locus-tag	class	description
THECO_RS00010	COG2195	Cleaves the N-terminal amino acid of tripeptides
THECO_RS00015	COG0069	glutamate synthase activity
THECO_RS00020	COG2094	Belongs to the DNA glycosylase MPG family
THECO_RS00025	COG1063	alcohol dehydrogenase
THECO_RS00030	COG0659	secondary active sulfate transmembrane transporter activity
THECO_RS00040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THECO_RS00050	COG2207	Transcriptional regulator
THECO_RS00050	COG3708	Transcriptional regulator
THECO_RS00055	COG3693	PFAM glycoside hydrolase, family 10
THECO_RS00070	COG0477	Major facilitator Superfamily
THECO_RS00075	COG1846	Transcriptional regulator
THECO_RS00085	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THECO_RS00090	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THECO_RS00095	COG3507	Belongs to the glycosyl hydrolase 43 family
THECO_RS00110	COG2972	Histidine kinase
THECO_RS00115	COG2207	Transcriptional regulator
THECO_RS00115	COG4753	response regulator
THECO_RS00120	COG1653	transport
THECO_RS00130	COG4989	oxidoreductase activity
THECO_RS00145	COG0500	methyltransferase
THECO_RS00150	COG1028	Short-chain dehydrogenase reductase Sdr
THECO_RS00160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THECO_RS00165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THECO_RS00170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THECO_RS00175	COG1131	(ABC) transporter
THECO_RS00200	COG4166	transmembrane transport
THECO_RS00205	COG0601	transmembrane transport
THECO_RS00210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THECO_RS00215	COG0444	Belongs to the ABC transporter superfamily
THECO_RS00220	COG4608	Belongs to the ABC transporter superfamily
THECO_RS00225	COG3942	CHAP domain
THECO_RS00225	COG1388	LysM domain
THECO_RS00230	COG1442	glycosyl transferase family 8
THECO_RS00240	COG2755	lipolytic protein G-D-S-L family
THECO_RS00240	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
THECO_RS00245	COG0579	oxidoreductase
THECO_RS00250	COG0861	Integral membrane protein TerC family
THECO_RS00260	COG1335	isochorismatase
THECO_RS00265	COG0346	lactoylglutathione lyase activity
THECO_RS00275	COG4753	response regulator
THECO_RS00275	COG2207	Transcriptional regulator
THECO_RS00280	COG2972	Histidine kinase
THECO_RS00285	COG1879	ABC-type sugar transport system periplasmic component
THECO_RS00295	COG1172	Belongs to the binding-protein-dependent transport system permease family
THECO_RS00300	COG1172	Belongs to the binding-protein-dependent transport system permease family
THECO_RS00305	COG1879	ABC-type sugar transport system periplasmic component
THECO_RS00310	COG2801	Transposase and inactivated derivatives
THECO_RS00345	COG2363	Small membrane protein
THECO_RS00350	COG4974	Belongs to the 'phage' integrase family
THECO_RS00355	COG4974	Belongs to the 'phage' integrase family
THECO_RS00385	COG2217	Heavy metal translocating P-type atpase
THECO_RS00395	COG1914	H( )-stimulated, divalent metal cation uptake system
THECO_RS00430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THECO_RS00440	COG1309	transcriptional regulator
THECO_RS00465	COG1285	pathogenesis
THECO_RS00475	COG1178	ABC-type Fe3 transport system permease component
THECO_RS00480	COG3842	ATPase activity
THECO_RS00485	COG1840	ABC-type Fe3 transport system, periplasmic component
THECO_RS00490	COG2188	Transcriptional regulator
THECO_RS00520	COG3620	sequence-specific DNA binding
THECO_RS00530	COG0242	peptide deformylase activity
THECO_RS00545	COG1673	EVE domain
THECO_RS00555	COG2378	regulation of single-species biofilm formation
THECO_RS00570	COG1902	pentaerythritol trinitrate reductase activity
THECO_RS00575	COG0733	neurotransmitter:sodium symporter activity
THECO_RS00590	COG2814	Major facilitator Superfamily
THECO_RS00595	COG0640	Transcriptional regulator
THECO_RS00610	COG3344	reverse transcriptase
THECO_RS00620	COG2337	Toxic component of a toxin-antitoxin (TA) module
THECO_RS00625	COG2336	PFAM SpoVT AbrB
THECO_RS00630	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THECO_RS00640	COG0656	L-ascorbic acid biosynthetic process
THECO_RS00645	COG3344	reverse transcriptase
THECO_RS00655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THECO_RS00665	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
THECO_RS00680	COG5002	protein histidine kinase activity
THECO_RS00685	COG0745	RESPONSE REGULATOR receiver
THECO_RS00690	COG0739	heme binding
THECO_RS00720	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
THECO_RS00740	COG3418	PFAM FlgN family protein
THECO_RS00745	COG1256	bacterial-type flagellum assembly
THECO_RS00745	COG4786	Flagellar basal body rod
THECO_RS00750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THECO_RS00765	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THECO_RS00770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THECO_RS00780	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THECO_RS00805	COG1086	Polysaccharide biosynthesis protein
THECO_RS00810	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
THECO_RS00825	COG2089	acid synthase
THECO_RS00835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THECO_RS00840	COG1278	Cold shock
THECO_RS00850	COG0653	protein targeting
THECO_RS00855	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THECO_RS00875	COG1131	(ABC) transporter
THECO_RS00880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THECO_RS00885	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THECO_RS00890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THECO_RS00900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THECO_RS00905	COG0137	argininosuccinate synthase activity
THECO_RS00910	COG0165	Argininosuccinate lyase
THECO_RS00915	COG2884	Cell division ATP-binding protein ftsE
THECO_RS00920	COG2177	Part of the ABC transporter FtsEX involved in
THECO_RS00925	COG0739	heme binding
THECO_RS00930	COG3409	Peptidoglycan-binding domain 1 protein
THECO_RS00930	COG0793	Belongs to the peptidase S41A family
THECO_RS00935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THECO_RS00950	COG0556	nucleotide-excision repair
THECO_RS00970	COG1191	sigma factor activity
THECO_RS00980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THECO_RS01015	COG0826	peptidase U32
THECO_RS01025	COG2208	phosphoserine phosphatase activity
THECO_RS01025	COG2770	Histidine kinase
THECO_RS01035	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
THECO_RS01040	COG0210	DNA helicase
THECO_RS01045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THECO_RS01075	COG3880	PFAM UvrB UvrC protein
THECO_RS01080	COG3869	Catalyzes the specific phosphorylation of arginine residues in
THECO_RS01085	COG0542	response to heat
THECO_RS01115	COG1132	(ABC) transporter
THECO_RS01125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THECO_RS01130	COG0463	Glycosyl transferase, family 2
THECO_RS01130	COG1216	Glycosyl transferase, family 2
THECO_RS01135	COG4260	virion core protein, lumpy skin disease virus
THECO_RS01140	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
THECO_RS01145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THECO_RS01150	COG1842	Phage shock protein A
THECO_RS01155	COG1073	alpha beta
THECO_RS01160	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THECO_RS01165	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
THECO_RS01170	COG1183	phosphatidylcholine synthase activity
THECO_RS01180	COG4956	integral membrane protein (PIN domain superfamily)
THECO_RS01190	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THECO_RS01190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THECO_RS01195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THECO_RS01200	COG1045	serine acetyltransferase
THECO_RS01205	COG0215	cysteine-tRNA ligase activity
THECO_RS01210	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
THECO_RS01215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THECO_RS01220	COG3688	RNA-binding protein containing a PIN domain
THECO_RS01225	COG1131	(ABC) transporter
THECO_RS01235	COG1309	transcriptional regulator
THECO_RS01260	COG2801	Transposase and inactivated derivatives
THECO_RS01265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THECO_RS01275	COG0250	Participates in transcription elongation, termination and antitermination
THECO_RS01280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THECO_RS01285	COG0081	regulation of translation
THECO_RS01290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THECO_RS01295	COG0222	ribosome binding
THECO_RS01300	COG2813	Specifically methylates the guanine in position
THECO_RS01305	COG0085	RNA polymerase activity
THECO_RS01310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THECO_RS01315	COG1358	cellular component organization or biogenesis
THECO_RS01320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THECO_RS01325	COG0049	tRNA binding
THECO_RS01330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THECO_RS01335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THECO_RS01340	COG1120	ATPase activity
THECO_RS01345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THECO_RS01355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THECO_RS01360	COG0088	Forms part of the polypeptide exit tunnel
THECO_RS01365	COG0089	rRNA binding
THECO_RS01370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THECO_RS01375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THECO_RS01380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THECO_RS01385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THECO_RS01390	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THECO_RS01395	COG0255	Belongs to the universal ribosomal protein uL29 family
THECO_RS01405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THECO_RS01410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THECO_RS01415	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THECO_RS01420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THECO_RS01425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THECO_RS01430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THECO_RS01435	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THECO_RS01440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THECO_RS01445	COG1841	ribosomal large subunit assembly
THECO_RS01450	COG0200	Binds to the 23S rRNA
THECO_RS01455	COG0201	protein transport
THECO_RS01460	COG0563	adenylate kinase activity
THECO_RS01465	COG0024	Methionine aminopeptidase
THECO_RS01475	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THECO_RS01480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THECO_RS01485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THECO_RS01490	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THECO_RS01495	COG0202	RNA polymerase activity
THECO_RS01500	COG0203	ribosomal protein L17
THECO_RS01505	COG0101	tRNA pseudouridine synthase activity
THECO_RS01510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THECO_RS01515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THECO_RS01520	COG0175	sulfate reduction
THECO_RS01530	COG0860	N-Acetylmuramoyl-L-alanine amidase
THECO_RS01535	COG0489	protein tyrosine kinase activity
THECO_RS01550	COG0726	polysaccharide deacetylase
THECO_RS01650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THECO_RS01655	COG1595	DNA-templated transcription, initiation
THECO_RS01660	COG5662	AntiSigma factor
THECO_RS01665	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
THECO_RS01670	COG4856	YbbR-like protein
THECO_RS01675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THECO_RS01680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THECO_RS01690	COG4372	Transposase
THECO_RS01695	COG3547	Transposase (IS116 IS110 IS902 family)
THECO_RS01715	COG0346	lactoylglutathione lyase activity
THECO_RS01720	COG2197	response regulator
THECO_RS01725	COG4585	Histidine kinase
THECO_RS01730	COG2311	Membrane
THECO_RS01755	COG0583	DNA-binding transcription factor activity
THECO_RS01760	COG0456	acetyltransferase
THECO_RS01775	COG1252	NADH dehydrogenase
THECO_RS01815	COG2972	Histidine kinase
THECO_RS01820	COG2207	Transcriptional regulator
THECO_RS01825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THECO_RS01845	COG3655	Transcriptional regulator
THECO_RS01850	COG3739	integral membrane protein
THECO_RS01875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THECO_RS01885	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THECO_RS01890	COG0583	DNA-binding transcription factor activity
THECO_RS01925	COG0492	ferredoxin-NADP+ reductase activity
THECO_RS01940	COG0431	NADPH-dependent FMN reductase
THECO_RS01945	COG0640	Transcriptional regulator
THECO_RS01950	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
THECO_RS01955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
THECO_RS01965	COG3275	phosphorelay sensor kinase activity
THECO_RS01970	COG2204	response regulator
THECO_RS01975	COG1653	transport
THECO_RS01980	COG4209	transmembrane transport
THECO_RS01985	COG0395	ABC-type sugar transport system, permease component
THECO_RS01990	COG1472	Belongs to the glycosyl hydrolase 3 family
THECO_RS01995	COG0583	DNA-binding transcription factor activity
THECO_RS02000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
THECO_RS02005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THECO_RS02020	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
THECO_RS02040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THECO_RS02045	COG4172	Belongs to the ABC transporter superfamily
THECO_RS02070	COG1486	melibiose metabolic process
THECO_RS02080	COG0129	dihydroxy-acid dehydratase activity
THECO_RS02095	COG1414	Transcriptional regulator
THECO_RS02120	COG2972	Histidine kinase
THECO_RS02125	COG4753	response regulator
THECO_RS02125	COG2207	Transcriptional regulator
THECO_RS02140	COG0601	transmembrane transport
THECO_RS02150	COG0444	Belongs to the ABC transporter superfamily
THECO_RS02155	COG4608	Belongs to the ABC transporter superfamily
THECO_RS02160	COG1472	Belongs to the glycosyl hydrolase 3 family
THECO_RS02165	COG1131	(ABC) transporter
THECO_RS02180	COG0745	RESPONSE REGULATOR receiver
THECO_RS02185	COG5002	protein histidine kinase activity
THECO_RS02190	COG3001	Fructosamine kinase
THECO_RS02220	COG1472	Belongs to the glycosyl hydrolase 3 family
THECO_RS02225	COG2972	Histidine kinase
THECO_RS02230	COG2207	Transcriptional regulator
THECO_RS02230	COG4753	response regulator
THECO_RS02240	COG1175	transmembrane transport
THECO_RS02250	COG1874	Beta-galactosidase
THECO_RS02270	COG0662	Cupin 2, conserved barrel domain protein
THECO_RS02280	COG1489	DNA binding
THECO_RS02285	COG0842	Transport permease protein
THECO_RS02295	COG1131	(ABC) transporter
THECO_RS02305	COG2197	response regulator
THECO_RS02320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
THECO_RS02355	COG0656	L-ascorbic acid biosynthetic process
THECO_RS02365	COG2972	Histidine kinase
THECO_RS02370	COG2207	Transcriptional regulator
THECO_RS02375	COG1653	transport
THECO_RS02390	COG3344	reverse transcriptase
