locus-tag	class	description
BR63_RS00030	COG0739	heme binding
BR63_RS00030	COG0741	lytic transglycosylase activity
BR63_RS00030	COG1196	nuclear chromosome segregation
BR63_RS00085	COG1595	DNA-templated transcription, initiation
BR63_RS00095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BR63_RS00095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BR63_RS00100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BR63_RS00105	COG0237	dephospho-CoA kinase activity
BR63_RS00130	COG2135	peptidase activity
BR63_RS00150	COG0247	lactate metabolic process
BR63_RS00150	COG2181	nitrate reductase activity
BR63_RS00160	COG2508	Transcriptional regulator
BR63_RS00160	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BR63_RS00175	COG1473	amidohydrolase
BR63_RS00225	COG3290	protein histidine kinase activity
BR63_RS00260	COG3290	protein histidine kinase activity
BR63_RS00270	COG3279	Response regulator of the LytR AlgR family
BR63_RS00350	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BR63_RS00355	COG3290	protein histidine kinase activity
BR63_RS00355	COG3290	protein histidine kinase activity
BR63_RS00355	COG3829	transcription factor binding
BR63_RS00355	COG3829	transcription factor binding
BR63_RS00390	COG0745	RESPONSE REGULATOR receiver
BR63_RS00395	COG5002	protein histidine kinase activity
BR63_RS00400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BR63_RS00405	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BR63_RS00425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BR63_RS00430	COG0569	domain protein
BR63_RS00455	COG1333	cytochrome c biogenesis protein
BR63_RS00460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BR63_RS00470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BR63_RS00490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BR63_RS00500	COG0719	Fe-S assembly protein
BR63_RS00505	COG0697	spore germination
BR63_RS00520	COG3875	lactate racemase activity
BR63_RS00530	COG2721	sulfolactate sulfo-lyase activity
BR63_RS00535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BR63_RS00540	COG0129	dihydroxy-acid dehydratase activity
BR63_RS00550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BR63_RS00550	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_RS00555	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_RS00570	COG0183	Belongs to the thiolase family
BR63_RS00575	COG1250	3-hydroxyacyl-CoA dehydrogenase
BR63_RS00580	COG1024	Enoyl-CoA hydratase
BR63_RS00585	COG2186	Transcriptional regulator
BR63_RS00600	COG0456	acetyltransferase
BR63_RS00600	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BR63_RS00625	COG0730	response to heat
BR63_RS00640	COG0367	asparagine synthase
BR63_RS00645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BR63_RS00660	COG2223	nitrite transmembrane transporter activity
BR63_RS00665	COG1993	acr, cog1993
BR63_RS00670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BR63_RS00680	COG0348	domain, Protein
BR63_RS00725	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BR63_RS00730	COG3639	organic phosphonate transmembrane transporter activity
BR63_RS00760	COG3627	carbon phosphorus lyase activity
BR63_RS00765	COG4107	phosphonate C-P lyase system protein PhnK
BR63_RS00770	COG3454	Phosphonate metabolism
BR63_RS00780	COG4778	phosphonate C-P lyase system protein PhnL
BR63_RS00785	COG0613	PHP domain protein
BR63_RS00805	COG1940	carbohydrate kinase activity
BR63_RS00820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BR63_RS00825	COG3103	Sh3 type 3 domain protein
BR63_RS00825	COG0366	Alpha amylase catalytic
BR63_RS00860	COG0658	competence protein
BR63_RS00860	COG2333	competence protein COMEC
BR63_RS00915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BR63_RS00925	COG1543	Belongs to the glycosyl hydrolase 57 family
BR63_RS00955	COG1301	dicarboxylic acid transport
BR63_RS00960	COG1024	Enoyl-CoA hydratase
BR63_RS00965	COG0427	acetyl-CoA hydrolase
BR63_RS00970	COG1024	Enoyl-CoA hydratase
BR63_RS00970	COG1250	3-hydroxyacyl-CoA dehydrogenase
BR63_RS00975	COG0183	Belongs to the thiolase family
BR63_RS00980	COG3852	Histidine kinase
BR63_RS01005	COG3852	Histidine kinase
BR63_RS01015	COG0730	response to heat
BR63_RS01020	COG1238	metal cluster binding
BR63_RS01035	COG1595	DNA-templated transcription, initiation
BR63_RS01045	COG2204	response regulator
BR63_RS01055	COG0006	proline dipeptidase activity
BR63_RS01065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BR63_RS01090	COG2309	aminopeptidase activity
BR63_RS01100	COG3835	regulator
BR63_RS01105	COG0446	pyridine nucleotide-disulphide oxidoreductase
BR63_RS01105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BR63_RS01135	COG2414	aldehyde ferredoxin oxidoreductase
BR63_RS01145	COG0067	glutamate synthase
BR63_RS01150	COG0069	glutamate synthase activity
BR63_RS01155	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BR63_RS01170	COG0174	glutamine synthetase
BR63_RS01175	COG0347	Belongs to the P(II) protein family
BR63_RS01180	COG0004	ammonium transporteR
BR63_RS01200	COG1410	methionine synthase
BR63_RS01200	COG0646	methionine synthase
BR63_RS01205	COG4942	peptidase
BR63_RS01225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BR63_RS01235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BR63_RS01245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BR63_RS01255	COG1988	membrane-bound metal-dependent
BR63_RS01280	COG1988	membrane-bound metal-dependent
BR63_RS01305	COG2707	UPF0756 membrane protein
BR63_RS01310	COG2814	Major facilitator Superfamily
BR63_RS01325	COG0546	phosphoglycolate phosphatase activity
BR63_RS01335	COG0494	nUDIX hydrolase
BR63_RS01340	COG5002	protein histidine kinase activity
BR63_RS01345	COG0745	RESPONSE REGULATOR receiver
BR63_RS01355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BR63_RS01365	COG0835	chemotaxis
BR63_RS01385	COG1533	DNA photolyase activity
BR63_RS01390	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BR63_RS01395	COG0860	N-Acetylmuramoyl-L-alanine amidase
BR63_RS01445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BR63_RS01475	COG1191	sigma factor activity
BR63_RS01480	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BR63_RS01480	COG0165	Argininosuccinate lyase
BR63_RS01485	COG1191	sigma factor activity
BR63_RS01495	COG1873	PFAM PRC-barrel domain
BR63_RS01555	COG1024	Enoyl-CoA hydratase
BR63_RS01560	COG0436	Aminotransferase
BR63_RS01580	COG1271	oxidase subunit
BR63_RS01585	COG1294	oxidase, subunit
BR63_RS01590	COG4988	ABC transporter
BR63_RS01595	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BR63_RS01610	COG2340	Cysteine-rich secretory protein family
BR63_RS01640	COG0463	Glycosyl transferase, family 2
BR63_RS01640	COG0457	Tetratricopeptide repeat
BR63_RS01645	COG0457	Tetratricopeptide repeat
BR63_RS01645	COG0463	Glycosyl transferase, family 2
BR63_RS01685	COG2340	Cysteine-rich secretory protein family
BR63_RS01720	COG1496	oxidoreductase activity
BR63_RS01725	COG0745	RESPONSE REGULATOR receiver
BR63_RS01730	COG5002	protein histidine kinase activity
BR63_RS01735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BR63_RS01750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BR63_RS01755	COG1799	cell septum assembly
BR63_RS01760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BR63_RS01765	COG0762	integral membrane protein
BR63_RS01775	COG3599	regulation of cell shape
BR63_RS01780	COG1872	DUF167
BR63_RS01785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BR63_RS01790	COG3275	phosphorelay sensor kinase activity
BR63_RS01795	COG3279	Response regulator of the LytR AlgR family
BR63_RS01815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BR63_RS01820	COG4770	biotin carboxylase activity
BR63_RS01825	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BR63_RS01835	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_RS01840	COG1063	alcohol dehydrogenase
BR63_RS01850	COG1414	Transcriptional regulator
BR63_RS01855	COG2081	HI0933 family
BR63_RS01865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BR63_RS01870	COG0509	glycine decarboxylation via glycine cleavage system
BR63_RS01875	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BR63_RS01880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BR63_RS01895	COG3344	reverse transcriptase
BR63_RS01900	COG1802	Transcriptional regulator
BR63_RS01905	COG4948	Mandelate Racemase Muconate Lactonizing
BR63_RS01935	COG2414	aldehyde ferredoxin oxidoreductase
BR63_RS01980	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BR63_RS01985	COG0347	Belongs to the P(II) protein family
BR63_RS01990	COG0347	Belongs to the P(II) protein family
BR63_RS02035	COG3842	ATPase activity
BR63_RS02045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BR63_RS02055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BR63_RS02065	COG0517	IMP dehydrogenase activity
BR63_RS02065	COG0516	GMP reductase activity
BR63_RS02075	COG0411	ABC transporter
BR63_RS02090	COG0683	leucine binding
BR63_RS02095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BR63_RS02100	COG1116	anion transmembrane transporter activity
BR63_RS02105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BR63_RS02115	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BR63_RS02180	COG5012	cobalamin binding
BR63_RS02195	COG3679	Belongs to the UPF0342 family
BR63_RS02225	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BR63_RS02235	COG1363	Peptidase, m42
BR63_RS02245	COG1489	DNA binding
BR63_RS02260	COG1484	DNA-dependent DNA replication
BR63_RS02265	COG1960	acyl-CoA dehydrogenase activity
BR63_RS02270	COG2086	electron transfer activity
BR63_RS02275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_RS02295	COG2001	Belongs to the MraZ family
BR63_RS02300	COG0275	rRNA processing
BR63_RS02305	COG3116	cell division
BR63_RS02310	COG0768	penicillin binding
BR63_RS02315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BR63_RS02320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BR63_RS02325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BR63_RS02330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BR63_RS02335	COG0772	Belongs to the SEDS family
BR63_RS02340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BR63_RS02345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BR63_RS02350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BR63_RS02355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BR63_RS02360	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BR63_RS02365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BR63_RS02370	COG4399	Belongs to the UPF0754 family
BR63_RS02375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BR63_RS02380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BR63_RS02390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BR63_RS02395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BR63_RS02400	COG0569	domain protein
BR63_RS02405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BR63_RS02410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BR63_RS02415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BR63_RS02415	COG0072	phenylalanine-tRNA ligase activity
BR63_RS02420	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BR63_RS02425	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BR63_RS02425	COG1796	DNA polymerase
BR63_RS02435	COG0826	peptidase U32
BR63_RS02440	COG1193	negative regulation of DNA recombination
BR63_RS02445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BR63_RS02480	COG4191	Histidine kinase
BR63_RS02490	COG5002	protein histidine kinase activity
BR63_RS02500	COG0393	Putative heavy-metal-binding
BR63_RS02505	COG3584	3D domain protein
BR63_RS02505	COG3583	domain protein
BR63_RS02510	COG0217	transcriptional regulatory protein
BR63_RS02520	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BR63_RS02525	COG0632	four-way junction helicase activity
BR63_RS02530	COG2255	four-way junction helicase activity
BR63_RS02535	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BR63_RS02545	COG1191	sigma factor activity
BR63_RS02550	COG2755	lipolytic protein G-D-S-L family
BR63_RS02555	COG2385	sporulation resulting in formation of a cellular spore
BR63_RS02560	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BR63_RS02565	COG0343	queuine tRNA-ribosyltransferase activity
BR63_RS02570	COG1862	Preprotein translocase
BR63_RS02580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BR63_RS02585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BR63_RS02590	COG5416	Lipopolysaccharide assembly protein A domain
BR63_RS02595	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BR63_RS02595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BR63_RS02600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BR63_RS02610	COG1490	D-aminoacyl-tRNA deacylase activity
BR63_RS02615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BR63_RS02620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BR63_RS02625	COG0124	histidyl-tRNA synthetase
