locus-tag	class	description
THETHE_RS00015	COG0592	DNA-directed DNA polymerase activity
THETHE_RS00020	COG2501	S4 domain
THETHE_RS00045	COG0187	DNA topoisomerase II activity
THETHE_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THETHE_RS00065	COG0440	acetolactate synthase activity
THETHE_RS00070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THETHE_RS00075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THETHE_RS00085	COG0066	3-isopropylmalate dehydratase activity
THETHE_RS00090	COG0473	3-isopropylmalate dehydrogenase activity
THETHE_RS00095	COG0129	dihydroxy-acid dehydratase activity
THETHE_RS00100	COG0028	Belongs to the TPP enzyme family
THETHE_RS00155	COG1316	TRANSCRIPTIONal
THETHE_RS00160	COG1615	UPF0182 protein
THETHE_RS00185	COG0590	tRNA wobble adenosine to inosine editing
THETHE_RS00200	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THETHE_RS00200	COG2199	diguanylate cyclase activity
THETHE_RS00205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THETHE_RS00210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THETHE_RS00215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THETHE_RS00220	COG0460	homoserine dehydrogenase
THETHE_RS00230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THETHE_RS00240	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THETHE_RS00285	COG1028	Short-chain dehydrogenase reductase Sdr
THETHE_RS00290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THETHE_RS00305	COG1187	pseudouridine synthase activity
THETHE_RS00310	COG1882	Formate acetyltransferase
THETHE_RS00315	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
THETHE_RS00320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THETHE_RS00325	COG1028	Short-chain dehydrogenase reductase Sdr
THETHE_RS00340	COG1573	uracil-dna glycosylase
THETHE_RS00355	COG1940	carbohydrate kinase activity
THETHE_RS00360	COG0519	Catalyzes the synthesis of GMP from XMP
THETHE_RS00370	COG1982	Orn Lys Arg decarboxylase major
THETHE_RS00380	COG3870	Protein conserved in bacteria
THETHE_RS00395	COG1774	PSP1 C-terminal conserved region
THETHE_RS00405	COG0730	response to heat
THETHE_RS00415	COG2235	arginine
THETHE_RS00420	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
THETHE_RS00425	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THETHE_RS00430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THETHE_RS00435	COG2002	toxin-antitoxin pair type II binding
THETHE_RS00440	COG2715	membrane protein required for spore maturation
THETHE_RS00445	COG0700	Nucleoside recognition
THETHE_RS00450	COG0617	tRNA 3'-terminal CCA addition
THETHE_RS00455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THETHE_RS00455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THETHE_RS00480	COG0084	hydrolase, TatD family'
THETHE_RS00490	COG3584	3D domain protein
THETHE_RS00490	COG3583	domain protein
THETHE_RS00495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THETHE_RS00515	COG0489	protein tyrosine kinase activity
THETHE_RS00545	COG2111	Na H antiporter
THETHE_RS00545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THETHE_RS00555	COG3260	NADH ubiquinone oxidoreductase 20
THETHE_RS00570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THETHE_RS00575	COG0375	protein maturation
THETHE_RS00585	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THETHE_RS00590	COG0298	carbon dioxide binding
THETHE_RS00595	COG0409	Hydrogenase expression formation protein
THETHE_RS00605	COG3773	Cell wall hydrolase
THETHE_RS00605	COG3409	Peptidoglycan-binding domain 1 protein
THETHE_RS00630	COG1131	(ABC) transporter
THETHE_RS00640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THETHE_RS00810	COG0789	Transcriptional regulator
THETHE_RS00815	COG1664	Polymer-forming cytoskeletal
THETHE_RS00825	COG0071	Belongs to the small heat shock protein (HSP20) family
THETHE_RS00835	COG1609	Transcriptional regulator
THETHE_RS00840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THETHE_RS00845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THETHE_RS00855	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THETHE_RS00860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THETHE_RS00870	COG5002	protein histidine kinase activity
THETHE_RS00870	COG3850	Histidine kinase
THETHE_RS00875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THETHE_RS00890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THETHE_RS00895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THETHE_RS00900	COG2002	toxin-antitoxin pair type II binding
THETHE_RS00910	COG4466	Protein conserved in bacteria
THETHE_RS00920	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THETHE_RS00925	COG1802	Transcriptional regulator
THETHE_RS00940	COG0697	spore germination
THETHE_RS00945	COG0531	amino acid
THETHE_RS00960	COG1982	Orn Lys Arg decarboxylase major
THETHE_RS00970	COG2959	enzyme of heme biosynthesis
THETHE_RS00985	COG1175	transmembrane transport
THETHE_RS00990	COG0395	ABC-type sugar transport system, permease component
THETHE_RS00995	COG1609	Transcriptional regulator
THETHE_RS01020	COG0018	arginyl-trna synthetase
THETHE_RS01030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THETHE_RS01035	COG1131	(ABC) transporter
THETHE_RS01045	COG0531	amino acid
THETHE_RS01055	COG0667	Aldo Keto reductase
THETHE_RS01065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THETHE_RS01070	COG3859	Proton-coupled thiamine transporter YuaJ
THETHE_RS01075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THETHE_RS01080	COG0671	phosphoesterase, PA-phosphatase related
THETHE_RS01110	COG5434	Belongs to the glycosyl hydrolase 28 family
THETHE_RS01110	COG4632	Exopolysaccharide biosynthesis protein
THETHE_RS01115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THETHE_RS01155	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THETHE_RS01160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THETHE_RS01170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THETHE_RS01175	COG0505	Belongs to the CarA family
THETHE_RS01200	COG0446	pyridine nucleotide-disulphide oxidoreductase
THETHE_RS01205	COG0586	Pfam SNARE associated Golgi protein
THETHE_RS01220	COG2033	superoxide reductase activity
THETHE_RS01225	COG1027	Aspartate ammonia-lyase
THETHE_RS01230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THETHE_RS01235	COG2211	Major facilitator Superfamily
THETHE_RS01245	COG3956	TIGRFAM MazG family protein
THETHE_RS01250	COG0776	regulation of translation
THETHE_RS01255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THETHE_RS01260	COG2385	sporulation resulting in formation of a cellular spore
THETHE_RS01290	COG1098	S1 RNA binding domain
THETHE_RS01295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THETHE_RS01295	COG0248	Ppx GppA phosphatase
THETHE_RS01325	COG0840	transmembrane signaling receptor activity
THETHE_RS01345	COG0653	protein targeting
THETHE_RS01365	COG0860	N-Acetylmuramoyl-L-alanine amidase
THETHE_RS01375	COG2233	PERMEase
THETHE_RS01385	COG0842	Transport permease protein
THETHE_RS01390	COG1131	(ABC) transporter
THETHE_RS01400	COG1309	transcriptional regulator
THETHE_RS01405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THETHE_RS01405	COG1013	pyruvate-flavodoxin oxidoreductase activity
THETHE_RS01405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THETHE_RS01405	COG0674	pyruvate-flavodoxin oxidoreductase activity
THETHE_RS01425	COG1131	(ABC) transporter
THETHE_RS01435	COG1595	DNA-templated transcription, initiation
THETHE_RS01445	COG3830	Belongs to the UPF0237 family
THETHE_RS01455	COG2226	methyltransferase
THETHE_RS01480	COG2226	methyltransferase
THETHE_RS01490	COG2208	phosphoserine phosphatase activity
THETHE_RS01505	COG0037	tRNA processing
THETHE_RS01510	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THETHE_RS01530	COG5002	protein histidine kinase activity
THETHE_RS01545	COG3547	Transposase (IS116 IS110 IS902 family)
THETHE_RS01550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THETHE_RS01555	COG4770	biotin carboxylase activity
THETHE_RS01560	COG4684	Psort location CytoplasmicMembrane, score
THETHE_RS01575	COG0697	spore germination
THETHE_RS01600	COG5322	oxidoreductase activity
THETHE_RS01600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THETHE_RS01610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THETHE_RS01620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THETHE_RS01625	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THETHE_RS01630	COG0720	synthase
THETHE_RS01640	COG4224	UPF0291 protein
THETHE_RS01660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THETHE_RS01665	COG2203	Gaf domain
THETHE_RS01665	COG2199	diguanylate cyclase activity
THETHE_RS01670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THETHE_RS01675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THETHE_RS01680	COG0281	malic enzyme
THETHE_RS01695	COG3880	PFAM UvrB UvrC protein
THETHE_RS01700	COG3869	Catalyzes the specific phosphorylation of arginine residues in
THETHE_RS01705	COG0542	response to heat
THETHE_RS01710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THETHE_RS01720	COG4956	integral membrane protein (PIN domain superfamily)
THETHE_RS01725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THETHE_RS01735	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THETHE_RS01750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THETHE_RS01755	COG1045	serine acetyltransferase
THETHE_RS01770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THETHE_RS01775	COG3688	RNA-binding protein containing a PIN domain
THETHE_RS01780	COG1595	DNA-templated transcription, initiation
