locus-tag	class	description
THEXY_RS00015	COG0592	DNA-directed DNA polymerase activity
THEXY_RS00020	COG2501	S4 domain
THEXY_RS00035	COG3442	glutamine amidotransferase
THEXY_RS00045	COG0187	DNA topoisomerase II activity
THEXY_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THEXY_RS00065	COG0440	acetolactate synthase activity
THEXY_RS00075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEXY_RS00085	COG0066	3-isopropylmalate dehydratase activity
THEXY_RS00090	COG0473	3-isopropylmalate dehydrogenase activity
THEXY_RS00095	COG0129	dihydroxy-acid dehydratase activity
THEXY_RS00100	COG0028	Belongs to the TPP enzyme family
THEXY_RS00125	COG0628	permease
THEXY_RS00130	COG0681	Belongs to the peptidase S26 family
THEXY_RS00150	COG1316	TRANSCRIPTIONal
THEXY_RS00155	COG1615	UPF0182 protein
THEXY_RS00175	COG3706	GGDEF domain
THEXY_RS00185	COG0582	viral genome integration into host DNA
THEXY_RS00190	COG3290	protein histidine kinase activity
THEXY_RS00190	COG0840	transmembrane signaling receptor activity
THEXY_RS00195	COG0835	chemotaxis
THEXY_RS00200	COG2201	protein-glutamate methylesterase activity
THEXY_RS00210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THEXY_RS00215	COG5001	Diguanylate cyclase
THEXY_RS00215	COG3300	MHYT domain
THEXY_RS00225	COG3344	reverse transcriptase
THEXY_RS00240	COG0590	tRNA wobble adenosine to inosine editing
THEXY_RS00255	COG2199	diguanylate cyclase activity
THEXY_RS00255	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEXY_RS00260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THEXY_RS00265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THEXY_RS00270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THEXY_RS00275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THEXY_RS00285	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEXY_RS00335	COG1028	Short-chain dehydrogenase reductase Sdr
THEXY_RS00340	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THEXY_RS00355	COG1187	pseudouridine synthase activity
THEXY_RS00360	COG1882	Formate acetyltransferase
THEXY_RS00365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
THEXY_RS00375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEXY_RS00380	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
THEXY_RS00390	COG1573	uracil-dna glycosylase
THEXY_RS00415	COG0519	Catalyzes the synthesis of GMP from XMP
THEXY_RS00425	COG1982	Orn Lys Arg decarboxylase major
THEXY_RS00435	COG3870	Protein conserved in bacteria
THEXY_RS00445	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THEXY_RS00450	COG1774	PSP1 C-terminal conserved region
THEXY_RS00460	COG0730	response to heat
THEXY_RS00470	COG2235	arginine
THEXY_RS00475	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
THEXY_RS00480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THEXY_RS00485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THEXY_RS00490	COG2002	toxin-antitoxin pair type II binding
THEXY_RS00495	COG2715	membrane protein required for spore maturation
THEXY_RS00500	COG0700	Nucleoside recognition
THEXY_RS00505	COG0617	tRNA 3'-terminal CCA addition
THEXY_RS00510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEXY_RS00510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEXY_RS00515	COG1725	Transcriptional regulator
THEXY_RS00520	COG1131	(ABC) transporter
THEXY_RS00540	COG0084	hydrolase, TatD family'
THEXY_RS00550	COG3584	3D domain protein
THEXY_RS00550	COG3583	domain protein
THEXY_RS00555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THEXY_RS00570	COG0489	protein tyrosine kinase activity
THEXY_RS00590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THEXY_RS00590	COG2111	Na H antiporter
THEXY_RS00600	COG3260	NADH ubiquinone oxidoreductase 20
THEXY_RS00615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEXY_RS00620	COG0375	protein maturation
THEXY_RS00630	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THEXY_RS00635	COG0298	carbon dioxide binding
THEXY_RS00670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THEXY_RS00745	COG0789	Transcriptional regulator
THEXY_RS00750	COG1664	Polymer-forming cytoskeletal
THEXY_RS00760	COG0071	Belongs to the small heat shock protein (HSP20) family
THEXY_RS00770	COG1609	Transcriptional regulator
THEXY_RS00775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THEXY_RS00780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THEXY_RS00790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THEXY_RS00795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THEXY_RS00805	COG3850	Histidine kinase
THEXY_RS00805	COG5002	protein histidine kinase activity
THEXY_RS00810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEXY_RS00825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THEXY_RS00830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THEXY_RS00835	COG2002	toxin-antitoxin pair type II binding
THEXY_RS00845	COG4466	Protein conserved in bacteria
THEXY_RS00855	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THEXY_RS00860	COG1802	Transcriptional regulator
THEXY_RS00875	COG0697	spore germination
THEXY_RS00880	COG0531	amino acid
THEXY_RS00895	COG1982	Orn Lys Arg decarboxylase major
THEXY_RS00905	COG2959	enzyme of heme biosynthesis
THEXY_RS00915	COG1438	arginine binding
THEXY_RS00920	COG0531	amino acid
THEXY_RS00925	COG2235	arginine
THEXY_RS00945	COG1438	arginine binding
THEXY_RS00960	COG0018	arginyl-trna synthetase
THEXY_RS00965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THEXY_RS00980	COG0531	amino acid
THEXY_RS00990	COG0667	Aldo Keto reductase
THEXY_RS01000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THEXY_RS01005	COG3859	Proton-coupled thiamine transporter YuaJ
THEXY_RS01010	COG3344	reverse transcriptase
THEXY_RS01015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THEXY_RS01020	COG0671	phosphoesterase, PA-phosphatase related
THEXY_RS01035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THEXY_RS01075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THEXY_RS01080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THEXY_RS01090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THEXY_RS01095	COG0505	Belongs to the CarA family
THEXY_RS01110	COG0165	Argininosuccinate lyase
THEXY_RS01120	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEXY_RS01125	COG0586	Pfam SNARE associated Golgi protein
THEXY_RS01130	COG1321	iron dependent repressor
THEXY_RS01135	COG1914	H( )-stimulated, divalent metal cation uptake system
THEXY_RS01140	COG2033	superoxide reductase activity
THEXY_RS01145	COG1027	Aspartate ammonia-lyase
THEXY_RS01165	COG3956	TIGRFAM MazG family protein
THEXY_RS01170	COG0776	regulation of translation
THEXY_RS01175	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THEXY_RS01180	COG2385	sporulation resulting in formation of a cellular spore
THEXY_RS01210	COG1098	S1 RNA binding domain
THEXY_RS01215	COG0248	Ppx GppA phosphatase
THEXY_RS01235	COG3344	reverse transcriptase
THEXY_RS01255	COG0860	N-Acetylmuramoyl-L-alanine amidase
THEXY_RS01265	COG2233	PERMEase
THEXY_RS01280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THEXY_RS01280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THEXY_RS01280	COG0674	pyruvate-flavodoxin oxidoreductase activity
THEXY_RS01280	COG1013	pyruvate-flavodoxin oxidoreductase activity
THEXY_RS01310	COG2226	methyltransferase
THEXY_RS01335	COG2226	methyltransferase
THEXY_RS01345	COG2208	phosphoserine phosphatase activity
THEXY_RS01355	COG2815	serine threonine protein kinase
THEXY_RS01355	COG0515	serine threonine protein kinase
THEXY_RS01360	COG0037	tRNA processing
THEXY_RS01365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THEXY_RS01365	COG0037	tRNA processing
THEXY_RS01375	COG4977	sequence-specific DNA binding
THEXY_RS01375	COG1917	Cupin 2, conserved barrel domain protein
THEXY_RS01385	COG4191	Histidine kinase
THEXY_RS01390	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THEXY_RS01400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THEXY_RS01410	COG4684	Psort location CytoplasmicMembrane, score
THEXY_RS01425	COG0697	spore germination
THEXY_RS01450	COG5322	oxidoreductase activity
THEXY_RS01450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THEXY_RS01460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THEXY_RS01470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THEXY_RS01475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THEXY_RS01480	COG0720	synthase
THEXY_RS01490	COG4224	UPF0291 protein
THEXY_RS01510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THEXY_RS01520	COG3711	transcriptional antiterminator