BR63_RS02630	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BR63_RS02640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BR63_RS02645	COG1937	Protein conserved in bacteria
BR63_RS02650	COG3118	belongs to the thioredoxin family
BR63_RS02665	COG1959	2 iron, 2 sulfur cluster binding
BR63_RS02670	COG1104	cysteine desulfurase activity
BR63_RS02675	COG0822	iron-sulfur transferase activity
BR63_RS02680	COG0482	sulfurtransferase activity
BR63_RS02700	COG0628	permease
BR63_RS02705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BR63_RS02710	COG4472	Bacterial protein of unknown function (DUF965)
BR63_RS02715	COG0667	Aldo Keto reductase
BR63_RS02730	COG3906	Belongs to the UPF0473 family
BR63_RS02735	COG2720	vancomycin resistance protein
BR63_RS02740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BR63_RS02745	COG4122	O-methyltransferase activity
BR63_RS02750	COG0826	peptidase U32
BR63_RS02760	COG0768	penicillin binding
BR63_RS02765	COG0697	spore germination
BR63_RS02770	COG1283	sodium-dependent phosphate transmembrane transporter activity
BR63_RS02785	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BR63_RS02810	COG3275	phosphorelay sensor kinase activity
BR63_RS02815	COG3279	Response regulator of the LytR AlgR family
BR63_RS02820	COG2358	TRAP transporter, solute receptor (TAXI family
BR63_RS02840	COG2610	gluconate transmembrane transporter activity
BR63_RS02850	COG2030	dehydratase
BR63_RS02855	COG0183	Belongs to the thiolase family
BR63_RS02860	COG1024	Enoyl-CoA hydratase
BR63_RS02870	COG1414	Transcriptional regulator
BR63_RS02875	COG0129	dihydroxy-acid dehydratase activity
BR63_RS02880	COG0800	Aldolase
BR63_RS02920	COG3620	sequence-specific DNA binding
BR63_RS02925	COG3620	sequence-specific DNA binding
BR63_RS02940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BR63_RS02960	COG1988	membrane-bound metal-dependent
BR63_RS03005	COG0739	heme binding
BR63_RS03005	COG0741	lytic transglycosylase activity
BR63_RS03005	COG1196	nuclear chromosome segregation
BR63_RS03080	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BR63_RS03125	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BR63_RS03260	COG3481	metal-dependent phosphohydrolase, HD sub domain
BR63_RS03310	COG0629	single-stranded DNA binding
BR63_RS03315	COG0675	Transposase, IS605 OrfB family
BR63_RS03445	COG0714	Associated with various cellular activities
BR63_RS03505	COG4974	Belongs to the 'phage' integrase family
BR63_RS03530	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BR63_RS03565	COG1215	transferase activity, transferring glycosyl groups
BR63_RS03610	COG1201	RNA secondary structure unwinding
BR63_RS03620	COG4717	serine-type aminopeptidase activity
BR63_RS03640	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BR63_RS03655	COG3481	metal-dependent phosphohydrolase, HD sub domain
BR63_RS03710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BR63_RS03750	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BR63_RS03765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BR63_RS03770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BR63_RS03780	COG1459	type II secretion system
BR63_RS03790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BR63_RS03840	COG0312	modulator of DNA gyrase
BR63_RS03845	COG0312	modulator of DNA gyrase
BR63_RS03850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BR63_RS03855	COG0006	proline dipeptidase activity
BR63_RS03870	COG3854	ATPases associated with a variety of cellular activities
BR63_RS03910	COG1302	Protein conserved in bacteria
BR63_RS03925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BR63_RS03930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BR63_RS03935	COG0543	2 iron, 2 sulfur cluster binding
BR63_RS03945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BR63_RS03950	COG1570	exodeoxyribonuclease VII activity
BR63_RS03965	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BR63_RS03970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BR63_RS03975	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BR63_RS03990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BR63_RS03995	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BR63_RS04005	COG0497	DNA recombination
BR63_RS04010	COG0750	zinc metalloprotease
BR63_RS04015	COG0745	RESPONSE REGULATOR receiver
BR63_RS04050	COG1379	DNA repair
BR63_RS04060	COG1300	Membrane
BR63_RS04065	COG1115	amino acid carrier protein
BR63_RS04090	COG4974	Belongs to the 'phage' integrase family
BR63_RS04095	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BR63_RS04105	COG1686	Belongs to the peptidase S11 family
BR63_RS04115	COG2172	sigma factor antagonist activity
BR63_RS04130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BR63_RS04155	COG0617	tRNA 3'-terminal CCA addition
BR63_RS04160	COG1994	Peptidase M50
BR63_RS04165	COG0180	Tryptophanyl-tRNA synthetase
BR63_RS04170	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BR63_RS04175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BR63_RS04185	COG3874	Sporulation protein YtfJ
BR63_RS04190	COG2715	membrane protein required for spore maturation
BR63_RS04195	COG0700	Nucleoside recognition
BR63_RS04200	COG1187	pseudouridine synthase activity
BR63_RS04215	COG1620	l-lactate permease
BR63_RS04220	COG0277	FAD linked oxidase domain protein
BR63_RS04240	COG4401	Chorismate mutase type I
BR63_RS04250	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BR63_RS04255	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BR63_RS04260	COG0204	Acyl-transferase
BR63_RS04265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BR63_RS04265	COG0539	negative regulation of cytoplasmic translation
BR63_RS04270	COG1304	FMN binding
BR63_RS04280	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_RS04280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BR63_RS04285	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_RS04295	COG0156	8-amino-7-oxononanoate synthase activity
BR63_RS04300	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
BR63_RS04310	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BR63_RS04325	COG1414	Transcriptional regulator
BR63_RS04360	COG0071	Belongs to the small heat shock protein (HSP20) family
BR63_RS04370	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BR63_RS04375	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BR63_RS04400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BR63_RS04405	COG3875	lactate racemase activity
BR63_RS04445	COG1181	Belongs to the D-alanine--D-alanine ligase family
BR63_RS04455	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BR63_RS04460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BR63_RS04470	COG0464	growth
BR63_RS04495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BR63_RS04540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BR63_RS04605	COG1923	regulation of RNA biosynthetic process
BR63_RS04610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BR63_RS04615	COG2136	Putative SAM-dependent methyltransferase
BR63_RS04615	COG2521	methyltransferase
BR63_RS04620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BR63_RS04625	COG0123	including yeast histone deacetylase and acetoin utilization protein
BR63_RS04635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BR63_RS04640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BR63_RS04645	COG1752	Esterase of the alpha-beta hydrolase superfamily
BR63_RS04655	COG1982	Orn Lys Arg decarboxylase major
BR63_RS04660	COG1077	Cell shape determining protein MreB Mrl
BR63_RS04665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BR63_RS04675	COG0517	IMP dehydrogenase activity
BR63_RS04675	COG0516	GMP reductase activity
BR63_RS04690	COG0588	phosphoglycerate mutase activity
BR63_RS04705	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BR63_RS04710	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BR63_RS04715	COG1797	cobyrinic acid a,c-diamide synthase activity
BR63_RS04725	COG1492	cobalamin metabolic process
BR63_RS04775	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BR63_RS04790	COG0613	PHP domain protein
BR63_RS04800	COG2359	stage V sporulation protein S
BR63_RS04805	COG1692	metallophosphoesterase
BR63_RS04815	COG1418	mRNA catabolic process
BR63_RS04825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BR63_RS04835	COG0513	Belongs to the DEAD box helicase family
BR63_RS04845	COG1546	Belongs to the CinA family
BR63_RS04845	COG1058	Belongs to the CinA family
BR63_RS04850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BR63_RS04855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BR63_RS04860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BR63_RS04860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BR63_RS04860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BR63_RS04870	COG1105	Belongs to the carbohydrate kinase PfkB family
BR63_RS04875	COG1349	DNA-binding transcription factor activity
BR63_RS04880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BR63_RS04890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BR63_RS04895	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BR63_RS04900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BR63_RS04910	COG1426	Protein conserved in bacteria
BR63_RS04915	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BR63_RS04920	COG1674	ftsk spoiiie
BR63_RS04930	COG0740	serine-type endopeptidase activity
BR63_RS04935	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BR63_RS04940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BR63_RS04945	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BR63_RS04950	COG1873	PFAM PRC-barrel domain
BR63_RS04965	COG0612	Peptidase, M16
BR63_RS04970	COG1686	Belongs to the peptidase S11 family
BR63_RS04975	COG0726	polysaccharide deacetylase
BR63_RS04980	COG1185	polyribonucleotide nucleotidyltransferase activity
BR63_RS04985	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BR63_RS05000	COG0196	riboflavin kinase activity
BR63_RS05005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BR63_RS05010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BR63_RS05015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BR63_RS05020	COG3064	Membrane
BR63_RS05020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BR63_RS05020	COG3064	Membrane
BR63_RS05020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BR63_RS05030	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BR63_RS05035	COG0195	Participates in both transcription termination and antitermination
BR63_RS05040	COG0779	Required for maturation of 30S ribosomal subunits
BR63_RS05050	COG1285	pathogenesis
BR63_RS05055	COG0463	Glycosyl transferase, family 2
BR63_RS05060	COG0442	prolyl-tRNA aminoacylation
BR63_RS05065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BR63_RS05070	COG0750	zinc metalloprotease
BR63_RS05075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BR63_RS05080	COG0628	permease
BR63_RS05085	COG4589	Belongs to the CDS family
BR63_RS05100	COG0233	cytoplasmic translational termination
BR63_RS05105	COG0528	UMP kinase activity
BR63_RS05110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BR63_RS05115	COG0052	Belongs to the universal ribosomal protein uS2 family
BR63_RS05135	COG1191	sigma factor activity
BR63_RS05140	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BR63_RS05145	COG1776	CheC inhibitor of MCP methylation
BR63_RS05150	COG0835	chemotaxis
BR63_RS05155	COG0643	Histidine kinase
BR63_RS05155	COG2198	Histidine kinase
BR63_RS05160	COG2201	protein-glutamate methylesterase activity
BR63_RS05175	COG1419	protein localization to endoplasmic reticulum
BR63_RS05180	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BR63_RS05185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BR63_RS05190	COG1684	flagellar biosynthetic protein fliR
BR63_RS05195	COG1987	bacterial-type flagellum assembly
BR63_RS05200	COG1338	Plays a role in the flagellum-specific transport system
BR63_RS05205	COG3190	flagellar
BR63_RS05210	COG2201	protein-glutamate methylesterase activity
BR63_RS05215	COG1776	CheC inhibitor of MCP methylation
BR63_RS05215	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BR63_RS05220	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BR63_RS05225	COG1580	Controls the rotational direction of flagella during chemotaxis
BR63_RS05240	COG1582	Flagellar protein (FlbD)
BR63_RS05255	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BR63_RS05275	COG1157	protein secretion by the type III secretion system
BR63_RS05285	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BR63_RS05290	COG1766	The M ring may be actively involved in energy transduction
BR63_RS05295	COG1677	Flagellar hook-basal body complex protein FliE
BR63_RS05300	COG1558	bacterial-type flagellum-dependent cell motility
BR63_RS05305	COG1815	bacterial-type flagellum-dependent cell motility