THECO_RS02400	COG0791	NLP P60 protein
THECO_RS02415	COG1486	melibiose metabolic process
THECO_RS02435	COG4124	Belongs to the glycosyl hydrolase 26 family
THECO_RS02450	COG0740	serine-type endopeptidase activity
THECO_RS02470	COG1028	Short-chain dehydrogenase reductase Sdr
THECO_RS02480	COG3153	acetyltransferase
THECO_RS02480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THECO_RS02490	COG0673	inositol 2-dehydrogenase activity
THECO_RS02505	COG0800	Aldolase
THECO_RS02510	COG1028	Short-chain dehydrogenase reductase Sdr
THECO_RS02520	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
THECO_RS02530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
THECO_RS02540	COG0488	(ABC) transporter
THECO_RS02550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
THECO_RS02560	COG3344	reverse transcriptase
THECO_RS02570	COG0395	ABC-type sugar transport system, permease component
THECO_RS02575	COG1175	transmembrane transport
THECO_RS02580	COG1653	transport
THECO_RS02590	COG4129	membrane
THECO_RS02605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THECO_RS02615	COG1175	transmembrane transport
THECO_RS02620	COG0395	ABC-type sugar transport system, permease component
THECO_RS02625	COG1653	transport
THECO_RS02630	COG1312	Catalyzes the dehydration of D-mannonate
THECO_RS02660	COG3336	cytochrome c oxidase
THECO_RS02680	COG4152	abc transporter atp-binding protein
THECO_RS02685	COG1668	transmembrane transport
THECO_RS02700	COG1609	Transcriptional regulator
THECO_RS02710	COG3458	cephalosporin-C deacetylase activity
THECO_RS02715	COG2223	nitrite transmembrane transporter activity
THECO_RS02720	COG0488	(ABC) transporter
THECO_RS02735	COG0315	cyclic pyranopterin monophosphate synthase activity
THECO_RS02740	COG0521	Mo-molybdopterin cofactor biosynthetic process
THECO_RS02750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THECO_RS02755	COG0805	protein transport
THECO_RS02760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THECO_RS02765	COG0459	protein refolding
THECO_RS02770	COG0736	holo-[acyl-carrier-protein] synthase activity
THECO_RS02790	COG3314	Sporulation integral membrane protein YlbJ
THECO_RS02795	COG2346	COG2346, Truncated hemoglobins
THECO_RS02840	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
THECO_RS02845	COG1494	fructose-1,6-bisphosphatase
THECO_RS02850	COG0105	UTP biosynthetic process
THECO_RS02870	COG1653	transport
THECO_RS02875	COG1175	transmembrane transport
THECO_RS02880	COG0395	ABC-type sugar transport system, permease component
THECO_RS02960	COG1090	epimerase
THECO_RS02970	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THECO_RS02975	COG0788	formyltetrahydrofolate deformylase activity
THECO_RS02995	COG1739	Uncharacterized protein family UPF0029
THECO_RS03005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THECO_RS03015	COG0561	phosphatase activity
THECO_RS03020	COG0793	Belongs to the peptidase S41A family
THECO_RS03020	COG3409	Peptidoglycan-binding domain 1 protein
THECO_RS03030	COG0024	Methionine aminopeptidase
THECO_RS03040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THECO_RS03045	COG4565	transcriptional regulatory protein
THECO_RS03050	COG3275	phosphorelay sensor kinase activity
THECO_RS03055	COG1653	transport
THECO_RS03070	COG0246	Mannitol dehydrogenase
THECO_RS03075	COG2721	sulfolactate sulfo-lyase activity
THECO_RS03090	COG0668	transmembrane transport
THECO_RS03095	COG3275	phosphorelay sensor kinase activity
THECO_RS03100	COG2207	Transcriptional regulator
THECO_RS03105	COG4209	transmembrane transport
THECO_RS03110	COG0395	ABC-type sugar transport system, permease component
THECO_RS03115	COG1653	transport
THECO_RS03135	COG1842	Phage shock protein A
THECO_RS03145	COG1842	Phage shock protein A
THECO_RS03150	COG4585	Histidine kinase
THECO_RS03155	COG2197	response regulator
THECO_RS03160	COG1763	Mo-molybdopterin cofactor biosynthetic process
THECO_RS03180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THECO_RS03195	COG2204	response regulator
THECO_RS03200	COG1175	transmembrane transport
THECO_RS03205	COG0395	ABC-type sugar transport system, permease component
THECO_RS03225	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
THECO_RS03230	COG2706	6-phosphogluconolactonase activity
THECO_RS03235	COG1073	alpha beta
THECO_RS03240	COG1470	cell adhesion involved in biofilm formation
THECO_RS03245	COG1392	Phosphate transport regulator
THECO_RS03250	COG0306	phosphate transporter
THECO_RS03260	COG4496	protein, YerC YecD
THECO_RS03270	COG1597	lipid kinase activity
THECO_RS03275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THECO_RS03280	COG0745	RESPONSE REGULATOR receiver
THECO_RS03285	COG5002	protein histidine kinase activity
THECO_RS03285	COG3850	Histidine kinase
THECO_RS03310	COG2801	Transposase and inactivated derivatives
THECO_RS03315	COG4948	Mandelate Racemase Muconate Lactonizing
THECO_RS03350	COG1660	Displays ATPase and GTPase activities
THECO_RS03360	COG2153	protein acetylation
THECO_RS03370	COG3266	domain, Protein
THECO_RS03370	COG2911	Protein conserved in bacteria
THECO_RS03370	COG1361	Conserved repeat domain
THECO_RS03375	COG1686	Belongs to the peptidase S11 family
THECO_RS03385	COG1695	Transcriptional regulator
THECO_RS03395	COG1309	transcriptional regulator
THECO_RS03460	COG2201	protein-glutamate methylesterase activity
THECO_RS03465	COG0784	Response regulator, receiver
THECO_RS03465	COG3437	response regulator, receiver
THECO_RS03470	COG0840	transmembrane signaling receptor activity
THECO_RS03485	COG1215	transferase activity, transferring glycosyl groups
THECO_RS03510	COG2318	DinB family
THECO_RS03515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THECO_RS03525	COG4149	molybdate abc transporter
THECO_RS03535	COG0746	molybdenum cofactor guanylyltransferase activity
THECO_RS03545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THECO_RS03575	COG1653	transport
THECO_RS03675	COG1380	Effector of murein hydrolase LrgA
THECO_RS03680	COG1346	cytolysis
THECO_RS03685	COG1902	pentaerythritol trinitrate reductase activity
THECO_RS03710	COG1309	transcriptional regulator
THECO_RS03740	COG1653	transport
THECO_RS03755	COG0395	ABC-type sugar transport system, permease component
THECO_RS03795	COG1136	(ABC) transporter
THECO_RS03800	COG1136	(ABC) transporter
THECO_RS03800	COG0577	efflux transmembrane transporter activity
THECO_RS03810	COG1752	Esterase of the alpha-beta hydrolase superfamily
THECO_RS03845	COG1309	transcriptional regulator
THECO_RS03855	COG2011	ABC-type metal ion transport system permease component
THECO_RS03860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
THECO_RS03865	COG0667	Aldo Keto reductase
THECO_RS03875	COG0745	RESPONSE REGULATOR receiver
THECO_RS03880	COG5002	protein histidine kinase activity
THECO_RS03905	COG0494	nUDIX hydrolase
THECO_RS03915	COG1121	(ABC) transporter
THECO_RS03935	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THECO_RS03935	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THECO_RS03945	COG0326	Molecular chaperone. Has ATPase activity
THECO_RS03960	COG0860	N-Acetylmuramoyl-L-alanine amidase
THECO_RS03975	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
THECO_RS03995	COG0667	Aldo Keto reductase
THECO_RS04000	COG3584	3D domain protein
THECO_RS04000	COG1388	LysM domain
THECO_RS04005	COG0726	polysaccharide deacetylase
THECO_RS04030	COG0180	Tryptophanyl-tRNA synthetase
THECO_RS04050	COG3773	Cell wall hydrolase
THECO_RS04060	COG1999	signal sequence binding
THECO_RS04085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THECO_RS04120	COG2972	Histidine kinase
THECO_RS04125	COG4753	response regulator
THECO_RS04125	COG2207	Transcriptional regulator
THECO_RS04130	COG4213	ABC transporter substrate-binding protein
THECO_RS04140	COG4214	carbohydrate transport
THECO_RS04145	COG0561	phosphatase activity
THECO_RS04160	COG2244	polysaccharide biosynthetic process
THECO_RS04180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THECO_RS04185	COG1612	heme a metabolic process
THECO_RS04195	COG1028	Short-chain dehydrogenase reductase Sdr
THECO_RS04200	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
THECO_RS04205	COG4844	belongs to the
THECO_RS04210	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THECO_RS04215	COG0316	Belongs to the HesB IscA family
THECO_RS04230	COG0840	transmembrane signaling receptor activity
THECO_RS04240	COG3275	phosphorelay sensor kinase activity
THECO_RS04250	COG4213	ABC transporter substrate-binding protein
THECO_RS04265	COG4214	carbohydrate transport
THECO_RS04320	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
THECO_RS04325	COG4988	ABC transporter
THECO_RS04330	COG1294	oxidase, subunit
THECO_RS04335	COG1271	oxidase subunit
THECO_RS04340	COG0745	RESPONSE REGULATOR receiver
THECO_RS04345	COG5002	protein histidine kinase activity
THECO_RS04345	COG3850	Histidine kinase
THECO_RS04350	COG1136	(ABC) transporter
THECO_RS04390	COG0456	acetyltransferase
THECO_RS04425	COG1214	PFAM Peptidase M22, glycoprotease
THECO_RS04425	COG0456	acetyltransferase
THECO_RS04435	COG1349	DNA-binding transcription factor activity
THECO_RS04455	COG0477	Major facilitator Superfamily
THECO_RS04460	COG1609	Transcriptional regulator
THECO_RS04465	COG4209	transmembrane transport
THECO_RS04470	COG0395	ABC-type sugar transport system, permease component
THECO_RS04480	COG3250	beta-galactosidase activity
THECO_RS04500	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
THECO_RS04500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
THECO_RS04520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THECO_RS04550	COG3459	Glycosyltransferase 36 associated
THECO_RS04565	COG1902	pentaerythritol trinitrate reductase activity
THECO_RS04570	COG1272	protein, Hemolysin III
THECO_RS04575	COG1028	Short-chain dehydrogenase reductase Sdr
THECO_RS04580	COG3620	sequence-specific DNA binding
THECO_RS04605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THECO_RS04615	COG1191	sigma factor activity
THECO_RS04620	COG4753	response regulator
THECO_RS04620	COG2207	Transcriptional regulator
THECO_RS04625	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THECO_RS04630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THECO_RS04635	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
THECO_RS04665	COG3706	GGDEF domain
THECO_RS04695	COG0586	Pfam SNARE associated Golgi protein
THECO_RS04705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THECO_RS04725	COG2183	response to ionizing radiation
THECO_RS04730	COG0778	Nitroreductase
THECO_RS04740	COG3091	SprT-like family
THECO_RS04780	COG1069	ribulokinase activity
THECO_RS04800	COG1609	Transcriptional regulator
THECO_RS04805	COG2972	Histidine kinase
THECO_RS04810	COG2207	Transcriptional regulator
THECO_RS04810	COG4753	response regulator
THECO_RS04815	COG2182	Extracellular solute-binding protein
THECO_RS04820	COG1175	transmembrane transport
THECO_RS04840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THECO_RS04840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THECO_RS04845	COG1482	cell wall glycoprotein biosynthetic process
THECO_RS04850	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
THECO_RS04855	COG1242	4 iron, 4 sulfur cluster binding
THECO_RS04860	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THECO_RS04865	COG0671	phosphoesterase, PA-phosphatase related
THECO_RS04870	COG1215	transferase activity, transferring glycosyl groups
THECO_RS04885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THECO_RS04890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THECO_RS04900	COG0028	Belongs to the TPP enzyme family
THECO_RS04905	COG0440	acetolactate synthase activity
THECO_RS04910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THECO_RS04915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THECO_RS04920	COG0473	3-isopropylmalate dehydrogenase activity
THECO_RS04935	COG1191	sigma factor activity
THECO_RS04945	COG4191	Histidine kinase
THECO_RS04950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THECO_RS04960	COG1132	(ABC) transporter
THECO_RS04985	COG1733	regulation of RNA biosynthetic process
THECO_RS04995	COG1472	Belongs to the glycosyl hydrolase 3 family
THECO_RS05010	COG0386	Belongs to the glutathione peroxidase family
THECO_RS05015	COG0322	excinuclease ABC activity
THECO_RS05040	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
THECO_RS05050	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
THECO_RS05055	COG3300	MHYT domain
THECO_RS05055	COG5001	Diguanylate cyclase
THECO_RS05065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THECO_RS05070	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
THECO_RS05080	COG0789	Transcriptional regulator
THECO_RS05095	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
THECO_RS05110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THECO_RS05115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THECO_RS05120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THECO_RS05165	COG1175	transmembrane transport
THECO_RS05175	COG3507	Belongs to the glycosyl hydrolase 43 family
THECO_RS05180	COG3250	beta-galactosidase activity
THECO_RS05200	COG1131	(ABC) transporter
THECO_RS05225	COG1132	(ABC) transporter
THECO_RS05230	COG1132	(ABC) transporter
THECO_RS05245	COG0745	RESPONSE REGULATOR receiver
THECO_RS05255	COG1312	Catalyzes the dehydration of D-mannonate
THECO_RS05260	COG1028	Short-chain dehydrogenase reductase Sdr
THECO_RS05280	COG5566	PFAM Mor transcription activator
THECO_RS05290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THECO_RS05305	COG3850	Histidine kinase
THECO_RS05310	COG2197	response regulator
THECO_RS05325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THECO_RS05330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THECO_RS05330	COG0072	phenylalanine-tRNA ligase activity
THECO_RS05335	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
THECO_RS05350	COG1193	negative regulation of DNA recombination
THECO_RS05355	COG3766	membrane
THECO_RS05365	COG0477	Major facilitator Superfamily
THECO_RS05370	COG5337	Spore coat protein CotH
THECO_RS05390	COG1522	sequence-specific DNA binding
THECO_RS05395	COG0436	Aminotransferase
THECO_RS05405	COG2096	Adenosyltransferase
THECO_RS05415	COG1393	Belongs to the ArsC family
THECO_RS05440	COG0300	oxidoreductase activity
THECO_RS05455	COG1131	(ABC) transporter
THECO_RS05460	COG4473	ABC transporter
THECO_RS05465	COG2309	aminopeptidase activity
THECO_RS05475	COG2207	Transcriptional regulator
THECO_RS05490	COG0688	phosphatidylethanolamine metabolic process
THECO_RS05495	COG0438	transferase activity, transferring glycosyl groups
THECO_RS05500	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THECO_RS05505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THECO_RS05510	COG0352	thiamine-phosphate diphosphorylase activity
THECO_RS05515	COG2022	thiamine diphosphate biosynthetic process
THECO_RS05520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THECO_RS05525	COG0351	phosphomethylpyrimidine kinase