THEXY_RS01520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEXY_RS01525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEXY_RS01525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEXY_RS01525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEXY_RS01530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEXY_RS01530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEXY_RS01530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEXY_RS01535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEXY_RS01540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEXY_RS01545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THEXY_RS01550	COG0281	malic enzyme
THEXY_RS01565	COG3880	PFAM UvrB UvrC protein
THEXY_RS01570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
THEXY_RS01575	COG0542	response to heat
THEXY_RS01580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THEXY_RS01590	COG4956	integral membrane protein (PIN domain superfamily)
THEXY_RS01595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THEXY_RS01605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THEXY_RS01620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THEXY_RS01625	COG1045	serine acetyltransferase
THEXY_RS01645	COG3688	RNA-binding protein containing a PIN domain
THEXY_RS01650	COG1595	DNA-templated transcription, initiation
THEXY_RS01660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THEXY_RS01665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THEXY_RS01670	COG0250	Participates in transcription elongation, termination and antitermination
THEXY_RS01690	COG0222	ribosome binding
THEXY_RS01695	COG0085	RNA polymerase activity
THEXY_RS01700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THEXY_RS01705	COG1358	cellular component organization or biogenesis
THEXY_RS01710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THEXY_RS01715	COG0049	tRNA binding
THEXY_RS01725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THEXY_RS01735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THEXY_RS01760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THEXY_RS01765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THEXY_RS01770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THEXY_RS01800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THEXY_RS01820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THEXY_RS01825	COG1841	ribosomal large subunit assembly
THEXY_RS01830	COG0200	Binds to the 23S rRNA
THEXY_RS01835	COG0201	protein transport
THEXY_RS01855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THEXY_RS01860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THEXY_RS01870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THEXY_RS01890	COG1122	ATPase activity
THEXY_RS01895	COG1122	ATPase activity
THEXY_RS01900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THEXY_RS01910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THEXY_RS01975	COG1454	alcohol dehydrogenase
THEXY_RS01990	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THEXY_RS02015	COG3942	CHAP domain
THEXY_RS02015	COG1388	LysM domain
THEXY_RS02025	COG0714	Associated with various cellular activities
THEXY_RS02035	COG1305	Transglutaminase-like
THEXY_RS02045	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
THEXY_RS02095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THEXY_RS02140	COG0454	-acetyltransferase
THEXY_RS02145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
THEXY_RS02150	COG0456	acetyltransferase
THEXY_RS02160	COG0561	phosphatase activity
THEXY_RS02165	COG2703	oxygen carrier activity
THEXY_RS02180	COG3973	AAA domain
THEXY_RS02185	COG0432	Pfam Uncharacterised protein family UPF0047
THEXY_RS02200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THEXY_RS02200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THEXY_RS02210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THEXY_RS02220	COG2337	Toxic component of a toxin-antitoxin (TA) module
THEXY_RS02240	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
THEXY_RS02245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THEXY_RS02270	COG3464	Transposase
THEXY_RS02275	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THEXY_RS02280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
THEXY_RS02285	COG0157	Belongs to the NadC ModD family
THEXY_RS02295	COG1773	rubredoxin
THEXY_RS02305	COG0673	inositol 2-dehydrogenase activity
THEXY_RS02325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THEXY_RS02325	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
THEXY_RS02335	COG3459	Glycosyltransferase 36 associated
THEXY_RS02340	COG1725	Transcriptional regulator
THEXY_RS02350	COG0330	HflC and HflK could
THEXY_RS02360	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THEXY_RS02370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THEXY_RS02375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THEXY_RS02380	COG0131	Imidazoleglycerol-phosphate dehydratase
THEXY_RS02385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THEXY_RS02400	COG0140	phosphoribosyl-ATP diphosphatase activity
THEXY_RS02400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THEXY_RS02405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THEXY_RS02420	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THEXY_RS02430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THEXY_RS02455	COG0640	Transcriptional regulator
THEXY_RS02480	COG2814	Major facilitator Superfamily
THEXY_RS02500	COG1924	4 iron, 4 sulfur cluster binding
THEXY_RS02505	COG1230	cation diffusion facilitator family transporter
THEXY_RS02515	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THEXY_RS02525	COG0798	PFAM Bile acid sodium symporter
THEXY_RS02540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THEXY_RS02545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
THEXY_RS02550	COG0579	oxidoreductase
THEXY_RS02555	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEXY_RS02565	COG3290	protein histidine kinase activity
THEXY_RS02565	COG3829	transcription factor binding
THEXY_RS02570	COG2376	Dihydroxyacetone kinase
THEXY_RS02580	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
THEXY_RS02590	COG0443	Heat shock 70 kDa protein
THEXY_RS02625	COG0849	cell division
THEXY_RS02645	COG1131	(ABC) transporter
THEXY_RS02660	COG1598	PFAM Uncharacterised protein family UPF0150
THEXY_RS02685	COG3842	ATPase activity
THEXY_RS02695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THEXY_RS02700	COG0437	4 iron, 4 sulfur cluster binding
THEXY_RS02710	COG0067	glutamate synthase
THEXY_RS02715	COG3835	regulator
THEXY_RS02720	COG2884	Cell division ATP-binding protein ftsE
THEXY_RS02725	COG2177	Part of the ABC transporter FtsEX involved in
THEXY_RS02730	COG0739	heme binding
THEXY_RS02735	COG0793	Belongs to the peptidase S41A family
THEXY_RS02740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEXY_RS02745	COG2045	Belongs to the ComB family
THEXY_RS02750	COG0556	nucleotide-excision repair
THEXY_RS02760	COG1716	ATPase activity
THEXY_RS02770	COG0768	penicillin binding
THEXY_RS02785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THEXY_RS02795	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THEXY_RS02795	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THEXY_RS02815	COG0318	PFAM AMP-dependent synthetase and ligase
THEXY_RS02825	COG0673	inositol 2-dehydrogenase activity
THEXY_RS02840	COG0673	inositol 2-dehydrogenase activity
THEXY_RS02845	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEXY_RS02845	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEXY_RS02850	COG1447	Phosphotransferase system cellobiose-specific component IIA
THEXY_RS02855	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
THEXY_RS02875	COG2723	6-phospho-beta-galactosidase activity
THEXY_RS02880	COG3534	alpha-L-arabinofuranosidase
THEXY_RS02895	COG1129	ABC transporter
THEXY_RS02900	COG1172	Belongs to the binding-protein-dependent transport system permease family
THEXY_RS02905	COG2160	L-arabinose isomerase activity
THEXY_RS02910	COG1069	ribulokinase activity
THEXY_RS02915	COG0235	Class ii aldolase
THEXY_RS02925	COG1609	Transcriptional regulator
THEXY_RS02930	COG0371	Dehydrogenase
THEXY_RS02935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THEXY_RS02970	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
THEXY_RS02975	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THEXY_RS02980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THEXY_RS02985	COG1940	carbohydrate kinase activity
THEXY_RS03015	COG1477	protein flavinylation
THEXY_RS03025	COG0768	penicillin binding