BR63_RS05315	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BR63_RS05320	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BR63_RS05325	COG4974	Belongs to the 'phage' integrase family
BR63_RS05330	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BR63_RS05335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BR63_RS05340	COG0758	DNA mediated transformation
BR63_RS05345	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BR63_RS05360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BR63_RS05380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BR63_RS05385	COG2244	polysaccharide biosynthetic process
BR63_RS05390	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BR63_RS05405	COG0302	gtp cyclohydrolase
BR63_RS05430	COG1183	phosphatidylcholine synthase activity
BR63_RS05435	COG0688	phosphatidylethanolamine metabolic process
BR63_RS05440	COG1199	ATP-dependent helicase activity
BR63_RS05440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BR63_RS05445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BR63_RS05455	COG1694	Mazg nucleotide pyrophosphohydrolase
BR63_RS05475	COG2223	nitrite transmembrane transporter activity
BR63_RS05485	COG2257	FlhB HrpN YscU SpaS Family
BR63_RS05495	COG1307	EDD domain protein, DegV family
BR63_RS05500	COG1461	Dihydroxyacetone kinase
BR63_RS05510	COG0735	belongs to the Fur family
BR63_RS05520	COG0569	domain protein
BR63_RS05525	COG2827	Endonuclease containing a URI domain
BR63_RS05530	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BR63_RS05535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BR63_RS05535	COG2199	diguanylate cyclase activity
BR63_RS05550	COG1361	Conserved repeat domain
BR63_RS05580	COG0425	Belongs to the sulfur carrier protein TusA family
BR63_RS05615	COG3409	Peptidoglycan-binding domain 1 protein
BR63_RS05615	COG5632	N-Acetylmuramoyl-L-alanine amidase
BR63_RS05640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BR63_RS05750	COG0305	Participates in initiation and elongation during chromosome replication
BR63_RS05835	COG3620	sequence-specific DNA binding
BR63_RS05845	COG2856	Zn peptidase
BR63_RS05915	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BR63_RS05920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BR63_RS05925	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BR63_RS05930	COG0113	porphobilinogen synthase activity
BR63_RS05940	COG0181	hydroxymethylbilane synthase activity
BR63_RS05945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BR63_RS05950	COG1648	precorrin-2 dehydrogenase activity
BR63_RS05950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BR63_RS05965	COG0805	protein transport
BR63_RS05970	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BR63_RS05975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BR63_RS05985	COG0083	homoserine kinase activity
BR63_RS05990	COG0460	homoserine dehydrogenase
BR63_RS05995	COG4492	Belongs to the UPF0735 family
BR63_RS06000	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BR63_RS06005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BR63_RS06010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BR63_RS06065	COG1164	Oligoendopeptidase f
BR63_RS06070	COG0606	chelatase, subunit chli
BR63_RS06080	COG3875	lactate racemase activity
BR63_RS06090	COG0792	nuclease activity
BR63_RS06095	COG1007	ATP synthesis coupled electron transport
BR63_RS06105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BR63_RS06115	COG0839	Belongs to the complex I subunit 6 family
BR63_RS06120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BR63_RS06125	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BR63_RS06130	COG0649	NAD binding
BR63_RS06135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BR63_RS06145	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BR63_RS06160	COG0681	Belongs to the peptidase S26 family
BR63_RS06165	COG0335	large ribosomal subunit rRNA binding
BR63_RS06170	COG4752	Belongs to the RNA methyltransferase TrmD family
BR63_RS06170	COG0336	Belongs to the RNA methyltransferase TrmD family
BR63_RS06175	COG0336	Belongs to the RNA methyltransferase TrmD family
BR63_RS06180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BR63_RS06195	COG0228	four-way junction DNA binding
BR63_RS06200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BR63_RS06205	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BR63_RS06210	COG0402	S-adenosylhomocysteine deaminase activity
BR63_RS06220	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BR63_RS06225	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BR63_RS06230	COG0552	protein localization to endoplasmic reticulum
BR63_RS06235	COG1196	nuclear chromosome segregation
BR63_RS06245	COG0571	ribonuclease III activity
BR63_RS06250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BR63_RS06255	COG2070	2-Nitropropane dioxygenase
BR63_RS06260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BR63_RS06265	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_RS06270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BR63_RS06280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BR63_RS06285	COG0416	fatty acid biosynthetic process
BR63_RS06290	COG2030	dehydratase
BR63_RS06295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BR63_RS06305	COG0280	phosphate acetyltransferase
BR63_RS06315	COG1752	Esterase of the alpha-beta hydrolase superfamily
BR63_RS06320	COG3314	Sporulation integral membrane protein YlbJ
BR63_RS06330	COG0742	ribosomal rna small subunit methyltransferase
BR63_RS06340	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BR63_RS06360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BR63_RS06370	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BR63_RS06375	COG4770	biotin carboxylase activity
BR63_RS06385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BR63_RS06390	COG0346	lactoylglutathione lyase activity
BR63_RS06400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BR63_RS06400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BR63_RS06405	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BR63_RS06405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BR63_RS06415	COG0427	acetyl-CoA hydrolase
BR63_RS06435	COG0471	metal ion transport
BR63_RS06435	COG0490	domain, Protein
BR63_RS06445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BR63_RS06450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BR63_RS06460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BR63_RS06465	COG1162	GTPase activity
BR63_RS06470	COG2815	serine threonine protein kinase
BR63_RS06470	COG0515	serine threonine protein kinase
BR63_RS06475	COG0631	protein serine/threonine phosphatase activity
BR63_RS06485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BR63_RS06485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BR63_RS06490	COG2738	Putative neutral zinc metallopeptidase
BR63_RS06500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BR63_RS06505	COG0242	peptide deformylase activity
BR63_RS06510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BR63_RS06515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BR63_RS06520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BR63_RS06525	COG1758	RNA polymerase activity
BR63_RS06530	COG0194	GDP metabolic process
BR63_RS06535	COG2052	Domain of unknown function (DUF370)
BR63_RS06540	COG1561	YicC-like family, N-terminal region
BR63_RS06550	COG0409	Hydrogenase expression formation protein
BR63_RS06555	COG0298	carbon dioxide binding
BR63_RS06560	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BR63_RS06565	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BR63_RS06580	COG1151	hydroxylamine reductase activity
BR63_RS06590	COG0375	protein maturation
BR63_RS06600	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BR63_RS06610	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BR63_RS06615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BR63_RS06620	COG0651	ATP synthesis coupled electron transport
BR63_RS06635	COG0436	Aminotransferase
BR63_RS06640	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BR63_RS06645	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BR63_RS06670	COG0673	inositol 2-dehydrogenase activity
BR63_RS06680	COG1228	amidohydrolase
BR63_RS06690	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS06690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_RS06695	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS06710	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
BR63_RS06715	COG2964	Protein conserved in bacteria
BR63_RS06720	COG0492	ferredoxin-NADP+ reductase activity
BR63_RS06725	COG0446	pyridine nucleotide-disulphide oxidoreductase
BR63_RS06730	COG1797	cobyrinic acid a,c-diamide synthase activity
BR63_RS06735	COG2920	part of a sulfur-relay system
BR63_RS06740	COG0247	lactate metabolic process
BR63_RS06760	COG2221	Nitrite and sulphite reductase 4Fe-4S
BR63_RS06765	COG2221	Nitrite and sulphite reductase 4Fe-4S
BR63_RS06775	COG2197	response regulator
BR63_RS06780	COG4585	Histidine kinase
BR63_RS06785	COG1396	sequence-specific DNA binding
BR63_RS06790	COG0583	DNA-binding transcription factor activity
BR63_RS06795	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BR63_RS06800	COG0564	pseudouridine synthase activity
BR63_RS06810	COG0778	Nitroreductase
BR63_RS06825	COG2848	UPF0210 protein
BR63_RS06830	COG3830	Belongs to the UPF0237 family
BR63_RS06895	COG1402	creatininase
BR63_RS06900	COG0778	Nitroreductase
BR63_RS06910	COG4279	zinc finger
BR63_RS06915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BR63_RS06965	COG0010	Belongs to the arginase family
BR63_RS06970	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BR63_RS06985	COG0686	Belongs to the AlaDH PNT family
BR63_RS07010	COG0012	GTP binding
BR63_RS07020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BR63_RS07025	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BR63_RS07035	COG0398	Pfam SNARE associated Golgi protein
BR63_RS07040	COG2414	aldehyde ferredoxin oxidoreductase
BR63_RS07055	COG1074	ATP-dependent DNA helicase activity
BR63_RS07060	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BR63_RS07065	COG0440	acetolactate synthase activity
BR63_RS07070	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BR63_RS07100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BR63_RS07100	COG2080	2 iron, 2 sulfur cluster binding
BR63_RS07115	COG1342	Belongs to the UPF0251 family
BR63_RS07130	COG0446	pyridine nucleotide-disulphide oxidoreductase
BR63_RS07145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BR63_RS07150	COG2384	SAM-dependent methyltransferase
BR63_RS07175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BR63_RS07180	COG0358	DNA primase activity
BR63_RS07190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BR63_RS07190	COG0574	Belongs to the PEP-utilizing enzyme family
BR63_RS07195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BR63_RS07200	COG0517	IMP dehydrogenase activity
BR63_RS07205	COG1760	l-serine dehydratase
BR63_RS07210	COG1760	l-serine dehydratase
BR63_RS07215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BR63_RS07220	COG2030	dehydratase
BR63_RS07225	COG0751	glycine-tRNA ligase activity
BR63_RS07230	COG0752	glycyl-tRNA synthetase alpha subunit
BR63_RS07240	COG1381	Involved in DNA repair and RecF pathway recombination
BR63_RS07265	COG2197	response regulator
BR63_RS07270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BR63_RS07275	COG2239	Acts as a magnesium transporter
BR63_RS07285	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BR63_RS07305	COG1470	cell adhesion involved in biofilm formation
BR63_RS07320	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BR63_RS07330	COG1480	7TM receptor with intracellular HD hydrolase
BR63_RS07335	COG1702	phosphate starvation-inducible protein PhoH
BR63_RS07365	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BR63_RS07405	COG4864	UPF0365 protein
BR63_RS07430	COG0537	adenosine 5'-monophosphoramidase activity
BR63_RS07435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BR63_RS07440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BR63_RS07445	COG2264	protein methyltransferase activity
BR63_RS07450	COG0484	heat shock protein binding
BR63_RS07455	COG0443	Heat shock 70 kDa protein
BR63_RS07460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BR63_RS07465	COG0459	protein refolding
BR63_RS07470	COG1420	regulation of RNA biosynthetic process
BR63_RS07475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BR63_RS07480	COG0481	GTPase activity
BR63_RS07485	COG0728	peptidoglycan biosynthetic process
BR63_RS07515	COG3437	response regulator, receiver
BR63_RS07520	COG2202	Pas domain
BR63_RS07520	COG2205	protein histidine kinase activity
BR63_RS07525	COG2197	response regulator
BR63_RS07540	COG0268	Binds directly to 16S ribosomal RNA
