locus-tag	class	description
THEWI_RS00010	COG0592	DNA-directed DNA polymerase activity
THEWI_RS00015	COG2501	S4 domain
THEWI_RS00045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEWI_RS00050	COG0187	DNA topoisomerase II activity
THEWI_RS00055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THEWI_RS00060	COG1902	pentaerythritol trinitrate reductase activity
THEWI_RS00065	COG0440	acetolactate synthase activity
THEWI_RS00075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEWI_RS00085	COG0066	3-isopropylmalate dehydratase activity
THEWI_RS00090	COG0473	3-isopropylmalate dehydrogenase activity
THEWI_RS00095	COG0129	dihydroxy-acid dehydratase activity
THEWI_RS00100	COG0028	Belongs to the TPP enzyme family
THEWI_RS00120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THEWI_RS00125	COG0628	permease
THEWI_RS00150	COG1316	TRANSCRIPTIONal
THEWI_RS00200	COG0651	ATP synthesis coupled electron transport
THEWI_RS00205	COG0651	ATP synthesis coupled electron transport
THEWI_RS00210	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THEWI_RS00215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEWI_RS00220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEWI_RS00220	COG0649	NAD binding
THEWI_RS00225	COG0649	NAD binding
THEWI_RS00245	COG1966	Carbon starvation protein
THEWI_RS00250	COG3344	reverse transcriptase
THEWI_RS00285	COG2199	diguanylate cyclase activity
THEWI_RS00285	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEWI_RS00290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THEWI_RS00295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THEWI_RS00300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THEWI_RS00305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THEWI_RS00315	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEWI_RS00360	COG1028	Short-chain dehydrogenase reductase Sdr
THEWI_RS00365	COG1187	pseudouridine synthase activity
THEWI_RS00370	COG1609	Transcriptional regulator
THEWI_RS00375	COG1653	transport
THEWI_RS00385	COG0395	ABC-type sugar transport system, permease component
THEWI_RS00395	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THEWI_RS00400	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THEWI_RS00405	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THEWI_RS00425	COG1028	Short-chain dehydrogenase reductase Sdr
THEWI_RS00435	COG1511	domain protein
THEWI_RS00445	COG0037	tRNA processing
THEWI_RS00450	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
THEWI_RS00450	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
THEWI_RS00460	COG1573	uracil-dna glycosylase
THEWI_RS00490	COG0425	Belongs to the sulfur carrier protein TusA family
THEWI_RS00495	COG2391	methyltransferase activity
THEWI_RS00515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THEWI_RS00520	COG0509	glycine decarboxylation via glycine cleavage system
THEWI_RS00535	COG0519	Catalyzes the synthesis of GMP from XMP
THEWI_RS00545	COG1982	Orn Lys Arg decarboxylase major
THEWI_RS00555	COG3870	Protein conserved in bacteria
THEWI_RS00565	COG0470	DNA polymerase III
THEWI_RS00570	COG1774	PSP1 C-terminal conserved region
THEWI_RS00580	COG0730	response to heat
THEWI_RS00585	COG3464	Transposase
THEWI_RS00595	COG2235	arginine
THEWI_RS00600	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
THEWI_RS00605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THEWI_RS00610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THEWI_RS00615	COG2002	toxin-antitoxin pair type II binding
THEWI_RS00620	COG2715	membrane protein required for spore maturation
THEWI_RS00625	COG0700	Nucleoside recognition
THEWI_RS00630	COG0617	tRNA 3'-terminal CCA addition
THEWI_RS00640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEWI_RS00640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEWI_RS00645	COG0084	hydrolase, TatD family'
THEWI_RS00650	COG3583	domain protein
THEWI_RS00650	COG3584	3D domain protein
THEWI_RS00655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THEWI_RS00675	COG4447	cellulose binding
THEWI_RS00680	COG1191	sigma factor activity
THEWI_RS00685	COG2151	metal-sulfur cluster biosynthetic enzyme
THEWI_RS00685	COG0489	protein tyrosine kinase activity
THEWI_RS00700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THEWI_RS00705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THEWI_RS00705	COG2111	Na H antiporter
THEWI_RS00710	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THEWI_RS00715	COG3260	NADH ubiquinone oxidoreductase 20
THEWI_RS00730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEWI_RS00735	COG0375	protein maturation
THEWI_RS00745	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THEWI_RS00750	COG0298	carbon dioxide binding
THEWI_RS00755	COG0409	Hydrogenase expression formation protein
THEWI_RS00765	COG0745	RESPONSE REGULATOR receiver
THEWI_RS00775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THEWI_RS00790	COG3872	metal-dependent enzyme
THEWI_RS00795	COG2890	protein-(glutamine-N5) methyltransferase activity
THEWI_RS00805	COG0428	transporter
THEWI_RS00810	COG0009	L-threonylcarbamoyladenylate synthase
THEWI_RS00815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THEWI_RS00820	COG0698	ribose 5-phosphate isomerase
THEWI_RS00835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THEWI_RS00840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THEWI_RS00855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THEWI_RS00870	COG0686	Belongs to the AlaDH PNT family
THEWI_RS00895	COG1361	Conserved repeat domain
THEWI_RS00905	COG2385	sporulation resulting in formation of a cellular spore
THEWI_RS00915	COG1609	Transcriptional regulator
THEWI_RS00925	COG4786	Flagellar basal body rod
THEWI_RS00940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THEWI_RS00955	COG1496	oxidoreductase activity
THEWI_RS00970	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEWI_RS00970	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEWI_RS00975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEWI_RS00975	COG2213	PTS system mannitol-specific
THEWI_RS00995	COG1063	alcohol dehydrogenase
THEWI_RS01005	COG3414	Phosphotransferase system galactitol-specific IIB component
THEWI_RS01010	COG3775	system Galactitol-specific IIC component
THEWI_RS01015	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
THEWI_RS01045	COG4948	Mandelate Racemase Muconate Lactonizing
THEWI_RS01055	COG0800	Aldolase
THEWI_RS01060	COG2814	Major facilitator Superfamily
THEWI_RS01070	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEWI_RS01070	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEWI_RS01075	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THEWI_RS01080	COG3715	PTS system
THEWI_RS01085	COG3716	PTS system mannose fructose sorbose family IID component
THEWI_RS01090	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEWI_RS01105	COG2222	sugar isomerase
THEWI_RS01110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THEWI_RS01115	COG0569	domain protein
THEWI_RS01120	COG1082	Xylose isomerase domain protein TIM barrel
THEWI_RS01125	COG2115	Belongs to the xylose isomerase family
THEWI_RS01130	COG1070	Carbohydrate kinase
THEWI_RS01135	COG1653	transport
THEWI_RS01145	COG0395	ABC-type sugar transport system, permease component
THEWI_RS01155	COG2723	6-phospho-beta-galactosidase activity
THEWI_RS01170	COG1472	Belongs to the glycosyl hydrolase 3 family
THEWI_RS01190	COG1297	OPT oligopeptide transporter protein
THEWI_RS01200	COG0436	Aminotransferase
THEWI_RS01205	COG1522	sequence-specific DNA binding
THEWI_RS01210	COG3464	Transposase
THEWI_RS01220	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THEWI_RS01220	COG1918	ferrous iron import across plasma membrane
THEWI_RS01235	COG1122	ATPase activity
THEWI_RS01240	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THEWI_RS01245	COG0310	cobalt ion transport
THEWI_RS01250	COG0310	cobalt ion transport
THEWI_RS01255	COG0864	Transcriptional regulator
THEWI_RS01260	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
THEWI_RS01270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THEWI_RS01275	COG0534	Mate efflux family protein
THEWI_RS01280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THEWI_RS01285	COG1136	(ABC) transporter
THEWI_RS01290	COG1136	(ABC) transporter
THEWI_RS01290	COG0577	efflux transmembrane transporter activity
THEWI_RS01320	COG1074	ATP-dependent DNA helicase activity
THEWI_RS01340	COG0450	alkyl hydroperoxide reductase
THEWI_RS01355	COG3464	Transposase
THEWI_RS01370	COG0297	glycogen (starch) synthase activity
THEWI_RS01375	COG0586	Pfam SNARE associated Golgi protein
THEWI_RS01420	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THEWI_RS01425	COG1980	fructose-bisphosphate aldolase activity
THEWI_RS01435	COG2972	Histidine kinase
THEWI_RS01440	COG2197	response regulator
THEWI_RS01445	COG4213	ABC transporter substrate-binding protein
THEWI_RS01450	COG4213	ABC transporter substrate-binding protein
THEWI_RS01455	COG1129	ABC transporter
THEWI_RS01460	COG4214	carbohydrate transport