THETHE_RS01790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THETHE_RS01795	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THETHE_RS01800	COG0250	Participates in transcription elongation, termination and antitermination
THETHE_RS01820	COG0222	ribosome binding
THETHE_RS01825	COG0085	RNA polymerase activity
THETHE_RS01840	COG1358	cellular component organization or biogenesis
THETHE_RS01845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THETHE_RS01850	COG0049	tRNA binding
THETHE_RS01860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THETHE_RS01870	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THETHE_RS01895	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THETHE_RS01900	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THETHE_RS01905	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THETHE_RS01935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THETHE_RS01945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THETHE_RS01960	COG1841	ribosomal large subunit assembly
THETHE_RS01970	COG0201	protein transport
THETHE_RS01990	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THETHE_RS01995	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THETHE_RS02005	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THETHE_RS02025	COG1122	ATPase activity
THETHE_RS02030	COG1122	ATPase activity
THETHE_RS02035	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THETHE_RS02045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THETHE_RS02110	COG1609	Transcriptional regulator
THETHE_RS02120	COG1175	transmembrane transport
THETHE_RS02135	COG1621	beta-fructofuranosidase activity
THETHE_RS02165	COG4974	Belongs to the 'phage' integrase family
THETHE_RS02170	COG4974	Belongs to the 'phage' integrase family
THETHE_RS02175	COG4974	Belongs to the 'phage' integrase family
THETHE_RS02200	COG1349	DNA-binding transcription factor activity
THETHE_RS02205	COG0434	BtpA family
THETHE_RS02220	COG1070	Carbohydrate kinase
THETHE_RS02240	COG3344	reverse transcriptase
THETHE_RS02255	COG1136	(ABC) transporter
THETHE_RS02260	COG1136	(ABC) transporter
THETHE_RS02260	COG0577	efflux transmembrane transporter activity
THETHE_RS02315	COG0714	Associated with various cellular activities
THETHE_RS02320	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
THETHE_RS02325	COG1305	Transglutaminase-like
THETHE_RS02335	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
THETHE_RS02375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THETHE_RS02385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THETHE_RS02390	COG1733	regulation of RNA biosynthetic process
THETHE_RS02440	COG3464	Transposase
THETHE_RS02490	COG0454	-acetyltransferase
THETHE_RS02500	COG0561	phosphatase activity
THETHE_RS02505	COG2703	oxygen carrier activity
THETHE_RS02515	COG3973	AAA domain
THETHE_RS02520	COG0432	Pfam Uncharacterised protein family UPF0047
THETHE_RS02535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THETHE_RS02535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THETHE_RS02545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THETHE_RS02555	COG2337	Toxic component of a toxin-antitoxin (TA) module
THETHE_RS02560	COG3547	Transposase (IS116 IS110 IS902 family)
THETHE_RS02580	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
THETHE_RS02585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THETHE_RS02595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THETHE_RS02600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
THETHE_RS02615	COG3344	reverse transcriptase
THETHE_RS02620	COG1773	rubredoxin
THETHE_RS02625	COG0673	inositol 2-dehydrogenase activity
THETHE_RS02640	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
THETHE_RS02640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THETHE_RS02645	COG3459	Glycosyltransferase 36 associated
THETHE_RS02650	COG1725	Transcriptional regulator
THETHE_RS02660	COG4377	Putative membrane peptidase family (DUF2324)
THETHE_RS02665	COG0330	HflC and HflK could
THETHE_RS02675	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THETHE_RS02685	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THETHE_RS02695	COG0131	Imidazoleglycerol-phosphate dehydratase
THETHE_RS02700	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THETHE_RS02715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THETHE_RS02715	COG0140	phosphoribosyl-ATP diphosphatase activity
THETHE_RS02720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THETHE_RS02745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THETHE_RS02770	COG0640	Transcriptional regulator
THETHE_RS02785	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THETHE_RS02790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THETHE_RS02795	COG0640	Transcriptional regulator
THETHE_RS02805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THETHE_RS02815	COG0579	oxidoreductase
THETHE_RS02820	COG0446	pyridine nucleotide-disulphide oxidoreductase
THETHE_RS02830	COG3829	transcription factor binding
THETHE_RS02830	COG3290	protein histidine kinase activity
THETHE_RS02835	COG2376	Dihydroxyacetone kinase
THETHE_RS02845	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
THETHE_RS02855	COG0443	Heat shock 70 kDa protein
THETHE_RS02890	COG0849	cell division
THETHE_RS02915	COG1131	(ABC) transporter
THETHE_RS02945	COG3842	ATPase activity
THETHE_RS02960	COG0437	4 iron, 4 sulfur cluster binding
THETHE_RS02965	COG0069	glutamate synthase activity
THETHE_RS02970	COG0067	glutamate synthase
THETHE_RS02975	COG3835	regulator
THETHE_RS02980	COG2884	Cell division ATP-binding protein ftsE
THETHE_RS02985	COG2177	Part of the ABC transporter FtsEX involved in
THETHE_RS02990	COG0739	heme binding
THETHE_RS02995	COG0793	Belongs to the peptidase S41A family
THETHE_RS03000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THETHE_RS03005	COG2045	Belongs to the ComB family
THETHE_RS03010	COG0556	nucleotide-excision repair
THETHE_RS03020	COG1716	ATPase activity
THETHE_RS03030	COG0768	penicillin binding
THETHE_RS03045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THETHE_RS03055	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THETHE_RS03055	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THETHE_RS03060	COG3711	transcriptional antiterminator
THETHE_RS03065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THETHE_RS03065	COG1263	PTS System
THETHE_RS03065	COG2190	(PTS) system
THETHE_RS03070	COG2723	6-phospho-beta-galactosidase activity
THETHE_RS03090	COG0318	PFAM AMP-dependent synthetase and ligase
THETHE_RS03100	COG0673	inositol 2-dehydrogenase activity
THETHE_RS03115	COG0673	inositol 2-dehydrogenase activity
THETHE_RS03120	COG3250	beta-galactosidase activity
THETHE_RS03125	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THETHE_RS03125	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THETHE_RS03135	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
THETHE_RS03155	COG2723	6-phospho-beta-galactosidase activity
THETHE_RS03160	COG3534	alpha-L-arabinofuranosidase
THETHE_RS03165	COG1653	transport
THETHE_RS03170	COG1175	transmembrane transport
THETHE_RS03175	COG0395	ABC-type sugar transport system, permease component
THETHE_RS03190	COG3507	Belongs to the glycosyl hydrolase 43 family
THETHE_RS03195	COG2160	L-arabinose isomerase activity
THETHE_RS03200	COG1069	ribulokinase activity
THETHE_RS03205	COG0235	Class ii aldolase
THETHE_RS03215	COG1609	Transcriptional regulator
THETHE_RS03220	COG0371	Dehydrogenase
THETHE_RS03245	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
THETHE_RS03250	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THETHE_RS03255	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THETHE_RS03260	COG1940	carbohydrate kinase activity
THETHE_RS03265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THETHE_RS03295	COG1477	protein flavinylation
THETHE_RS03305	COG0768	penicillin binding
THETHE_RS03310	COG3285	dna ligase
THETHE_RS03310	COG1793	dna ligase
THETHE_RS03315	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
THETHE_RS03320	COG1388	LysM domain
THETHE_RS03320	COG0791	NLP P60 protein
THETHE_RS03325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THETHE_RS03340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
THETHE_RS03340	COG2755	lipolytic protein G-D-S-L family
THETHE_RS03345	COG0531	amino acid
THETHE_RS03350	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
THETHE_RS03370	COG2608	mercury ion transmembrane transporter activity
THETHE_RS03415	COG1796	DNA polymerase
THETHE_RS03415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THETHE_RS03420	COG2873	o-acetylhomoserine
THETHE_RS03435	COG4942	peptidase
THETHE_RS03455	COG1914	H( )-stimulated, divalent metal cation uptake system
THETHE_RS03465	COG2226	methyltransferase
THETHE_RS03475	COG0785	Cytochrome C biogenesis protein
THETHE_RS03495	COG3852	Histidine kinase
THETHE_RS03500	COG2204	response regulator
THETHE_RS03515	COG2217	Heavy metal translocating P-type atpase
THETHE_RS03520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THETHE_RS03525	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THETHE_RS03530	COG1660	Displays ATPase and GTPase activities
THETHE_RS03540	COG1653	transport
THETHE_RS03560	COG1175	transmembrane transport
THETHE_RS03565	COG3833	ABC-type maltose transport systems, permease component
THETHE_RS03580	COG1426	Protein conserved in bacteria
THETHE_RS03585	COG0366	Alpha amylase catalytic
THETHE_RS03595	COG1481	regulation of sporulation
THETHE_RS03600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THETHE_RS03605	COG4109	DRTGG domain
THETHE_RS03640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THETHE_RS03680	COG0778	Nitroreductase
THETHE_RS03750	COG1199	ATP-dependent helicase activity
THETHE_RS03760	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