BR63_RS07545	COG1466	dna polymerase III delta subunit
BR63_RS07550	COG1686	Belongs to the peptidase S11 family
BR63_RS07560	COG2333	competence protein COMEC
BR63_RS07560	COG0658	competence protein
BR63_RS07580	COG0495	leucyl-tRNA aminoacylation
BR63_RS07595	COG2801	Transposase and inactivated derivatives
BR63_RS07610	COG2226	methyltransferase
BR63_RS07615	COG0799	negative regulation of ribosome biogenesis
BR63_RS07620	COG1713	HD superfamily hydrolase involved in NAD metabolism
BR63_RS07625	COG0724	RNA recognition motif
BR63_RS07630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BR63_RS07635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BR63_RS07640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BR63_RS07645	COG1534	Rna-binding protein
BR63_RS07650	COG0577	efflux transmembrane transporter activity
BR63_RS07655	COG1136	(ABC) transporter
BR63_RS07665	COG1983	PspC domain protein
BR63_RS07670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BR63_RS07680	COG2011	ABC-type metal ion transport system permease component
BR63_RS07700	COG0840	transmembrane signaling receptor activity
BR63_RS07710	COG0569	domain protein
BR63_RS07715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BR63_RS07750	COG1151	hydroxylamine reductase activity
BR63_RS07755	COG0824	Thioesterase
BR63_RS07770	COG0163	prenyltransferase activity
BR63_RS07775	COG0521	Mo-molybdopterin cofactor biosynthetic process
BR63_RS07780	COG0315	cyclic pyranopterin monophosphate synthase activity
BR63_RS07785	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BR63_RS07790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BR63_RS07800	COG1910	domain protein
BR63_RS07805	COG0303	'Molybdopterin
BR63_RS07810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BR63_RS07835	COG1051	belongs to the nudix hydrolase family
BR63_RS07845	COG3706	GGDEF domain
BR63_RS07855	COG5632	N-Acetylmuramoyl-L-alanine amidase
BR63_RS07855	COG3409	Peptidoglycan-binding domain 1 protein
BR63_RS07860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BR63_RS07890	COG1942	4-Oxalocrotonate Tautomerase
BR63_RS07910	COG0697	spore germination
BR63_RS07925	COG2226	methyltransferase
BR63_RS07930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BR63_RS07935	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BR63_RS07945	COG1809	phosphosulfolactate synthase activity
BR63_RS07950	COG2045	Belongs to the ComB family
BR63_RS07975	COG3875	lactate racemase activity
BR63_RS07980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BR63_RS07985	COG0066	3-isopropylmalate dehydratase activity
BR63_RS07990	COG0179	Fumarylacetoacetate (FAA) hydrolase
BR63_RS07995	COG0398	Pfam SNARE associated Golgi protein
BR63_RS08005	COG2186	Transcriptional regulator
BR63_RS08015	COG2086	electron transfer activity
BR63_RS08020	COG1960	acyl-CoA dehydrogenase activity
BR63_RS08030	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_RS08030	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_RS08030	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BR63_RS08030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BR63_RS08035	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_RS08040	COG2086	electron transfer activity
BR63_RS08045	COG1960	acyl-CoA dehydrogenase activity
BR63_RS08050	COG3829	transcription factor binding
BR63_RS08050	COG3290	protein histidine kinase activity
BR63_RS08055	COG2205	protein histidine kinase activity
BR63_RS08060	COG0745	RESPONSE REGULATOR receiver
BR63_RS08070	COG3852	Histidine kinase
BR63_RS08075	COG2204	response regulator
BR63_RS08080	COG2031	fatty acid transporter
BR63_RS08085	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BR63_RS08095	COG0159	tryptophan synthase activity
BR63_RS08110	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BR63_RS08120	COG0584	glycerophosphoryl diester phosphodiesterase
BR63_RS08130	COG0395	ABC-type sugar transport system, permease component
BR63_RS08135	COG1175	transmembrane transport
BR63_RS08140	COG3842	ATPase activity
BR63_RS08150	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BR63_RS08160	COG0133	tryptophan synthase activity
BR63_RS08165	COG0135	phosphoribosylanthranilate isomerase activity
BR63_RS08175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BR63_RS08180	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BR63_RS08185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BR63_RS08185	COG0512	Glutamine amidotransferase of anthranilate synthase
BR63_RS08215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BR63_RS08220	COG3958	Transketolase
BR63_RS08225	COG3959	Transketolase, thiamine diphosphate binding domain
BR63_RS08230	COG0745	RESPONSE REGULATOR receiver
BR63_RS08240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BR63_RS08275	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BR63_RS08280	COG3246	L-lysine catabolic process to acetate
BR63_RS08285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BR63_RS08290	COG2358	TRAP transporter, solute receptor (TAXI family
BR63_RS08300	COG2358	TRAP transporter, solute receptor (TAXI family
BR63_RS08335	COG1242	4 iron, 4 sulfur cluster binding
BR63_RS08350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS08355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_RS08360	COG0167	dihydroorotate dehydrogenase activity
BR63_RS08365	COG0543	2 iron, 2 sulfur cluster binding
BR63_RS08370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BR63_RS08375	COG2508	Transcriptional regulator
BR63_RS08380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BR63_RS08385	COG0284	orotidine-5'-phosphate decarboxylase activity
BR63_RS08390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BR63_RS08395	COG0505	Belongs to the CarA family
BR63_RS08400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BR63_RS08405	COG0540	Belongs to the ATCase OTCase family
BR63_RS08415	COG1942	4-Oxalocrotonate Tautomerase
BR63_RS08435	COG2414	aldehyde ferredoxin oxidoreductase
BR63_RS08440	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BR63_RS08465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_RS08470	COG1063	alcohol dehydrogenase
BR63_RS08475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BR63_RS08480	COG1882	Formate acetyltransferase
BR63_RS08485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS08485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_RS08490	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS08490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_RS08500	COG3275	phosphorelay sensor kinase activity
BR63_RS08505	COG3279	Response regulator of the LytR AlgR family
BR63_RS08515	COG1966	Carbon starvation protein
BR63_RS08520	COG2814	Major facilitator Superfamily
BR63_RS08540	COG0640	Transcriptional regulator
BR63_RS08555	COG1924	4 iron, 4 sulfur cluster binding
BR63_RS08580	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BR63_RS08585	COG1666	GTP binding
BR63_RS08605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BR63_RS08615	COG2323	membrane
BR63_RS08625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BR63_RS08645	COG5564	TIM-barrel signal transduction protein
BR63_RS08655	COG2204	response regulator
BR63_RS08660	COG0800	Aldolase
BR63_RS08665	COG1063	alcohol dehydrogenase
BR63_RS08670	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_RS08675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BR63_RS08680	COG0129	dihydroxy-acid dehydratase activity
BR63_RS08685	COG1070	Carbohydrate kinase
BR63_RS08690	COG1737	Transcriptional regulator
BR63_RS08695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_RS08700	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS08705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_RS08715	COG0459	protein refolding
BR63_RS08720	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BR63_RS08725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BR63_RS08730	COG3328	transposase activity
BR63_RS08745	COG5609	conserved protein (DUF2294)
BR63_RS08750	COG2223	nitrite transmembrane transporter activity
BR63_RS08755	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BR63_RS08765	COG1454	alcohol dehydrogenase
BR63_RS08765	COG1012	belongs to the aldehyde dehydrogenase family
BR63_RS08775	COG5001	Diguanylate cyclase
BR63_RS08775	COG3300	MHYT domain
BR63_RS08790	COG5001	Diguanylate cyclase
BR63_RS08790	COG3300	MHYT domain
BR63_RS08815	COG1366	Belongs to the anti-sigma-factor antagonist family
BR63_RS08825	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BR63_RS08860	COG0277	FAD linked oxidase domain protein
BR63_RS08870	COG0277	FAD linked oxidase domain protein
BR63_RS08875	COG0471	metal ion transport
BR63_RS08880	COG3279	Response regulator of the LytR AlgR family
BR63_RS08885	COG3275	phosphorelay sensor kinase activity
BR63_RS08940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BR63_RS08955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BR63_RS08970	COG1473	amidohydrolase
BR63_RS08980	COG0277	FAD linked oxidase domain protein
BR63_RS08985	COG0247	lactate metabolic process
BR63_RS09000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BR63_RS09015	COG4942	peptidase
BR63_RS09020	COG0428	transporter
BR63_RS09030	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BR63_RS09030	COG2199	diguanylate cyclase activity
BR63_RS09040	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
BR63_RS09045	COG0310	cobalt ion transport
BR63_RS09050	COG0803	Belongs to the bacterial solute-binding protein 9 family
BR63_RS09055	COG1121	(ABC) transporter
BR63_RS09060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BR63_RS09080	COG1024	Enoyl-CoA hydratase
BR63_RS09085	COG0443	Heat shock 70 kDa protein
BR63_RS09090	COG0484	heat shock protein binding
BR63_RS09100	COG0542	response to heat
BR63_RS09115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BR63_RS09125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BR63_RS09140	COG3608	succinylglutamate desuccinylase aspartoacylase
BR63_RS09140	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BR63_RS09180	COG2414	aldehyde ferredoxin oxidoreductase
BR63_RS09195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BR63_RS09205	COG2267	carboxylic ester hydrolase activity
BR63_RS09210	COG0519	Catalyzes the synthesis of GMP from XMP
BR63_RS09215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BR63_RS09240	COG2233	PERMEase
BR63_RS09255	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BR63_RS09260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BR63_RS09265	COG0549	Belongs to the carbamate kinase family
BR63_RS09275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BR63_RS09280	COG1304	FMN binding
BR63_RS09285	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BR63_RS09295	COG2508	Transcriptional regulator
BR63_RS09305	COG1546	Belongs to the CinA family
BR63_RS09305	COG1058	Belongs to the CinA family
BR63_RS09310	COG3608	succinylglutamate desuccinylase aspartoacylase
BR63_RS09310	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BR63_RS09325	COG1187	pseudouridine synthase activity
BR63_RS09330	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BR63_RS09330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BR63_RS09335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BR63_RS09380	COG2059	Chromate
BR63_RS09385	COG2861	carbohydrate metabolic process
BR63_RS09390	COG4149	molybdate abc transporter
BR63_RS09395	COG0725	ABC transporter, periplasmic molybdate-binding protein
BR63_RS09415	COG0697	spore germination
BR63_RS09450	COG0151	Belongs to the GarS family
BR63_RS09455	COG0138	bifunctional purine biosynthesis protein purh
BR63_RS09460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BR63_RS09470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BR63_RS09475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BR63_RS09480	COG0047	phosphoribosylformylglycinamidine synthase activity
BR63_RS09485	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BR63_RS09490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BR63_RS09495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BR63_RS09505	COG2252	PERMEase
BR63_RS09520	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_RS09525	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_RS09540	COG1414	Transcriptional regulator
BR63_RS09550	COG0157	Belongs to the NadC ModD family
BR63_RS09560	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BR63_RS09565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BR63_RS09565	COG0519	Catalyzes the synthesis of GMP from XMP
BR63_RS09570	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BR63_RS09575	COG2855	membrane
BR63_RS09580	COG1309	transcriptional regulator
BR63_RS09585	COG0842	Transport permease protein
BR63_RS09590	COG1131	(ABC) transporter
BR63_RS09595	COG1131	(ABC) transporter
BR63_RS09605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BR63_RS09615	COG3949	Membrane