THEWI_RS01470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THEWI_RS01485	COG0095	Lipoate-protein ligase
THEWI_RS01490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THEWI_RS01500	COG0436	Aminotransferase
THEWI_RS01505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEWI_RS01510	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THEWI_RS01525	COG3959	Transketolase, thiamine diphosphate binding domain
THEWI_RS01530	COG3958	Transketolase
THEWI_RS01540	COG0205	6-phosphofructokinase activity
THEWI_RS01565	COG3732	PTS system glucitol sorbitol-specific
THEWI_RS01585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THEWI_RS01595	COG1263	PTS System
THEWI_RS01595	COG2190	(PTS) system
THEWI_RS01595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THEWI_RS01600	COG2190	(PTS) system
THEWI_RS01625	COG3464	Transposase
THEWI_RS01640	COG1979	alcohol dehydrogenase
THEWI_RS01660	COG0640	Transcriptional regulator
THEWI_RS01690	COG3464	Transposase
THEWI_RS01700	COG3464	Transposase
THEWI_RS01715	COG1309	transcriptional regulator
THEWI_RS01730	COG1924	4 iron, 4 sulfur cluster binding
THEWI_RS01735	COG1230	cation diffusion facilitator family transporter
THEWI_RS01745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THEWI_RS01750	COG0390	transport system, permease component
THEWI_RS01755	COG0495	leucyl-tRNA aminoacylation
THEWI_RS01760	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
THEWI_RS01770	COG1522	sequence-specific DNA binding
THEWI_RS01770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THEWI_RS01775	COG2313	pseudouridylate synthase activity
THEWI_RS01790	COG0306	phosphate transporter
THEWI_RS01805	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEWI_RS01805	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEWI_RS01815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THEWI_RS01820	COG1486	melibiose metabolic process
THEWI_RS01830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THEWI_RS01835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THEWI_RS01840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THEWI_RS01845	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
THEWI_RS01850	COG1447	Phosphotransferase system cellobiose-specific component IIA
THEWI_RS01860	COG2414	aldehyde ferredoxin oxidoreductase
THEWI_RS01880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THEWI_RS01905	COG0521	Mo-molybdopterin cofactor biosynthetic process
THEWI_RS01910	COG0303	'Molybdopterin
THEWI_RS01915	COG1910	domain protein
THEWI_RS01935	COG2723	6-phospho-beta-galactosidase activity
THEWI_RS01940	COG2213	PTS system mannitol-specific
THEWI_RS01945	COG3711	transcriptional antiterminator
THEWI_RS01945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEWI_RS01960	COG0737	Belongs to the 5'-nucleotidase family
THEWI_RS01965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THEWI_RS01970	COG0730	response to heat
THEWI_RS01995	COG0601	transmembrane transport
THEWI_RS02000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THEWI_RS02005	COG0444	Belongs to the ABC transporter superfamily
THEWI_RS02015	COG3250	beta-galactosidase activity
THEWI_RS02020	COG2723	6-phospho-beta-galactosidase activity
THEWI_RS02025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THEWI_RS02030	COG1121	(ABC) transporter
THEWI_RS02035	COG0803	Belongs to the bacterial solute-binding protein 9 family
THEWI_RS02040	COG0735	belongs to the Fur family
THEWI_RS02045	COG0714	Associated with various cellular activities
THEWI_RS02060	COG1704	LemA family
THEWI_RS02065	COG0583	DNA-binding transcription factor activity
THEWI_RS02085	COG0084	hydrolase, TatD family'
THEWI_RS02095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THEWI_RS02100	COG0822	iron-sulfur transferase activity
THEWI_RS02115	COG0116	Belongs to the methyltransferase superfamily
THEWI_RS02120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THEWI_RS02125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THEWI_RS02130	COG1120	ATPase activity
THEWI_RS02135	COG1797	cobyrinic acid a,c-diamide synthase activity
THEWI_RS02160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THEWI_RS02170	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
THEWI_RS02200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THEWI_RS02205	COG0181	hydroxymethylbilane synthase activity
THEWI_RS02215	COG0113	porphobilinogen synthase activity
THEWI_RS02220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THEWI_RS02220	COG1648	precorrin-2 dehydrogenase activity
THEWI_RS02235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THEWI_RS02240	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
THEWI_RS02245	COG1122	ATPase activity
THEWI_RS02260	COG0330	HflC and HflK could
THEWI_RS02280	COG3842	ATPase activity
THEWI_RS02420	COG3344	reverse transcriptase
THEWI_RS02450	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEWI_RS02450	COG2199	diguanylate cyclase activity
THEWI_RS02460	COG0840	transmembrane signaling receptor activity
THEWI_RS02465	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
THEWI_RS02475	COG1228	amidohydrolase
THEWI_RS02505	COG1653	transport
THEWI_RS02510	COG2972	Histidine kinase
THEWI_RS02515	COG4753	response regulator
THEWI_RS02515	COG2207	Transcriptional regulator
THEWI_RS02520	COG3404	Formiminotransferase-cyclodeaminase
THEWI_RS02525	COG1744	ABC transporter substrate-binding protein PnrA-like
THEWI_RS02530	COG3845	ABC transporter
THEWI_RS02535	COG4603	Belongs to the binding-protein-dependent transport system permease family
THEWI_RS02540	COG1079	Belongs to the binding-protein-dependent transport system permease family
THEWI_RS02545	COG2188	Transcriptional regulator
THEWI_RS02575	COG2190	(PTS) system
THEWI_RS02575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THEWI_RS02575	COG1263	PTS System
THEWI_RS02580	COG2190	(PTS) system
THEWI_RS02585	COG3711	transcriptional antiterminator
THEWI_RS02590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEWI_RS02630	COG2081	HI0933 family
THEWI_RS02655	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
THEWI_RS02665	COG2323	membrane
THEWI_RS02670	COG0561	phosphatase activity
THEWI_RS02675	COG1609	Transcriptional regulator
THEWI_RS02680	COG0745	RESPONSE REGULATOR receiver
THEWI_RS02685	COG5002	protein histidine kinase activity
THEWI_RS02725	COG1592	Rubrerythrin
THEWI_RS02730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THEWI_RS02740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THEWI_RS02745	COG1040	competence protein
THEWI_RS02765	COG1256	bacterial-type flagellum assembly
THEWI_RS02765	COG4786	Flagellar basal body rod
THEWI_RS02770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THEWI_RS02780	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
THEWI_RS02785	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THEWI_RS02790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THEWI_RS02840	COG0457	Tetratricopeptide repeat
THEWI_RS02840	COG0463	Glycosyl transferase, family 2
THEWI_RS02845	COG0367	asparagine synthase
THEWI_RS02860	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THEWI_RS02875	COG0840	transmembrane signaling receptor activity
THEWI_RS02885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THEWI_RS02890	COG0765	amino acid transport
THEWI_RS02920	COG1827	regulation of RNA biosynthetic process
THEWI_RS02930	COG0653	protein targeting
THEWI_RS02935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THEWI_RS02950	COG0398	Pfam SNARE associated Golgi protein
THEWI_RS02960	COG2235	arginine
THEWI_RS02965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THEWI_RS02970	COG0549	Belongs to the carbamate kinase family
THEWI_RS02980	COG0802	atpase or kinase
THEWI_RS02985	COG1214	PFAM Peptidase M22, glycoprotease
THEWI_RS02995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THEWI_RS03010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THEWI_RS03025	COG1024	Enoyl-CoA hydratase
THEWI_RS03030	COG1960	acyl-CoA dehydrogenase activity
THEWI_RS03035	COG2086	electron transfer activity
THEWI_RS03040	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THEWI_RS03045	COG1250	3-hydroxyacyl-CoA dehydrogenase
THEWI_RS03055	COG0183	Belongs to the thiolase family
THEWI_RS03065	COG2030	dehydratase
THEWI_RS03095	COG2267	carboxylic ester hydrolase activity
THEWI_RS03100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THEWI_RS03105	COG0427	acetyl-CoA hydrolase
THEWI_RS03115	COG0596	Alpha beta hydrolase
THEWI_RS03125	COG0840	transmembrane signaling receptor activity
THEWI_RS03130	COG3426	butyrate kinase activity
THEWI_RS03140	COG3279	Response regulator of the LytR AlgR family
THEWI_RS03145	COG3290	protein histidine kinase activity
THEWI_RS03165	COG0493	'glutamate synthase
THEWI_RS03170	COG0424	maF-like protein
THEWI_RS03175	COG1811	Na channel or pump
THEWI_RS03185	COG1404	Belongs to the peptidase S8 family
THEWI_RS03220	COG3344	reverse transcriptase
THEWI_RS03270	COG3344	reverse transcriptase
THEWI_RS03275	COG0516	GMP reductase activity
THEWI_RS03275	COG0517	IMP dehydrogenase activity