THETHE_RS03760	COG3064	Membrane
THETHE_RS03760	COG1073	alpha beta
THETHE_RS03765	COG2195	Cleaves the N-terminal amino acid of tripeptides
THETHE_RS03770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THETHE_RS03775	COG0778	Nitroreductase
THETHE_RS03800	COG4656	Part of a membrane complex involved in electron transport
THETHE_RS03805	COG4658	electron transport chain
THETHE_RS03810	COG4659	FMN binding
THETHE_RS03815	COG4660	Part of a membrane complex involved in electron transport
THETHE_RS03820	COG4657	Part of a membrane complex involved in electron transport
THETHE_RS03825	COG2878	Part of a membrane complex involved in electron transport
THETHE_RS03840	COG0646	methionine synthase
THETHE_RS03840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THETHE_RS03845	COG0646	methionine synthase
THETHE_RS03845	COG1410	methionine synthase
THETHE_RS03850	COG3546	catalase activity
THETHE_RS03870	COG1598	PFAM Uncharacterised protein family UPF0150
THETHE_RS03875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THETHE_RS03895	COG5002	protein histidine kinase activity
THETHE_RS03925	COG0655	NAD(P)H dehydrogenase (quinone) activity
THETHE_RS03945	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
THETHE_RS03965	COG0667	Aldo Keto reductase
THETHE_RS03985	COG0789	Transcriptional regulator
THETHE_RS04005	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THETHE_RS04010	COG1234	tRNA 3'-trailer cleavage
THETHE_RS04025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THETHE_RS04035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THETHE_RS04045	COG0356	it plays a direct role in the translocation of protons across the membrane
THETHE_RS04050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THETHE_RS04055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THETHE_RS04060	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THETHE_RS04065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THETHE_RS04070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THETHE_RS04075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THETHE_RS04080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THETHE_RS04095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THETHE_RS04095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THETHE_RS04100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THETHE_RS04105	COG1116	anion transmembrane transporter activity
THETHE_RS04110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THETHE_RS04120	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
THETHE_RS04165	COG0438	transferase activity, transferring glycosyl groups
THETHE_RS04170	COG1045	serine acetyltransferase
THETHE_RS04180	COG0438	transferase activity, transferring glycosyl groups
THETHE_RS04185	COG0110	maltose O-acetyltransferase activity
THETHE_RS04195	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
THETHE_RS04205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THETHE_RS04210	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
THETHE_RS04230	COG0513	Belongs to the DEAD box helicase family
THETHE_RS04330	COG1131	(ABC) transporter
THETHE_RS04350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THETHE_RS04350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THETHE_RS04350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THETHE_RS04355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THETHE_RS04360	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
THETHE_RS04360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THETHE_RS04360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THETHE_RS04385	COG1879	ABC-type sugar transport system periplasmic component
THETHE_RS04390	COG4603	Belongs to the binding-protein-dependent transport system permease family
THETHE_RS04395	COG1129	ABC transporter
THETHE_RS04400	COG1172	Belongs to the binding-protein-dependent transport system permease family
THETHE_RS04405	COG1472	Belongs to the glycosyl hydrolase 3 family
THETHE_RS04490	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THETHE_RS04505	COG1802	Transcriptional regulator
THETHE_RS04510	COG1312	Catalyzes the dehydration of D-mannonate
THETHE_RS04515	COG4209	transmembrane transport
THETHE_RS04520	COG0395	ABC-type sugar transport system, permease component
THETHE_RS04540	COG0673	inositol 2-dehydrogenase activity
THETHE_RS04555	COG3664	PFAM glycoside hydrolase family 39
THETHE_RS04560	COG3458	cephalosporin-C deacetylase activity
THETHE_RS04570	COG3275	phosphorelay sensor kinase activity
THETHE_RS04575	COG1653	transport
THETHE_RS04580	COG1175	transmembrane transport
THETHE_RS04585	COG0395	ABC-type sugar transport system, permease component
THETHE_RS04615	COG1335	isochorismatase
THETHE_RS04635	COG1136	(ABC) transporter
THETHE_RS04645	COG1942	4-Oxalocrotonate Tautomerase
THETHE_RS04685	COG3944	biosynthesis protein
THETHE_RS04690	COG0489	protein tyrosine kinase activity
THETHE_RS04695	COG4464	protein tyrosine phosphatase activity
THETHE_RS04700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THETHE_RS04710	COG3344	reverse transcriptase
THETHE_RS04725	COG3949	Membrane
THETHE_RS04735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THETHE_RS04750	COG2814	Major facilitator Superfamily
THETHE_RS04765	COG0426	domain, Protein
THETHE_RS04770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THETHE_RS04775	COG0671	phosphoesterase, PA-phosphatase related
THETHE_RS04785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THETHE_RS04790	COG1606	tRNA processing
THETHE_RS04795	COG1691	(AIR) carboxylase
THETHE_RS04800	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THETHE_RS04805	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THETHE_RS04810	COG1268	BioY protein
THETHE_RS04815	COG0525	valine-tRNA ligase activity
THETHE_RS04825	COG0285	dihydrofolate synthase activity
THETHE_RS04860	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THETHE_RS04890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THETHE_RS04900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THETHE_RS04935	COG1252	NADH dehydrogenase
THETHE_RS04950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
THETHE_RS04955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THETHE_RS04970	COG3858	chitin binding
THETHE_RS04980	COG0739	heme binding
THETHE_RS04985	COG0438	transferase activity, transferring glycosyl groups
THETHE_RS05010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THETHE_RS05015	COG4475	Protein of unknown function (DUF436)
THETHE_RS05025	COG1388	LysM domain
THETHE_RS05025	COG3858	chitin binding
THETHE_RS05030	COG1983	PspC domain protein
THETHE_RS05035	COG1113	amino acid transport
THETHE_RS05045	COG1376	ErfK ybiS ycfS ynhG family protein
THETHE_RS05050	COG1595	DNA-templated transcription, initiation
THETHE_RS05065	COG0237	dephospho-CoA kinase activity
THETHE_RS05070	COG0741	lytic transglycosylase activity
THETHE_RS05075	COG2707	UPF0756 membrane protein
THETHE_RS05095	COG0791	NLP P60 protein
THETHE_RS05100	COG1217	gtp-binding protein TYPA
THETHE_RS05105	COG0741	lytic transglycosylase activity
THETHE_RS05120	COG2172	sigma factor antagonist activity
THETHE_RS05125	COG2878	Part of a membrane complex involved in electron transport
THETHE_RS05145	COG3290	protein histidine kinase activity
THETHE_RS05175	COG2003	Belongs to the UPF0758 family
THETHE_RS05180	COG1077	Cell shape determining protein MreB Mrl
THETHE_RS05205	COG2894	cell division
THETHE_RS05215	COG0772	Belongs to the SEDS family
THETHE_RS05225	COG1388	LysM domain
THETHE_RS05225	COG0739	heme binding
THETHE_RS05230	COG0517	IMP dehydrogenase activity
THETHE_RS05230	COG1994	Peptidase M50
THETHE_RS05245	COG1530	ribonuclease E activity
THETHE_RS05280	COG1713	HD superfamily hydrolase involved in NAD metabolism
THETHE_RS05285	COG0799	negative regulation of ribosome biogenesis
THETHE_RS05295	COG2964	Protein conserved in bacteria
THETHE_RS05300	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
THETHE_RS05305	COG1686	Belongs to the peptidase S11 family
THETHE_RS05310	COG1555	photosystem II stabilization
THETHE_RS05310	COG1596	polysaccharide export
THETHE_RS05320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THETHE_RS05325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THETHE_RS05330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THETHE_RS05355	COG0493	'glutamate synthase
THETHE_RS05395	COG3547	Transposase (IS116 IS110 IS902 family)
THETHE_RS05400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THETHE_RS05405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THETHE_RS05430	COG1131	(ABC) transporter
THETHE_RS05435	COG1846	Transcriptional regulator
THETHE_RS05450	COG1234	tRNA 3'-trailer cleavage
THETHE_RS05455	COG0658	competence protein
THETHE_RS05455	COG2333	competence protein COMEC
THETHE_RS05465	COG0268	Binds directly to 16S ribosomal RNA
THETHE_RS05475	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THETHE_RS05505	COG0481	GTPase activity
THETHE_RS05510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THETHE_RS05520	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THETHE_RS05530	COG0484	heat shock protein binding
THETHE_RS05535	COG2264	protein methyltransferase activity
THETHE_RS05540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THETHE_RS05545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THETHE_RS05550	COG0537	adenosine 5'-monophosphoramidase activity
THETHE_RS05560	COG1610	YqeY-like protein
THETHE_RS05575	COG1702	phosphate starvation-inducible protein PhoH
THETHE_RS05580	COG1480	7TM receptor with intracellular HD hydrolase
THETHE_RS05590	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THETHE_RS05615	COG0423	glycine-tRNA ligase activity
