locus-tag	class	description
TTHE_RS00015	COG0592	DNA-directed DNA polymerase activity
TTHE_RS00020	COG2501	S4 domain
TTHE_RS00045	COG0187	DNA topoisomerase II activity
TTHE_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TTHE_RS00065	COG0440	acetolactate synthase activity
TTHE_RS00070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TTHE_RS00075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TTHE_RS00080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TTHE_RS00085	COG0066	3-isopropylmalate dehydratase activity
TTHE_RS00090	COG0473	3-isopropylmalate dehydrogenase activity
TTHE_RS00095	COG0129	dihydroxy-acid dehydratase activity
TTHE_RS00100	COG0028	Belongs to the TPP enzyme family
TTHE_RS00150	COG1316	TRANSCRIPTIONal
TTHE_RS00155	COG1615	UPF0182 protein
TTHE_RS00235	COG0590	tRNA wobble adenosine to inosine editing
TTHE_RS00260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TTHE_RS00260	COG2199	diguanylate cyclase activity
TTHE_RS00265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TTHE_RS00275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TTHE_RS00285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TTHE_RS00295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TTHE_RS00345	COG1028	Short-chain dehydrogenase reductase Sdr
TTHE_RS00350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TTHE_RS00365	COG1187	pseudouridine synthase activity
TTHE_RS00375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TTHE_RS00380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTHE_RS00385	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TTHE_RS00395	COG1573	uracil-dna glycosylase
TTHE_RS00410	COG1940	carbohydrate kinase activity
TTHE_RS00415	COG0519	Catalyzes the synthesis of GMP from XMP
TTHE_RS00425	COG1982	Orn Lys Arg decarboxylase major
TTHE_RS00435	COG3870	Protein conserved in bacteria
TTHE_RS00450	COG1774	PSP1 C-terminal conserved region
TTHE_RS00460	COG0730	response to heat
TTHE_RS00475	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TTHE_RS00480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TTHE_RS00485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TTHE_RS00490	COG2002	toxin-antitoxin pair type II binding
TTHE_RS00495	COG2715	membrane protein required for spore maturation
TTHE_RS00500	COG0700	Nucleoside recognition
TTHE_RS00505	COG0617	tRNA 3'-terminal CCA addition
TTHE_RS00510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTHE_RS00510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTHE_RS00515	COG1725	Transcriptional regulator
TTHE_RS00520	COG1131	(ABC) transporter
TTHE_RS00560	COG3063	Type IV pilus biogenesis stability protein PilW
TTHE_RS00575	COG0084	hydrolase, TatD family'
TTHE_RS00585	COG3583	domain protein
TTHE_RS00585	COG3584	3D domain protein
TTHE_RS00590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TTHE_RS00610	COG0489	protein tyrosine kinase activity
TTHE_RS00630	COG2111	Na H antiporter
TTHE_RS00630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TTHE_RS00640	COG3260	NADH ubiquinone oxidoreductase 20
TTHE_RS00655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHE_RS00660	COG0375	protein maturation
TTHE_RS00670	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TTHE_RS00675	COG0298	carbon dioxide binding
TTHE_RS00680	COG0409	Hydrogenase expression formation protein
TTHE_RS00685	COG0309	Hydrogenase expression formation protein (HypE)
TTHE_RS00690	COG3773	Cell wall hydrolase
TTHE_RS00690	COG3409	Peptidoglycan-binding domain 1 protein
TTHE_RS00720	COG1175	transmembrane transport
TTHE_RS00725	COG3833	ABC-type maltose transport systems, permease component
TTHE_RS00730	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TTHE_RS00750	COG1131	(ABC) transporter
TTHE_RS00760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TTHE_RS00880	COG0789	Transcriptional regulator
TTHE_RS00885	COG1664	Polymer-forming cytoskeletal
TTHE_RS00895	COG0071	Belongs to the small heat shock protein (HSP20) family
TTHE_RS00930	COG0071	Belongs to the small heat shock protein (HSP20) family
TTHE_RS00940	COG1609	Transcriptional regulator
TTHE_RS00945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TTHE_RS00950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TTHE_RS00960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TTHE_RS00965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TTHE_RS00975	COG3850	Histidine kinase
TTHE_RS00975	COG5002	protein histidine kinase activity
TTHE_RS00980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TTHE_RS00995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TTHE_RS01000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TTHE_RS01005	COG2002	toxin-antitoxin pair type II binding
TTHE_RS01015	COG4466	Protein conserved in bacteria
TTHE_RS01025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TTHE_RS01030	COG1802	Transcriptional regulator
TTHE_RS01045	COG0697	spore germination
TTHE_RS01050	COG0531	amino acid
TTHE_RS01065	COG1982	Orn Lys Arg decarboxylase major
TTHE_RS01075	COG2959	enzyme of heme biosynthesis
TTHE_RS01095	COG0018	arginyl-trna synthetase
TTHE_RS01100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TTHE_RS01105	COG1131	(ABC) transporter
TTHE_RS01115	COG0531	amino acid
TTHE_RS01125	COG0667	Aldo Keto reductase
TTHE_RS01135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TTHE_RS01140	COG3859	Proton-coupled thiamine transporter YuaJ
TTHE_RS01150	COG0671	phosphoesterase, PA-phosphatase related
TTHE_RS01165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TTHE_RS01190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TTHE_RS01195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TTHE_RS01205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TTHE_RS01210	COG0505	Belongs to the CarA family
TTHE_RS01235	COG0446	pyridine nucleotide-disulphide oxidoreductase
TTHE_RS01240	COG0586	Pfam SNARE associated Golgi protein
TTHE_RS01260	COG2033	superoxide reductase activity
TTHE_RS01265	COG1027	Aspartate ammonia-lyase
TTHE_RS01270	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TTHE_RS01275	COG2211	Major facilitator Superfamily
TTHE_RS01285	COG3956	TIGRFAM MazG family protein
TTHE_RS01290	COG0776	regulation of translation
TTHE_RS01295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TTHE_RS01300	COG2385	sporulation resulting in formation of a cellular spore
TTHE_RS01330	COG1098	S1 RNA binding domain
TTHE_RS01335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TTHE_RS01335	COG0248	Ppx GppA phosphatase
TTHE_RS01360	COG1396	sequence-specific DNA binding
TTHE_RS01395	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
TTHE_RS01500	COG0739	heme binding
TTHE_RS01590	COG0840	transmembrane signaling receptor activity
TTHE_RS01625	COG0653	protein targeting
TTHE_RS01640	COG0860	N-Acetylmuramoyl-L-alanine amidase
TTHE_RS01650	COG2233	PERMEase
TTHE_RS01665	COG1131	(ABC) transporter
TTHE_RS01675	COG1309	transcriptional regulator
TTHE_RS01680	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TTHE_RS01680	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTHE_RS01680	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTHE_RS01680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TTHE_RS01705	COG1131	(ABC) transporter
TTHE_RS01715	COG1595	DNA-templated transcription, initiation
TTHE_RS01735	COG3830	Belongs to the UPF0237 family
TTHE_RS01745	COG2226	methyltransferase
TTHE_RS01770	COG2208	phosphoserine phosphatase activity
TTHE_RS01785	COG0037	tRNA processing
TTHE_RS01790	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TTHE_RS01810	COG5002	protein histidine kinase activity
TTHE_RS01825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TTHE_RS01830	COG4770	biotin carboxylase activity
TTHE_RS01835	COG4684	Psort location CytoplasmicMembrane, score
TTHE_RS01850	COG0697	spore germination
TTHE_RS01875	COG5322	oxidoreductase activity
TTHE_RS01875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TTHE_RS01885	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TTHE_RS01895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TTHE_RS01900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TTHE_RS01905	COG0720	synthase
TTHE_RS01915	COG4224	UPF0291 protein
TTHE_RS01935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TTHE_RS01945	COG2203	Gaf domain
TTHE_RS01945	COG2199	diguanylate cyclase activity
TTHE_RS01950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TTHE_RS01955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TTHE_RS01960	COG0281	malic enzyme
TTHE_RS01975	COG3880	PFAM UvrB UvrC protein
TTHE_RS01980	COG3869	Catalyzes the specific phosphorylation of arginine residues in
TTHE_RS01985	COG0542	response to heat
TTHE_RS01990	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TTHE_RS02000	COG4956	integral membrane protein (PIN domain superfamily)