THEWI_RS03280	COG0519	Catalyzes the synthesis of GMP from XMP
THEWI_RS03280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THEWI_RS03285	COG2252	PERMEase
THEWI_RS03290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THEWI_RS03300	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THEWI_RS03305	COG0047	phosphoribosylformylglycinamidine synthase activity
THEWI_RS03310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THEWI_RS03315	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THEWI_RS03320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THEWI_RS03325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THEWI_RS03335	COG0151	Belongs to the GarS family
THEWI_RS03340	COG2226	methyltransferase
THEWI_RS03345	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THEWI_RS03350	COG1473	amidohydrolase
THEWI_RS03355	COG2244	polysaccharide biosynthetic process
THEWI_RS03365	COG3711	transcriptional antiterminator
THEWI_RS03375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THEWI_RS03380	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THEWI_RS03385	COG1447	Phosphotransferase system cellobiose-specific component IIA
THEWI_RS03390	COG4496	protein, YerC YecD
THEWI_RS03395	COG0210	DNA helicase
THEWI_RS03415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THEWI_RS03425	COG4166	transmembrane transport
THEWI_RS03435	COG0601	transmembrane transport
THEWI_RS03440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THEWI_RS03445	COG0444	Belongs to the ABC transporter superfamily
THEWI_RS03465	COG0860	N-Acetylmuramoyl-L-alanine amidase
THEWI_RS03465	COG2247	cell wall binding repeat
THEWI_RS03530	COG0850	regulation of cytokinetic process
THEWI_RS03545	COG0004	ammonium transporteR
THEWI_RS03550	COG0347	Belongs to the P(II) protein family
THEWI_RS03555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THEWI_RS03560	COG0067	glutamate synthase
THEWI_RS03570	COG0437	4 iron, 4 sulfur cluster binding
THEWI_RS03595	COG0351	phosphomethylpyrimidine kinase
THEWI_RS03600	COG0352	thiamine-phosphate diphosphorylase activity
THEWI_RS03605	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
THEWI_RS03620	COG0704	Plays a role in the regulation of phosphate uptake
THEWI_RS03625	COG0686	Belongs to the AlaDH PNT family
THEWI_RS03660	COG3464	Transposase
THEWI_RS03680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THEWI_RS03685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THEWI_RS03700	COG0356	it plays a direct role in the translocation of protons across the membrane
THEWI_RS03705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THEWI_RS03710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THEWI_RS03715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THEWI_RS03720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THEWI_RS03725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THEWI_RS03730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THEWI_RS03735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THEWI_RS03745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THEWI_RS03745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THEWI_RS03755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THEWI_RS03760	COG1116	anion transmembrane transporter activity
THEWI_RS03830	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
THEWI_RS03835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THEWI_RS03880	COG3547	Transposase (IS116 IS110 IS902 family)
THEWI_RS03885	COG0438	transferase activity, transferring glycosyl groups
THEWI_RS03895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THEWI_RS03910	COG1091	dTDP-4-dehydrorhamnose reductase activity
THEWI_RS03985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THEWI_RS03985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THEWI_RS04075	COG1704	LemA family
THEWI_RS04080	COG0622	Phosphoesterase
THEWI_RS04085	COG4989	oxidoreductase activity
THEWI_RS04115	COG1598	PFAM Uncharacterised protein family UPF0150
THEWI_RS04160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THEWI_RS04170	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
THEWI_RS04175	COG1607	acyl-coa hydrolase
THEWI_RS04180	COG3246	L-lysine catabolic process to acetate
THEWI_RS04185	COG0604	alcohol dehydrogenase
THEWI_RS04200	COG1193	negative regulation of DNA recombination
THEWI_RS04205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
THEWI_RS04210	COG5012	cobalamin binding
THEWI_RS04215	COG0531	amino acid
THEWI_RS04220	COG0250	Participates in transcription elongation, termination and antitermination
THEWI_RS04230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THEWI_RS04235	COG3944	biosynthesis protein
THEWI_RS04240	COG0489	protein tyrosine kinase activity
THEWI_RS04250	COG1316	TRANSCRIPTIONal
THEWI_RS04265	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THEWI_RS04275	COG2814	Major facilitator Superfamily
THEWI_RS04290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THEWI_RS04295	COG0671	phosphoesterase, PA-phosphatase related
THEWI_RS04310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THEWI_RS04315	COG0840	transmembrane signaling receptor activity
THEWI_RS04325	COG1691	(AIR) carboxylase
THEWI_RS04330	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THEWI_RS04335	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THEWI_RS04345	COG0745	RESPONSE REGULATOR receiver
THEWI_RS04370	COG0525	valine-tRNA ligase activity
THEWI_RS04380	COG0285	dihydrofolate synthase activity
THEWI_RS04415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THEWI_RS04420	COG1609	Transcriptional regulator
THEWI_RS04430	COG1653	transport
THEWI_RS04435	COG1175	transmembrane transport
THEWI_RS04440	COG0395	ABC-type sugar transport system, permease component
THEWI_RS04445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THEWI_RS04465	COG0395	ABC-type sugar transport system, permease component
THEWI_RS04480	COG1404	Belongs to the peptidase S8 family
THEWI_RS04485	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEWI_RS04485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEWI_RS04490	COG3773	Cell wall hydrolase
THEWI_RS04490	COG3409	Peptidoglycan-binding domain 1 protein
THEWI_RS04505	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
THEWI_RS04515	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THEWI_RS04525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THEWI_RS04535	COG1132	(ABC) transporter
THEWI_RS04540	COG1132	(ABC) transporter
THEWI_RS04560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
THEWI_RS04580	COG0739	heme binding
THEWI_RS04600	COG2986	histidine ammonia-lyase
THEWI_RS04615	COG1131	(ABC) transporter
THEWI_RS04625	COG0616	signal peptide processing
THEWI_RS04650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THEWI_RS04655	COG4475	Protein of unknown function (DUF436)
THEWI_RS04695	COG1983	PspC domain protein
THEWI_RS04720	COG1966	Carbon starvation protein
THEWI_RS04725	COG3279	Response regulator of the LytR AlgR family
THEWI_RS04730	COG3275	phosphorelay sensor kinase activity
THEWI_RS04735	COG1595	DNA-templated transcription, initiation
THEWI_RS04750	COG0237	dephospho-CoA kinase activity
THEWI_RS04755	COG0741	lytic transglycosylase activity
THEWI_RS04775	COG0791	NLP P60 protein
THEWI_RS04780	COG1217	gtp-binding protein TYPA
THEWI_RS04790	COG0741	lytic transglycosylase activity
THEWI_RS04810	COG2878	Part of a membrane complex involved in electron transport
THEWI_RS04830	COG4191	Histidine kinase
THEWI_RS04830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THEWI_RS04860	COG2003	Belongs to the UPF0758 family
THEWI_RS04865	COG1077	Cell shape determining protein MreB Mrl
THEWI_RS04890	COG2894	cell division
THEWI_RS04900	COG0772	Belongs to the SEDS family
THEWI_RS04910	COG0739	heme binding
THEWI_RS04915	COG1994	Peptidase M50
THEWI_RS04915	COG0517	IMP dehydrogenase activity
THEWI_RS04930	COG1530	ribonuclease E activity
THEWI_RS04940	COG4708	membrane
THEWI_RS04945	COG3464	Transposase
THEWI_RS04950	COG3464	Transposase
THEWI_RS04990	COG1713	HD superfamily hydrolase involved in NAD metabolism
THEWI_RS04995	COG1316	TRANSCRIPTIONal
THEWI_RS05020	COG0367	asparagine synthase
THEWI_RS05025	COG1686	Belongs to the peptidase S11 family
THEWI_RS05030	COG1596	polysaccharide export
THEWI_RS05030	COG1555	photosystem II stabilization
THEWI_RS05040	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THEWI_RS05065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THEWI_RS05070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THEWI_RS05085	COG4720	Psort location CytoplasmicMembrane, score
THEWI_RS05100	COG1234	tRNA 3'-trailer cleavage
THEWI_RS05105	COG2333	competence protein COMEC
THEWI_RS05105	COG0658	competence protein
THEWI_RS05115	COG0268	Binds directly to 16S ribosomal RNA
THEWI_RS05125	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THEWI_RS05155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THEWI_RS05160	COG1420	regulation of RNA biosynthetic process