THECO_RS05560	COG1216	Glycosyl transferase, family 2
THECO_RS05560	COG1442	glycosyl transferase family 8
THECO_RS05565	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
THECO_RS05575	COG1215	transferase activity, transferring glycosyl groups
THECO_RS05600	COG4641	Protein conserved in bacteria
THECO_RS05610	COG0438	transferase activity, transferring glycosyl groups
THECO_RS05620	COG1086	Polysaccharide biosynthesis protein
THECO_RS05635	COG0463	Glycosyl transferase, family 2
THECO_RS05635	COG1216	Glycosyl transferase, family 2
THECO_RS05640	COG1216	Glycosyl transferase, family 2
THECO_RS05650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THECO_RS05700	COG0450	alkyl hydroperoxide reductase
THECO_RS05705	COG3634	alkyl hydroperoxide reductase activity
THECO_RS05715	COG0395	ABC-type sugar transport system, permease component
THECO_RS05720	COG1175	transmembrane transport
THECO_RS05735	COG1349	DNA-binding transcription factor activity
THECO_RS05750	COG2972	Histidine kinase
THECO_RS05760	COG4209	transmembrane transport
THECO_RS05765	COG0395	ABC-type sugar transport system, permease component
THECO_RS05790	COG0494	nUDIX hydrolase
THECO_RS05805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THECO_RS05810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THECO_RS05865	COG3344	reverse transcriptase
THECO_RS05880	COG3189	MarR family transcriptional regulator
THECO_RS05890	COG1794	racemase activity, acting on amino acids and derivatives
THECO_RS05895	COG3401	FG-GAP repeat protein
THECO_RS05900	COG4209	transmembrane transport
THECO_RS05905	COG0395	ABC-type sugar transport system, permease component
THECO_RS05910	COG1653	transport
THECO_RS05915	COG2207	Transcriptional regulator
THECO_RS05925	COG2755	lipolytic protein G-D-S-L family
THECO_RS05935	COG1960	acyl-CoA dehydrogenase activity
THECO_RS05940	COG0673	inositol 2-dehydrogenase activity
THECO_RS05955	COG0673	inositol 2-dehydrogenase activity
THECO_RS05965	COG4209	transmembrane transport
THECO_RS05970	COG0395	ABC-type sugar transport system, permease component
THECO_RS05980	COG2972	Histidine kinase
THECO_RS05985	COG2207	Transcriptional regulator
THECO_RS05985	COG4753	response regulator
THECO_RS06000	COG1760	l-serine dehydratase
THECO_RS06005	COG1760	l-serine dehydratase
THECO_RS06010	COG1473	amidohydrolase
THECO_RS06015	COG0445	tRNA wobble uridine modification
THECO_RS06020	COG0604	alcohol dehydrogenase
THECO_RS06025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
THECO_RS06030	COG0363	glucosamine-6-phosphate deaminase activity
THECO_RS06045	COG4209	transmembrane transport
THECO_RS06050	COG0395	ABC-type sugar transport system, permease component
THECO_RS06055	COG2169	Transcriptional regulator
THECO_RS06060	COG1940	carbohydrate kinase activity
THECO_RS06075	COG1904	glucuronate isomerase
THECO_RS06085	COG0673	inositol 2-dehydrogenase activity
THECO_RS06090	COG2972	Histidine kinase
THECO_RS06095	COG2207	Transcriptional regulator
THECO_RS06095	COG4753	response regulator
THECO_RS06100	COG1653	transport
THECO_RS06105	COG1175	transmembrane transport
THECO_RS06110	COG0395	ABC-type sugar transport system, permease component
THECO_RS06115	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
THECO_RS06125	COG3347	Dehydrogenase
THECO_RS06125	COG1028	Short-chain dehydrogenase reductase Sdr
THECO_RS06135	COG4806	L-rhamnose isomerase
THECO_RS06140	COG1070	Carbohydrate kinase
THECO_RS06145	COG1349	DNA-binding transcription factor activity
THECO_RS06155	COG1139	Iron-sulfur cluster binding protein
THECO_RS06170	COG0723	plastoquinol--plastocyanin reductase activity
THECO_RS06170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THECO_RS06190	COG1129	ABC transporter
THECO_RS06195	COG1172	Belongs to the binding-protein-dependent transport system permease family
THECO_RS06210	COG3959	Transketolase, thiamine diphosphate binding domain
THECO_RS06215	COG3958	Transketolase
THECO_RS06220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
THECO_RS06225	COG2972	Histidine kinase
THECO_RS06230	COG4753	response regulator
THECO_RS06230	COG2207	Transcriptional regulator
THECO_RS06240	COG1175	transmembrane transport
THECO_RS06245	COG0395	ABC-type sugar transport system, permease component
THECO_RS06255	COG2197	response regulator
THECO_RS06270	COG1028	Short-chain dehydrogenase reductase Sdr
THECO_RS06300	COG0385	Bile acid
THECO_RS06305	COG5002	protein histidine kinase activity
THECO_RS06310	COG0745	RESPONSE REGULATOR receiver
THECO_RS06325	COG2268	Band 7 protein
THECO_RS06345	COG2205	protein histidine kinase activity
THECO_RS06350	COG1940	carbohydrate kinase activity
THECO_RS06370	COG2151	metal-sulfur cluster biosynthetic enzyme
THECO_RS06390	COG2115	Belongs to the xylose isomerase family
THECO_RS06395	COG1070	Carbohydrate kinase
THECO_RS06405	COG0546	phosphoglycolate phosphatase activity
THECO_RS06445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THECO_RS06450	COG0573	inorganic phosphate transmembrane transporter activity
THECO_RS06455	COG0581	inorganic phosphate transmembrane transporter activity
THECO_RS06465	COG0704	Plays a role in the regulation of phosphate uptake
THECO_RS06485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THECO_RS06490	COG1971	Probably functions as a manganese efflux pump
THECO_RS06495	COG0237	dephospho-CoA kinase activity
THECO_RS06500	COG0741	lytic transglycosylase activity
THECO_RS06510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THECO_RS06530	COG0583	DNA-binding transcription factor activity
THECO_RS06535	COG0454	-acetyltransferase
THECO_RS06555	COG2182	Extracellular solute-binding protein
THECO_RS06560	COG1175	transmembrane transport
THECO_RS06575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THECO_RS06615	COG1609	Transcriptional regulator
THECO_RS06620	COG2972	Histidine kinase
THECO_RS06625	COG4209	transmembrane transport
THECO_RS06630	COG0395	ABC-type sugar transport system, permease component
THECO_RS06635	COG1653	transport
THECO_RS06650	COG4753	response regulator
THECO_RS06650	COG2207	Transcriptional regulator
THECO_RS06655	COG2207	Transcriptional regulator
THECO_RS06655	COG4753	response regulator
THECO_RS06660	COG2972	Histidine kinase
THECO_RS06665	COG4753	response regulator
THECO_RS06665	COG2207	Transcriptional regulator
THECO_RS06675	COG4209	transmembrane transport
THECO_RS06680	COG0395	ABC-type sugar transport system, permease component
THECO_RS06685	COG0475	glutathione-regulated potassium exporter activity
THECO_RS06690	COG0490	domain, Protein
THECO_RS06695	COG3344	reverse transcriptase
THECO_RS06700	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THECO_RS06745	COG2445	Protein of unknown function DUF86
THECO_RS06765	COG2207	Transcriptional regulator
THECO_RS06765	COG4753	response regulator
THECO_RS06780	COG4844	belongs to the
THECO_RS06785	COG1368	sulfuric ester hydrolase activity
THECO_RS06790	COG4122	O-methyltransferase activity
THECO_RS06795	COG2814	Major facilitator Superfamily
THECO_RS06800	COG0805	protein transport
THECO_RS06805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THECO_RS06820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THECO_RS06820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THECO_RS06825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THECO_RS06830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THECO_RS06835	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
THECO_RS06840	COG2843	Capsule synthesis protein
THECO_RS06850	COG3437	response regulator, receiver
THECO_RS06850	COG0784	Response regulator, receiver
THECO_RS06860	COG1136	(ABC) transporter
THECO_RS06870	COG0577	efflux transmembrane transporter activity
THECO_RS06875	COG1136	(ABC) transporter
THECO_RS06875	COG0577	efflux transmembrane transporter activity
THECO_RS06880	COG1164	Oligoendopeptidase f
THECO_RS06905	COG0217	transcriptional regulatory protein
THECO_RS06910	COG0778	Nitroreductase
THECO_RS06940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THECO_RS06945	COG0513	Belongs to the DEAD box helicase family
THECO_RS06950	COG5578	integral membrane protein
THECO_RS06960	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
THECO_RS06965	COG0705	Rhomboid family
THECO_RS06970	COG0583	DNA-binding transcription factor activity
THECO_RS06975	COG2738	Putative neutral zinc metallopeptidase
THECO_RS06980	COG0789	Transcriptional regulator
THECO_RS06985	COG0004	ammonium transporteR
THECO_RS06995	COG2176	DNA-directed DNA polymerase activity
THECO_RS07005	COG2814	Major facilitator Superfamily
THECO_RS07015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THECO_RS07025	COG1141	Ferredoxin
THECO_RS07040	COG1376	ErfK ybiS ycfS ynhG family protein
THECO_RS07045	COG0167	dihydroorotate dehydrogenase activity
THECO_RS07050	COG2357	RelA SpoT domain protein
THECO_RS07055	COG1547	Domain of unknown function (DUF309)
THECO_RS07065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THECO_RS07070	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THECO_RS07070	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
THECO_RS07075	COG1187	pseudouridine synthase activity
THECO_RS07080	COG0561	phosphatase activity
THECO_RS07085	COG3344	reverse transcriptase
THECO_RS07090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THECO_RS07090	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
THECO_RS07115	COG3706	GGDEF domain
THECO_RS07125	COG0420	3'-5' exonuclease activity
THECO_RS07145	COG3949	Membrane
THECO_RS07155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THECO_RS07175	COG0860	N-Acetylmuramoyl-L-alanine amidase
THECO_RS07195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THECO_RS07205	COG2514	catechol 2,3-dioxygenase activity
THECO_RS07225	COG2197	response regulator
THECO_RS07235	COG1131	(ABC) transporter
THECO_RS07260	COG0840	transmembrane signaling receptor activity
THECO_RS07290	COG1063	alcohol dehydrogenase
THECO_RS07315	COG0673	inositol 2-dehydrogenase activity
THECO_RS07320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THECO_RS07335	COG1486	melibiose metabolic process
THECO_RS07340	COG4977	sequence-specific DNA binding
THECO_RS07345	COG1501	Belongs to the glycosyl hydrolase 31 family
THECO_RS07395	COG4372	Transposase
THECO_RS07405	COG2972	Histidine kinase
THECO_RS07410	COG4753	response regulator
THECO_RS07410	COG2207	Transcriptional regulator
THECO_RS07420	COG1175	transmembrane transport
THECO_RS07425	COG0395	ABC-type sugar transport system, permease component
THECO_RS07485	COG3226	Transcriptional regulator
THECO_RS07495	COG1472	Belongs to the glycosyl hydrolase 3 family
THECO_RS07510	COG2972	Histidine kinase
THECO_RS07520	COG4209	transmembrane transport
THECO_RS07525	COG0395	ABC-type sugar transport system, permease component
THECO_RS07555	COG4124	Belongs to the glycosyl hydrolase 26 family
THECO_RS07565	COG1940	carbohydrate kinase activity
THECO_RS07570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
THECO_RS07595	COG0778	Nitroreductase
THECO_RS07600	COG3973	AAA domain
THECO_RS07610	COG2814	Major facilitator Superfamily
THECO_RS07620	COG1968	undecaprenyl-diphosphatase activity
THECO_RS07625	COG0393	Putative heavy-metal-binding
THECO_RS07650	COG0714	Associated with various cellular activities
THECO_RS07675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THECO_RS07680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THECO_RS07685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THECO_RS07690	COG1120	ATPase activity
THECO_RS07695	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
THECO_RS07705	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
THECO_RS07710	COG1643	Atp-dependent helicase
THECO_RS07760	COG0673	inositol 2-dehydrogenase activity
THECO_RS07765	COG3622	Belongs to the hyi family
THECO_RS07770	COG0534	Mate efflux family protein
THECO_RS07785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THECO_RS07800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THECO_RS07805	COG0622	Phosphoesterase
THECO_RS07810	COG1408	metallophosphoesterase
THECO_RS07815	COG2322	membrane
THECO_RS07840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THECO_RS07845	COG0725	ABC transporter, periplasmic molybdate-binding protein
THECO_RS07850	COG1979	alcohol dehydrogenase
THECO_RS07860	COG0714	Associated with various cellular activities
THECO_RS07880	COG4974	Belongs to the 'phage' integrase family
THECO_RS07910	COG1175	transmembrane transport
THECO_RS07915	COG0395	ABC-type sugar transport system, permease component
THECO_RS07920	COG3275	phosphorelay sensor kinase activity
THECO_RS07925	COG0745	RESPONSE REGULATOR receiver
THECO_RS07930	COG1472	Belongs to the glycosyl hydrolase 3 family
THECO_RS07935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
THECO_RS07940	COG1940	carbohydrate kinase activity
THECO_RS07945	COG0363	glucosamine-6-phosphate deaminase activity
THECO_RS07975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THECO_RS07980	COG0667	Aldo Keto reductase
THECO_RS07995	COG0517	IMP dehydrogenase activity
THECO_RS07995	COG4175	Glycine betaine
THECO_RS08000	COG1510	regulation of RNA biosynthetic process
THECO_RS08025	COG0640	Transcriptional regulator
THECO_RS08050	COG1733	regulation of RNA biosynthetic process
THECO_RS08055	COG0604	alcohol dehydrogenase
THECO_RS08055	COG3321	synthase
THECO_RS08060	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
THECO_RS08065	COG0395	ABC-type sugar transport system, permease component
THECO_RS08070	COG1175	transmembrane transport
THECO_RS08075	COG1653	transport
THECO_RS08080	COG2207	Transcriptional regulator
THECO_RS08080	COG4753	response regulator
THECO_RS08085	COG2972	Histidine kinase
THECO_RS08090	COG0697	spore germination
THECO_RS08115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THECO_RS08125	COG0667	Aldo Keto reductase
THECO_RS08130	COG4193	domain, Protein
THECO_RS08130	COG5263	repeat protein
THECO_RS08140	COG1175	transmembrane transport
THECO_RS08145	COG3842	ATPase activity
THECO_RS08150	COG2182	Extracellular solute-binding protein
THECO_RS08155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
THECO_RS08160	COG2340	Cysteine-rich secretory protein family
THECO_RS08165	COG2311	Membrane
THECO_RS08170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
THECO_RS08175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THECO_RS08180	COG0583	DNA-binding transcription factor activity
THECO_RS08195	COG3546	catalase activity
THECO_RS08205	COG1227	inorganic diphosphatase activity
THECO_RS08215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
THECO_RS08235	COG4948	Mandelate Racemase Muconate Lactonizing
THECO_RS08240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THECO_RS08245	COG0667	Aldo Keto reductase
THECO_RS08265	COG1929	Belongs to the glycerate kinase type-1 family
THECO_RS08280	COG0667	Aldo Keto reductase
THECO_RS08295	COG0492	ferredoxin-NADP+ reductase activity
THECO_RS08300	COG3458	cephalosporin-C deacetylase activity
THECO_RS08310	COG0674	pyruvate-flavodoxin oxidoreductase activity