TTHE_RS02005	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TTHE_RS02015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TTHE_RS02030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TTHE_RS02035	COG1045	serine acetyltransferase
TTHE_RS02050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TTHE_RS02055	COG3688	RNA-binding protein containing a PIN domain
TTHE_RS02060	COG1595	DNA-templated transcription, initiation
TTHE_RS02070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TTHE_RS02075	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TTHE_RS02080	COG0250	Participates in transcription elongation, termination and antitermination
TTHE_RS02100	COG0222	ribosome binding
TTHE_RS02105	COG0085	RNA polymerase activity
TTHE_RS02110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TTHE_RS02115	COG1358	cellular component organization or biogenesis
TTHE_RS02120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TTHE_RS02125	COG0049	tRNA binding
TTHE_RS02135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TTHE_RS02145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TTHE_RS02170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TTHE_RS02175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TTHE_RS02180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TTHE_RS02210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TTHE_RS02220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TTHE_RS02235	COG1841	ribosomal large subunit assembly
TTHE_RS02245	COG0201	protein transport
TTHE_RS02265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TTHE_RS02270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TTHE_RS02280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TTHE_RS02305	COG1122	ATPase activity
TTHE_RS02310	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TTHE_RS02320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TTHE_RS02390	COG1136	(ABC) transporter
TTHE_RS02395	COG1136	(ABC) transporter
TTHE_RS02395	COG0577	efflux transmembrane transporter activity
TTHE_RS02400	COG1454	alcohol dehydrogenase
TTHE_RS02450	COG0714	Associated with various cellular activities
TTHE_RS02455	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
TTHE_RS02460	COG1305	Transglutaminase-like
TTHE_RS02470	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TTHE_RS02510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TTHE_RS02520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TTHE_RS02565	COG1397	ADP-ribosylglycohydrolase
TTHE_RS02575	COG1396	sequence-specific DNA binding
TTHE_RS02665	COG0454	-acetyltransferase
TTHE_RS02675	COG0561	phosphatase activity
TTHE_RS02680	COG2703	oxygen carrier activity
TTHE_RS02690	COG3973	AAA domain
TTHE_RS02695	COG0432	Pfam Uncharacterised protein family UPF0047
TTHE_RS02710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TTHE_RS02710	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TTHE_RS02720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TTHE_RS02730	COG2337	Toxic component of a toxin-antitoxin (TA) module
TTHE_RS02750	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
TTHE_RS02765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TTHE_RS02770	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TTHE_RS02780	COG1773	rubredoxin
TTHE_RS02785	COG0673	inositol 2-dehydrogenase activity
TTHE_RS02800	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TTHE_RS02800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TTHE_RS02805	COG3459	Glycosyltransferase 36 associated
TTHE_RS02810	COG1725	Transcriptional regulator
TTHE_RS02820	COG4377	Putative membrane peptidase family (DUF2324)
TTHE_RS02825	COG0330	HflC and HflK could
TTHE_RS02835	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TTHE_RS02845	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TTHE_RS02855	COG0131	Imidazoleglycerol-phosphate dehydratase
TTHE_RS02860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TTHE_RS02875	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TTHE_RS02875	COG0140	phosphoribosyl-ATP diphosphatase activity
TTHE_RS02880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TTHE_RS02895	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
TTHE_RS02905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TTHE_RS02930	COG0640	Transcriptional regulator
TTHE_RS02945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TTHE_RS02950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TTHE_RS02955	COG0640	Transcriptional regulator
TTHE_RS02965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TTHE_RS02970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TTHE_RS02975	COG0579	oxidoreductase
TTHE_RS02980	COG0492	ferredoxin-NADP+ reductase activity
TTHE_RS02990	COG3829	transcription factor binding
TTHE_RS02990	COG3290	protein histidine kinase activity
TTHE_RS02995	COG2376	Dihydroxyacetone kinase
TTHE_RS03005	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
TTHE_RS03050	COG0849	cell division
TTHE_RS03075	COG1131	(ABC) transporter
TTHE_RS03105	COG3842	ATPase activity
TTHE_RS03115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TTHE_RS03120	COG0437	4 iron, 4 sulfur cluster binding
TTHE_RS03125	COG0069	glutamate synthase activity
TTHE_RS03130	COG0067	glutamate synthase
TTHE_RS03135	COG3835	regulator
TTHE_RS03140	COG2884	Cell division ATP-binding protein ftsE
TTHE_RS03145	COG2177	Part of the ABC transporter FtsEX involved in
TTHE_RS03150	COG0739	heme binding
TTHE_RS03155	COG0793	Belongs to the peptidase S41A family
TTHE_RS03165	COG2045	Belongs to the ComB family
TTHE_RS03170	COG0556	nucleotide-excision repair
TTHE_RS03180	COG1716	ATPase activity
TTHE_RS03190	COG0768	penicillin binding
TTHE_RS03200	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TTHE_RS03200	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TTHE_RS03205	COG3711	transcriptional antiterminator
TTHE_RS03210	COG1263	PTS System
TTHE_RS03210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TTHE_RS03210	COG2190	(PTS) system
TTHE_RS03235	COG0318	PFAM AMP-dependent synthetase and ligase
TTHE_RS03245	COG0673	inositol 2-dehydrogenase activity
TTHE_RS03260	COG0673	inositol 2-dehydrogenase activity
TTHE_RS03265	COG3250	beta-galactosidase activity
TTHE_RS03270	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TTHE_RS03270	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TTHE_RS03275	COG1447	Phosphotransferase system cellobiose-specific component IIA
TTHE_RS03280	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TTHE_RS03290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TTHE_RS03300	COG2723	6-phospho-beta-galactosidase activity
TTHE_RS03305	COG1874	Beta-galactosidase
TTHE_RS03310	COG1501	Belongs to the glycosyl hydrolase 31 family
TTHE_RS03315	COG3534	alpha-L-arabinofuranosidase
TTHE_RS03325	COG4209	transmembrane transport
TTHE_RS03330	COG0395	ABC-type sugar transport system, permease component
TTHE_RS03360	COG3507	Belongs to the glycosyl hydrolase 43 family
TTHE_RS03365	COG2160	L-arabinose isomerase activity
TTHE_RS03370	COG1069	ribulokinase activity
TTHE_RS03375	COG0235	Class ii aldolase
TTHE_RS03385	COG1609	Transcriptional regulator
TTHE_RS03390	COG0371	Dehydrogenase
TTHE_RS03415	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
TTHE_RS03420	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TTHE_RS03425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TTHE_RS03430	COG1940	carbohydrate kinase activity
TTHE_RS03435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TTHE_RS03445	COG3547	Transposase (IS116 IS110 IS902 family)
TTHE_RS03495	COG0657	acetylesterase activity
TTHE_RS03500	COG1472	Belongs to the glycosyl hydrolase 3 family
TTHE_RS03525	COG1477	protein flavinylation
TTHE_RS03535	COG0768	penicillin binding
TTHE_RS03540	COG1793	dna ligase
TTHE_RS03540	COG3285	dna ligase
TTHE_RS03545	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TTHE_RS03550	COG0791	NLP P60 protein
TTHE_RS03550	COG1388	LysM domain
TTHE_RS03555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TTHE_RS03570	COG2755	lipolytic protein G-D-S-L family
TTHE_RS03570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TTHE_RS03575	COG0531	amino acid
TTHE_RS03580	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TTHE_RS03600	COG2608	mercury ion transmembrane transporter activity
TTHE_RS03610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TTHE_RS03615	COG1193	negative regulation of DNA recombination
TTHE_RS03620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TTHE_RS03620	COG1796	DNA polymerase
TTHE_RS03625	COG2226	methyltransferase
TTHE_RS03630	COG0626	cystathionine gamma-synthase activity
TTHE_RS03635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TTHE_RS03640	COG2873	o-acetylhomoserine
TTHE_RS03650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TTHE_RS03655	COG4942	peptidase
TTHE_RS03675	COG1914	H( )-stimulated, divalent metal cation uptake system
TTHE_RS03685	COG2226	methyltransferase
TTHE_RS03695	COG0785	Cytochrome C biogenesis protein