BR63_RS09620	COG3829	transcription factor binding
BR63_RS09635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BR63_RS09660	COG0658	competence protein
BR63_RS09660	COG2333	competence protein COMEC
BR63_RS09665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BR63_RS09670	COG0321	lipoyl(octanoyl) transferase activity
BR63_RS09685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BR63_RS09700	COG0247	lactate metabolic process
BR63_RS09710	COG2920	part of a sulfur-relay system
BR63_RS09715	COG2204	response regulator
BR63_RS09720	COG1342	Belongs to the UPF0251 family
BR63_RS09735	COG0489	protein tyrosine kinase activity
BR63_RS09740	COG2894	cell division
BR63_RS09760	COG0517	IMP dehydrogenase activity
BR63_RS09765	COG0840	transmembrane signaling receptor activity
BR63_RS09780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BR63_RS09790	COG0459	protein refolding
BR63_RS09795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BR63_RS09800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BR63_RS09805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BR63_RS09810	COG0251	oxidation-reduction process
BR63_RS09830	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BR63_RS09840	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_RS09860	COG0456	acetyltransferase
BR63_RS09865	COG1214	PFAM Peptidase M22, glycoprotease
BR63_RS09870	COG0802	atpase or kinase
BR63_RS09875	COG2204	response regulator
BR63_RS09880	COG1228	amidohydrolase
BR63_RS09890	COG2183	response to ionizing radiation
BR63_RS09900	COG2337	Toxic component of a toxin-antitoxin (TA) module
BR63_RS09905	COG0864	Transcriptional regulator
BR63_RS09910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BR63_RS09915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BR63_RS09915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BR63_RS09920	COG0736	holo-[acyl-carrier-protein] synthase activity
BR63_RS09925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BR63_RS09935	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BR63_RS09945	COG3856	small basic protein
BR63_RS09960	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
BR63_RS09975	COG0739	heme binding
BR63_RS09985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BR63_RS10015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_RS10015	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS10020	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS10025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_RS10030	COG3290	protein histidine kinase activity
BR63_RS10030	COG3829	transcription factor binding
BR63_RS10045	COG0277	FAD linked oxidase domain protein
BR63_RS10060	COG1454	alcohol dehydrogenase
BR63_RS10090	COG0427	acetyl-CoA hydrolase
BR63_RS10100	COG3290	protein histidine kinase activity
BR63_RS10100	COG3829	transcription factor binding
BR63_RS10130	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_RS10160	COG0473	3-isopropylmalate dehydrogenase activity
BR63_RS10165	COG0066	3-isopropylmalate dehydratase activity
BR63_RS10170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BR63_RS10175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BR63_RS10180	COG0028	Belongs to the TPP enzyme family
BR63_RS10190	COG0440	acetolactate synthase activity
BR63_RS10195	COG0028	Belongs to the TPP enzyme family
BR63_RS10200	COG0129	dihydroxy-acid dehydratase activity
BR63_RS10220	COG1704	LemA family
BR63_RS10230	COG2937	Belongs to the GPAT DAPAT family
BR63_RS10235	COG2155	Conserved Protein
BR63_RS10245	COG0746	molybdenum cofactor guanylyltransferase activity
BR63_RS10250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BR63_RS10260	COG0494	nUDIX hydrolase
BR63_RS10265	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BR63_RS10275	COG3260	NADH ubiquinone oxidoreductase 20
BR63_RS10280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BR63_RS10285	COG3261	NADH dehydrogenase
BR63_RS10285	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
BR63_RS10290	COG0651	ATP synthesis coupled electron transport
BR63_RS10295	COG4237	Hydrogenase 4 membrane
BR63_RS10300	COG0650	Formate hydrogenlyase subunit 4
BR63_RS10305	COG0651	ATP synthesis coupled electron transport
BR63_RS10310	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BR63_RS10320	COG2116	formate transmembrane transporter activity
BR63_RS10325	COG0288	reversible hydration of carbon dioxide
BR63_RS10340	COG2204	response regulator
BR63_RS10355	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BR63_RS10365	COG1331	Highly conserved protein containing a thioredoxin domain
BR63_RS10385	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BR63_RS10390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BR63_RS10395	COG0500	methyltransferase
BR63_RS10415	COG1429	ligase activity, forming nitrogen-metal bonds
BR63_RS10435	COG1131	(ABC) transporter
BR63_RS10440	COG1131	(ABC) transporter
BR63_RS10445	COG1120	ATPase activity
BR63_RS10505	COG1396	sequence-specific DNA binding
BR63_RS10510	COG0840	transmembrane signaling receptor activity
BR63_RS10520	COG0116	Belongs to the methyltransferase superfamily
BR63_RS10550	COG3259	Nickel-dependent hydrogenase
BR63_RS10560	COG0375	protein maturation
BR63_RS10565	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BR63_RS10570	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BR63_RS10575	COG0298	carbon dioxide binding
BR63_RS10585	COG0309	Hydrogenase expression formation protein (HypE)
BR63_RS10600	COG0095	Lipoate-protein ligase
BR63_RS10620	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_RS10630	COG0280	phosphate acetyltransferase
BR63_RS10635	COG3426	butyrate kinase activity
BR63_RS10640	COG1414	Transcriptional regulator
BR63_RS10650	COG2962	Rard protein
BR63_RS10655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BR63_RS10685	COG3275	phosphorelay sensor kinase activity
BR63_RS10690	COG3279	Response regulator of the LytR AlgR family
BR63_RS10695	COG1966	Carbon starvation protein
BR63_RS10700	COG5002	protein histidine kinase activity
BR63_RS10705	COG0745	RESPONSE REGULATOR receiver
BR63_RS10710	COG2226	methyltransferase
BR63_RS10725	COG1250	3-hydroxyacyl-CoA dehydrogenase
BR63_RS10730	COG2030	dehydratase
BR63_RS10735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_RS10740	COG2086	electron transfer activity
BR63_RS10745	COG1960	acyl-CoA dehydrogenase activity
BR63_RS10750	COG0183	Belongs to the thiolase family
BR63_RS10760	COG0644	oxidoreductase
BR63_RS10765	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_RS10775	COG1960	acyl-CoA dehydrogenase activity
BR63_RS10780	COG0427	acetyl-CoA hydrolase
BR63_RS10795	COG3290	protein histidine kinase activity
BR63_RS10795	COG3829	transcription factor binding
BR63_RS10800	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_RS10800	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS10810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_RS10825	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BR63_RS10840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BR63_RS10855	COG2210	Belongs to the sulfur carrier protein TusA family
BR63_RS10870	COG2608	mercury ion transmembrane transporter activity
BR63_RS10875	COG2217	Heavy metal translocating P-type atpase
BR63_RS10890	COG2738	Putative neutral zinc metallopeptidase
BR63_RS10910	COG0785	Cytochrome C biogenesis protein
BR63_RS10925	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BR63_RS10925	COG2199	diguanylate cyclase activity
BR63_RS10935	COG0745	RESPONSE REGULATOR receiver
BR63_RS10940	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
BR63_RS10945	COG0409	Hydrogenase expression formation protein
BR63_RS10950	COG0298	carbon dioxide binding
BR63_RS10955	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BR63_RS10960	COG0805	protein transport
BR63_RS10965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BR63_RS10970	COG0805	protein transport
BR63_RS10980	COG0375	protein maturation
BR63_RS10985	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BR63_RS11005	COG1191	sigma factor activity
BR63_RS11025	COG5002	protein histidine kinase activity
BR63_RS11045	COG0730	response to heat
BR63_RS11060	COG1846	Transcriptional regulator
BR63_RS11070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BR63_RS11080	COG1840	ABC-type Fe3 transport system, periplasmic component
BR63_RS11085	COG1178	ABC-type Fe3 transport system permease component
BR63_RS11110	COG3852	Histidine kinase
BR63_RS11115	COG2204	response regulator
BR63_RS11125	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BR63_RS11130	COG1914	H( )-stimulated, divalent metal cation uptake system
BR63_RS11135	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BR63_RS11140	COG1984	allophanate hydrolase subunit 2
BR63_RS11145	COG4336	lyase activity
BR63_RS11150	COG1079	Belongs to the binding-protein-dependent transport system permease family
BR63_RS11155	COG4603	Belongs to the binding-protein-dependent transport system permease family
BR63_RS11160	COG3845	ABC transporter
BR63_RS11165	COG1744	ABC transporter substrate-binding protein PnrA-like
BR63_RS11170	COG1592	Rubrerythrin
BR63_RS11170	COG1773	rubredoxin
BR63_RS11175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BR63_RS11180	COG0745	RESPONSE REGULATOR receiver
BR63_RS11190	COG1272	protein, Hemolysin III
BR63_RS11200	COG0739	heme binding
BR63_RS11310	COG1484	DNA-dependent DNA replication
BR63_RS11325	COG3723	Recombinational DNA repair protein, rece pathway
BR63_RS11390	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BR63_RS11395	COG0557	exoribonuclease II activity
BR63_RS11410	COG1647	Serine aminopeptidase, S33
BR63_RS11415	COG0667	Aldo Keto reductase
BR63_RS11420	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BR63_RS11425	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BR63_RS11430	COG0148	phosphopyruvate hydratase activity
BR63_RS11435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BR63_RS11440	COG0149	triose-phosphate isomerase activity
BR63_RS11445	COG0126	phosphoglycerate kinase activity
BR63_RS11460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BR63_RS11470	COG0110	maltose O-acetyltransferase activity
BR63_RS11475	COG2221	Nitrite and sulphite reductase 4Fe-4S
BR63_RS11485	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BR63_RS11490	COG1660	Displays ATPase and GTPase activities
BR63_RS11495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BR63_RS11500	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BR63_RS11505	COG1473	amidohydrolase
BR63_RS11510	COG1619	proteins homologs of microcin C7 resistance protein MccF
BR63_RS11525	COG1950	PFAM Membrane protein of
BR63_RS11530	COG0322	excinuclease ABC activity
BR63_RS11535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BR63_RS11540	COG0556	nucleotide-excision repair
BR63_RS11555	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
BR63_RS11570	COG0793	Belongs to the peptidase S41A family
BR63_RS11580	COG2177	Part of the ABC transporter FtsEX involved in
BR63_RS11585	COG2884	Cell division ATP-binding protein ftsE
BR63_RS11590	COG3958	Transketolase
BR63_RS11595	COG3959	Transketolase, thiamine diphosphate binding domain
BR63_RS11600	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BR63_RS11605	COG0653	protein targeting
BR63_RS11615	COG1278	Cold shock
BR63_RS11625	COG0765	amino acid transport
BR63_RS11640	COG1516	flagellar protein fliS
BR63_RS11645	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BR63_RS11675	COG3693	PFAM glycoside hydrolase, family 10
BR63_RS11680	COG1191	sigma factor activity
BR63_RS11705	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BR63_RS11710	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BR63_RS11725	COG1256	bacterial-type flagellum assembly
BR63_RS11725	COG4786	Flagellar basal body rod
BR63_RS11785	COG2197	response regulator
BR63_RS11840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BR63_RS11855	COG0277	FAD linked oxidase domain protein
BR63_RS11865	COG0129	dihydroxy-acid dehydratase activity
BR63_RS11880	COG2721	sulfolactate sulfo-lyase activity
BR63_RS11885	COG2721	sulfolactate sulfo-lyase activity
BR63_RS11890	COG2414	aldehyde ferredoxin oxidoreductase
BR63_RS11900	COG2186	Transcriptional regulator
BR63_RS11905	COG1063	alcohol dehydrogenase
BR63_RS11910	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_RS11915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BR63_RS11925	COG0022	dehydrogenase e1 component
BR63_RS11930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BR63_RS11935	COG0247	lactate metabolic process
BR63_RS11940	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
BR63_RS11945	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BR63_RS11950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BR63_RS11955	COG2414	aldehyde ferredoxin oxidoreductase
BR63_RS11980	COG0395	ABC-type sugar transport system, permease component