THECO_RS08320	COG1028	Short-chain dehydrogenase reductase Sdr
THECO_RS08325	COG2258	MOSC domain
THECO_RS08360	COG0493	'glutamate synthase
THECO_RS08365	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
THECO_RS08370	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
THECO_RS08375	COG1607	acyl-coa hydrolase
THECO_RS08405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THECO_RS08410	COG2860	membrane
THECO_RS08420	COG3402	PFAM membrane-flanked domain
THECO_RS08425	COG3428	Bacterial PH domain
THECO_RS08430	COG0321	lipoyl(octanoyl) transferase activity
THECO_RS08430	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
THECO_RS08440	COG0456	acetyltransferase
THECO_RS08445	COG0791	NLP P60 protein
THECO_RS08450	COG5002	protein histidine kinase activity
THECO_RS08450	COG3850	Histidine kinase
THECO_RS08455	COG0745	RESPONSE REGULATOR receiver
THECO_RS08465	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
THECO_RS08470	COG1119	ATPase activity
THECO_RS08480	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THECO_RS08485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THECO_RS08495	COG1111	helicase
THECO_RS08495	COG1205	dead DEAH box helicase
THECO_RS08505	COG1234	tRNA 3'-trailer cleavage
THECO_RS08510	COG1410	methionine synthase
THECO_RS08510	COG0646	methionine synthase
THECO_RS08515	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
THECO_RS08520	COG1011	Hydrolase
THECO_RS08530	COG4224	UPF0291 protein
THECO_RS08540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THECO_RS08545	COG0174	glutamine synthetase
THECO_RS08550	COG0789	Transcriptional regulator
THECO_RS08555	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
THECO_RS08560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THECO_RS08565	COG0464	growth
THECO_RS08580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THECO_RS08585	COG1923	regulation of RNA biosynthetic process
THECO_RS08590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THECO_RS08595	COG2521	methyltransferase
THECO_RS08595	COG2136	Putative SAM-dependent methyltransferase
THECO_RS08600	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THECO_RS08605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THECO_RS08620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THECO_RS08625	COG1116	anion transmembrane transporter activity
THECO_RS08630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THECO_RS08635	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
THECO_RS08640	COG4918	Iron-sulphur cluster biosynthesis
THECO_RS08650	COG1547	Domain of unknown function (DUF309)
THECO_RS08665	COG3858	chitin binding
THECO_RS08685	COG0840	transmembrane signaling receptor activity
THECO_RS08705	COG1846	Transcriptional regulator
THECO_RS08710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THECO_RS08715	COG0187	DNA topoisomerase II activity
THECO_RS08720	COG1132	(ABC) transporter
THECO_RS08725	COG1132	(ABC) transporter
THECO_RS08730	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
THECO_RS08740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THECO_RS08755	COG0860	N-Acetylmuramoyl-L-alanine amidase
THECO_RS08760	COG0066	3-isopropylmalate dehydratase activity
THECO_RS08765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THECO_RS08770	COG0583	DNA-binding transcription factor activity
THECO_RS08775	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THECO_RS08780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THECO_RS08790	COG0436	Aminotransferase
THECO_RS08795	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THECO_RS08800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THECO_RS08805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THECO_RS08810	COG1850	ribulose-bisphosphate carboxylase activity
THECO_RS08815	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
THECO_RS08820	COG0235	Class ii aldolase
THECO_RS08825	COG3935	DnaD domain protein
THECO_RS08830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THECO_RS08835	COG1250	3-hydroxyacyl-CoA dehydrogenase
THECO_RS08840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THECO_RS08855	COG0402	S-adenosylhomocysteine deaminase activity
THECO_RS08860	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
THECO_RS08865	COG1199	ATP-dependent helicase activity
THECO_RS08865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THECO_RS08875	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THECO_RS08880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THECO_RS08885	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THECO_RS08895	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THECO_RS08895	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THECO_RS08905	COG0438	transferase activity, transferring glycosyl groups
THECO_RS08915	COG1803	Methylglyoxal synthase
THECO_RS08920	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THECO_RS08930	COG1694	Mazg nucleotide pyrophosphohydrolase
THECO_RS08935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THECO_RS08945	COG4347	Protein of unknown function (DUF1405)
THECO_RS08955	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THECO_RS08975	COG0406	alpha-ribazole phosphatase activity
THECO_RS08990	COG0287	Prephenate dehydrogenase
THECO_RS08995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THECO_RS09000	COG0159	tryptophan synthase activity
THECO_RS09005	COG0133	tryptophan synthase activity
THECO_RS09010	COG0135	phosphoribosylanthranilate isomerase activity
THECO_RS09015	COG0134	indole-3-glycerol-phosphate synthase activity
THECO_RS09020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THECO_RS09030	COG4401	Chorismate mutase type I
THECO_RS09035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THECO_RS09040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THECO_RS09045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THECO_RS09060	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
THECO_RS09065	COG0163	prenyltransferase activity
THECO_RS09070	COG0109	protoheme IX farnesyltransferase activity
THECO_RS09075	COG2226	methyltransferase
THECO_RS09100	COG0776	regulation of translation
THECO_RS09105	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
THECO_RS09140	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THECO_RS09145	COG1160	GTP binding
THECO_RS09165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THECO_RS09175	COG2959	enzyme of heme biosynthesis
THECO_RS09185	COG2339	peptidase activity
THECO_RS09190	COG4862	establishment of competence for transformation
THECO_RS09205	COG1408	metallophosphoesterase
THECO_RS09215	COG1266	CAAX protease self-immunity
THECO_RS09225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THECO_RS09230	COG5002	protein histidine kinase activity
THECO_RS09235	COG0745	RESPONSE REGULATOR receiver
THECO_RS09240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THECO_RS09245	COG1333	cytochrome c biogenesis protein
THECO_RS09250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THECO_RS09255	COG1187	pseudouridine synthase activity
THECO_RS09260	COG0700	Nucleoside recognition
THECO_RS09265	COG2715	membrane protein required for spore maturation
THECO_RS09270	COG1686	Belongs to the peptidase S11 family
THECO_RS09275	COG3874	Sporulation protein YtfJ
THECO_RS09285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THECO_RS09290	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
THECO_RS09295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THECO_RS09300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THECO_RS09300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THECO_RS09310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THECO_RS09310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THECO_RS09320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THECO_RS09325	COG0019	diaminopimelate decarboxylase activity
THECO_RS09330	COG0697	spore germination
THECO_RS09345	COG3344	reverse transcriptase
THECO_RS09355	COG2172	sigma factor antagonist activity
THECO_RS09360	COG1366	Belongs to the anti-sigma-factor antagonist family
THECO_RS09365	COG1686	Belongs to the peptidase S11 family
THECO_RS09415	COG1132	(ABC) transporter
THECO_RS09445	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
THECO_RS09460	COG0735	belongs to the Fur family
THECO_RS09465	COG1300	Membrane
THECO_RS09470	COG1379	DNA repair
THECO_RS09505	COG2195	Cleaves the N-terminal amino acid of tripeptides
THECO_RS09510	COG0321	lipoyl(octanoyl) transferase activity
THECO_RS09515	COG0508	dehydrogenase complex catalyzes the overall conversion of
THECO_RS09520	COG0022	dehydrogenase e1 component
THECO_RS09525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
THECO_RS09530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THECO_RS09550	COG0745	RESPONSE REGULATOR receiver
THECO_RS09555	COG0750	zinc metalloprotease
THECO_RS09560	COG0497	DNA recombination
THECO_RS09565	COG1438	arginine binding
THECO_RS09575	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
THECO_RS09580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THECO_RS09590	COG1722	exodeoxyribonuclease VII activity
THECO_RS09595	COG1570	exodeoxyribonuclease VII activity
THECO_RS09600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THECO_RS09605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THECO_RS09620	COG1302	Protein conserved in bacteria
THECO_RS09625	COG0439	Biotin carboxylase
THECO_RS09630	COG0511	ligase activity, forming carbon-carbon bonds
THECO_RS09670	COG3854	ATPases associated with a variety of cellular activities
THECO_RS09680	COG1809	phosphosulfolactate synthase activity
THECO_RS09685	COG2707	UPF0756 membrane protein
THECO_RS09695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THECO_RS09700	COG0006	proline dipeptidase activity
THECO_RS09705	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THECO_RS09710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
THECO_RS09725	COG3872	metal-dependent enzyme
THECO_RS09735	COG1321	iron dependent repressor
THECO_RS09740	COG0785	Cytochrome C biogenesis protein
THECO_RS09745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THECO_RS09750	COG1121	(ABC) transporter
THECO_RS09755	COG3443	Belongs to the bacterial solute-binding protein 9 family
THECO_RS09755	COG0803	Belongs to the bacterial solute-binding protein 9 family
THECO_RS09765	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THECO_RS09770	COG0735	belongs to the Fur family
THECO_RS09790	COG1132	(ABC) transporter
THECO_RS09810	COG1268	BioY protein
THECO_RS09815	COG4550	Control of competence regulator ComK, YlbF/YmcA
THECO_RS09820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THECO_RS09825	COG4869	propanediol catabolic process
THECO_RS09830	COG1013	pyruvate-flavodoxin oxidoreductase activity
THECO_RS09835	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THECO_RS09835	COG0674	pyruvate-flavodoxin oxidoreductase activity
THECO_RS09845	COG2359	stage V sporulation protein S
THECO_RS09850	COG1692	metallophosphoesterase
THECO_RS09855	COG1418	mRNA catabolic process
THECO_RS09860	COG2137	regulation of response to DNA damage stimulus
THECO_RS09865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THECO_RS09870	COG1058	Belongs to the CinA family
THECO_RS09870	COG1546	Belongs to the CinA family
THECO_RS09875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THECO_RS09880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THECO_RS09890	COG1426	Protein conserved in bacteria
THECO_RS09905	COG0300	oxidoreductase activity
THECO_RS09910	COG0612	Peptidase, M16
THECO_RS09915	COG0612	Peptidase, M16
THECO_RS09925	COG4980	gas vesicle protein
THECO_RS09925	COG1674	ftsk spoiiie
THECO_RS09935	COG0740	serine-type endopeptidase activity
THECO_RS09940	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
THECO_RS09950	COG0527	aspartate kinase activity
THECO_RS09955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THECO_RS09960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THECO_RS09965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THECO_RS09970	COG0756	dUTP diphosphatase activity
THECO_RS09975	COG0612	Peptidase, M16
THECO_RS09985	COG1185	polyribonucleotide nucleotidyltransferase activity
THECO_RS09990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THECO_RS09995	COG0196	riboflavin kinase activity
THECO_RS10000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THECO_RS10005	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THECO_RS10010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THECO_RS10015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THECO_RS10015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THECO_RS10025	COG2740	Nucleic-acid-binding protein implicated in transcription termination
THECO_RS10030	COG0195	Participates in both transcription termination and antitermination
THECO_RS10035	COG0779	Required for maturation of 30S ribosomal subunits
THECO_RS10040	COG2176	DNA-directed DNA polymerase activity
THECO_RS10045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THECO_RS10050	COG0750	zinc metalloprotease
THECO_RS10055	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THECO_RS10060	COG4589	Belongs to the CDS family
THECO_RS10065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THECO_RS10070	COG0233	cytoplasmic translational termination
THECO_RS10075	COG0528	UMP kinase activity
THECO_RS10080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THECO_RS10085	COG0052	Belongs to the universal ribosomal protein uS2 family
THECO_RS10110	COG1191	sigma factor activity
THECO_RS10120	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THECO_RS10125	COG1776	CheC inhibitor of MCP methylation
THECO_RS10130	COG0835	chemotaxis
THECO_RS10135	COG2198	Histidine kinase
THECO_RS10135	COG0643	Histidine kinase
THECO_RS10140	COG2201	protein-glutamate methylesterase activity
THECO_RS10145	COG0455	bacterial-type flagellum organization
THECO_RS10150	COG1419	protein localization to endoplasmic reticulum
THECO_RS10155	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THECO_RS10160	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THECO_RS10165	COG1684	flagellar biosynthetic protein fliR
THECO_RS10170	COG1987	bacterial-type flagellum assembly
THECO_RS10175	COG1338	Plays a role in the flagellum-specific transport system
THECO_RS10185	COG2201	protein-glutamate methylesterase activity
THECO_RS10190	COG1776	CheC inhibitor of MCP methylation
THECO_RS10190	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THECO_RS10195	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THECO_RS10210	COG4786	Flagellar basal body rod
THECO_RS10220	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THECO_RS10245	COG1157	protein secretion by the type III secretion system
THECO_RS10255	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THECO_RS10260	COG1766	The M ring may be actively involved in energy transduction
THECO_RS10265	COG1677	Flagellar hook-basal body complex protein FliE