TTHE_RS03715	COG5002	protein histidine kinase activity
TTHE_RS03720	COG2204	response regulator
TTHE_RS03735	COG2217	Heavy metal translocating P-type atpase
TTHE_RS03740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TTHE_RS03745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TTHE_RS03750	COG1660	Displays ATPase and GTPase activities
TTHE_RS03770	COG1653	transport
TTHE_RS03790	COG1175	transmembrane transport
TTHE_RS03795	COG3833	ABC-type maltose transport systems, permease component
TTHE_RS03810	COG1426	Protein conserved in bacteria
TTHE_RS03815	COG0366	Alpha amylase catalytic
TTHE_RS03825	COG1481	regulation of sporulation
TTHE_RS03830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TTHE_RS03835	COG4109	DRTGG domain
TTHE_RS03870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TTHE_RS03900	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TTHE_RS03955	COG4695	Portal protein
TTHE_RS03960	COG0740	serine-type endopeptidase activity
TTHE_RS04065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TTHE_RS04080	COG2217	Heavy metal translocating P-type atpase
TTHE_RS04090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TTHE_RS04115	COG0778	Nitroreductase
TTHE_RS04140	COG1199	ATP-dependent helicase activity
TTHE_RS04150	COG1073	alpha beta
TTHE_RS04150	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
TTHE_RS04150	COG3064	Membrane
TTHE_RS04155	COG2195	Cleaves the N-terminal amino acid of tripeptides
TTHE_RS04160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TTHE_RS04165	COG0778	Nitroreductase
TTHE_RS04190	COG4656	Part of a membrane complex involved in electron transport
TTHE_RS04195	COG4658	electron transport chain
TTHE_RS04200	COG4659	FMN binding
TTHE_RS04205	COG4660	Part of a membrane complex involved in electron transport
TTHE_RS04210	COG4657	Part of a membrane complex involved in electron transport
TTHE_RS04215	COG2878	Part of a membrane complex involved in electron transport
TTHE_RS04215	COG1245	4Fe-4S binding domain
TTHE_RS04230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TTHE_RS04230	COG0646	methionine synthase
TTHE_RS04235	COG0646	methionine synthase
TTHE_RS04235	COG1410	methionine synthase
TTHE_RS04240	COG3546	catalase activity
TTHE_RS04255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TTHE_RS04270	COG0745	RESPONSE REGULATOR receiver
TTHE_RS04275	COG5002	protein histidine kinase activity
TTHE_RS04320	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TTHE_RS04335	COG0667	Aldo Keto reductase
TTHE_RS04355	COG0789	Transcriptional regulator
TTHE_RS04375	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TTHE_RS04380	COG1234	tRNA 3'-trailer cleavage
TTHE_RS04395	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TTHE_RS04405	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TTHE_RS04415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TTHE_RS04420	COG0569	domain protein
TTHE_RS04425	COG0356	it plays a direct role in the translocation of protons across the membrane
TTHE_RS04430	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TTHE_RS04435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TTHE_RS04440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TTHE_RS04445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TTHE_RS04450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TTHE_RS04455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TTHE_RS04460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TTHE_RS04475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TTHE_RS04475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TTHE_RS04480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TTHE_RS04485	COG1116	anion transmembrane transporter activity
TTHE_RS04490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TTHE_RS04500	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TTHE_RS04560	COG0438	transferase activity, transferring glycosyl groups
TTHE_RS04585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TTHE_RS04590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TTHE_RS04605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TTHE_RS04710	COG1201	RNA secondary structure unwinding
TTHE_RS04805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TTHE_RS04820	COG1802	Transcriptional regulator
TTHE_RS04825	COG1312	Catalyzes the dehydration of D-mannonate
TTHE_RS04830	COG4209	transmembrane transport
TTHE_RS04835	COG0395	ABC-type sugar transport system, permease component
TTHE_RS04850	COG0673	inositol 2-dehydrogenase activity
TTHE_RS04865	COG3664	PFAM glycoside hydrolase family 39
TTHE_RS04870	COG3458	cephalosporin-C deacetylase activity
TTHE_RS04880	COG3275	phosphorelay sensor kinase activity
TTHE_RS04900	COG4209	transmembrane transport
TTHE_RS04905	COG0395	ABC-type sugar transport system, permease component
TTHE_RS04925	COG1653	transport
TTHE_RS04930	COG1175	transmembrane transport
TTHE_RS04935	COG0395	ABC-type sugar transport system, permease component
TTHE_RS05005	COG1942	4-Oxalocrotonate Tautomerase
TTHE_RS05045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TTHE_RS05055	COG1316	TRANSCRIPTIONal
TTHE_RS05060	COG3949	Membrane
TTHE_RS05070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TTHE_RS05085	COG2814	Major facilitator Superfamily
TTHE_RS05100	COG0426	domain, Protein
TTHE_RS05105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TTHE_RS05110	COG0671	phosphoesterase, PA-phosphatase related
TTHE_RS05120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TTHE_RS05125	COG1606	tRNA processing
TTHE_RS05130	COG1691	(AIR) carboxylase
TTHE_RS05135	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TTHE_RS05140	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TTHE_RS05145	COG1268	BioY protein
TTHE_RS05150	COG0525	valine-tRNA ligase activity
TTHE_RS05160	COG0285	dihydrofolate synthase activity
TTHE_RS05195	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TTHE_RS05225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TTHE_RS05250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TTHE_RS05260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TTHE_RS05285	COG1181	Belongs to the D-alanine--D-alanine ligase family
TTHE_RS05295	COG1252	NADH dehydrogenase
TTHE_RS05310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TTHE_RS05315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TTHE_RS05330	COG3858	chitin binding
TTHE_RS05340	COG0739	heme binding
TTHE_RS05345	COG0438	transferase activity, transferring glycosyl groups
TTHE_RS05390	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TTHE_RS05395	COG4475	Protein of unknown function (DUF436)
TTHE_RS05405	COG2217	Heavy metal translocating P-type atpase
TTHE_RS05410	COG2217	Heavy metal translocating P-type atpase
TTHE_RS05420	COG1388	LysM domain
TTHE_RS05420	COG3858	chitin binding
TTHE_RS05425	COG1983	PspC domain protein
TTHE_RS05430	COG1113	amino acid transport
TTHE_RS05440	COG1376	ErfK ybiS ycfS ynhG family protein
TTHE_RS05445	COG1595	DNA-templated transcription, initiation
TTHE_RS05460	COG0237	dephospho-CoA kinase activity
TTHE_RS05465	COG0741	lytic transglycosylase activity
TTHE_RS05470	COG2707	UPF0756 membrane protein
TTHE_RS05490	COG0791	NLP P60 protein
TTHE_RS05495	COG1217	gtp-binding protein TYPA
TTHE_RS05500	COG0741	lytic transglycosylase activity
TTHE_RS05515	COG2172	sigma factor antagonist activity
TTHE_RS05520	COG2878	Part of a membrane complex involved in electron transport
TTHE_RS05540	COG3290	protein histidine kinase activity
TTHE_RS05570	COG2003	Belongs to the UPF0758 family
TTHE_RS05575	COG1077	Cell shape determining protein MreB Mrl
TTHE_RS05600	COG2894	cell division
TTHE_RS05610	COG0772	Belongs to the SEDS family
TTHE_RS05620	COG1388	LysM domain
TTHE_RS05620	COG0739	heme binding
TTHE_RS05625	COG1994	Peptidase M50
TTHE_RS05625	COG0517	IMP dehydrogenase activity
TTHE_RS05640	COG1530	ribonuclease E activity
TTHE_RS05675	COG1713	HD superfamily hydrolase involved in NAD metabolism
TTHE_RS05680	COG0799	negative regulation of ribosome biogenesis
TTHE_RS05685	COG2964	Protein conserved in bacteria
TTHE_RS05690	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
TTHE_RS05695	COG1686	Belongs to the peptidase S11 family
TTHE_RS05700	COG1596	polysaccharide export
TTHE_RS05700	COG1555	photosystem II stabilization
TTHE_RS05710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TTHE_RS05715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TTHE_RS05720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TTHE_RS05745	COG0493	'glutamate synthase
TTHE_RS05765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TTHE_RS05770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TTHE_RS05795	COG1131	(ABC) transporter
TTHE_RS05800	COG1846	Transcriptional regulator
TTHE_RS05815	COG1234	tRNA 3'-trailer cleavage
TTHE_RS05820	COG0658	competence protein
TTHE_RS05820	COG2333	competence protein COMEC
TTHE_RS05830	COG0268	Binds directly to 16S ribosomal RNA