THETHE_RS05625	COG0574	Belongs to the PEP-utilizing enzyme family
THETHE_RS05625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THETHE_RS05645	COG0557	exoribonuclease II activity
THETHE_RS05675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THETHE_RS05690	COG2302	S4 RNA-binding domain
THETHE_RS05695	COG3599	regulation of cell shape
THETHE_RS05710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THETHE_RS05725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THETHE_RS05725	COG0512	Glutamine amidotransferase of anthranilate synthase
THETHE_RS05755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THETHE_RS05785	COG0582	viral genome integration into host DNA
THETHE_RS05810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THETHE_RS05820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THETHE_RS05825	COG0564	pseudouridine synthase activity
THETHE_RS05840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THETHE_RS05845	COG1937	Protein conserved in bacteria
THETHE_RS05850	COG3118	belongs to the thioredoxin family
THETHE_RS05860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THETHE_RS05865	COG1959	2 iron, 2 sulfur cluster binding
THETHE_RS05895	COG1132	(ABC) transporter
THETHE_RS05930	COG0628	permease
THETHE_RS05940	COG4472	Bacterial protein of unknown function (DUF965)
THETHE_RS05950	COG3906	Belongs to the UPF0473 family
THETHE_RS05955	COG0735	belongs to the Fur family
THETHE_RS05960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
THETHE_RS05965	COG3679	Belongs to the UPF0342 family
THETHE_RS05970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THETHE_RS05975	COG4122	O-methyltransferase activity
THETHE_RS05980	COG0826	peptidase U32
THETHE_RS05985	COG0768	penicillin binding
THETHE_RS05995	COG0546	phosphoglycolate phosphatase activity
THETHE_RS06000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THETHE_RS06005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THETHE_RS06015	COG1459	type II secretion system
THETHE_RS06025	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THETHE_RS06080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THETHE_RS06090	COG0006	proline dipeptidase activity
THETHE_RS06105	COG3854	ATPases associated with a variety of cellular activities
THETHE_RS06145	COG1302	Protein conserved in bacteria
THETHE_RS06165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THETHE_RS06170	COG1570	exodeoxyribonuclease VII activity
THETHE_RS06180	COG0142	geranyltranstransferase activity
THETHE_RS06190	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THETHE_RS06195	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
THETHE_RS06205	COG1438	arginine binding
THETHE_RS06210	COG0497	DNA recombination
THETHE_RS06215	COG0750	zinc metalloprotease
THETHE_RS06250	COG0494	nUDIX hydrolase
THETHE_RS06255	COG1379	DNA repair
THETHE_RS06260	COG1300	Membrane
THETHE_RS06265	COG4974	Belongs to the 'phage' integrase family
THETHE_RS06270	COG1686	Belongs to the peptidase S11 family
THETHE_RS06275	COG1366	Belongs to the anti-sigma-factor antagonist family
THETHE_RS06290	COG3360	Dodecin
THETHE_RS06310	COG0617	tRNA 3'-terminal CCA addition
THETHE_RS06310	COG3620	sequence-specific DNA binding
THETHE_RS06310	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THETHE_RS06315	COG1994	Peptidase M50
THETHE_RS06325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THETHE_RS06335	COG3874	Sporulation protein YtfJ
THETHE_RS06340	COG1686	Belongs to the peptidase S11 family
THETHE_RS06350	COG0445	tRNA wobble uridine modification
THETHE_RS06355	COG1187	pseudouridine synthase activity
THETHE_RS06365	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THETHE_RS06370	COG0010	Belongs to the arginase family
THETHE_RS06380	COG1388	LysM domain
THETHE_RS06400	COG0406	alpha-ribazole phosphatase activity
THETHE_RS06405	COG2081	HI0933 family
THETHE_RS06415	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THETHE_RS06425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THETHE_RS06440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THETHE_RS06455	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THETHE_RS06460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THETHE_RS06475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THETHE_RS06480	COG0328	RNA-DNA hybrid ribonuclease activity
THETHE_RS06485	COG4974	Belongs to the 'phage' integrase family
THETHE_RS06490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THETHE_RS06495	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
THETHE_RS06500	COG0464	growth
THETHE_RS06505	COG0017	Asparaginyl-tRNA synthetase
THETHE_RS06510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THETHE_RS06520	COG0613	PHP domain protein
THETHE_RS06525	COG2359	stage V sporulation protein S
THETHE_RS06530	COG1692	metallophosphoesterase
THETHE_RS06535	COG1418	mRNA catabolic process
THETHE_RS06540	COG0419	ATPase involved in DNA repair
THETHE_RS06545	COG0420	3'-5' exonuclease activity
THETHE_RS06570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THETHE_RS06575	COG1058	Belongs to the CinA family
THETHE_RS06575	COG1546	Belongs to the CinA family
THETHE_RS06580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THETHE_RS06585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THETHE_RS06590	COG1674	ftsk spoiiie
THETHE_RS06600	COG0740	serine-type endopeptidase activity
THETHE_RS06605	COG0527	aspartate kinase activity
THETHE_RS06620	COG0612	Peptidase, M16
THETHE_RS06625	COG0726	polysaccharide deacetylase
THETHE_RS06630	COG1185	polyribonucleotide nucleotidyltransferase activity
THETHE_RS06635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THETHE_RS06640	COG0196	riboflavin kinase activity
THETHE_RS06645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THETHE_RS06650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THETHE_RS06655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THETHE_RS06670	COG2740	Nucleic-acid-binding protein implicated in transcription termination
THETHE_RS06675	COG0195	Participates in both transcription termination and antitermination
THETHE_RS06680	COG0779	Required for maturation of 30S ribosomal subunits
THETHE_RS06685	COG2176	DNA-directed DNA polymerase activity
THETHE_RS06695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THETHE_RS06700	COG0750	zinc metalloprotease
THETHE_RS06705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THETHE_RS06710	COG4589	Belongs to the CDS family
THETHE_RS06715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THETHE_RS06720	COG0233	cytoplasmic translational termination
THETHE_RS06725	COG0528	UMP kinase activity
THETHE_RS06730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THETHE_RS06750	COG1191	sigma factor activity
THETHE_RS06755	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THETHE_RS06760	COG1776	CheC inhibitor of MCP methylation
THETHE_RS06770	COG2198	Histidine kinase
THETHE_RS06770	COG0643	Histidine kinase
THETHE_RS06780	COG0455	bacterial-type flagellum organization
THETHE_RS06790	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THETHE_RS06795	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THETHE_RS06800	COG1684	flagellar biosynthetic protein fliR
THETHE_RS06805	COG1987	bacterial-type flagellum assembly
THETHE_RS06810	COG1338	Plays a role in the flagellum-specific transport system
THETHE_RS06820	COG2201	protein-glutamate methylesterase activity
THETHE_RS06825	COG1776	CheC inhibitor of MCP methylation
THETHE_RS06825	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THETHE_RS06830	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THETHE_RS06835	COG1580	Controls the rotational direction of flagella during chemotaxis
THETHE_RS06840	COG1582	Flagellar protein (FlbD)
THETHE_RS06850	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THETHE_RS06870	COG1157	protein secretion by the type III secretion system
THETHE_RS06880	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THETHE_RS06885	COG1766	The M ring may be actively involved in energy transduction
THETHE_RS06890	COG1677	Flagellar hook-basal body complex protein FliE
THETHE_RS06900	COG1815	bacterial-type flagellum-dependent cell motility
THETHE_RS06910	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THETHE_RS06915	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THETHE_RS06920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THETHE_RS06925	COG0758	DNA mediated transformation
THETHE_RS06925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THETHE_RS06930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THETHE_RS06935	COG0792	nuclease activity
THETHE_RS06940	COG0180	Tryptophanyl-tRNA synthetase
THETHE_RS06945	COG0606	chelatase, subunit chli
THETHE_RS06960	COG0336	Belongs to the RNA methyltransferase TrmD family
THETHE_RS06970	COG1837	Belongs to the UPF0109 family
THETHE_RS06980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THETHE_RS06985	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
THETHE_RS07015	COG1136	(ABC) transporter
THETHE_RS07035	COG1595	DNA-templated transcription, initiation
THETHE_RS07040	COG0552	protein localization to endoplasmic reticulum
THETHE_RS07045	COG1196	nuclear chromosome segregation
THETHE_RS07050	COG2359	stage V sporulation protein S
THETHE_RS07060	COG0571	ribonuclease III activity
THETHE_RS07065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THETHE_RS07080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THETHE_RS07085	COG2070	2-Nitropropane dioxygenase
THETHE_RS07090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THETHE_RS07095	COG0416	fatty acid biosynthetic process
THETHE_RS07100	COG2030	dehydratase