BR63_RS11985	COG1175	transmembrane transport
BR63_RS11990	COG1653	transport
BR63_RS11995	COG3842	ATPase activity
BR63_RS12000	COG2188	Transcriptional regulator
BR63_RS12095	COG1309	transcriptional regulator
BR63_RS12100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BR63_RS12110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BR63_RS12135	COG0860	N-Acetylmuramoyl-L-alanine amidase
BR63_RS12135	COG4991	sh3 domain protein
BR63_RS12135	COG3103	Sh3 type 3 domain protein
BR63_RS12140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BR63_RS12145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BR63_RS12170	COG0726	polysaccharide deacetylase
BR63_RS12175	COG3634	alkyl hydroperoxide reductase activity
BR63_RS12220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BR63_RS12230	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BR63_RS12275	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_RS12300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BR63_RS12305	COG2089	acid synthase
BR63_RS12310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BR63_RS12315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BR63_RS12320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BR63_RS12335	COG0673	inositol 2-dehydrogenase activity
BR63_RS12365	COG1316	TRANSCRIPTIONal
BR63_RS12370	COG1316	TRANSCRIPTIONal
BR63_RS12410	COG4786	Flagellar basal body rod
BR63_RS12420	COG1609	Transcriptional regulator
BR63_RS12440	COG2385	sporulation resulting in formation of a cellular spore
BR63_RS12445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BR63_RS12460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BR63_RS12465	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BR63_RS12475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BR63_RS12480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BR63_RS12485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BR63_RS12490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BR63_RS12495	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BR63_RS12500	COG0356	it plays a direct role in the translocation of protons across the membrane
BR63_RS12515	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BR63_RS12525	COG2131	deaminase
BR63_RS12535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BR63_RS12540	COG4475	Protein of unknown function (DUF436)
BR63_RS12545	COG0698	ribose 5-phosphate isomerase
BR63_RS12555	COG1971	Probably functions as a manganese efflux pump
BR63_RS12560	COG0009	L-threonylcarbamoyladenylate synthase
BR63_RS12565	COG0651	ATP synthesis coupled electron transport
BR63_RS12575	COG0651	ATP synthesis coupled electron transport
BR63_RS12580	COG0651	ATP synthesis coupled electron transport
BR63_RS12595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BR63_RS12595	COG2111	Na H antiporter
BR63_RS12615	COG1863	multisubunit Na H antiporter MnhE subunit
BR63_RS12625	COG2890	protein-(glutamine-N5) methyltransferase activity
BR63_RS12630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BR63_RS12635	COG3872	metal-dependent enzyme
BR63_RS12640	COG0254	rRNA binding
BR63_RS12650	COG1494	fructose-1,6-bisphosphatase
BR63_RS12655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BR63_RS12670	COG2204	response regulator
BR63_RS12675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BR63_RS12680	COG2348	transferase activity, transferring amino-acyl groups
BR63_RS12685	COG0504	CTP synthase activity
BR63_RS12695	COG0018	arginyl-trna synthetase
BR63_RS12700	COG2959	enzyme of heme biosynthesis
BR63_RS12720	COG2855	membrane
BR63_RS12750	COG0728	peptidoglycan biosynthetic process
BR63_RS12755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BR63_RS12760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BR63_RS12765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BR63_RS12770	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BR63_RS12775	COG0297	glycogen (starch) synthase activity
BR63_RS12785	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BR63_RS12785	COG0662	Cupin 2, conserved barrel domain protein
BR63_RS12790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BR63_RS12810	COG0489	protein tyrosine kinase activity
BR63_RS12870	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BR63_RS12880	COG0456	acetyltransferase
BR63_RS12885	COG3153	acetyltransferase
BR63_RS12885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BR63_RS12895	COG1078	dGTPase activity
BR63_RS12900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BR63_RS12910	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BR63_RS12920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BR63_RS12925	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BR63_RS12945	COG0492	ferredoxin-NADP+ reductase activity
BR63_RS12950	COG1832	CoA-binding protein
BR63_RS12955	COG0739	heme binding
BR63_RS12955	COG0741	lytic transglycosylase activity
BR63_RS12955	COG1196	nuclear chromosome segregation
BR63_RS13000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BR63_RS13005	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BR63_RS13010	COG0305	Participates in initiation and elongation during chromosome replication
BR63_RS13015	COG1067	ATP-dependent peptidase activity
BR63_RS13015	COG0470	DNA polymerase III
BR63_RS13020	COG0359	binds to the 23S rRNA
BR63_RS13025	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BR63_RS13030	COG4241	membrane
BR63_RS13040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BR63_RS13060	COG0668	transmembrane transport
BR63_RS13085	COG0573	inorganic phosphate transmembrane transporter activity
BR63_RS13090	COG0573	inorganic phosphate transmembrane transporter activity
BR63_RS13095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BR63_RS13105	COG3949	Membrane
BR63_RS13115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BR63_RS13130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BR63_RS13145	COG5298	Protein conserved in bacteria
BR63_RS13150	COG1501	Belongs to the glycosyl hydrolase 31 family
BR63_RS13170	COG2223	nitrite transmembrane transporter activity
BR63_RS13175	COG0445	tRNA wobble uridine modification
BR63_RS13185	COG0546	phosphoglycolate phosphatase activity
BR63_RS13190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BR63_RS13195	COG1737	Transcriptional regulator
BR63_RS13205	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BR63_RS13210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BR63_RS13230	COG2707	UPF0756 membrane protein
BR63_RS13235	COG1307	EDD domain protein, DegV family
BR63_RS13255	COG1079	Belongs to the binding-protein-dependent transport system permease family
BR63_RS13265	COG3845	ABC transporter
BR63_RS13275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BR63_RS13325	COG1802	Transcriptional regulator
BR63_RS13330	COG2414	aldehyde ferredoxin oxidoreductase
BR63_RS13365	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_RS13380	COG4948	Mandelate Racemase Muconate Lactonizing
BR63_RS13395	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BR63_RS13410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BR63_RS13435	COG3949	Membrane
BR63_RS13455	COG0739	heme binding
BR63_RS13470	COG1811	Na channel or pump
BR63_RS13495	COG1475	DNA binding
BR63_RS13500	COG1192	Involved in chromosome partitioning
BR63_RS13510	COG0357	Ribosomal RNA small subunit methyltransferase G
BR63_RS13515	COG0445	tRNA wobble uridine modification
BR63_RS13520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BR63_RS13525	COG1847	R3H domain protein
BR63_RS13530	COG0706	membrane insertase activity
BR63_RS13535	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BR63_RS13550	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BR63_RS13560	COG0592	DNA-directed DNA polymerase activity
BR63_RS13565	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BR63_RS13575	COG0187	DNA topoisomerase II activity
BR63_RS13580	COG2204	response regulator
BR63_RS13585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BR63_RS13595	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BR63_RS13605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BR63_RS13610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BR63_RS13635	COG0590	tRNA wobble adenosine to inosine editing
BR63_RS13665	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
BR63_RS13710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BR63_RS13715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BR63_RS13720	COG0402	S-adenosylhomocysteine deaminase activity
BR63_RS13725	COG1609	Transcriptional regulator
BR63_RS13750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BR63_RS13755	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BR63_RS13760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BR63_RS13825	COG1982	Orn Lys Arg decarboxylase major
BR63_RS13830	COG3870	Protein conserved in bacteria
BR63_RS13840	COG0470	DNA polymerase III
BR63_RS13845	COG1774	PSP1 C-terminal conserved region
BR63_RS13855	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BR63_RS13860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BR63_RS13865	COG2002	toxin-antitoxin pair type II binding
BR63_RS13870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BR63_RS13870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BR63_RS13875	COG0084	hydrolase, TatD family'
BR63_RS13880	COG3583	domain protein
BR63_RS13880	COG3584	3D domain protein
BR63_RS13890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BR63_RS13895	COG3773	Cell wall hydrolase
BR63_RS13895	COG3409	Peptidoglycan-binding domain 1 protein
BR63_RS13910	COG4466	Protein conserved in bacteria
BR63_RS13915	COG2340	Cysteine-rich secretory protein family
BR63_RS13940	COG1376	ErfK ybiS ycfS ynhG family protein
BR63_RS13950	COG0704	Plays a role in the regulation of phosphate uptake
BR63_RS13955	COG0011	TIGRFAM Protein of
BR63_RS13970	COG2720	vancomycin resistance protein
BR63_RS13980	COG1404	Belongs to the peptidase S8 family
BR63_RS13985	COG1470	cell adhesion involved in biofilm formation
BR63_RS13990	COG0726	polysaccharide deacetylase
BR63_RS13995	COG0328	RNA-DNA hybrid ribonuclease activity
BR63_RS14010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BR63_RS14015	COG0765	amino acid transport
BR63_RS14035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BR63_RS14040	COG1869	D-ribose catabolic process
BR63_RS14045	COG1129	ABC transporter
BR63_RS14050	COG1172	Belongs to the binding-protein-dependent transport system permease family
BR63_RS14055	COG1879	ABC-type sugar transport system periplasmic component
BR63_RS14070	COG3546	catalase activity
BR63_RS14085	COG1794	racemase activity, acting on amino acids and derivatives
BR63_RS14100	COG0583	DNA-binding transcription factor activity
BR63_RS14110	COG1301	dicarboxylic acid transport
BR63_RS14115	COG0069	glutamate synthase activity
BR63_RS14130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BR63_RS14135	COG0022	dehydrogenase e1 component
BR63_RS14140	COG3199	ATP-NAD kinase
BR63_RS14145	COG0508	dehydrogenase complex catalyzes the overall conversion of
BR63_RS14150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BR63_RS14165	COG0189	ligase activity
BR63_RS14180	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BR63_RS14185	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BR63_RS14190	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BR63_RS14195	COG0512	Glutamine amidotransferase of anthranilate synthase
BR63_RS14215	COG1737	Transcriptional regulator
BR63_RS14220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_RS14225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_RS14225	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS14230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_RS14230	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS14255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BR63_RS14260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BR63_RS14260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BR63_RS14270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BR63_RS14270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BR63_RS14285	COG2076	Multidrug Resistance protein
BR63_RS14300	COG1695	Transcriptional regulator
BR63_RS14305	COG0640	Transcriptional regulator
BR63_RS14310	COG2217	Heavy metal translocating P-type atpase
BR63_RS14320	COG0017	Asparaginyl-tRNA synthetase
BR63_RS14325	COG5002	protein histidine kinase activity
BR63_RS14330	COG1217	gtp-binding protein TYPA
BR63_RS14345	COG1757	Na H antiporter
BR63_RS14350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BR63_RS14360	COG4242	Belongs to the peptidase S51 family
BR63_RS14365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BR63_RS14365	COG0189	ligase activity
BR63_RS14370	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BR63_RS14375	COG1802	Transcriptional regulator
BR63_RS14385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BR63_RS14390	COG2088	sporulation resulting in formation of a cellular spore
BR63_RS14395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BR63_RS14400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BR63_RS14405	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BR63_RS14410	COG0193	aminoacyl-tRNA hydrolase activity
BR63_RS14425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BR63_RS14435	COG2002	toxin-antitoxin pair type II binding
BR63_RS14440	COG2244	polysaccharide biosynthetic process
BR63_RS14445	COG3956	TIGRFAM MazG family protein
BR63_RS14460	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BR63_RS14465	COG2385	sporulation resulting in formation of a cellular spore
BR63_RS14495	COG1098	S1 RNA binding domain
BR63_RS14540	COG2208	phosphoserine phosphatase activity
BR63_RS14550	COG0037	tRNA processing
BR63_RS14560	COG0105	UTP biosynthetic process
BR63_RS14570	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BR63_RS14575	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BR63_RS14580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BR63_RS14585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BR63_RS14585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BR63_RS14595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BR63_RS14600	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BR63_RS14605	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BR63_RS14615	COG4684	Psort location CytoplasmicMembrane, score
BR63_RS14625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BR63_RS14645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BR63_RS14650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BR63_RS14685	COG4463	regulation of RNA biosynthetic process
BR63_RS14695	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BR63_RS14700	COG0542	response to heat
BR63_RS14705	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BR63_RS14715	COG1329	Transcriptional regulator
BR63_RS14720	COG4956	integral membrane protein (PIN domain superfamily)
BR63_RS14725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BR63_RS14730	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BR63_RS14735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BR63_RS14740	COG1045	serine acetyltransferase
BR63_RS14745	COG0215	cysteine-tRNA ligase activity
BR63_RS14755	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
BR63_RS14760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BR63_RS14765	COG3688	RNA-binding protein containing a PIN domain
BR63_RS14800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BR63_RS14805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BR63_RS14810	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BR63_RS14815	COG0250	Participates in transcription elongation, termination and antitermination
BR63_RS14820	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BR63_RS14825	COG0081	regulation of translation
BR63_RS14830	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BR63_RS14835	COG0222	ribosome binding
BR63_RS14845	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BR63_RS14855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BR63_RS14860	COG0049	tRNA binding
BR63_RS14865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BR63_RS14870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BR63_RS14875	COG0051	transcription antitermination factor activity, RNA binding
BR63_RS14880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BR63_RS14885	COG0088	Forms part of the polypeptide exit tunnel
BR63_RS14890	COG0089	rRNA binding
BR63_RS14895	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BR63_RS14900	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BR63_RS14905	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BR63_RS14910	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BR63_RS14915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BR63_RS14920	COG0255	Belongs to the universal ribosomal protein uL29 family
BR63_RS14930	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BR63_RS14935	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BR63_RS14945	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BR63_RS14950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BR63_RS14955	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BR63_RS14960	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BR63_RS14965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BR63_RS14970	COG1841	ribosomal large subunit assembly
BR63_RS14980	COG0201	protein transport
BR63_RS14985	COG0563	adenylate kinase activity
BR63_RS14995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BR63_RS15010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BR63_RS15015	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BR63_RS15020	COG0202	RNA polymerase activity
BR63_RS15030	COG1122	ATPase activity
BR63_RS15040	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BR63_RS15045	COG0101	tRNA pseudouridine synthase activity
BR63_RS15050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BR63_RS15055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BR63_RS15060	COG0860	N-Acetylmuramoyl-L-alanine amidase
BR63_RS15100	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BR63_RS15100	COG2199	diguanylate cyclase activity
BR63_RS15110	COG3885	ferrous iron binding
BR63_RS15110	COG2078	PFAM AMMECR1 domain protein
BR63_RS15115	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BR63_RS15120	COG0835	chemotaxis
BR63_RS15130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BR63_RS15135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BR63_RS15140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BR63_RS15145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BR63_RS15155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BR63_RS15170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BR63_RS15175	COG0137	argininosuccinate synthase activity
BR63_RS15180	COG0165	Argininosuccinate lyase
BR63_RS15185	COG0730	response to heat
BR63_RS15190	COG0730	response to heat
BR63_RS15195	COG0428	transporter
BR63_RS15215	COG0840	transmembrane signaling receptor activity
BR63_RS15235	COG2210	Belongs to the sulfur carrier protein TusA family
BR63_RS15240	COG4129	membrane
BR63_RS15250	COG0671	phosphoesterase, PA-phosphatase related
BR63_RS15260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BR63_RS15270	COG1404	Belongs to the peptidase S8 family
BR63_RS15280	COG3069	C4-dicarboxylate transmembrane transporter activity
BR63_RS15295	COG0183	Belongs to the thiolase family
BR63_RS15300	COG1250	3-hydroxyacyl-CoA dehydrogenase
BR63_RS15360	COG1773	rubredoxin
BR63_RS15375	COG0733	neurotransmitter:sodium symporter activity
BR63_RS15385	COG1301	dicarboxylic acid transport
BR63_RS15400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BR63_RS15415	COG1139	Iron-sulfur cluster binding protein
BR63_RS15420	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BR63_RS15425	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BR63_RS15465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BR63_RS15470	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BR63_RS15485	COG0697	spore germination
BR63_RS15500	COG5401	PFAM Sporulation and spore germination
BR63_RS15510	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BR63_RS15515	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BR63_RS15520	COG1234	tRNA 3'-trailer cleavage
BR63_RS15525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BR63_RS15530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BR63_RS15570	COG0544	peptidyl-prolyl cis-trans isomerase activity
BR63_RS15575	COG0740	serine-type endopeptidase activity
BR63_RS15580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BR63_RS15590	COG0470	DNA polymerase III
BR63_RS15590	COG1067	ATP-dependent peptidase activity
BR63_RS15595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BR63_RS15600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BR63_RS15610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BR63_RS15620	COG0525	valine-tRNA ligase activity
BR63_RS15625	COG0285	dihydrofolate synthase activity
BR63_RS15665	COG0517	IMP dehydrogenase activity
BR63_RS15665	COG0516	GMP reductase activity
BR63_RS15675	COG0587	DNA-directed DNA polymerase activity
BR63_RS15680	COG2205	protein histidine kinase activity
BR63_RS15690	COG0424	maF-like protein
BR63_RS15695	COG2003	Belongs to the UPF0758 family
BR63_RS15700	COG1077	Cell shape determining protein MreB Mrl
BR63_RS15705	COG1792	Involved in formation and maintenance of cell shape
BR63_RS15715	COG0768	penicillin binding
BR63_RS15720	COG0850	regulation of cytokinetic process
BR63_RS15725	COG2894	cell division
BR63_RS15735	COG0772	Belongs to the SEDS family
BR63_RS15760	COG5012	cobalamin binding
BR63_RS15765	COG1921	L-seryl-tRNASec selenium transferase activity
BR63_RS15795	COG3858	chitin binding
BR63_RS15825	COG1141	Ferredoxin
BR63_RS15835	COG2721	sulfolactate sulfo-lyase activity
BR63_RS15840	COG2721	sulfolactate sulfo-lyase activity
BR63_RS15845	COG3829	transcription factor binding
BR63_RS15845	COG3290	protein histidine kinase activity
BR63_RS15850	COG1827	regulation of RNA biosynthetic process
BR63_RS15855	COG4862	establishment of competence for transformation
BR63_RS15870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BR63_RS15880	COG1550	Protein conserved in bacteria
BR63_RS15890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BR63_RS15915	COG2423	ornithine cyclodeaminase activity
BR63_RS15950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BR63_RS15955	COG0066	3-isopropylmalate dehydratase activity
BR63_RS15965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BR63_RS15970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BR63_RS15980	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BR63_RS15980	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BR63_RS15985	COG0281	malic enzyme
BR63_RS15995	COG0066	3-isopropylmalate dehydratase activity
BR63_RS16000	COG2188	Transcriptional regulator
BR63_RS16005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BR63_RS16010	COG2423	ornithine cyclodeaminase activity
BR63_RS16055	COG2204	response regulator
BR63_RS16060	COG1960	acyl-CoA dehydrogenase activity
BR63_RS16065	COG2086	electron transfer activity
BR63_RS16070	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_RS16075	COG0644	oxidoreductase
BR63_RS16080	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BR63_RS16085	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BR63_RS16090	COG0287	Prephenate dehydrogenase
BR63_RS16095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BR63_RS16100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BR63_RS16105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BR63_RS16110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BR63_RS16145	COG4456	Virulence-associated protein
BR63_RS16150	COG1487	ribonuclease activity
BR63_RS16220	COG4109	DRTGG domain
BR63_RS16230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BR63_RS16235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BR63_RS16240	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BR63_RS16260	COG4496	protein, YerC YecD
BR63_RS16265	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BR63_RS16280	COG0131	Imidazoleglycerol-phosphate dehydratase
BR63_RS16290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BR63_RS16295	COG0107	imidazoleglycerol-phosphate synthase activity
BR63_RS16300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BR63_RS16300	COG0140	phosphoribosyl-ATP diphosphatase activity
BR63_RS16335	COG3275	phosphorelay sensor kinase activity
BR63_RS16340	COG3279	Response regulator of the LytR AlgR family
BR63_RS16350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BR63_RS16360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BR63_RS16375	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BR63_RS16380	COG0154	amidase activity
BR63_RS16385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BR63_RS16465	COG1361	Conserved repeat domain
BR63_RS16490	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BR63_RS16600	COG3177	Filamentation induced by cAMP protein fic
BR63_RS16740	COG1074	ATP-dependent DNA helicase activity
BR63_RS16815	COG0835	chemotaxis
BR63_RS16820	COG0840	transmembrane signaling receptor activity
BR63_RS16855	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BR63_RS16865	COG0732	type I restriction modification DNA specificity domain
BR63_RS16875	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BR63_RS16960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BR63_RS16965	COG0022	dehydrogenase e1 component
BR63_RS16970	COG0508	dehydrogenase complex catalyzes the overall conversion of