THEXY_RS03030	COG1793	dna ligase
THEXY_RS03030	COG3285	dna ligase
THEXY_RS03035	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
THEXY_RS03045	COG1388	LysM domain
THEXY_RS03045	COG0791	NLP P60 protein
THEXY_RS03065	COG2755	lipolytic protein G-D-S-L family
THEXY_RS03065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
THEXY_RS03070	COG0531	amino acid
THEXY_RS03075	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
THEXY_RS03085	COG2608	mercury ion transmembrane transporter activity
THEXY_RS03095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THEXY_RS03110	COG0589	response to stress
THEXY_RS03140	COG2211	Major facilitator Superfamily
THEXY_RS03145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THEXY_RS03145	COG1796	DNA polymerase
THEXY_RS03150	COG2873	o-acetylhomoserine
THEXY_RS03155	COG1914	H( )-stimulated, divalent metal cation uptake system
THEXY_RS03170	COG2217	Heavy metal translocating P-type atpase
THEXY_RS03175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THEXY_RS03180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THEXY_RS03185	COG1660	Displays ATPase and GTPase activities
THEXY_RS03220	COG0840	transmembrane signaling receptor activity
THEXY_RS03230	COG1175	transmembrane transport
THEXY_RS03235	COG3833	ABC-type maltose transport systems, permease component
THEXY_RS03250	COG1426	Protein conserved in bacteria
THEXY_RS03255	COG0366	Alpha amylase catalytic
THEXY_RS03270	COG1481	regulation of sporulation
THEXY_RS03275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEXY_RS03280	COG4109	DRTGG domain
THEXY_RS03315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THEXY_RS03350	COG3547	Transposase (IS116 IS110 IS902 family)
THEXY_RS03370	COG3464	Transposase
THEXY_RS03375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THEXY_RS03380	COG0765	amino acid transport
THEXY_RS03410	COG1827	regulation of RNA biosynthetic process
THEXY_RS03420	COG0653	protein targeting
THEXY_RS03425	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THEXY_RS03430	COG2183	response to ionizing radiation
THEXY_RS03435	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THEXY_RS03440	COG0398	Pfam SNARE associated Golgi protein
THEXY_RS03445	COG3464	Transposase
THEXY_RS03450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THEXY_RS03455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THEXY_RS03470	COG0802	atpase or kinase
THEXY_RS03475	COG1214	PFAM Peptidase M22, glycoprotease
THEXY_RS03480	COG0456	acetyltransferase
THEXY_RS03485	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THEXY_RS03490	COG0488	(ABC) transporter
THEXY_RS03500	COG1360	Flagellar Motor Protein
THEXY_RS03510	COG1914	H( )-stimulated, divalent metal cation uptake system
THEXY_RS03525	COG1811	Na channel or pump
THEXY_RS03535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THEXY_RS03595	COG4120	Belongs to the binding-protein-dependent transport system permease family
THEXY_RS03600	COG1136	(ABC) transporter
THEXY_RS03610	COG1404	Belongs to the peptidase S8 family
THEXY_RS03640	COG0516	GMP reductase activity
THEXY_RS03640	COG0517	IMP dehydrogenase activity
THEXY_RS03645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THEXY_RS03645	COG0519	Catalyzes the synthesis of GMP from XMP
THEXY_RS03650	COG2252	PERMEase
THEXY_RS03655	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THEXY_RS03660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THEXY_RS03665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THEXY_RS03670	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THEXY_RS03680	COG0138	bifunctional purine biosynthesis protein purh
THEXY_RS03685	COG0151	Belongs to the GarS family
THEXY_RS03690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THEXY_RS03695	COG1473	amidohydrolase
THEXY_RS03705	COG1854	S-ribosylhomocysteine lyase activity
THEXY_RS03720	COG2011	ABC-type metal ion transport system permease component
THEXY_RS03725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
THEXY_RS03730	COG3711	transcriptional antiterminator
THEXY_RS03745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THEXY_RS03750	COG1447	Phosphotransferase system cellobiose-specific component IIA
THEXY_RS03755	COG4496	protein, YerC YecD
THEXY_RS03775	COG0154	amidase activity
THEXY_RS03780	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THEXY_RS03785	COG4166	transmembrane transport
THEXY_RS03790	COG4166	transmembrane transport
THEXY_RS03795	COG0601	transmembrane transport
THEXY_RS03800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THEXY_RS03805	COG0444	Belongs to the ABC transporter superfamily
THEXY_RS03810	COG4608	Belongs to the ABC transporter superfamily
THEXY_RS03815	COG0860	N-Acetylmuramoyl-L-alanine amidase
THEXY_RS03910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THEXY_RS03980	COG0457	Tetratricopeptide repeat
THEXY_RS03980	COG0463	Glycosyl transferase, family 2
THEXY_RS03990	COG1309	transcriptional regulator
THEXY_RS03995	COG1511	domain protein
THEXY_RS04015	COG0778	Nitroreductase
THEXY_RS04025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEXY_RS04035	COG1074	ATP-dependent DNA helicase activity
THEXY_RS04040	COG2309	aminopeptidase activity
THEXY_RS04050	COG0564	pseudouridine synthase activity
THEXY_RS04095	COG1592	Rubrerythrin
THEXY_RS04095	COG1773	rubredoxin
THEXY_RS04100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THEXY_RS04105	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEXY_RS04105	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEXY_RS04120	COG3716	PTS system mannose fructose sorbose family IID component
THEXY_RS04125	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THEXY_RS04130	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THEXY_RS04160	COG1067	ATP-dependent peptidase activity
THEXY_RS04165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THEXY_RS04175	COG2720	vancomycin resistance protein
THEXY_RS04180	COG0735	belongs to the Fur family
THEXY_RS04185	COG0561	phosphatase activity
THEXY_RS04190	COG1254	Belongs to the acylphosphatase family
THEXY_RS04195	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
THEXY_RS04210	COG0126	phosphoglycerate kinase activity
THEXY_RS04215	COG0149	triose-phosphate isomerase activity
THEXY_RS04220	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THEXY_RS04225	COG0148	phosphopyruvate hydratase activity
THEXY_RS04235	COG1342	Belongs to the UPF0251 family
THEXY_RS04240	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THEXY_RS04245	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THEXY_RS04250	COG0358	DNA primase activity
THEXY_RS04255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THEXY_RS04270	COG2384	SAM-dependent methyltransferase
THEXY_RS04275	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THEXY_RS04280	COG0482	sulfurtransferase activity
THEXY_RS04290	COG1482	cell wall glycoprotein biosynthetic process
THEXY_RS04340	COG1704	LemA family
THEXY_RS04350	COG1902	pentaerythritol trinitrate reductase activity
THEXY_RS04355	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
THEXY_RS04370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THEXY_RS04375	COG1278	Cold shock
THEXY_RS04410	COG0006	proline dipeptidase activity
THEXY_RS04420	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
THEXY_RS04455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THEXY_RS04470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THEXY_RS04480	COG2205	protein histidine kinase activity
THEXY_RS04485	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
THEXY_RS04490	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
THEXY_RS04495	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
THEXY_RS04500	COG5002	protein histidine kinase activity
THEXY_RS04505	COG0745	RESPONSE REGULATOR receiver
THEXY_RS04535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THEXY_RS04540	COG0739	heme binding
THEXY_RS04545	COG0772	Belongs to the SEDS family
THEXY_RS04555	COG1136	(ABC) transporter
THEXY_RS04560	COG0577	efflux transmembrane transporter activity
THEXY_RS04560	COG1136	(ABC) transporter
THEXY_RS04575	COG0242	peptide deformylase activity
THEXY_RS04580	COG0489	protein tyrosine kinase activity
THEXY_RS04610	COG0425	Belongs to the sulfur carrier protein TusA family
THEXY_RS04615	COG2391	methyltransferase activity
THEXY_RS04640	COG0509	glycine decarboxylation via glycine cleavage system
THEXY_RS04645	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THEXY_RS04650	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEXY_RS04655	COG0735	belongs to the Fur family