THECO_RS10270	COG1558	bacterial-type flagellum-dependent cell motility
THECO_RS10275	COG1815	bacterial-type flagellum-dependent cell motility
THECO_RS10285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THECO_RS10290	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THECO_RS10295	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
THECO_RS10300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THECO_RS10305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THECO_RS10305	COG0758	DNA mediated transformation
THECO_RS10310	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THECO_RS10315	COG0045	succinate-CoA ligase (ADP-forming) activity
THECO_RS10330	COG0792	nuclease activity
THECO_RS10345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THECO_RS10370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THECO_RS10375	COG1837	Belongs to the UPF0109 family
THECO_RS10380	COG0228	four-way junction DNA binding
THECO_RS10385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THECO_RS10390	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
THECO_RS10395	COG0552	protein localization to endoplasmic reticulum
THECO_RS10400	COG1196	nuclear chromosome segregation
THECO_RS10405	COG0571	ribonuclease III activity
THECO_RS10410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THECO_RS10415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THECO_RS10420	COG1028	Short-chain dehydrogenase reductase Sdr
THECO_RS10425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THECO_RS10430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THECO_RS10435	COG0416	fatty acid biosynthetic process
THECO_RS10440	COG1349	DNA-binding transcription factor activity
THECO_RS10445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THECO_RS10455	COG1323	Belongs to the UPF0348 family
THECO_RS10460	COG3480	Lon protease (S16) C-terminal proteolytic domain
THECO_RS10465	COG3314	Sporulation integral membrane protein YlbJ
THECO_RS10470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THECO_RS10475	COG0742	ribosomal rna small subunit methyltransferase
THECO_RS10480	COG3344	reverse transcriptase
THECO_RS10495	COG0084	hydrolase, TatD family'
THECO_RS10505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THECO_RS10515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THECO_RS10520	COG0457	Tetratricopeptide repeat
THECO_RS10520	COG0463	Glycosyl transferase, family 2
THECO_RS10535	COG1086	Polysaccharide biosynthesis protein
THECO_RS10560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THECO_RS10565	COG2135	peptidase activity
THECO_RS10575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THECO_RS10580	COG1307	EDD domain protein, DegV family
THECO_RS10585	COG1461	Dihydroxyacetone kinase
THECO_RS10590	COG1302	Protein conserved in bacteria
THECO_RS10595	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THECO_RS10600	COG3344	reverse transcriptase
THECO_RS10615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THECO_RS10620	COG1162	GTPase activity
THECO_RS10625	COG2815	serine threonine protein kinase
THECO_RS10625	COG0515	serine threonine protein kinase
THECO_RS10630	COG0631	protein serine/threonine phosphatase activity
THECO_RS10635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THECO_RS10640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THECO_RS10640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THECO_RS10650	COG0242	peptide deformylase activity
THECO_RS10655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THECO_RS10660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THECO_RS10665	COG1758	RNA polymerase activity
THECO_RS10670	COG0194	GDP metabolic process
THECO_RS10675	COG2052	Domain of unknown function (DUF370)
THECO_RS10680	COG0646	methionine synthase
THECO_RS10680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THECO_RS10690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THECO_RS10695	COG1293	RNA-binding protein homologous to eukaryotic snRNP
THECO_RS10700	COG0613	PHP domain protein
THECO_RS10705	COG0583	DNA-binding transcription factor activity
THECO_RS10715	COG4471	UPF0298 protein
THECO_RS10730	COG1061	Type III restriction enzyme res subunit
THECO_RS10735	COG0228	four-way junction DNA binding
THECO_RS10740	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
THECO_RS10745	COG1473	amidohydrolase
THECO_RS10755	COG0772	Belongs to the SEDS family
THECO_RS10760	COG1302	Protein conserved in bacteria
THECO_RS10765	COG4838	Belongs to the UPF0358 family
THECO_RS10775	COG2309	aminopeptidase activity
THECO_RS10785	COG2203	Gaf domain
THECO_RS10785	COG2199	diguanylate cyclase activity
THECO_RS10790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THECO_RS10795	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THECO_RS10800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THECO_RS10805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THECO_RS10815	COG0123	including yeast histone deacetylase and acetoin utilization protein
THECO_RS10825	COG0123	including yeast histone deacetylase and acetoin utilization protein
THECO_RS10830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THECO_RS10840	COG1648	precorrin-2 dehydrogenase activity
THECO_RS10840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THECO_RS10850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THECO_RS10855	COG1263	PTS System
THECO_RS10855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THECO_RS10855	COG2190	(PTS) system
THECO_RS10865	COG1832	CoA-binding protein
THECO_RS10870	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THECO_RS10875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THECO_RS10880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THECO_RS10885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THECO_RS10895	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THECO_RS10900	COG1070	Carbohydrate kinase
THECO_RS10915	COG1982	Orn Lys Arg decarboxylase major
THECO_RS10940	COG1234	tRNA 3'-trailer cleavage
THECO_RS11010	COG1136	(ABC) transporter
THECO_RS11010	COG0577	efflux transmembrane transporter activity
THECO_RS11025	COG1136	(ABC) transporter
THECO_RS11035	COG1131	(ABC) transporter
THECO_RS11045	COG4124	Belongs to the glycosyl hydrolase 26 family
THECO_RS11050	COG4124	Belongs to the glycosyl hydrolase 26 family
THECO_RS11055	COG0395	ABC-type sugar transport system, permease component
THECO_RS11060	COG1175	transmembrane transport
THECO_RS11080	COG0395	ABC-type sugar transport system, permease component
THECO_RS11090	COG1653	transport
THECO_RS11100	COG1609	Transcriptional regulator
THECO_RS11110	COG0577	efflux transmembrane transporter activity
THECO_RS11120	COG1136	(ABC) transporter
THECO_RS11130	COG3459	Glycosyltransferase 36 associated
THECO_RS11140	COG1175	transmembrane transport
THECO_RS11145	COG0395	ABC-type sugar transport system, permease component
THECO_RS11150	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THECO_RS11155	COG0284	orotidine-5'-phosphate decarboxylase activity
THECO_RS11160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THECO_RS11170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THECO_RS11175	COG0540	Belongs to the ATCase OTCase family
THECO_RS11190	COG0564	pseudouridine synthase activity
THECO_RS11195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THECO_RS11200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THECO_RS11220	COG3599	regulation of cell shape
THECO_RS11225	COG2302	S4 RNA-binding domain
THECO_RS11230	COG0762	integral membrane protein
THECO_RS11235	COG1799	cell septum assembly
THECO_RS11240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THECO_RS11245	COG1496	oxidoreductase activity
THECO_RS11250	COG1873	PFAM PRC-barrel domain
THECO_RS11255	COG1191	sigma factor activity
THECO_RS11260	COG1191	sigma factor activity
THECO_RS11270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THECO_RS11275	COG0849	cell division
THECO_RS11280	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
THECO_RS11285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THECO_RS11290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THECO_RS11295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THECO_RS11300	COG0772	Belongs to the SEDS family
THECO_RS11305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THECO_RS11310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THECO_RS11315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THECO_RS11320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THECO_RS11325	COG0768	penicillin binding
THECO_RS11330	COG0768	penicillin binding
THECO_RS11340	COG0275	rRNA processing
THECO_RS11345	COG2001	Belongs to the MraZ family
THECO_RS11350	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THECO_RS11355	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
THECO_RS11365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
THECO_RS11390	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THECO_RS11405	COG1316	TRANSCRIPTIONal
THECO_RS11420	COG1217	gtp-binding protein TYPA
THECO_RS11430	COG0861	Integral membrane protein TerC family
THECO_RS11435	COG0861	Integral membrane protein TerC family
THECO_RS11440	COG0301	tRNA thio-modification
THECO_RS11445	COG1104	cysteine desulfurase activity
THECO_RS11450	COG0741	lytic transglycosylase activity
THECO_RS11475	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THECO_RS11480	COG2384	SAM-dependent methyltransferase
THECO_RS11495	COG0358	DNA primase activity
THECO_RS11500	COG1671	Belongs to the UPF0178 family
THECO_RS11505	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
THECO_RS11510	COG0751	glycine-tRNA ligase activity
THECO_RS11515	COG0752	glycyl-tRNA synthetase alpha subunit
THECO_RS11520	COG1381	Involved in DNA repair and RecF pathway recombination
THECO_RS11525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THECO_RS11535	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THECO_RS11540	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THECO_RS11545	COG1480	7TM receptor with intracellular HD hydrolase
THECO_RS11550	COG1702	phosphate starvation-inducible protein PhoH
THECO_RS11570	COG4864	UPF0365 protein
THECO_RS11575	COG1030	water channel activity
THECO_RS11585	COG1610	YqeY-like protein
THECO_RS11590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THECO_RS11595	COG0537	adenosine 5'-monophosphoramidase activity
THECO_RS11610	COG0419	ATPase involved in DNA repair
THECO_RS11615	COG0420	3'-5' exonuclease activity
THECO_RS11620	COG1074	ATP-dependent DNA helicase activity
THECO_RS11625	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
THECO_RS11630	COG0584	glycerophosphoryl diester phosphodiesterase
THECO_RS11635	COG3250	beta-galactosidase activity
THECO_RS11640	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
THECO_RS11645	COG1335	isochorismatase
THECO_RS11655	COG1283	sodium-dependent phosphate transmembrane transporter activity
THECO_RS11660	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
THECO_RS11670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THECO_RS11675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THECO_RS11680	COG1994	Peptidase M50
THECO_RS11685	COG2264	protein methyltransferase activity
THECO_RS11700	COG0443	Heat shock 70 kDa protein
THECO_RS11710	COG1420	regulation of RNA biosynthetic process
THECO_RS11715	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THECO_RS11725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THECO_RS11730	COG0481	GTPase activity
THECO_RS11740	COG0860	N-Acetylmuramoyl-L-alanine amidase
THECO_RS11750	COG0268	Binds directly to 16S ribosomal RNA
THECO_RS11755	COG1466	dna polymerase III delta subunit
THECO_RS11765	COG1595	DNA-templated transcription, initiation
THECO_RS11770	COG0658	competence protein
THECO_RS11770	COG2333	competence protein COMEC
THECO_RS11785	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THECO_RS11790	COG0495	leucyl-tRNA aminoacylation
THECO_RS11800	COG2226	methyltransferase
THECO_RS11805	COG2996	Protein conserved in bacteria
THECO_RS11810	COG0799	negative regulation of ribosome biogenesis
THECO_RS11815	COG1713	HD superfamily hydrolase involved in NAD metabolism
THECO_RS11820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THECO_RS11825	COG1534	Rna-binding protein
THECO_RS11830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THECO_RS11835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
THECO_RS11840	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
THECO_RS11855	COG0714	Associated with various cellular activities
THECO_RS11860	COG2826	transposase and inactivated derivatives, IS30 family
THECO_RS11870	COG3344	reverse transcriptase
THECO_RS11880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THECO_RS11890	COG3344	reverse transcriptase
THECO_RS11900	COG1609	Transcriptional regulator
THECO_RS11920	COG1473	amidohydrolase
THECO_RS11925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
THECO_RS11930	COG1126	abc transporter atp-binding protein
THECO_RS11935	COG0765	amino acid transport
THECO_RS11940	COG0765	amino acid transport
THECO_RS11945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THECO_RS11950	COG0456	acetyltransferase
THECO_RS11955	COG0583	DNA-binding transcription factor activity
THECO_RS11960	COG0431	NADPH-dependent FMN reductase
THECO_RS11965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
THECO_RS11980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THECO_RS11985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THECO_RS12020	COG2972	Histidine kinase
THECO_RS12030	COG2207	Transcriptional regulator
THECO_RS12030	COG4753	response regulator
THECO_RS12035	COG0829	nickel cation binding
THECO_RS12040	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
THECO_RS12045	COG0830	nickel cation binding
THECO_RS12050	COG0804	urea catabolic process
THECO_RS12055	COG0832	Belongs to the urease beta subunit family
THECO_RS12060	COG0831	urea catabolic process
THECO_RS12070	COG0129	dihydroxy-acid dehydratase activity
THECO_RS12080	COG0628	permease
THECO_RS12085	COG0768	penicillin binding
THECO_RS12095	COG0826	peptidase U32
THECO_RS12100	COG0826	peptidase U32
THECO_RS12105	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THECO_RS12120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THECO_RS12125	COG4472	Bacterial protein of unknown function (DUF965)
THECO_RS12130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THECO_RS12135	COG0628	permease
THECO_RS12150	COG1104	cysteine desulfurase activity
THECO_RS12155	COG1959	2 iron, 2 sulfur cluster binding
THECO_RS12160	COG0482	sulfurtransferase activity
THECO_RS12165	COG1253	flavin adenine dinucleotide binding
THECO_RS12170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THECO_RS12180	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THECO_RS12185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THECO_RS12190	COG0124	histidyl-tRNA synthetase