THEWI_RS05165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THEWI_RS05170	COG0443	Heat shock 70 kDa protein
THEWI_RS05175	COG0484	heat shock protein binding
THEWI_RS05180	COG2264	protein methyltransferase activity
THEWI_RS05190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEWI_RS05195	COG0537	adenosine 5'-monophosphoramidase activity
THEWI_RS05225	COG1702	phosphate starvation-inducible protein PhoH
THEWI_RS05230	COG1480	7TM receptor with intracellular HD hydrolase
THEWI_RS05240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THEWI_RS05270	COG0423	glycine-tRNA ligase activity
THEWI_RS05275	COG0517	IMP dehydrogenase activity
THEWI_RS05285	COG0574	Belongs to the PEP-utilizing enzyme family
THEWI_RS05285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEWI_RS05295	COG0557	exoribonuclease II activity
THEWI_RS05340	COG0693	protein deglycase activity
THEWI_RS05355	COG2267	carboxylic ester hydrolase activity
THEWI_RS05385	COG3344	reverse transcriptase
THEWI_RS05400	COG0584	glycerophosphoryl diester phosphodiesterase
THEWI_RS05410	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THEWI_RS05415	COG1968	undecaprenyl-diphosphatase activity
THEWI_RS05435	COG3069	C4-dicarboxylate transmembrane transporter activity
THEWI_RS05445	COG0426	domain, Protein
THEWI_RS05450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THEWI_RS05460	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
THEWI_RS05465	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THEWI_RS05470	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
THEWI_RS05485	COG1760	l-serine dehydratase
THEWI_RS05490	COG1164	Oligoendopeptidase f
THEWI_RS05495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THEWI_RS05500	COG1605	Chorismate mutase
THEWI_RS05500	COG0077	Prephenate dehydratase
THEWI_RS05505	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THEWI_RS05510	COG0287	Prephenate dehydrogenase
THEWI_RS05520	COG0745	RESPONSE REGULATOR receiver
THEWI_RS05525	COG5002	protein histidine kinase activity
THEWI_RS05525	COG3850	Histidine kinase
THEWI_RS05535	COG2119	membrane
THEWI_RS05550	COG0745	RESPONSE REGULATOR receiver
THEWI_RS05555	COG2205	protein histidine kinase activity
THEWI_RS05585	COG0363	glucosamine-6-phosphate deaminase activity
THEWI_RS05600	COG1136	(ABC) transporter
THEWI_RS05605	COG0785	Cytochrome C biogenesis protein
THEWI_RS05610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THEWI_RS05615	COG3118	belongs to the thioredoxin family
THEWI_RS05625	COG1982	Orn Lys Arg decarboxylase major
THEWI_RS05680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THEWI_RS05695	COG1739	Uncharacterized protein family UPF0029
THEWI_RS05720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THEWI_RS05730	COG0835	chemotaxis
THEWI_RS05745	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THEWI_RS05765	COG2385	sporulation resulting in formation of a cellular spore
THEWI_RS05765	COG2247	cell wall binding repeat
THEWI_RS05775	COG0343	queuine tRNA-ribosyltransferase activity
THEWI_RS05795	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THEWI_RS05800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THEWI_RS05805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THEWI_RS05815	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THEWI_RS05815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THEWI_RS05820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THEWI_RS05825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THEWI_RS05835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEWI_RS05840	COG0577	efflux transmembrane transporter activity
THEWI_RS05845	COG1136	(ABC) transporter
THEWI_RS05850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THEWI_RS05855	COG1846	Transcriptional regulator
THEWI_RS05865	COG0124	histidyl-tRNA synthetase
THEWI_RS05870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THEWI_RS05875	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THEWI_RS05880	COG1937	Protein conserved in bacteria
THEWI_RS05885	COG3118	belongs to the thioredoxin family
THEWI_RS05890	COG3118	belongs to the thioredoxin family
THEWI_RS05895	COG3804	dihydrodipicolinate reductase
THEWI_RS05905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THEWI_RS05915	COG5012	cobalamin binding
THEWI_RS05935	COG1959	2 iron, 2 sulfur cluster binding
THEWI_RS05945	COG0628	permease
THEWI_RS05955	COG4472	Bacterial protein of unknown function (DUF965)
THEWI_RS05960	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THEWI_RS05965	COG3906	Belongs to the UPF0473 family
THEWI_RS05970	COG0735	belongs to the Fur family
THEWI_RS05975	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
THEWI_RS05980	COG3679	Belongs to the UPF0342 family
THEWI_RS05985	COG4708	membrane
THEWI_RS05990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THEWI_RS05995	COG4122	O-methyltransferase activity
THEWI_RS06000	COG0826	peptidase U32
THEWI_RS06005	COG0768	penicillin binding
THEWI_RS06015	COG0546	phosphoglycolate phosphatase activity
THEWI_RS06020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THEWI_RS06025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THEWI_RS06040	COG4968	Prepilin-type N-terminal cleavage methylation domain
THEWI_RS06045	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THEWI_RS06090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THEWI_RS06105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THEWI_RS06115	COG0006	proline dipeptidase activity
THEWI_RS06130	COG3854	ATPases associated with a variety of cellular activities
THEWI_RS06170	COG1302	Protein conserved in bacteria
THEWI_RS06180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THEWI_RS06185	COG1570	exodeoxyribonuclease VII activity
THEWI_RS06190	COG1722	exodeoxyribonuclease VII activity
THEWI_RS06195	COG0142	geranyltranstransferase activity
THEWI_RS06205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THEWI_RS06210	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
THEWI_RS06220	COG1438	arginine binding
THEWI_RS06225	COG0497	DNA recombination
THEWI_RS06230	COG0750	zinc metalloprotease
THEWI_RS06270	COG1379	DNA repair
THEWI_RS06275	COG1300	Membrane
THEWI_RS06285	COG1686	Belongs to the peptidase S11 family
THEWI_RS06290	COG1366	Belongs to the anti-sigma-factor antagonist family
THEWI_RS06305	COG3360	Dodecin
THEWI_RS06325	COG0517	IMP dehydrogenase activity
THEWI_RS06325	COG0617	tRNA 3'-terminal CCA addition
THEWI_RS06325	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEWI_RS06330	COG1994	Peptidase M50
THEWI_RS06340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THEWI_RS06365	COG3874	Sporulation protein YtfJ
THEWI_RS06375	COG1686	Belongs to the peptidase S11 family
THEWI_RS06390	COG0445	tRNA wobble uridine modification
THEWI_RS06395	COG1187	pseudouridine synthase activity
THEWI_RS06410	COG0010	Belongs to the arginase family
THEWI_RS06420	COG1705	Flagellar rod assembly protein muramidase FlgJ
THEWI_RS06420	COG1388	LysM domain
THEWI_RS06440	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THEWI_RS06440	COG0674	pyruvate-flavodoxin oxidoreductase activity
THEWI_RS06445	COG1013	pyruvate-flavodoxin oxidoreductase activity
THEWI_RS06470	COG0406	alpha-ribazole phosphatase activity
THEWI_RS06475	COG2081	HI0933 family
THEWI_RS06490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THEWI_RS06505	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THEWI_RS06505	COG0539	negative regulation of cytoplasmic translation
THEWI_RS06520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THEWI_RS06525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEWI_RS06530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THEWI_RS06550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THEWI_RS06560	COG4974	Belongs to the 'phage' integrase family
THEWI_RS06565	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
THEWI_RS06570	COG0464	growth
THEWI_RS06585	COG0613	PHP domain protein
THEWI_RS06590	COG2359	stage V sporulation protein S
THEWI_RS06595	COG1692	metallophosphoesterase
THEWI_RS06615	COG2137	regulation of response to DNA damage stimulus
THEWI_RS06620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THEWI_RS06625	COG1058	Belongs to the CinA family
THEWI_RS06625	COG1546	Belongs to the CinA family
THEWI_RS06630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THEWI_RS06635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEWI_RS06650	COG0740	serine-type endopeptidase activity
THEWI_RS06655	COG0527	aspartate kinase activity
THEWI_RS06670	COG0612	Peptidase, M16
THEWI_RS06680	COG1185	polyribonucleotide nucleotidyltransferase activity
THEWI_RS06695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THEWI_RS06700	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEWI_RS06705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THEWI_RS06720	COG2740	Nucleic-acid-binding protein implicated in transcription termination
THEWI_RS06725	COG0195	Participates in both transcription termination and antitermination
THEWI_RS06730	COG0779	Required for maturation of 30S ribosomal subunits