THEXY_RS04670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THEXY_RS04680	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THEXY_RS04690	COG0489	protein tyrosine kinase activity
THEXY_RS04695	COG2894	cell division
THEXY_RS04705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEXY_RS04715	COG0745	RESPONSE REGULATOR receiver
THEXY_RS04720	COG5002	protein histidine kinase activity
THEXY_RS04730	COG2814	Major facilitator Superfamily
THEXY_RS04735	COG0390	transport system, permease component
THEXY_RS04740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEXY_RS04750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THEXY_RS04765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THEXY_RS04770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THEXY_RS04780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THEXY_RS04795	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THEXY_RS04800	COG0569	domain protein
THEXY_RS04810	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THEXY_RS04815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THEXY_RS04830	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THEXY_RS04835	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THEXY_RS04840	COG2182	Extracellular solute-binding protein
THEXY_RS04855	COG1621	beta-fructofuranosidase activity
THEXY_RS04860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THEXY_RS04865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THEXY_RS04870	COG0366	Alpha amylase catalytic
THEXY_RS04875	COG1609	Transcriptional regulator
THEXY_RS04885	COG2213	PTS system mannitol-specific
THEXY_RS04890	COG3711	transcriptional antiterminator
THEXY_RS04900	COG0246	Mannitol dehydrogenase
THEXY_RS04910	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEXY_RS04910	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEXY_RS04925	COG3414	Phosphotransferase system galactitol-specific IIB component
THEXY_RS04930	COG3775	system Galactitol-specific IIC component
THEXY_RS04935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THEXY_RS04950	COG4948	Mandelate Racemase Muconate Lactonizing
THEXY_RS04955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THEXY_RS04960	COG0800	Aldolase
THEXY_RS04990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEXY_RS05010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THEXY_RS05015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
THEXY_RS05025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THEXY_RS05050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THEXY_RS05075	COG3275	phosphorelay sensor kinase activity
THEXY_RS05080	COG3279	Response regulator of the LytR AlgR family
THEXY_RS05085	COG1966	Carbon starvation protein
THEXY_RS05095	COG1131	(ABC) transporter
THEXY_RS05115	COG5002	protein histidine kinase activity
THEXY_RS05120	COG0697	spore germination
THEXY_RS05125	COG0531	amino acid
THEXY_RS05170	COG3464	Transposase
THEXY_RS05175	COG0352	thiamine-phosphate diphosphorylase activity
THEXY_RS05175	COG0351	phosphomethylpyrimidine kinase
THEXY_RS05190	COG0352	thiamine-phosphate diphosphorylase activity
THEXY_RS05195	COG1533	DNA photolyase activity
THEXY_RS05210	COG0004	ammonium transporteR
THEXY_RS05220	COG0004	ammonium transporteR
THEXY_RS05225	COG0347	Belongs to the P(II) protein family
THEXY_RS05235	COG0367	asparagine synthase
THEXY_RS05245	COG0745	RESPONSE REGULATOR receiver
THEXY_RS05260	COG4399	Belongs to the UPF0754 family
THEXY_RS05265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THEXY_RS05275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THEXY_RS05280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THEXY_RS05285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THEXY_RS05290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THEXY_RS05295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THEXY_RS05300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THEXY_RS05305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEXY_RS05305	COG0072	phenylalanine-tRNA ligase activity
THEXY_RS05315	COG0826	peptidase U32
THEXY_RS05320	COG1193	negative regulation of DNA recombination
THEXY_RS05345	COG2197	response regulator
THEXY_RS05350	COG1362	aminopeptidase activity
THEXY_RS05355	COG2340	Cysteine-rich secretory protein family
THEXY_RS05375	COG3344	reverse transcriptase
THEXY_RS05380	COG0438	transferase activity, transferring glycosyl groups
THEXY_RS05385	COG1937	Protein conserved in bacteria
THEXY_RS05395	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THEXY_RS05420	COG0301	tRNA thio-modification
THEXY_RS05425	COG0012	GTP binding
THEXY_RS05435	COG0612	Peptidase, M16
THEXY_RS05440	COG0612	Peptidase, M16
THEXY_RS05460	COG0768	penicillin binding
THEXY_RS05465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THEXY_RS05470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THEXY_RS05485	COG0772	Belongs to the SEDS family
THEXY_RS05495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THEXY_RS05510	COG3856	small basic protein
THEXY_RS05515	COG0849	cell division
THEXY_RS05520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THEXY_RS05530	COG1191	sigma factor activity
THEXY_RS05535	COG1191	sigma factor activity
THEXY_RS05540	COG1873	PFAM PRC-barrel domain
THEXY_RS05550	COG0745	RESPONSE REGULATOR receiver
THEXY_RS05565	COG0573	inorganic phosphate transmembrane transporter activity
THEXY_RS05570	COG0581	inorganic phosphate transmembrane transporter activity
THEXY_RS05575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THEXY_RS05580	COG0704	Plays a role in the regulation of phosphate uptake
THEXY_RS05625	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
THEXY_RS05645	COG0584	glycerophosphoryl diester phosphodiesterase
THEXY_RS05655	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THEXY_RS05675	COG3069	C4-dicarboxylate transmembrane transporter activity
THEXY_RS05680	COG0426	domain, Protein
THEXY_RS05690	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THEXY_RS05695	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
THEXY_RS05705	COG1164	Oligoendopeptidase f
THEXY_RS05715	COG1760	l-serine dehydratase
THEXY_RS05720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THEXY_RS05725	COG0077	Prephenate dehydratase
THEXY_RS05725	COG1605	Chorismate mutase
THEXY_RS05730	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THEXY_RS05735	COG0287	Prephenate dehydrogenase
THEXY_RS05745	COG0745	RESPONSE REGULATOR receiver
THEXY_RS05750	COG5002	protein histidine kinase activity
THEXY_RS05755	COG3409	Peptidoglycan-binding domain 1 protein
THEXY_RS05755	COG3773	Cell wall hydrolase
THEXY_RS05760	COG2119	membrane
THEXY_RS05785	COG1940	carbohydrate kinase activity
THEXY_RS05790	COG0363	glucosamine-6-phosphate deaminase activity
THEXY_RS05795	COG0785	Cytochrome C biogenesis protein
THEXY_RS05800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THEXY_RS05805	COG3118	belongs to the thioredoxin family
THEXY_RS05810	COG0745	RESPONSE REGULATOR receiver
THEXY_RS05815	COG2205	protein histidine kinase activity
THEXY_RS05825	COG1982	Orn Lys Arg decarboxylase major
THEXY_RS05830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THEXY_RS05835	COG0477	Major facilitator Superfamily
THEXY_RS05840	COG0789	Transcriptional regulator
THEXY_RS05850	COG2078	PFAM AMMECR1 domain protein
THEXY_RS05850	COG3885	ferrous iron binding
THEXY_RS05865	COG0628	permease
THEXY_RS05870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THEXY_RS05875	COG4472	Bacterial protein of unknown function (DUF965)
THEXY_RS05885	COG3906	Belongs to the UPF0473 family
THEXY_RS05890	COG0735	belongs to the Fur family
THEXY_RS05895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
THEXY_RS05900	COG3679	Belongs to the UPF0342 family
THEXY_RS05905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THEXY_RS05910	COG4122	O-methyltransferase activity
THEXY_RS05915	COG0826	peptidase U32
THEXY_RS05920	COG0768	penicillin binding
THEXY_RS05935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THEXY_RS05940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THEXY_RS05950	COG1459	type II secretion system
THEXY_RS05960	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THEXY_RS06010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THEXY_RS06025	COG0006	proline dipeptidase activity
THEXY_RS06040	COG3854	ATPases associated with a variety of cellular activities
THEXY_RS06080	COG1302	Protein conserved in bacteria
THEXY_RS06090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THEXY_RS06095	COG1570	exodeoxyribonuclease VII activity
