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THET_RS11615	COG0083	homoserine kinase activity
THET_RS11620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THET_RS11625	COG0460	homoserine dehydrogenase
THET_RS11635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
THET_RS11645	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THET_RS11650	COG1518	maintenance of DNA repeat elements
THET_RS11660	COG3340	Belongs to the peptidase S51 family
THET_RS11705	COG0822	iron-sulfur transferase activity
THET_RS11710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THET_RS11720	COG0719	Fe-S assembly protein
THET_RS11725	COG0396	ATPase activity
THET_RS11730	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THET_RS11750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THET_RS11765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THET_RS11770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THET_RS11780	COG0739	heme binding
THET_RS11790	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THET_RS11795	COG0308	aminopeptidase N
THET_RS11810	COG0658	competence protein
THET_RS11810	COG2333	competence protein COMEC
THET_RS11835	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
THET_RS11840	COG0840	transmembrane signaling receptor activity
THET_RS11850	COG0446	pyridine nucleotide-disulphide oxidoreductase
THET_RS11885	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
THET_RS11890	COG1527	subunit (C
THET_RS11900	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THET_RS11905	COG1269	ATP hydrolysis coupled proton transport
THET_RS12005	COG0305	Participates in initiation and elongation during chromosome replication
THET_RS12015	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
THET_RS12035	COG0629	single-stranded DNA binding
THET_RS12045	COG4481	Protein conserved in bacteria
THET_RS12050	COG0668	transmembrane transport
THET_RS12060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THET_RS12060	COG0189	ligase activity
THET_RS12065	COG4242	Belongs to the peptidase S51 family
THET_RS12070	COG1597	lipid kinase activity
THET_RS12080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THET_RS12085	COG1475	DNA binding
THET_RS12090	COG1192	Involved in chromosome partitioning
THET_RS12120	COG1847	R3H domain protein
THET_RS12125	COG0706	membrane insertase activity