THEWI_RS06735	COG2176	DNA-directed DNA polymerase activity
THEWI_RS06745	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THEWI_RS06750	COG0750	zinc metalloprotease
THEWI_RS06755	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THEWI_RS06760	COG4589	Belongs to the CDS family
THEWI_RS06765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THEWI_RS06780	COG0528	UMP kinase activity
THEWI_RS06805	COG1191	sigma factor activity
THEWI_RS06810	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THEWI_RS06815	COG1776	CheC inhibitor of MCP methylation
THEWI_RS06820	COG0835	chemotaxis
THEWI_RS06825	COG0643	Histidine kinase
THEWI_RS06825	COG2198	Histidine kinase
THEWI_RS06830	COG2201	protein-glutamate methylesterase activity
THEWI_RS06840	COG0455	bacterial-type flagellum organization
THEWI_RS06845	COG1419	protein localization to endoplasmic reticulum
THEWI_RS06850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THEWI_RS06855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THEWI_RS06860	COG1684	flagellar biosynthetic protein fliR
THEWI_RS06865	COG1987	bacterial-type flagellum assembly
THEWI_RS06870	COG1338	Plays a role in the flagellum-specific transport system
THEWI_RS06880	COG2201	protein-glutamate methylesterase activity
THEWI_RS06885	COG1776	CheC inhibitor of MCP methylation
THEWI_RS06885	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THEWI_RS06890	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THEWI_RS06900	COG1582	Flagellar protein (FlbD)
THEWI_RS06915	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THEWI_RS06935	COG1157	protein secretion by the type III secretion system
THEWI_RS06945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THEWI_RS06955	COG1677	Flagellar hook-basal body complex protein FliE
THEWI_RS06965	COG1815	bacterial-type flagellum-dependent cell motility
THEWI_RS06970	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
THEWI_RS06980	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THEWI_RS06985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THEWI_RS06990	COG0758	DNA mediated transformation
THEWI_RS06990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THEWI_RS06995	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THEWI_RS07000	COG0792	nuclease activity
THEWI_RS07005	COG0180	Tryptophanyl-tRNA synthetase
THEWI_RS07010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THEWI_RS07015	COG0606	chelatase, subunit chli
THEWI_RS07030	COG0336	Belongs to the RNA methyltransferase TrmD family
THEWI_RS07040	COG1837	Belongs to the UPF0109 family
THEWI_RS07045	COG0228	four-way junction DNA binding
THEWI_RS07050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THEWI_RS07055	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
THEWI_RS07060	COG0552	protein localization to endoplasmic reticulum
THEWI_RS07075	COG2359	stage V sporulation protein S
THEWI_RS07085	COG0571	ribonuclease III activity
THEWI_RS07090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THEWI_RS07100	COG1028	Short-chain dehydrogenase reductase Sdr
THEWI_RS07105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THEWI_RS07110	COG2070	2-Nitropropane dioxygenase
THEWI_RS07115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THEWI_RS07120	COG0416	fatty acid biosynthetic process
THEWI_RS07130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THEWI_RS07135	COG1399	metal-binding, possibly nucleic acid-binding protein
THEWI_RS07140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THEWI_RS07145	COG0280	phosphate acetyltransferase
THEWI_RS07155	COG3314	Sporulation integral membrane protein YlbJ
THEWI_RS07170	COG0742	ribosomal rna small subunit methyltransferase
THEWI_RS07185	COG1307	EDD domain protein, DegV family
THEWI_RS07190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THEWI_RS07195	COG1461	Dihydroxyacetone kinase
THEWI_RS07200	COG1302	Protein conserved in bacteria
THEWI_RS07225	COG1162	GTPase activity
THEWI_RS07230	COG0515	serine threonine protein kinase
THEWI_RS07230	COG2815	serine threonine protein kinase
THEWI_RS07235	COG0631	protein serine/threonine phosphatase activity
THEWI_RS07245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THEWI_RS07245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THEWI_RS07250	COG2738	Putative neutral zinc metallopeptidase
THEWI_RS07260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THEWI_RS07265	COG0242	peptide deformylase activity
THEWI_RS07270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THEWI_RS07275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THEWI_RS07285	COG0194	GDP metabolic process
THEWI_RS07295	COG1561	YicC-like family, N-terminal region
THEWI_RS07300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THEWI_RS07305	COG2814	Major facilitator Superfamily
THEWI_RS07330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
THEWI_RS07335	COG2011	ABC-type metal ion transport system permease component
THEWI_RS07345	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THEWI_RS07365	COG0037	tRNA processing
THEWI_RS07390	COG0543	2 iron, 2 sulfur cluster binding
THEWI_RS07405	COG0540	Belongs to the ATCase OTCase family
THEWI_RS07415	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THEWI_RS07420	COG0564	pseudouridine synthase activity
THEWI_RS07425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THEWI_RS07480	COG1970	mechanosensitive ion channel activity
THEWI_RS07490	COG0778	Nitroreductase
THEWI_RS07495	COG1595	DNA-templated transcription, initiation
THEWI_RS07515	COG1983	PspC domain protein
THEWI_RS07535	COG0626	cystathionine gamma-synthase activity
THEWI_RS07540	COG3344	reverse transcriptase
THEWI_RS07565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THEWI_RS07570	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THEWI_RS07590	COG0134	indole-3-glycerol-phosphate synthase activity
THEWI_RS07600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THEWI_RS07600	COG0512	Glutamine amidotransferase of anthranilate synthase
THEWI_RS07620	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THEWI_RS07650	COG3599	regulation of cell shape
THEWI_RS07655	COG2302	S4 RNA-binding domain
THEWI_RS07670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THEWI_RS07690	COG4948	Mandelate Racemase Muconate Lactonizing
THEWI_RS07705	COG2610	gluconate transmembrane transporter activity
THEWI_RS07710	COG1929	Belongs to the glycerate kinase type-1 family
THEWI_RS07730	COG2151	metal-sulfur cluster biosynthetic enzyme
THEWI_RS07730	COG0489	protein tyrosine kinase activity
THEWI_RS07755	COG0640	Transcriptional regulator
THEWI_RS07770	COG2814	Major facilitator Superfamily
THEWI_RS07780	COG1131	(ABC) transporter
THEWI_RS07790	COG0653	protein targeting
THEWI_RS07795	COG0531	amino acid
THEWI_RS07810	COG0204	Acyl-transferase
THEWI_RS07815	COG0745	RESPONSE REGULATOR receiver
THEWI_RS07830	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
THEWI_RS07840	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THEWI_RS07845	COG1160	GTP binding
THEWI_RS07885	COG0704	Plays a role in the regulation of phosphate uptake
THEWI_RS07890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THEWI_RS07895	COG0581	inorganic phosphate transmembrane transporter activity
THEWI_RS07900	COG0573	inorganic phosphate transmembrane transporter activity
THEWI_RS07905	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THEWI_RS07915	COG0745	RESPONSE REGULATOR receiver
THEWI_RS07920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THEWI_RS07930	COG1873	PFAM PRC-barrel domain
THEWI_RS07935	COG1191	sigma factor activity
THEWI_RS07940	COG1191	sigma factor activity
THEWI_RS07950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THEWI_RS07955	COG0849	cell division
THEWI_RS07960	COG3856	small basic protein
THEWI_RS07975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THEWI_RS07985	COG0772	Belongs to the SEDS family
THEWI_RS07990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THEWI_RS08000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THEWI_RS08005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THEWI_RS08010	COG0768	penicillin binding
THEWI_RS08030	COG0612	Peptidase, M16
THEWI_RS08035	COG0612	Peptidase, M16
THEWI_RS08065	COG0301	tRNA thio-modification
THEWI_RS08080	COG3344	reverse transcriptase
THEWI_RS08095	COG0508	dehydrogenase complex catalyzes the overall conversion of
THEWI_RS08100	COG3199	ATP-NAD kinase
THEWI_RS08105	COG0022	dehydrogenase e1 component
THEWI_RS08110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
THEWI_RS08115	COG0459	protein refolding
THEWI_RS08125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THEWI_RS08130	COG0321	lipoyl(octanoyl) transferase activity
THEWI_RS08150	COG2340	Cysteine-rich secretory protein family
THEWI_RS08155	COG1362	aminopeptidase activity
THEWI_RS08160	COG2197	response regulator
THEWI_RS08180	COG1683	Conserved Protein
THEWI_RS08185	COG1193	negative regulation of DNA recombination
THEWI_RS08190	COG0826	peptidase U32