THETHE_RS07105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THETHE_RS07110	COG1399	metal-binding, possibly nucleic acid-binding protein
THETHE_RS07115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THETHE_RS07120	COG0280	phosphate acetyltransferase
THETHE_RS07130	COG3314	Sporulation integral membrane protein YlbJ
THETHE_RS07140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THETHE_RS07145	COG0742	ribosomal rna small subunit methyltransferase
THETHE_RS07160	COG1307	EDD domain protein, DegV family
THETHE_RS07165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THETHE_RS07170	COG1461	Dihydroxyacetone kinase
THETHE_RS07175	COG1302	Protein conserved in bacteria
THETHE_RS07195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THETHE_RS07200	COG1162	GTPase activity
THETHE_RS07205	COG2815	serine threonine protein kinase
THETHE_RS07205	COG0515	serine threonine protein kinase
THETHE_RS07210	COG0631	protein serine/threonine phosphatase activity
THETHE_RS07220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THETHE_RS07220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THETHE_RS07225	COG2738	Putative neutral zinc metallopeptidase
THETHE_RS07235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THETHE_RS07245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THETHE_RS07250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THETHE_RS07260	COG0194	GDP metabolic process
THETHE_RS07270	COG1561	YicC-like family, N-terminal region
THETHE_RS07275	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THETHE_RS07315	COG0167	dihydroorotate dehydrogenase activity
THETHE_RS07320	COG0543	2 iron, 2 sulfur cluster binding
THETHE_RS07335	COG0540	Belongs to the ATCase OTCase family
THETHE_RS07355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THETHE_RS07365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THETHE_RS07370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THETHE_RS07375	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THETHE_RS07375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THETHE_RS07390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THETHE_RS07395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THETHE_RS07420	COG0343	queuine tRNA-ribosyltransferase activity
THETHE_RS07425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THETHE_RS07430	COG2385	sporulation resulting in formation of a cellular spore
THETHE_RS07430	COG2247	cell wall binding repeat
THETHE_RS07450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THETHE_RS07460	COG0835	chemotaxis
THETHE_RS07465	COG0217	transcriptional regulatory protein
THETHE_RS07470	COG0730	response to heat
THETHE_RS07490	COG1739	Uncharacterized protein family UPF0029
THETHE_RS07495	COG0494	nUDIX hydrolase
THETHE_RS07505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THETHE_RS07515	COG3344	reverse transcriptase
THETHE_RS07535	COG0175	sulfate reduction
THETHE_RS07540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THETHE_RS07560	COG0175	sulfate reduction
THETHE_RS07565	COG2873	o-acetylhomoserine
THETHE_RS07580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THETHE_RS07590	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
THETHE_RS07590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THETHE_RS07605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THETHE_RS07610	COG2873	o-acetylhomoserine
THETHE_RS07615	COG1464	Belongs to the NlpA lipoprotein family
THETHE_RS07620	COG2011	ABC-type metal ion transport system permease component
THETHE_RS07625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
THETHE_RS07630	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THETHE_RS07650	COG1433	Dinitrogenase iron-molybdenum cofactor
THETHE_RS07650	COG0535	radical SAM domain protein
THETHE_RS07670	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THETHE_RS07680	COG0626	cystathionine gamma-synthase activity
THETHE_RS07685	COG2873	o-acetylhomoserine
THETHE_RS07690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THETHE_RS07695	COG0626	cystathionine gamma-synthase activity
THETHE_RS07700	COG2226	methyltransferase
THETHE_RS07705	COG0113	porphobilinogen synthase activity
THETHE_RS07710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THETHE_RS07710	COG1648	precorrin-2 dehydrogenase activity
THETHE_RS07715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THETHE_RS07725	COG0181	hydroxymethylbilane synthase activity
THETHE_RS07730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THETHE_RS07735	COG4172	Belongs to the ABC transporter superfamily
THETHE_RS07740	COG0444	Belongs to the ABC transporter superfamily
THETHE_RS07750	COG0601	transmembrane transport
THETHE_RS07755	COG4166	transmembrane transport
THETHE_RS07770	COG1132	(ABC) transporter
THETHE_RS07795	COG3885	ferrous iron binding
THETHE_RS07795	COG2078	PFAM AMMECR1 domain protein
THETHE_RS07800	COG0789	Transcriptional regulator
THETHE_RS07805	COG0477	Major facilitator Superfamily
THETHE_RS07810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THETHE_RS07815	COG1982	Orn Lys Arg decarboxylase major
THETHE_RS07825	COG2205	protein histidine kinase activity
THETHE_RS07830	COG0745	RESPONSE REGULATOR receiver
THETHE_RS07840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THETHE_RS07845	COG0785	Cytochrome C biogenesis protein
THETHE_RS07850	COG0363	glucosamine-6-phosphate deaminase activity
THETHE_RS07855	COG1940	carbohydrate kinase activity
THETHE_RS07870	COG2119	membrane
THETHE_RS07875	COG3773	Cell wall hydrolase
THETHE_RS07875	COG3409	Peptidoglycan-binding domain 1 protein
THETHE_RS07880	COG5002	protein histidine kinase activity
THETHE_RS07885	COG0745	RESPONSE REGULATOR receiver
THETHE_RS07895	COG0287	Prephenate dehydrogenase
THETHE_RS07900	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THETHE_RS07905	COG1605	Chorismate mutase
THETHE_RS07905	COG0077	Prephenate dehydratase
THETHE_RS07910	COG0318	PFAM AMP-dependent synthetase and ligase
THETHE_RS07915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THETHE_RS07920	COG1760	l-serine dehydratase
THETHE_RS07930	COG1164	Oligoendopeptidase f
THETHE_RS07940	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
THETHE_RS07945	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THETHE_RS07955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THETHE_RS07970	COG0163	prenyltransferase activity
THETHE_RS07975	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THETHE_RS07980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THETHE_RS07985	COG0426	domain, Protein
THETHE_RS07990	COG3069	C4-dicarboxylate transmembrane transporter activity
THETHE_RS08005	COG1968	undecaprenyl-diphosphatase activity
THETHE_RS08010	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THETHE_RS08020	COG0584	glycerophosphoryl diester phosphodiesterase
THETHE_RS08025	COG1032	radical SAM domain protein
THETHE_RS08035	COG4086	secreted protein
THETHE_RS08040	COG3858	chitin binding
THETHE_RS08045	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
THETHE_RS08050	COG0427	acetyl-CoA hydrolase
THETHE_RS08055	COG0183	Belongs to the thiolase family
THETHE_RS08060	COG1250	3-hydroxyacyl-CoA dehydrogenase
THETHE_RS08065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THETHE_RS08070	COG2086	electron transfer activity
THETHE_RS08075	COG1960	acyl-CoA dehydrogenase activity
THETHE_RS08080	COG1024	Enoyl-CoA hydratase
THETHE_RS08085	COG3875	lactate racemase activity
THETHE_RS08090	COG0277	FAD linked oxidase domain protein
THETHE_RS08095	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THETHE_RS08100	COG2086	electron transfer activity
THETHE_RS08105	COG1620	l-lactate permease
THETHE_RS08110	COG2186	Transcriptional regulator
THETHE_RS08115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THETHE_RS08130	COG0561	phosphatase activity
THETHE_RS08170	COG3964	amidohydrolase
THETHE_RS08175	COG3711	transcriptional antiterminator
THETHE_RS08190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
THETHE_RS08195	COG3457	Alanine racemase
THETHE_RS08200	COG0626	cystathionine gamma-synthase activity
THETHE_RS08205	COG1735	metal-dependent hydrolase with the TIM-barrel fold
THETHE_RS08230	COG2188	Transcriptional regulator
THETHE_RS08245	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
THETHE_RS08250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THETHE_RS08250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THETHE_RS08255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THETHE_RS08260	COG3711	transcriptional antiterminator
THETHE_RS08260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THETHE_RS08325	COG3940	Belongs to the glycosyl hydrolase 43 family
THETHE_RS08340	COG1940	carbohydrate kinase activity
THETHE_RS08360	COG3940	Belongs to the glycosyl hydrolase 43 family
THETHE_RS08365	COG3250	beta-galactosidase activity
THETHE_RS08370	COG0395	ABC-type sugar transport system, permease component
THETHE_RS08375	COG1175	transmembrane transport
THETHE_RS08385	COG3547	Transposase (IS116 IS110 IS902 family)
THETHE_RS08400	COG1484	DNA-dependent DNA replication
THETHE_RS08420	COG1063	alcohol dehydrogenase
THETHE_RS08430	COG0191	fructose-bisphosphate aldolase activity
THETHE_RS08435	COG3547	Transposase (IS116 IS110 IS902 family)
THETHE_RS08440	COG3716	PTS system mannose fructose sorbose family IID component
THETHE_RS08445	COG3715	PTS system
THETHE_RS08450	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THETHE_RS08455	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
THETHE_RS08455	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THETHE_RS08460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THETHE_RS08460	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THETHE_RS08480	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