TTHE_RS05840	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TTHE_RS05870	COG0481	GTPase activity
TTHE_RS05875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TTHE_RS05885	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TTHE_RS05895	COG0443	Heat shock 70 kDa protein
TTHE_RS05900	COG0484	heat shock protein binding
TTHE_RS05905	COG2264	protein methyltransferase activity
TTHE_RS05910	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TTHE_RS05915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTHE_RS05920	COG0537	adenosine 5'-monophosphoramidase activity
TTHE_RS05930	COG1610	YqeY-like protein
TTHE_RS05945	COG1702	phosphate starvation-inducible protein PhoH
TTHE_RS05950	COG1480	7TM receptor with intracellular HD hydrolase
TTHE_RS05960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TTHE_RS05985	COG0423	glycine-tRNA ligase activity
TTHE_RS05995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TTHE_RS05995	COG0574	Belongs to the PEP-utilizing enzyme family
TTHE_RS06015	COG0557	exoribonuclease II activity
TTHE_RS06055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TTHE_RS06070	COG2302	S4 RNA-binding domain
TTHE_RS06075	COG3599	regulation of cell shape
TTHE_RS06090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TTHE_RS06105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TTHE_RS06105	COG0512	Glutamine amidotransferase of anthranilate synthase
TTHE_RS06120	COG0135	phosphoribosylanthranilate isomerase activity
TTHE_RS06135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TTHE_RS06175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TTHE_RS06185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TTHE_RS06190	COG0564	pseudouridine synthase activity
TTHE_RS06205	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TTHE_RS06210	COG1937	Protein conserved in bacteria
TTHE_RS06215	COG3118	belongs to the thioredoxin family
TTHE_RS06225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TTHE_RS06230	COG1959	2 iron, 2 sulfur cluster binding
TTHE_RS06260	COG0628	permease
TTHE_RS06270	COG4472	Bacterial protein of unknown function (DUF965)
TTHE_RS06280	COG3906	Belongs to the UPF0473 family
TTHE_RS06285	COG0735	belongs to the Fur family
TTHE_RS06290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TTHE_RS06295	COG3679	Belongs to the UPF0342 family
TTHE_RS06300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TTHE_RS06305	COG4122	O-methyltransferase activity
TTHE_RS06310	COG0826	peptidase U32
TTHE_RS06315	COG0768	penicillin binding
TTHE_RS06325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TTHE_RS06330	COG0546	phosphoglycolate phosphatase activity
TTHE_RS06335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TTHE_RS06340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TTHE_RS06350	COG1459	type II secretion system
TTHE_RS06360	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TTHE_RS06415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TTHE_RS06425	COG0006	proline dipeptidase activity
TTHE_RS06440	COG3854	ATPases associated with a variety of cellular activities
TTHE_RS06480	COG1302	Protein conserved in bacteria
TTHE_RS06500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TTHE_RS06505	COG1570	exodeoxyribonuclease VII activity
TTHE_RS06515	COG0142	geranyltranstransferase activity
TTHE_RS06525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TTHE_RS06530	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TTHE_RS06540	COG1438	arginine binding
TTHE_RS06545	COG0497	DNA recombination
TTHE_RS06550	COG0750	zinc metalloprotease
TTHE_RS06585	COG0494	nUDIX hydrolase
TTHE_RS06590	COG1379	DNA repair
TTHE_RS06595	COG1300	Membrane
TTHE_RS06600	COG4974	Belongs to the 'phage' integrase family
TTHE_RS06605	COG1686	Belongs to the peptidase S11 family
TTHE_RS06610	COG1366	Belongs to the anti-sigma-factor antagonist family
TTHE_RS06625	COG3360	Dodecin
TTHE_RS06645	COG0617	tRNA 3'-terminal CCA addition
TTHE_RS06645	COG3620	sequence-specific DNA binding
TTHE_RS06645	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TTHE_RS06650	COG1994	Peptidase M50
TTHE_RS06660	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TTHE_RS06670	COG3874	Sporulation protein YtfJ
TTHE_RS06675	COG1686	Belongs to the peptidase S11 family
TTHE_RS06685	COG0445	tRNA wobble uridine modification
TTHE_RS06690	COG1187	pseudouridine synthase activity
TTHE_RS06700	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TTHE_RS06705	COG0010	Belongs to the arginase family
TTHE_RS06715	COG1388	LysM domain
TTHE_RS06735	COG0406	alpha-ribazole phosphatase activity
TTHE_RS06740	COG2081	HI0933 family
TTHE_RS06750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TTHE_RS06760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TTHE_RS06775	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TTHE_RS06790	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TTHE_RS06795	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TTHE_RS06810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TTHE_RS06815	COG0328	RNA-DNA hybrid ribonuclease activity
TTHE_RS06820	COG4974	Belongs to the 'phage' integrase family
TTHE_RS06825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TTHE_RS06830	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TTHE_RS06835	COG0464	growth
TTHE_RS06840	COG0017	Asparaginyl-tRNA synthetase
TTHE_RS06845	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TTHE_RS06855	COG0613	PHP domain protein
TTHE_RS06860	COG2359	stage V sporulation protein S
TTHE_RS06865	COG1692	metallophosphoesterase
TTHE_RS06870	COG1418	mRNA catabolic process
TTHE_RS06875	COG0419	ATPase involved in DNA repair
TTHE_RS06880	COG0420	3'-5' exonuclease activity
TTHE_RS06905	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TTHE_RS06910	COG1546	Belongs to the CinA family
TTHE_RS06910	COG1058	Belongs to the CinA family
TTHE_RS06915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TTHE_RS06920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTHE_RS06925	COG1674	ftsk spoiiie
TTHE_RS06935	COG0740	serine-type endopeptidase activity
TTHE_RS06940	COG0527	aspartate kinase activity
TTHE_RS06955	COG0612	Peptidase, M16
TTHE_RS06960	COG0726	polysaccharide deacetylase
TTHE_RS06965	COG1185	polyribonucleotide nucleotidyltransferase activity
TTHE_RS06970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TTHE_RS06975	COG0196	riboflavin kinase activity
TTHE_RS06980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TTHE_RS06985	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TTHE_RS06990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TTHE_RS07005	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TTHE_RS07010	COG0195	Participates in both transcription termination and antitermination
TTHE_RS07015	COG0779	Required for maturation of 30S ribosomal subunits
TTHE_RS07020	COG2176	DNA-directed DNA polymerase activity
TTHE_RS07030	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TTHE_RS07035	COG0750	zinc metalloprotease
TTHE_RS07040	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TTHE_RS07045	COG4589	Belongs to the CDS family
TTHE_RS07050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TTHE_RS07055	COG0233	cytoplasmic translational termination
TTHE_RS07060	COG0528	UMP kinase activity
TTHE_RS07065	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TTHE_RS07085	COG1191	sigma factor activity
TTHE_RS07090	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TTHE_RS07095	COG1776	CheC inhibitor of MCP methylation
TTHE_RS07105	COG0643	Histidine kinase
TTHE_RS07105	COG2198	Histidine kinase
TTHE_RS07115	COG0455	bacterial-type flagellum organization
TTHE_RS07125	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TTHE_RS07130	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TTHE_RS07135	COG1684	flagellar biosynthetic protein fliR
TTHE_RS07140	COG1987	bacterial-type flagellum assembly
TTHE_RS07145	COG1338	Plays a role in the flagellum-specific transport system
TTHE_RS07155	COG2201	protein-glutamate methylesterase activity
TTHE_RS07160	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TTHE_RS07160	COG1776	CheC inhibitor of MCP methylation
TTHE_RS07165	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TTHE_RS07170	COG1580	Controls the rotational direction of flagella during chemotaxis
TTHE_RS07175	COG1582	Flagellar protein (FlbD)
TTHE_RS07185	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TTHE_RS07205	COG1157	protein secretion by the type III secretion system
TTHE_RS07215	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TTHE_RS07220	COG1766	The M ring may be actively involved in energy transduction
TTHE_RS07225	COG1677	Flagellar hook-basal body complex protein FliE
TTHE_RS07235	COG1815	bacterial-type flagellum-dependent cell motility
TTHE_RS07245	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TTHE_RS07250	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TTHE_RS07255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TTHE_RS07260	COG0758	DNA mediated transformation