THEWI_RS08200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEWI_RS08200	COG0072	phenylalanine-tRNA ligase activity
THEWI_RS08205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THEWI_RS08220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THEWI_RS08225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THEWI_RS08230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THEWI_RS08240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THEWI_RS08250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THEWI_RS08255	COG4399	Belongs to the UPF0754 family
THEWI_RS08270	COG0745	RESPONSE REGULATOR receiver
THEWI_RS08275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THEWI_RS08310	COG1278	Cold shock
THEWI_RS08315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THEWI_RS08330	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
THEWI_RS08335	COG1956	GAF domain-containing protein
THEWI_RS08360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THEWI_RS08380	COG1482	cell wall glycoprotein biosynthetic process
THEWI_RS08390	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THEWI_RS08395	COG2384	SAM-dependent methyltransferase
THEWI_RS08410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THEWI_RS08415	COG0358	DNA primase activity
THEWI_RS08420	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THEWI_RS08425	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THEWI_RS08430	COG0148	phosphopyruvate hydratase activity
THEWI_RS08435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THEWI_RS08440	COG0149	triose-phosphate isomerase activity
THEWI_RS08445	COG0126	phosphoglycerate kinase activity
THEWI_RS08455	COG2390	Transcriptional regulator
THEWI_RS08460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
THEWI_RS08465	COG1254	Belongs to the acylphosphatase family
THEWI_RS08470	COG0561	phosphatase activity
THEWI_RS08485	COG2720	vancomycin resistance protein
THEWI_RS08490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THEWI_RS08495	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THEWI_RS08500	COG1067	ATP-dependent peptidase activity
THEWI_RS08525	COG0840	transmembrane signaling receptor activity
THEWI_RS08530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THEWI_RS08560	COG3464	Transposase
THEWI_RS08600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THEWI_RS08615	COG2721	sulfolactate sulfo-lyase activity
THEWI_RS08630	COG1070	Carbohydrate kinase
THEWI_RS08645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THEWI_RS08655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THEWI_RS08660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THEWI_RS08670	COG0613	PHP domain protein
THEWI_RS08675	COG0546	phosphoglycolate phosphatase activity
THEWI_RS08680	COG0698	ribose 5-phosphate isomerase
THEWI_RS08685	COG3958	Transketolase
THEWI_RS08690	COG3959	Transketolase, thiamine diphosphate binding domain
THEWI_RS08695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THEWI_RS08710	COG0564	pseudouridine synthase activity
THEWI_RS08725	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
THEWI_RS08740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THEWI_RS08745	COG0463	Glycosyl transferase, family 2
THEWI_RS08775	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
THEWI_RS08785	COG3546	catalase activity
THEWI_RS08790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
THEWI_RS08795	COG0646	methionine synthase
THEWI_RS08795	COG1410	methionine synthase
THEWI_RS08800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THEWI_RS08800	COG0646	methionine synthase
THEWI_RS08805	COG0058	SHG alpha-glucan phosphorylase activity
THEWI_RS08810	COG0166	Belongs to the GPI family
THEWI_RS08820	COG0778	Nitroreductase
THEWI_RS08825	COG2195	Cleaves the N-terminal amino acid of tripeptides
THEWI_RS08840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEWI_RS08850	COG1174	glycine betaine transport
THEWI_RS08855	COG0517	IMP dehydrogenase activity
THEWI_RS08855	COG1125	glycine betaine transport
THEWI_RS08860	COG0471	metal ion transport
THEWI_RS08860	COG3273	potassium ion transport
THEWI_RS08865	COG0534	Mate efflux family protein
THEWI_RS08885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THEWI_RS08920	COG4109	DRTGG domain
THEWI_RS08925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEWI_RS08930	COG1481	regulation of sporulation
THEWI_RS08940	COG0366	Alpha amylase catalytic
THEWI_RS08945	COG1426	Protein conserved in bacteria
THEWI_RS08960	COG3833	ABC-type maltose transport systems, permease component
THEWI_RS08965	COG1175	transmembrane transport
THEWI_RS08970	COG2182	Extracellular solute-binding protein
THEWI_RS08995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THEWI_RS09000	COG1752	Esterase of the alpha-beta hydrolase superfamily
THEWI_RS09005	COG1309	transcriptional regulator
THEWI_RS09010	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THEWI_RS09035	COG2217	Heavy metal translocating P-type atpase
THEWI_RS09040	COG0482	sulfurtransferase activity
THEWI_RS09050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THEWI_RS09055	COG2608	mercury ion transmembrane transporter activity
THEWI_RS09060	COG0586	Pfam SNARE associated Golgi protein
THEWI_RS09065	COG1342	Belongs to the UPF0251 family
THEWI_RS09070	COG5002	protein histidine kinase activity
THEWI_RS09070	COG5001	Diguanylate cyclase
THEWI_RS09070	COG3447	MASE1 domain protein
THEWI_RS09105	COG1918	ferrous iron import across plasma membrane
THEWI_RS09105	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THEWI_RS09135	COG1120	ATPase activity
THEWI_RS09140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THEWI_RS09155	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEWI_RS09160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THEWI_RS09175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEWI_RS09185	COG0489	protein tyrosine kinase activity
THEWI_RS09190	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THEWI_RS09210	COG2226	methyltransferase
THEWI_RS09230	COG1609	Transcriptional regulator
THEWI_RS09235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THEWI_RS09255	COG2182	Extracellular solute-binding protein
THEWI_RS09310	COG0483	inositol monophosphate 1-phosphatase activity
THEWI_RS09335	COG1070	Carbohydrate kinase
THEWI_RS09340	COG0434	BtpA family
THEWI_RS09345	COG1349	DNA-binding transcription factor activity
THEWI_RS09355	COG0653	protein targeting
THEWI_RS09380	COG0842	Transport permease protein
THEWI_RS09380	COG1129	ABC transporter
THEWI_RS09385	COG1131	(ABC) transporter
THEWI_RS09405	COG3250	beta-galactosidase activity
THEWI_RS09435	COG1940	carbohydrate kinase activity
THEWI_RS09440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THEWI_RS09445	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THEWI_RS09450	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
THEWI_RS09460	COG0800	Aldolase
THEWI_RS09465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THEWI_RS09475	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THEWI_RS09480	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEWI_RS09480	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THEWI_RS09485	COG3716	PTS system mannose fructose sorbose family IID component
THEWI_RS09495	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEWI_RS09495	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THEWI_RS09505	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEWI_RS09505	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEWI_RS09510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THEWI_RS09520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THEWI_RS09525	COG1349	DNA-binding transcription factor activity
THEWI_RS09535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THEWI_RS09560	COG0673	inositol 2-dehydrogenase activity
THEWI_RS09565	COG0673	inositol 2-dehydrogenase activity
THEWI_RS09600	COG3885	ferrous iron binding
THEWI_RS09600	COG2078	PFAM AMMECR1 domain protein
THEWI_RS09610	COG0318	PFAM AMP-dependent synthetase and ligase
THEWI_RS09640	COG0768	penicillin binding
THEWI_RS09660	COG0556	nucleotide-excision repair
THEWI_RS09665	COG2045	Belongs to the ComB family
THEWI_RS09670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEWI_RS09675	COG3409	Peptidoglycan-binding domain 1 protein
THEWI_RS09675	COG0793	Belongs to the peptidase S41A family
THEWI_RS09680	COG0739	heme binding
THEWI_RS09685	COG2177	Part of the ABC transporter FtsEX involved in
THEWI_RS09690	COG2884	Cell division ATP-binding protein ftsE
THEWI_RS09695	COG3835	regulator
THEWI_RS09700	COG3842	ATPase activity
THEWI_RS09710	COG0019	diaminopimelate decarboxylase activity
THEWI_RS09740	COG2161	toxin-antitoxin pair type II binding
THEWI_RS09770	COG3464	Transposase
THEWI_RS09840	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
THEWI_RS09840	COG0493	'glutamate synthase
THEWI_RS09895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THEWI_RS09905	COG0849	cell division
THEWI_RS09945	COG0443	Heat shock 70 kDa protein
THEWI_RS09950	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THEWI_RS09955	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
THEWI_RS09955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEWI_RS09955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEWI_RS09965	COG2376	Dihydroxyacetone kinase
THEWI_RS09980	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEWI_RS09995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THEWI_RS10000	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
THEWI_RS10025	COG2205	protein histidine kinase activity
THEWI_RS10030	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
THEWI_RS10035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
THEWI_RS10040	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
THEWI_RS10045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THEWI_RS10055	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THEWI_RS10060	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THEWI_RS10075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THEWI_RS10075	COG0140	phosphoribosyl-ATP diphosphatase activity
THEWI_RS10090	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THEWI_RS10095	COG0131	Imidazoleglycerol-phosphate dehydratase
THEWI_RS10100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THEWI_RS10105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THEWI_RS10145	COG1131	(ABC) transporter
THEWI_RS10150	COG3459	Glycosyltransferase 36 associated
THEWI_RS10155	COG0598	Magnesium transport protein CorA
THEWI_RS10165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
THEWI_RS10170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THEWI_RS10170	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
THEWI_RS10175	COG0673	inositol 2-dehydrogenase activity
THEWI_RS10180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THEWI_RS10185	COG2873	o-acetylhomoserine
THEWI_RS10190	COG0460	homoserine dehydrogenase
THEWI_RS10215	COG1773	rubredoxin
THEWI_RS10220	COG2205	protein histidine kinase activity
THEWI_RS10225	COG1757	Na H antiporter
THEWI_RS10230	COG0205	6-phosphofructokinase activity
THEWI_RS10240	COG3958	Transketolase
THEWI_RS10245	COG3959	Transketolase, thiamine diphosphate binding domain
THEWI_RS10250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THEWI_RS10280	COG2337	Toxic component of a toxin-antitoxin (TA) module
THEWI_RS10290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THEWI_RS10300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THEWI_RS10300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THEWI_RS10360	COG1131	(ABC) transporter
THEWI_RS10375	COG0450	alkyl hydroperoxide reductase
THEWI_RS10410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THEWI_RS10415	COG1172	Belongs to the binding-protein-dependent transport system permease family
THEWI_RS10425	COG1879	ABC-type sugar transport system periplasmic component
THEWI_RS10430	COG1609	Transcriptional regulator
THEWI_RS10490	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THEWI_RS10495	COG5012	cobalamin binding
THEWI_RS10520	COG3716	PTS system mannose fructose sorbose family IID component
THEWI_RS10525	COG3715	PTS system
THEWI_RS10530	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THEWI_RS10535	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEWI_RS10535	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEWI_RS10570	COG3716	PTS system mannose fructose sorbose family IID component
THEWI_RS10575	COG3715	PTS system
THEWI_RS10580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THEWI_RS10590	COG2188	Transcriptional regulator
THEWI_RS10605	COG0658	competence protein
THEWI_RS10605	COG2333	competence protein COMEC
THEWI_RS10630	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
THEWI_RS10635	COG1793	dna ligase
THEWI_RS10640	COG0432	Pfam Uncharacterised protein family UPF0047
THEWI_RS10695	COG1396	sequence-specific DNA binding
THEWI_RS10700	COG4974	Belongs to the 'phage' integrase family
THEWI_RS10710	COG0358	DNA primase activity
THEWI_RS10750	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
THEWI_RS10760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THEWI_RS10800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THEWI_RS10810	COG0318	PFAM AMP-dependent synthetase and ligase
THEWI_RS10810	COG0204	Acyl-transferase
THEWI_RS10825	COG0280	phosphate acetyltransferase
THEWI_RS10855	COG3426	butyrate kinase activity
THEWI_RS10865	COG0280	phosphate acetyltransferase
THEWI_RS10870	COG3426	butyrate kinase activity
THEWI_RS10880	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
THEWI_RS10920	COG0714	Associated with various cellular activities
THEWI_RS10925	COG0546	phosphoglycolate phosphatase activity
THEWI_RS10935	COG1705	Flagellar rod assembly protein muramidase FlgJ
THEWI_RS10935	COG1388	LysM domain
THEWI_RS10975	COG0708	Exodeoxyribonuclease III
THEWI_RS10980	COG2033	superoxide reductase activity
THEWI_RS10985	COG2198	Histidine kinase
THEWI_RS10985	COG0643	Histidine kinase
THEWI_RS10990	COG2198	Histidine kinase
THEWI_RS10990	COG0643	Histidine kinase
THEWI_RS11000	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THEWI_RS11010	COG2201	protein-glutamate methylesterase activity
THEWI_RS11015	COG0835	chemotaxis
THEWI_RS11030	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
THEWI_RS11030	COG2508	Transcriptional regulator
THEWI_RS11115	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THEWI_RS11120	COG1122	ATPase activity
THEWI_RS11125	COG1122	ATPase activity
THEWI_RS11145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THEWI_RS11160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THEWI_RS11180	COG0201	protein transport
THEWI_RS11200	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THEWI_RS11245	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THEWI_RS11275	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THEWI_RS11285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THEWI_RS11295	COG0049	tRNA binding
THEWI_RS11300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THEWI_RS11305	COG1358	cellular component organization or biogenesis
THEWI_RS11310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THEWI_RS11315	COG0085	RNA polymerase activity
THEWI_RS11320	COG0222	ribosome binding
THEWI_RS11330	COG0081	regulation of translation
THEWI_RS11340	COG0250	Participates in transcription elongation, termination and antitermination
THEWI_RS11345	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THEWI_RS11350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THEWI_RS11360	COG1595	DNA-templated transcription, initiation
THEWI_RS11365	COG3688	RNA-binding protein containing a PIN domain
THEWI_RS11370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THEWI_RS11385	COG1045	serine acetyltransferase
THEWI_RS11400	COG0442	prolyl-tRNA aminoacylation
THEWI_RS11405	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THEWI_RS11415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THEWI_RS11420	COG4956	integral membrane protein (PIN domain superfamily)
THEWI_RS11430	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THEWI_RS11435	COG1914	H( )-stimulated, divalent metal cation uptake system
THEWI_RS11445	COG0542	response to heat
THEWI_RS11450	COG3869	Catalyzes the specific phosphorylation of arginine residues in
THEWI_RS11455	COG3880	PFAM UvrB UvrC protein
THEWI_RS11470	COG0281	malic enzyme
THEWI_RS11475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THEWI_RS11480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEWI_RS11485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEWI_RS11490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEWI_RS11490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEWI_RS11490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEWI_RS11495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEWI_RS11495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEWI_RS11495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEWI_RS11500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEWI_RS11500	COG3711	transcriptional antiterminator
THEWI_RS11530	COG4946	Tricorn protease homolog
THEWI_RS11530	COG1506	peptidase
THEWI_RS11530	COG0823	Involved in the tonB-independent uptake of proteins
THEWI_RS11540	COG0720	synthase
THEWI_RS11545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THEWI_RS11550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THEWI_RS11570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THEWI_RS11570	COG5322	oxidoreductase activity
THEWI_RS11595	COG0697	spore germination
THEWI_RS11600	COG0531	amino acid
THEWI_RS11610	COG4684	Psort location CytoplasmicMembrane, score
THEWI_RS11615	COG4770	biotin carboxylase activity
THEWI_RS11625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THEWI_RS11630	COG0346	lactoylglutathione lyase activity
THEWI_RS11640	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEWI_RS11640	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEWI_RS11645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEWI_RS11645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEWI_RS11660	COG3852	Histidine kinase
THEWI_RS11670	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THEWI_RS11675	COG0037	tRNA processing
THEWI_RS11685	COG2208	phosphoserine phosphatase activity
THEWI_RS11695	COG2226	methyltransferase
THEWI_RS11700	COG3464	Transposase
THEWI_RS11705	COG0697	spore germination
THEWI_RS11710	COG1595	DNA-templated transcription, initiation
THEWI_RS11720	COG1131	(ABC) transporter
THEWI_RS11740	COG1063	alcohol dehydrogenase
THEWI_RS11745	COG0156	8-amino-7-oxononanoate synthase activity
THEWI_RS11770	COG2151	metal-sulfur cluster biosynthetic enzyme
THEWI_RS11785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
THEWI_RS11790	COG0022	dehydrogenase e1 component
THEWI_RS11820	COG5001	Diguanylate cyclase
THEWI_RS11820	COG3300	MHYT domain
THEWI_RS11890	COG1598	PFAM Uncharacterised protein family UPF0150
THEWI_RS11915	COG0745	RESPONSE REGULATOR receiver
THEWI_RS11925	COG2199	diguanylate cyclase activity
THEWI_RS11925	COG2203	Gaf domain
THEWI_RS11940	COG1366	Belongs to the anti-sigma-factor antagonist family
THEWI_RS11945	COG1366	Belongs to the anti-sigma-factor antagonist family
THEWI_RS11950	COG3328	transposase activity
THEWI_RS11955	COG3464	Transposase
THEWI_RS11960	COG3464	Transposase
THEWI_RS12040	COG4962	Type ii secretion system protein e
THEWI_RS12060	COG0739	heme binding
THEWI_RS12155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THEWI_RS12190	COG1396	sequence-specific DNA binding
THEWI_RS12215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THEWI_RS12215	COG0248	Ppx GppA phosphatase
THEWI_RS12220	COG1098	S1 RNA binding domain
THEWI_RS12255	COG2385	sporulation resulting in formation of a cellular spore
THEWI_RS12260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THEWI_RS12265	COG0776	regulation of translation
THEWI_RS12270	COG3956	TIGRFAM MazG family protein
THEWI_RS12280	COG2814	Major facilitator Superfamily
THEWI_RS12285	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THEWI_RS12290	COG3850	Histidine kinase
THEWI_RS12290	COG5002	protein histidine kinase activity
THEWI_RS12295	COG0745	RESPONSE REGULATOR receiver
THEWI_RS12300	COG2033	superoxide reductase activity
THEWI_RS12310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THEWI_RS12330	COG2217	Heavy metal translocating P-type atpase
THEWI_RS12345	COG0037	tRNA processing
THEWI_RS12350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THEWI_RS12385	COG0142	geranyltranstransferase activity
THEWI_RS12415	COG0454	-acetyltransferase
THEWI_RS12440	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THEWI_RS12455	COG1595	DNA-templated transcription, initiation
THEWI_RS12475	COG1725	Transcriptional regulator
THEWI_RS12480	COG1164	Oligoendopeptidase f
THEWI_RS12500	COG0505	Belongs to the CarA family
THEWI_RS12505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THEWI_RS12510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THEWI_RS12515	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THEWI_RS12520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THEWI_RS12535	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THEWI_RS12555	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
THEWI_RS12555	COG0493	'glutamate synthase
THEWI_RS12570	COG1796	DNA polymerase
THEWI_RS12570	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THEWI_RS12595	COG0671	phosphoesterase, PA-phosphatase related
THEWI_RS12605	COG1132	(ABC) transporter
THEWI_RS12620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THEWI_RS12620	COG1796	DNA polymerase
THEWI_RS12635	COG1454	alcohol dehydrogenase
THEWI_RS12635	COG1012	belongs to the aldehyde dehydrogenase family
THEWI_RS12645	COG0667	Aldo Keto reductase
THEWI_RS12660	COG0747	negative chemotaxis
THEWI_RS12665	COG0601	transmembrane transport
THEWI_RS12670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THEWI_RS12675	COG0444	Belongs to the ABC transporter superfamily
THEWI_RS12680	COG4608	Belongs to the ABC transporter superfamily
THEWI_RS12705	COG1131	(ABC) transporter
THEWI_RS12715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THEWI_RS12720	COG0018	arginyl-trna synthetase
THEWI_RS12760	COG0531	amino acid
THEWI_RS12765	COG0697	spore germination
THEWI_RS12780	COG1802	Transcriptional regulator
THEWI_RS12785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THEWI_RS12790	COG1388	LysM domain
THEWI_RS12795	COG4466	Protein conserved in bacteria
THEWI_RS12805	COG2002	toxin-antitoxin pair type II binding
THEWI_RS12810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THEWI_RS12815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THEWI_RS12830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEWI_RS12835	COG3850	Histidine kinase
THEWI_RS12835	COG5002	protein histidine kinase activity
THEWI_RS12845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THEWI_RS12850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THEWI_RS12855	COG2088	sporulation resulting in formation of a cellular spore
THEWI_RS12860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THEWI_RS12865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THEWI_RS12870	COG1609	Transcriptional regulator
THEWI_RS12880	COG0071	Belongs to the small heat shock protein (HSP20) family
THEWI_RS12890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEWI_RS12890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEWI_RS12890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEWI_RS12900	COG1349	DNA-binding transcription factor activity
THEWI_RS12905	COG2373	Large extracellular alpha-helical protein
THEWI_RS12920	COG3266	domain, Protein
THEWI_RS12920	COG2911	Protein conserved in bacteria
THEWI_RS12920	COG1361	Conserved repeat domain
THEWI_RS12925	COG4991	sh3 domain protein
THEWI_RS12925	COG3064	Membrane
THEWI_RS12925	COG0515	serine threonine protein kinase
THEWI_RS12940	COG0504	CTP synthase activity
THEWI_RS12945	COG2886	Uncharacterised protein family (UPF0175)
THEWI_RS12955	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THEWI_RS12960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THEWI_RS12965	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THEWI_RS12980	COG0083	homoserine kinase activity
THEWI_RS12985	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THEWI_RS12990	COG0460	homoserine dehydrogenase
THEWI_RS13005	COG0531	amino acid
THEWI_RS13010	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
THEWI_RS13020	COG3464	Transposase
THEWI_RS13040	COG3464	Transposase
THEWI_RS13045	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THEWI_RS13050	COG1518	maintenance of DNA repeat elements
THEWI_RS13060	COG3340	Belongs to the peptidase S51 family
THEWI_RS13110	COG0822	iron-sulfur transferase activity
THEWI_RS13115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THEWI_RS13125	COG0719	Fe-S assembly protein
THEWI_RS13130	COG0396	ATPase activity
THEWI_RS13135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THEWI_RS13165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THEWI_RS13175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THEWI_RS13180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEWI_RS13185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THEWI_RS13205	COG5002	protein histidine kinase activity
THEWI_RS13230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THEWI_RS13235	COG0308	aminopeptidase N
THEWI_RS13250	COG0658	competence protein
THEWI_RS13250	COG2333	competence protein COMEC
THEWI_RS13305	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
THEWI_RS13310	COG0840	transmembrane signaling receptor activity
THEWI_RS13320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THEWI_RS13325	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEWI_RS13335	COG3344	reverse transcriptase
THEWI_RS13340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THEWI_RS13345	COG1164	Oligoendopeptidase f
THEWI_RS13350	COG2226	methyltransferase
THEWI_RS13355	COG4555	ABC transporter
THEWI_RS13375	COG1132	(ABC) transporter
THEWI_RS13400	COG1132	(ABC) transporter
THEWI_RS13420	COG1132	(ABC) transporter
THEWI_RS13425	COG1132	(ABC) transporter
THEWI_RS13440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THEWI_RS13445	COG0305	Participates in initiation and elongation during chromosome replication
THEWI_RS13475	COG0629	single-stranded DNA binding
THEWI_RS13485	COG4481	Protein conserved in bacteria
THEWI_RS13490	COG0668	transmembrane transport
THEWI_RS13505	COG4242	Belongs to the peptidase S51 family
THEWI_RS13510	COG1597	lipid kinase activity
THEWI_RS13520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THEWI_RS13530	COG1475	DNA binding
THEWI_RS13535	COG1192	Involved in chromosome partitioning
THEWI_RS13560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THEWI_RS13565	COG1847	R3H domain protein
THEWI_RS13570	COG0706	membrane insertase activity
THEWI_RS13615	COG1131	(ABC) transporter
THEWI_RS13620	COG1595	DNA-templated transcription, initiation
THEWI_RS13660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
THEWI_RS13695	COG0641	radical SAM