THETHE_RS08485	COG3547	Transposase (IS116 IS110 IS902 family)
THETHE_RS08530	COG0704	Plays a role in the regulation of phosphate uptake
THETHE_RS08535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THETHE_RS08540	COG0581	inorganic phosphate transmembrane transporter activity
THETHE_RS08545	COG0573	inorganic phosphate transmembrane transporter activity
THETHE_RS08550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THETHE_RS08555	COG5002	protein histidine kinase activity
THETHE_RS08560	COG0745	RESPONSE REGULATOR receiver
THETHE_RS08570	COG1873	PFAM PRC-barrel domain
THETHE_RS08575	COG1191	sigma factor activity
THETHE_RS08580	COG1191	sigma factor activity
THETHE_RS08590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THETHE_RS08595	COG0849	cell division
THETHE_RS08600	COG3856	small basic protein
THETHE_RS08610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
THETHE_RS08615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THETHE_RS08625	COG0772	Belongs to the SEDS family
THETHE_RS08635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THETHE_RS08640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THETHE_RS08645	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THETHE_RS08650	COG0768	penicillin binding
THETHE_RS08670	COG0612	Peptidase, M16
THETHE_RS08675	COG0612	Peptidase, M16
THETHE_RS08685	COG0012	GTP binding
THETHE_RS08715	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THETHE_RS08725	COG1937	Protein conserved in bacteria
THETHE_RS08730	COG0438	transferase activity, transferring glycosyl groups
THETHE_RS08750	COG2340	Cysteine-rich secretory protein family
THETHE_RS08755	COG1362	aminopeptidase activity
THETHE_RS08760	COG2197	response regulator
THETHE_RS08785	COG1193	negative regulation of DNA recombination
THETHE_RS08790	COG0826	peptidase U32
THETHE_RS08800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THETHE_RS08800	COG0072	phenylalanine-tRNA ligase activity
THETHE_RS08805	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THETHE_RS08810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THETHE_RS08815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THETHE_RS08820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THETHE_RS08825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THETHE_RS08830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THETHE_RS08840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THETHE_RS08845	COG4399	Belongs to the UPF0754 family
THETHE_RS08860	COG0745	RESPONSE REGULATOR receiver
THETHE_RS08875	COG0367	asparagine synthase
THETHE_RS08880	COG0347	Belongs to the P(II) protein family
THETHE_RS08895	COG0004	ammonium transporteR
THETHE_RS08900	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THETHE_RS08905	COG1691	(AIR) carboxylase
THETHE_RS08910	COG1606	tRNA processing
THETHE_RS08935	COG1546	Belongs to the CinA family
THETHE_RS08935	COG1058	Belongs to the CinA family
THETHE_RS08945	COG1414	Transcriptional regulator
THETHE_RS08975	COG0347	Belongs to the P(II) protein family
THETHE_RS08980	COG0347	Belongs to the P(II) protein family
THETHE_RS09000	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THETHE_RS09005	COG1433	Dinitrogenase iron-molybdenum cofactor
THETHE_RS09005	COG0535	radical SAM domain protein
THETHE_RS09010	COG1433	Dinitrogenase iron-molybdenum cofactor
THETHE_RS09010	COG0535	radical SAM domain protein
THETHE_RS09035	COG0352	thiamine-phosphate diphosphorylase activity
THETHE_RS09050	COG0352	thiamine-phosphate diphosphorylase activity
THETHE_RS09050	COG0351	phosphomethylpyrimidine kinase
THETHE_RS09065	COG1132	(ABC) transporter
THETHE_RS09075	COG0697	spore germination
THETHE_RS09080	COG5002	protein histidine kinase activity
THETHE_RS09100	COG1131	(ABC) transporter
THETHE_RS09110	COG1966	Carbon starvation protein
THETHE_RS09115	COG3279	Response regulator of the LytR AlgR family
THETHE_RS09120	COG3275	phosphorelay sensor kinase activity
THETHE_RS09145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THETHE_RS09180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
THETHE_RS09185	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THETHE_RS09210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THETHE_RS09215	COG3525	Glycosyl hydrolase, family 20, catalytic domain
THETHE_RS09230	COG1053	succinate dehydrogenase
THETHE_RS09240	COG0395	ABC-type sugar transport system, permease component
THETHE_RS09245	COG1175	transmembrane transport
THETHE_RS09250	COG1653	transport
THETHE_RS09255	COG1940	carbohydrate kinase activity
THETHE_RS09260	COG1737	Transcriptional regulator
THETHE_RS09265	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
THETHE_RS09275	COG3387	PFAM Glycoside hydrolase 15-related
THETHE_RS09280	COG0395	ABC-type sugar transport system, permease component
THETHE_RS09285	COG1175	transmembrane transport
THETHE_RS09295	COG1940	carbohydrate kinase activity
THETHE_RS09310	COG0800	Aldolase
THETHE_RS09315	COG4948	Mandelate Racemase Muconate Lactonizing
THETHE_RS09320	COG3775	system Galactitol-specific IIC component
THETHE_RS09330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THETHE_RS09335	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THETHE_RS09335	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THETHE_RS09355	COG1609	Transcriptional regulator
THETHE_RS09370	COG0366	Alpha amylase catalytic
THETHE_RS09375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THETHE_RS09380	COG0366	Alpha amylase catalytic
THETHE_RS09405	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THETHE_RS09410	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THETHE_RS09420	COG0395	ABC-type sugar transport system, permease component
THETHE_RS09425	COG1175	transmembrane transport
THETHE_RS09435	COG1609	Transcriptional regulator
THETHE_RS09440	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THETHE_RS09445	COG2942	2-epimerase
THETHE_RS09465	COG0346	lactoylglutathione lyase activity
THETHE_RS09480	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THETHE_RS09490	COG0569	domain protein
THETHE_RS09495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THETHE_RS09510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THETHE_RS09520	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THETHE_RS09525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THETHE_RS09535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THETHE_RS09545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THETHE_RS09555	COG5002	protein histidine kinase activity
THETHE_RS09560	COG0745	RESPONSE REGULATOR receiver
THETHE_RS09585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THETHE_RS09605	COG5002	protein histidine kinase activity
THETHE_RS09615	COG0367	asparagine synthase
THETHE_RS09615	COG0367	asparagine synthase
THETHE_RS09620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THETHE_RS09645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THETHE_RS09650	COG1070	Carbohydrate kinase
THETHE_RS09660	COG0390	transport system, permease component
THETHE_RS09665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THETHE_RS09700	COG1533	DNA photolyase activity
THETHE_RS09705	COG2222	sugar isomerase
THETHE_RS09710	COG1105	Belongs to the carbohydrate kinase PfkB family
THETHE_RS09720	COG0546	phosphoglycolate phosphatase activity
THETHE_RS09725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
THETHE_RS09740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THETHE_RS09740	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
THETHE_RS09745	COG3716	PTS system mannose fructose sorbose family IID component
THETHE_RS09750	COG3715	PTS system
THETHE_RS09755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THETHE_RS09760	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THETHE_RS09760	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THETHE_RS09765	COG1278	Cold shock
THETHE_RS09775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THETHE_RS09790	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
THETHE_RS09795	COG1902	pentaerythritol trinitrate reductase activity
THETHE_RS09805	COG1704	LemA family
THETHE_RS09810	COG1956	GAF domain-containing protein
THETHE_RS09855	COG1482	cell wall glycoprotein biosynthetic process
THETHE_RS09865	COG0482	sulfurtransferase activity
THETHE_RS09870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THETHE_RS09875	COG2384	SAM-dependent methyltransferase
THETHE_RS09890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THETHE_RS09895	COG0358	DNA primase activity
THETHE_RS09900	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THETHE_RS09905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THETHE_RS09910	COG1342	Belongs to the UPF0251 family
THETHE_RS09915	COG0148	phosphopyruvate hydratase activity
THETHE_RS09920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THETHE_RS09930	COG0126	phosphoglycerate kinase activity
THETHE_RS09945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
THETHE_RS09950	COG1254	Belongs to the acylphosphatase family
THETHE_RS09955	COG0561	phosphatase activity
THETHE_RS09960	COG0735	belongs to the Fur family
THETHE_RS09965	COG2720	vancomycin resistance protein
THETHE_RS09975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THETHE_RS09980	COG1067	ATP-dependent peptidase activity
THETHE_RS10010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THETHE_RS10015	COG1773	rubredoxin
THETHE_RS10015	COG1592	Rubrerythrin
THETHE_RS10115	COG0564	pseudouridine synthase activity
THETHE_RS10130	COG1074	ATP-dependent DNA helicase activity
THETHE_RS10140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THETHE_RS10145	COG1304	FMN binding