TTHE_RS07260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TTHE_RS07265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TTHE_RS07275	COG0180	Tryptophanyl-tRNA synthetase
TTHE_RS07280	COG0606	chelatase, subunit chli
TTHE_RS07295	COG0336	Belongs to the RNA methyltransferase TrmD family
TTHE_RS07305	COG1837	Belongs to the UPF0109 family
TTHE_RS07315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TTHE_RS07320	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
TTHE_RS07355	COG1136	(ABC) transporter
TTHE_RS07370	COG1595	DNA-templated transcription, initiation
TTHE_RS07375	COG0552	protein localization to endoplasmic reticulum
TTHE_RS07380	COG1196	nuclear chromosome segregation
TTHE_RS07385	COG2359	stage V sporulation protein S
TTHE_RS07395	COG0571	ribonuclease III activity
TTHE_RS07400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TTHE_RS07415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TTHE_RS07420	COG2070	2-Nitropropane dioxygenase
TTHE_RS07425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TTHE_RS07430	COG0416	fatty acid biosynthetic process
TTHE_RS07435	COG2030	dehydratase
TTHE_RS07440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TTHE_RS07445	COG1399	metal-binding, possibly nucleic acid-binding protein
TTHE_RS07450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TTHE_RS07455	COG0280	phosphate acetyltransferase
TTHE_RS07465	COG3314	Sporulation integral membrane protein YlbJ
TTHE_RS07475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TTHE_RS07480	COG0742	ribosomal rna small subunit methyltransferase
TTHE_RS07495	COG1307	EDD domain protein, DegV family
TTHE_RS07500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TTHE_RS07505	COG1461	Dihydroxyacetone kinase
TTHE_RS07510	COG1302	Protein conserved in bacteria
TTHE_RS07530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TTHE_RS07535	COG1162	GTPase activity
TTHE_RS07540	COG0515	serine threonine protein kinase
TTHE_RS07540	COG2815	serine threonine protein kinase
TTHE_RS07545	COG0631	protein serine/threonine phosphatase activity
TTHE_RS07555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TTHE_RS07555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TTHE_RS07560	COG2738	Putative neutral zinc metallopeptidase
TTHE_RS07570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TTHE_RS07580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TTHE_RS07585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TTHE_RS07595	COG0194	GDP metabolic process
TTHE_RS07605	COG1561	YicC-like family, N-terminal region
TTHE_RS07610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TTHE_RS07650	COG0167	dihydroorotate dehydrogenase activity
TTHE_RS07655	COG0543	2 iron, 2 sulfur cluster binding
TTHE_RS07670	COG0540	Belongs to the ATCase OTCase family
TTHE_RS07690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTHE_RS07700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TTHE_RS07705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TTHE_RS07710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TTHE_RS07710	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TTHE_RS07725	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TTHE_RS07730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TTHE_RS07755	COG0343	queuine tRNA-ribosyltransferase activity
TTHE_RS07760	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TTHE_RS07765	COG2385	sporulation resulting in formation of a cellular spore
TTHE_RS07785	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TTHE_RS07795	COG0835	chemotaxis
TTHE_RS07800	COG0217	transcriptional regulatory protein
TTHE_RS07805	COG0730	response to heat
TTHE_RS07825	COG1739	Uncharacterized protein family UPF0029
TTHE_RS07830	COG0494	nUDIX hydrolase
TTHE_RS07840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TTHE_RS07875	COG0175	sulfate reduction
TTHE_RS07880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TTHE_RS07895	COG0175	sulfate reduction
TTHE_RS07900	COG2873	o-acetylhomoserine
TTHE_RS07915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TTHE_RS07930	COG0113	porphobilinogen synthase activity
TTHE_RS07935	COG1648	precorrin-2 dehydrogenase activity
TTHE_RS07935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TTHE_RS07940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TTHE_RS07950	COG0181	hydroxymethylbilane synthase activity
TTHE_RS07955	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TTHE_RS07960	COG4172	Belongs to the ABC transporter superfamily
TTHE_RS07965	COG0444	Belongs to the ABC transporter superfamily
TTHE_RS07975	COG0601	transmembrane transport
TTHE_RS07980	COG4166	transmembrane transport
TTHE_RS07990	COG2078	PFAM AMMECR1 domain protein
TTHE_RS07990	COG3885	ferrous iron binding
TTHE_RS07995	COG0789	Transcriptional regulator
TTHE_RS08000	COG0477	Major facilitator Superfamily
TTHE_RS08005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TTHE_RS08010	COG1982	Orn Lys Arg decarboxylase major
TTHE_RS08020	COG2205	protein histidine kinase activity
TTHE_RS08025	COG0745	RESPONSE REGULATOR receiver
TTHE_RS08035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TTHE_RS08040	COG0785	Cytochrome C biogenesis protein
TTHE_RS08045	COG0363	glucosamine-6-phosphate deaminase activity
TTHE_RS08050	COG1940	carbohydrate kinase activity
TTHE_RS08075	COG2119	membrane
TTHE_RS08080	COG3773	Cell wall hydrolase
TTHE_RS08080	COG3409	Peptidoglycan-binding domain 1 protein
TTHE_RS08085	COG5002	protein histidine kinase activity
TTHE_RS08090	COG0745	RESPONSE REGULATOR receiver
TTHE_RS08100	COG0287	Prephenate dehydrogenase
TTHE_RS08105	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TTHE_RS08110	COG0077	Prephenate dehydratase
TTHE_RS08110	COG1605	Chorismate mutase
TTHE_RS08115	COG0318	PFAM AMP-dependent synthetase and ligase
TTHE_RS08120	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TTHE_RS08125	COG1760	l-serine dehydratase
TTHE_RS08135	COG1164	Oligoendopeptidase f
TTHE_RS08145	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TTHE_RS08150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TTHE_RS08160	COG0426	domain, Protein
TTHE_RS08165	COG3069	C4-dicarboxylate transmembrane transporter activity
TTHE_RS08180	COG1968	undecaprenyl-diphosphatase activity
TTHE_RS08185	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TTHE_RS08195	COG0584	glycerophosphoryl diester phosphodiesterase
TTHE_RS08200	COG1032	radical SAM domain protein
TTHE_RS08210	COG4086	secreted protein
TTHE_RS08215	COG3858	chitin binding
TTHE_RS08220	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TTHE_RS08225	COG0427	acetyl-CoA hydrolase
TTHE_RS08230	COG0183	Belongs to the thiolase family
TTHE_RS08235	COG1250	3-hydroxyacyl-CoA dehydrogenase
TTHE_RS08240	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TTHE_RS08245	COG2086	electron transfer activity
TTHE_RS08250	COG1960	acyl-CoA dehydrogenase activity
TTHE_RS08255	COG1024	Enoyl-CoA hydratase
TTHE_RS08260	COG3875	lactate racemase activity
TTHE_RS08265	COG0277	FAD linked oxidase domain protein
TTHE_RS08270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TTHE_RS08275	COG2086	electron transfer activity
TTHE_RS08280	COG1620	l-lactate permease
TTHE_RS08285	COG2186	Transcriptional regulator
TTHE_RS08290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TTHE_RS08305	COG0561	phosphatase activity
TTHE_RS08350	COG3964	amidohydrolase
TTHE_RS08355	COG3711	transcriptional antiterminator
TTHE_RS08380	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TTHE_RS08385	COG3457	Alanine racemase
TTHE_RS08390	COG0626	cystathionine gamma-synthase activity
TTHE_RS08395	COG1735	metal-dependent hydrolase with the TIM-barrel fold
TTHE_RS08420	COG2188	Transcriptional regulator
TTHE_RS08425	COG2313	pseudouridylate synthase activity
TTHE_RS08430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TTHE_RS08430	COG1522	sequence-specific DNA binding
TTHE_RS08435	COG1122	ATPase activity
TTHE_RS08530	COG1879	ABC-type sugar transport system periplasmic component
TTHE_RS08535	COG1172	Belongs to the binding-protein-dependent transport system permease family
TTHE_RS08540	COG1129	ABC transporter
TTHE_RS08545	COG1869	D-ribose catabolic process
TTHE_RS08550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TTHE_RS08555	COG1609	Transcriptional regulator
TTHE_RS08560	COG0191	fructose-bisphosphate aldolase activity
TTHE_RS08570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TTHE_RS08575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TTHE_RS08580	COG1063	alcohol dehydrogenase
TTHE_RS08600	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TTHE_RS08600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TTHE_RS08605	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TTHE_RS08605	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TTHE_RS08620	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TTHE_RS08665	COG0704	Plays a role in the regulation of phosphate uptake
TTHE_RS08670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TTHE_RS08675	COG0581	inorganic phosphate transmembrane transporter activity
TTHE_RS08680	COG0573	inorganic phosphate transmembrane transporter activity
TTHE_RS08685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TTHE_RS08690	COG5002	protein histidine kinase activity
TTHE_RS08695	COG0745	RESPONSE REGULATOR receiver
TTHE_RS08705	COG1873	PFAM PRC-barrel domain
TTHE_RS08710	COG1191	sigma factor activity
TTHE_RS08715	COG1191	sigma factor activity
TTHE_RS08725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TTHE_RS08730	COG0849	cell division
TTHE_RS08735	COG3856	small basic protein
TTHE_RS08745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TTHE_RS08750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TTHE_RS08760	COG0772	Belongs to the SEDS family
TTHE_RS08770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TTHE_RS08775	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TTHE_RS08780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TTHE_RS08785	COG0768	penicillin binding
TTHE_RS08805	COG0612	Peptidase, M16
TTHE_RS08810	COG0612	Peptidase, M16
TTHE_RS08820	COG0012	GTP binding
TTHE_RS08850	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TTHE_RS08860	COG1937	Protein conserved in bacteria
TTHE_RS08865	COG0438	transferase activity, transferring glycosyl groups
TTHE_RS08885	COG2340	Cysteine-rich secretory protein family
TTHE_RS08890	COG1362	aminopeptidase activity
TTHE_RS08895	COG2197	response regulator
TTHE_RS08920	COG1193	negative regulation of DNA recombination
TTHE_RS08925	COG0826	peptidase U32
TTHE_RS08935	COG0072	phenylalanine-tRNA ligase activity
TTHE_RS08935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTHE_RS08940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TTHE_RS08945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TTHE_RS08950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TTHE_RS08955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TTHE_RS08960	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TTHE_RS08965	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TTHE_RS08975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TTHE_RS08980	COG4399	Belongs to the UPF0754 family
TTHE_RS08995	COG0745	RESPONSE REGULATOR receiver
TTHE_RS09010	COG0367	asparagine synthase
TTHE_RS09015	COG0347	Belongs to the P(II) protein family
TTHE_RS09020	COG0004	ammonium transporteR
TTHE_RS09030	COG0004	ammonium transporteR
TTHE_RS09040	COG0371	Dehydrogenase
TTHE_RS09045	COG0390	transport system, permease component
TTHE_RS09050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TTHE_RS09065	COG0673	inositol 2-dehydrogenase activity
TTHE_RS09070	COG3716	PTS system mannose fructose sorbose family IID component
TTHE_RS09075	COG3715	PTS system
TTHE_RS09080	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TTHE_RS09080	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TTHE_RS09085	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TTHE_RS09085	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TTHE_RS09090	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TTHE_RS09090	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TTHE_RS09095	COG1122	ATPase activity
TTHE_RS09110	COG0310	cobalt ion transport
TTHE_RS09140	COG2242	protein methyltransferase activity
TTHE_RS09180	COG2814	Major facilitator Superfamily
TTHE_RS09220	COG0347	Belongs to the P(II) protein family
TTHE_RS09225	COG0347	Belongs to the P(II) protein family
TTHE_RS09245	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TTHE_RS09250	COG1433	Dinitrogenase iron-molybdenum cofactor
TTHE_RS09250	COG0535	radical SAM domain protein
TTHE_RS09255	COG0535	radical SAM domain protein
TTHE_RS09255	COG1433	Dinitrogenase iron-molybdenum cofactor
TTHE_RS09280	COG0352	thiamine-phosphate diphosphorylase activity
TTHE_RS09295	COG0351	phosphomethylpyrimidine kinase
TTHE_RS09295	COG0352	thiamine-phosphate diphosphorylase activity
TTHE_RS09310	COG1132	(ABC) transporter
TTHE_RS09320	COG0697	spore germination
TTHE_RS09325	COG5002	protein histidine kinase activity
TTHE_RS09345	COG1131	(ABC) transporter
TTHE_RS09355	COG1966	Carbon starvation protein
TTHE_RS09360	COG3279	Response regulator of the LytR AlgR family
TTHE_RS09365	COG3275	phosphorelay sensor kinase activity
TTHE_RS09400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TTHE_RS09430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TTHE_RS09435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TTHE_RS09440	COG0698	ribose 5-phosphate isomerase
TTHE_RS09445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TTHE_RS09455	COG3958	Transketolase
TTHE_RS09460	COG3959	Transketolase, thiamine diphosphate binding domain
TTHE_RS09475	COG3775	system Galactitol-specific IIC component
TTHE_RS09480	COG3414	Phosphotransferase system galactitol-specific IIB component
TTHE_RS09490	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TTHE_RS09490	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TTHE_RS09495	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TTHE_RS09515	COG1609	Transcriptional regulator
TTHE_RS09530	COG0366	Alpha amylase catalytic
TTHE_RS09535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TTHE_RS09540	COG0366	Alpha amylase catalytic
TTHE_RS09565	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TTHE_RS09570	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TTHE_RS09580	COG0395	ABC-type sugar transport system, permease component
TTHE_RS09585	COG1175	transmembrane transport
TTHE_RS09595	COG1609	Transcriptional regulator
TTHE_RS09605	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TTHE_RS09610	COG2942	2-epimerase
TTHE_RS09630	COG0346	lactoylglutathione lyase activity
TTHE_RS09645	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TTHE_RS09655	COG0569	domain protein
TTHE_RS09660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TTHE_RS09675	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TTHE_RS09685	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TTHE_RS09690	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TTHE_RS09695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TTHE_RS09705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TTHE_RS09715	COG5002	protein histidine kinase activity
TTHE_RS09720	COG0745	RESPONSE REGULATOR receiver
TTHE_RS09745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TTHE_RS09770	COG0726	polysaccharide deacetylase
TTHE_RS09780	COG5002	protein histidine kinase activity
TTHE_RS09785	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TTHE_RS09790	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TTHE_RS09795	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TTHE_RS09800	COG2205	protein histidine kinase activity
TTHE_RS09810	COG3850	Histidine kinase
TTHE_RS09810	COG5002	protein histidine kinase activity
TTHE_RS09815	COG0745	RESPONSE REGULATOR receiver
TTHE_RS09825	COG0367	asparagine synthase
TTHE_RS09830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TTHE_RS09840	COG0728	peptidoglycan biosynthetic process
TTHE_RS09850	COG1070	Carbohydrate kinase
TTHE_RS09860	COG0390	transport system, permease component
TTHE_RS09865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TTHE_RS09895	COG1278	Cold shock
TTHE_RS09900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TTHE_RS09915	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TTHE_RS09920	COG1902	pentaerythritol trinitrate reductase activity
TTHE_RS09930	COG1704	LemA family
TTHE_RS09935	COG1956	GAF domain-containing protein
TTHE_RS09980	COG1482	cell wall glycoprotein biosynthetic process
TTHE_RS09990	COG0482	sulfurtransferase activity
TTHE_RS09995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TTHE_RS10000	COG2384	SAM-dependent methyltransferase
TTHE_RS10015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TTHE_RS10020	COG0358	DNA primase activity
TTHE_RS10025	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TTHE_RS10030	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TTHE_RS10035	COG1342	Belongs to the UPF0251 family
TTHE_RS10040	COG0148	phosphopyruvate hydratase activity
TTHE_RS10045	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TTHE_RS10055	COG0126	phosphoglycerate kinase activity
TTHE_RS10070	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TTHE_RS10075	COG1254	Belongs to the acylphosphatase family
TTHE_RS10080	COG0561	phosphatase activity
TTHE_RS10085	COG0735	belongs to the Fur family
TTHE_RS10090	COG2720	vancomycin resistance protein
TTHE_RS10100	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TTHE_RS10105	COG1067	ATP-dependent peptidase activity
TTHE_RS10135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TTHE_RS10140	COG1773	rubredoxin
TTHE_RS10140	COG1592	Rubrerythrin