THECO_RS12195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THECO_RS12200	COG1490	D-aminoacyl-tRNA deacylase activity
THECO_RS12205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THECO_RS12210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THECO_RS12215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THECO_RS12215	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THECO_RS12230	COG2244	polysaccharide biosynthetic process
THECO_RS12235	COG2323	membrane
THECO_RS12250	COG1862	Preprotein translocase
THECO_RS12255	COG0343	queuine tRNA-ribosyltransferase activity
THECO_RS12265	COG2385	sporulation resulting in formation of a cellular spore
THECO_RS12275	COG2255	four-way junction helicase activity
THECO_RS12280	COG0632	four-way junction helicase activity
THECO_RS12285	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THECO_RS12295	COG3344	reverse transcriptase
THECO_RS12300	COG1388	LysM domain
THECO_RS12300	COG0741	lytic transglycosylase activity
THECO_RS12305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THECO_RS12310	COG0077	Prephenate dehydratase
THECO_RS12315	COG0083	homoserine kinase activity
THECO_RS12320	COG0460	homoserine dehydrogenase
THECO_RS12325	COG4492	Belongs to the UPF0735 family
THECO_RS12330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THECO_RS12340	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THECO_RS12345	COG2868	ribosomal protein
THECO_RS12350	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THECO_RS12360	COG1994	Peptidase M50
THECO_RS12375	COG0772	Belongs to the SEDS family
THECO_RS12380	COG2894	cell division
THECO_RS12385	COG0850	regulation of cytokinetic process
THECO_RS12395	COG1792	Involved in formation and maintenance of cell shape
THECO_RS12400	COG1077	Cell shape determining protein MreB Mrl
THECO_RS12405	COG2003	Belongs to the UPF0758 family
THECO_RS12435	COG0424	maF-like protein
THECO_RS12450	COG2340	Cysteine-rich secretory protein family
THECO_RS12455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THECO_RS12460	COG0285	dihydrofolate synthase activity
THECO_RS12465	COG0525	valine-tRNA ligase activity
THECO_RS12470	COG1388	LysM domain
THECO_RS12475	COG0564	pseudouridine synthase activity
THECO_RS12480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THECO_RS12490	COG0113	porphobilinogen synthase activity
THECO_RS12505	COG1648	precorrin-2 dehydrogenase activity
THECO_RS12505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THECO_RS12510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THECO_RS12520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THECO_RS12530	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THECO_RS12540	COG0470	DNA polymerase III
THECO_RS12540	COG1067	ATP-dependent peptidase activity
THECO_RS12545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THECO_RS12550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THECO_RS12555	COG0740	serine-type endopeptidase activity
THECO_RS12560	COG0544	peptidyl-prolyl cis-trans isomerase activity
THECO_RS12580	COG0367	asparagine synthase
THECO_RS12590	COG2814	Major facilitator Superfamily
THECO_RS12615	COG1172	Belongs to the binding-protein-dependent transport system permease family
THECO_RS12620	COG1129	ABC transporter
THECO_RS12625	COG1879	ABC-type sugar transport system periplasmic component
THECO_RS12650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THECO_RS12650	COG1522	sequence-specific DNA binding
THECO_RS12665	COG0367	asparagine synthase
THECO_RS12670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THECO_RS12675	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THECO_RS12680	COG5401	PFAM Sporulation and spore germination
THECO_RS12685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THECO_RS12690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THECO_RS12705	COG0039	L-malate dehydrogenase activity
THECO_RS12710	COG0538	isocitrate dehydrogenase activity
THECO_RS12715	COG0372	Belongs to the citrate synthase family
THECO_RS12730	COG0825	malonyl-CoA metabolic process
THECO_RS12735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THECO_RS12745	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THECO_RS12750	COG0587	DNA-directed DNA polymerase activity
THECO_RS12775	COG4109	DRTGG domain
THECO_RS12785	COG4399	Belongs to the UPF0754 family
THECO_RS12790	COG0189	ligase activity
THECO_RS12800	COG0189	ligase activity
THECO_RS12805	COG0189	ligase activity
THECO_RS12815	COG0189	ligase activity
THECO_RS12820	COG4106	trans-aconitate 2-methyltransferase activity
THECO_RS12825	COG0402	S-adenosylhomocysteine deaminase activity
THECO_RS12830	COG2249	NAD(P)H dehydrogenase (quinone) activity
THECO_RS12835	COG1733	regulation of RNA biosynthetic process
THECO_RS12840	COG3546	catalase activity
THECO_RS12855	COG0628	permease
THECO_RS12860	COG0535	radical SAM domain protein
THECO_RS12865	COG0737	Belongs to the 5'-nucleotidase family
THECO_RS12870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THECO_RS12875	COG0314	molybdopterin synthase activity
THECO_RS12880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THECO_RS12885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THECO_RS12885	COG2199	diguanylate cyclase activity
THECO_RS12900	COG1705	Flagellar rod assembly protein muramidase FlgJ
THECO_RS12910	COG1595	DNA-templated transcription, initiation
THECO_RS12940	COG0719	Fe-S assembly protein
THECO_RS12945	COG0822	iron-sulfur transferase activity
THECO_RS12950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THECO_RS12955	COG0719	Fe-S assembly protein
THECO_RS12960	COG0396	ATPase activity
THECO_RS12975	COG0612	Peptidase, M16
THECO_RS12980	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
THECO_RS12985	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THECO_RS12990	COG3377	Domain of unknown function (DUF1805)
THECO_RS13005	COG2363	Small membrane protein
THECO_RS13015	COG2718	Belongs to the UPF0229 family
THECO_RS13025	COG0330	HflC and HflK could
THECO_RS13030	COG0330	HflC and HflK could
THECO_RS13035	COG0840	transmembrane signaling receptor activity
THECO_RS13040	COG2719	SpoVR family
THECO_RS13045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THECO_RS13050	COG2766	serine protein kinase
THECO_RS13060	COG2002	toxin-antitoxin pair type II binding
THECO_RS13065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THECO_RS13070	COG0745	RESPONSE REGULATOR receiver
THECO_RS13085	COG0174	glutamine synthetase
THECO_RS13095	COG1309	transcriptional regulator
THECO_RS13100	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THECO_RS13105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THECO_RS13110	COG3850	Histidine kinase
THECO_RS13110	COG5002	protein histidine kinase activity
THECO_RS13115	COG0745	RESPONSE REGULATOR receiver
THECO_RS13120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THECO_RS13130	COG2197	response regulator
THECO_RS13135	COG4585	Histidine kinase
THECO_RS13140	COG4758	membrane
THECO_RS13145	COG0840	transmembrane signaling receptor activity
THECO_RS13150	COG1595	DNA-templated transcription, initiation
THECO_RS13155	COG3584	3D domain protein
THECO_RS13160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THECO_RS13170	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THECO_RS13175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
THECO_RS13180	COG0626	cystathionine gamma-synthase activity
THECO_RS13185	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
THECO_RS13190	COG0598	Magnesium transport protein CorA
THECO_RS13195	COG2270	Major facilitator Superfamily
THECO_RS13215	COG1733	regulation of RNA biosynthetic process
THECO_RS13220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THECO_RS13225	COG1053	succinate dehydrogenase
THECO_RS13230	COG2009	succinate dehydrogenase
THECO_RS13235	COG2826	transposase and inactivated derivatives, IS30 family
THECO_RS13240	COG0583	DNA-binding transcription factor activity
THECO_RS13245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THECO_RS13255	COG3344	reverse transcriptase
THECO_RS13270	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
THECO_RS13275	COG4208	sulfate ABC transporter
THECO_RS13280	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
THECO_RS13285	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
THECO_RS13295	COG1484	DNA-dependent DNA replication
THECO_RS13305	COG0596	Alpha beta hydrolase
THECO_RS13315	COG3253	May function as heme-dependent peroxidase
THECO_RS13325	COG1252	NADH dehydrogenase
THECO_RS13330	COG0492	ferredoxin-NADP+ reductase activity
THECO_RS13345	COG0189	ligase activity
THECO_RS13360	COG1230	cation diffusion facilitator family transporter
THECO_RS13365	COG1126	abc transporter atp-binding protein
THECO_RS13375	COG0765	amino acid transport
THECO_RS13380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THECO_RS13385	COG0477	Major facilitator Superfamily
THECO_RS13390	COG0662	Cupin 2, conserved barrel domain protein
THECO_RS13390	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
THECO_RS13400	COG1063	alcohol dehydrogenase
THECO_RS13405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THECO_RS13405	COG3711	transcriptional antiterminator
THECO_RS13410	COG2213	PTS system mannitol-specific
THECO_RS13415	COG1063	alcohol dehydrogenase
THECO_RS13420	COG0395	ABC-type sugar transport system, permease component
THECO_RS13425	COG1175	transmembrane transport
THECO_RS13440	COG2814	Major facilitator Superfamily
THECO_RS13460	COG5002	protein histidine kinase activity
THECO_RS13470	COG3534	alpha-L-arabinofuranosidase
THECO_RS13475	COG4977	sequence-specific DNA binding
THECO_RS13500	COG4753	response regulator
THECO_RS13500	COG2207	Transcriptional regulator
THECO_RS13510	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
THECO_RS13520	COG0475	glutathione-regulated potassium exporter activity
THECO_RS13525	COG0697	spore germination
THECO_RS13555	COG2010	Cytochrome c
THECO_RS13560	COG0697	spore germination
THECO_RS13575	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
THECO_RS13600	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
THECO_RS13630	COG1061	Type III restriction enzyme res subunit
THECO_RS13650	COG2132	Multicopper oxidase
THECO_RS13655	COG5002	protein histidine kinase activity
THECO_RS13660	COG0745	RESPONSE REGULATOR receiver
THECO_RS13665	COG1028	Short-chain dehydrogenase reductase Sdr
THECO_RS13680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THECO_RS13695	COG1175	transmembrane transport
THECO_RS13705	COG2197	response regulator
THECO_RS13710	COG2972	Histidine kinase
THECO_RS13730	COG2207	Transcriptional regulator
THECO_RS13730	COG1917	Cupin 2, conserved barrel domain protein
THECO_RS13745	COG0395	ABC-type sugar transport system, permease component
THECO_RS13750	COG4209	transmembrane transport
THECO_RS13765	COG1131	(ABC) transporter
THECO_RS13795	COG2814	Major facilitator Superfamily
THECO_RS13805	COG0789	Transcriptional regulator
THECO_RS13815	COG3507	Belongs to the glycosyl hydrolase 43 family
THECO_RS13820	COG3279	Response regulator of the LytR AlgR family
THECO_RS13825	COG2972	Histidine kinase
THECO_RS13840	COG3507	Belongs to the glycosyl hydrolase 43 family
THECO_RS13855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THECO_RS13860	COG0395	ABC-type sugar transport system, permease component
THECO_RS13865	COG1175	transmembrane transport
THECO_RS13885	COG0395	ABC-type sugar transport system, permease component
THECO_RS13890	COG1175	transmembrane transport
THECO_RS13910	COG0534	Mate efflux family protein
THECO_RS13920	COG1595	DNA-templated transcription, initiation
THECO_RS13935	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THECO_RS13945	COG1028	Short-chain dehydrogenase reductase Sdr
THECO_RS13955	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
THECO_RS13965	COG2814	Major facilitator Superfamily
THECO_RS13975	COG0596	Alpha beta hydrolase
THECO_RS13985	COG0431	NADPH-dependent FMN reductase
THECO_RS13990	COG2197	response regulator
THECO_RS13995	COG4585	Histidine kinase
THECO_RS13995	COG2203	Gaf domain
THECO_RS14000	COG2217	Heavy metal translocating P-type atpase
THECO_RS14020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
THECO_RS14025	COG4988	ABC transporter
THECO_RS14030	COG1294	oxidase, subunit
THECO_RS14035	COG1271	oxidase subunit
THECO_RS14145	COG0735	belongs to the Fur family
THECO_RS14150	COG1285	pathogenesis
THECO_RS14155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THECO_RS14160	COG0154	amidase activity
THECO_RS14165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THECO_RS14205	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
THECO_RS14225	COG2337	Toxic component of a toxin-antitoxin (TA) module
THECO_RS14230	COG0864	Transcriptional regulator
THECO_RS14235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THECO_RS14240	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
THECO_RS14260	COG0582	viral genome integration into host DNA
THECO_RS14315	COG4372	Transposase
THECO_RS14320	COG0745	RESPONSE REGULATOR receiver
THECO_RS14330	COG3507	Belongs to the glycosyl hydrolase 43 family
THECO_RS14340	COG1653	transport
THECO_RS14345	COG1472	Belongs to the glycosyl hydrolase 3 family
THECO_RS14350	COG0395	ABC-type sugar transport system, permease component
THECO_RS14355	COG4209	transmembrane transport
THECO_RS14360	COG3250	beta-galactosidase activity
THECO_RS14365	COG2723	6-phospho-beta-galactosidase activity
THECO_RS14390	COG1587	Uroporphyrinogen-III synthase
THECO_RS14395	COG0583	DNA-binding transcription factor activity
THECO_RS14400	COG0583	DNA-binding transcription factor activity
THECO_RS14405	COG2146	nitrite reductase [NAD(P)H] activity
THECO_RS14410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THECO_RS14415	COG1648	precorrin-2 dehydrogenase activity
THECO_RS14415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THECO_RS14420	COG2116	formate transmembrane transporter activity
THECO_RS14465	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THECO_RS14470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THECO_RS14475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THECO_RS14475	COG1321	iron dependent repressor
THECO_RS14480	COG1121	(ABC) transporter
THECO_RS14485	COG0803	Belongs to the bacterial solute-binding protein 9 family
THECO_RS14490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THECO_RS14510	COG2267	carboxylic ester hydrolase activity
THECO_RS14515	COG2081	HI0933 family
THECO_RS14525	COG1172	Belongs to the binding-protein-dependent transport system permease family
THECO_RS14530	COG1172	Belongs to the binding-protein-dependent transport system permease family
THECO_RS14535	COG1129	ABC transporter
THECO_RS14540	COG2207	Transcriptional regulator
THECO_RS14545	COG2972	Histidine kinase
THECO_RS14565	COG1131	(ABC) transporter
THECO_RS14585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THECO_RS14590	COG2801	Transposase and inactivated derivatives
THECO_RS14605	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THECO_RS14610	COG0456	acetyltransferase