THETHE_RS10150	COG0778	Nitroreductase
THETHE_RS10160	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THETHE_RS10170	COG3944	biosynthesis protein
THETHE_RS10175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THETHE_RS10180	COG1511	domain protein
THETHE_RS10185	COG1309	transcriptional regulator
THETHE_RS10200	COG0463	Glycosyl transferase, family 2
THETHE_RS10200	COG0457	Tetratricopeptide repeat
THETHE_RS10220	COG0840	transmembrane signaling receptor activity
THETHE_RS10235	COG1752	Esterase of the alpha-beta hydrolase superfamily
THETHE_RS10245	COG1309	transcriptional regulator
THETHE_RS10285	COG1454	alcohol dehydrogenase
THETHE_RS10290	COG1012	belongs to the aldehyde dehydrogenase family
THETHE_RS10295	COG2096	Adenosyltransferase
THETHE_RS10300	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
THETHE_RS10310	COG4869	propanediol catabolic process
THETHE_RS10360	COG3275	phosphorelay sensor kinase activity
THETHE_RS10365	COG3344	reverse transcriptase
THETHE_RS10375	COG2197	response regulator
THETHE_RS10380	COG1070	Carbohydrate kinase
THETHE_RS10385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THETHE_RS10390	COG1012	belongs to the aldehyde dehydrogenase family
THETHE_RS10400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THETHE_RS10405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THETHE_RS10415	COG0613	PHP domain protein
THETHE_RS10420	COG0698	ribose 5-phosphate isomerase
THETHE_RS10425	COG3958	Transketolase
THETHE_RS10430	COG3959	Transketolase, thiamine diphosphate binding domain
THETHE_RS10495	COG0860	N-Acetylmuramoyl-L-alanine amidase
THETHE_RS10505	COG4608	Belongs to the ABC transporter superfamily
THETHE_RS10510	COG0444	Belongs to the ABC transporter superfamily
THETHE_RS10515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THETHE_RS10520	COG0601	transmembrane transport
THETHE_RS10525	COG4166	transmembrane transport
THETHE_RS10530	COG4166	transmembrane transport
THETHE_RS10535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THETHE_RS10540	COG0154	amidase activity
THETHE_RS10550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THETHE_RS10560	COG4496	protein, YerC YecD
THETHE_RS10565	COG1447	Phosphotransferase system cellobiose-specific component IIA
THETHE_RS10570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THETHE_RS10585	COG3711	transcriptional antiterminator
THETHE_RS10590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
THETHE_RS10595	COG2011	ABC-type metal ion transport system permease component
THETHE_RS10605	COG2244	polysaccharide biosynthetic process
THETHE_RS10625	COG1473	amidohydrolase
THETHE_RS10635	COG0151	Belongs to the GarS family
THETHE_RS10640	COG0138	bifunctional purine biosynthesis protein purh
THETHE_RS10645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THETHE_RS10650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THETHE_RS10655	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THETHE_RS10660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THETHE_RS10665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THETHE_RS10670	COG2252	PERMEase
THETHE_RS10675	COG0519	Catalyzes the synthesis of GMP from XMP
THETHE_RS10675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THETHE_RS10680	COG0516	GMP reductase activity
THETHE_RS10680	COG0517	IMP dehydrogenase activity
THETHE_RS10710	COG1404	Belongs to the peptidase S8 family
THETHE_RS10720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
THETHE_RS10725	COG4120	Belongs to the binding-protein-dependent transport system permease family
THETHE_RS10750	COG0411	ABC transporter
THETHE_RS10765	COG1132	(ABC) transporter
THETHE_RS10790	COG1811	Na channel or pump
THETHE_RS10815	COG1914	H( )-stimulated, divalent metal cation uptake system
THETHE_RS10825	COG1360	Flagellar Motor Protein
THETHE_RS10835	COG0488	(ABC) transporter
THETHE_RS10845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THETHE_RS10850	COG0456	acetyltransferase
THETHE_RS10855	COG1214	PFAM Peptidase M22, glycoprotease
THETHE_RS10860	COG0802	atpase or kinase
THETHE_RS10875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THETHE_RS10885	COG0398	Pfam SNARE associated Golgi protein
THETHE_RS10890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THETHE_RS10895	COG2183	response to ionizing radiation
THETHE_RS10900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THETHE_RS10905	COG0653	protein targeting
THETHE_RS10915	COG1827	regulation of RNA biosynthetic process
THETHE_RS10940	COG1126	abc transporter atp-binding protein
THETHE_RS10945	COG0765	amino acid transport
THETHE_RS10950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THETHE_RS10965	COG1516	flagellar protein fliS
THETHE_RS10970	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THETHE_RS11005	COG0463	Glycosyl transferase, family 2
THETHE_RS11005	COG0457	Tetratricopeptide repeat
THETHE_RS11010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THETHE_RS11015	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THETHE_RS11020	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
THETHE_RS11030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THETHE_RS11035	COG4786	Flagellar basal body rod
THETHE_RS11035	COG1256	bacterial-type flagellum assembly
THETHE_RS11055	COG1040	competence protein
THETHE_RS11060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THETHE_RS11070	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THETHE_RS11070	COG2199	diguanylate cyclase activity
THETHE_RS11075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THETHE_RS11080	COG1592	Rubrerythrin
THETHE_RS11120	COG3344	reverse transcriptase
THETHE_RS11130	COG5002	protein histidine kinase activity
THETHE_RS11135	COG0745	RESPONSE REGULATOR receiver
THETHE_RS11140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
THETHE_RS11145	COG1609	Transcriptional regulator
THETHE_RS11150	COG0561	phosphatase activity
THETHE_RS11155	COG2323	membrane
THETHE_RS11215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THETHE_RS11225	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THETHE_RS11230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THETHE_RS11235	COG3711	transcriptional antiterminator
THETHE_RS11240	COG2190	(PTS) system
THETHE_RS11245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THETHE_RS11245	COG1263	PTS System
THETHE_RS11255	COG0840	transmembrane signaling receptor activity
THETHE_RS11275	COG2188	Transcriptional regulator
THETHE_RS11280	COG1079	Belongs to the binding-protein-dependent transport system permease family
THETHE_RS11285	COG4603	Belongs to the binding-protein-dependent transport system permease family
THETHE_RS11290	COG3845	ABC transporter
THETHE_RS11295	COG1744	ABC transporter substrate-binding protein PnrA-like
THETHE_RS11300	COG3404	Formiminotransferase-cyclodeaminase
THETHE_RS11350	COG0484	heat shock protein binding
THETHE_RS11380	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
THETHE_RS11385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THETHE_RS11410	COG1797	cobyrinic acid a,c-diamide synthase activity
THETHE_RS11415	COG1120	ATPase activity
THETHE_RS11420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THETHE_RS11425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THETHE_RS11445	COG5464	transposase or invertase
THETHE_RS11480	COG1131	(ABC) transporter
THETHE_RS11505	COG1131	(ABC) transporter
THETHE_RS11525	COG1136	(ABC) transporter
THETHE_RS11525	COG0577	efflux transmembrane transporter activity
THETHE_RS11555	COG0531	amino acid
THETHE_RS11560	COG0116	Belongs to the methyltransferase superfamily
THETHE_RS11565	COG2226	methyltransferase
THETHE_RS11575	COG1522	sequence-specific DNA binding
THETHE_RS11580	COG0436	Aminotransferase
THETHE_RS11595	COG0671	phosphoesterase, PA-phosphatase related
THETHE_RS11605	COG0803	Belongs to the bacterial solute-binding protein 9 family
THETHE_RS11610	COG1121	(ABC) transporter
THETHE_RS11615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THETHE_RS11645	COG0730	response to heat
THETHE_RS11650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THETHE_RS11655	COG0737	Belongs to the 5'-nucleotidase family
THETHE_RS11670	COG1263	PTS System
THETHE_RS11670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THETHE_RS11680	COG1737	Transcriptional regulator
THETHE_RS11690	COG1486	melibiose metabolic process
THETHE_RS11695	COG0673	inositol 2-dehydrogenase activity
THETHE_RS11710	COG1447	Phosphotransferase system cellobiose-specific component IIA
THETHE_RS11720	COG2723	6-phospho-beta-galactosidase activity
THETHE_RS11730	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THETHE_RS11730	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THETHE_RS11735	COG0531	amino acid
THETHE_RS11740	COG4166	transmembrane transport
THETHE_RS11770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
THETHE_RS11775	COG0495	leucyl-tRNA aminoacylation
THETHE_RS11795	COG0436	Aminotransferase
THETHE_RS11800	COG4214	carbohydrate transport
THETHE_RS11810	COG4213	ABC transporter substrate-binding protein
THETHE_RS11815	COG4213	ABC transporter substrate-binding protein
THETHE_RS11820	COG2207	Transcriptional regulator
THETHE_RS11820	COG4753	response regulator
THETHE_RS11825	COG3275	phosphorelay sensor kinase activity
THETHE_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
THETHE_RS11845	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
THETHE_RS11850	COG1609	Transcriptional regulator
THETHE_RS11855	COG0246	Mannitol dehydrogenase
THETHE_RS11860	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THETHE_RS11865	COG1070	Carbohydrate kinase