TTHE_RS10185	COG0564	pseudouridine synthase activity
TTHE_RS10195	COG2309	aminopeptidase activity
TTHE_RS10200	COG1074	ATP-dependent DNA helicase activity
TTHE_RS10210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TTHE_RS10215	COG1304	FMN binding
TTHE_RS10220	COG0778	Nitroreductase
TTHE_RS10230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TTHE_RS10240	COG3206	protein involved in exopolysaccharide biosynthesis
TTHE_RS10240	COG0489	protein tyrosine kinase activity
TTHE_RS10245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TTHE_RS10255	COG0457	Tetratricopeptide repeat
TTHE_RS10255	COG0463	Glycosyl transferase, family 2
TTHE_RS10265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TTHE_RS10275	COG0840	transmembrane signaling receptor activity
TTHE_RS10300	COG1752	Esterase of the alpha-beta hydrolase superfamily
TTHE_RS10310	COG1309	transcriptional regulator
TTHE_RS10355	COG0622	Phosphoesterase
TTHE_RS10370	COG0860	N-Acetylmuramoyl-L-alanine amidase
TTHE_RS10380	COG4608	Belongs to the ABC transporter superfamily
TTHE_RS10385	COG0444	Belongs to the ABC transporter superfamily
TTHE_RS10390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TTHE_RS10395	COG0601	transmembrane transport
TTHE_RS10400	COG4166	transmembrane transport
TTHE_RS10405	COG4166	transmembrane transport
TTHE_RS10410	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TTHE_RS10415	COG0154	amidase activity
TTHE_RS10425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TTHE_RS10435	COG4496	protein, YerC YecD
TTHE_RS10440	COG1447	Phosphotransferase system cellobiose-specific component IIA
TTHE_RS10445	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TTHE_RS10460	COG3711	transcriptional antiterminator
TTHE_RS10465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TTHE_RS10470	COG2011	ABC-type metal ion transport system permease component
TTHE_RS10480	COG2244	polysaccharide biosynthetic process
TTHE_RS10485	COG1854	S-ribosylhomocysteine lyase activity
TTHE_RS10500	COG1473	amidohydrolase
TTHE_RS10510	COG0151	Belongs to the GarS family
TTHE_RS10515	COG0138	bifunctional purine biosynthesis protein purh
TTHE_RS10520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TTHE_RS10525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TTHE_RS10530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TTHE_RS10535	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TTHE_RS10540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TTHE_RS10545	COG2252	PERMEase
TTHE_RS10550	COG2252	PERMEase
TTHE_RS10555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TTHE_RS10555	COG0519	Catalyzes the synthesis of GMP from XMP
TTHE_RS10560	COG0516	GMP reductase activity
TTHE_RS10560	COG0517	IMP dehydrogenase activity
TTHE_RS10595	COG1404	Belongs to the peptidase S8 family
TTHE_RS10605	COG3842	ATPase activity
TTHE_RS10610	COG4120	Belongs to the binding-protein-dependent transport system permease family
TTHE_RS10635	COG0411	ABC transporter
TTHE_RS10650	COG1132	(ABC) transporter
TTHE_RS10690	COG1811	Na channel or pump
TTHE_RS10715	COG1914	H( )-stimulated, divalent metal cation uptake system
TTHE_RS10725	COG1360	Flagellar Motor Protein
TTHE_RS10735	COG0488	(ABC) transporter
TTHE_RS10745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TTHE_RS10750	COG0456	acetyltransferase
TTHE_RS10755	COG1214	PFAM Peptidase M22, glycoprotease
TTHE_RS10760	COG0802	atpase or kinase
TTHE_RS10775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TTHE_RS10785	COG0398	Pfam SNARE associated Golgi protein
TTHE_RS10790	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TTHE_RS10795	COG2183	response to ionizing radiation
TTHE_RS10800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TTHE_RS10805	COG0653	protein targeting
TTHE_RS10815	COG1827	regulation of RNA biosynthetic process
TTHE_RS10840	COG1126	abc transporter atp-binding protein
TTHE_RS10845	COG0765	amino acid transport
TTHE_RS10850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TTHE_RS10865	COG1516	flagellar protein fliS
TTHE_RS10870	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TTHE_RS10885	COG0632	four-way junction helicase activity
TTHE_RS10925	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TTHE_RS10930	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TTHE_RS10940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TTHE_RS10945	COG4786	Flagellar basal body rod
TTHE_RS10945	COG1256	bacterial-type flagellum assembly
TTHE_RS10965	COG1040	competence protein
TTHE_RS10970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TTHE_RS10980	COG2199	diguanylate cyclase activity
TTHE_RS10980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TTHE_RS10985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TTHE_RS10990	COG1592	Rubrerythrin
TTHE_RS11040	COG5002	protein histidine kinase activity
TTHE_RS11045	COG0745	RESPONSE REGULATOR receiver
TTHE_RS11050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TTHE_RS11055	COG1609	Transcriptional regulator
TTHE_RS11060	COG0561	phosphatase activity
TTHE_RS11065	COG2323	membrane
TTHE_RS11110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TTHE_RS11120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TTHE_RS11125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TTHE_RS11130	COG3711	transcriptional antiterminator
TTHE_RS11135	COG0840	transmembrane signaling receptor activity
TTHE_RS11150	COG0295	cytidine deaminase activity
TTHE_RS11155	COG2188	Transcriptional regulator
TTHE_RS11160	COG1079	Belongs to the binding-protein-dependent transport system permease family
TTHE_RS11165	COG4603	Belongs to the binding-protein-dependent transport system permease family
TTHE_RS11170	COG3845	ABC transporter
TTHE_RS11175	COG1744	ABC transporter substrate-binding protein PnrA-like
TTHE_RS11180	COG3404	Formiminotransferase-cyclodeaminase
TTHE_RS11240	COG0484	heat shock protein binding
TTHE_RS11270	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
TTHE_RS11275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TTHE_RS11300	COG1797	cobyrinic acid a,c-diamide synthase activity
TTHE_RS11305	COG1120	ATPase activity
TTHE_RS11310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TTHE_RS11315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TTHE_RS11370	COG1131	(ABC) transporter
TTHE_RS11395	COG1131	(ABC) transporter
TTHE_RS11440	COG0116	Belongs to the methyltransferase superfamily
TTHE_RS11445	COG2226	methyltransferase
TTHE_RS11455	COG1522	sequence-specific DNA binding
TTHE_RS11460	COG0436	Aminotransferase
TTHE_RS11475	COG0671	phosphoesterase, PA-phosphatase related
TTHE_RS11485	COG0803	Belongs to the bacterial solute-binding protein 9 family
TTHE_RS11490	COG1121	(ABC) transporter
TTHE_RS11495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TTHE_RS11510	COG1132	(ABC) transporter
TTHE_RS11520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TTHE_RS11525	COG1136	(ABC) transporter
TTHE_RS11535	COG1136	(ABC) transporter
TTHE_RS11545	COG1136	(ABC) transporter
TTHE_RS11565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TTHE_RS11655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TTHE_RS11670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TTHE_RS11675	COG0737	Belongs to the 5'-nucleotidase family
TTHE_RS11690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TTHE_RS11690	COG1263	PTS System
TTHE_RS11695	COG2190	(PTS) system
TTHE_RS11700	COG1737	Transcriptional regulator
TTHE_RS11705	COG1486	melibiose metabolic process
TTHE_RS11715	COG1447	Phosphotransferase system cellobiose-specific component IIA
TTHE_RS11725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TTHE_RS11735	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TTHE_RS11735	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TTHE_RS11740	COG0531	amino acid
TTHE_RS11745	COG4166	transmembrane transport
TTHE_RS11760	COG0495	leucyl-tRNA aminoacylation
TTHE_RS11780	COG0436	Aminotransferase
TTHE_RS11785	COG4214	carbohydrate transport
TTHE_RS11795	COG4213	ABC transporter substrate-binding protein
TTHE_RS11800	COG4213	ABC transporter substrate-binding protein
TTHE_RS11805	COG2207	Transcriptional regulator
TTHE_RS11805	COG4753	response regulator
TTHE_RS11810	COG3275	phosphorelay sensor kinase activity
TTHE_RS11835	COG4211	Belongs to the binding-protein-dependent transport system permease family
TTHE_RS11850	COG1028	Short-chain dehydrogenase reductase Sdr
TTHE_RS11855	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TTHE_RS11860	COG1609	Transcriptional regulator
TTHE_RS11875	COG0246	Mannitol dehydrogenase
TTHE_RS11880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TTHE_RS11885	COG1070	Carbohydrate kinase
TTHE_RS11890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TTHE_RS11900	COG1349	DNA-binding transcription factor activity
TTHE_RS11910	COG0534	Mate efflux family protein
TTHE_RS11915	COG2721	sulfolactate sulfo-lyase activity
TTHE_RS11920	COG0246	Mannitol dehydrogenase