THECO_RS14615	COG1214	PFAM Peptidase M22, glycoprotease
THECO_RS14620	COG0802	atpase or kinase
THECO_RS14625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THECO_RS14640	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
THECO_RS14650	COG1793	dna ligase
THECO_RS14660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
THECO_RS14680	COG0483	inositol monophosphate 1-phosphatase activity
THECO_RS14685	COG0730	response to heat
THECO_RS14700	COG1181	Belongs to the D-alanine--D-alanine ligase family
THECO_RS14710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
THECO_RS14725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
THECO_RS14730	COG0243	molybdopterin cofactor binding
THECO_RS14730	COG3383	formate dehydrogenase (NAD+) activity
THECO_RS14745	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THECO_RS14755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
THECO_RS14760	COG1285	pathogenesis
THECO_RS14765	COG0647	UMP catabolic process
THECO_RS14770	COG1234	tRNA 3'-trailer cleavage
THECO_RS14780	COG1175	transmembrane transport
THECO_RS14785	COG1653	transport
THECO_RS14795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
THECO_RS14800	COG0302	gtp cyclohydrolase
THECO_RS14815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THECO_RS14820	COG0328	RNA-DNA hybrid ribonuclease activity
THECO_RS14830	COG0456	acetyltransferase
THECO_RS14840	COG2378	regulation of single-species biofilm formation
THECO_RS14850	COG4470	Protein conserved in bacteria
THECO_RS14855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THECO_RS14860	COG0739	heme binding
THECO_RS14875	COG0673	inositol 2-dehydrogenase activity
THECO_RS14885	COG0673	inositol 2-dehydrogenase activity
THECO_RS14905	COG1253	flavin adenine dinucleotide binding
THECO_RS14910	COG1309	transcriptional regulator
THECO_RS14915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THECO_RS14920	COG0492	ferredoxin-NADP+ reductase activity
THECO_RS14925	COG2323	membrane
THECO_RS14930	COG2814	Major facilitator Superfamily
THECO_RS14940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THECO_RS14945	COG1079	Belongs to the binding-protein-dependent transport system permease family
THECO_RS14950	COG4603	Belongs to the binding-protein-dependent transport system permease family
THECO_RS14955	COG3845	ABC transporter
THECO_RS14975	COG0640	Transcriptional regulator
THECO_RS14985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THECO_RS14990	COG0569	domain protein
THECO_RS15000	COG0151	Belongs to the GarS family
THECO_RS15010	COG0138	bifunctional purine biosynthesis protein purh
THECO_RS15015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THECO_RS15020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THECO_RS15025	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THECO_RS15030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THECO_RS15035	COG0047	phosphoribosylformylglycinamidine synthase activity
THECO_RS15040	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THECO_RS15045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THECO_RS15050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THECO_RS15055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
THECO_RS15060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THECO_RS15085	COG2182	Extracellular solute-binding protein
THECO_RS15100	COG2972	Histidine kinase
THECO_RS15105	COG2207	Transcriptional regulator
THECO_RS15105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THECO_RS15120	COG3547	Transposase (IS116 IS110 IS902 family)
THECO_RS15175	COG3547	Transposase (IS116 IS110 IS902 family)
THECO_RS15180	COG3547	Transposase (IS116 IS110 IS902 family)
THECO_RS15185	COG3547	Transposase (IS116 IS110 IS902 family)
THECO_RS15195	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THECO_RS15200	COG1518	maintenance of DNA repeat elements
THECO_RS15235	COG2801	Transposase and inactivated derivatives
THECO_RS15240	COG2801	Transposase and inactivated derivatives
THECO_RS15250	COG3547	Transposase (IS116 IS110 IS902 family)
THECO_RS15260	COG2252	PERMEase
THECO_RS15270	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THECO_RS15275	COG0519	Catalyzes the synthesis of GMP from XMP
THECO_RS15275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THECO_RS15280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THECO_RS15305	COG4555	ABC transporter
THECO_RS15315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THECO_RS15320	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
THECO_RS15325	COG1131	(ABC) transporter
THECO_RS15335	COG1396	sequence-specific DNA binding
THECO_RS15340	COG0069	glutamate synthase activity
THECO_RS15340	COG0070	glutamate synthase
THECO_RS15340	COG0067	glutamate synthase
THECO_RS15350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THECO_RS15355	COG1396	sequence-specific DNA binding
THECO_RS15360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THECO_RS15365	COG0110	maltose O-acetyltransferase activity
THECO_RS15370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THECO_RS15415	COG1216	Glycosyl transferase, family 2
THECO_RS15450	COG1215	transferase activity, transferring glycosyl groups
THECO_RS15460	COG0438	transferase activity, transferring glycosyl groups
THECO_RS15465	COG0438	transferase activity, transferring glycosyl groups
THECO_RS15470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THECO_RS15475	COG1086	Polysaccharide biosynthesis protein
THECO_RS15480	COG1132	(ABC) transporter
THECO_RS15495	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
THECO_RS15520	COG0489	protein tyrosine kinase activity
THECO_RS15525	COG3944	biosynthesis protein
THECO_RS15530	COG1396	sequence-specific DNA binding
THECO_RS15535	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THECO_RS15540	COG0488	(ABC) transporter
THECO_RS15545	COG0673	inositol 2-dehydrogenase activity
THECO_RS15550	COG1413	lyase activity
THECO_RS15570	COG0105	UTP biosynthetic process
THECO_RS15585	COG3940	Belongs to the glycosyl hydrolase 43 family
THECO_RS15590	COG3507	Belongs to the glycosyl hydrolase 43 family
THECO_RS15595	COG0395	ABC-type sugar transport system, permease component
THECO_RS15600	COG1175	transmembrane transport
THECO_RS15625	COG0667	Aldo Keto reductase
THECO_RS15630	COG1063	alcohol dehydrogenase
THECO_RS15670	COG2207	Transcriptional regulator
THECO_RS15670	COG4753	response regulator
THECO_RS15675	COG2972	Histidine kinase
THECO_RS15685	COG0395	ABC-type sugar transport system, permease component
THECO_RS15690	COG4209	transmembrane transport
THECO_RS15715	COG0395	ABC-type sugar transport system, permease component
THECO_RS15725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THECO_RS15750	COG0647	UMP catabolic process
THECO_RS15755	COG1349	DNA-binding transcription factor activity
THECO_RS15765	COG0800	Aldolase
THECO_RS15775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THECO_RS15780	COG0432	Pfam Uncharacterised protein family UPF0047
THECO_RS15795	COG0194	GDP metabolic process
THECO_RS15800	COG0783	Belongs to the Dps family
THECO_RS15810	COG2197	response regulator
THECO_RS15820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THECO_RS15825	COG1882	Formate acetyltransferase
THECO_RS15830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
THECO_RS15835	COG0667	Aldo Keto reductase
THECO_RS15840	COG1733	regulation of RNA biosynthetic process
THECO_RS15845	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
THECO_RS15855	COG1696	Membrane protein involved in D-alanine export
THECO_RS15865	COG2207	Transcriptional regulator
THECO_RS15865	COG4753	response regulator
THECO_RS15870	COG2972	Histidine kinase
THECO_RS15880	COG0395	ABC-type sugar transport system, permease component
THECO_RS15885	COG4209	transmembrane transport
THECO_RS15890	COG0667	Aldo Keto reductase
THECO_RS15900	COG2770	Histidine kinase
THECO_RS15900	COG3437	response regulator, receiver
THECO_RS15910	COG1132	(ABC) transporter
THECO_RS15915	COG1132	(ABC) transporter
THECO_RS15920	COG0477	Major facilitator Superfamily
THECO_RS15935	COG1368	sulfuric ester hydrolase activity
THECO_RS15970	COG0534	Mate efflux family protein
THECO_RS16000	COG3547	Transposase (IS116 IS110 IS902 family)
THECO_RS16060	COG1131	(ABC) transporter
THECO_RS16065	COG2723	6-phospho-beta-galactosidase activity
THECO_RS16085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THECO_RS16095	COG1172	Belongs to the binding-protein-dependent transport system permease family
THECO_RS16100	COG1129	ABC transporter
THECO_RS16125	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THECO_RS16130	COG0395	ABC-type sugar transport system, permease component
THECO_RS16135	COG1175	transmembrane transport
THECO_RS16140	COG1653	transport
THECO_RS16145	COG1609	Transcriptional regulator
THECO_RS16150	COG1509	lysine 2,3-aminomutase activity
THECO_RS16155	COG2720	vancomycin resistance protein
THECO_RS16160	COG0686	Belongs to the AlaDH PNT family
THECO_RS16165	COG1609	Transcriptional regulator
THECO_RS16185	COG0395	ABC-type sugar transport system, permease component
THECO_RS16200	COG0395	ABC-type sugar transport system, permease component
THECO_RS16205	COG4209	transmembrane transport
THECO_RS16215	COG2207	Transcriptional regulator
THECO_RS16215	COG4753	response regulator
THECO_RS16220	COG3275	phosphorelay sensor kinase activity
THECO_RS16225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
THECO_RS16240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THECO_RS16250	COG2972	Histidine kinase
THECO_RS16255	COG2207	Transcriptional regulator
THECO_RS16255	COG4753	response regulator
THECO_RS16265	COG1175	transmembrane transport
THECO_RS16270	COG0395	ABC-type sugar transport system, permease component
THECO_RS16275	COG1116	anion transmembrane transporter activity
THECO_RS16280	COG4120	Belongs to the binding-protein-dependent transport system permease family
THECO_RS16310	COG3250	beta-galactosidase activity
THECO_RS16315	COG0395	ABC-type sugar transport system, permease component
THECO_RS16320	COG1175	transmembrane transport
THECO_RS16330	COG2207	Transcriptional regulator
THECO_RS16330	COG4753	response regulator
THECO_RS16335	COG2972	Histidine kinase
THECO_RS16350	COG1175	transmembrane transport
THECO_RS16405	COG1874	Beta-galactosidase
THECO_RS16415	COG0395	ABC-type sugar transport system, permease component
THECO_RS16420	COG4209	transmembrane transport
THECO_RS16430	COG4753	response regulator
THECO_RS16430	COG2207	Transcriptional regulator
THECO_RS16435	COG3275	phosphorelay sensor kinase activity
THECO_RS16445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
THECO_RS16450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THECO_RS16520	COG1078	dGTPase activity
THECO_RS16565	COG0732	type I restriction modification DNA specificity domain
THECO_RS16575	COG0745	RESPONSE REGULATOR receiver
THECO_RS16580	COG2205	protein histidine kinase activity
THECO_RS16585	COG1136	(ABC) transporter
THECO_RS16590	COG0577	efflux transmembrane transporter activity
THECO_RS16620	COG0697	spore germination
THECO_RS16645	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
THECO_RS16650	COG0745	RESPONSE REGULATOR receiver
THECO_RS16655	COG5002	protein histidine kinase activity
THECO_RS16705	COG1063	alcohol dehydrogenase
THECO_RS16730	COG1116	anion transmembrane transporter activity
THECO_RS16740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
THECO_RS16745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THECO_RS16750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THECO_RS16755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THECO_RS16770	COG0733	neurotransmitter:sodium symporter activity
THECO_RS16785	COG0733	neurotransmitter:sodium symporter activity
THECO_RS16825	COG0840	transmembrane signaling receptor activity
THECO_RS16835	COG5609	conserved protein (DUF2294)
THECO_RS16845	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
THECO_RS16850	COG1742	UPF0060 membrane protein
THECO_RS16860	COG0798	PFAM Bile acid sodium symporter
THECO_RS16865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THECO_RS16870	COG0475	glutathione-regulated potassium exporter activity
THECO_RS16880	COG0861	Integral membrane protein TerC family
THECO_RS16885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THECO_RS16890	COG3002	Belongs to the UPF0753 family
THECO_RS16895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THECO_RS16905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THECO_RS16910	COG0557	exoribonuclease II activity
THECO_RS16915	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THECO_RS16930	COG0148	phosphopyruvate hydratase activity
THECO_RS16935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THECO_RS16940	COG0149	triose-phosphate isomerase activity
THECO_RS16945	COG0126	phosphoglycerate kinase activity
THECO_RS16965	COG0740	serine-type endopeptidase activity
THECO_RS16970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THECO_RS16975	COG1481	regulation of sporulation
THECO_RS16980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
THECO_RS16985	COG1660	Displays ATPase and GTPase activities
THECO_RS16990	COG1940	carbohydrate kinase activity
THECO_RS16995	COG1309	transcriptional regulator
THECO_RS17010	COG0457	Tetratricopeptide repeat
THECO_RS17020	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THECO_RS17025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THECO_RS17025	COG0140	phosphoribosyl-ATP diphosphatase activity
THECO_RS17030	COG0107	imidazoleglycerol-phosphate synthase activity
THECO_RS17035	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THECO_RS17040	COG0131	Imidazoleglycerol-phosphate dehydratase
THECO_RS17045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THECO_RS17050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THECO_RS17055	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THECO_RS17065	COG0110	maltose O-acetyltransferase activity
THECO_RS17070	COG0546	phosphoglycolate phosphatase activity
THECO_RS17080	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
THECO_RS17085	COG3842	ATPase activity
THECO_RS17090	COG2508	Transcriptional regulator
THECO_RS17095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THECO_RS17160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THECO_RS17165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THECO_RS17170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THECO_RS17180	COG0254	rRNA binding
THECO_RS17190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THECO_RS17195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THECO_RS17200	COG0191	fructose-bisphosphate aldolase activity
THECO_RS17210	COG0504	CTP synthase activity
THECO_RS17220	COG3343	RNA polymerase activity
THECO_RS17225	COG1404	Belongs to the peptidase S8 family
THECO_RS17230	COG0018	arginyl-trna synthetase
THECO_RS17245	COG1473	amidohydrolase
THECO_RS17250	COG0456	acetyltransferase
THECO_RS17260	COG5522	Integral membrane protein (intg_mem_TP0381)