BR63_RS16975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BR63_RS16980	COG0321	lipoyl(octanoyl) transferase activity
BR63_RS16985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BR63_RS16995	COG2132	Multicopper oxidase
BR63_RS17045	COG1278	Cold shock
BR63_RS17070	COG0071	Belongs to the small heat shock protein (HSP20) family
BR63_RS17075	COG5002	protein histidine kinase activity
BR63_RS17205	COG3829	transcription factor binding
BR63_RS17245	COG1396	sequence-specific DNA binding
BR63_RS17255	COG0778	Nitroreductase
BR63_RS17260	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BR63_RS17265	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BR63_RS17265	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BR63_RS17270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_RS17275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS17280	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS17280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_RS17285	COG0277	FAD linked oxidase domain protein
BR63_RS17290	COG0277	FAD linked oxidase domain protein
BR63_RS17295	COG0247	lactate metabolic process
BR63_RS17300	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BR63_RS17305	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BR63_RS17310	COG3404	Formiminotransferase-cyclodeaminase
BR63_RS17315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BR63_RS17320	COG2116	formate transmembrane transporter activity
BR63_RS17340	COG0583	DNA-binding transcription factor activity
BR63_RS17355	COG2855	membrane
BR63_RS17360	COG0589	response to stress
BR63_RS17395	COG3706	GGDEF domain
BR63_RS17405	COG5001	Diguanylate cyclase
BR63_RS17405	COG3300	MHYT domain
BR63_RS17410	COG0583	DNA-binding transcription factor activity
BR63_RS17435	COG1366	Belongs to the anti-sigma-factor antagonist family
BR63_RS17455	COG0697	spore germination
BR63_RS17470	COG3290	protein histidine kinase activity
BR63_RS17475	COG4565	transcriptional regulatory protein
BR63_RS17485	COG0281	malic enzyme
BR63_RS17500	COG1053	succinate dehydrogenase
BR63_RS17510	COG2048	Heterodisulfide reductase, subunit B
BR63_RS17535	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BR63_RS17555	COG1131	(ABC) transporter
BR63_RS17575	COG0205	6-phosphofructokinase activity
BR63_RS17580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BR63_RS17580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BR63_RS17585	COG0513	Belongs to the DEAD box helicase family
BR63_RS17600	COG1773	rubredoxin
BR63_RS17600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BR63_RS17605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BR63_RS17610	COG0280	phosphate acetyltransferase
BR63_RS17620	COG2731	YhcH YjgK YiaL family protein
BR63_RS17625	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_RS17625	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_RS17625	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BR63_RS17625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BR63_RS17640	COG0546	phosphoglycolate phosphatase activity
BR63_RS17645	COG1615	UPF0182 protein
BR63_RS17680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_RS17685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS17690	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS17690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_RS17695	COG0129	dihydroxy-acid dehydratase activity
BR63_RS17700	COG0564	pseudouridine synthase activity
BR63_RS17715	COG0842	Transport permease protein
BR63_RS17720	COG0681	Belongs to the peptidase S26 family
BR63_RS17725	COG2186	Transcriptional regulator
BR63_RS17730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BR63_RS17745	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BR63_RS17750	COG4770	biotin carboxylase activity
BR63_RS17760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BR63_RS17765	COG1960	acyl-CoA dehydrogenase activity
BR63_RS17770	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BR63_RS17780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BR63_RS17785	COG1250	3-hydroxyacyl-CoA dehydrogenase
BR63_RS17790	COG1024	Enoyl-CoA hydratase
BR63_RS17795	COG0006	proline dipeptidase activity
BR63_RS17800	COG0840	transmembrane signaling receptor activity
BR63_RS17805	COG2086	electron transfer activity
BR63_RS17810	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_RS17815	COG3290	protein histidine kinase activity
BR63_RS17815	COG3829	transcription factor binding
BR63_RS17820	COG0427	acetyl-CoA hydrolase
BR63_RS17825	COG0659	secondary active sulfate transmembrane transporter activity
BR63_RS17835	COG2414	aldehyde ferredoxin oxidoreductase
BR63_RS17840	COG3290	protein histidine kinase activity
BR63_RS17840	COG3829	transcription factor binding
BR63_RS17845	COG3829	transcription factor binding
BR63_RS17845	COG3290	protein histidine kinase activity
BR63_RS17855	COG0420	3'-5' exonuclease activity
BR63_RS17860	COG0419	ATPase involved in DNA repair
BR63_RS17865	COG1671	Belongs to the UPF0178 family
BR63_RS17875	COG2814	Major facilitator Superfamily
BR63_RS17880	COG5002	protein histidine kinase activity
BR63_RS17885	COG0745	RESPONSE REGULATOR receiver
BR63_RS17890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BR63_RS17895	COG1136	(ABC) transporter
BR63_RS17900	COG0577	efflux transmembrane transporter activity
BR63_RS17900	COG1136	(ABC) transporter
BR63_RS17910	COG1414	Transcriptional regulator
BR63_RS17930	COG1960	acyl-CoA dehydrogenase activity
BR63_RS17935	COG2086	electron transfer activity
BR63_RS17940	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BR63_RS17945	COG0644	oxidoreductase
BR63_RS17950	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BR63_RS17960	COG0154	amidase activity
BR63_RS17985	COG1473	amidohydrolase
BR63_RS17995	COG1793	dna ligase
BR63_RS18000	COG1793	dna ligase
BR63_RS18000	COG3285	dna ligase
BR63_RS18005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BR63_RS18015	COG1196	nuclear chromosome segregation
BR63_RS18015	COG0741	lytic transglycosylase activity
BR63_RS18015	COG0739	heme binding
BR63_RS18030	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BR63_RS18045	COG1696	Membrane protein involved in D-alanine export
BR63_RS18055	COG0789	Transcriptional regulator
BR63_RS18060	COG0501	Belongs to the peptidase M48B family
BR63_RS18065	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BR63_RS18075	COG1649	PFAM Uncharacterised BCR, COG1649
BR63_RS18075	COG0726	polysaccharide deacetylase
BR63_RS18085	COG2972	Histidine kinase
BR63_RS18090	COG2201	protein-glutamate methylesterase activity
BR63_RS18150	COG4869	propanediol catabolic process
BR63_RS18160	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
BR63_RS18165	COG2096	Adenosyltransferase
BR63_RS18170	COG1012	belongs to the aldehyde dehydrogenase family
BR63_RS18175	COG4656	Part of a membrane complex involved in electron transport
BR63_RS18185	COG0640	Transcriptional regulator
BR63_RS18190	COG4166	transmembrane transport
BR63_RS18195	COG4608	Belongs to the ABC transporter superfamily
BR63_RS18200	COG0444	Belongs to the ABC transporter superfamily
BR63_RS18205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BR63_RS18210	COG0601	transmembrane transport
BR63_RS18220	COG3383	formate dehydrogenase (NAD+) activity
BR63_RS18225	COG1361	Conserved repeat domain
BR63_RS18230	COG1408	metallophosphoesterase
BR63_RS18235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BR63_RS18240	COG1116	anion transmembrane transporter activity
BR63_RS18250	COG0534	Mate efflux family protein
BR63_RS18255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BR63_RS18260	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BR63_RS18260	COG0517	IMP dehydrogenase activity
BR63_RS18270	COG1802	Transcriptional regulator
BR63_RS18275	COG4232	protein-disulfide reductase activity
BR63_RS18285	COG1802	Transcriptional regulator
BR63_RS18290	COG0473	3-isopropylmalate dehydrogenase activity
BR63_RS18295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BR63_RS18300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BR63_RS18310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BR63_RS18320	COG1027	Aspartate ammonia-lyase
BR63_RS18325	COG1160	GTP binding
BR63_RS18330	COG0436	Aminotransferase
BR63_RS18335	COG4191	Histidine kinase
BR63_RS18340	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BR63_RS18350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BR63_RS18370	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
BR63_RS18380	COG0444	Belongs to the ABC transporter superfamily
BR63_RS18385	COG0747	negative chemotaxis
BR63_RS18395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BR63_RS18400	COG4608	Belongs to the ABC transporter superfamily
BR63_RS18410	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BR63_RS18415	COG2186	Transcriptional regulator
BR63_RS18445	COG0179	Fumarylacetoacetate (FAA) hydrolase
BR63_RS18450	COG1028	Short-chain dehydrogenase reductase Sdr
BR63_RS18455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BR63_RS18460	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BR63_RS18470	COG3835	regulator
BR63_RS18480	COG1013	pyruvate-flavodoxin oxidoreductase activity
BR63_RS18485	COG0674	pyruvate-flavodoxin oxidoreductase activity
BR63_RS18485	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BR63_RS18495	COG3279	Response regulator of the LytR AlgR family
BR63_RS18510	COG0129	dihydroxy-acid dehydratase activity
BR63_RS18515	COG1929	Belongs to the glycerate kinase type-1 family
BR63_RS18530	COG3706	GGDEF domain
BR63_RS18540	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BR63_RS18565	COG2195	Cleaves the N-terminal amino acid of tripeptides
BR63_RS18575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BR63_RS18580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BR63_RS18620	COG0840	transmembrane signaling receptor activity
BR63_RS18650	COG1546	Belongs to the CinA family
BR63_RS18650	COG1058	Belongs to the CinA family
BR63_RS18660	COG4569	acetaldehyde dehydrogenase (acetylating) activity
BR63_RS18665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BR63_RS18675	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BR63_RS18690	COG1522	sequence-specific DNA binding
BR63_RS18695	COG1522	sequence-specific DNA binding
BR63_RS18700	COG0535	radical SAM domain protein
BR63_RS18725	COG1691	(AIR) carboxylase
BR63_RS18730	COG1606	tRNA processing
BR63_RS18740	COG0697	spore germination
BR63_RS18770	COG1122	ATPase activity
BR63_RS18785	COG0598	Magnesium transport protein CorA
BR63_RS18810	COG2200	EAL domain
BR63_RS18815	COG1136	(ABC) transporter
BR63_RS18825	COG1136	(ABC) transporter
BR63_RS18825	COG0577	efflux transmembrane transporter activity
BR63_RS18830	COG0371	Dehydrogenase
BR63_RS18835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BR63_RS18840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BR63_RS18845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BR63_RS18860	COG2022	thiamine diphosphate biosynthetic process
BR63_RS18860	COG2104	thiamine diphosphate biosynthetic process
BR63_RS18865	COG2022	thiamine diphosphate biosynthetic process
BR63_RS18875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BR63_RS18880	COG0351	phosphomethylpyrimidine kinase
BR63_RS18890	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BR63_RS18905	COG2070	2-Nitropropane dioxygenase
BR63_RS18910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BR63_RS18915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BR63_RS18920	COG3290	protein histidine kinase activity
BR63_RS18920	COG3829	transcription factor binding
BR63_RS18930	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BR63_RS18935	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS18940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BR63_RS18940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BR63_RS18945	COG3069	C4-dicarboxylate transmembrane transporter activity
BR63_RS18950	COG0733	neurotransmitter:sodium symporter activity
BR63_RS18975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BR63_RS18980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BR63_RS18985	COG3437	response regulator, receiver
BR63_RS18995	COG0516	GMP reductase activity
BR63_RS18995	COG0517	IMP dehydrogenase activity
BR63_RS19000	COG5002	protein histidine kinase activity
BR63_RS19005	COG0745	RESPONSE REGULATOR receiver
BR63_RS19020	COG0798	PFAM Bile acid sodium symporter
BR63_RS19030	COG0310	cobalt ion transport
BR63_RS19040	COG1122	ATPase activity
BR63_RS19045	COG0671	phosphoesterase, PA-phosphatase related
BR63_RS19060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BR63_RS19110	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BR63_RS19110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BR63_RS19140	COG4974	Belongs to the 'phage' integrase family
BR63_RS19200	COG4695	Portal protein
BR63_RS19285	COG3299	homolog of phage Mu protein gp47