locus-tag	class	description
GSH73_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GSH73_RS00010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GSH73_RS00015	COG0594	ribonuclease P activity
GSH73_RS00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GSH73_RS00025	COG0706	membrane insertase activity
GSH73_RS00030	COG1847	R3H domain protein
GSH73_RS00035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GSH73_RS00040	COG0445	tRNA wobble uridine modification
GSH73_RS00045	COG0357	Ribosomal RNA small subunit methyltransferase G
GSH73_RS00050	COG1051	belongs to the nudix hydrolase family
GSH73_RS00050	COG1056	cytidyltransferase-related domain
GSH73_RS00060	COG1192	Involved in chromosome partitioning
GSH73_RS00065	COG1475	DNA binding
GSH73_RS00070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GSH73_RS00075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GSH73_RS00110	COG0668	transmembrane transport
GSH73_RS00115	COG4481	Protein conserved in bacteria
GSH73_RS00120	COG0360	Binds together with S18 to 16S ribosomal RNA
GSH73_RS00125	COG0629	single-stranded DNA binding
GSH73_RS00130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GSH73_RS00145	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GSH73_RS00150	COG0359	binds to the 23S rRNA
GSH73_RS00155	COG0305	Participates in initiation and elongation during chromosome replication
GSH73_RS00160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GSH73_RS00165	COG2239	Acts as a magnesium transporter
GSH73_RS00175	COG0745	RESPONSE REGULATOR receiver
GSH73_RS00180	COG3850	Histidine kinase
GSH73_RS00180	COG5002	protein histidine kinase activity
GSH73_RS00190	COG0840	transmembrane signaling receptor activity
GSH73_RS00195	COG3610	response to peptide
GSH73_RS00205	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GSH73_RS00210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GSH73_RS00240	COG2045	Belongs to the ComB family
GSH73_RS00265	COG0745	RESPONSE REGULATOR receiver
GSH73_RS00270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSH73_RS00275	COG1917	Cupin 2, conserved barrel domain protein
GSH73_RS00275	COG2207	Transcriptional regulator
GSH73_RS00280	COG3547	Transposase (IS116 IS110 IS902 family)
GSH73_RS00290	COG0673	inositol 2-dehydrogenase activity
GSH73_RS00300	COG1175	transmembrane transport
GSH73_RS00305	COG0395	ABC-type sugar transport system, permease component
GSH73_RS00310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GSH73_RS00320	COG0446	pyridine nucleotide-disulphide oxidoreductase
GSH73_RS00330	COG3547	Transposase (IS116 IS110 IS902 family)
GSH73_RS00335	COG0281	malic enzyme
GSH73_RS00355	COG3290	protein histidine kinase activity
GSH73_RS00425	COG2801	Transposase and inactivated derivatives
GSH73_RS00440	COG4974	Belongs to the 'phage' integrase family
GSH73_RS00495	COG3547	Transposase (IS116 IS110 IS902 family)
GSH73_RS00540	COG0745	RESPONSE REGULATOR receiver
GSH73_RS00545	COG5002	protein histidine kinase activity
GSH73_RS00565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GSH73_RS00570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSH73_RS00585	COG3706	GGDEF domain
GSH73_RS00640	COG1924	4 iron, 4 sulfur cluster binding
GSH73_RS00660	COG0667	Aldo Keto reductase
GSH73_RS00670	COG1454	alcohol dehydrogenase
GSH73_RS00670	COG1012	belongs to the aldehyde dehydrogenase family
GSH73_RS00765	COG0719	Fe-S assembly protein
GSH73_RS00770	COG0719	Fe-S assembly protein
GSH73_RS00775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GSH73_RS00780	COG0822	iron-sulfur transferase activity
GSH73_RS00820	COG1518	maintenance of DNA repeat elements
GSH73_RS00825	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GSH73_RS00835	COG1846	Transcriptional regulator
GSH73_RS00845	COG1132	(ABC) transporter
GSH73_RS00850	COG1013	pyruvate-flavodoxin oxidoreductase activity
GSH73_RS00855	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GSH73_RS00855	COG0674	pyruvate-flavodoxin oxidoreductase activity
GSH73_RS00860	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GSH73_RS00870	COG4492	Belongs to the UPF0735 family
GSH73_RS00875	COG0460	homoserine dehydrogenase
GSH73_RS00880	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GSH73_RS00885	COG0083	homoserine kinase activity
GSH73_RS00895	COG1929	Belongs to the glycerate kinase type-1 family
GSH73_RS00900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GSH73_RS00905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GSH73_RS00925	COG0504	CTP synthase activity
GSH73_RS00950	COG2373	Large extracellular alpha-helical protein
GSH73_RS00955	COG0745	RESPONSE REGULATOR receiver
GSH73_RS00960	COG2205	protein histidine kinase activity
GSH73_RS00960	COG2770	Histidine kinase
GSH73_RS00970	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GSH73_RS00975	COG0463	Glycosyl transferase, family 2
GSH73_RS01010	COG1349	DNA-binding transcription factor activity
GSH73_RS01015	COG1105	Belongs to the carbohydrate kinase PfkB family
GSH73_RS01020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSH73_RS01020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSH73_RS01020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSH73_RS01040	COG1609	Transcriptional regulator
GSH73_RS01050	COG1175	transmembrane transport
GSH73_RS01070	COG1132	(ABC) transporter
GSH73_RS01075	COG1132	(ABC) transporter
GSH73_RS01080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GSH73_RS01090	COG1136	(ABC) transporter
GSH73_RS01095	COG0577	efflux transmembrane transporter activity
GSH73_RS01095	COG1136	(ABC) transporter
GSH73_RS01105	COG2247	cell wall binding repeat
GSH73_RS01105	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSH73_RS01110	COG0745	RESPONSE REGULATOR receiver
GSH73_RS01125	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GSH73_RS01130	COG0254	rRNA binding
GSH73_RS01135	COG1435	thymidine kinase activity
GSH73_RS01140	COG3872	metal-dependent enzyme
GSH73_RS01145	COG2890	protein-(glutamine-N5) methyltransferase activity
GSH73_RS01160	COG0009	L-threonylcarbamoyladenylate synthase
GSH73_RS01165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GSH73_RS01170	COG0698	ribose 5-phosphate isomerase
GSH73_RS01175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GSH73_RS01185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GSH73_RS01190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GSH73_RS01200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GSH73_RS01220	COG0531	amino acid
GSH73_RS01225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSH73_RS01265	COG2385	sporulation resulting in formation of a cellular spore
GSH73_RS01275	COG1609	Transcriptional regulator
GSH73_RS01285	COG4786	Flagellar basal body rod
GSH73_RS01300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GSH73_RS01320	COG0840	transmembrane signaling receptor activity
GSH73_RS01325	COG0457	Tetratricopeptide repeat
GSH73_RS01325	COG0463	Glycosyl transferase, family 2
GSH73_RS01335	COG1979	alcohol dehydrogenase
GSH73_RS01340	COG4632	Exopolysaccharide biosynthesis protein
GSH73_RS01340	COG5434	Belongs to the glycosyl hydrolase 28 family
GSH73_RS01370	COG1070	Carbohydrate kinase
GSH73_RS01385	COG4214	carbohydrate transport
GSH73_RS01395	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GSH73_RS01400	COG1609	Transcriptional regulator
GSH73_RS01410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSH73_RS01415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSH73_RS01420	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GSH73_RS01435	COG3959	Transketolase, thiamine diphosphate binding domain
GSH73_RS01440	COG3958	Transketolase
GSH73_RS01475	COG2814	Major facilitator Superfamily
GSH73_RS01480	COG1122	ATPase activity
GSH73_RS01490	COG0310	cobalt ion transport
GSH73_RS01495	COG0310	cobalt ion transport
GSH73_RS01500	COG0864	Transcriptional regulator
GSH73_RS01510	COG1131	(ABC) transporter
GSH73_RS01535	COG2217	Heavy metal translocating P-type atpase
GSH73_RS01545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GSH73_RS01550	COG0534	Mate efflux family protein
GSH73_RS01590	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GSH73_RS01595	COG3875	lactate racemase activity
GSH73_RS01605	COG4716	Myosin-crossreactive antigen
GSH73_RS01615	COG1349	DNA-binding transcription factor activity
GSH73_RS01665	COG1063	alcohol dehydrogenase
GSH73_RS01675	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GSH73_RS01680	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GSH73_RS01685	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GSH73_RS01690	COG4869	propanediol catabolic process
GSH73_RS01695	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
GSH73_RS01700	COG4656	Part of a membrane complex involved in electron transport
GSH73_RS01710	COG4806	L-rhamnose isomerase
GSH73_RS01715	COG1070	Carbohydrate kinase
GSH73_RS01720	COG4753	response regulator
GSH73_RS01720	COG2207	Transcriptional regulator
GSH73_RS01745	COG1175	transmembrane transport
GSH73_RS01750	COG0395	ABC-type sugar transport system, permease component
GSH73_RS01755	COG1486	melibiose metabolic process
GSH73_RS01790	COG0297	glycogen (starch) synthase activity
GSH73_RS01795	COG0586	Pfam SNARE associated Golgi protein
GSH73_RS01810	COG0582	viral genome integration into host DNA
GSH73_RS01825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GSH73_RS01855	COG0039	L-malate dehydrogenase activity
GSH73_RS01870	COG0493	'glutamate synthase
GSH73_RS01880	COG1388	LysM domain
GSH73_RS01880	COG0791	NLP P60 protein
GSH73_RS01895	COG1904	glucuronate isomerase
GSH73_RS01900	COG1609	Transcriptional regulator
GSH73_RS01905	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GSH73_RS01915	COG1175	transmembrane transport
GSH73_RS01920	COG0395	ABC-type sugar transport system, permease component
GSH73_RS01930	COG0246	Mannitol dehydrogenase
GSH73_RS01935	COG2721	sulfolactate sulfo-lyase activity
GSH73_RS01945	COG0534	Mate efflux family protein
GSH73_RS01955	COG1349	DNA-binding transcription factor activity
GSH73_RS01965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GSH73_RS01970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GSH73_RS01975	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GSH73_RS01980	COG0246	Mannitol dehydrogenase
GSH73_RS01990	COG1653	transport
GSH73_RS02000	COG0395	ABC-type sugar transport system, permease component
GSH73_RS02005	COG3250	beta-galactosidase activity
GSH73_RS02020	COG1609	Transcriptional regulator
GSH73_RS02025	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GSH73_RS02030	COG1028	Short-chain dehydrogenase reductase Sdr
GSH73_RS02045	COG2972	Histidine kinase
GSH73_RS02050	COG2207	Transcriptional regulator
GSH73_RS02050	COG4753	response regulator
GSH73_RS02055	COG4213	ABC transporter substrate-binding protein
GSH73_RS02070	COG4214	carbohydrate transport
GSH73_RS02075	COG0436	Aminotransferase
GSH73_RS02085	COG0835	chemotaxis
GSH73_RS02090	COG0643	Histidine kinase
GSH73_RS02090	COG2198	Histidine kinase
GSH73_RS02095	COG0840	transmembrane signaling receptor activity
GSH73_RS02095	COG3290	protein histidine kinase activity
GSH73_RS02100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GSH73_RS02105	COG2201	protein-glutamate methylesterase activity
GSH73_RS02130	COG0495	leucyl-tRNA aminoacylation
GSH73_RS02150	COG1392	Phosphate transport regulator
GSH73_RS02155	COG0531	amino acid
GSH73_RS02160	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GSH73_RS02160	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GSH73_RS02170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GSH73_RS02185	COG1447	Phosphotransferase system cellobiose-specific component IIA
GSH73_RS02190	COG1486	melibiose metabolic process
GSH73_RS02195	COG1737	Transcriptional regulator
GSH73_RS02200	COG2190	(PTS) system
GSH73_RS02205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSH73_RS02205	COG1263	PTS System
GSH73_RS02220	COG0737	Belongs to the 5'-nucleotidase family
GSH73_RS02225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GSH73_RS02240	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GSH73_RS02290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GSH73_RS02295	COG1121	(ABC) transporter
GSH73_RS02300	COG0803	Belongs to the bacterial solute-binding protein 9 family
GSH73_RS02305	COG0735	belongs to the Fur family
GSH73_RS02310	COG0671	phosphoesterase, PA-phosphatase related
GSH73_RS02330	COG0436	Aminotransferase
GSH73_RS02335	COG1522	sequence-specific DNA binding
GSH73_RS02345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GSH73_RS02350	COG0116	Belongs to the methyltransferase superfamily
GSH73_RS02355	COG0531	amino acid
GSH73_RS02370	COG5464	transposase or invertase
GSH73_RS02385	COG5464	transposase or invertase
GSH73_RS02410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GSH73_RS02415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSH73_RS02420	COG1120	ATPase activity
GSH73_RS02425	COG1797	cobyrinic acid a,c-diamide synthase activity
GSH73_RS02450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GSH73_RS02455	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
GSH73_RS02460	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GSH73_RS02485	COG0484	heat shock protein binding
GSH73_RS02535	COG3404	Formiminotransferase-cyclodeaminase
GSH73_RS02540	COG1744	ABC transporter substrate-binding protein PnrA-like
GSH73_RS02560	COG2188	Transcriptional regulator
GSH73_RS02570	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GSH73_RS02580	COG0840	transmembrane signaling receptor activity
GSH73_RS02580	COG3290	protein histidine kinase activity
GSH73_RS02590	COG1263	PTS System
GSH73_RS02590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSH73_RS02595	COG2190	(PTS) system
GSH73_RS02600	COG3711	transcriptional antiterminator
GSH73_RS02605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GSH73_RS02610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GSH73_RS02620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GSH73_RS02630	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GSH73_RS02640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GSH73_RS02675	COG2323	membrane
GSH73_RS02680	COG0561	phosphatase activity
GSH73_RS02685	COG1609	Transcriptional regulator
GSH73_RS02695	COG0745	RESPONSE REGULATOR receiver
GSH73_RS02700	COG5002	protein histidine kinase activity
GSH73_RS02745	COG1592	Rubrerythrin
GSH73_RS02750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GSH73_RS02755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GSH73_RS02755	COG2199	diguanylate cyclase activity
GSH73_RS02765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GSH73_RS02770	COG1040	competence protein
GSH73_RS02790	COG1256	bacterial-type flagellum assembly
GSH73_RS02790	COG4786	Flagellar basal body rod
GSH73_RS02795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GSH73_RS02805	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GSH73_RS02810	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GSH73_RS02815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GSH73_RS02825	COG2604	Protein of unknown function DUF115
GSH73_RS02830	COG1086	Polysaccharide biosynthesis protein
GSH73_RS02835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GSH73_RS02840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GSH73_RS02845	COG2089	acid synthase
GSH73_RS02850	COG0110	maltose O-acetyltransferase activity
GSH73_RS02855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GSH73_RS02890	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GSH73_RS02895	COG1516	flagellar protein fliS
GSH73_RS02910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSH73_RS02915	COG0765	amino acid transport
GSH73_RS02920	COG1126	abc transporter atp-binding protein
GSH73_RS02945	COG1827	regulation of RNA biosynthetic process
GSH73_RS02970	COG2241	protein methyltransferase activity
GSH73_RS02975	COG2242	protein methyltransferase activity
GSH73_RS02985	COG2875	Belongs to the precorrin methyltransferase family
GSH73_RS03000	COG2099	Precorrin-6x reductase
GSH73_RS03005	COG0310	cobalt ion transport
GSH73_RS03015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GSH73_RS03020	COG1122	ATPase activity
GSH73_RS03025	COG0653	protein targeting
GSH73_RS03030	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GSH73_RS03035	COG2183	response to ionizing radiation
GSH73_RS03040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GSH73_RS03045	COG0398	Pfam SNARE associated Golgi protein
GSH73_RS03055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GSH73_RS03070	COG0802	atpase or kinase
GSH73_RS03075	COG1214	PFAM Peptidase M22, glycoprotease
GSH73_RS03080	COG0456	acetyltransferase
GSH73_RS03085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GSH73_RS03095	COG0488	(ABC) transporter
GSH73_RS03105	COG1360	Flagellar Motor Protein
GSH73_RS03115	COG1914	H( )-stimulated, divalent metal cation uptake system
GSH73_RS03145	COG1811	Na channel or pump
GSH73_RS03160	COG0411	ABC transporter
GSH73_RS03170	COG0559	Belongs to the binding-protein-dependent transport system permease family
GSH73_RS03185	COG4120	Belongs to the binding-protein-dependent transport system permease family
GSH73_RS03190	COG1136	(ABC) transporter
GSH73_RS03200	COG1404	Belongs to the peptidase S8 family
GSH73_RS03225	COG0459	protein refolding
GSH73_RS03230	COG0517	IMP dehydrogenase activity
GSH73_RS03230	COG0516	GMP reductase activity
GSH73_RS03235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GSH73_RS03235	COG0519	Catalyzes the synthesis of GMP from XMP
GSH73_RS03250	COG2252	PERMEase
GSH73_RS03255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GSH73_RS03260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GSH73_RS03265	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GSH73_RS03270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GSH73_RS03280	COG0138	bifunctional purine biosynthesis protein purh
GSH73_RS03285	COG0151	Belongs to the GarS family
GSH73_RS03290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GSH73_RS03295	COG1473	amidohydrolase
GSH73_RS03305	COG1854	S-ribosylhomocysteine lyase activity
GSH73_RS03320	COG2011	ABC-type metal ion transport system permease component
GSH73_RS03325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GSH73_RS03330	COG3711	transcriptional antiterminator
GSH73_RS03345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GSH73_RS03350	COG1447	Phosphotransferase system cellobiose-specific component IIA
GSH73_RS03355	COG4496	protein, YerC YecD
GSH73_RS03370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GSH73_RS03380	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GSH73_RS03385	COG4166	transmembrane transport
GSH73_RS03390	COG0601	transmembrane transport
GSH73_RS03395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSH73_RS03400	COG0444	Belongs to the ABC transporter superfamily
GSH73_RS03405	COG4608	Belongs to the ABC transporter superfamily
GSH73_RS03410	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSH73_RS03415	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GSH73_RS03470	COG1132	(ABC) transporter
GSH73_RS03475	COG0730	response to heat
GSH73_RS03495	COG0457	Tetratricopeptide repeat
GSH73_RS03495	COG0463	Glycosyl transferase, family 2
GSH73_RS03505	COG1309	transcriptional regulator
GSH73_RS03510	COG1511	domain protein
GSH73_RS03515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GSH73_RS03525	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GSH73_RS03535	COG0778	Nitroreductase
GSH73_RS03545	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GSH73_RS03565	COG1131	(ABC) transporter
GSH73_RS03570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GSH73_RS03580	COG0210	DNA helicase
GSH73_RS03595	COG0564	pseudouridine synthase activity
GSH73_RS03675	COG1592	Rubrerythrin
GSH73_RS03675	COG1773	rubredoxin
GSH73_RS03680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GSH73_RS03685	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GSH73_RS03685	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GSH73_RS03690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSH73_RS03690	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSH73_RS03700	COG3716	PTS system mannose fructose sorbose family IID component
GSH73_RS03705	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSH73_RS03715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GSH73_RS03745	COG1067	ATP-dependent peptidase activity
GSH73_RS03750	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GSH73_RS03760	COG2720	vancomycin resistance protein
GSH73_RS03765	COG0735	belongs to the Fur family
GSH73_RS03770	COG0561	phosphatase activity
GSH73_RS03775	COG1254	Belongs to the acylphosphatase family
GSH73_RS03780	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GSH73_RS03795	COG0126	phosphoglycerate kinase activity
GSH73_RS03800	COG0149	triose-phosphate isomerase activity
GSH73_RS03810	COG0148	phosphopyruvate hydratase activity
GSH73_RS03820	COG1342	Belongs to the UPF0251 family
GSH73_RS03825	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GSH73_RS03830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GSH73_RS03835	COG0358	DNA primase activity
GSH73_RS03840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GSH73_RS03855	COG2384	SAM-dependent methyltransferase
GSH73_RS03860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GSH73_RS03870	COG0482	sulfurtransferase activity
GSH73_RS03875	COG0813	purine-nucleoside phosphorylase activity
GSH73_RS03880	COG1482	cell wall glycoprotein biosynthetic process
GSH73_RS03920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GSH73_RS03925	COG1956	GAF domain-containing protein
GSH73_RS03930	COG1704	LemA family
GSH73_RS03940	COG1902	pentaerythritol trinitrate reductase activity
GSH73_RS03945	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GSH73_RS03960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GSH73_RS03965	COG1278	Cold shock
GSH73_RS03995	COG0582	viral genome integration into host DNA
GSH73_RS04010	COG1396	sequence-specific DNA binding
GSH73_RS04220	COG3409	Peptidoglycan-binding domain 1 protein
GSH73_RS04220	COG3757	hydrolase, family 25
GSH73_RS04240	COG0497	DNA recombination
GSH73_RS04280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSH73_RS04295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GSH73_RS04300	COG0367	asparagine synthase
GSH73_RS04305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GSH73_RS04320	COG2205	protein histidine kinase activity
GSH73_RS04325	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GSH73_RS04330	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GSH73_RS04335	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GSH73_RS04345	COG5002	protein histidine kinase activity
GSH73_RS04350	COG0745	RESPONSE REGULATOR receiver
GSH73_RS04355	COG3706	GGDEF domain
GSH73_RS04360	COG0586	Pfam SNARE associated Golgi protein
GSH73_RS04375	COG3773	Cell wall hydrolase
GSH73_RS04375	COG3409	Peptidoglycan-binding domain 1 protein
GSH73_RS04390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GSH73_RS04400	COG0739	heme binding
GSH73_RS04405	COG0772	Belongs to the SEDS family
GSH73_RS04415	COG1136	(ABC) transporter
GSH73_RS04420	COG0577	efflux transmembrane transporter activity
GSH73_RS04420	COG1136	(ABC) transporter
GSH73_RS04445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GSH73_RS04455	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GSH73_RS04465	COG0489	protein tyrosine kinase activity
GSH73_RS04470	COG2894	cell division
GSH73_RS04480	COG1234	tRNA 3'-trailer cleavage
GSH73_RS04490	COG0745	RESPONSE REGULATOR receiver
GSH73_RS04495	COG5002	protein histidine kinase activity
GSH73_RS04505	COG2814	Major facilitator Superfamily
GSH73_RS04510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GSH73_RS04515	COG0390	transport system, permease component
GSH73_RS04520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSH73_RS04530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GSH73_RS04540	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GSH73_RS04545	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GSH73_RS04555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GSH73_RS04570	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GSH73_RS04575	COG0569	domain protein
GSH73_RS04585	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GSH73_RS04600	COG0346	lactoylglutathione lyase activity
GSH73_RS04615	COG1609	Transcriptional regulator
GSH73_RS04620	COG2942	2-epimerase
GSH73_RS04625	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GSH73_RS04635	COG1609	Transcriptional regulator
GSH73_RS04645	COG1175	transmembrane transport
GSH73_RS04660	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GSH73_RS04665	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GSH73_RS04685	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GSH73_RS04685	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GSH73_RS04695	COG3414	Phosphotransferase system galactitol-specific IIB component
GSH73_RS04700	COG3775	system Galactitol-specific IIC component
GSH73_RS04735	COG1940	carbohydrate kinase activity
GSH73_RS04750	COG1175	transmembrane transport
GSH73_RS04755	COG0395	ABC-type sugar transport system, permease component
GSH73_RS04760	COG3387	PFAM Glycoside hydrolase 15-related
GSH73_RS04770	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GSH73_RS04775	COG1737	Transcriptional regulator
GSH73_RS04780	COG1940	carbohydrate kinase activity
GSH73_RS04785	COG1653	transport
GSH73_RS04795	COG0395	ABC-type sugar transport system, permease component
GSH73_RS04805	COG0445	tRNA wobble uridine modification
GSH73_RS04820	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GSH73_RS04835	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GSH73_RS04840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSH73_RS04850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GSH73_RS04855	COG0514	ATP-dependent DNA helicase (RecQ)
GSH73_RS04880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GSH73_RS04910	COG3275	phosphorelay sensor kinase activity
GSH73_RS04915	COG3279	Response regulator of the LytR AlgR family
GSH73_RS04920	COG1966	Carbon starvation protein
GSH73_RS04950	COG5002	protein histidine kinase activity
GSH73_RS04960	COG0531	amino acid
GSH73_RS04970	COG1609	Transcriptional regulator
GSH73_RS04975	COG1653	transport
GSH73_RS04980	COG1175	transmembrane transport
GSH73_RS04985	COG0395	ABC-type sugar transport system, permease component
GSH73_RS05005	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GSH73_RS05020	COG1132	(ABC) transporter
GSH73_RS05030	COG0352	thiamine-phosphate diphosphorylase activity
GSH73_RS05030	COG0351	phosphomethylpyrimidine kinase
GSH73_RS05045	COG0352	thiamine-phosphate diphosphorylase activity
GSH73_RS05060	COG1433	Dinitrogenase iron-molybdenum cofactor
GSH73_RS05060	COG0535	radical SAM domain protein
GSH73_RS05065	COG1433	Dinitrogenase iron-molybdenum cofactor
GSH73_RS05065	COG0535	radical SAM domain protein
GSH73_RS05070	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GSH73_RS05090	COG0347	Belongs to the P(II) protein family
GSH73_RS05095	COG0347	Belongs to the P(II) protein family
GSH73_RS05120	COG0559	Belongs to the binding-protein-dependent transport system permease family
GSH73_RS05130	COG0411	ABC transporter
GSH73_RS05140	COG0725	ABC transporter, periplasmic molybdate-binding protein
GSH73_RS05145	COG4149	molybdate abc transporter
GSH73_RS05155	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GSH73_RS05165	COG2508	Transcriptional regulator
GSH73_RS05165	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GSH73_RS05190	COG0004	ammonium transporteR
GSH73_RS05200	COG0004	ammonium transporteR
GSH73_RS05205	COG0347	Belongs to the P(II) protein family
GSH73_RS05210	COG0840	transmembrane signaling receptor activity
GSH73_RS05215	COG0367	asparagine synthase
GSH73_RS05230	COG0745	RESPONSE REGULATOR receiver
GSH73_RS05245	COG4399	Belongs to the UPF0754 family
GSH73_RS05245	COG4399	Belongs to the UPF0754 family
GSH73_RS05250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GSH73_RS05260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GSH73_RS05265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GSH73_RS05270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GSH73_RS05275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GSH73_RS05280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GSH73_RS05285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GSH73_RS05290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSH73_RS05290	COG0072	phenylalanine-tRNA ligase activity
GSH73_RS05300	COG0826	peptidase U32
GSH73_RS05305	COG1193	negative regulation of DNA recombination
GSH73_RS05330	COG2197	response regulator
GSH73_RS05335	COG1362	aminopeptidase activity
GSH73_RS05340	COG2340	Cysteine-rich secretory protein family
GSH73_RS05360	COG0280	phosphate acetyltransferase
GSH73_RS05370	COG3426	butyrate kinase activity
GSH73_RS05405	COG0531	amino acid
GSH73_RS05410	COG0006	proline dipeptidase activity
GSH73_RS05425	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GSH73_RS05435	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GSH73_RS05435	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GSH73_RS05445	COG0346	lactoylglutathione lyase activity
GSH73_RS05450	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GSH73_RS05460	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GSH73_RS05460	COG0674	pyruvate-flavodoxin oxidoreductase activity
GSH73_RS05465	COG1013	pyruvate-flavodoxin oxidoreductase activity
GSH73_RS05480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GSH73_RS05485	COG4475	Protein of unknown function (DUF436)
GSH73_RS05490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GSH73_RS05495	COG2608	mercury ion transmembrane transporter activity
GSH73_RS05510	COG1388	LysM domain
GSH73_RS05510	COG3858	chitin binding
GSH73_RS05515	COG1983	PspC domain protein
GSH73_RS05520	COG1113	amino acid transport
GSH73_RS05550	COG0237	dephospho-CoA kinase activity
GSH73_RS05555	COG0741	lytic transglycosylase activity
GSH73_RS05560	COG2707	UPF0756 membrane protein
GSH73_RS05590	COG0791	NLP P60 protein
GSH73_RS05600	COG0741	lytic transglycosylase activity
GSH73_RS05620	COG2878	Part of a membrane complex involved in electron transport
GSH73_RS05665	COG0424	maF-like protein
GSH73_RS05670	COG2003	Belongs to the UPF0758 family
GSH73_RS05675	COG1077	Cell shape determining protein MreB Mrl
GSH73_RS05695	COG0850	regulation of cytokinetic process
GSH73_RS05700	COG2894	cell division
GSH73_RS05705	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GSH73_RS05710	COG0772	Belongs to the SEDS family
GSH73_RS05720	COG1388	LysM domain
GSH73_RS05720	COG0739	heme binding
GSH73_RS05725	COG1994	Peptidase M50
GSH73_RS05725	COG0517	IMP dehydrogenase activity
GSH73_RS05740	COG1530	ribonuclease E activity
GSH73_RS05745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GSH73_RS05755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GSH73_RS05765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GSH73_RS05770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GSH73_RS05775	COG1713	HD superfamily hydrolase involved in NAD metabolism
GSH73_RS05780	COG0799	negative regulation of ribosome biogenesis
GSH73_RS05785	COG2964	Protein conserved in bacteria
GSH73_RS05790	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
GSH73_RS05795	COG1686	Belongs to the peptidase S11 family
GSH73_RS05800	COG1596	polysaccharide export
GSH73_RS05800	COG1555	photosystem II stabilization
GSH73_RS05810	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GSH73_RS05815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GSH73_RS05820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GSH73_RS05830	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GSH73_RS05835	COG1175	transmembrane transport
GSH73_RS05840	COG0395	ABC-type sugar transport system, permease component
GSH73_RS05845	COG1653	transport
GSH73_RS05860	COG0493	'glutamate synthase
GSH73_RS05880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GSH73_RS05885	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GSH73_RS05910	COG1131	(ABC) transporter
GSH73_RS05925	COG0546	phosphoglycolate phosphatase activity
GSH73_RS05935	COG2333	competence protein COMEC
GSH73_RS05935	COG0658	competence protein
GSH73_RS05945	COG0268	Binds directly to 16S ribosomal RNA
GSH73_RS05955	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GSH73_RS05965	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSH73_RS05975	COG0438	transferase activity, transferring glycosyl groups
GSH73_RS05985	COG0481	GTPase activity
GSH73_RS05990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GSH73_RS06000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GSH73_RS06005	COG0443	Heat shock 70 kDa protein
GSH73_RS06010	COG0484	heat shock protein binding
GSH73_RS06015	COG2264	protein methyltransferase activity
GSH73_RS06020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GSH73_RS06025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GSH73_RS06030	COG0537	adenosine 5'-monophosphoramidase activity
GSH73_RS06035	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GSH73_RS06040	COG1610	YqeY-like protein
GSH73_RS06055	COG1702	phosphate starvation-inducible protein PhoH
GSH73_RS06060	COG1480	7TM receptor with intracellular HD hydrolase
GSH73_RS06065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GSH73_RS06070	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GSH73_RS06075	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GSH73_RS06095	COG0423	glycine-tRNA ligase activity
GSH73_RS06100	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GSH73_RS06105	COG0574	Belongs to the PEP-utilizing enzyme family
GSH73_RS06105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GSH73_RS06135	COG0557	exoribonuclease II activity
GSH73_RS06170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GSH73_RS06175	COG1799	cell septum assembly
GSH73_RS06185	COG2302	S4 RNA-binding domain
GSH73_RS06190	COG3599	regulation of cell shape
GSH73_RS06200	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GSH73_RS06225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GSH73_RS06225	COG0512	Glutamine amidotransferase of anthranilate synthase
GSH73_RS06230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GSH73_RS06235	COG0134	indole-3-glycerol-phosphate synthase activity
GSH73_RS06255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GSH73_RS06275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GSH73_RS06285	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GSH73_RS06290	COG0564	pseudouridine synthase activity
GSH73_RS06295	COG0124	histidyl-tRNA synthetase
GSH73_RS06310	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GSH73_RS06315	COG1937	Protein conserved in bacteria
GSH73_RS06320	COG3118	belongs to the thioredoxin family
GSH73_RS06345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GSH73_RS06350	COG1959	2 iron, 2 sulfur cluster binding
GSH73_RS06390	COG0628	permease
GSH73_RS06395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GSH73_RS06400	COG4472	Bacterial protein of unknown function (DUF965)
GSH73_RS06410	COG3906	Belongs to the UPF0473 family
GSH73_RS06415	COG0735	belongs to the Fur family
GSH73_RS06420	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GSH73_RS06425	COG3679	Belongs to the UPF0342 family
GSH73_RS06430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GSH73_RS06445	COG0768	penicillin binding
GSH73_RS06455	COG0358	DNA primase activity
GSH73_RS06485	COG0582	viral genome integration into host DNA
GSH73_RS06490	COG1191	sigma factor activity
GSH73_RS06500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GSH73_RS06515	COG1459	type II secretion system
GSH73_RS06525	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GSH73_RS06570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GSH73_RS06575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GSH73_RS06580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GSH73_RS06585	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GSH73_RS06590	COG0006	proline dipeptidase activity
GSH73_RS06595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GSH73_RS06605	COG3854	ATPases associated with a variety of cellular activities
GSH73_RS06645	COG1302	Protein conserved in bacteria
GSH73_RS06650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GSH73_RS06655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GSH73_RS06660	COG1570	exodeoxyribonuclease VII activity
GSH73_RS06665	COG1722	exodeoxyribonuclease VII activity
GSH73_RS06670	COG0142	geranyltranstransferase activity
GSH73_RS06680	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GSH73_RS06685	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GSH73_RS06690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GSH73_RS06695	COG1438	arginine binding
GSH73_RS06700	COG0497	DNA recombination
GSH73_RS06705	COG0750	zinc metalloprotease
GSH73_RS06740	COG0494	nUDIX hydrolase
GSH73_RS06745	COG1379	DNA repair
GSH73_RS06750	COG1300	Membrane
GSH73_RS06755	COG4974	Belongs to the 'phage' integrase family
GSH73_RS06760	COG1686	Belongs to the peptidase S11 family
GSH73_RS06770	COG2172	sigma factor antagonist activity
GSH73_RS06775	COG1191	sigma factor activity
GSH73_RS06780	COG3360	Dodecin
GSH73_RS06800	COG0617	tRNA 3'-terminal CCA addition
GSH73_RS06805	COG1994	Peptidase M50
GSH73_RS06810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GSH73_RS06815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GSH73_RS06825	COG3874	Sporulation protein YtfJ
GSH73_RS06830	COG1686	Belongs to the peptidase S11 family
GSH73_RS06840	COG0445	tRNA wobble uridine modification
GSH73_RS06845	COG1187	pseudouridine synthase activity
GSH73_RS06855	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GSH73_RS06860	COG0010	Belongs to the arginase family
GSH73_RS06870	COG1388	LysM domain
GSH73_RS06880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GSH73_RS06895	COG2081	HI0933 family
GSH73_RS06905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GSH73_RS06915	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GSH73_RS06920	COG0539	negative regulation of cytoplasmic translation
GSH73_RS06925	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GSH73_RS06930	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GSH73_RS06945	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GSH73_RS06950	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GSH73_RS06955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GSH73_RS06960	COG1923	regulation of RNA biosynthetic process
GSH73_RS06965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GSH73_RS06970	COG0328	RNA-DNA hybrid ribonuclease activity
GSH73_RS06975	COG4974	Belongs to the 'phage' integrase family
GSH73_RS06980	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GSH73_RS06985	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GSH73_RS06990	COG0464	growth
GSH73_RS06995	COG0017	Asparaginyl-tRNA synthetase
GSH73_RS07010	COG0613	PHP domain protein
GSH73_RS07015	COG2359	stage V sporulation protein S
GSH73_RS07020	COG1692	metallophosphoesterase
GSH73_RS07030	COG0419	ATPase involved in DNA repair
GSH73_RS07055	COG2137	regulation of response to DNA damage stimulus
GSH73_RS07060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GSH73_RS07065	COG1058	Belongs to the CinA family
GSH73_RS07065	COG1546	Belongs to the CinA family
GSH73_RS07070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GSH73_RS07075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GSH73_RS07080	COG1674	ftsk spoiiie
GSH73_RS07090	COG0740	serine-type endopeptidase activity
GSH73_RS07095	COG0527	aspartate kinase activity
GSH73_RS07105	COG0756	dUTP diphosphatase activity
GSH73_RS07110	COG0612	Peptidase, M16
GSH73_RS07115	COG0726	polysaccharide deacetylase
GSH73_RS07120	COG1185	polyribonucleotide nucleotidyltransferase activity
GSH73_RS07125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GSH73_RS07135	COG0196	riboflavin kinase activity
GSH73_RS07140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GSH73_RS07145	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GSH73_RS07150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GSH73_RS07165	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GSH73_RS07170	COG0195	Participates in both transcription termination and antitermination
GSH73_RS07175	COG0779	Required for maturation of 30S ribosomal subunits
GSH73_RS07180	COG2176	DNA-directed DNA polymerase activity
GSH73_RS07185	COG0463	Glycosyl transferase, family 2
GSH73_RS07190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GSH73_RS07195	COG0750	zinc metalloprotease
GSH73_RS07200	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GSH73_RS07205	COG4589	Belongs to the CDS family
GSH73_RS07210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GSH73_RS07215	COG0233	cytoplasmic translational termination
GSH73_RS07220	COG0528	UMP kinase activity
GSH73_RS07225	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GSH73_RS07230	COG0052	Belongs to the universal ribosomal protein uS2 family
GSH73_RS07245	COG1191	sigma factor activity
GSH73_RS07250	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GSH73_RS07255	COG1776	CheC inhibitor of MCP methylation
GSH73_RS07260	COG0835	chemotaxis
GSH73_RS07265	COG0643	Histidine kinase
GSH73_RS07265	COG2198	Histidine kinase
GSH73_RS07275	COG0455	bacterial-type flagellum organization
GSH73_RS07285	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GSH73_RS07290	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GSH73_RS07295	COG1684	flagellar biosynthetic protein fliR
GSH73_RS07300	COG1987	bacterial-type flagellum assembly
GSH73_RS07305	COG1338	Plays a role in the flagellum-specific transport system
GSH73_RS07315	COG2201	protein-glutamate methylesterase activity
GSH73_RS07320	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GSH73_RS07320	COG1776	CheC inhibitor of MCP methylation
GSH73_RS07325	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GSH73_RS07330	COG1580	Controls the rotational direction of flagella during chemotaxis
GSH73_RS07345	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GSH73_RS07365	COG1157	protein secretion by the type III secretion system
GSH73_RS07375	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GSH73_RS07380	COG1766	The M ring may be actively involved in energy transduction
GSH73_RS07385	COG1677	Flagellar hook-basal body complex protein FliE
GSH73_RS07390	COG1558	bacterial-type flagellum-dependent cell motility
GSH73_RS07395	COG1815	bacterial-type flagellum-dependent cell motility
GSH73_RS07405	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GSH73_RS07410	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GSH73_RS07415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GSH73_RS07420	COG0758	DNA mediated transformation
GSH73_RS07420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GSH73_RS07425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GSH73_RS07430	COG0792	nuclease activity
GSH73_RS07435	COG0180	Tryptophanyl-tRNA synthetase
GSH73_RS07440	COG0606	chelatase, subunit chli
GSH73_RS07450	COG0335	large ribosomal subunit rRNA binding
GSH73_RS07455	COG0336	Belongs to the RNA methyltransferase TrmD family
GSH73_RS07460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GSH73_RS07465	COG1837	Belongs to the UPF0109 family
GSH73_RS07470	COG0228	four-way junction DNA binding
GSH73_RS07475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GSH73_RS07480	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GSH73_RS07485	COG0552	protein localization to endoplasmic reticulum
GSH73_RS07490	COG1196	nuclear chromosome segregation
GSH73_RS07495	COG2359	stage V sporulation protein S
GSH73_RS07500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GSH73_RS07505	COG0571	ribonuclease III activity
GSH73_RS07510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GSH73_RS07515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSH73_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
GSH73_RS07525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GSH73_RS07530	COG2070	2-Nitropropane dioxygenase
GSH73_RS07535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GSH73_RS07540	COG0416	fatty acid biosynthetic process
GSH73_RS07545	COG2030	dehydratase
GSH73_RS07550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GSH73_RS07555	COG1399	metal-binding, possibly nucleic acid-binding protein
GSH73_RS07560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GSH73_RS07565	COG0280	phosphate acetyltransferase
GSH73_RS07575	COG3314	Sporulation integral membrane protein YlbJ
GSH73_RS07585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GSH73_RS07590	COG0742	ribosomal rna small subunit methyltransferase
GSH73_RS07605	COG1307	EDD domain protein, DegV family
GSH73_RS07610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GSH73_RS07615	COG1461	Dihydroxyacetone kinase
GSH73_RS07620	COG1302	Protein conserved in bacteria
GSH73_RS07640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GSH73_RS07645	COG1162	GTPase activity
GSH73_RS07650	COG2815	serine threonine protein kinase
GSH73_RS07650	COG0515	serine threonine protein kinase
GSH73_RS07655	COG0631	protein serine/threonine phosphatase activity
GSH73_RS07660	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GSH73_RS07665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GSH73_RS07665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GSH73_RS07670	COG2738	Putative neutral zinc metallopeptidase
GSH73_RS07680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GSH73_RS07685	COG0242	peptide deformylase activity
GSH73_RS07690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GSH73_RS07695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GSH73_RS07705	COG0194	GDP metabolic process
GSH73_RS07715	COG1561	YicC-like family, N-terminal region
GSH73_RS07720	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GSH73_RS07760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GSH73_RS07765	COG0167	dihydroorotate dehydrogenase activity
GSH73_RS07770	COG0543	2 iron, 2 sulfur cluster binding
GSH73_RS07780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GSH73_RS07785	COG0540	Belongs to the ATCase OTCase family
GSH73_RS07790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GSH73_RS07805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSH73_RS07815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GSH73_RS07820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GSH73_RS07825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GSH73_RS07825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GSH73_RS07840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSH73_RS07845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSH73_RS07870	COG0343	queuine tRNA-ribosyltransferase activity
GSH73_RS07875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GSH73_RS07880	COG2247	cell wall binding repeat
GSH73_RS07880	COG2385	sporulation resulting in formation of a cellular spore
GSH73_RS07890	COG2255	four-way junction helicase activity
GSH73_RS07895	COG0632	four-way junction helicase activity
GSH73_RS07900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GSH73_RS07910	COG0835	chemotaxis
GSH73_RS07915	COG0217	transcriptional regulatory protein
GSH73_RS07920	COG0730	response to heat
GSH73_RS07940	COG1739	Uncharacterized protein family UPF0029
GSH73_RS07945	COG0494	nUDIX hydrolase
GSH73_RS07955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GSH73_RS07980	COG0175	sulfate reduction
GSH73_RS07985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GSH73_RS08000	COG0175	sulfate reduction
GSH73_RS08020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GSH73_RS08035	COG0113	porphobilinogen synthase activity
GSH73_RS08040	COG1648	precorrin-2 dehydrogenase activity
GSH73_RS08040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GSH73_RS08045	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GSH73_RS08055	COG0181	hydroxymethylbilane synthase activity
GSH73_RS08060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GSH73_RS08070	COG0444	Belongs to the ABC transporter superfamily
GSH73_RS08085	COG4166	transmembrane transport
GSH73_RS08095	COG2078	PFAM AMMECR1 domain protein
GSH73_RS08095	COG3885	ferrous iron binding
GSH73_RS08100	COG0789	Transcriptional regulator
GSH73_RS08105	COG0477	Major facilitator Superfamily
GSH73_RS08110	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GSH73_RS08115	COG1982	Orn Lys Arg decarboxylase major
GSH73_RS08125	COG2205	protein histidine kinase activity
GSH73_RS08140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSH73_RS08145	COG0785	Cytochrome C biogenesis protein
GSH73_RS08150	COG0363	glucosamine-6-phosphate deaminase activity
GSH73_RS08155	COG1940	carbohydrate kinase activity
GSH73_RS08180	COG2119	membrane
GSH73_RS08185	COG3773	Cell wall hydrolase
GSH73_RS08185	COG3409	Peptidoglycan-binding domain 1 protein
GSH73_RS08190	COG5002	protein histidine kinase activity
GSH73_RS08195	COG0745	RESPONSE REGULATOR receiver
GSH73_RS08200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GSH73_RS08205	COG0287	Prephenate dehydrogenase
GSH73_RS08210	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GSH73_RS08215	COG1605	Chorismate mutase
GSH73_RS08215	COG0077	Prephenate dehydratase
GSH73_RS08220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GSH73_RS08225	COG1760	l-serine dehydratase
GSH73_RS08235	COG1164	Oligoendopeptidase f
GSH73_RS08245	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GSH73_RS08250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GSH73_RS08260	COG0426	domain, Protein
GSH73_RS08265	COG3069	C4-dicarboxylate transmembrane transporter activity
GSH73_RS08280	COG1968	undecaprenyl-diphosphatase activity
GSH73_RS08285	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GSH73_RS08295	COG0584	glycerophosphoryl diester phosphodiesterase
GSH73_RS08325	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GSH73_RS08360	COG0704	Plays a role in the regulation of phosphate uptake
GSH73_RS08365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GSH73_RS08370	COG0581	inorganic phosphate transmembrane transporter activity
GSH73_RS08375	COG0573	inorganic phosphate transmembrane transporter activity
GSH73_RS08380	COG0840	transmembrane signaling receptor activity
GSH73_RS08385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GSH73_RS08390	COG5002	protein histidine kinase activity
GSH73_RS08395	COG0745	RESPONSE REGULATOR receiver
GSH73_RS08405	COG1873	PFAM PRC-barrel domain
GSH73_RS08410	COG1191	sigma factor activity
GSH73_RS08415	COG1191	sigma factor activity
GSH73_RS08425	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GSH73_RS08430	COG0849	cell division
GSH73_RS08435	COG3856	small basic protein
GSH73_RS08450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GSH73_RS08455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GSH73_RS08460	COG0772	Belongs to the SEDS family
GSH73_RS08470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GSH73_RS08475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GSH73_RS08480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GSH73_RS08485	COG0768	penicillin binding
GSH73_RS08505	COG0612	Peptidase, M16
GSH73_RS08510	COG0612	Peptidase, M16
GSH73_RS08520	COG0012	GTP binding
GSH73_RS08525	COG0301	tRNA thio-modification
GSH73_RS08550	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GSH73_RS08560	COG1937	Protein conserved in bacteria
GSH73_RS08565	COG0438	transferase activity, transferring glycosyl groups
GSH73_RS08600	COG0438	transferase activity, transferring glycosyl groups
GSH73_RS08605	COG0739	heme binding
GSH73_RS08615	COG3858	chitin binding
GSH73_RS08615	COG1388	LysM domain
GSH73_RS08630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSH73_RS08635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GSH73_RS08650	COG1252	NADH dehydrogenase
GSH73_RS08655	COG0745	RESPONSE REGULATOR receiver
GSH73_RS08655	COG3706	GGDEF domain
GSH73_RS08675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GSH73_RS08680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSH73_RS08685	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GSH73_RS08690	COG2171	N-acyltransferase activity
GSH73_RS08705	COG0726	polysaccharide deacetylase
GSH73_RS08710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GSH73_RS08730	COG2182	Extracellular solute-binding protein
GSH73_RS08740	COG0395	ABC-type sugar transport system, permease component
GSH73_RS08745	COG1175	transmembrane transport
GSH73_RS08760	COG1609	Transcriptional regulator
GSH73_RS08780	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GSH73_RS08810	COG0285	dihydrofolate synthase activity
GSH73_RS08820	COG0525	valine-tRNA ligase activity
GSH73_RS08825	COG1268	BioY protein
GSH73_RS08830	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GSH73_RS08835	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GSH73_RS08840	COG1691	(AIR) carboxylase
GSH73_RS08845	COG1606	tRNA processing
GSH73_RS08850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GSH73_RS08860	COG0671	phosphoesterase, PA-phosphatase related
GSH73_RS08865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GSH73_RS08870	COG0426	domain, Protein
GSH73_RS08890	COG0105	UTP biosynthetic process
GSH73_RS08900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GSH73_RS08910	COG3949	Membrane
GSH73_RS08920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GSH73_RS08945	COG1942	4-Oxalocrotonate Tautomerase
GSH73_RS08955	COG1136	(ABC) transporter
GSH73_RS08975	COG0395	ABC-type sugar transport system, permease component
GSH73_RS08980	COG1175	transmembrane transport
GSH73_RS08985	COG1653	transport
GSH73_RS09005	COG0395	ABC-type sugar transport system, permease component
GSH73_RS09010	COG4209	transmembrane transport
GSH73_RS09020	COG3275	phosphorelay sensor kinase activity
GSH73_RS09025	COG4753	response regulator
GSH73_RS09025	COG2207	Transcriptional regulator
GSH73_RS09025	COG2207	Transcriptional regulator
GSH73_RS09025	COG4753	response regulator
GSH73_RS09030	COG3458	cephalosporin-C deacetylase activity
GSH73_RS09035	COG3664	PFAM glycoside hydrolase family 39
GSH73_RS09050	COG0673	inositol 2-dehydrogenase activity
GSH73_RS09065	COG0395	ABC-type sugar transport system, permease component
GSH73_RS09070	COG4209	transmembrane transport
GSH73_RS09125	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GSH73_RS09130	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GSH73_RS09140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GSH73_RS09145	COG1116	anion transmembrane transporter activity
GSH73_RS09150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GSH73_RS09155	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GSH73_RS09155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GSH73_RS09170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GSH73_RS09175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GSH73_RS09180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GSH73_RS09185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GSH73_RS09190	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GSH73_RS09195	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GSH73_RS09200	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GSH73_RS09205	COG0356	it plays a direct role in the translocation of protons across the membrane
GSH73_RS09210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GSH73_RS09215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GSH73_RS09225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GSH73_RS09230	COG0740	serine-type endopeptidase activity
GSH73_RS09235	COG0544	peptidyl-prolyl cis-trans isomerase activity
GSH73_RS09240	COG1234	tRNA 3'-trailer cleavage
GSH73_RS09245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GSH73_RS09250	COG0789	Transcriptional regulator
GSH73_RS09275	COG0656	L-ascorbic acid biosynthetic process
GSH73_RS09280	COG0667	Aldo Keto reductase
GSH73_RS09300	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GSH73_RS09305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GSH73_RS09310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GSH73_RS09325	COG3546	catalase activity
GSH73_RS09330	COG0646	methionine synthase
GSH73_RS09330	COG1410	methionine synthase
GSH73_RS09335	COG0646	methionine synthase
GSH73_RS09335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GSH73_RS09370	COG0778	Nitroreductase
GSH73_RS09375	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GSH73_RS09380	COG2195	Cleaves the N-terminal amino acid of tripeptides
GSH73_RS09385	COG1073	alpha beta
GSH73_RS09385	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GSH73_RS09385	COG3064	Membrane
GSH73_RS09395	COG1199	ATP-dependent helicase activity
GSH73_RS09395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GSH73_RS09410	COG0778	Nitroreductase
GSH73_RS09435	COG5002	protein histidine kinase activity
GSH73_RS09445	COG2814	Major facilitator Superfamily
GSH73_RS09450	COG1846	Transcriptional regulator
GSH73_RS09475	COG2801	Transposase and inactivated derivatives
GSH73_RS09495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GSH73_RS09505	COG0824	Thioesterase
GSH73_RS09515	COG0205	6-phosphofructokinase activity
GSH73_RS09530	COG4109	DRTGG domain
GSH73_RS09535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSH73_RS09540	COG1481	regulation of sporulation
GSH73_RS09555	COG0366	Alpha amylase catalytic
GSH73_RS09560	COG1426	Protein conserved in bacteria
GSH73_RS09575	COG3833	ABC-type maltose transport systems, permease component
GSH73_RS09580	COG1175	transmembrane transport
GSH73_RS09590	COG0840	transmembrane signaling receptor activity
GSH73_RS09630	COG1660	Displays ATPase and GTPase activities
GSH73_RS09640	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GSH73_RS09645	COG2217	Heavy metal translocating P-type atpase
GSH73_RS09670	COG1131	(ABC) transporter
GSH73_RS09695	COG2226	methyltransferase
GSH73_RS09705	COG1914	H( )-stimulated, divalent metal cation uptake system
GSH73_RS09725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GSH73_RS09725	COG1796	DNA polymerase
GSH73_RS09735	COG2608	mercury ion transmembrane transporter activity
GSH73_RS09740	COG0644	oxidoreductase
GSH73_RS09755	COG2755	lipolytic protein G-D-S-L family
GSH73_RS09755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GSH73_RS09775	COG1388	LysM domain
GSH73_RS09775	COG0791	NLP P60 protein
GSH73_RS09780	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GSH73_RS09785	COG3285	dna ligase
GSH73_RS09785	COG1793	dna ligase
GSH73_RS09790	COG0768	penicillin binding
GSH73_RS09800	COG1477	protein flavinylation
GSH73_RS09805	COG0726	polysaccharide deacetylase
GSH73_RS09830	COG1940	carbohydrate kinase activity
GSH73_RS09835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GSH73_RS09840	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GSH73_RS09845	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GSH73_RS09870	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GSH73_RS09875	COG0371	Dehydrogenase
GSH73_RS09880	COG1609	Transcriptional regulator
GSH73_RS09890	COG0235	Class ii aldolase
GSH73_RS09895	COG1069	ribulokinase activity
GSH73_RS09900	COG2160	L-arabinose isomerase activity
GSH73_RS09905	COG1172	Belongs to the binding-protein-dependent transport system permease family
GSH73_RS09910	COG1129	ABC transporter
GSH73_RS09925	COG3534	alpha-L-arabinofuranosidase
GSH73_RS09930	COG1501	Belongs to the glycosyl hydrolase 31 family
GSH73_RS09935	COG1874	Beta-galactosidase
GSH73_RS09955	COG0395	ABC-type sugar transport system, permease component
GSH73_RS09960	COG4209	transmembrane transport
GSH73_RS09970	COG2723	6-phospho-beta-galactosidase activity
GSH73_RS09990	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GSH73_RS09995	COG1447	Phosphotransferase system cellobiose-specific component IIA
GSH73_RS10000	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GSH73_RS10000	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GSH73_RS10005	COG3250	beta-galactosidase activity
GSH73_RS10010	COG0673	inositol 2-dehydrogenase activity
GSH73_RS10025	COG0673	inositol 2-dehydrogenase activity
GSH73_RS10030	COG1609	Transcriptional regulator
GSH73_RS10035	COG0318	PFAM AMP-dependent synthetase and ligase
GSH73_RS10040	COG1940	carbohydrate kinase activity
GSH73_RS10050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GSH73_RS10055	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GSH73_RS10055	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GSH73_RS10065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GSH73_RS10080	COG0768	penicillin binding
GSH73_RS10090	COG1716	ATPase activity
GSH73_RS10100	COG0556	nucleotide-excision repair
GSH73_RS10105	COG2045	Belongs to the ComB family
GSH73_RS10110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSH73_RS10115	COG0793	Belongs to the peptidase S41A family
GSH73_RS10120	COG0739	heme binding
GSH73_RS10125	COG2177	Part of the ABC transporter FtsEX involved in
GSH73_RS10130	COG2884	Cell division ATP-binding protein ftsE
GSH73_RS10135	COG3835	regulator
GSH73_RS10140	COG0067	glutamate synthase
GSH73_RS10145	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GSH73_RS10145	COG0069	glutamate synthase activity
GSH73_RS10150	COG0437	4 iron, 4 sulfur cluster binding
GSH73_RS10165	COG3842	ATPase activity
GSH73_RS10180	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GSH73_RS10200	COG1131	(ABC) transporter
GSH73_RS10220	COG0849	cell division
GSH73_RS10255	COG0443	Heat shock 70 kDa protein
GSH73_RS10265	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GSH73_RS10275	COG2376	Dihydroxyacetone kinase
GSH73_RS10280	COG3829	transcription factor binding
GSH73_RS10280	COG3290	protein histidine kinase activity
GSH73_RS10290	COG0446	pyridine nucleotide-disulphide oxidoreductase
GSH73_RS10300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GSH73_RS10305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GSH73_RS10320	COG0798	PFAM Bile acid sodium symporter
GSH73_RS10330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GSH73_RS10350	COG0640	Transcriptional regulator
GSH73_RS10375	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GSH73_RS10385	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GSH73_RS10390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GSH73_RS10400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GSH73_RS10405	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GSH73_RS10405	COG0140	phosphoribosyl-ATP diphosphatase activity
GSH73_RS10420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GSH73_RS10425	COG0131	Imidazoleglycerol-phosphate dehydratase
GSH73_RS10435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GSH73_RS10440	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GSH73_RS10445	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GSH73_RS10455	COG0330	HflC and HflK could
GSH73_RS10465	COG1725	Transcriptional regulator
GSH73_RS10470	COG3459	Glycosyltransferase 36 associated
GSH73_RS10475	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GSH73_RS10475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GSH73_RS10480	COG4124	Belongs to the glycosyl hydrolase 26 family
GSH73_RS10490	COG0395	ABC-type sugar transport system, permease component
GSH73_RS10495	COG1175	transmembrane transport
GSH73_RS10515	COG0395	ABC-type sugar transport system, permease component
GSH73_RS10525	COG1653	transport
GSH73_RS10530	COG1609	Transcriptional regulator
GSH73_RS10550	COG0673	inositol 2-dehydrogenase activity
GSH73_RS10560	COG1773	rubredoxin
GSH73_RS10570	COG0157	Belongs to the NadC ModD family
GSH73_RS10575	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GSH73_RS10580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GSH73_RS10590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GSH73_RS10595	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GSH73_RS10615	COG2337	Toxic component of a toxin-antitoxin (TA) module
GSH73_RS10625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GSH73_RS10635	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GSH73_RS10635	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GSH73_RS10650	COG0432	Pfam Uncharacterised protein family UPF0047
GSH73_RS10655	COG3973	AAA domain
GSH73_RS10670	COG2703	oxygen carrier activity
GSH73_RS10675	COG0561	phosphatase activity
GSH73_RS10685	COG0456	acetyltransferase
GSH73_RS10715	COG0640	Transcriptional regulator
GSH73_RS10765	COG3012	SEC-C Motif Domain Protein
GSH73_RS10870	COG1619	proteins homologs of microcin C7 resistance protein MccF
GSH73_RS10875	COG2226	methyltransferase
GSH73_RS10960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GSH73_RS11005	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GSH73_RS11015	COG1305	Transglutaminase-like
GSH73_RS11020	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GSH73_RS11025	COG0714	Associated with various cellular activities
GSH73_RS11035	COG3942	CHAP domain
GSH73_RS11035	COG1388	LysM domain
GSH73_RS11060	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GSH73_RS11075	COG1454	alcohol dehydrogenase
GSH73_RS11140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GSH73_RS11145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GSH73_RS11150	COG0101	tRNA pseudouridine synthase activity
GSH73_RS11155	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GSH73_RS11160	COG1122	ATPase activity
GSH73_RS11165	COG1122	ATPase activity
GSH73_RS11170	COG0203	ribosomal protein L17
GSH73_RS11175	COG0202	RNA polymerase activity
GSH73_RS11180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GSH73_RS11185	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GSH73_RS11190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GSH73_RS11195	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GSH73_RS11200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GSH73_RS11215	COG0563	adenylate kinase activity
GSH73_RS11220	COG0201	protein transport
GSH73_RS11225	COG0200	Binds to the 23S rRNA
GSH73_RS11230	COG1841	ribosomal large subunit assembly
GSH73_RS11235	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GSH73_RS11240	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GSH73_RS11250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GSH73_RS11260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GSH73_RS11265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GSH73_RS11270	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GSH73_RS11275	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GSH73_RS11280	COG0255	Belongs to the universal ribosomal protein uL29 family
GSH73_RS11285	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GSH73_RS11290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GSH73_RS11295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GSH73_RS11300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GSH73_RS11305	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GSH73_RS11310	COG0089	rRNA binding
GSH73_RS11315	COG0088	Forms part of the polypeptide exit tunnel
GSH73_RS11320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GSH73_RS11325	COG0051	transcription antitermination factor activity, RNA binding
GSH73_RS11335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GSH73_RS11340	COG0049	tRNA binding
GSH73_RS11345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GSH73_RS11350	COG1358	cellular component organization or biogenesis
GSH73_RS11355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GSH73_RS11360	COG0085	RNA polymerase activity
GSH73_RS11365	COG0222	ribosome binding
GSH73_RS11380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GSH73_RS11385	COG0250	Participates in transcription elongation, termination and antitermination
GSH73_RS11390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GSH73_RS11400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GSH73_RS11410	COG1595	DNA-templated transcription, initiation
GSH73_RS11415	COG3688	RNA-binding protein containing a PIN domain
GSH73_RS11430	COG0215	cysteine-tRNA ligase activity
GSH73_RS11435	COG1045	serine acetyltransferase
GSH73_RS11440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GSH73_RS11455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GSH73_RS11465	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GSH73_RS11470	COG4956	integral membrane protein (PIN domain superfamily)
GSH73_RS11480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GSH73_RS11485	COG0542	response to heat
GSH73_RS11490	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GSH73_RS11495	COG3880	PFAM UvrB UvrC protein
GSH73_RS11510	COG0281	malic enzyme
GSH73_RS11515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GSH73_RS11520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GSH73_RS11525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSH73_RS11530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSH73_RS11530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSH73_RS11530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSH73_RS11535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSH73_RS11535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSH73_RS11535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSH73_RS11540	COG3711	transcriptional antiterminator
GSH73_RS11540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSH73_RS11545	COG0745	RESPONSE REGULATOR receiver
GSH73_RS11545	COG3706	GGDEF domain
GSH73_RS11550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GSH73_RS11570	COG4224	UPF0291 protein
GSH73_RS11575	COG1489	DNA binding
GSH73_RS11580	COG0720	synthase
GSH73_RS11585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GSH73_RS11590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GSH73_RS11595	COG0302	gtp cyclohydrolase
GSH73_RS11600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GSH73_RS11605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GSH73_RS11610	COG5322	oxidoreductase activity
GSH73_RS11610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GSH73_RS11635	COG0697	spore germination
GSH73_RS11645	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GSH73_RS11650	COG4684	Psort location CytoplasmicMembrane, score
GSH73_RS11655	COG4770	biotin carboxylase activity
GSH73_RS11660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GSH73_RS11670	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GSH73_RS11675	COG3852	Histidine kinase
GSH73_RS11685	COG1917	Cupin 2, conserved barrel domain protein
GSH73_RS11685	COG4977	sequence-specific DNA binding
GSH73_RS11700	COG0037	tRNA processing
GSH73_RS11705	COG0515	serine threonine protein kinase
GSH73_RS11705	COG2815	serine threonine protein kinase
GSH73_RS11715	COG2208	phosphoserine phosphatase activity
GSH73_RS11725	COG2226	methyltransferase
GSH73_RS11750	COG2226	methyltransferase
GSH73_RS11760	COG3830	Belongs to the UPF0237 family
GSH73_RS11770	COG1595	DNA-templated transcription, initiation
GSH73_RS11780	COG1131	(ABC) transporter
GSH73_RS11810	COG1309	transcriptional regulator
GSH73_RS11820	COG1131	(ABC) transporter
GSH73_RS11825	COG0842	Transport permease protein
GSH73_RS11835	COG2233	PERMEase
GSH73_RS11845	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSH73_RS11860	COG0840	transmembrane signaling receptor activity
GSH73_RS11890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GSH73_RS11890	COG0248	Ppx GppA phosphatase
GSH73_RS11895	COG1098	S1 RNA binding domain
GSH73_RS11925	COG2385	sporulation resulting in formation of a cellular spore
GSH73_RS11930	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GSH73_RS11935	COG0776	regulation of translation
GSH73_RS11940	COG3956	TIGRFAM MazG family protein
GSH73_RS11960	COG1027	Aspartate ammonia-lyase
GSH73_RS11965	COG2033	superoxide reductase activity
GSH73_RS11970	COG1914	H( )-stimulated, divalent metal cation uptake system
GSH73_RS11975	COG1321	iron dependent repressor
GSH73_RS11980	COG0586	Pfam SNARE associated Golgi protein
GSH73_RS11985	COG0446	pyridine nucleotide-disulphide oxidoreductase
GSH73_RS11995	COG0165	Argininosuccinate lyase
GSH73_RS12010	COG0505	Belongs to the CarA family
GSH73_RS12015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GSH73_RS12025	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GSH73_RS12030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GSH73_RS12065	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GSH73_RS12070	COG5434	Belongs to the glycosyl hydrolase 28 family
GSH73_RS12070	COG4632	Exopolysaccharide biosynthesis protein
GSH73_RS12085	COG0671	phosphoesterase, PA-phosphatase related
GSH73_RS12095	COG3859	Proton-coupled thiamine transporter YuaJ
GSH73_RS12100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GSH73_RS12125	COG0531	amino acid
GSH73_RS12135	COG2197	response regulator
GSH73_RS12155	COG1131	(ABC) transporter
GSH73_RS12160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GSH73_RS12165	COG0018	arginyl-trna synthetase
GSH73_RS12175	COG1181	Belongs to the D-alanine--D-alanine ligase family
GSH73_RS12180	COG1438	arginine binding
GSH73_RS12195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GSH73_RS12200	COG2235	arginine
GSH73_RS12205	COG0531	amino acid
GSH73_RS12210	COG1438	arginine binding
GSH73_RS12220	COG1609	Transcriptional regulator
GSH73_RS12225	COG0395	ABC-type sugar transport system, permease component
GSH73_RS12230	COG1175	transmembrane transport
GSH73_RS12245	COG2959	enzyme of heme biosynthesis
GSH73_RS12250	COG3773	Cell wall hydrolase
GSH73_RS12250	COG3409	Peptidoglycan-binding domain 1 protein
GSH73_RS12255	COG1982	Orn Lys Arg decarboxylase major
GSH73_RS12270	COG0531	amino acid
GSH73_RS12275	COG0697	spore germination
GSH73_RS12290	COG1802	Transcriptional regulator
GSH73_RS12305	COG4466	Protein conserved in bacteria
GSH73_RS12315	COG2002	toxin-antitoxin pair type II binding
GSH73_RS12320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GSH73_RS12325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GSH73_RS12340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSH73_RS12345	COG3850	Histidine kinase
GSH73_RS12345	COG5002	protein histidine kinase activity
GSH73_RS12355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GSH73_RS12360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GSH73_RS12370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GSH73_RS12375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GSH73_RS12380	COG1609	Transcriptional regulator
GSH73_RS12390	COG0071	Belongs to the small heat shock protein (HSP20) family
GSH73_RS12400	COG1664	Polymer-forming cytoskeletal
GSH73_RS12405	COG0789	Transcriptional regulator
GSH73_RS12430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSH73_RS12510	COG2221	Nitrite and sulphite reductase 4Fe-4S
GSH73_RS12520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GSH73_RS12550	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GSH73_RS12555	COG3833	ABC-type maltose transport systems, permease component
GSH73_RS12560	COG1175	transmembrane transport
GSH73_RS12580	COG0513	Belongs to the DEAD box helicase family
GSH73_RS12590	COG3773	Cell wall hydrolase
GSH73_RS12590	COG3409	Peptidoglycan-binding domain 1 protein
GSH73_RS12595	COG0309	Hydrogenase expression formation protein (HypE)
GSH73_RS12605	COG0298	carbon dioxide binding
GSH73_RS12610	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GSH73_RS12620	COG0375	protein maturation
GSH73_RS12625	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSH73_RS12640	COG3260	NADH ubiquinone oxidoreductase 20
GSH73_RS12650	COG2111	Na H antiporter
GSH73_RS12650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GSH73_RS12670	COG0489	protein tyrosine kinase activity
GSH73_RS12685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GSH73_RS12690	COG3583	domain protein
GSH73_RS12690	COG3584	3D domain protein
GSH73_RS12700	COG0084	hydrolase, TatD family'
GSH73_RS12755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSH73_RS12755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSH73_RS12765	COG0700	Nucleoside recognition
GSH73_RS12770	COG2715	membrane protein required for spore maturation
GSH73_RS12775	COG2002	toxin-antitoxin pair type II binding
GSH73_RS12780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GSH73_RS12785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GSH73_RS12790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GSH73_RS12795	COG2235	arginine
GSH73_RS12805	COG0730	response to heat
GSH73_RS12815	COG1774	PSP1 C-terminal conserved region
GSH73_RS12820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GSH73_RS12830	COG3870	Protein conserved in bacteria
GSH73_RS12835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GSH73_RS12840	COG1982	Orn Lys Arg decarboxylase major
GSH73_RS12850	COG0519	Catalyzes the synthesis of GMP from XMP
GSH73_RS12855	COG1940	carbohydrate kinase activity
GSH73_RS12875	COG1573	uracil-dna glycosylase
GSH73_RS12885	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GSH73_RS12890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSH73_RS12895	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GSH73_RS12900	COG1882	Formate acetyltransferase
GSH73_RS12905	COG1187	pseudouridine synthase activity
GSH73_RS12920	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GSH73_RS12925	COG1028	Short-chain dehydrogenase reductase Sdr
GSH73_RS12980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GSH73_RS12990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GSH73_RS12995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GSH73_RS13000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GSH73_RS13005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GSH73_RS13010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GSH73_RS13010	COG2199	diguanylate cyclase activity
GSH73_RS13030	COG0590	tRNA wobble adenosine to inosine editing
GSH73_RS13100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSH73_RS13105	COG3547	Transposase (IS116 IS110 IS902 family)
GSH73_RS13110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GSH73_RS13120	COG0438	transferase activity, transferring glycosyl groups
GSH73_RS13130	COG0438	transferase activity, transferring glycosyl groups
GSH73_RS13135	COG1215	transferase activity, transferring glycosyl groups
GSH73_RS13185	COG1203	CRISPR-associated helicase, Cas3
GSH73_RS13205	COG1615	UPF0182 protein
GSH73_RS13225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GSH73_RS13230	COG0681	Belongs to the peptidase S26 family
GSH73_RS13260	COG0028	Belongs to the TPP enzyme family
GSH73_RS13265	COG0129	dihydroxy-acid dehydratase activity
GSH73_RS13270	COG0473	3-isopropylmalate dehydrogenase activity
GSH73_RS13275	COG0066	3-isopropylmalate dehydratase activity
GSH73_RS13285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GSH73_RS13290	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GSH73_RS13295	COG0440	acetolactate synthase activity
GSH73_RS13310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GSH73_RS13315	COG0187	DNA topoisomerase II activity
GSH73_RS13325	COG3442	glutamine amidotransferase
GSH73_RS13345	COG0592	DNA-directed DNA polymerase activity