THEXY_RS06115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THEXY_RS06120	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
THEXY_RS06125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THEXY_RS06130	COG1438	arginine binding
THEXY_RS06135	COG0497	DNA recombination
THEXY_RS06140	COG0750	zinc metalloprotease
THEXY_RS06175	COG0494	nUDIX hydrolase
THEXY_RS06180	COG1379	DNA repair
THEXY_RS06185	COG1300	Membrane
THEXY_RS06190	COG4974	Belongs to the 'phage' integrase family
THEXY_RS06195	COG1686	Belongs to the peptidase S11 family
THEXY_RS06215	COG3360	Dodecin
THEXY_RS06235	COG3620	sequence-specific DNA binding
THEXY_RS06235	COG0617	tRNA 3'-terminal CCA addition
THEXY_RS06235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEXY_RS06240	COG1994	Peptidase M50
THEXY_RS06250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THEXY_RS06260	COG3874	Sporulation protein YtfJ
THEXY_RS06265	COG1686	Belongs to the peptidase S11 family
THEXY_RS06275	COG0445	tRNA wobble uridine modification
THEXY_RS06280	COG1187	pseudouridine synthase activity
THEXY_RS06295	COG0010	Belongs to the arginase family
THEXY_RS06305	COG1388	LysM domain
THEXY_RS06315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THEXY_RS06330	COG2081	HI0933 family
THEXY_RS06340	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THEXY_RS06350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THEXY_RS06355	COG0539	negative regulation of cytoplasmic translation
THEXY_RS06365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THEXY_RS06370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEXY_RS06380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THEXY_RS06385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THEXY_RS06390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THEXY_RS06400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THEXY_RS06405	COG0328	RNA-DNA hybrid ribonuclease activity
THEXY_RS06410	COG4974	Belongs to the 'phage' integrase family
THEXY_RS06415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THEXY_RS06420	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
THEXY_RS06425	COG0464	growth
THEXY_RS06430	COG0017	Asparaginyl-tRNA synthetase
THEXY_RS06445	COG0613	PHP domain protein
THEXY_RS06450	COG2359	stage V sporulation protein S
THEXY_RS06455	COG1692	metallophosphoesterase
THEXY_RS06460	COG1418	mRNA catabolic process
THEXY_RS06465	COG0419	ATPase involved in DNA repair
THEXY_RS06490	COG2137	regulation of response to DNA damage stimulus
THEXY_RS06495	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THEXY_RS06505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THEXY_RS06510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEXY_RS06515	COG1674	ftsk spoiiie
THEXY_RS06525	COG0740	serine-type endopeptidase activity
THEXY_RS06530	COG0527	aspartate kinase activity
THEXY_RS06545	COG0756	dUTP diphosphatase activity
THEXY_RS06550	COG0612	Peptidase, M16
THEXY_RS06555	COG0726	polysaccharide deacetylase
THEXY_RS06560	COG1185	polyribonucleotide nucleotidyltransferase activity
THEXY_RS06565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THEXY_RS06570	COG0196	riboflavin kinase activity
THEXY_RS06575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THEXY_RS06580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEXY_RS06585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THEXY_RS06600	COG2740	Nucleic-acid-binding protein implicated in transcription termination
THEXY_RS06605	COG0195	Participates in both transcription termination and antitermination
THEXY_RS06610	COG0779	Required for maturation of 30S ribosomal subunits
THEXY_RS06615	COG2176	DNA-directed DNA polymerase activity
THEXY_RS06625	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THEXY_RS06630	COG0750	zinc metalloprotease
THEXY_RS06635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THEXY_RS06640	COG4589	Belongs to the CDS family
THEXY_RS06645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THEXY_RS06650	COG0233	cytoplasmic translational termination
THEXY_RS06655	COG0528	UMP kinase activity
THEXY_RS06680	COG1191	sigma factor activity
THEXY_RS06685	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THEXY_RS06690	COG1776	CheC inhibitor of MCP methylation
THEXY_RS06700	COG2198	Histidine kinase
THEXY_RS06700	COG0643	Histidine kinase
THEXY_RS06710	COG0455	bacterial-type flagellum organization
THEXY_RS06720	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THEXY_RS06725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THEXY_RS06730	COG1684	flagellar biosynthetic protein fliR
THEXY_RS06735	COG1987	bacterial-type flagellum assembly
THEXY_RS06740	COG1338	Plays a role in the flagellum-specific transport system
THEXY_RS06750	COG2201	protein-glutamate methylesterase activity
THEXY_RS06755	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THEXY_RS06755	COG1776	CheC inhibitor of MCP methylation
THEXY_RS06760	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THEXY_RS06765	COG1580	Controls the rotational direction of flagella during chemotaxis
THEXY_RS06780	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THEXY_RS06800	COG1157	protein secretion by the type III secretion system
THEXY_RS06810	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THEXY_RS06815	COG1766	The M ring may be actively involved in energy transduction
THEXY_RS06820	COG1677	Flagellar hook-basal body complex protein FliE
THEXY_RS06825	COG1558	bacterial-type flagellum-dependent cell motility
THEXY_RS06830	COG1815	bacterial-type flagellum-dependent cell motility
THEXY_RS06840	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THEXY_RS06845	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THEXY_RS06850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THEXY_RS06855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THEXY_RS06855	COG0758	DNA mediated transformation
THEXY_RS06860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THEXY_RS06865	COG0792	nuclease activity
THEXY_RS06870	COG0180	Tryptophanyl-tRNA synthetase
THEXY_RS06875	COG0606	chelatase, subunit chli
THEXY_RS06890	COG0336	Belongs to the RNA methyltransferase TrmD family
THEXY_RS06900	COG1837	Belongs to the UPF0109 family
THEXY_RS06910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THEXY_RS06915	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
THEXY_RS06920	COG0552	protein localization to endoplasmic reticulum
THEXY_RS06930	COG2359	stage V sporulation protein S
THEXY_RS06940	COG0571	ribonuclease III activity
THEXY_RS06945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THEXY_RS06955	COG1028	Short-chain dehydrogenase reductase Sdr
THEXY_RS06960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THEXY_RS06965	COG2070	2-Nitropropane dioxygenase
THEXY_RS06970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THEXY_RS06975	COG0416	fatty acid biosynthetic process
THEXY_RS06980	COG2030	dehydratase
THEXY_RS06985	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THEXY_RS06990	COG1399	metal-binding, possibly nucleic acid-binding protein
THEXY_RS06995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THEXY_RS07000	COG0280	phosphate acetyltransferase
THEXY_RS07010	COG3314	Sporulation integral membrane protein YlbJ
THEXY_RS07020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THEXY_RS07025	COG0742	ribosomal rna small subunit methyltransferase
THEXY_RS07035	COG1307	EDD domain protein, DegV family
THEXY_RS07040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THEXY_RS07045	COG1461	Dihydroxyacetone kinase
THEXY_RS07050	COG1302	Protein conserved in bacteria
THEXY_RS07070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THEXY_RS07075	COG1162	GTPase activity
THEXY_RS07080	COG0515	serine threonine protein kinase
THEXY_RS07080	COG2815	serine threonine protein kinase
THEXY_RS07085	COG0631	protein serine/threonine phosphatase activity
THEXY_RS07095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THEXY_RS07095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THEXY_RS07100	COG2738	Putative neutral zinc metallopeptidase
THEXY_RS07110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THEXY_RS07115	COG0242	peptide deformylase activity
THEXY_RS07120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THEXY_RS07125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THEXY_RS07135	COG0194	GDP metabolic process
THEXY_RS07145	COG1561	YicC-like family, N-terminal region
THEXY_RS07150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THEXY_RS07160	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
THEXY_RS07200	COG0167	dihydroorotate dehydrogenase activity
THEXY_RS07205	COG0543	2 iron, 2 sulfur cluster binding
THEXY_RS07220	COG0540	Belongs to the ATCase OTCase family
THEXY_RS07230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THEXY_RS07235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEXY_RS07245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THEXY_RS07250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THEXY_RS07255	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THEXY_RS07255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THEXY_RS07270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THEXY_RS07275	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THEXY_RS07300	COG3547	Transposase (IS116 IS110 IS902 family)
THEXY_RS07305	COG0343	queuine tRNA-ribosyltransferase activity
THEXY_RS07310	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THEXY_RS07315	COG2247	cell wall binding repeat
THEXY_RS07315	COG2385	sporulation resulting in formation of a cellular spore
THEXY_RS07335	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THEXY_RS07350	COG0217	transcriptional regulatory protein
THEXY_RS07355	COG0730	response to heat
THEXY_RS07380	COG1739	Uncharacterized protein family UPF0029
THEXY_RS07385	COG0494	nUDIX hydrolase
THEXY_RS07395	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THEXY_RS07415	COG1959	2 iron, 2 sulfur cluster binding
THEXY_RS07420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THEXY_RS07430	COG3118	belongs to the thioredoxin family
THEXY_RS07435	COG1937	Protein conserved in bacteria
THEXY_RS07440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THEXY_RS07450	COG0124	histidyl-tRNA synthetase
THEXY_RS07455	COG0564	pseudouridine synthase activity
THEXY_RS07460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THEXY_RS07470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THEXY_RS07490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THEXY_RS07510	COG0134	indole-3-glycerol-phosphate synthase activity
THEXY_RS07520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THEXY_RS07520	COG0512	Glutamine amidotransferase of anthranilate synthase
THEXY_RS07530	COG3464	Transposase
THEXY_RS07540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THEXY_RS07555	COG3599	regulation of cell shape
THEXY_RS07560	COG2302	S4 RNA-binding domain
THEXY_RS07575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THEXY_RS07605	COG0557	exoribonuclease II activity
THEXY_RS07625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEXY_RS07625	COG0574	Belongs to the PEP-utilizing enzyme family
THEXY_RS07635	COG0423	glycine-tRNA ligase activity
THEXY_RS07660	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THEXY_RS07670	COG1480	7TM receptor with intracellular HD hydrolase
THEXY_RS07675	COG1702	phosphate starvation-inducible protein PhoH
THEXY_RS07690	COG1610	YqeY-like protein
THEXY_RS07700	COG0537	adenosine 5'-monophosphoramidase activity
THEXY_RS07705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEXY_RS07710	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THEXY_RS07715	COG2264	protein methyltransferase activity
THEXY_RS07720	COG0484	heat shock protein binding
THEXY_RS07725	COG0443	Heat shock 70 kDa protein
THEXY_RS07730	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THEXY_RS07740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THEXY_RS07745	COG0481	GTPase activity
THEXY_RS07755	COG0438	transferase activity, transferring glycosyl groups
THEXY_RS07765	COG0860	N-Acetylmuramoyl-L-alanine amidase
THEXY_RS07775	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THEXY_RS07785	COG0268	Binds directly to 16S ribosomal RNA
THEXY_RS07795	COG0658	competence protein
THEXY_RS07795	COG2333	competence protein COMEC
THEXY_RS07805	COG0546	phosphoglycolate phosphatase activity
THEXY_RS07820	COG1131	(ABC) transporter
THEXY_RS07845	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THEXY_RS07850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THEXY_RS07860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THEXY_RS07870	COG0438	transferase activity, transferring glycosyl groups
THEXY_RS07875	COG0438	transferase activity, transferring glycosyl groups
THEXY_RS07890	COG0493	'glutamate synthase
THEXY_RS07910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THEXY_RS07915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THEXY_RS07920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THEXY_RS07930	COG1555	photosystem II stabilization
THEXY_RS07930	COG1596	polysaccharide export
THEXY_RS07935	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
THEXY_RS07940	COG2964	Protein conserved in bacteria
THEXY_RS07945	COG0799	negative regulation of ribosome biogenesis
THEXY_RS07950	COG1713	HD superfamily hydrolase involved in NAD metabolism
THEXY_RS07985	COG1530	ribonuclease E activity
THEXY_RS08000	COG0517	IMP dehydrogenase activity
THEXY_RS08000	COG1994	Peptidase M50
THEXY_RS08005	COG0739	heme binding
THEXY_RS08005	COG1388	LysM domain
THEXY_RS08015	COG0772	Belongs to the SEDS family
THEXY_RS08025	COG2894	cell division
THEXY_RS08050	COG1077	Cell shape determining protein MreB Mrl
THEXY_RS08055	COG2003	Belongs to the UPF0758 family
THEXY_RS08105	COG2878	Part of a membrane complex involved in electron transport
THEXY_RS08110	COG2172	sigma factor antagonist activity
THEXY_RS08125	COG0741	lytic transglycosylase activity
THEXY_RS08130	COG1217	gtp-binding protein TYPA
THEXY_RS08135	COG0791	NLP P60 protein
THEXY_RS08155	COG2707	UPF0756 membrane protein
THEXY_RS08160	COG0741	lytic transglycosylase activity
THEXY_RS08165	COG0237	dephospho-CoA kinase activity
THEXY_RS08180	COG1595	DNA-templated transcription, initiation
THEXY_RS08185	COG1376	ErfK ybiS ycfS ynhG family protein
THEXY_RS08195	COG1113	amino acid transport
THEXY_RS08200	COG1983	PspC domain protein
THEXY_RS08205	COG1388	LysM domain
THEXY_RS08205	COG3858	chitin binding
THEXY_RS08215	COG4475	Protein of unknown function (DUF436)
THEXY_RS08220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THEXY_RS08240	COG0745	RESPONSE REGULATOR receiver
THEXY_RS08250	COG1013	pyruvate-flavodoxin oxidoreductase activity
THEXY_RS08255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THEXY_RS08255	COG0674	pyruvate-flavodoxin oxidoreductase activity
THEXY_RS08265	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
THEXY_RS08270	COG0346	lactoylglutathione lyase activity
THEXY_RS08280	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEXY_RS08280	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEXY_RS08285	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEXY_RS08285	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THEXY_RS08305	COG1297	OPT oligopeptide transporter protein
THEXY_RS08330	COG3426	butyrate kinase activity
THEXY_RS08340	COG0280	phosphate acetyltransferase
THEXY_RS08370	COG0739	heme binding
THEXY_RS08380	COG3858	chitin binding
THEXY_RS08395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THEXY_RS08400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
THEXY_RS08415	COG1252	NADH dehydrogenase
THEXY_RS08440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THEXY_RS08450	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THEXY_RS08455	COG2171	N-acyltransferase activity
THEXY_RS08475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THEXY_RS08495	COG2182	Extracellular solute-binding protein
THEXY_RS08505	COG0395	ABC-type sugar transport system, permease component
THEXY_RS08510	COG1175	transmembrane transport
THEXY_RS08535	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THEXY_RS08560	COG3464	Transposase
THEXY_RS08570	COG0285	dihydrofolate synthase activity
THEXY_RS08580	COG0525	valine-tRNA ligase activity
THEXY_RS08585	COG1268	BioY protein
THEXY_RS08590	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THEXY_RS08595	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THEXY_RS08600	COG1691	(AIR) carboxylase
THEXY_RS08605	COG1606	tRNA processing
THEXY_RS08610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THEXY_RS08620	COG0671	phosphoesterase, PA-phosphatase related
THEXY_RS08625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THEXY_RS08630	COG0426	domain, Protein
THEXY_RS08645	COG2814	Major facilitator Superfamily
THEXY_RS08660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THEXY_RS08670	COG3949	Membrane
THEXY_RS08675	COG1316	TRANSCRIPTIONal
THEXY_RS08695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THEXY_RS08700	COG4464	protein tyrosine phosphatase activity
THEXY_RS08705	COG0489	protein tyrosine kinase activity
THEXY_RS08710	COG3944	biosynthesis protein
THEXY_RS08750	COG1942	4-Oxalocrotonate Tautomerase
THEXY_RS08790	COG0395	ABC-type sugar transport system, permease component
THEXY_RS08795	COG1175	transmembrane transport
THEXY_RS08800	COG1653	transport
THEXY_RS08820	COG0395	ABC-type sugar transport system, permease component
THEXY_RS08825	COG4209	transmembrane transport
THEXY_RS08835	COG3275	phosphorelay sensor kinase activity
THEXY_RS08840	COG4753	response regulator
THEXY_RS08840	COG2207	Transcriptional regulator
THEXY_RS08840	COG4753	response regulator
THEXY_RS08840	COG2207	Transcriptional regulator
THEXY_RS08845	COG3458	cephalosporin-C deacetylase activity
THEXY_RS08850	COG3664	PFAM glycoside hydrolase family 39
THEXY_RS08865	COG0673	inositol 2-dehydrogenase activity
THEXY_RS08885	COG0395	ABC-type sugar transport system, permease component
THEXY_RS08890	COG4209	transmembrane transport
THEXY_RS08895	COG1312	Catalyzes the dehydration of D-mannonate
THEXY_RS08900	COG1802	Transcriptional regulator
THEXY_RS08915	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THEXY_RS08955	COG1401	restriction endodeoxyribonuclease activity
THEXY_RS08980	COG1201	RNA secondary structure unwinding
THEXY_RS09000	COG3464	Transposase
THEXY_RS09015	COG3465	dGTPase activity
THEXY_RS09020	COG1078	dGTPase activity
THEXY_RS09035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THEXY_RS09070	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
THEXY_RS09070	COG0662	Cupin 2, conserved barrel domain protein
THEXY_RS09125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
THEXY_RS09150	COG1216	Glycosyl transferase, family 2
THEXY_RS09150	COG0463	Glycosyl transferase, family 2
THEXY_RS09215	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
THEXY_RS09225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THEXY_RS09230	COG1116	anion transmembrane transporter activity
THEXY_RS09235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THEXY_RS09240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THEXY_RS09240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THEXY_RS09255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THEXY_RS09260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THEXY_RS09265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THEXY_RS09270	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THEXY_RS09275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THEXY_RS09280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THEXY_RS09285	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THEXY_RS09290	COG0356	it plays a direct role in the translocation of protons across the membrane
THEXY_RS09300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THEXY_RS09310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THEXY_RS09325	COG1234	tRNA 3'-trailer cleavage
THEXY_RS09330	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THEXY_RS09340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THEXY_RS09355	COG3546	catalase activity
THEXY_RS09360	COG0646	methionine synthase
THEXY_RS09360	COG1410	methionine synthase
THEXY_RS09365	COG0646	methionine synthase
THEXY_RS09365	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THEXY_RS09390	COG0778	Nitroreductase
THEXY_RS09395	COG2195	Cleaves the N-terminal amino acid of tripeptides
THEXY_RS09415	COG1199	ATP-dependent helicase activity
THEXY_RS09480	COG1516	flagellar protein fliS
THEXY_RS09485	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THEXY_RS09520	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THEXY_RS09525	COG0110	maltose O-acetyltransferase activity
THEXY_RS09530	COG2089	acid synthase
THEXY_RS09535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THEXY_RS09540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THEXY_RS09540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THEXY_RS09545	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THEXY_RS09550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THEXY_RS09555	COG1086	Polysaccharide biosynthesis protein
THEXY_RS09560	COG2604	Protein of unknown function DUF115
THEXY_RS09585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THEXY_RS09590	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THEXY_RS09595	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
THEXY_RS09605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THEXY_RS09610	COG4786	Flagellar basal body rod
THEXY_RS09610	COG1256	bacterial-type flagellum assembly
THEXY_RS09630	COG1040	competence protein
THEXY_RS09635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THEXY_RS09645	COG2199	diguanylate cyclase activity
THEXY_RS09645	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEXY_RS09650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THEXY_RS09655	COG1592	Rubrerythrin
THEXY_RS09660	COG0450	alkyl hydroperoxide reductase
THEXY_RS09700	COG5002	protein histidine kinase activity
THEXY_RS09705	COG0745	RESPONSE REGULATOR receiver
THEXY_RS09710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
THEXY_RS09715	COG1609	Transcriptional regulator
THEXY_RS09720	COG0561	phosphatase activity
THEXY_RS09725	COG2323	membrane
THEXY_RS09775	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THEXY_RS09785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THEXY_RS09790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEXY_RS09795	COG3711	transcriptional antiterminator
THEXY_RS09800	COG2190	(PTS) system
THEXY_RS09805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THEXY_RS09805	COG1263	PTS System
THEXY_RS09815	COG0840	transmembrane signaling receptor activity
THEXY_RS09835	COG2188	Transcriptional regulator
THEXY_RS09840	COG1079	Belongs to the binding-protein-dependent transport system permease family
THEXY_RS09845	COG4603	Belongs to the binding-protein-dependent transport system permease family
THEXY_RS09850	COG3845	ABC transporter
THEXY_RS09855	COG1744	ABC transporter substrate-binding protein PnrA-like
THEXY_RS09910	COG0484	heat shock protein binding
THEXY_RS09935	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
THEXY_RS09940	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
THEXY_RS09945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THEXY_RS09970	COG1797	cobyrinic acid a,c-diamide synthase activity
THEXY_RS09975	COG1120	ATPase activity
THEXY_RS09980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THEXY_RS09985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THEXY_RS10020	COG0531	amino acid
THEXY_RS10025	COG0116	Belongs to the methyltransferase superfamily
THEXY_RS10030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THEXY_RS10040	COG1522	sequence-specific DNA binding
THEXY_RS10045	COG0436	Aminotransferase
THEXY_RS10060	COG0671	phosphoesterase, PA-phosphatase related
THEXY_RS10065	COG0735	belongs to the Fur family
THEXY_RS10070	COG0803	Belongs to the bacterial solute-binding protein 9 family
THEXY_RS10075	COG1121	(ABC) transporter
THEXY_RS10080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THEXY_RS10100	COG0730	response to heat
THEXY_RS10105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THEXY_RS10110	COG0737	Belongs to the 5'-nucleotidase family
THEXY_RS10120	COG1447	Phosphotransferase system cellobiose-specific component IIA
THEXY_RS10130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
THEXY_RS10140	COG3933	PFAM sigma-54 factor interaction domain-containing protein
THEXY_RS10140	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
THEXY_RS10145	COG0531	amino acid
THEXY_RS10150	COG1392	Phosphate transport regulator
THEXY_RS10155	COG0306	phosphate transporter
THEXY_RS10170	COG0495	leucyl-tRNA aminoacylation
THEXY_RS10195	COG2201	protein-glutamate methylesterase activity
THEXY_RS10200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THEXY_RS10210	COG0643	Histidine kinase
THEXY_RS10210	COG2198	Histidine kinase
THEXY_RS10215	COG0835	chemotaxis
THEXY_RS10230	COG0582	viral genome integration into host DNA
THEXY_RS10235	COG0436	Aminotransferase
THEXY_RS10240	COG4214	carbohydrate transport
THEXY_RS10255	COG4213	ABC transporter substrate-binding protein
THEXY_RS10260	COG4753	response regulator
THEXY_RS10260	COG2207	Transcriptional regulator
THEXY_RS10265	COG3275	phosphorelay sensor kinase activity
THEXY_RS10310	COG1028	Short-chain dehydrogenase reductase Sdr
THEXY_RS10315	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
THEXY_RS10320	COG1609	Transcriptional regulator
THEXY_RS10330	COG0246	Mannitol dehydrogenase
THEXY_RS10335	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THEXY_RS10340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
THEXY_RS10345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THEXY_RS10355	COG1349	DNA-binding transcription factor activity
THEXY_RS10365	COG0534	Mate efflux family protein
THEXY_RS10375	COG2721	sulfolactate sulfo-lyase activity
THEXY_RS10380	COG0246	Mannitol dehydrogenase
THEXY_RS10390	COG0395	ABC-type sugar transport system, permease component
THEXY_RS10395	COG1175	transmembrane transport
THEXY_RS10405	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
THEXY_RS10410	COG1609	Transcriptional regulator
THEXY_RS10415	COG1904	glucuronate isomerase
THEXY_RS10420	COG1388	LysM domain
THEXY_RS10420	COG3858	chitin binding
THEXY_RS10430	COG0493	'glutamate synthase
THEXY_RS10445	COG0039	L-malate dehydrogenase activity
THEXY_RS10465	COG0586	Pfam SNARE associated Golgi protein
THEXY_RS10470	COG0297	glycogen (starch) synthase activity
THEXY_RS10520	COG3507	Belongs to the glycosyl hydrolase 43 family
THEXY_RS10530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THEXY_RS10535	COG0395	ABC-type sugar transport system, permease component
THEXY_RS10540	COG1175	transmembrane transport
THEXY_RS10555	COG1070	Carbohydrate kinase
THEXY_RS10560	COG4806	L-rhamnose isomerase
THEXY_RS10575	COG4656	Part of a membrane complex involved in electron transport
THEXY_RS10580	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
THEXY_RS10585	COG4869	propanediol catabolic process
THEXY_RS10610	COG1063	alcohol dehydrogenase
THEXY_RS10655	COG1349	DNA-binding transcription factor activity
THEXY_RS10670	COG3875	lactate racemase activity
THEXY_RS10675	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THEXY_RS10685	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THEXY_RS10705	COG0534	Mate efflux family protein
THEXY_RS10710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THEXY_RS10735	COG1131	(ABC) transporter
THEXY_RS10745	COG0864	Transcriptional regulator
THEXY_RS10750	COG0310	cobalt ion transport
THEXY_RS10755	COG0310	cobalt ion transport
THEXY_RS10765	COG1122	ATPase activity
THEXY_RS10770	COG3344	reverse transcriptase
THEXY_RS10775	COG2814	Major facilitator Superfamily
THEXY_RS10820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEXY_RS10835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THEXY_RS10840	COG0800	Aldolase
THEXY_RS10845	COG1609	Transcriptional regulator
THEXY_RS10855	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THEXY_RS10865	COG1070	Carbohydrate kinase
THEXY_RS10875	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEXY_RS10875	COG1902	pentaerythritol trinitrate reductase activity
THEXY_RS10880	COG0583	DNA-binding transcription factor activity
THEXY_RS10895	COG4632	Exopolysaccharide biosynthesis protein
THEXY_RS10895	COG5434	Belongs to the glycosyl hydrolase 28 family
THEXY_RS10910	COG1979	alcohol dehydrogenase
THEXY_RS10920	COG0463	Glycosyl transferase, family 2
THEXY_RS10920	COG0457	Tetratricopeptide repeat
THEXY_RS10925	COG0840	transmembrane signaling receptor activity
THEXY_RS10930	COG1496	oxidoreductase activity
THEXY_RS10945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THEXY_RS10965	COG1132	(ABC) transporter
THEXY_RS10980	COG4786	Flagellar basal body rod
THEXY_RS10990	COG1609	Transcriptional regulator
THEXY_RS11000	COG2385	sporulation resulting in formation of a cellular spore
THEXY_RS11035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THEXY_RS11040	COG0531	amino acid
THEXY_RS11050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THEXY_RS11060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THEXY_RS11065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THEXY_RS11080	COG0698	ribose 5-phosphate isomerase
THEXY_RS11085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THEXY_RS11090	COG0009	L-threonylcarbamoyladenylate synthase
THEXY_RS11105	COG2890	protein-(glutamine-N5) methyltransferase activity
THEXY_RS11110	COG3872	metal-dependent enzyme
THEXY_RS11120	COG0254	rRNA binding
THEXY_RS11125	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THEXY_RS11140	COG0745	RESPONSE REGULATOR receiver
THEXY_RS11145	COG2247	cell wall binding repeat
THEXY_RS11145	COG0860	N-Acetylmuramoyl-L-alanine amidase
THEXY_RS11155	COG1132	(ABC) transporter
THEXY_RS11160	COG1132	(ABC) transporter
THEXY_RS11180	COG2723	6-phospho-beta-galactosidase activity
THEXY_RS11190	COG1175	transmembrane transport
THEXY_RS11200	COG1609	Transcriptional regulator
THEXY_RS11230	COG0840	transmembrane signaling receptor activity
THEXY_RS11245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEXY_RS11245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THEXY_RS11245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEXY_RS11250	COG1105	Belongs to the carbohydrate kinase PfkB family
THEXY_RS11255	COG1349	DNA-binding transcription factor activity
THEXY_RS11290	COG0463	Glycosyl transferase, family 2
THEXY_RS11295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THEXY_RS11310	COG2770	Histidine kinase
THEXY_RS11310	COG2205	protein histidine kinase activity
THEXY_RS11315	COG0745	RESPONSE REGULATOR receiver
THEXY_RS11320	COG2373	Large extracellular alpha-helical protein
THEXY_RS11350	COG0504	CTP synthase activity
THEXY_RS11355	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THEXY_RS11380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THEXY_RS11385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THEXY_RS11390	COG1929	Belongs to the glycerate kinase type-1 family
THEXY_RS11395	COG3409	Peptidoglycan-binding domain 1 protein
THEXY_RS11395	COG0793	Belongs to the peptidase S41A family
THEXY_RS11400	COG3547	Transposase (IS116 IS110 IS902 family)
THEXY_RS11405	COG0083	homoserine kinase activity
THEXY_RS11410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THEXY_RS11415	COG0460	homoserine dehydrogenase
THEXY_RS11430	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
THEXY_RS11435	COG0674	pyruvate-flavodoxin oxidoreductase activity
THEXY_RS11435	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THEXY_RS11440	COG1013	pyruvate-flavodoxin oxidoreductase activity
THEXY_RS11445	COG1132	(ABC) transporter
THEXY_RS11455	COG1846	Transcriptional regulator
THEXY_RS11465	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THEXY_RS11470	COG1518	maintenance of DNA repeat elements
THEXY_RS11525	COG1337	RAMP superfamily
THEXY_RS11560	COG0822	iron-sulfur transferase activity
THEXY_RS11565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THEXY_RS11570	COG0719	Fe-S assembly protein
THEXY_RS11575	COG0719	Fe-S assembly protein
THEXY_RS11635	COG1714	RDD family
THEXY_RS11680	COG1012	belongs to the aldehyde dehydrogenase family
THEXY_RS11680	COG1454	alcohol dehydrogenase
THEXY_RS11690	COG0667	Aldo Keto reductase
THEXY_RS11710	COG1924	4 iron, 4 sulfur cluster binding
THEXY_RS11730	COG2203	Gaf domain
THEXY_RS11730	COG2199	diguanylate cyclase activity
THEXY_RS11735	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THEXY_RS11740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEXY_RS11745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THEXY_RS11765	COG5002	protein histidine kinase activity
THEXY_RS11770	COG0745	RESPONSE REGULATOR receiver
THEXY_RS11835	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THEXY_RS11840	COG1518	maintenance of DNA repeat elements
THEXY_RS11920	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
THEXY_RS11965	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
THEXY_RS11990	COG5002	protein histidine kinase activity
THEXY_RS11990	COG3850	Histidine kinase
THEXY_RS12005	COG2239	Acts as a magnesium transporter
THEXY_RS12015	COG0305	Participates in initiation and elongation during chromosome replication
THEXY_RS12025	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
THEXY_RS12045	COG0629	single-stranded DNA binding
THEXY_RS12050	COG0360	Binds together with S18 to 16S ribosomal RNA
THEXY_RS12055	COG4481	Protein conserved in bacteria
THEXY_RS12060	COG0668	transmembrane transport
THEXY_RS12085	COG1597	lipid kinase activity
THEXY_RS12095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THEXY_RS12100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THEXY_RS12105	COG1475	DNA binding
THEXY_RS12110	COG1192	Involved in chromosome partitioning
THEXY_RS12115	COG1475	DNA binding
THEXY_RS12125	COG0357	Ribosomal RNA small subunit methyltransferase G
THEXY_RS12135	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THEXY_RS12140	COG1847	R3H domain protein
THEXY_RS12145	COG0706	membrane insertase activity
THEXY_RS12180	COG2204	response regulator
THEXY_RS12185	COG3829	transcription factor binding
THEXY_RS12210	COG0745	RESPONSE REGULATOR receiver