THETHE_RS11870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THETHE_RS11880	COG1349	DNA-binding transcription factor activity
THETHE_RS11890	COG0534	Mate efflux family protein
THETHE_RS11895	COG2721	sulfolactate sulfo-lyase activity
THETHE_RS11900	COG0246	Mannitol dehydrogenase
THETHE_RS11905	COG1486	melibiose metabolic process
THETHE_RS11915	COG0395	ABC-type sugar transport system, permease component
THETHE_RS11920	COG1175	transmembrane transport
THETHE_RS11930	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
THETHE_RS11935	COG1609	Transcriptional regulator
THETHE_RS11940	COG1904	glucuronate isomerase
THETHE_RS11945	COG0791	NLP P60 protein
THETHE_RS11945	COG1388	LysM domain
THETHE_RS11955	COG0493	'glutamate synthase
THETHE_RS11970	COG0039	L-malate dehydrogenase activity
THETHE_RS12000	COG0586	Pfam SNARE associated Golgi protein
THETHE_RS12005	COG0297	glycogen (starch) synthase activity
THETHE_RS12015	COG1085	galactose-1-phosphate uridylyltransferase
THETHE_RS12040	COG2723	6-phospho-beta-galactosidase activity
THETHE_RS12050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THETHE_RS12060	COG1447	Phosphotransferase system cellobiose-specific component IIA
THETHE_RS12065	COG3711	transcriptional antiterminator
THETHE_RS12065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THETHE_RS12075	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THETHE_RS12080	COG2723	6-phospho-beta-galactosidase activity
THETHE_RS12090	COG1447	Phosphotransferase system cellobiose-specific component IIA
THETHE_RS12095	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THETHE_RS12095	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THETHE_RS12110	COG4716	Myosin-crossreactive antigen
THETHE_RS12120	COG3875	lactate racemase activity
THETHE_RS12125	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THETHE_RS12135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THETHE_RS12140	COG2161	toxin-antitoxin pair type II binding
THETHE_RS12160	COG0534	Mate efflux family protein
THETHE_RS12165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THETHE_RS12175	COG2217	Heavy metal translocating P-type atpase
THETHE_RS12185	COG1309	transcriptional regulator
THETHE_RS12200	COG1131	(ABC) transporter
THETHE_RS12215	COG0864	Transcriptional regulator
THETHE_RS12220	COG0310	cobalt ion transport
THETHE_RS12225	COG0310	cobalt ion transport
THETHE_RS12235	COG1122	ATPase activity
THETHE_RS12255	COG1595	DNA-templated transcription, initiation
THETHE_RS12265	COG0205	6-phosphofructokinase activity
THETHE_RS12275	COG3958	Transketolase
THETHE_RS12280	COG3959	Transketolase, thiamine diphosphate binding domain
THETHE_RS12295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THETHE_RS12300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THETHE_RS12305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THETHE_RS12315	COG1609	Transcriptional regulator
THETHE_RS12320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THETHE_RS12335	COG1070	Carbohydrate kinase
THETHE_RS12340	COG2115	Belongs to the xylose isomerase family
THETHE_RS12345	COG3973	AAA domain
THETHE_RS12355	COG2267	carboxylic ester hydrolase activity
THETHE_RS12360	COG0446	pyridine nucleotide-disulphide oxidoreductase
THETHE_RS12360	COG1902	pentaerythritol trinitrate reductase activity
THETHE_RS12365	COG0583	DNA-binding transcription factor activity
THETHE_RS12380	COG5434	Belongs to the glycosyl hydrolase 28 family
THETHE_RS12380	COG4632	Exopolysaccharide biosynthesis protein
THETHE_RS12385	COG1979	alcohol dehydrogenase
THETHE_RS12395	COG0463	Glycosyl transferase, family 2
THETHE_RS12395	COG0457	Tetratricopeptide repeat
THETHE_RS12400	COG0840	transmembrane signaling receptor activity
THETHE_RS12405	COG1496	oxidoreductase activity
THETHE_RS12420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THETHE_RS12425	COG1132	(ABC) transporter
THETHE_RS12430	COG1132	(ABC) transporter
THETHE_RS12445	COG4786	Flagellar basal body rod
THETHE_RS12455	COG1609	Transcriptional regulator
THETHE_RS12465	COG2385	sporulation resulting in formation of a cellular spore
THETHE_RS12500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THETHE_RS12505	COG0531	amino acid
THETHE_RS12515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THETHE_RS12525	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THETHE_RS12530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THETHE_RS12545	COG0698	ribose 5-phosphate isomerase
THETHE_RS12550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THETHE_RS12555	COG0009	L-threonylcarbamoyladenylate synthase
THETHE_RS12565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THETHE_RS12570	COG2890	protein-(glutamine-N5) methyltransferase activity
THETHE_RS12575	COG3872	metal-dependent enzyme
THETHE_RS12585	COG0254	rRNA binding
THETHE_RS12590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THETHE_RS12605	COG0745	RESPONSE REGULATOR receiver
THETHE_RS12610	COG0860	N-Acetylmuramoyl-L-alanine amidase
THETHE_RS12610	COG2247	cell wall binding repeat
THETHE_RS12615	COG3344	reverse transcriptase
THETHE_RS12625	COG0577	efflux transmembrane transporter activity
THETHE_RS12625	COG1136	(ABC) transporter
THETHE_RS12630	COG1136	(ABC) transporter
THETHE_RS12640	COG1132	(ABC) transporter
THETHE_RS12645	COG1132	(ABC) transporter
THETHE_RS12665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THETHE_RS12665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THETHE_RS12665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THETHE_RS12670	COG1105	Belongs to the carbohydrate kinase PfkB family
THETHE_RS12675	COG1349	DNA-binding transcription factor activity
THETHE_RS12700	COG1216	Glycosyl transferase, family 2
THETHE_RS12710	COG0463	Glycosyl transferase, family 2
THETHE_RS12715	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THETHE_RS12735	COG2770	Histidine kinase
THETHE_RS12735	COG2205	protein histidine kinase activity
THETHE_RS12740	COG0745	RESPONSE REGULATOR receiver
THETHE_RS12745	COG2373	Large extracellular alpha-helical protein
THETHE_RS12775	COG0504	CTP synthase activity
THETHE_RS12780	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THETHE_RS12805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THETHE_RS12810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THETHE_RS12815	COG1929	Belongs to the glycerate kinase type-1 family
THETHE_RS12820	COG3409	Peptidoglycan-binding domain 1 protein
THETHE_RS12820	COG0793	Belongs to the peptidase S41A family
THETHE_RS12825	COG0083	homoserine kinase activity
THETHE_RS12830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THETHE_RS12835	COG0460	homoserine dehydrogenase
THETHE_RS12850	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
THETHE_RS12855	COG0674	pyruvate-flavodoxin oxidoreductase activity
THETHE_RS12855	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THETHE_RS12860	COG1013	pyruvate-flavodoxin oxidoreductase activity
THETHE_RS12865	COG1132	(ABC) transporter
THETHE_RS12875	COG1846	Transcriptional regulator
THETHE_RS12900	COG1732	Glycine betaine
THETHE_RS12905	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THETHE_RS12910	COG1518	maintenance of DNA repeat elements
THETHE_RS12965	COG1337	RAMP superfamily
THETHE_RS13000	COG0822	iron-sulfur transferase activity
THETHE_RS13005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THETHE_RS13010	COG0719	Fe-S assembly protein
THETHE_RS13015	COG0719	Fe-S assembly protein
THETHE_RS13020	COG0396	ATPase activity
THETHE_RS13055	COG1454	alcohol dehydrogenase
THETHE_RS13055	COG1012	belongs to the aldehyde dehydrogenase family
THETHE_RS13065	COG0667	Aldo Keto reductase
THETHE_RS13070	COG2211	Major facilitator Superfamily
THETHE_RS13080	COG3344	reverse transcriptase
THETHE_RS13100	COG1924	4 iron, 4 sulfur cluster binding
THETHE_RS13135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THETHE_RS13160	COG2203	Gaf domain
THETHE_RS13160	COG2199	diguanylate cyclase activity
THETHE_RS13165	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THETHE_RS13170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THETHE_RS13175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THETHE_RS13195	COG5002	protein histidine kinase activity
THETHE_RS13200	COG0745	RESPONSE REGULATOR receiver
THETHE_RS13210	COG0739	heme binding
THETHE_RS13255	COG3464	Transposase
THETHE_RS13285	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
THETHE_RS13310	COG5002	protein histidine kinase activity
THETHE_RS13310	COG3850	Histidine kinase
THETHE_RS13315	COG0745	RESPONSE REGULATOR receiver
THETHE_RS13325	COG2239	Acts as a magnesium transporter
THETHE_RS13335	COG0305	Participates in initiation and elongation during chromosome replication
THETHE_RS13345	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
THETHE_RS13365	COG0629	single-stranded DNA binding
THETHE_RS13370	COG0360	Binds together with S18 to 16S ribosomal RNA
THETHE_RS13375	COG4481	Protein conserved in bacteria
THETHE_RS13380	COG0668	transmembrane transport
THETHE_RS13395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THETHE_RS13395	COG0189	ligase activity
THETHE_RS13405	COG1597	lipid kinase activity
THETHE_RS13415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THETHE_RS13420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THETHE_RS13425	COG1475	DNA binding
THETHE_RS13430	COG1192	Involved in chromosome partitioning
THETHE_RS13435	COG1475	DNA binding
THETHE_RS13445	COG0357	Ribosomal RNA small subunit methyltransferase G
THETHE_RS13455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THETHE_RS13460	COG1847	R3H domain protein
THETHE_RS13465	COG0706	membrane insertase activity
THETHE_RS14215	COG2333	competence protein COMEC
THETHE_RS14215	COG0658	competence protein