TTHE_RS11925	COG1486	melibiose metabolic process
TTHE_RS11935	COG0395	ABC-type sugar transport system, permease component
TTHE_RS11940	COG1175	transmembrane transport
TTHE_RS11950	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
TTHE_RS11955	COG1609	Transcriptional regulator
TTHE_RS11960	COG1904	glucuronate isomerase
TTHE_RS11975	COG1388	LysM domain
TTHE_RS11975	COG0791	NLP P60 protein
TTHE_RS11985	COG0493	'glutamate synthase
TTHE_RS12000	COG0039	L-malate dehydrogenase activity
TTHE_RS12020	COG0586	Pfam SNARE associated Golgi protein
TTHE_RS12025	COG0297	glycogen (starch) synthase activity
TTHE_RS12035	COG1085	galactose-1-phosphate uridylyltransferase
TTHE_RS12060	COG1486	melibiose metabolic process
TTHE_RS12090	COG4716	Myosin-crossreactive antigen
TTHE_RS12100	COG3875	lactate racemase activity
TTHE_RS12105	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TTHE_RS12115	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TTHE_RS12140	COG0534	Mate efflux family protein
TTHE_RS12145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TTHE_RS12155	COG2217	Heavy metal translocating P-type atpase
TTHE_RS12170	COG0864	Transcriptional regulator
TTHE_RS12175	COG0310	cobalt ion transport
TTHE_RS12180	COG0310	cobalt ion transport
TTHE_RS12190	COG1122	ATPase activity
TTHE_RS12210	COG1595	DNA-templated transcription, initiation
TTHE_RS12230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TTHE_RS12245	COG2721	sulfolactate sulfo-lyase activity
TTHE_RS12250	COG0698	ribose 5-phosphate isomerase
TTHE_RS12255	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TTHE_RS12260	COG0800	Aldolase
TTHE_RS12265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TTHE_RS12275	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TTHE_RS12280	COG3716	PTS system mannose fructose sorbose family IID component
TTHE_RS12290	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TTHE_RS12290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TTHE_RS12295	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TTHE_RS12295	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TTHE_RS12335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TTHE_RS12345	COG1609	Transcriptional regulator
TTHE_RS12350	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TTHE_RS12360	COG1472	Belongs to the glycosyl hydrolase 3 family
TTHE_RS12365	COG4214	carbohydrate transport
TTHE_RS12375	COG4213	ABC transporter substrate-binding protein
TTHE_RS12380	COG1070	Carbohydrate kinase
TTHE_RS12385	COG2115	Belongs to the xylose isomerase family
TTHE_RS12390	COG3973	AAA domain
TTHE_RS12395	COG2267	carboxylic ester hydrolase activity
TTHE_RS12400	COG1902	pentaerythritol trinitrate reductase activity
TTHE_RS12400	COG0446	pyridine nucleotide-disulphide oxidoreductase
TTHE_RS12405	COG0583	DNA-binding transcription factor activity
TTHE_RS12420	COG5434	Belongs to the glycosyl hydrolase 28 family
TTHE_RS12420	COG4632	Exopolysaccharide biosynthesis protein
TTHE_RS12425	COG1979	alcohol dehydrogenase
TTHE_RS12430	COG0840	transmembrane signaling receptor activity
TTHE_RS12435	COG1496	oxidoreductase activity
TTHE_RS12450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TTHE_RS12465	COG4786	Flagellar basal body rod
TTHE_RS12475	COG1609	Transcriptional regulator
TTHE_RS12485	COG2385	sporulation resulting in formation of a cellular spore
TTHE_RS12520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TTHE_RS12525	COG0531	amino acid
TTHE_RS12535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TTHE_RS12545	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TTHE_RS12550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TTHE_RS12565	COG0698	ribose 5-phosphate isomerase
TTHE_RS12570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TTHE_RS12575	COG0009	L-threonylcarbamoyladenylate synthase
TTHE_RS12590	COG2890	protein-(glutamine-N5) methyltransferase activity
TTHE_RS12595	COG3872	metal-dependent enzyme
TTHE_RS12605	COG0254	rRNA binding
TTHE_RS12610	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TTHE_RS12625	COG0745	RESPONSE REGULATOR receiver
TTHE_RS12630	COG2247	cell wall binding repeat
TTHE_RS12630	COG0860	N-Acetylmuramoyl-L-alanine amidase
TTHE_RS12640	COG1132	(ABC) transporter
TTHE_RS12645	COG1132	(ABC) transporter
TTHE_RS12665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TTHE_RS12665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TTHE_RS12665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TTHE_RS12670	COG1105	Belongs to the carbohydrate kinase PfkB family
TTHE_RS12675	COG1349	DNA-binding transcription factor activity
TTHE_RS12700	COG1216	Glycosyl transferase, family 2
TTHE_RS12710	COG0463	Glycosyl transferase, family 2
TTHE_RS12730	COG2205	protein histidine kinase activity
TTHE_RS12730	COG2770	Histidine kinase
TTHE_RS12735	COG0745	RESPONSE REGULATOR receiver
TTHE_RS12745	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TTHE_RS12770	COG1566	PFAM secretion protein HlyD family protein
TTHE_RS12775	COG2814	Major facilitator Superfamily
TTHE_RS12785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TTHE_RS12805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TTHE_RS12820	COG2373	Large extracellular alpha-helical protein
TTHE_RS12840	COG0504	CTP synthase activity
TTHE_RS12845	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TTHE_RS12870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TTHE_RS12875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TTHE_RS12880	COG1929	Belongs to the glycerate kinase type-1 family
TTHE_RS12885	COG3409	Peptidoglycan-binding domain 1 protein
TTHE_RS12885	COG0793	Belongs to the peptidase S41A family
TTHE_RS12890	COG0083	homoserine kinase activity
TTHE_RS12895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TTHE_RS12900	COG0460	homoserine dehydrogenase
TTHE_RS12915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TTHE_RS12920	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTHE_RS12920	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TTHE_RS12925	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTHE_RS12930	COG1132	(ABC) transporter
TTHE_RS12940	COG1846	Transcriptional regulator
TTHE_RS12955	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TTHE_RS12960	COG1518	maintenance of DNA repeat elements
TTHE_RS13020	COG1337	RAMP superfamily
TTHE_RS13055	COG0822	iron-sulfur transferase activity
TTHE_RS13060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TTHE_RS13065	COG0719	Fe-S assembly protein
TTHE_RS13070	COG0719	Fe-S assembly protein
TTHE_RS13110	COG1012	belongs to the aldehyde dehydrogenase family
TTHE_RS13110	COG1454	alcohol dehydrogenase
TTHE_RS13120	COG0667	Aldo Keto reductase
TTHE_RS13140	COG1924	4 iron, 4 sulfur cluster binding
TTHE_RS13145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TTHE_RS13160	COG1653	transport
TTHE_RS13165	COG2972	Histidine kinase
TTHE_RS13170	COG2207	Transcriptional regulator
TTHE_RS13170	COG4753	response regulator
TTHE_RS13260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TTHE_RS13265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TTHE_RS13270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TTHE_RS13290	COG5002	protein histidine kinase activity
TTHE_RS13295	COG0745	RESPONSE REGULATOR receiver
TTHE_RS13305	COG0739	heme binding
TTHE_RS13350	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TTHE_RS13355	COG1518	maintenance of DNA repeat elements
TTHE_RS13380	COG1203	CRISPR-associated helicase, Cas3
TTHE_RS13435	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TTHE_RS13460	COG2205	protein histidine kinase activity
TTHE_RS13460	COG2770	Histidine kinase
TTHE_RS13465	COG0745	RESPONSE REGULATOR receiver
TTHE_RS13475	COG2239	Acts as a magnesium transporter
TTHE_RS13495	COG0305	Participates in initiation and elongation during chromosome replication
TTHE_RS13505	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TTHE_RS13525	COG0629	single-stranded DNA binding
TTHE_RS13530	COG0360	Binds together with S18 to 16S ribosomal RNA
TTHE_RS13535	COG4481	Protein conserved in bacteria
TTHE_RS13540	COG0668	transmembrane transport
TTHE_RS13555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TTHE_RS13555	COG0189	ligase activity
TTHE_RS13565	COG1597	lipid kinase activity
TTHE_RS13575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TTHE_RS13580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TTHE_RS13585	COG1475	DNA binding
TTHE_RS13590	COG1192	Involved in chromosome partitioning
TTHE_RS13595	COG1475	DNA binding
TTHE_RS13605	COG0357	Ribosomal RNA small subunit methyltransferase G
TTHE_RS13615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TTHE_RS13620	COG1847	R3H domain protein
TTHE_RS13625	COG0706	membrane insertase activity
TTHE_RS13655	COG0641	radical SAM
TTHE_RS13775	COG0457	Tetratricopeptide repeat
TTHE_RS13775	COG0463	Glycosyl transferase, family 2
TTHE_RS13800	COG3693	PFAM glycoside hydrolase, family 10