THECO_RS17275	COG2079	MmgE PrpD family protein
THECO_RS17280	COG1126	abc transporter atp-binding protein
THECO_RS17285	COG0765	amino acid transport
THECO_RS17290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THECO_RS17300	COG0010	Belongs to the arginase family
THECO_RS17305	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THECO_RS17310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THECO_RS17320	COG2409	Drug exporters of the RND superfamily
THECO_RS17340	COG0791	NLP P60 protein
THECO_RS17345	COG1201	RNA secondary structure unwinding
THECO_RS17355	COG1595	DNA-templated transcription, initiation
THECO_RS17370	COG0737	Belongs to the 5'-nucleotidase family
THECO_RS17380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THECO_RS17390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THECO_RS17395	COG0708	Exodeoxyribonuclease III
THECO_RS17405	COG2211	Major facilitator Superfamily
THECO_RS17410	COG3842	ATPase activity
THECO_RS17415	COG1176	ABC-type spermidine putrescine transport system, permease component I
THECO_RS17425	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THECO_RS17445	COG1175	transmembrane transport
THECO_RS17455	COG1653	transport
THECO_RS17495	COG2200	EAL domain
THECO_RS17505	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THECO_RS17510	COG1360	Flagellar Motor Protein
THECO_RS17515	COG4191	Histidine kinase
THECO_RS17540	COG4974	Belongs to the 'phage' integrase family
THECO_RS17600	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THECO_RS17640	COG1595	DNA-templated transcription, initiation
THECO_RS17650	COG2376	Dihydroxyacetone kinase
THECO_RS17655	COG1461	Dihydroxyacetone kinase
THECO_RS17660	COG1609	Transcriptional regulator
THECO_RS17665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THECO_RS17705	COG1136	(ABC) transporter
THECO_RS17705	COG0577	efflux transmembrane transporter activity
THECO_RS17710	COG2814	Major facilitator Superfamily
THECO_RS17725	COG0346	lactoylglutathione lyase activity
THECO_RS17755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THECO_RS17775	COG0516	GMP reductase activity
THECO_RS17775	COG0517	IMP dehydrogenase activity
THECO_RS17790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THECO_RS17795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THECO_RS17800	COG1396	sequence-specific DNA binding
THECO_RS17805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THECO_RS17810	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THECO_RS17815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THECO_RS17820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THECO_RS17825	COG0512	Glutamine amidotransferase of anthranilate synthase
THECO_RS17830	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THECO_RS17850	COG3344	reverse transcriptase
THECO_RS17860	COG0457	Tetratricopeptide repeat
THECO_RS17865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THECO_RS17870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THECO_RS17875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THECO_RS17880	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THECO_RS17890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
THECO_RS17895	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THECO_RS17900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THECO_RS17910	COG0037	tRNA processing
THECO_RS17915	COG0457	Tetratricopeptide repeat
THECO_RS17915	COG0515	serine threonine protein kinase
THECO_RS17920	COG2304	oxidoreductase activity
THECO_RS17925	COG2208	phosphoserine phosphatase activity
THECO_RS17940	COG0640	Transcriptional regulator
THECO_RS17945	COG1098	S1 RNA binding domain
THECO_RS17965	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THECO_RS17975	COG3956	TIGRFAM MazG family protein
THECO_RS17980	COG2002	toxin-antitoxin pair type II binding
THECO_RS17990	COG0310	cobalt ion transport
THECO_RS18050	COG1012	belongs to the aldehyde dehydrogenase family
THECO_RS18050	COG1454	alcohol dehydrogenase
THECO_RS18055	COG0583	DNA-binding transcription factor activity
THECO_RS18060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THECO_RS18065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THECO_RS18085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THECO_RS18090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THECO_RS18095	COG2088	sporulation resulting in formation of a cellular spore
THECO_RS18100	COG0251	oxidation-reduction process
THECO_RS18105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THECO_RS18110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THECO_RS18120	COG4466	Protein conserved in bacteria
THECO_RS18130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THECO_RS18135	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
THECO_RS18140	COG3583	domain protein
THECO_RS18140	COG3584	3D domain protein
THECO_RS18145	COG0084	hydrolase, TatD family'
THECO_RS18150	COG1078	dGTPase activity
THECO_RS18155	COG2002	toxin-antitoxin pair type II binding
THECO_RS18160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THECO_RS18165	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
THECO_RS18175	COG4467	Involved in initiation control of chromosome replication
THECO_RS18180	COG1774	PSP1 C-terminal conserved region
THECO_RS18185	COG0470	DNA polymerase III
THECO_RS18190	COG1728	Protein conserved in bacteria
THECO_RS18195	COG3870	Protein conserved in bacteria
THECO_RS18200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THECO_RS18205	COG1982	Orn Lys Arg decarboxylase major
THECO_RS18235	COG3437	response regulator, receiver
THECO_RS18240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THECO_RS18255	COG0187	DNA topoisomerase II activity
THECO_RS18265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THECO_RS18270	COG2501	S4 domain
THECO_RS18275	COG0592	DNA-directed DNA polymerase activity
THECO_RS18280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THECO_RS18285	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THECO_RS18290	COG0594	ribonuclease P activity
THECO_RS18295	COG0706	membrane insertase activity
THECO_RS18300	COG1847	R3H domain protein
THECO_RS18305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THECO_RS18310	COG0445	tRNA wobble uridine modification
THECO_RS18315	COG0357	Ribosomal RNA small subunit methyltransferase G
THECO_RS18320	COG1475	DNA binding
THECO_RS18325	COG1192	Involved in chromosome partitioning
THECO_RS18330	COG1475	DNA binding
THECO_RS18335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THECO_RS18355	COG0668	transmembrane transport
THECO_RS18360	COG4481	Protein conserved in bacteria
THECO_RS18380	COG0360	Binds together with S18 to 16S ribosomal RNA
THECO_RS18385	COG0629	single-stranded DNA binding
THECO_RS18390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THECO_RS18395	COG2207	Transcriptional regulator
THECO_RS18395	COG0662	Cupin 2, conserved barrel domain protein
THECO_RS18415	COG1316	TRANSCRIPTIONal
THECO_RS18435	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
THECO_RS18440	COG0359	binds to the 23S rRNA
THECO_RS18445	COG0305	Participates in initiation and elongation during chromosome replication
THECO_RS18450	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THECO_RS18480	COG0730	response to heat
THECO_RS18485	COG0425	Belongs to the sulfur carrier protein TusA family
THECO_RS18485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THECO_RS18490	COG0425	Belongs to the sulfur carrier protein TusA family
THECO_RS18490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THECO_RS18495	COG2210	Belongs to the sulfur carrier protein TusA family
THECO_RS18500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THECO_RS18500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THECO_RS18505	COG0425	Belongs to the sulfur carrier protein TusA family
THECO_RS18510	COG2210	Belongs to the sulfur carrier protein TusA family
THECO_RS18515	COG1937	Protein conserved in bacteria
THECO_RS18520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THECO_RS18545	COG2826	transposase and inactivated derivatives, IS30 family
THECO_RS18580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THECO_RS18610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THECO_RS18630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THECO_RS18635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THECO_RS18645	COG5492	domain, Protein
THECO_RS18645	COG4932	domain protein
THECO_RS18670	COG1609	Transcriptional regulator
THECO_RS18680	COG2385	sporulation resulting in formation of a cellular spore
THECO_RS18690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THECO_RS18705	COG1007	ATP synthesis coupled electron transport
THECO_RS18710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THECO_RS18715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THECO_RS18720	COG0713	ATP synthesis coupled electron transport
THECO_RS18725	COG0839	Belongs to the complex I subunit 6 family
THECO_RS18735	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THECO_RS18740	COG0649	NAD binding
THECO_RS18750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THECO_RS18755	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THECO_RS18760	COG1132	(ABC) transporter
THECO_RS18765	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THECO_RS18770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THECO_RS18775	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THECO_RS18780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THECO_RS18785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THECO_RS18790	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THECO_RS18795	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THECO_RS18800	COG0356	it plays a direct role in the translocation of protons across the membrane
THECO_RS18815	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THECO_RS18820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
THECO_RS18855	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THECO_RS18865	COG1459	type II secretion system
THECO_RS18870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THECO_RS18875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THECO_RS18885	COG0698	ribose 5-phosphate isomerase
THECO_RS18895	COG1971	Probably functions as a manganese efflux pump
THECO_RS18900	COG0009	L-threonylcarbamoyladenylate synthase
THECO_RS18915	COG2890	protein-(glutamine-N5) methyltransferase activity
THECO_RS18920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THECO_RS18925	COG0012	GTP binding
THECO_RS18930	COG3118	belongs to the thioredoxin family
THECO_RS18940	COG0656	L-ascorbic acid biosynthetic process
THECO_RS18945	COG1801	Protein of unknown function DUF72
THECO_RS18965	COG2076	Multidrug Resistance protein
THECO_RS18980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THECO_RS18985	COG1215	transferase activity, transferring glycosyl groups
THECO_RS18990	COG1091	dTDP-4-dehydrorhamnose reductase activity
THECO_RS19005	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
THECO_RS19040	COG1216	Glycosyl transferase, family 2
THECO_RS19040	COG0438	transferase activity, transferring glycosyl groups
THECO_RS19050	COG1682	transport, permease protein
THECO_RS19070	COG3693	PFAM glycoside hydrolase, family 10
THECO_RS19075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THECO_RS19080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THECO_RS19090	COG0386	Belongs to the glutathione peroxidase family
THECO_RS19110	COG2814	Major facilitator Superfamily
THECO_RS19115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THECO_RS19120	COG1621	beta-fructofuranosidase activity
THECO_RS19125	COG2186	Transcriptional regulator
THECO_RS19130	COG3634	alkyl hydroperoxide reductase activity
THECO_RS19135	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
THECO_RS19140	COG1368	sulfuric ester hydrolase activity
THECO_RS19145	COG0667	Aldo Keto reductase
THECO_RS19170	COG2409	Drug exporters of the RND superfamily
THECO_RS19170	COG1033	growth of symbiont in host cell
THECO_RS19180	COG5002	protein histidine kinase activity
THECO_RS19190	COG1132	(ABC) transporter
THECO_RS19195	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THECO_RS19210	COG0395	ABC-type sugar transport system, permease component
THECO_RS19215	COG1175	transmembrane transport
THECO_RS19225	COG1132	(ABC) transporter
THECO_RS19230	COG1132	(ABC) transporter
THECO_RS19250	COG1028	Short-chain dehydrogenase reductase Sdr
THECO_RS19275	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THECO_RS19285	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
THECO_RS19290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THECO_RS19480	COG3693	PFAM glycoside hydrolase, family 10
THECO_RS19485	COG3693	PFAM glycoside hydrolase, family 10
THECO_RS19750	COG1129	ABC transporter
THECO_RS19925	COG1178	ABC-type Fe3 transport system permease component
THECO_RS20035	COG0733	neurotransmitter:sodium symporter activity
THECO_RS20285	COG2911	Protein conserved in bacteria
THECO_RS20285	COG3266	domain, Protein
THECO_RS20285	COG1361	Conserved repeat domain
THECO_RS20290	COG1040	competence protein
THECO_RS20310	COG0653	protein targeting
THECO_RS20325	COG4585	Histidine kinase
THECO_RS20365	COG3266	domain, Protein
THECO_RS20365	COG1361	Conserved repeat domain
THECO_RS20365	COG2911	Protein conserved in bacteria
THECO_RS20380	COG1309	transcriptional regulator
THECO_RS20390	COG0739	heme binding
THECO_RS20405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THECO_RS20425	COG5002	protein histidine kinase activity
THECO_RS20475	COG1705	Flagellar rod assembly protein muramidase FlgJ
THECO_RS20490	COG4717	serine-type aminopeptidase activity
THECO_RS20535	COG0515	serine threonine protein kinase
THECO_RS20535	COG2815	serine threonine protein kinase
THECO_RS20575	COG1555	photosystem II stabilization
THECO_RS20605	COG0189	ligase activity
THECO_RS20615	COG0789	Transcriptional regulator
THECO_RS20625	COG1361	Conserved repeat domain
THECO_RS20630	COG1361	Conserved repeat domain
THECO_RS20630	COG2911	Protein conserved in bacteria
THECO_RS20630	COG3266	domain, Protein
THECO_RS20635	COG3328	transposase activity
THECO_RS20655	COG1523	belongs to the glycosyl hydrolase 13 family
THECO_RS20665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THECO_RS20670	COG0741	lytic transglycosylase activity
THECO_RS20670	COG1196	nuclear chromosome segregation
THECO_RS20670	COG0739	heme binding
THECO_RS20680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THECO_RS20690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THECO_RS20695	COG1842	Phage shock protein A
THECO_RS20705	COG5002	protein histidine kinase activity
THECO_RS20715	COG1501	Belongs to the glycosyl hydrolase 31 family
THECO_RS20730	COG3300	MHYT domain
THECO_RS20730	COG5001	Diguanylate cyclase
THECO_RS20745	COG0726	polysaccharide deacetylase
THECO_RS20750	COG0358	DNA primase activity
THECO_RS20755	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient